FTH1P22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)9.80527726
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)9.80527726
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.00034013
4negative T cell selection (GO:0043383)6.26326849
5regulation of natural killer cell mediated cytotoxicity (GO:0042269)6.21615130
6regulation of natural killer cell mediated immunity (GO:0002715)6.21615130
7negative thymic T cell selection (GO:0045060)6.10890131
8positive regulation of natural killer cell mediated immunity (GO:0002717)5.81798361
9positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.50370214
10negative regulation of lymphocyte mediated immunity (GO:0002707)5.39527758
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.36822911
12cellular response to interleukin-15 (GO:0071350)5.29849123
13response to interleukin-15 (GO:0070672)5.28420682
14negative regulation of leukocyte mediated immunity (GO:0002704)5.17437304
15T cell migration (GO:0072678)5.07144197
16regulation of hypersensitivity (GO:0002883)5.00751978
17thymic T cell selection (GO:0045061)4.98964286
18leukocyte aggregation (GO:0070486)4.96982479
19activated T cell proliferation (GO:0050798)4.88887774
20regulation of B cell receptor signaling pathway (GO:0050855)4.86557453
21positive thymic T cell selection (GO:0045059)4.69090754
22regulation of leukocyte mediated cytotoxicity (GO:0001910)4.63473114
23positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.60808045
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.55512117
25positive regulation of gamma-delta T cell activation (GO:0046645)4.43934672
26T cell selection (GO:0045058)4.43881893
27negative regulation of innate immune response (GO:0045824)4.42979036
28negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.37811506
29positive T cell selection (GO:0043368)4.37238022
30antigen processing and presentation of endogenous antigen (GO:0019883)4.31281456
31negative regulation of T-helper cell differentiation (GO:0045623)4.30657988
32negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.30657988
33regulation of T cell receptor signaling pathway (GO:0050856)4.23433159
34regulation of cell killing (GO:0031341)4.13917513
35positive regulation of antigen processing and presentation (GO:0002579)4.12825691
36positive regulation of cell killing (GO:0031343)4.12753989
37interferon-gamma production (GO:0032609)4.11750947
38positive regulation of alpha-beta T cell proliferation (GO:0046641)4.06049336
39dendritic cell chemotaxis (GO:0002407)4.04625743
40regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.01669717
41regulation of alpha-beta T cell proliferation (GO:0046640)3.96380041
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.82116035
43lymphocyte migration (GO:0072676)3.81460680
44negative regulation of alpha-beta T cell activation (GO:0046636)3.72565041
45regulation of dendritic cell antigen processing and presentation (GO:0002604)3.68357334
46negative regulation of T cell mediated immunity (GO:0002710)3.62601397
47positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.62315822
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.62085896
49positive regulation of interleukin-4 production (GO:0032753)3.58518539
50regulation of gamma-delta T cell differentiation (GO:0045586)3.54623286
51dendritic cell migration (GO:0036336)3.54164258
52natural killer cell differentiation (GO:0001779)3.48687530
53cellular extravasation (GO:0045123)3.46222631
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.43652799
55regulation of regulatory T cell differentiation (GO:0045589)3.43340682
56tolerance induction (GO:0002507)3.38826541
57regulation of gamma-delta T cell activation (GO:0046643)3.36881315
58regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.35389084
59cellular defense response (GO:0006968)3.33463044
60positive regulation of humoral immune response (GO:0002922)3.32594958
61antigen processing and presentation via MHC class Ib (GO:0002475)3.32080867
62negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.29224605
63regulation of T cell mediated cytotoxicity (GO:0001914)3.26332820
64positive regulation of DNA recombination (GO:0045911)3.26318159
65regulation of antigen processing and presentation (GO:0002577)3.26311227
66lymphocyte chemotaxis (GO:0048247)3.25887274
67negative regulation of T cell apoptotic process (GO:0070233)3.24563377
68negative regulation of type 2 immune response (GO:0002829)3.23259351
69T cell receptor signaling pathway (GO:0050852)3.23093007
70mast cell activation (GO:0045576)3.22322353
71negative regulation of mast cell activation (GO:0033004)3.22008505
72negative regulation of adaptive immune response (GO:0002820)3.21335748
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.20042738
74regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.18193050
75cytolysis (GO:0019835)3.17729489
76negative regulation of phagocytosis (GO:0050765)3.17480714
77negative regulation of DNA-templated transcription, elongation (GO:0032785)3.17324251
78positive regulation of lymphocyte mediated immunity (GO:0002708)3.16847507
79negative regulation of cAMP-mediated signaling (GO:0043951)3.14202574
80positive regulation of calcium-mediated signaling (GO:0050850)3.10313968
81regulation of interleukin-1 beta secretion (GO:0050706)3.10108975
82chemokine-mediated signaling pathway (GO:0070098)3.08554109
83neutrophil activation involved in immune response (GO:0002283)3.07469802
84negative regulation of alpha-beta T cell differentiation (GO:0046639)3.06188745
85regulation of alpha-beta T cell activation (GO:0046634)3.06003388
86regulation of lymphocyte mediated immunity (GO:0002706)3.02961628
87natural killer cell activation (GO:0030101)3.01289055
88antigen receptor-mediated signaling pathway (GO:0050851)3.00994123
89regulation of T-helper 1 type immune response (GO:0002825)2.97565123
90interferon-gamma secretion (GO:0072643)2.97209228
91adaptation of signaling pathway (GO:0023058)2.94569813
92negative regulation of interleukin-12 production (GO:0032695)2.94545908
93regulation of B cell differentiation (GO:0045577)2.93791301
94regulation of leukocyte mediated immunity (GO:0002703)2.89203834
95positive regulation of granulocyte differentiation (GO:0030854)2.87724355
96regulation of interleukin-4 production (GO:0032673)2.87411099
97positive regulation of isotype switching (GO:0045830)2.86145118
98neutrophil activation (GO:0042119)2.85709868
99positive regulation of leukocyte mediated immunity (GO:0002705)2.84762022
100regulation of T-helper 1 cell differentiation (GO:0045625)2.82879456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.20664985
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.51224035
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.33344334
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.37839182
5RUNX_20019798_ChIP-Seq_JUKART_Human4.10400649
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.98988631
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.43049941
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.31765810
9MYB_26560356_Chip-Seq_TH2_Human3.07841334
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.04159538
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.97415791
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.83625339
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82764945
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50509953
15UTX_26944678_Chip-Seq_JUKART_Human2.48511500
16GATA3_27048872_Chip-Seq_THYMUS_Human2.40572668
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.38564002
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34056333
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.31434410
20MYB_26560356_Chip-Seq_TH1_Human2.29994669
21GATA3_26560356_Chip-Seq_TH2_Human2.29626259
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.24519793
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.14244571
24SCL_19346495_ChIP-Seq_HPC-7_Human2.04211741
25MAF_26560356_Chip-Seq_TH1_Human2.04096991
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96867312
27SPI1_23547873_ChIP-Seq_NB4_Human1.91679969
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84846274
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82907173
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.75933338
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.74195205
32MAF_26560356_Chip-Seq_TH2_Human1.73009799
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.63012491
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60779013
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59915904
36CIITA_25753668_ChIP-Seq_RAJI_Human1.55262712
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52905944
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51768736
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47212011
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41773451
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39564146
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37201100
43SPI1_23127762_ChIP-Seq_K562_Human1.32508191
44BCL6_27268052_Chip-Seq_Bcells_Human1.27309534
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24458123
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18954441
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18742912
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.18561560
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17894842
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.17542294
51CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16610887
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15020103
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14098160
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08685108
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08583375
56VDR_23849224_ChIP-Seq_CD4+_Human1.06187628
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02832457
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00120190
59FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99801696
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99661983
61VDR_24763502_ChIP-Seq_THP-1_Human0.99448483
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98412873
63VDR_24787735_ChIP-Seq_THP-1_Human0.97204271
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96305991
65SPI1_20517297_ChIP-Seq_HL60_Human0.95482652
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95260025
67BCOR_27268052_Chip-Seq_Bcells_Human0.94777521
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94561505
69RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91997415
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91496585
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91236427
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90985388
73GATA1_19941826_ChIP-Seq_K562_Human0.89538000
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88907420
75FOXP3_21729870_ChIP-Seq_TREG_Human0.87850062
76IRF1_19129219_ChIP-ChIP_H3396_Human0.87350847
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86803178
78VDR_21846776_ChIP-Seq_THP-1_Human0.86780010
79RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86050842
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85047878
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.84651370
82GATA3_26560356_Chip-Seq_TH1_Human0.84550261
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84438386
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84307111
85P300_27268052_Chip-Seq_Bcells_Human0.83987140
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83573760
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82869972
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82607027
89NFE2_27457419_Chip-Seq_LIVER_Mouse0.82273273
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81918341
91PU_27001747_Chip-Seq_BMDM_Mouse0.81488063
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81139785
93MYC_22102868_ChIP-Seq_BL_Human0.79944876
94TCF7_22412390_ChIP-Seq_EML_Mouse0.79620039
95ELK4_26923725_Chip-Seq_MESODERM_Mouse0.77313219
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75923443
97NANOG_20526341_ChIP-Seq_ESCs_Human0.75550146
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74840232
99SA1_27219007_Chip-Seq_Bcells_Human0.74252614
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73779053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.74930385
2MP0001835_abnormal_antigen_presentation4.88582884
3MP0003724_increased_susceptibility_to3.51851144
4MP0006082_CNS_inflammation3.45482765
5MP0003436_decreased_susceptibility_to3.30333466
6MP0005000_abnormal_immune_tolerance3.29662588
7MP0001800_abnormal_humoral_immune3.21236427
8MP0002148_abnormal_hypersensitivity_rea2.95238005
9MP0005025_abnormal_response_to2.77306161
10MP0002420_abnormal_adaptive_immunity2.76750249
11MP0002723_abnormal_immune_serum2.74503577
12MP0001819_abnormal_immune_cell2.74113530
13MP0003763_abnormal_thymus_physiology2.71362093
14MP0009785_altered_susceptibility_to2.69831715
15MP0001790_abnormal_immune_system2.60082968
16MP0005387_immune_system_phenotype2.60082968
17MP0002452_abnormal_antigen_presenting2.59872544
18MP0009333_abnormal_splenocyte_physiolog2.46498869
19MP0002419_abnormal_innate_immunity2.35074227
20MP0000685_abnormal_immune_system2.23094438
21MP0005464_abnormal_platelet_physiology2.14789921
22MP0003866_abnormal_defecation2.14647078
23MP0002398_abnormal_bone_marrow2.14191661
24MP0010155_abnormal_intestine_physiology2.05607777
25MP0002166_altered_tumor_susceptibility2.03010674
26MP0000716_abnormal_immune_system2.02903744
27MP0002163_abnormal_gland_morphology2.02027078
28MP0004381_abnormal_hair_follicle1.99347144
29MP0000689_abnormal_spleen_morphology1.88580972
30MP0000703_abnormal_thymus_morphology1.84322941
31MP0001845_abnormal_inflammatory_respons1.79319489
32MP0003448_altered_tumor_morphology1.79161174
33MP0003045_fibrosis1.76663075
34MP0002006_tumorigenesis1.75449325
35MP0002722_abnormal_immune_system1.75206509
36MP0002405_respiratory_system_inflammati1.72157456
37MP0005379_endocrine/exocrine_gland_phen1.59020762
38MP0002429_abnormal_blood_cell1.57604778
39MP0004947_skin_inflammation1.56150097
40MP0008872_abnormal_physiological_respon1.53361721
41MP0005310_abnormal_salivary_gland1.48015351
42MP0005075_abnormal_melanosome_morpholog1.45364288
43MP0001533_abnormal_skeleton_physiology1.43217176
44MP0008469_abnormal_protein_level1.38692488
45MP0000465_gastrointestinal_hemorrhage1.36993408
46MP0005083_abnormal_biliary_tract1.31482933
47MP0003183_abnormal_peptide_metabolism1.31116297
48MP0003011_delayed_dark_adaptation1.27859379
49MP0003300_gastrointestinal_ulcer1.24200964
50MP0001986_abnormal_taste_sensitivity1.23192844
51MP0003303_peritoneal_inflammation1.18482349
52MP0000858_altered_metastatic_potential1.17668934
53MP0001348_abnormal_lacrimal_gland1.14814730
54MP0009764_decreased_sensitivity_to1.12096789
55MP0002396_abnormal_hematopoietic_system1.05051659
56MP0004043_abnormal_pH_regulation1.02863867
57MP0004142_abnormal_muscle_tone1.00690999
58MP0003806_abnormal_nucleotide_metabolis1.00296076
59MP0010307_abnormal_tumor_latency0.99303168
60MP0002019_abnormal_tumor_incidence0.95093006
61MP0001727_abnormal_embryo_implantation0.93716611
62MP0008873_increased_physiological_sensi0.92039284
63MP0009763_increased_sensitivity_to0.91084007
64MP0005166_decreased_susceptibility_to0.87597685
65MP0002132_abnormal_respiratory_system0.87417902
66MP0002933_joint_inflammation0.82298489
67MP0000490_abnormal_crypts_of0.81180955
68MP0000015_abnormal_ear_pigmentation0.80218624
69MP0001661_extended_life_span0.79826703
70MP0002693_abnormal_pancreas_physiology0.77742296
71MP0001873_stomach_inflammation0.76840684
72MP0002009_preneoplasia0.74988636
73MP0001346_abnormal_lacrimal_gland0.74094030
74MP0002998_abnormal_bone_remodeling0.72850270
75MP0009278_abnormal_bone_marrow0.72311950
76MP0005319_abnormal_enzyme/_coenzyme0.70986628
77MP0004130_abnormal_muscle_cell0.70116987
78MP0001851_eye_inflammation0.68673478
79MP0004883_abnormal_blood_vessel0.63882068
80MP0005174_abnormal_tail_pigmentation0.63542021
81MP0002277_abnormal_respiratory_mucosa0.62782219
82MP0001853_heart_inflammation0.61662266
83MP0003172_abnormal_lysosome_physiology0.60954958
84MP0000343_altered_response_to0.57063166
85MP0004145_abnormal_muscle_electrophysio0.56491179
86MP0005390_skeleton_phenotype0.56046233
87MP0001764_abnormal_homeostasis0.55587652
88MP0004808_abnormal_hematopoietic_stem0.54296261
89MP0001765_abnormal_ion_homeostasis0.53591039
90MP0003252_abnormal_bile_duct0.53527222
91MP0002138_abnormal_hepatobiliary_system0.52968736
92MP0002168_other_aberrant_phenotype0.52513654
93MP0010329_abnormal_lipoprotein_level0.50961046
94MP0003191_abnormal_cellular_cholesterol0.50855125
95MP0009642_abnormal_blood_homeostasis0.50263757
96MP0001663_abnormal_digestive_system0.49538310
97MP0005085_abnormal_gallbladder_physiolo0.48576708
98MP0003690_abnormal_glial_cell0.47897496
99MP0004134_abnormal_chest_morphology0.47520683
100MP0008961_abnormal_basal_metabolism0.47446516

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.14561077
2Myositis (HP:0100614)5.13269856
3Hypoproteinemia (HP:0003075)5.00997527
4T lymphocytopenia (HP:0005403)4.85441559
5Abnormality of T cell number (HP:0011839)4.76990603
6Panhypogammaglobulinemia (HP:0003139)4.38638815
7Recurrent bacterial skin infections (HP:0005406)4.33249267
8Encephalitis (HP:0002383)4.31737000
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.29663285
10Stomatitis (HP:0010280)4.10276939
11Elevated erythrocyte sedimentation rate (HP:0003565)4.07168453
12Abnormality of T cells (HP:0002843)4.05174965
13Abnormality of macrophages (HP:0004311)3.94124325
14Renal cortical cysts (HP:0000803)3.89058283
15Eczematoid dermatitis (HP:0000976)3.87726964
16Increased IgM level (HP:0003496)3.80961201
17Recurrent abscess formation (HP:0002722)3.74747013
18Hemiplegia (HP:0002301)3.67072360
19IgG deficiency (HP:0004315)3.58141667
20J-shaped sella turcica (HP:0002680)3.52494991
21Severe combined immunodeficiency (HP:0004430)3.43373332
22Meningitis (HP:0001287)3.42725666
23Alveolar cell carcinoma (HP:0006519)3.09327727
24Abnormality of T cell physiology (HP:0011840)3.06950671
25Recurrent skin infections (HP:0001581)2.99643724
26Retrobulbar optic neuritis (HP:0100654)2.98714548
27Optic neuritis (HP:0100653)2.98714548
28Prolonged bleeding time (HP:0003010)2.93874115
29Autoimmune hemolytic anemia (HP:0001890)2.92767172
30Recurrent fungal infections (HP:0002841)2.89328198
31Petechiae (HP:0000967)2.88658879
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.83659666
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.83659666
34Chronic diarrhea (HP:0002028)2.82350141
35Gastrointestinal infarctions (HP:0005244)2.82051487
36Joint swelling (HP:0001386)2.77102566
37Chest pain (HP:0100749)2.75541867
38Neoplasm of the tracheobronchial system (HP:0100552)2.73862679
39Orchitis (HP:0100796)2.68010920
40Increased serum ferritin (HP:0003281)2.66930365
41Abnormality of iron homeostasis (HP:0011031)2.63807074
42Combined immunodeficiency (HP:0005387)2.63611860
43Obstructive lung disease (HP:0006536)2.53767943
44Chronic obstructive pulmonary disease (HP:0006510)2.53767943
45Pulmonary infiltrates (HP:0002113)2.52978916
46Increased CSF protein (HP:0002922)2.51676710
47Abnormality of transition element cation homeostasis (HP:0011030)2.47011256
48Mediastinal lymphadenopathy (HP:0100721)2.46341642
49Tetraplegia (HP:0002445)2.45712375
50Epistaxis (HP:0000421)2.41146726
51Inflammation of the large intestine (HP:0002037)2.40829312
52Gingival bleeding (HP:0000225)2.39674413
53Aplastic anemia (HP:0001915)2.38478639
54Abnormality of eosinophils (HP:0001879)2.35818528
55Purpura (HP:0000979)2.34256346
56Elfin facies (HP:0004428)2.33463750
57IgM deficiency (HP:0002850)2.32967131
58Abnormality of the renal cortex (HP:0011035)2.31837751
59Hypochromic anemia (HP:0001931)2.31807614
60Hypergammaglobulinemia (HP:0010702)2.30879940
61Eosinophilia (HP:0001880)2.30133080
62Chronic mucocutaneous candidiasis (HP:0002728)2.27449565
63Recurrent cutaneous fungal infections (HP:0011370)2.27449565
64Spontaneous hematomas (HP:0007420)2.26945512
65Leukocytosis (HP:0001974)2.26728134
66Abnormality of the prostate (HP:0008775)2.24928243
673-Methylglutaconic aciduria (HP:0003535)2.23643200
68Granulocytopenia (HP:0001913)2.23458435
69Hyperacusis (HP:0010780)2.23078058
70Acute hepatic failure (HP:0006554)2.22698936
71Chronic hepatic failure (HP:0100626)2.20185109
72Vasculitis (HP:0002633)2.20134484
73Renovascular hypertension (HP:0100817)2.17026998
74Lymphoma (HP:0002665)2.16397168
75Recurrent viral infections (HP:0004429)2.15818184
76Gastrointestinal inflammation (HP:0004386)2.13910973
77Bile duct proliferation (HP:0001408)2.07681793
78Abnormal biliary tract physiology (HP:0012439)2.07681793
79Arthralgia (HP:0002829)2.07657910
80Arterial thrombosis (HP:0004420)2.06712037
81Hemoptysis (HP:0002105)2.05379123
82Abnormality of oral frenula (HP:0000190)2.05277722
83Abnormality of the pleura (HP:0002103)2.03368696
84Dysostosis multiplex (HP:0000943)2.02805582
85Overriding aorta (HP:0002623)2.02092517
86Premature ovarian failure (HP:0008209)2.00194633
87Urinary glycosaminoglycan excretion (HP:0003541)1.97217177
88Mucopolysacchariduria (HP:0008155)1.97217177
89Keratoconjunctivitis sicca (HP:0001097)1.94892714
90Recurrent bronchitis (HP:0002837)1.93117864
91Increased IgE level (HP:0003212)1.92225567
92Hypoalbuminemia (HP:0003073)1.92003457
93Abnormal albumin level (HP:0012116)1.92003457
94Increased intramyocellular lipid droplets (HP:0012240)1.91057166
95Dislocated radial head (HP:0003083)1.90959899
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90567018
97Deformed sella turcica (HP:0002681)1.90504997
98Loss of speech (HP:0002371)1.87694920
99Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86904200
100Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86904200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK6.64070479
2TXK5.59071336
3MAP4K13.75097929
4BMPR23.47081163
5FES3.01192141
6TAOK32.56905576
7MAP3K42.55702982
8MAP3K142.24589943
9BTK2.22263145
10JAK32.10036693
11ITK2.09266326
12SIK31.97251180
13KDR1.90679969
14TNK21.86000626
15GRK71.82285097
16RIPK41.78112426
17IRAK41.69396557
18ZAP701.66218497
19GRK61.64800810
20LCK1.60550504
21JAK11.55656158
22MARK31.54890157
23IKBKE1.53394583
24TLK11.51856347
25CSK1.50673705
26HCK1.48575044
27TBK11.48491562
28STK101.46014779
29IKBKB1.44520828
30LYN1.32605758
31PRKCQ1.31638333
32TYK21.31023617
33SYK1.27752612
34ADRBK21.13943629
35TESK20.97716326
36NUAK10.89321696
37TGFBR20.88393947
38TEC0.88257082
39MAPKAPK30.86711441
40PINK10.84168702
41BLK0.83500108
42ZAK0.82443839
43CAMKK20.82382533
44JAK20.82138221
45MAPK110.80620431
46ERBB20.78008734
47MOS0.77387027
48EPHB10.76868896
49KIT0.76861000
50EIF2AK20.74262993
51CDK40.73291295
52STK390.70721969
53LRRK20.70509969
54GRK50.70039054
55CSF1R0.68760590
56EIF2AK30.67978934
57PTK60.66032512
58PIM10.65165082
59GRK10.59109429
60NTRK20.58095620
61MAPK130.58062486
62SIK20.56076771
63FGR0.55721001
64MAP2K20.55173693
65TAF10.53113355
66CDK60.52206144
67MST40.51701127
68NEK60.51426306
69WNK40.51377224
70MAP3K110.50080277
71PRKCH0.49140041
72ABL10.44162120
73IGF1R0.40765982
74CAMKK10.38319786
75INSR0.32734400
76ERBB30.31938378
77FYN0.31505574
78HIPK20.30886195
79MAPKAPK20.30744840
80BCKDK0.30559239
81MAP3K50.30195264
82TYRO30.29615032
83MATK0.29131418
84PDK10.28233953
85ADRBK10.27148513
86ILK0.26827029
87MAPK120.26521701
88CDK90.25645076
89PIK3CG0.24941012
90MAPK70.21840137
91MAP3K120.21634413
92CLK10.21183544
93NLK0.21095756
94DYRK1B0.20576235
95NME10.19638822
96EPHA30.19229020
97PRKCD0.15624704
98PRPF4B0.14986922
99TAOK20.14741103
100SRC0.14051610

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.54076171
2Primary immunodeficiency_Homo sapiens_hsa053404.79814458
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.09517921
4Allograft rejection_Homo sapiens_hsa053303.67244793
5Autoimmune thyroid disease_Homo sapiens_hsa053203.57122956
6Antigen processing and presentation_Homo sapiens_hsa046123.51055257
7Type I diabetes mellitus_Homo sapiens_hsa049402.75220671
8T cell receptor signaling pathway_Homo sapiens_hsa046602.56162637
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.33588637
10Hematopoietic cell lineage_Homo sapiens_hsa046402.27106357
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07514197
12Measles_Homo sapiens_hsa051622.06859830
13Asthma_Homo sapiens_hsa053101.94875557
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.91914201
15Viral myocarditis_Homo sapiens_hsa054161.77296675
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.72725741
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63502116
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62082200
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.57798123
20Chemokine signaling pathway_Homo sapiens_hsa040621.56488156
21Staphylococcus aureus infection_Homo sapiens_hsa051501.55713567
22Leishmaniasis_Homo sapiens_hsa051401.51543646
23B cell receptor signaling pathway_Homo sapiens_hsa046621.39417355
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35722284
25Malaria_Homo sapiens_hsa051441.35367480
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.33089788
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32121199
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25247851
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21534700
30Osteoclast differentiation_Homo sapiens_hsa043801.17913868
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12775132
32Herpes simplex infection_Homo sapiens_hsa051681.12439642
33Platelet activation_Homo sapiens_hsa046111.05968668
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02567641
35Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98900351
36Nitrogen metabolism_Homo sapiens_hsa009100.96740269
37Shigellosis_Homo sapiens_hsa051310.88615767
38Tuberculosis_Homo sapiens_hsa051520.84583881
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82095244
40Apoptosis_Homo sapiens_hsa042100.78215449
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77825915
42Rheumatoid arthritis_Homo sapiens_hsa053230.77725111
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77631481
44Influenza A_Homo sapiens_hsa051640.75056094
45Caffeine metabolism_Homo sapiens_hsa002320.74880064
46Regulation of autophagy_Homo sapiens_hsa041400.73927026
47Legionellosis_Homo sapiens_hsa051340.70624451
48TNF signaling pathway_Homo sapiens_hsa046680.69387655
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66235968
50African trypanosomiasis_Homo sapiens_hsa051430.64324518
51Toxoplasmosis_Homo sapiens_hsa051450.61588560
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61477439
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61302787
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60582776
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59057632
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.50546483
57Pertussis_Homo sapiens_hsa051330.50516511
58RNA degradation_Homo sapiens_hsa030180.50320277
59HTLV-I infection_Homo sapiens_hsa051660.49131204
60Acute myeloid leukemia_Homo sapiens_hsa052210.49050755
61Peroxisome_Homo sapiens_hsa041460.47886042
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45276284
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45160846
64Proteasome_Homo sapiens_hsa030500.44573552
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.43909090
66Lysosome_Homo sapiens_hsa041420.42738706
67Arachidonic acid metabolism_Homo sapiens_hsa005900.42721556
68Morphine addiction_Homo sapiens_hsa050320.40555156
69Epstein-Barr virus infection_Homo sapiens_hsa051690.38748656
70Endocytosis_Homo sapiens_hsa041440.37372276
71Other glycan degradation_Homo sapiens_hsa005110.34527523
72Hepatitis B_Homo sapiens_hsa051610.33349907
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32680972
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32360917
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31435900
76Linoleic acid metabolism_Homo sapiens_hsa005910.28778982
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.26909338
78Chemical carcinogenesis_Homo sapiens_hsa052040.26813286
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26167468
80Hepatitis C_Homo sapiens_hsa051600.25744947
81Viral carcinogenesis_Homo sapiens_hsa052030.24563871
82ABC transporters_Homo sapiens_hsa020100.24404365
83Non-small cell lung cancer_Homo sapiens_hsa052230.24208921
84One carbon pool by folate_Homo sapiens_hsa006700.22892136
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.22363321
86Salmonella infection_Homo sapiens_hsa051320.21900320
87Renin secretion_Homo sapiens_hsa049240.20854293
88Phagosome_Homo sapiens_hsa041450.19637484
89Glycerolipid metabolism_Homo sapiens_hsa005610.19445755
90N-Glycan biosynthesis_Homo sapiens_hsa005100.18225220
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17667027
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16723867
93Choline metabolism in cancer_Homo sapiens_hsa052310.16505832
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16024662
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14909045
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14524857
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13169353
98Insulin resistance_Homo sapiens_hsa049310.12880408
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.09754306
100cAMP signaling pathway_Homo sapiens_hsa040240.08848446

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