ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of guanylate cyclase activity (GO:0031282)	5.10846752
2	NADH metabolic process (GO:0006734)	5.00319632
3	eosinophil chemotaxis (GO:0048245)	4.90634262
4	antibacterial humoral response (GO:0019731)	4.81821350
5	regulation of cellular extravasation (GO:0002691)	4.76138679
6	antimicrobial humoral response (GO:0019730)	4.60017468
7	eosinophil migration (GO:0072677)	4.40610961
8	positive regulation of respiratory burst (GO:0060267)	4.36819579
9	angiotensin maturation (GO:0002003)	4.33089482
10	positive regulation of pseudopodium assembly (GO:0031274)	4.15049593
11	positive regulation of guanylate cyclase activity (GO:0031284)	4.09020078
12	cytidine catabolic process (GO:0006216)	3.73119010
13	cytidine deamination (GO:0009972)	3.73119010
14	cytidine metabolic process (GO:0046087)	3.73119010
15	immunoglobulin mediated immune response (GO:0016064)	3.72852402
16	regulation of pseudopodium assembly (GO:0031272)	3.71206458
17	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.66266927
18	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.58102154
19	GDP-mannose metabolic process (GO:0019673)	3.49430394
20	regulation of triglyceride catabolic process (GO:0010896)	3.48408494
21	killing of cells of other organism (GO:0031640)	3.47658210
22	disruption of cells of other organism (GO:0044364)	3.47658210
23	ATP synthesis coupled proton transport (GO:0015986)	3.35124590
24	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.35124590
25	regulation of cGMP biosynthetic process (GO:0030826)	3.27450393
26	antigen processing and presentation of endogenous antigen (GO:0019883)	3.23391145
27	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.21710466
28	low-density lipoprotein particle remodeling (GO:0034374)	3.19163621
29	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.16705469
30	cellular response to zinc ion (GO:0071294)	3.16294628
31	epoxygenase P450 pathway (GO:0019373)	3.12191223
32	negative regulation of epidermal cell differentiation (GO:0045605)	3.11435207
33	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.04978737
34	T cell costimulation (GO:0031295)	3.04204346
35	antigen processing and presentation via MHC class Ib (GO:0002475)	3.04054445
36	fat-soluble vitamin biosynthetic process (GO:0042362)	3.02965350
37	regulation of antigen processing and presentation (GO:0002577)	3.01409823
38	lymphocyte costimulation (GO:0031294)	3.00150092
39	defense response to fungus (GO:0050832)	2.99088797
40	fructose metabolic process (GO:0006000)	2.98651963
41	cellular response to cadmium ion (GO:0071276)	2.98030632
42	positive regulation of antigen processing and presentation (GO:0002579)	2.97904519
43	receptor guanylyl cyclase signaling pathway (GO:0007168)	2.94389028
44	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.92893647
45	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.92083758
46	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.87630938
47	B cell mediated immunity (GO:0019724)	2.87044278
48	tryptophan catabolic process (GO:0006569)	2.84348005
49	indole-containing compound catabolic process (GO:0042436)	2.84348005
50	indolalkylamine catabolic process (GO:0046218)	2.84348005
51	DNA deamination (GO:0045006)	2.84317038
52	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.83723369
53	protein neddylation (GO:0045116)	2.81432007
54	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.81298345
55	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.80993723
56	interferon-gamma-mediated signaling pathway (GO:0060333)	2.79811741
57	arginine metabolic process (GO:0006525)	2.78359614
58	regulation of respiratory burst (GO:0060263)	2.77977859
59	regulation of cGMP metabolic process (GO:0030823)	2.77317966
60	negative regulation of leukocyte migration (GO:0002686)	2.77078222
61	xenobiotic catabolic process (GO:0042178)	2.75512157
62	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.73011239
63	regulation of vitamin metabolic process (GO:0030656)	2.72938952
64	bile acid and bile salt transport (GO:0015721)	2.72588641
65	intestinal absorption (GO:0050892)	2.71626267
66	dendritic cell chemotaxis (GO:0002407)	2.71226902
67	actin nucleation (GO:0045010)	2.70175543
68	peptide catabolic process (GO:0043171)	2.69027552
69	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.67513110
70	digestion (GO:0007586)	2.67252914
71	glutathione biosynthetic process (GO:0006750)	2.66040260
72	sulfation (GO:0051923)	2.65233644
73	regulation of cellular respiration (GO:0043457)	2.65035810
74	neutrophil activation involved in immune response (GO:0002283)	2.62560072
75	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.61719025
76	respiratory electron transport chain (GO:0022904)	2.60891438
77	kynurenine metabolic process (GO:0070189)	2.60763378
78	electron transport chain (GO:0022900)	2.60253228
79	negative regulation of mast cell activation (GO:0033004)	2.58449254
80	glutathione derivative biosynthetic process (GO:1901687)	2.57635408
81	glutathione derivative metabolic process (GO:1901685)	2.57635408
82	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.56094349
83	amine catabolic process (GO:0009310)	2.55551531
84	cellular biogenic amine catabolic process (GO:0042402)	2.55551531
85	positive regulation of cGMP biosynthetic process (GO:0030828)	2.55034295
86	regulation of T cell mediated cytotoxicity (GO:0001914)	2.52218526
87	L-ascorbic acid metabolic process (GO:0019852)	2.51612126
88	negative regulation of heart rate (GO:0010459)	2.51252945
89	drug metabolic process (GO:0017144)	2.49533345
90	cyclooxygenase pathway (GO:0019371)	2.48252501
91	nucleoside diphosphate biosynthetic process (GO:0009133)	2.47851150
92	nonribosomal peptide biosynthetic process (GO:0019184)	2.46885701
93	vitamin A metabolic process (GO:0006776)	2.45641962
94	leukotriene biosynthetic process (GO:0019370)	2.45156376
95	leukotriene metabolic process (GO:0006691)	2.44759742
96	glutathione metabolic process (GO:0006749)	2.44297169
97	drug catabolic process (GO:0042737)	2.44019845
98	platelet dense granule organization (GO:0060155)	2.42812301
99	positive regulation of monocyte chemotaxis (GO:0090026)	2.42039813
100	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.40447691

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.77929127
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.26255309
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.03262201
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.76691617
5	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.83665375
6	VDR_22108803_ChIP-Seq_LS180_Human	2.21514372
7	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.07303724
8	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.06344791
9	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.03436922
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.03048068
11	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.00965540
12	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.00656188
13	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.00229184
14	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.99545664
15	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.89073875
16	BCL6_27268052_Chip-Seq_Bcells_Human	1.84466046
17	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.80540977
18	STAT1_20625510_ChIP-Seq_HELA_Human	1.79940833
19	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.77036147
20	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.70068977
21	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.65252815
22	TAF2_19829295_ChIP-Seq_ESCs_Human	1.65196675
23	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.64623072
24	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.61280586
25	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.60472614
26	AR_20517297_ChIP-Seq_VCAP_Human	1.57882340
27	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.56195364
28	GATA4_25053715_ChIP-Seq_YYC3_Human	1.54111915
29	NANOG_20526341_ChIP-Seq_ESCs_Human	1.51418022
30	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.49486756
31	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.49362383
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.49362383
33	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.46376937
34	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.46176514
35	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.43408306
36	P300_27268052_Chip-Seq_Bcells_Human	1.40973765
37	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.40703809
38	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.40096370
39	ERG_20517297_ChIP-Seq_VCAP_Human	1.38118881
40	BCOR_27268052_Chip-Seq_Bcells_Human	1.37628450
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34901640
42	SA1_27219007_Chip-Seq_Bcells_Human	1.33169508
43	GATA3_26560356_Chip-Seq_TH2_Human	1.28922014
44	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.28085299
45	MYC_19829295_ChIP-Seq_ESCs_Human	1.27412287
46	SOX2_21211035_ChIP-Seq_LN229_Human	1.24119416
47	CTCF_20526341_ChIP-Seq_ESCs_Human	1.24024980
48	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.23998784
49	ZNF274_21170338_ChIP-Seq_K562_Hela	1.23555591
50	RUNX_20019798_ChIP-Seq_JUKART_Human	1.21718712
51	SPI1_23547873_ChIP-Seq_NB4_Human	1.21295679
52	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.20054680
53	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.19852041
54	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.19641457
55	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19528058
56	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.19045220
57	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.18093934
58	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.15620444
59	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.15530772
60	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.14641233
61	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.13192425
62	MYB_26560356_Chip-Seq_TH2_Human	1.11923460
63	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.11107748
64	P53_21459846_ChIP-Seq_SAOS-2_Human	1.11105596
65	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.10372637
66	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.10227337
67	ERA_21632823_ChIP-Seq_H3396_Human	1.10096473
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09773292
69	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.09417981
70	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09091284
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07536155
72	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.07175864
73	E2F1_20622854_ChIP-Seq_HELA_Human	1.07083466
74	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.07043971
75	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06548426
76	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.05238314
77	EGR1_19032775_ChIP-ChIP_M12_Human	1.04564725
78	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.03800047
79	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.01906502
80	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01048839
81	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00266732
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99518927
83	TP53_22573176_ChIP-Seq_HFKS_Human	0.99261578
84	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.99098433
85	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.98705299
86	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.97643400
87	CEBPB_22108803_ChIP-Seq_LS180_Human	0.97239512
88	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.96958786
89	NCOR_22424771_ChIP-Seq_293T_Human	0.95976587
90	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.94764126
91	RAC3_21632823_ChIP-Seq_H3396_Human	0.94314622
92	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.94115185
93	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.92519534
94	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.91686836
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91270601
96	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.91059344
97	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90640274
98	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90640274
99	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.90340774
100	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.89172318

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	4.89372327
2	MP0009379_abnormal_foot_pigmentation	3.80332840
3	MP0001835_abnormal_antigen_presentation	3.50370792
4	MP0010155_abnormal_intestine_physiology	3.35070211
5	MP0003806_abnormal_nucleotide_metabolis	3.10929207
6	MP0005671_abnormal_response_to	3.09236473
7	MP0002139_abnormal_hepatobiliary_system	3.05503562
8	MP0003724_increased_susceptibility_to	2.79081812
9	MP0001666_abnormal_nutrient_absorption	2.76545395
10	MP0004019_abnormal_vitamin_homeostasis	2.65167747
11	MP0005085_abnormal_gallbladder_physiolo	2.50248830
12	MP0009785_altered_susceptibility_to	2.30985591
13	MP0002148_abnormal_hypersensitivity_rea	2.29184783
14	MP0008875_abnormal_xenobiotic_pharmacok	2.25221337
15	MP0003436_decreased_susceptibility_to	2.20922230
16	MP0002876_abnormal_thyroid_physiology	2.11877412
17	MP0009764_decreased_sensitivity_to	2.04742739
18	MP0003866_abnormal_defecation	2.02612219
19	MP0009840_abnormal_foam_cell	1.97747208
20	MP0005464_abnormal_platelet_physiology	1.91090910
21	MP0005000_abnormal_immune_tolerance	1.91071737
22	MP0001800_abnormal_humoral_immune	1.81353617
23	MP0008872_abnormal_physiological_respon	1.80893754
24	MP0001845_abnormal_inflammatory_respons	1.80377477
25	MP0005365_abnormal_bile_salt	1.78912871
26	MP0006082_CNS_inflammation	1.77981918
27	MP0005387_immune_system_phenotype	1.76861984
28	MP0001790_abnormal_immune_system	1.76861984
29	MP0005025_abnormal_response_to	1.70650647
30	MP0004147_increased_porphyrin_level	1.69458716
31	MP0005645_abnormal_hypothalamus_physiol	1.62565601
32	MP0001873_stomach_inflammation	1.57464618
33	MP0002723_abnormal_immune_serum	1.56608346
34	MP0005166_decreased_susceptibility_to	1.55604853
35	MP0002452_abnormal_antigen_presenting	1.54013162
36	MP0000490_abnormal_crypts_of	1.52621915
37	MP0000685_abnormal_immune_system	1.51540812
38	MP0010329_abnormal_lipoprotein_level	1.50691517
39	MP0001819_abnormal_immune_cell	1.47458587
40	MP0003718_maternal_effect	1.45836063
41	MP0002420_abnormal_adaptive_immunity	1.42914417
42	MP0001664_abnormal_digestion	1.42047303
43	MP0009333_abnormal_splenocyte_physiolog	1.37851964
44	MP0001765_abnormal_ion_homeostasis	1.37565868
45	MP0002138_abnormal_hepatobiliary_system	1.37514014
46	MP0001533_abnormal_skeleton_physiology	1.35620355
47	MP0001663_abnormal_digestive_system	1.35557835
48	MP0003638_abnormal_response/metabolism_	1.33962770
49	MP0003303_peritoneal_inflammation	1.33828003
50	MP0009643_abnormal_urine_homeostasis	1.33563228
51	MP0000465_gastrointestinal_hemorrhage	1.33325999
52	MP0003879_abnormal_hair_cell	1.31560398
53	MP0002166_altered_tumor_susceptibility	1.30082331
54	MP0002419_abnormal_innate_immunity	1.28990662
55	MP0005332_abnormal_amino_acid	1.20364532
56	MP0008469_abnormal_protein_level	1.19863042
57	MP0003252_abnormal_bile_duct	1.15792861
58	MP0003183_abnormal_peptide_metabolism	1.14140484
59	MP0005636_abnormal_mineral_homeostasis	1.12939106
60	MP0001919_abnormal_reproductive_system	1.08946301
61	MP0001756_abnormal_urination	1.08035478
62	MP0002136_abnormal_kidney_physiology	1.03960284
63	MP0000477_abnormal_intestine_morphology	1.02766460
64	MP0005167_abnormal_blood-brain_barrier	0.98889223
65	MP0000716_abnormal_immune_system	0.97592276
66	MP0002006_tumorigenesis	0.96755351
67	MP0006036_abnormal_mitochondrial_physio	0.96120154
68	MP0000538_abnormal_urinary_bladder	0.95697411
69	MP0003195_calcinosis	0.95626630
70	MP0005381_digestive/alimentary_phenotyp	0.95532866
71	MP0005451_abnormal_body_composition	0.95528481
72	MP0001905_abnormal_dopamine_level	0.93501112
73	MP0008004_abnormal_stomach_pH	0.93310633
74	MP0001501_abnormal_sleep_pattern	0.92966727
75	MP0005535_abnormal_body_temperature	0.92779125
76	MP0009763_increased_sensitivity_to	0.91803013
77	MP0001764_abnormal_homeostasis	0.90341554
78	MP0006072_abnormal_retinal_apoptosis	0.90056504
79	MP0001188_hyperpigmentation	0.87978830
80	MP0000230_abnormal_systemic_arterial	0.87219760
81	MP0004947_skin_inflammation	0.86141859
82	MP0003075_altered_response_to	0.86078253
83	MP0002118_abnormal_lipid_homeostasis	0.85199162
84	MP0005319_abnormal_enzyme/_coenzyme	0.79242292
85	MP0001485_abnormal_pinna_reflex	0.78131613
86	MP0008775_abnormal_heart_ventricle	0.77733704
87	MP0009642_abnormal_blood_homeostasis	0.76268421
88	MP0001970_abnormal_pain_threshold	0.76114747
89	MP0005367_renal/urinary_system_phenotyp	0.75219780
90	MP0000516_abnormal_urinary_system	0.75219780
91	MP0001986_abnormal_taste_sensitivity	0.74073675
92	MP0002429_abnormal_blood_cell	0.74042584
93	MP0005165_increased_susceptibility_to	0.72303982
94	MP0005058_abnormal_lysosome_morphology	0.68779886
95	MP0009765_abnormal_xenobiotic_induced	0.68656497
96	MP0002398_abnormal_bone_marrow	0.67605537
97	MP0000343_altered_response_to	0.67529227
98	MP0005584_abnormal_enzyme/coenzyme_acti	0.63289102
99	MP0005410_abnormal_fertilization	0.62002085
100	MP0005174_abnormal_tail_pigmentation	0.61865736

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	5.53866632
2	Malnutrition (HP:0004395)	4.05901163
3	Systemic lupus erythematosus (HP:0002725)	3.71551927
4	Hydroxyprolinuria (HP:0003080)	3.60203055
5	Abnormality of proline metabolism (HP:0010907)	3.60203055
6	Nausea (HP:0002018)	3.59268095
7	Elevated erythrocyte sedimentation rate (HP:0003565)	3.42220264
8	Chronic diarrhea (HP:0002028)	3.27264720
9	Glycosuria (HP:0003076)	3.16550301
10	Abnormality of urine glucose concentration (HP:0011016)	3.16550301
11	Mitochondrial inheritance (HP:0001427)	3.13119417
12	Acute necrotizing encephalopathy (HP:0006965)	3.08932116
13	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.08708412
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.02687544
15	Hepatocellular necrosis (HP:0001404)	3.02419784
16	Abnormality of vitamin B metabolism (HP:0004340)	2.90598987
17	Hepatic necrosis (HP:0002605)	2.85946960
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.84538387
19	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.84538387
20	IgG deficiency (HP:0004315)	2.84396818
21	Petechiae (HP:0000967)	2.78898735
22	Congenital sensorineural hearing impairment (HP:0008527)	2.76686222
23	Congenital, generalized hypertrichosis (HP:0004540)	2.75233293
24	Acute encephalopathy (HP:0006846)	2.66249575
25	Increased CSF lactate (HP:0002490)	2.65920482
26	Hypoalbuminemia (HP:0003073)	2.64715866
27	Abnormal albumin level (HP:0012116)	2.64715866
28	Pustule (HP:0200039)	2.62870908
29	Xanthomatosis (HP:0000991)	2.53890154
30	Progressive macrocephaly (HP:0004481)	2.52842132
31	Increased muscle lipid content (HP:0009058)	2.52462094
32	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.52352623
33	Hypoproteinemia (HP:0003075)	2.51177507
34	Dicarboxylic aciduria (HP:0003215)	2.50394568
35	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.50394568
36	Increased intramyocellular lipid droplets (HP:0012240)	2.50132236
37	Posterior subcapsular cataract (HP:0007787)	2.47250592
38	Hyperphosphaturia (HP:0003109)	2.43475416
39	Abnormality of B cell number (HP:0010975)	2.43250891
40	Proximal tubulopathy (HP:0000114)	2.41586403
41	Widely patent fontanelles and sutures (HP:0004492)	2.39069089
42	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.36739183
43	Tongue fasciculations (HP:0001308)	2.36656792
44	Lethargy (HP:0001254)	2.35916023
45	Abnormality of alanine metabolism (HP:0010916)	2.29887666
46	Hyperalaninemia (HP:0003348)	2.29887666
47	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.29887666
48	Methylmalonic aciduria (HP:0012120)	2.29205867
49	Cerebral edema (HP:0002181)	2.28167237
50	Pancreatitis (HP:0001733)	2.27077903
51	Lipid accumulation in hepatocytes (HP:0006561)	2.26454585
52	Alkalosis (HP:0001948)	2.23306531
53	Vasculitis (HP:0002633)	2.23040890
54	Abnormality of serum amino acid levels (HP:0003112)	2.20822235
55	B lymphocytopenia (HP:0010976)	2.19980557
56	Microretrognathia (HP:0000308)	2.19567804
57	Abnormality of the prostate (HP:0008775)	2.15993489
58	Abnormality of magnesium homeostasis (HP:0004921)	2.15464861
59	Cerebral palsy (HP:0100021)	2.14931035
60	Decreased circulating renin level (HP:0003351)	2.14813747
61	Hyperlipoproteinemia (HP:0010980)	2.14657792
62	Alveolar cell carcinoma (HP:0006519)	2.14018931
63	Myositis (HP:0100614)	2.13128591
64	Hypobetalipoproteinemia (HP:0003563)	2.12699108
65	Abnormality of vitamin metabolism (HP:0100508)	2.11737281
66	Fat malabsorption (HP:0002630)	2.10723335
67	Lactic acidosis (HP:0003128)	2.10506456
68	Increased hepatocellular lipid droplets (HP:0006565)	2.10079141
69	Metabolic alkalosis (HP:0200114)	2.08378562
70	Exertional dyspnea (HP:0002875)	2.06992580
71	3-Methylglutaconic aciduria (HP:0003535)	2.06956964
72	Abnormality of the costochondral junction (HP:0000919)	2.03045180
73	Purpura (HP:0000979)	2.03015160
74	Glomerulonephritis (HP:0000099)	2.01140764
75	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00905884
76	Abnormal urine phosphate concentration (HP:0012599)	1.99933967
77	Obstructive lung disease (HP:0006536)	1.98859801
78	Chronic obstructive pulmonary disease (HP:0006510)	1.98859801
79	Generalized aminoaciduria (HP:0002909)	1.98656103
80	Pulmonary infiltrates (HP:0002113)	1.97018766
81	Muscle fibrillation (HP:0010546)	1.94817203
82	Decreased central vision (HP:0007663)	1.94523051
83	Conical tooth (HP:0000698)	1.93004082
84	Hypophosphatemia (HP:0002148)	1.92954200
85	Confusion (HP:0001289)	1.92406974
86	Hemoptysis (HP:0002105)	1.91988904
87	Encephalitis (HP:0002383)	1.91006479
88	Metabolic acidosis (HP:0001942)	1.87252427
89	Abnormality of macrophages (HP:0004311)	1.86992495
90	Stomatitis (HP:0010280)	1.86149882
91	Vomiting (HP:0002013)	1.85240560
92	Ileus (HP:0002595)	1.83850988
93	Acanthocytosis (HP:0001927)	1.83126420
94	Nephritis (HP:0000123)	1.82369131
95	Congenital stationary night blindness (HP:0007642)	1.79858780
96	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.79651395
97	Abnormality of complement system (HP:0005339)	1.79051329
98	Delayed epiphyseal ossification (HP:0002663)	1.78624644
99	Renal Fanconi syndrome (HP:0001994)	1.77310913
100	Steatorrhea (HP:0002570)	1.77186629

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K12	3.52351015
2	GRK6	3.13404524
3	MYLK	2.94784566
4	CDK19	2.91002105
5	NUAK1	2.77673412
6	BMPR2	2.61144145
7	ACVR1B	2.58143227
8	TLK1	2.43040691
9	TAOK3	2.24530054
10	TESK2	2.16327785
11	MAP4K1	2.03075482
12	BCKDK	1.95443597
13	ILK	1.92999372
14	GRK1	1.91306057
15	MST4	1.89427730
16	TXK	1.89427051
17	IKBKB	1.74393984
18	MAP4K2	1.72767411
19	KDR	1.67591822
20	TBK1	1.65856128
21	ADRBK2	1.59683906
22	MAP3K11	1.48857660
23	IKBKE	1.41057106
24	ERN1	1.37541591
25	CSF1R	1.34906059
26	RIPK4	1.31317952
27	EPHB2	1.28498545
28	OXSR1	1.26967121
29	PRKG2	1.26002585
30	SYK	1.25915964
31	LYN	1.20547667
32	MAP2K2	1.19649863
33	TESK1	1.18705809
34	TEC	1.10373937
35	KIT	1.09165294
36	ERBB3	1.09137356
37	TIE1	1.08384994
38	DAPK3	1.07940263
39	LCK	1.00845271
40	BTK	0.99420421
41	ITK	0.97663148
42	WNK4	0.96918034
43	PIM2	0.96645757
44	FRK	0.94971821
45	DAPK2	0.94008344
46	PDK2	0.93574049
47	FES	0.92627096
48	ABL2	0.91912140
49	MUSK	0.84296505
50	DAPK1	0.83755000
51	DYRK2	0.82910794
52	EPHA2	0.79914202
53	JAK3	0.79852799
54	GRK5	0.79673609
55	ZAK	0.79247154
56	STK16	0.77728983
57	TRPM7	0.75870111
58	MATK	0.75725562
59	CSK	0.75347709
60	LIMK1	0.74053995
61	PIM1	0.72792925
62	PRKCA	0.71683944
63	PRKCQ	0.70939823
64	FLT3	0.70117647
65	MAPKAPK5	0.69092874
66	WNK3	0.68956222
67	PIK3CG	0.67091693
68	MST1R	0.64623997
69	ZAP70	0.63161894
70	BLK	0.62768454
71	PRKACG	0.62368957
72	BMX	0.61022844
73	INSRR	0.60324881
74	PTK2B	0.58751909
75	PTK6	0.58565183
76	ERBB2	0.57233793
77	RPS6KA5	0.55277267
78	JAK1	0.54981053
79	PRKCE	0.54344518
80	MAP3K14	0.52916174
81	IGF1R	0.52017722
82	SIK3	0.49925699
83	MAPKAPK3	0.49042406
84	PRKACA	0.48702638
85	PAK1	0.48565207
86	CSNK1G3	0.48525062
87	GRK7	0.48274231
88	PRKCD	0.48218290
89	TYK2	0.47989191
90	EIF2AK3	0.47763290
91	MAP2K7	0.47174958
92	MARK3	0.46522492
93	CAMKK2	0.44451474
94	PRKG1	0.44122645
95	MAPK13	0.43985508
96	ABL1	0.43504550
97	MINK1	0.43066203
98	ADRBK1	0.41447432
99	TRIM28	0.41165711
100	PRKCZ	0.38082661

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.77140375
2	Allograft rejection_Homo sapiens_hsa05330	3.57770782
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.57108399
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.44629059
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.38587849
6	Caffeine metabolism_Homo sapiens_hsa00232	3.02802076
7	Fat digestion and absorption_Homo sapiens_hsa04975	3.00464631
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.85353471
9	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.67920712
10	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.35287119
11	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.28202008
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.10196885
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.88165571
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.85314214
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.83279540
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82642068
17	Rheumatoid arthritis_Homo sapiens_hsa05323	1.75653754
18	Sulfur metabolism_Homo sapiens_hsa00920	1.75383936
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.72865970
20	Viral myocarditis_Homo sapiens_hsa05416	1.62602670
21	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.55257438
22	Mineral absorption_Homo sapiens_hsa04978	1.50738742
23	Renin-angiotensin system_Homo sapiens_hsa04614	1.48858396
24	Parkinsons disease_Homo sapiens_hsa05012	1.44046066
25	Leishmaniasis_Homo sapiens_hsa05140	1.39030448
26	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.35725362
27	Glutathione metabolism_Homo sapiens_hsa00480	1.32396441
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.29136091
29	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.23103215
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.21678264
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.21042389
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.20291345
33	Proteasome_Homo sapiens_hsa03050	1.04915311
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.03431311
35	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.02847179
36	Glycerolipid metabolism_Homo sapiens_hsa00561	1.02706170
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.01395781
38	Arginine biosynthesis_Homo sapiens_hsa00220	0.99949873
39	Histidine metabolism_Homo sapiens_hsa00340	0.96446406
40	Alzheimers disease_Homo sapiens_hsa05010	0.93987066
41	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.91365915
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88452635
43	Retinol metabolism_Homo sapiens_hsa00830	0.88334492
44	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.88006183
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87319778
46	Protein digestion and absorption_Homo sapiens_hsa04974	0.85138232
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.78454693
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.77696060
49	PPAR signaling pathway_Homo sapiens_hsa03320	0.75467023
50	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.74630350
51	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.73637797
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.72164176
53	Huntingtons disease_Homo sapiens_hsa05016	0.71287721
54	Tuberculosis_Homo sapiens_hsa05152	0.69739472
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68081775
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.66668895
57	Ribosome_Homo sapiens_hsa03010	0.65690821
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.65574393
59	Phagosome_Homo sapiens_hsa04145	0.65024194
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61057093
61	Toxoplasmosis_Homo sapiens_hsa05145	0.60479919
62	Peroxisome_Homo sapiens_hsa04146	0.59315149
63	Pertussis_Homo sapiens_hsa05133	0.58941435
64	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.57217684
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56860634
66	Phototransduction_Homo sapiens_hsa04744	0.56494343
67	Pancreatic secretion_Homo sapiens_hsa04972	0.55214893
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55084064
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55002631
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53635920
71	Protein export_Homo sapiens_hsa03060	0.50516849
72	Herpes simplex infection_Homo sapiens_hsa05168	0.48295506
73	Nitrogen metabolism_Homo sapiens_hsa00910	0.46700506
74	Fatty acid degradation_Homo sapiens_hsa00071	0.46202451
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.44973574
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43558374
77	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.43495086
78	Bile secretion_Homo sapiens_hsa04976	0.41071503
79	Regulation of autophagy_Homo sapiens_hsa04140	0.40337405
80	Influenza A_Homo sapiens_hsa05164	0.39460980
81	Metabolic pathways_Homo sapiens_hsa01100	0.33675534
82	Chemokine signaling pathway_Homo sapiens_hsa04062	0.33154603
83	Sulfur relay system_Homo sapiens_hsa04122	0.32088297
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.31603942
85	Galactose metabolism_Homo sapiens_hsa00052	0.30117509
86	Butanoate metabolism_Homo sapiens_hsa00650	0.30034619
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.29988489
88	Salmonella infection_Homo sapiens_hsa05132	0.29897609
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26455128
90	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.25071540
91	Lysosome_Homo sapiens_hsa04142	0.25040885
92	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.23857854
93	Vibrio cholerae infection_Homo sapiens_hsa05110	0.22973913
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.21673474
95	Salivary secretion_Homo sapiens_hsa04970	0.21592818
96	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.21386636
97	RNA polymerase_Homo sapiens_hsa03020	0.20443085
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.18020771
99	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.16876162
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.16801383

FTH1P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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