FTH1P23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)6.31355479
2cytidine deamination (GO:0009972)6.31355479
3cytidine metabolic process (GO:0046087)6.31355479
4DNA deamination (GO:0045006)6.03964256
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.42145413
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.26763964
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.12963084
8actin nucleation (GO:0045010)4.47167428
9immunoglobulin mediated immune response (GO:0016064)4.28253506
10positive regulation of B cell differentiation (GO:0045579)4.06165438
11regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.75655572
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.73830425
13negative regulation of T cell apoptotic process (GO:0070233)3.68287241
14positive regulation of monocyte chemotaxis (GO:0090026)3.63324776
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.57122314
16positive thymic T cell selection (GO:0045059)3.56243347
17B cell mediated immunity (GO:0019724)3.52968795
18regulation of B cell receptor signaling pathway (GO:0050855)3.52915252
19positive regulation of interleukin-8 secretion (GO:2000484)3.42672810
20sequestering of actin monomers (GO:0042989)3.41482005
21pyrimidine nucleoside catabolic process (GO:0046135)3.38422519
22positive regulation of gamma-delta T cell activation (GO:0046645)3.38251661
23regulation of activation of Janus kinase activity (GO:0010533)3.26379463
24regulation of chronic inflammatory response (GO:0002676)3.25150597
25positive T cell selection (GO:0043368)3.21106140
26response to interferon-beta (GO:0035456)3.20506448
27purine nucleotide salvage (GO:0032261)3.18097420
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17232827
29T cell costimulation (GO:0031295)3.17046740
30positive regulation of calcium-mediated signaling (GO:0050850)3.16917434
31T cell migration (GO:0072678)3.15002918
32eosinophil chemotaxis (GO:0048245)3.13894021
33lymphocyte costimulation (GO:0031294)3.13743952
34regulation of B cell differentiation (GO:0045577)3.11967076
35positive regulation of lymphocyte migration (GO:2000403)3.09764558
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06959715
37regulation of regulatory T cell differentiation (GO:0045589)3.03747966
38negative regulation of lymphocyte apoptotic process (GO:0070229)3.00202721
39negative regulation of viral genome replication (GO:0045071)2.99459517
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99235553
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99235553
42regulation of interleukin-8 secretion (GO:2000482)2.98126458
43platelet dense granule organization (GO:0060155)2.96929123
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96224948
45negative T cell selection (GO:0043383)2.96057893
46regulation of T cell tolerance induction (GO:0002664)2.94763806
47mature B cell differentiation involved in immune response (GO:0002313)2.91914609
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88628560
49energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87211219
50ATP synthesis coupled proton transport (GO:0015986)2.87211219
51purine deoxyribonucleotide catabolic process (GO:0009155)2.87066479
52eosinophil migration (GO:0072677)2.84229897
53positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.83581252
54positive regulation of T cell migration (GO:2000406)2.82737653
55negative regulation by host of viral transcription (GO:0043922)2.79397169
56positive regulation of alpha-beta T cell proliferation (GO:0046641)2.77279568
57granulocyte activation (GO:0036230)2.76448427
58regulation of antigen processing and presentation (GO:0002577)2.75386295
59neutrophil activation involved in immune response (GO:0002283)2.75044659
60deoxyribonucleotide catabolic process (GO:0009264)2.74148286
61respiratory electron transport chain (GO:0022904)2.73547461
62positive regulation of natural killer cell mediated immunity (GO:0002717)2.73254609
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71859015
64T cell receptor signaling pathway (GO:0050852)2.71531423
65positive regulation of T cell mediated cytotoxicity (GO:0001916)2.71275055
66regulation of T cell apoptotic process (GO:0070232)2.70450599
67macrophage chemotaxis (GO:0048246)2.70361257
68regulation of alpha-beta T cell proliferation (GO:0046640)2.70325965
69autophagic vacuole fusion (GO:0000046)2.69839508
70electron transport chain (GO:0022900)2.69590893
71mast cell activation (GO:0045576)2.69531745
72positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.67304470
73regulation of T cell receptor signaling pathway (GO:0050856)2.66949284
74positive regulation of defense response to virus by host (GO:0002230)2.66637664
75lymphocyte chemotaxis (GO:0048247)2.66338055
76deoxyribose phosphate catabolic process (GO:0046386)2.65940705
77iron-sulfur cluster assembly (GO:0016226)2.64874414
78metallo-sulfur cluster assembly (GO:0031163)2.64874414
79regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.64813556
80regulation of tolerance induction (GO:0002643)2.64601543
81neutrophil activation (GO:0042119)2.64048395
82positive regulation of tolerance induction (GO:0002645)2.63201618
83positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.63075199
84interferon-gamma-mediated signaling pathway (GO:0060333)2.62014010
85protein neddylation (GO:0045116)2.61623024
86positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.60344069
87positive regulation of antigen processing and presentation (GO:0002579)2.59595237
88regulation of T cell migration (GO:2000404)2.59088302
89antigen receptor-mediated signaling pathway (GO:0050851)2.58724554
90regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.58320470
91negative regulation of leukocyte apoptotic process (GO:2000107)2.57797482
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.56451748
93antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.55433930
94positive regulation of interleukin-17 production (GO:0032740)2.54512152
95regulation of lymphocyte chemotaxis (GO:1901623)2.54238942
96positive regulation of interleukin-1 beta secretion (GO:0050718)2.52401786
97regulation of natural killer cell mediated immunity (GO:0002715)2.51277538
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.51277538
99regulation of monocyte chemotaxis (GO:0090025)2.51058151
100purine-containing compound salvage (GO:0043101)2.49691846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.91634013
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.45130195
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.93586072
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.67406222
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28074521
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20666669
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.96321039
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76380949
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72020147
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51899107
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.50552311
12MYB_26560356_Chip-Seq_TH2_Human2.40453331
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34621269
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13930066
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10287899
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01435572
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00378675
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.96522050
19SCL_19346495_ChIP-Seq_HPC-7_Human1.91300004
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88966400
21RUNX_20019798_ChIP-Seq_JUKART_Human1.85780732
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80300143
23GATA3_27048872_Chip-Seq_THYMUS_Human1.78390437
24SPI1_23547873_ChIP-Seq_NB4_Human1.75664814
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74901095
26VDR_23849224_ChIP-Seq_CD4+_Human1.72524706
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69848774
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69417310
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68053090
30GATA3_26560356_Chip-Seq_TH2_Human1.67261222
31VDR_22108803_ChIP-Seq_LS180_Human1.63059187
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.61077286
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58230001
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56158139
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.53790920
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50846209
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.50092329
38MYB_26560356_Chip-Seq_TH1_Human1.46894558
39BCL6_27268052_Chip-Seq_Bcells_Human1.45525591
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.44185741
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39500355
42UTX_26944678_Chip-Seq_JUKART_Human1.34623869
43PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.33436073
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31709497
45ZNF274_21170338_ChIP-Seq_K562_Hela1.29254054
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.28446797
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24568967
48FOXP3_21729870_ChIP-Seq_TREG_Human1.24382307
49IGF1R_20145208_ChIP-Seq_DFB_Human1.22690017
50TP53_22573176_ChIP-Seq_HFKS_Human1.20675268
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19219569
52TAF2_19829295_ChIP-Seq_ESCs_Human1.16320336
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16085214
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.15934564
55AR_20517297_ChIP-Seq_VCAP_Human1.15596663
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15271890
57STAT1_20625510_ChIP-Seq_HELA_Human1.14710622
58NANOG_20526341_ChIP-Seq_ESCs_Human1.11817127
59P300_27268052_Chip-Seq_Bcells_Human1.11750466
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10265725
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07865217
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.07865217
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07020121
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06806142
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06600822
66EZH2_22144423_ChIP-Seq_EOC_Human1.06066193
67HTT_18923047_ChIP-ChIP_STHdh_Human1.05046835
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05016012
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.04468129
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04465287
71ERG_20517297_ChIP-Seq_VCAP_Human1.04270744
72MAF_26560356_Chip-Seq_TH2_Human1.02742789
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00669344
74MAF_26560356_Chip-Seq_TH1_Human0.98820276
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98275742
76NANOG_19829295_ChIP-Seq_ESCs_Human0.98261020
77SOX2_19829295_ChIP-Seq_ESCs_Human0.98261020
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98199897
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97970468
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97900012
81FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96668039
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96488984
83FLI1_27457419_Chip-Seq_LIVER_Mouse0.95613059
84GATA3_21878914_ChIP-Seq_MCF-7_Human0.92382066
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91132283
86BCOR_27268052_Chip-Seq_Bcells_Human0.90977924
87CTCF_20526341_ChIP-Seq_ESCs_Human0.90355148
88SPI1_23127762_ChIP-Seq_K562_Human0.88917520
89MYC_19829295_ChIP-Seq_ESCs_Human0.88833506
90SPI1_20517297_ChIP-Seq_HL60_Human0.88590659
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88173981
92CIITA_25753668_ChIP-Seq_RAJI_Human0.87075641
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86607419
94NCOR_22424771_ChIP-Seq_293T_Human0.86294669
95E2F1_20622854_ChIP-Seq_HELA_Human0.85260525
96STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84570797
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84101130
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83881962
99GATA3_26560356_Chip-Seq_TH1_Human0.82426375
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80526360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.77781196
2MP0001835_abnormal_antigen_presentation4.19989957
3MP0009785_altered_susceptibility_to3.53778520
4MP0002148_abnormal_hypersensitivity_rea3.15889791
5MP0005000_abnormal_immune_tolerance2.86051474
6MP0003806_abnormal_nucleotide_metabolis2.77115540
7MP0003724_increased_susceptibility_to2.65443055
8MP0001800_abnormal_humoral_immune2.50687079
9MP0005025_abnormal_response_to2.50669552
10MP0005464_abnormal_platelet_physiology2.43266179
11MP0002723_abnormal_immune_serum2.36316646
12MP0006082_CNS_inflammation2.34408998
13MP0009333_abnormal_splenocyte_physiolog2.26561165
14MP0002452_abnormal_antigen_presenting2.21392771
15MP0002420_abnormal_adaptive_immunity2.20070826
16MP0001819_abnormal_immune_cell2.17189145
17MP0005387_immune_system_phenotype2.15937935
18MP0001790_abnormal_immune_system2.15937935
19MP0003763_abnormal_thymus_physiology2.12836436
20MP0003436_decreased_susceptibility_to2.02916403
21MP0009764_decreased_sensitivity_to2.02874231
22MP0002419_abnormal_innate_immunity1.91939734
23MP0000372_irregular_coat_pigmentation1.78181408
24MP0000685_abnormal_immune_system1.76074343
25MP0002398_abnormal_bone_marrow1.72234223
26MP0005645_abnormal_hypothalamus_physiol1.70918282
27MP0000716_abnormal_immune_system1.68767101
28MP0001845_abnormal_inflammatory_respons1.64567367
29MP0000465_gastrointestinal_hemorrhage1.63354334
30MP0002405_respiratory_system_inflammati1.63019254
31MP0005075_abnormal_melanosome_morpholog1.61806501
32MP0010155_abnormal_intestine_physiology1.59638366
33MP0002166_altered_tumor_susceptibility1.58215637
34MP0001873_stomach_inflammation1.53960603
35MP0003866_abnormal_defecation1.50449078
36MP0000689_abnormal_spleen_morphology1.48074637
37MP0008469_abnormal_protein_level1.44104574
38MP0005084_abnormal_gallbladder_morpholo1.37783904
39MP0006072_abnormal_retinal_apoptosis1.35678159
40MP0002429_abnormal_blood_cell1.34792055
41MP0004147_increased_porphyrin_level1.34254681
42MP0002006_tumorigenesis1.32616919
43MP0002722_abnormal_immune_system1.31398638
44MP0005397_hematopoietic_system_phenotyp1.29124005
45MP0001545_abnormal_hematopoietic_system1.29124005
46MP0009379_abnormal_foot_pigmentation1.26221032
47MP0003075_altered_response_to1.25778870
48MP0002837_dystrophic_cardiac_calcinosis1.23988881
49MP0002138_abnormal_hepatobiliary_system1.23351839
50MP0003646_muscle_fatigue1.22650094
51MP0001905_abnormal_dopamine_level1.22051437
52MP0009763_increased_sensitivity_to1.21812410
53MP0008872_abnormal_physiological_respon1.19751590
54MP0009278_abnormal_bone_marrow1.18465552
55MP0001853_heart_inflammation1.18334210
56MP0008995_early_reproductive_senescence1.15989206
57MP0001533_abnormal_skeleton_physiology1.15480987
58MP0002102_abnormal_ear_morphology1.12993743
59MP0005646_abnormal_pituitary_gland1.11911903
60MP0006036_abnormal_mitochondrial_physio1.11731018
61MP0005410_abnormal_fertilization1.10555033
62MP0008875_abnormal_xenobiotic_pharmacok1.08424757
63MP0000343_altered_response_to1.07100825
64MP0001764_abnormal_homeostasis1.01168742
65MP0003195_calcinosis1.00946491
66MP0003186_abnormal_redox_activity1.00394084
67MP0002653_abnormal_ependyma_morphology0.98689400
68MP0002095_abnormal_skin_pigmentation0.97669360
69MP0003448_altered_tumor_morphology0.97593166
70MP0003303_peritoneal_inflammation0.96905326
71MP0004947_skin_inflammation0.96432674
72MP0005166_decreased_susceptibility_to0.96138053
73MP0005636_abnormal_mineral_homeostasis0.94636350
74MP0009765_abnormal_xenobiotic_induced0.92406389
75MP0002132_abnormal_respiratory_system0.91135811
76MP0002933_joint_inflammation0.90009088
77MP0005253_abnormal_eye_physiology0.87679260
78MP0000703_abnormal_thymus_morphology0.87314403
79MP0003011_delayed_dark_adaptation0.86283397
80MP0002277_abnormal_respiratory_mucosa0.84593503
81MP0008004_abnormal_stomach_pH0.83766695
82MP0001919_abnormal_reproductive_system0.81768083
83MP0009643_abnormal_urine_homeostasis0.80750406
84MP0001663_abnormal_digestive_system0.78975041
85MP0005551_abnormal_eye_electrophysiolog0.78940377
86MP0001968_abnormal_touch/_nociception0.78201956
87MP0009697_abnormal_copulation0.77511602
88MP0005360_urolithiasis0.76188287
89MP0002876_abnormal_thyroid_physiology0.75806690
90MP0000858_altered_metastatic_potential0.73570748
91MP0002139_abnormal_hepatobiliary_system0.72749434
92MP0002736_abnormal_nociception_after0.68796735
93MP0002693_abnormal_pancreas_physiology0.68629592
94MP0004142_abnormal_muscle_tone0.68286105
95MP0002019_abnormal_tumor_incidence0.67965192
96MP0003786_premature_aging0.67294575
97MP0001542_abnormal_bone_strength0.66779554
98MP0001765_abnormal_ion_homeostasis0.65799779
99MP0003638_abnormal_response/metabolism_0.64555176
100MP0010386_abnormal_urinary_bladder0.64476711

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.82093857
2Elevated erythrocyte sedimentation rate (HP:0003565)4.44327838
3T lymphocytopenia (HP:0005403)3.73101188
4IgG deficiency (HP:0004315)3.64822250
5Mitochondrial inheritance (HP:0001427)3.62781297
6Severe combined immunodeficiency (HP:0004430)3.60557110
7Abnormality of the prostate (HP:0008775)3.59821797
8Abnormality of B cell number (HP:0010975)3.58558163
9Abnormality of T cell number (HP:0011839)3.53303816
10B lymphocytopenia (HP:0010976)3.51389755
11Hypoproteinemia (HP:0003075)3.48103539
12Acute necrotizing encephalopathy (HP:0006965)3.41950045
13Stomatitis (HP:0010280)3.39006270
14Abnormal mitochondria in muscle tissue (HP:0008316)3.38912072
15Hepatocellular necrosis (HP:0001404)3.35437121
16Increased intramyocellular lipid droplets (HP:0012240)3.25666762
17Chronic obstructive pulmonary disease (HP:0006510)3.23493409
18Obstructive lung disease (HP:0006536)3.23493409
19Increased IgM level (HP:0003496)3.07918322
20Autoimmune hemolytic anemia (HP:0001890)3.04608194
21Agammaglobulinemia (HP:0004432)3.04360219
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02491086
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02491086
24Hepatic necrosis (HP:0002605)3.01395251
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.95602035
26Petechiae (HP:0000967)2.90983590
27Increased CSF lactate (HP:0002490)2.89183344
28Increased muscle lipid content (HP:0009058)2.88049578
29Combined immunodeficiency (HP:0005387)2.87165152
30Meningitis (HP:0001287)2.85254268
313-Methylglutaconic aciduria (HP:0003535)2.84761677
32Thyroiditis (HP:0100646)2.83523924
33Acute encephalopathy (HP:0006846)2.82704753
34Progressive macrocephaly (HP:0004481)2.79089151
35Abnormality of T cells (HP:0002843)2.78763709
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.77016767
37Renal Fanconi syndrome (HP:0001994)2.70777691
38Congenital stationary night blindness (HP:0007642)2.66085871
39Generalized aminoaciduria (HP:0002909)2.65767717
40Abnormality of macrophages (HP:0004311)2.59705397
41Panhypogammaglobulinemia (HP:0003139)2.58098831
42Myositis (HP:0100614)2.53489322
43Abolished electroretinogram (ERG) (HP:0000550)2.53090841
44Encephalitis (HP:0002383)2.52089419
45Recurrent fungal infections (HP:0002841)2.50068200
46Abnormality of eosinophils (HP:0001879)2.48111351
47Leukocytosis (HP:0001974)2.42302593
48Chronic diarrhea (HP:0002028)2.37886100
49Decreased central vision (HP:0007663)2.37039424
50Abnormal rod and cone electroretinograms (HP:0008323)2.36786913
51Vasculitis (HP:0002633)2.34632553
52Increased hepatocellular lipid droplets (HP:0006565)2.31323681
53Cerebral edema (HP:0002181)2.30487388
54Cerebral palsy (HP:0100021)2.28688314
55Epistaxis (HP:0000421)2.28408665
56Eosinophilia (HP:0001880)2.28242135
57Purpura (HP:0000979)2.23571023
58Lipid accumulation in hepatocytes (HP:0006561)2.23226385
59Exertional dyspnea (HP:0002875)2.22544070
60Autoimmune thrombocytopenia (HP:0001973)2.21078490
61Recurrent cutaneous fungal infections (HP:0011370)2.20242292
62Chronic mucocutaneous candidiasis (HP:0002728)2.20242292
63Gangrene (HP:0100758)2.19773023
64Recurrent viral infections (HP:0004429)2.19578211
65Mediastinal lymphadenopathy (HP:0100721)2.19354597
66Pulmonary infiltrates (HP:0002113)2.18989011
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18533031
68Recurrent bronchitis (HP:0002837)2.18101054
69Hemoptysis (HP:0002105)2.15540263
70Prolonged bleeding time (HP:0003010)2.14930821
71Optic disc pallor (HP:0000543)2.12209998
72Recurrent abscess formation (HP:0002722)2.11467060
73Hypergammaglobulinemia (HP:0010702)2.10399117
74Attenuation of retinal blood vessels (HP:0007843)2.09224766
75Chest pain (HP:0100749)2.08777395
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.08101228
77Granulocytopenia (HP:0001913)2.06101572
78Lactic acidosis (HP:0003128)2.03500793
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03075127
80Dicarboxylic aciduria (HP:0003215)2.03075127
81Reduced antithrombin III activity (HP:0001976)2.02970050
82Abnormality of male internal genitalia (HP:0000022)2.01486024
83Type I transferrin isoform profile (HP:0003642)2.01175297
84Abnormality of the heme biosynthetic pathway (HP:0010472)1.99085379
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97440820
86Joint swelling (HP:0001386)1.96012581
87Type 2 muscle fiber atrophy (HP:0003554)1.95870315
88Abnormality of glycolipid metabolism (HP:0010969)1.94817034
89Abnormality of liposaccharide metabolism (HP:0010968)1.94817034
90Abnormality of glycosphingolipid metabolism (HP:0004343)1.94817034
91Severe visual impairment (HP:0001141)1.94418386
92Pancytopenia (HP:0001876)1.93403681
93Retrobulbar optic neuritis (HP:0100654)1.91686321
94Optic neuritis (HP:0100653)1.91686321
95Gingival bleeding (HP:0000225)1.91551096
96Abnormality of the pleura (HP:0002103)1.90744100
97Increased serum lactate (HP:0002151)1.90595151
98Pulmonary fibrosis (HP:0002206)1.90317400
99Amyotrophic lateral sclerosis (HP:0007354)1.89600231
100Recurrent bacterial skin infections (HP:0005406)1.88609551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.64554148
2TESK24.57160395
3TXK4.35778420
4BCKDK3.18837336
5TAOK32.77948710
6MAP4K12.54802180
7SCYL22.34743382
8ADRBK22.13015523
9BMPR22.02171710
10MAP4K22.01872922
11MAP3K121.99641298
12VRK21.96298128
13SYK1.83113988
14KIT1.80311905
15ITK1.77800865
16TEC1.77324181
17ZAK1.76589033
18CDK191.76153158
19MAP3K111.74260997
20TESK11.73303833
21PIM21.65041983
22CSF1R1.64209913
23GRK61.58719020
24GRK11.52414467
25IKBKB1.52316776
26GRK71.50984577
27FES1.50859335
28IKBKE1.44598949
29TBK11.34434949
30LIMK11.29185923
31TLK11.29052800
32BTK1.26306265
33MST41.23183744
34FLT31.21029733
35MYLK1.20834127
36JAK31.17478000
37LYN1.15988413
38TNK21.15262431
39NME21.14167032
40LCK1.13440423
41DAPK11.11069614
42MATK1.10880271
43NUAK11.07513998
44RIPK41.05827443
45VRK11.02045256
46ZAP701.00815475
47CSK0.97779232
48PRKCQ0.92391842
49BLK0.88694798
50PIM10.83156609
51PIK3CG0.81662905
52PINK10.81601977
53MUSK0.79883058
54BMPR1B0.74497307
55RPS6KA50.70634665
56ABL20.68722896
57TAOK20.66709997
58MAP2K70.64284767
59DAPK30.63465354
60INSRR0.60926653
61DAPK20.58322147
62STK160.57911142
63TIE10.57422215
64PKN10.56392892
65ARAF0.55715094
66MAPKAPK30.53964260
67MAP3K50.51515832
68OXSR10.51326028
69RPS6KA40.50981949
70CSNK1G30.49688459
71TYK20.49327200
72ADRBK10.48321927
73IGF1R0.48272919
74FYN0.47837384
75HCK0.45526839
76PRKCA0.42838231
77PRKCD0.38672528
78OBSCN0.38660861
79ABL10.37511101
80MAP3K140.36807402
81GRK50.36544108
82PRKACA0.35277875
83CCNB10.32439220
84JAK20.32262699
85ROCK10.32072325
86MARK30.31914554
87ILK0.31829984
88DYRK20.31350225
89MAP2K60.30737199
90CSNK2A10.29757622
91PAK10.29482974
92FRK0.28882775
93IRAK40.28414647
94PRKCE0.26905484
95CDK80.26074451
96PRKG20.25938357
97ERBB30.25850834
98CSNK1G20.25470647
99CHUK0.25271201
100AURKA0.23023670

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.93339634
2Allograft rejection_Homo sapiens_hsa053303.90758398
3Primary immunodeficiency_Homo sapiens_hsa053403.88629408
4Asthma_Homo sapiens_hsa053103.79174968
5Autoimmune thyroid disease_Homo sapiens_hsa053203.77359686
6Type I diabetes mellitus_Homo sapiens_hsa049403.27722864
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.98117200
8Proteasome_Homo sapiens_hsa030502.97649081
9Antigen processing and presentation_Homo sapiens_hsa046122.89431788
10Oxidative phosphorylation_Homo sapiens_hsa001902.79988361
11Rheumatoid arthritis_Homo sapiens_hsa053232.63917399
12Hematopoietic cell lineage_Homo sapiens_hsa046402.36808647
13Parkinsons disease_Homo sapiens_hsa050122.24957522
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.18974327
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04211936
16Staphylococcus aureus infection_Homo sapiens_hsa051501.97218817
17Viral myocarditis_Homo sapiens_hsa054161.74581785
18Leishmaniasis_Homo sapiens_hsa051401.56082105
19Ribosome_Homo sapiens_hsa030101.49363974
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44828198
21Alzheimers disease_Homo sapiens_hsa050101.42456638
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34464974
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25939360
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18167272
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.15365282
26Huntingtons disease_Homo sapiens_hsa050161.13636481
27Phototransduction_Homo sapiens_hsa047441.12282332
28Protein export_Homo sapiens_hsa030601.10082672
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07885799
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07061586
31Salmonella infection_Homo sapiens_hsa051321.07001873
32Collecting duct acid secretion_Homo sapiens_hsa049661.04640537
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03814792
34Systemic lupus erythematosus_Homo sapiens_hsa053221.02011831
35Malaria_Homo sapiens_hsa051440.97475884
36T cell receptor signaling pathway_Homo sapiens_hsa046600.96902815
37RNA polymerase_Homo sapiens_hsa030200.95854585
38Cardiac muscle contraction_Homo sapiens_hsa042600.94944390
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92612439
40Herpes simplex infection_Homo sapiens_hsa051680.89698948
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87430275
42Tuberculosis_Homo sapiens_hsa051520.81288909
43Measles_Homo sapiens_hsa051620.76964036
44Shigellosis_Homo sapiens_hsa051310.74759569
45Olfactory transduction_Homo sapiens_hsa047400.74223453
46Arachidonic acid metabolism_Homo sapiens_hsa005900.73500919
47Linoleic acid metabolism_Homo sapiens_hsa005910.72847550
48Pertussis_Homo sapiens_hsa051330.71435618
49Legionellosis_Homo sapiens_hsa051340.70712703
50Peroxisome_Homo sapiens_hsa041460.70670854
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69087952
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68521776
53Phagosome_Homo sapiens_hsa041450.68421369
54Nitrogen metabolism_Homo sapiens_hsa009100.65198223
55Caffeine metabolism_Homo sapiens_hsa002320.63538970
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62983147
57Regulation of autophagy_Homo sapiens_hsa041400.61634905
58African trypanosomiasis_Homo sapiens_hsa051430.61536753
59Sulfur metabolism_Homo sapiens_hsa009200.61371112
60Homologous recombination_Homo sapiens_hsa034400.60382502
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60307027
62Chemical carcinogenesis_Homo sapiens_hsa052040.59583280
63Pyrimidine metabolism_Homo sapiens_hsa002400.58149298
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.56900783
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52600332
66Influenza A_Homo sapiens_hsa051640.52248212
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47859570
68Lysosome_Homo sapiens_hsa041420.47834350
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.47442590
70Osteoclast differentiation_Homo sapiens_hsa043800.46402924
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45488656
72Toxoplasmosis_Homo sapiens_hsa051450.45323593
73Tryptophan metabolism_Homo sapiens_hsa003800.44803411
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43486185
75One carbon pool by folate_Homo sapiens_hsa006700.42062874
76Platelet activation_Homo sapiens_hsa046110.42020175
77Purine metabolism_Homo sapiens_hsa002300.41910413
78Ether lipid metabolism_Homo sapiens_hsa005650.41438716
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39685567
80Chemokine signaling pathway_Homo sapiens_hsa040620.39549750
81Butanoate metabolism_Homo sapiens_hsa006500.39242860
82Retinol metabolism_Homo sapiens_hsa008300.38309524
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38243011
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38206751
85Glutathione metabolism_Homo sapiens_hsa004800.37227452
86Epstein-Barr virus infection_Homo sapiens_hsa051690.37223804
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.35979413
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.32980820
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.30740360
90Fanconi anemia pathway_Homo sapiens_hsa034600.29575775
91Metabolic pathways_Homo sapiens_hsa011000.29368786
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28054169
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.26364260
94Propanoate metabolism_Homo sapiens_hsa006400.26267433
95TNF signaling pathway_Homo sapiens_hsa046680.26082319
96RNA degradation_Homo sapiens_hsa030180.26002276
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23848573
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22728568
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19878323
100Base excision repair_Homo sapiens_hsa034100.18653594

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »