ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	6.10216246
2	neutrophil activation involved in immune response (GO:0002283)	4.85344712
3	platelet dense granule organization (GO:0060155)	4.20368625
4	DNA deamination (GO:0045006)	3.79031815
5	thrombin receptor signaling pathway (GO:0070493)	3.69973919
6	regulation of vitamin D biosynthetic process (GO:0060556)	3.61996365
7	cellular biogenic amine catabolic process (GO:0042402)	3.54069663
8	amine catabolic process (GO:0009310)	3.54069663
9	sulfur amino acid catabolic process (GO:0000098)	3.53645503
10	purine nucleotide salvage (GO:0032261)	3.50606287
11	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.48116627
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.48116627
13	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	3.42333159
14	neutrophil activation (GO:0042119)	3.40863622
15	granulocyte activation (GO:0036230)	3.35907126
16	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.29023251
17	adenosine metabolic process (GO:0046085)	3.26058638
18	behavioral response to nicotine (GO:0035095)	3.18886201
19	positive regulation of cAMP-mediated signaling (GO:0043950)	3.17221594
20	sequestering of actin monomers (GO:0042989)	3.14250143
21	positive regulation of mast cell activation (GO:0033005)	3.11478518
22	positive regulation of defense response to virus by host (GO:0002230)	3.10763177
23	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.09617316
24	positive regulation of endothelial cell differentiation (GO:0045603)	3.06005764
25	adaptation of signaling pathway (GO:0023058)	3.02854180
26	regulation of memory T cell differentiation (GO:0043380)	3.01270155
27	polyamine biosynthetic process (GO:0006596)	2.99003125
28	negative regulation of interleukin-1 beta production (GO:0032691)	2.97109350
29	negative regulation of heart rate (GO:0010459)	2.95659250
30	regulation of vitamin metabolic process (GO:0030656)	2.95654858
31	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.90397002
32	regulation of T-helper 1 cell differentiation (GO:0045625)	2.89817420
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.88910409
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.88910409
35	NADH dehydrogenase complex assembly (GO:0010257)	2.88910409
36	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.86479361
37	protein complex biogenesis (GO:0070271)	2.85886179
38	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	2.81736369
39	fusion of sperm to egg plasma membrane (GO:0007342)	2.80673592
40	cellular biogenic amine biosynthetic process (GO:0042401)	2.75797590
41	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.75434788
42	phagosome maturation (GO:0090382)	2.75093670
43	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.74678547
44	cysteine metabolic process (GO:0006534)	2.74336933
45	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.74217061
46	regulation of endothelial cell differentiation (GO:0045601)	2.71699756
47	polyamine metabolic process (GO:0006595)	2.69362304
48	negative regulation of interleukin-1 production (GO:0032692)	2.68893517
49	lipoxygenase pathway (GO:0019372)	2.68148717
50	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.67277816
51	cellular response to zinc ion (GO:0071294)	2.66189973
52	negative regulation of response to food (GO:0032096)	2.65121904
53	negative regulation of appetite (GO:0032099)	2.65121904
54	purine-containing compound salvage (GO:0043101)	2.64840078
55	amine biosynthetic process (GO:0009309)	2.62763021
56	positive regulation of mast cell degranulation (GO:0043306)	2.59334522
57	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.59334522
58	kynurenine metabolic process (GO:0070189)	2.58328321
59	response to xenobiotic stimulus (GO:0009410)	2.57165791
60	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.56445012
61	regulation of platelet activation (GO:0010543)	2.53969947
62	response to pheromone (GO:0019236)	2.52071874
63	tryptophan catabolic process (GO:0006569)	2.49884322
64	indole-containing compound catabolic process (GO:0042436)	2.49884322
65	indolalkylamine catabolic process (GO:0046218)	2.49884322
66	regulation of macrophage derived foam cell differentiation (GO:0010743)	2.49691668
67	positive regulation of T-helper 1 type immune response (GO:0002827)	2.49403538
68	preassembly of GPI anchor in ER membrane (GO:0016254)	2.48971601
69	cytidine deamination (GO:0009972)	2.47611654
70	cytidine metabolic process (GO:0046087)	2.47611654
71	cytidine catabolic process (GO:0006216)	2.47611654
72	regulation of integrin-mediated signaling pathway (GO:2001044)	2.45637836
73	negative regulation of lipid storage (GO:0010888)	2.42503327
74	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.40930183
75	leukocyte migration involved in inflammatory response (GO:0002523)	2.40060289
76	actin nucleation (GO:0045010)	2.39700772
77	indolalkylamine metabolic process (GO:0006586)	2.38757422
78	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.37613609
79	ATP hydrolysis coupled proton transport (GO:0015991)	2.37613609
80	negative regulation of mast cell activation (GO:0033004)	2.35718443
81	leukocyte degranulation (GO:0043299)	2.35567156
82	positive regulation of T cell apoptotic process (GO:0070234)	2.34135309
83	cellular response to nicotine (GO:0071316)	2.33403253
84	regulation of T-helper 1 type immune response (GO:0002825)	2.33348886
85	blood coagulation, intrinsic pathway (GO:0007597)	2.30642085
86	amino acid salvage (GO:0043102)	2.30095343
87	L-methionine salvage (GO:0071267)	2.30095343
88	L-methionine biosynthetic process (GO:0071265)	2.30095343
89	glycerophospholipid catabolic process (GO:0046475)	2.28567558
90	negative regulation of membrane potential (GO:0045837)	2.28350765
91	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.27866799
92	immunoglobulin mediated immune response (GO:0016064)	2.26178947
93	detection of light stimulus involved in visual perception (GO:0050908)	2.25566336
94	detection of light stimulus involved in sensory perception (GO:0050962)	2.25566336
95	regulation of plasminogen activation (GO:0010755)	2.25346552
96	interferon-gamma secretion (GO:0072643)	2.25156653
97	neuromuscular process controlling posture (GO:0050884)	2.25035087
98	negative regulation of interleukin-12 production (GO:0032695)	2.24934757
99	regulation of inflammatory response to antigenic stimulus (GO:0002861)	2.24084473
100	negative regulation of interleukin-17 production (GO:0032700)	2.23908889

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.84104108
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.27269445
3	IRF8_21731497_ChIP-ChIP_J774_Mouse	3.27282480
4	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	3.07305120
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.90688851
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.46219625
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.45304707
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.25615509
9	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.19954312
10	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.10633850
11	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.02301802
12	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.95410283
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.91194698
14	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.82736114
15	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.75573059
16	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.73242761
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.72878517
18	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.70715668
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.67957044
20	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.64812003
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.64348349
22	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.59571631
23	STAT1_20625510_ChIP-Seq_HELA_Human	1.56673459
24	VDR_22108803_ChIP-Seq_LS180_Human	1.52863191
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.50911683
26	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.46368787
27	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.44566291
28	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.43548088
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.42853866
30	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.41697910
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40260072
32	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.37041382
33	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.36206154
34	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.35654685
35	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.31501478
36	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.30959671
37	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.28018092
38	GBX2_23144817_ChIP-Seq_PC3_Human	1.27093869
39	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25319030
40	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25243402
41	BCL6_27268052_Chip-Seq_Bcells_Human	1.19212072
42	NANOG_20526341_ChIP-Seq_ESCs_Human	1.18613887
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18500163
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18500163
45	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.18339958
46	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16216756
47	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.15781172
48	AR_20517297_ChIP-Seq_VCAP_Human	1.14802473
49	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.12882556
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12120101
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12120101
52	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.10833283
53	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.09944012
54	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.09751577
55	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.07093288
56	GATA1_19941826_ChIP-Seq_K562_Human	1.06630650
57	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06519625
58	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.04807088
59	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04222404
60	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.04126030
61	SOX2_21211035_ChIP-Seq_LN229_Human	1.03372461
62	NCOR_22424771_ChIP-Seq_293T_Human	1.03007790
63	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.02436881
64	HTT_18923047_ChIP-ChIP_STHdh_Human	1.02371856
65	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.02234086
66	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.01785171
67	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.00763170
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00733628
69	GATA3_26560356_Chip-Seq_TH2_Human	0.99259645
70	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97043148
71	ERG_20517297_ChIP-Seq_VCAP_Human	0.96773023
72	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95899526
73	MYC_19829295_ChIP-Seq_ESCs_Human	0.95491467
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95063718
75	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.93589487
76	CTCF_20526341_ChIP-Seq_ESCs_Human	0.93073456
77	SPI1_23547873_ChIP-Seq_NB4_Human	0.92535048
78	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.92498266
79	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.91243002
80	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.89202162
81	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.89077990
82	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.88979124
83	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.88616745
84	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.86741856
85	GATA2_19941826_ChIP-Seq_K562_Human	0.85426266
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.84704553
87	SPI1_23127762_ChIP-Seq_K562_Human	0.84622668
88	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.84207427
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.83525326
90	P300_27268052_Chip-Seq_Bcells_Human	0.83010204
91	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.82623905
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.82403826
93	P300_19829295_ChIP-Seq_ESCs_Human	0.82391483
94	ERA_21632823_ChIP-Seq_H3396_Human	0.80661115
95	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.80657444
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.80552943
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.80416005
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.80293191
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.80076124
100	BCOR_27268052_Chip-Seq_Bcells_Human	0.79778521

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003724_increased_susceptibility_to	4.23559637
2	MP0005464_abnormal_platelet_physiology	4.16314407
3	MP0003303_peritoneal_inflammation	3.01058932
4	MP0008004_abnormal_stomach_pH	2.59419108
5	MP0002148_abnormal_hypersensitivity_rea	2.50039608
6	MP0000372_irregular_coat_pigmentation	2.45159504
7	MP0009764_decreased_sensitivity_to	2.29906998
8	MP0003186_abnormal_redox_activity	2.21906146
9	MP0005167_abnormal_blood-brain_barrier	2.19577750
10	MP0003806_abnormal_nucleotide_metabolis	2.17572020
11	MP0002138_abnormal_hepatobiliary_system	2.06773362
12	MP0005671_abnormal_response_to	2.04618604
13	MP0005360_urolithiasis	1.89693711
14	MP0009785_altered_susceptibility_to	1.89190280
15	MP0000343_altered_response_to	1.89007378
16	MP0003011_delayed_dark_adaptation	1.87145142
17	MP0002736_abnormal_nociception_after	1.85145597
18	MP0001835_abnormal_antigen_presentation	1.83430838
19	MP0005084_abnormal_gallbladder_morpholo	1.75352821
20	MP0000015_abnormal_ear_pigmentation	1.73644313
21	MP0002095_abnormal_skin_pigmentation	1.69080893
22	MP0004142_abnormal_muscle_tone	1.67910863
23	MP0005410_abnormal_fertilization	1.67873802
24	MP0003646_muscle_fatigue	1.65898355
25	MP0005000_abnormal_immune_tolerance	1.61971651
26	MP0008872_abnormal_physiological_respon	1.59718604
27	MP0000230_abnormal_systemic_arterial	1.56876384
28	MP0003879_abnormal_hair_cell	1.56775831
29	MP0003436_decreased_susceptibility_to	1.56321025
30	MP0003136_yellow_coat_color	1.56162635
31	MP0003195_calcinosis	1.54472023
32	MP0004147_increased_porphyrin_level	1.53906524
33	MP0005058_abnormal_lysosome_morphology	1.47628462
34	MP0001968_abnormal_touch/_nociception	1.45112370
35	MP0001533_abnormal_skeleton_physiology	1.39800601
36	MP0002139_abnormal_hepatobiliary_system	1.36558747
37	MP0005646_abnormal_pituitary_gland	1.35468612
38	MP0002653_abnormal_ependyma_morphology	1.32474467
39	MP0002723_abnormal_immune_serum	1.30676980
40	MP0009765_abnormal_xenobiotic_induced	1.30017319
41	MP0002735_abnormal_chemical_nociception	1.29879109
42	MP0001663_abnormal_digestive_system	1.29537416
43	MP0005174_abnormal_tail_pigmentation	1.29204507
44	MP0002419_abnormal_innate_immunity	1.29007544
45	MP0002876_abnormal_thyroid_physiology	1.26204493
46	MP0001545_abnormal_hematopoietic_system	1.25895337
47	MP0005397_hematopoietic_system_phenotyp	1.25895337
48	MP0002733_abnormal_thermal_nociception	1.22951112
49	MP0002938_white_spotting	1.22580703
50	MP0002837_dystrophic_cardiac_calcinosis	1.22528348
51	MP0005025_abnormal_response_to	1.21388429
52	MP0001800_abnormal_humoral_immune	1.18511453
53	MP0002452_abnormal_antigen_presenting	1.18404917
54	MP0001970_abnormal_pain_threshold	1.17992441
55	MP0001845_abnormal_inflammatory_respons	1.17874387
56	MP0001919_abnormal_reproductive_system	1.16455313
57	MP0000569_abnormal_digit_pigmentation	1.15293493
58	MP0009379_abnormal_foot_pigmentation	1.14360445
59	MP0004885_abnormal_endolymph	1.13338620
60	MP0003638_abnormal_response/metabolism_	1.11965541
61	MP0001905_abnormal_dopamine_level	1.11307607
62	MP0005551_abnormal_eye_electrophysiolog	1.09043083
63	MP0005075_abnormal_melanosome_morpholog	1.08113873
64	MP0006036_abnormal_mitochondrial_physio	1.06135729
65	MP0009763_increased_sensitivity_to	1.04606724
66	MP0006276_abnormal_autonomic_nervous	1.04137353
67	MP0005387_immune_system_phenotype	1.03647882
68	MP0001790_abnormal_immune_system	1.03647882
69	MP0006082_CNS_inflammation	1.03287038
70	MP0003172_abnormal_lysosome_physiology	1.00322301
71	MP0010329_abnormal_lipoprotein_level	0.98716202
72	MP0000371_diluted_coat_color	0.98455601
73	MP0010155_abnormal_intestine_physiology	0.97891693
74	MP0005408_hypopigmentation	0.97138121
75	MP0008469_abnormal_protein_level	0.96821086
76	MP0001542_abnormal_bone_strength	0.94792809
77	MP0008995_early_reproductive_senescence	0.93266469
78	MP0001819_abnormal_immune_cell	0.92916928
79	MP0002420_abnormal_adaptive_immunity	0.92147131
80	MP0003075_altered_response_to	0.89590243
81	MP0000685_abnormal_immune_system	0.87379754
82	MP0002272_abnormal_nervous_system	0.87205888
83	MP0005636_abnormal_mineral_homeostasis	0.86850042
84	MP0004019_abnormal_vitamin_homeostasis	0.86397873
85	MP0002277_abnormal_respiratory_mucosa	0.86129630
86	MP0005332_abnormal_amino_acid	0.84644079
87	MP0004130_abnormal_muscle_cell	0.84012765
88	MP0005171_absent_coat_pigmentation	0.83054491
89	MP0005253_abnormal_eye_physiology	0.82391500
90	MP0002102_abnormal_ear_morphology	0.81901608
91	MP0005389_reproductive_system_phenotype	0.80359067
92	MP0000465_gastrointestinal_hemorrhage	0.80299062
93	MP0003656_abnormal_erythrocyte_physiolo	0.78311399
94	MP0004510_myositis	0.77228132
95	MP0009046_muscle_twitch	0.76782250
96	MP0001756_abnormal_urination	0.73634351
97	MP0006072_abnormal_retinal_apoptosis	0.72196024
98	MP0001324_abnormal_eye_pigmentation	0.71384841
99	MP0002295_abnormal_pulmonary_circulatio	0.71069777
100	MP0004947_skin_inflammation	0.70856792

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Petechiae (HP:0000967)	4.70644685
2	Prolonged bleeding time (HP:0003010)	4.36777879
3	Purpura (HP:0000979)	4.34834240
4	Congenital sensorineural hearing impairment (HP:0008527)	3.90960943
5	Decreased central vision (HP:0007663)	3.84790464
6	Menorrhagia (HP:0000132)	3.61600372
7	Generalized aminoaciduria (HP:0002909)	3.56708044
8	Elevated erythrocyte sedimentation rate (HP:0003565)	3.47867661
9	Stomatitis (HP:0010280)	3.46334764
10	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.44004070
11	Abnormality of alanine metabolism (HP:0010916)	3.42294921
12	Hyperalaninemia (HP:0003348)	3.42294921
13	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.42294921
14	Acute necrotizing encephalopathy (HP:0006965)	3.41545084
15	Hyperlipoproteinemia (HP:0010980)	3.33493511
16	Agitation (HP:0000713)	3.29798399
17	Abnormal mitochondria in muscle tissue (HP:0008316)	3.20206963
18	Increased mean platelet volume (HP:0011877)	3.18252832
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.15647310
20	Polyphagia (HP:0002591)	3.13034070
21	Epistaxis (HP:0000421)	3.10066668
22	Acute encephalopathy (HP:0006846)	3.04459985
23	Abnormal platelet volume (HP:0011876)	2.93872598
24	Nausea (HP:0002018)	2.87250457
25	Progressive macrocephaly (HP:0004481)	2.84981656
26	Pendular nystagmus (HP:0012043)	2.80696207
27	Gingival bleeding (HP:0000225)	2.79274734
28	Mitochondrial inheritance (HP:0001427)	2.77757717
29	Abolished electroretinogram (ERG) (HP:0000550)	2.69732279
30	Episodic fever (HP:0001954)	2.62344284
31	Constricted visual fields (HP:0001133)	2.59336365
32	Hepatic necrosis (HP:0002605)	2.57935800
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.54142642
34	Abnormality of the costochondral junction (HP:0000919)	2.53760093
35	Hypomagnesemia (HP:0002917)	2.52036380
36	Hepatocellular necrosis (HP:0001404)	2.47621086
37	Attenuation of retinal blood vessels (HP:0007843)	2.42751313
38	Keratoconus (HP:0000563)	2.41755282
39	Increased corneal curvature (HP:0100692)	2.41755282
40	Abnormality of magnesium homeostasis (HP:0004921)	2.39169609
41	Increased CSF lactate (HP:0002490)	2.34294883
42	3-Methylglutaconic aciduria (HP:0003535)	2.31439122
43	Spontaneous hematomas (HP:0007420)	2.30234920
44	Abnormality of glycolipid metabolism (HP:0010969)	2.29634653
45	Abnormality of liposaccharide metabolism (HP:0010968)	2.29634653
46	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.29634653
47	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.21138549
48	Type 2 muscle fiber atrophy (HP:0003554)	2.17991277
49	Paralysis (HP:0003470)	2.15984994
50	Albinism (HP:0001022)	2.13644151
51	Vacuolated lymphocytes (HP:0001922)	2.11502626
52	Oligomenorrhea (HP:0000876)	2.11143484
53	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.10622686
54	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.10622686
55	Disinhibition (HP:0000734)	2.08721819
56	White forelock (HP:0002211)	2.07986629
57	Poikilocytosis (HP:0004447)	2.07407840
58	Optic disc pallor (HP:0000543)	2.06098428
59	Molar tooth sign on MRI (HP:0002419)	1.99089428
60	Abnormality of midbrain morphology (HP:0002418)	1.99089428
61	Disproportionate short-trunk short stature (HP:0003521)	1.98562894
62	Muscle fiber atrophy (HP:0100295)	1.96048683
63	Abnormal pupillary function (HP:0007686)	1.95809698
64	Increased serum ferritin (HP:0003281)	1.93796134
65	Abnormality of iron homeostasis (HP:0011031)	1.93451688
66	Cerebral edema (HP:0002181)	1.93044930
67	Abnormality of lateral ventricle (HP:0030047)	1.92803292
68	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.91800951
69	Congenital stationary night blindness (HP:0007642)	1.91063936
70	Patchy hypopigmentation of hair (HP:0011365)	1.90001449
71	Dyschromatopsia (HP:0007641)	1.88037413
72	Progressive neurologic deterioration (HP:0002344)	1.87828987
73	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.87374461
74	Hypoplasia of the fovea (HP:0007750)	1.87374461
75	Myositis (HP:0100614)	1.87235513
76	Metaphyseal irregularity (HP:0003025)	1.86750968
77	Hepatosplenomegaly (HP:0001433)	1.86143875
78	Conjunctival telangiectasia (HP:0000524)	1.85812177
79	Increased serum lactate (HP:0002151)	1.85419478
80	Renal Fanconi syndrome (HP:0001994)	1.84541903
81	Pachygyria (HP:0001302)	1.83621415
82	Abnormality of the prostate (HP:0008775)	1.83020845
83	Abnormality of the corticospinal tract (HP:0002492)	1.82423506
84	IgG deficiency (HP:0004315)	1.81594812
85	Psychosis (HP:0000709)	1.81077830
86	Lactic acidosis (HP:0003128)	1.80740233
87	Acanthocytosis (HP:0001927)	1.79646285
88	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.79617186
89	Abnormality of macrophages (HP:0004311)	1.78330586
90	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78257856
91	Anorexia (HP:0002039)	1.76259373
92	Abnormality of transition element cation homeostasis (HP:0011030)	1.75379013
93	Abnormal hemoglobin (HP:0011902)	1.74061863
94	Retrobulbar optic neuritis (HP:0100654)	1.72955873
95	Optic neuritis (HP:0100653)	1.72955873
96	Visual hallucinations (HP:0002367)	1.70704660
97	Increased IgM level (HP:0003496)	1.69773262
98	Lissencephaly (HP:0001339)	1.68911049
99	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.68622783
100	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.66696024

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	2.82900222
2	PIM2	2.43533842
3	TAOK3	2.35119350
4	EPHB2	2.25459815
5	TLK1	2.12945749
6	MAP4K2	2.12564348
7	MST4	2.12217955
8	EIF2AK1	2.06572827
9	MAP3K11	2.02490409
10	PINK1	2.01704867
11	ACVR1B	1.84055164
12	RIPK4	1.78215973
13	TIE1	1.78106401
14	BMPR2	1.72427199
15	BCKDK	1.71558996
16	IKBKB	1.63406200
17	ZAK	1.63059279
18	GRK1	1.62971698
19	TEC	1.60333815
20	DYRK2	1.57112148
21	NME2	1.55933671
22	MATK	1.55455138
23	MYLK	1.52147768
24	MINK1	1.44672665
25	SYK	1.44284600
26	FGR	1.43935514
27	MARK3	1.38255058
28	MAP3K3	1.32918511
29	LIMK1	1.31874289
30	WNK4	1.30297220
31	PNCK	1.29685845
32	CSF1R	1.28789011
33	STK16	1.28394501
34	GRK5	1.25969998
35	JAK3	1.25278071
36	IRAK3	1.23966984
37	MAP4K1	1.21415578
38	GRK7	1.19557091
39	ARAF	1.18683484
40	GRK6	1.18194409
41	TXK	1.15806298
42	ABL2	1.11066965
43	PLK2	1.08783501
44	NUAK1	1.08284114
45	BMX	1.06239882
46	TRIM28	1.05625315
47	BTK	1.03029298
48	ADRBK1	1.01956047
49	PTK2B	0.98563834
50	MAP3K12	0.95546520
51	KIT	0.94004349
52	SGK223	0.93403417
53	SGK494	0.93403417
54	DAPK3	0.92086653
55	STK39	0.89985568
56	TBK1	0.87691842
57	LYN	0.85944916
58	DDR2	0.84935151
59	BMPR1B	0.84410346
60	SGK2	0.82280175
61	IKBKE	0.80473028
62	MAPKAPK3	0.79461458
63	PRKCG	0.77826860
64	MAP3K5	0.77785858
65	ZAP70	0.77170903
66	CSK	0.73944102
67	TAOK2	0.72642818
68	MAP2K3	0.69904121
69	OXSR1	0.69300249
70	PHKG1	0.68895344
71	PHKG2	0.68895344
72	ERBB3	0.68624682
73	EPHA3	0.66895983
74	FES	0.66797299
75	PIM1	0.65441341
76	DAPK2	0.64249317
77	MAP2K1	0.64212714
78	PIK3CG	0.63959349
79	BLK	0.60682069
80	PAK1	0.60199937
81	DYRK3	0.59698912
82	MAPK13	0.59403978
83	PRKCD	0.57616284
84	MAP2K7	0.55448405
85	FRK	0.55097595
86	AURKA	0.54594711
87	CDK19	0.53424814
88	KDR	0.52731500
89	PRKACA	0.51376892
90	CSNK1G3	0.50566276
91	CAMK1	0.50288288
92	CSNK1G1	0.50132413
93	RPS6KA2	0.49475527
94	PRKCQ	0.48955545
95	RPS6KA6	0.48757264
96	PRKCA	0.47570729
97	WNK3	0.46918094
98	FER	0.46901207
99	ABL1	0.45481897
100	SGK3	0.44992949

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.26951744
2	Collecting duct acid secretion_Homo sapiens_hsa04966	3.01913347
3	Sulfur metabolism_Homo sapiens_hsa00920	2.82108051
4	Rheumatoid arthritis_Homo sapiens_hsa05323	2.78746978
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.78261440
6	Allograft rejection_Homo sapiens_hsa05330	2.76241140
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.72329352
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.55156110
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.31215133
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.21348841
11	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.18730642
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.17429589
13	Parkinsons disease_Homo sapiens_hsa05012	2.05676338
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.01549702
15	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.97095523
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.85300767
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.62009334
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.58995054
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.56932622
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.55802191
21	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.54040173
22	Phagosome_Homo sapiens_hsa04145	1.44099229
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31709131
24	Proteasome_Homo sapiens_hsa03050	1.26887561
25	Alzheimers disease_Homo sapiens_hsa05010	1.25987697
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.25632608
27	Platelet activation_Homo sapiens_hsa04611	1.24678677
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.24215574
29	Morphine addiction_Homo sapiens_hsa05032	1.21414722
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.20128151
31	Caffeine metabolism_Homo sapiens_hsa00232	1.17973489
32	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.11157148
33	Lysosome_Homo sapiens_hsa04142	1.09942149
34	Regulation of autophagy_Homo sapiens_hsa04140	1.06729800
35	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.06297254
36	GABAergic synapse_Homo sapiens_hsa04727	1.03321530
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.02728130
38	Leishmaniasis_Homo sapiens_hsa05140	1.01888057
39	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.01413259
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.00284971
41	Chemokine signaling pathway_Homo sapiens_hsa04062	0.97495825
42	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.97406215
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95805345
44	Ether lipid metabolism_Homo sapiens_hsa00565	0.95295059
45	Peroxisome_Homo sapiens_hsa04146	0.94919394
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.94296675
47	Viral myocarditis_Homo sapiens_hsa05416	0.93118632
48	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.92562404
49	Huntingtons disease_Homo sapiens_hsa05016	0.92073863
50	Mineral absorption_Homo sapiens_hsa04978	0.90755865
51	Serotonergic synapse_Homo sapiens_hsa04726	0.90534842
52	Vibrio cholerae infection_Homo sapiens_hsa05110	0.90198477
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.89972111
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.89938369
55	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.87833937
56	Primary immunodeficiency_Homo sapiens_hsa05340	0.86834651
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83061014
58	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.81567916
59	Glutathione metabolism_Homo sapiens_hsa00480	0.81005066
60	Fatty acid elongation_Homo sapiens_hsa00062	0.78969646
61	Malaria_Homo sapiens_hsa05144	0.78282658
62	Phototransduction_Homo sapiens_hsa04744	0.77913461
63	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.76491572
64	Tuberculosis_Homo sapiens_hsa05152	0.76105735
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75336158
66	Protein export_Homo sapiens_hsa03060	0.75227863
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.73944786
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73385961
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.72833672
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.70315489
71	One carbon pool by folate_Homo sapiens_hsa00670	0.68747692
72	Cardiac muscle contraction_Homo sapiens_hsa04260	0.65694485
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65325074
74	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.62944797
75	Galactose metabolism_Homo sapiens_hsa00052	0.61843591
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.59632958
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58925386
78	Pertussis_Homo sapiens_hsa05133	0.58123907
79	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.57692414
80	Olfactory transduction_Homo sapiens_hsa04740	0.55677080
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55440065
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54959444
83	Butanoate metabolism_Homo sapiens_hsa00650	0.54700443
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.54522484
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53598113
86	Osteoclast differentiation_Homo sapiens_hsa04380	0.51836133
87	Legionellosis_Homo sapiens_hsa05134	0.50997504
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50944887
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49581062
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48042178
91	Salmonella infection_Homo sapiens_hsa05132	0.47803959
92	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.47150001
93	Sulfur relay system_Homo sapiens_hsa04122	0.46191433
94	Shigellosis_Homo sapiens_hsa05131	0.44754837
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42359978
96	Metabolic pathways_Homo sapiens_hsa01100	0.41197749
97	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.40532649
98	Circadian entrainment_Homo sapiens_hsa04713	0.38810036
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38159121
100	Retinol metabolism_Homo sapiens_hsa00830	0.36661077

FTH1P20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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