ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of vascular permeability (GO:0043117)	8.63138338
2	cGMP-mediated signaling (GO:0019934)	6.57504570
3	ATP synthesis coupled proton transport (GO:0015986)	5.98505003
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.98505003
5	sequestering of actin monomers (GO:0042989)	5.98128530
6	negative regulation of catenin import into nucleus (GO:0035414)	5.97656174
7	negative regulation of vascular permeability (GO:0043116)	5.73201702
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.71520238
9	cAMP catabolic process (GO:0006198)	5.48369320
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.42302835
11	DNA strand renaturation (GO:0000733)	4.98391566
12	proteasome assembly (GO:0043248)	4.80890494
13	cyclic nucleotide catabolic process (GO:0009214)	4.80570866
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.30323195
15	NADH dehydrogenase complex assembly (GO:0010257)	4.30323195
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.30323195
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.19251161
18	cellular response to exogenous dsRNA (GO:0071360)	4.18988071
19	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	4.00097737
20	peptidyl-lysine dimethylation (GO:0018027)	3.99140645
21	viral transcription (GO:0019083)	3.81831015
22	GTP biosynthetic process (GO:0006183)	3.80982617
23	protein neddylation (GO:0045116)	3.79091548
24	electron transport chain (GO:0022900)	3.78026788
25	respiratory electron transport chain (GO:0022904)	3.76566305
26	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.75783969
27	ATP biosynthetic process (GO:0006754)	3.74142290
28	cAMP-mediated signaling (GO:0019933)	3.67696756
29	protein complex biogenesis (GO:0070271)	3.65637114
30	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.63173933
31	retina layer formation (GO:0010842)	3.61305678
32	translational termination (GO:0006415)	3.54711263
33	platelet dense granule organization (GO:0060155)	3.43837745
34	otic vesicle formation (GO:0030916)	3.35178750
35	translational elongation (GO:0006414)	3.32399031
36	muscle filament sliding (GO:0030049)	3.29858561
37	actin-myosin filament sliding (GO:0033275)	3.29858561
38	calcium-mediated signaling using intracellular calcium source (GO:0035584)	3.20406699
39	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.19201886
40	UTP metabolic process (GO:0046051)	3.15511560
41	UTP biosynthetic process (GO:0006228)	3.14833680
42	cAMP metabolic process (GO:0046058)	3.10941967
43	antigen processing and presentation via MHC class Ib (GO:0002475)	3.10917782
44	ribosomal small subunit biogenesis (GO:0042274)	3.07327374
45	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.04266909
46	mitochondrial respiratory chain complex assembly (GO:0033108)	3.03835320
47	positive regulation of protein export from nucleus (GO:0046827)	3.01819559
48	cell proliferation in forebrain (GO:0021846)	3.00160447
49	spinal cord association neuron differentiation (GO:0021527)	2.97609727
50	neuron fate specification (GO:0048665)	2.95162463
51	negative regulation of systemic arterial blood pressure (GO:0003085)	2.91682748
52	cardiovascular system development (GO:0072358)	2.90507255
53	protein targeting to mitochondrion (GO:0006626)	2.90408507
54	pre-miRNA processing (GO:0031054)	2.88075578
55	response to gravity (GO:0009629)	2.87399531
56	establishment of protein localization to mitochondrion (GO:0072655)	2.86552394
57	nucleoside triphosphate biosynthetic process (GO:0009142)	2.83701708
58	cellular protein complex disassembly (GO:0043624)	2.82710636
59	protein localization to mitochondrion (GO:0070585)	2.82322699
60	guanosine-containing compound biosynthetic process (GO:1901070)	2.78167975
61	pattern specification involved in kidney development (GO:0061004)	2.75611763
62	proximal/distal pattern formation (GO:0009954)	2.72248464
63	nuclear envelope reassembly (GO:0031468)	2.71829095
64	mitotic nuclear envelope reassembly (GO:0007084)	2.71829095
65	positive regulation of osteoblast proliferation (GO:0033690)	2.71512198
66	cotranslational protein targeting to membrane (GO:0006613)	2.69790394
67	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.69626707
68	protein targeting to ER (GO:0045047)	2.69531217
69	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.67464424
70	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.65412274
71	actin-mediated cell contraction (GO:0070252)	2.64919492
72	regulation of vascular permeability (GO:0043114)	2.63834130
73	regulation of male gonad development (GO:2000018)	2.62818659
74	regulation of phospholipid biosynthetic process (GO:0071071)	2.61956270
75	ganglion development (GO:0061548)	2.61622741
76	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.60743271
77	viral life cycle (GO:0019058)	2.60030091
78	nucleoside diphosphate phosphorylation (GO:0006165)	2.57535999
79	cyclic-nucleotide-mediated signaling (GO:0019935)	2.57396306
80	regulation of cell communication by electrical coupling (GO:0010649)	2.56744488
81	regulation of catenin import into nucleus (GO:0035412)	2.56347812
82	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.55546469
83	termination of RNA polymerase III transcription (GO:0006386)	2.55546469
84	rRNA methylation (GO:0031167)	2.54474892
85	cGMP metabolic process (GO:0046068)	2.53044313
86	adrenergic receptor signaling pathway (GO:0071875)	2.52882819
87	regulation of endothelial cell differentiation (GO:0045601)	2.51508299
88	protein localization to endoplasmic reticulum (GO:0070972)	2.47024743
89	somite development (GO:0061053)	2.46690297
90	limb bud formation (GO:0060174)	2.45552371
91	hydrogen ion transmembrane transport (GO:1902600)	2.44339162
92	CTP biosynthetic process (GO:0006241)	2.43344244
93	CTP metabolic process (GO:0046036)	2.43344244
94	artery smooth muscle contraction (GO:0014824)	2.43120726
95	protein complex disassembly (GO:0043241)	2.42301518
96	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	2.40891498
97	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.39168288
98	detection of calcium ion (GO:0005513)	2.37736137
99	sulfation (GO:0051923)	2.37113571
100	retinal ganglion cell axon guidance (GO:0031290)	2.36143970

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.93750830
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.51286002
3	VDR_22108803_ChIP-Seq_LS180_Human	3.43223755
4	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	3.31225047
5	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	3.23911696
6	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	3.18050216
7	EED_16625203_ChIP-ChIP_MESCs_Mouse	3.15445256
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.11758703
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.93422703
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.79245847
11	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.76484446
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.71975222
13	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.64755534
14	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.60037782
15	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.57607979
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.51813352
17	TP53_20018659_ChIP-ChIP_R1E_Mouse	2.47182725
18	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.46737005
19	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.45522257
20	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.45522257
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.38651229
22	RNF2_27304074_Chip-Seq_NSC_Mouse	2.28398440
23	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.27783684
24	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.17643239
25	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.15767584
26	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.13468199
27	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.02600992
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.69509693
29	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.68077744
30	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.67661101
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.66039314
32	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.61998501
33	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.61749792
34	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.53113662
35	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.50862624
36	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.49004430
37	FUS_26573619_Chip-Seq_HEK293_Human	1.46946766
38	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.45910778
39	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.45399270
40	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.42574353
41	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.41219326
42	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.36979577
43	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.35551808
44	GBX2_23144817_ChIP-Seq_PC3_Human	1.34188591
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32774176
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32774176
47	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.32525957
48	EWS_26573619_Chip-Seq_HEK293_Human	1.32266122
49	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.32157846
50	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.21156234
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.19225195
52	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.17394070
53	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.15035456
54	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.14779195
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14462006
56	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.12542200
57	TAF15_26573619_Chip-Seq_HEK293_Human	1.11435184
58	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.08961193
59	P300_19829295_ChIP-Seq_ESCs_Human	1.06689079
60	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.05218138
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03615801
62	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.03614525
63	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.03164107
64	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.01548636
65	AR_25329375_ChIP-Seq_VCAP_Human	1.00794050
66	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.00500326
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97833462
68	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.97812228
69	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.95117993
70	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.94804278
71	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.94604809
72	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.92735057
73	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.91179743
74	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.90602876
75	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.90212084
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.89231537
77	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.88660153
78	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.87929532
79	SA1_22415368_ChIP-Seq_MEFs_Mouse	0.87459169
80	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.86384545
81	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.85665149
82	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85568717
83	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.85254119
84	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.85175484
85	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.84828743
86	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.84354109
87	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.83183641
88	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.82500450
89	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.82298697
90	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.82109543
91	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.78530474
92	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.78126012
93	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.77762345
94	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.77435521
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.77249327
96	AR_21572438_ChIP-Seq_LNCaP_Human	0.76557983
97	HTT_18923047_ChIP-ChIP_STHdh_Human	0.76549839
98	SOX9_26525672_Chip-Seq_HEART_Mouse	0.74739113
99	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.74458118
100	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.74334882

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005084_abnormal_gallbladder_morpholo	4.31098481
2	MP0002877_abnormal_melanocyte_morpholog	3.81887898
3	MP0009379_abnormal_foot_pigmentation	3.64446529
4	MP0000566_synostosis	3.12692785
5	MP0002837_dystrophic_cardiac_calcinosis	2.71008225
6	MP0010030_abnormal_orbit_morphology	2.62488955
7	MP0003878_abnormal_ear_physiology	2.51967259
8	MP0005377_hearing/vestibular/ear_phenot	2.51967259
9	MP0002102_abnormal_ear_morphology	2.42501626
10	MP0004215_abnormal_myocardial_fiber	2.32295837
11	MP0004510_myositis	2.25745739
12	MP0009250_abnormal_appendicular_skeleto	2.18946666
13	MP0003879_abnormal_hair_cell	2.09888396
14	MP0004142_abnormal_muscle_tone	1.99126139
15	MP0004133_heterotaxia	1.98920753
16	MP0000631_abnormal_neuroendocrine_gland	1.98367567
17	MP0006072_abnormal_retinal_apoptosis	1.89754010
18	MP0003136_yellow_coat_color	1.83447005
19	MP0002928_abnormal_bile_duct	1.76633561
20	MP0003646_muscle_fatigue	1.76452395
21	MP0000049_abnormal_middle_ear	1.73351089
22	MP0000462_abnormal_digestive_system	1.66199244
23	MP0005670_abnormal_white_adipose	1.64062654
24	MP0002938_white_spotting	1.62426297
25	MP0000750_abnormal_muscle_regeneration	1.59862097
26	MP0001879_abnormal_lymphatic_vessel	1.56843277
27	MP0003638_abnormal_response/metabolism_	1.50111908
28	MP0003137_abnormal_impulse_conducting	1.49786868
29	MP0003315_abnormal_perineum_morphology	1.44258684
30	MP0005171_absent_coat_pigmentation	1.38683525
31	MP0002822_catalepsy	1.38126919
32	MP0000749_muscle_degeneration	1.34189719
33	MP0003937_abnormal_limbs/digits/tail_de	1.32490579
34	MP0002736_abnormal_nociception_after	1.30213619
35	MP0001485_abnormal_pinna_reflex	1.29613688
36	MP0008995_early_reproductive_senescence	1.28438562
37	MP0004145_abnormal_muscle_electrophysio	1.28195377
38	MP0004134_abnormal_chest_morphology	1.23750427
39	MP0004085_abnormal_heartbeat	1.23019205
40	MP0004742_abnormal_vestibular_system	1.20673266
41	MP0001188_hyperpigmentation	1.20661521
42	MP0001919_abnormal_reproductive_system	1.19437897
43	MP0002089_abnormal_postnatal_growth/wei	1.18456336
44	MP0004484_altered_response_of	1.15795616
45	MP0002735_abnormal_chemical_nociception	1.14397012
46	MP0003252_abnormal_bile_duct	1.13416086
47	MP0003283_abnormal_digestive_organ	1.12862546
48	MP0005620_abnormal_muscle_contractility	1.12074668
49	MP0000372_irregular_coat_pigmentation	1.11905959
50	MP0006138_congestive_heart_failure	1.10531589
51	MP0000751_myopathy	1.09367951
52	MP0006292_abnormal_olfactory_placode	1.09108730
53	MP0005646_abnormal_pituitary_gland	1.08245543
54	MP0004885_abnormal_endolymph	1.07637486
55	MP0008872_abnormal_physiological_respon	1.07628539
56	MP0002095_abnormal_skin_pigmentation	1.07500217
57	MP0005408_hypopigmentation	1.06689723
58	MP0001440_abnormal_grooming_behavior	1.03379029
59	MP0005220_abnormal_exocrine_pancreas	1.02460087
60	MP0005253_abnormal_eye_physiology	1.02081799
61	MP0004130_abnormal_muscle_cell	1.01293384
62	MP0005551_abnormal_eye_electrophysiolog	1.00941687
63	MP0005360_urolithiasis	0.99170720
64	MP0002972_abnormal_cardiac_muscle	0.98485143
65	MP0003119_abnormal_digestive_system	0.97999708
66	MP0002557_abnormal_social/conspecific_i	0.96736163
67	MP0000762_abnormal_tongue_morphology	0.96686636
68	MP0003942_abnormal_urinary_system	0.94318550
69	MP0002272_abnormal_nervous_system	0.92831397
70	MP0003011_delayed_dark_adaptation	0.92233454
71	MP0003938_abnormal_ear_development	0.92066936
72	MP0008775_abnormal_heart_ventricle	0.91738192
73	MP0008569_lethality_at_weaning	0.91641164
74	MP0000026_abnormal_inner_ear	0.90898268
75	MP0002572_abnormal_emotion/affect_behav	0.90534602
76	MP0005464_abnormal_platelet_physiology	0.90198866
77	MP0003123_paternal_imprinting	0.89419598
78	MP0000747_muscle_weakness	0.84711915
79	MP0008961_abnormal_basal_metabolism	0.84433209
80	MP0000537_abnormal_urethra_morphology	0.84391276
81	MP0000230_abnormal_systemic_arterial	0.84044357
82	MP0004084_abnormal_cardiac_muscle	0.83991870
83	MP0002734_abnormal_mechanical_nocicepti	0.83409177
84	MP0009745_abnormal_behavioral_response	0.82973709
85	MP0001544_abnormal_cardiovascular_syste	0.82781798
86	MP0005385_cardiovascular_system_phenoty	0.82781798
87	MP0000778_abnormal_nervous_system	0.81835393
88	MP0004087_abnormal_muscle_fiber	0.81044836
89	MP0002295_abnormal_pulmonary_circulatio	0.80594244
90	MP0002332_abnormal_exercise_endurance	0.79254424
91	MP0000759_abnormal_skeletal_muscle	0.78440233
92	MP0005165_increased_susceptibility_to	0.78432597
93	MP0002106_abnormal_muscle_physiology	0.78042071
94	MP0005187_abnormal_penis_morphology	0.76890821
95	MP0002638_abnormal_pupillary_reflex	0.75923323
96	MP0002127_abnormal_cardiovascular_syste	0.73129721
97	MP0002067_abnormal_sensory_capabilities	0.71561040
98	MP0002090_abnormal_vision	0.71412418
99	MP0005381_digestive/alimentary_phenotyp	0.70573369
100	MP0001486_abnormal_startle_reflex	0.69239319

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	4.00731647
2	Hyperalaninemia (HP:0003348)	4.00731647
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.00731647
4	Mitochondrial inheritance (HP:0001427)	3.88879337
5	Increased hepatocellular lipid droplets (HP:0006565)	3.82311178
6	Chronic otitis media (HP:0000389)	3.80558347
7	Renal Fanconi syndrome (HP:0001994)	3.79437103
8	Acute necrotizing encephalopathy (HP:0006965)	3.78452833
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.57782690
10	Large eyes (HP:0001090)	3.38380827
11	Lipid accumulation in hepatocytes (HP:0006561)	3.25774360
12	Progressive macrocephaly (HP:0004481)	3.23454733
13	Increased intramyocellular lipid droplets (HP:0012240)	3.23273412
14	Hepatocellular necrosis (HP:0001404)	3.12356608
15	Reduced subcutaneous adipose tissue (HP:0003758)	3.05503936
16	Increased CSF lactate (HP:0002490)	3.00251331
17	Exertional dyspnea (HP:0002875)	2.97752494
18	Respiratory difficulties (HP:0002880)	2.94727129
19	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.92346627
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.92346627
21	Alveolar cell carcinoma (HP:0006519)	2.90971208
22	Muscle fiber atrophy (HP:0100295)	2.86076315
23	Acute encephalopathy (HP:0006846)	2.84818368
24	Pendular nystagmus (HP:0012043)	2.84680639
25	Hepatic necrosis (HP:0002605)	2.84156523
26	Abnormality of the Achilles tendon (HP:0005109)	2.83753827
27	Congenital, generalized hypertrichosis (HP:0004540)	2.80249130
28	Achilles tendon contracture (HP:0001771)	2.79153896
29	Abnormal atrioventricular conduction (HP:0005150)	2.73477474
30	Primary atrial arrhythmia (HP:0001692)	2.72401186
31	Congenital stationary night blindness (HP:0007642)	2.71873465
32	Increased serum pyruvate (HP:0003542)	2.69408215
33	Heart block (HP:0012722)	2.68682549
34	Supraventricular tachycardia (HP:0004755)	2.67528575
35	Maternal diabetes (HP:0009800)	2.66014142
36	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.64576846
37	Supraventricular arrhythmia (HP:0005115)	2.62042404
38	Esophageal atresia (HP:0002032)	2.60735847
39	Neoplasm of the tracheobronchial system (HP:0100552)	2.60193908
40	Agitation (HP:0000713)	2.57598970
41	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.54106003
42	Increased muscle lipid content (HP:0009058)	2.48214923
43	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45858095
44	Oral leukoplakia (HP:0002745)	2.45305127
45	Abnormality of renal resorption (HP:0011038)	2.39949569
46	Elevated erythrocyte sedimentation rate (HP:0003565)	2.39401446
47	Chronic sinusitis (HP:0011109)	2.33258616
48	Lipoatrophy (HP:0100578)	2.30114877
49	Bundle branch block (HP:0011710)	2.25865631
50	Abnormality of glycolysis (HP:0004366)	2.21406222
51	Anomalous pulmonary venous return (HP:0010772)	2.19516912
52	Atrioventricular block (HP:0001678)	2.18355175
53	Nasal polyposis (HP:0100582)	2.17366503
54	Abnormal number of erythroid precursors (HP:0012131)	2.16930465
55	Flat capital femoral epiphysis (HP:0003370)	2.15639448
56	Neoplasm of the heart (HP:0100544)	2.14461380
57	Cerebral edema (HP:0002181)	2.13678473
58	Short femoral neck (HP:0100864)	2.12601831
59	Atrial fibrillation (HP:0005110)	2.11235983
60	Palpebral edema (HP:0100540)	2.10567457
61	Hemiplegia (HP:0002301)	2.10510272
62	Aplasia/Hypoplasia of the patella (HP:0006498)	2.07855577
63	Abnormality of the calf musculature (HP:0001430)	2.07838630
64	Sclerocornea (HP:0000647)	2.07165266
65	Hyperphosphaturia (HP:0003109)	2.05327015
66	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.04853464
67	Leukodystrophy (HP:0002415)	2.03717395
68	Decreased central vision (HP:0007663)	2.03434713
69	Abnormality of urine glucose concentration (HP:0011016)	2.03329977
70	Glycosuria (HP:0003076)	2.03329977
71	Axonal loss (HP:0003447)	2.02273591
72	True hermaphroditism (HP:0010459)	2.02161743
73	Aplasia involving bones of the extremities (HP:0009825)	2.01351357
74	Aplasia involving bones of the upper limbs (HP:0009823)	2.01351357
75	Aplasia of the phalanges of the hand (HP:0009802)	2.01351357
76	Elbow flexion contracture (HP:0002987)	1.99611264
77	Abnormality of cells of the erythroid lineage (HP:0012130)	1.96320716
78	Calf muscle hypertrophy (HP:0008981)	1.94765628
79	Short hallux (HP:0010109)	1.94632439
80	Abnormality of the pulmonary veins (HP:0011718)	1.94079715
81	Abnormality of the middle phalanges of the toes (HP:0010183)	1.93564509
82	Congenital sensorineural hearing impairment (HP:0008527)	1.92881583
83	Patchy hypopigmentation of hair (HP:0011365)	1.91581589
84	Lactic acidosis (HP:0003128)	1.90856770
85	Exercise intolerance (HP:0003546)	1.89256745
86	Ventricular tachycardia (HP:0004756)	1.89245599
87	Septo-optic dysplasia (HP:0100842)	1.88330855
88	Abdominal situs inversus (HP:0003363)	1.86768537
89	Abnormality of abdominal situs (HP:0011620)	1.86768537
90	Infantile muscular hypotonia (HP:0008947)	1.86403550
91	Nasolacrimal duct obstruction (HP:0000579)	1.84147671
92	Sudden death (HP:0001699)	1.82518085
93	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.82034383
94	Muscle hypertrophy of the lower extremities (HP:0008968)	1.81747646
95	Lissencephaly (HP:0001339)	1.80067412
96	Optic disc pallor (HP:0000543)	1.79360119
97	Skin nodule (HP:0200036)	1.78199673
98	Nausea (HP:0002018)	1.77538870
99	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.77270278
100	Midline defect of the nose (HP:0004122)	1.75751570

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.01601894
2	TLK1	3.98921969
3	GRK7	2.87052558
4	MAP2K7	2.73464903
5	MYLK	2.69490687
6	MAP3K12	2.25669668
7	TAF1	2.17027104
8	MOS	2.16111065
9	MARK1	2.04493783
10	LIMK1	2.03764339
11	ZAK	1.90839161
12	EPHB2	1.90576333
13	GRK1	1.85598428
14	TESK1	1.83323732
15	PHKG2	1.80866975
16	PHKG1	1.80866975
17	MAP3K4	1.78547561
18	BCKDK	1.78374778
19	PRKCI	1.77767288
20	VRK2	1.77750591
21	BLK	1.74369427
22	AURKA	1.72668710
23	MAP2K4	1.67603857
24	VRK1	1.59070484
25	DMPK	1.58993775
26	GRK5	1.56753209
27	MAP3K11	1.47144223
28	STK24	1.45268259
29	MAP3K5	1.39591920
30	PDK2	1.38712421
31	ILK	1.38400420
32	TGFBR2	1.31658723
33	CASK	1.30204015
34	TNIK	1.29749856
35	CAMK1D	1.27481709
36	ADRBK2	1.25761843
37	WNK3	1.20523244
38	MAPK13	1.16344855
39	NME1	1.15843622
40	DAPK3	1.13769702
41	PNCK	1.13143466
42	MAPKAPK3	1.11210366
43	STK10	1.08296469
44	MAPKAPK5	1.03956148
45	BUB1	1.03665956
46	CAMK1G	1.01457831
47	ADRBK1	0.98271223
48	NTRK2	0.96538594
49	MAPK15	0.90320213
50	STK16	0.86799670
51	DYRK2	0.85138728
52	PTK2	0.84475324
53	CCNB1	0.82794431
54	STK38L	0.81858003
55	CAMKK2	0.80932109
56	PAK3	0.80850732
57	BRSK1	0.78470921
58	PKN1	0.77704991
59	PIM2	0.75033683
60	PINK1	0.69362448
61	MINK1	0.66948244
62	LMTK2	0.66160097
63	OBSCN	0.63658570
64	CAMK2A	0.62774121
65	RPS6KA5	0.61066627
66	MAPK12	0.60033624
67	PRKACA	0.58148231
68	CHEK2	0.57069216
69	NUAK1	0.56920061
70	PRKCG	0.56697963
71	ABL2	0.55997343
72	INSRR	0.55913284
73	CDK8	0.54877935
74	STK4	0.49553677
75	DYRK3	0.49259751
76	CAMK4	0.48540058
77	MUSK	0.44636327
78	CAMK2G	0.44583502
79	EIF2AK2	0.43671221
80	CAMK2D	0.42544442
81	WEE1	0.42040276
82	CSNK1G2	0.41832288
83	PIM1	0.41372395
84	PIK3CG	0.41364457
85	CSNK2A1	0.40804792
86	CDK9	0.39803413
87	ROCK1	0.38835596
88	BRSK2	0.38288548
89	ERBB4	0.38237062
90	TTN	0.37572221
91	TIE1	0.36727595
92	PRKACG	0.36374199
93	LRRK2	0.35883776
94	PRKG1	0.35243686
95	TESK2	0.35083885
96	CAMK1	0.35024999
97	AURKB	0.35019816
98	MAPKAPK2	0.34906909
99	PAK1	0.33511744
100	CSNK2A2	0.31936524

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.35951514
2	Ribosome_Homo sapiens_hsa03010	4.06470474
3	Parkinsons disease_Homo sapiens_hsa05012	3.83320622
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.56677024
5	Sulfur relay system_Homo sapiens_hsa04122	3.05327204
6	Sulfur metabolism_Homo sapiens_hsa00920	2.92643104
7	Huntingtons disease_Homo sapiens_hsa05016	2.90098145
8	Alzheimers disease_Homo sapiens_hsa05010	2.81246149
9	Proteasome_Homo sapiens_hsa03050	2.56585039
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.45726949
11	Morphine addiction_Homo sapiens_hsa05032	2.21487307
12	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.10140649
13	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.94833540
14	Folate biosynthesis_Homo sapiens_hsa00790	1.89131062
15	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.79475013
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70262003
17	RNA polymerase_Homo sapiens_hsa03020	1.68536622
18	Basal cell carcinoma_Homo sapiens_hsa05217	1.62133439
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.60123664
20	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.54218017
21	Olfactory transduction_Homo sapiens_hsa04740	1.33055514
22	Salivary secretion_Homo sapiens_hsa04970	1.31620039
23	Nicotine addiction_Homo sapiens_hsa05033	1.31045290
24	Purine metabolism_Homo sapiens_hsa00230	1.21703163
25	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.16992706
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.16980219
27	Phototransduction_Homo sapiens_hsa04744	1.13061149
28	Glutathione metabolism_Homo sapiens_hsa00480	1.09178220
29	Basal transcription factors_Homo sapiens_hsa03022	1.06563366
30	Nitrogen metabolism_Homo sapiens_hsa00910	0.99637495
31	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.98839494
32	Arginine and proline metabolism_Homo sapiens_hsa00330	0.97303012
33	cAMP signaling pathway_Homo sapiens_hsa04024	0.96152497
34	GABAergic synapse_Homo sapiens_hsa04727	0.95196509
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88760084
36	Renin secretion_Homo sapiens_hsa04924	0.88360117
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.86939507
38	Alcoholism_Homo sapiens_hsa05034	0.83893946
39	Insulin secretion_Homo sapiens_hsa04911	0.83650304
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.83629439
41	Taste transduction_Homo sapiens_hsa04742	0.82770329
42	Serotonergic synapse_Homo sapiens_hsa04726	0.82470374
43	Phenylalanine metabolism_Homo sapiens_hsa00360	0.82169133
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80710751
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76956196
46	Tyrosine metabolism_Homo sapiens_hsa00350	0.73123122
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72813258
48	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.72726438
49	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.72705419
50	Regulation of autophagy_Homo sapiens_hsa04140	0.71324183
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.69291558
52	Histidine metabolism_Homo sapiens_hsa00340	0.66882877
53	Galactose metabolism_Homo sapiens_hsa00052	0.66555305
54	Circadian entrainment_Homo sapiens_hsa04713	0.66102076
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66053300
56	Gap junction_Homo sapiens_hsa04540	0.64812220
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64051643
58	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.63508274
59	Mineral absorption_Homo sapiens_hsa04978	0.63006945
60	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.62430011
61	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61678454
62	Cocaine addiction_Homo sapiens_hsa05030	0.58853240
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57417589
64	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.52900957
65	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.51420815
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48524179
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48308584
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47380870
69	Bile secretion_Homo sapiens_hsa04976	0.45926242
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.45257053
71	Protein export_Homo sapiens_hsa03060	0.44714357
72	Homologous recombination_Homo sapiens_hsa03440	0.44694927
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.44142202
74	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.44074014
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44061515
76	Metabolic pathways_Homo sapiens_hsa01100	0.41291310
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.40489140
78	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.38790074
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37125913
80	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.37051070
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.36982151
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.36062416
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.35320952
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.33951323
85	Melanogenesis_Homo sapiens_hsa04916	0.33902203
86	Gastric acid secretion_Homo sapiens_hsa04971	0.33156481
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32678246
88	Spliceosome_Homo sapiens_hsa03040	0.32435137
89	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32148727
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.31897616
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.31240690
92	Melanoma_Homo sapiens_hsa05218	0.30709975
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.30639115
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.30416367
95	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.30369568
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.30072582
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.29543032
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.28628121
99	Pancreatic secretion_Homo sapiens_hsa04972	0.25915933
100	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.25716973

FTH1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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