FTH1P25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)6.94179734
2nucleoside diphosphate catabolic process (GO:0009134)6.67725836
3lactate metabolic process (GO:0006089)6.32837246
4negative regulation of acute inflammatory response (GO:0002674)6.31741682
5response to pheromone (GO:0019236)5.88118212
6regulation of glucokinase activity (GO:0033131)5.84732833
7regulation of hexokinase activity (GO:1903299)5.84732833
8negative regulation of hormone metabolic process (GO:0032351)4.70340457
9negative regulation of hormone biosynthetic process (GO:0032353)4.51199901
10inositol phosphate catabolic process (GO:0071545)4.25459628
11polyol catabolic process (GO:0046174)4.07010910
12cullin deneddylation (GO:0010388)4.01335109
13protein deneddylation (GO:0000338)3.97890929
14lipid particle organization (GO:0034389)3.92203523
15DNA ligation (GO:0006266)3.79667935
16regulation of energy homeostasis (GO:2000505)3.73606812
17negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.71419327
18protein import into peroxisome matrix (GO:0016558)3.71213142
19inositol phosphate dephosphorylation (GO:0046855)3.67001485
20phosphorylated carbohydrate dephosphorylation (GO:0046838)3.67001485
21retinal rod cell development (GO:0046548)3.62515359
22positive regulation of protein autophosphorylation (GO:0031954)3.59747125
23ketone body metabolic process (GO:1902224)3.55987587
24regulation of type B pancreatic cell apoptotic process (GO:2000674)3.54653636
25artery smooth muscle contraction (GO:0014824)3.50302028
26coenzyme A metabolic process (GO:0015936)3.48658966
27negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.46993664
28spermatid development (GO:0007286)3.45508692
29tricarboxylic acid cycle (GO:0006099)3.44460303
30histamine secretion (GO:0001821)3.37994552
31replication fork processing (GO:0031297)3.35825104
32positive regulation of respiratory burst (GO:0060267)3.34006843
33negative regulation of interleukin-1 beta production (GO:0032691)3.32891336
34purine nucleobase biosynthetic process (GO:0009113)3.30375444
35myelin assembly (GO:0032288)3.28756163
36type B pancreatic cell development (GO:0003323)3.28113907
37single strand break repair (GO:0000012)3.26451878
38daunorubicin metabolic process (GO:0044597)3.24847953
39polyketide metabolic process (GO:0030638)3.24847953
40doxorubicin metabolic process (GO:0044598)3.24847953
41regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.24379758
42cellular ketone body metabolic process (GO:0046950)3.21928482
43intracellular pH reduction (GO:0051452)3.21144152
44cobalamin metabolic process (GO:0009235)3.15113205
45negative regulation of norepinephrine secretion (GO:0010700)3.10745820
46regulation of glucocorticoid metabolic process (GO:0031943)3.08012541
47establishment of integrated proviral latency (GO:0075713)3.04778975
48signal peptide processing (GO:0006465)3.03797382
49positive regulation of megakaryocyte differentiation (GO:0045654)3.03532320
50valine metabolic process (GO:0006573)3.00662458
51branched-chain amino acid catabolic process (GO:0009083)3.00199946
52lysine metabolic process (GO:0006553)2.99236002
53lysine catabolic process (GO:0006554)2.99236002
54water-soluble vitamin biosynthetic process (GO:0042364)2.97172797
55protein localization to peroxisome (GO:0072662)2.97093278
56protein targeting to peroxisome (GO:0006625)2.97093278
57establishment of protein localization to peroxisome (GO:0072663)2.97093278
58non-recombinational repair (GO:0000726)2.96822745
59double-strand break repair via nonhomologous end joining (GO:0006303)2.96822745
60phenylpropanoid metabolic process (GO:0009698)2.95293226
61positive regulation of hormone biosynthetic process (GO:0046886)2.94687623
62regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.93929338
63positive regulation of glycolytic process (GO:0045821)2.92779439
64tonic smooth muscle contraction (GO:0014820)2.92364972
65establishment of protein localization to mitochondrial membrane (GO:0090151)2.92137043
66proteasome assembly (GO:0043248)2.90580920
67regulation of glycolytic process (GO:0006110)2.85207243
68aminoglycoside antibiotic metabolic process (GO:0030647)2.85159399
69intracellular protein transmembrane import (GO:0044743)2.84981726
70regulation of growth hormone secretion (GO:0060123)2.84355582
71peroxisome organization (GO:0007031)2.83262276
72endocrine pancreas development (GO:0031018)2.78131308
73negative regulation of JUN kinase activity (GO:0043508)2.78038708
74mitochondrial DNA replication (GO:0006264)2.74803802
75establishment of viral latency (GO:0019043)2.71624717
76xenobiotic catabolic process (GO:0042178)2.70670181
77positive regulation of mitotic sister chromatid separation (GO:1901970)2.69509981
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.69509981
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.69509981
80regulation of superoxide anion generation (GO:0032928)2.67193663
81misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.63704693
82DNA damage response, detection of DNA damage (GO:0042769)2.62664858
83regulation of steroid hormone biosynthetic process (GO:0090030)2.62264223
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60490078
85positive regulation of macroautophagy (GO:0016239)2.59925375
86GPI anchor biosynthetic process (GO:0006506)2.57855619
87attachment of spindle microtubules to kinetochore (GO:0008608)2.57571539
88somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.56322523
89isotype switching (GO:0045190)2.56322523
90somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.56322523
91histamine transport (GO:0051608)2.56014008
92glutathione derivative metabolic process (GO:1901685)2.55615558
93glutathione derivative biosynthetic process (GO:1901687)2.55615558
94peroxisomal transport (GO:0043574)2.55306578
95pH reduction (GO:0045851)2.52031610
96negative regulation of protein oligomerization (GO:0032460)2.51553365
97negative regulation of neurological system process (GO:0031645)2.50103205
98acrosome assembly (GO:0001675)2.49730616
99regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49403592
100phasic smooth muscle contraction (GO:0014821)2.49070520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.54248566
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.35752883
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.79833787
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17312447
5E2F7_22180533_ChIP-Seq_HELA_Human2.99487715
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98944730
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48692664
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40968741
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40015496
10HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.19172471
11ZNF274_21170338_ChIP-Seq_K562_Hela2.18968119
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13954456
13GBX2_23144817_ChIP-Seq_PC3_Human2.13215447
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.11950909
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08368516
16EWS_26573619_Chip-Seq_HEK293_Human2.07094548
17P300_19829295_ChIP-Seq_ESCs_Human1.95397911
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.92540121
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.91841260
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86389487
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.84378759
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77930544
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76218356
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75462895
25TAF15_26573619_Chip-Seq_HEK293_Human1.72937277
26VDR_22108803_ChIP-Seq_LS180_Human1.72081488
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.70199226
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68182949
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65943335
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65656823
31SMAD4_21799915_ChIP-Seq_A2780_Human1.61392926
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59664096
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56312090
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51943710
35KLF5_20875108_ChIP-Seq_MESCs_Mouse1.49879650
36ELK1_19687146_ChIP-ChIP_HELA_Human1.48952983
37IRF1_19129219_ChIP-ChIP_H3396_Human1.48035112
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46351640
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.45322514
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.45063938
41FUS_26573619_Chip-Seq_HEK293_Human1.42784084
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41796577
43VDR_23849224_ChIP-Seq_CD4+_Human1.40754388
44CBP_20019798_ChIP-Seq_JUKART_Human1.40273098
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40273098
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34043535
47TFEB_21752829_ChIP-Seq_HELA_Human1.33709323
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33646567
49HTT_18923047_ChIP-ChIP_STHdh_Human1.27713600
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.26257384
51CDX2_22108803_ChIP-Seq_LS180_Human1.25113832
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24776612
53TCF4_22108803_ChIP-Seq_LS180_Human1.22607812
54TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22256981
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.20862974
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19765417
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.19623489
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18525444
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.16289170
60SOX2_19829295_ChIP-Seq_ESCs_Human1.15246389
61NANOG_19829295_ChIP-Seq_ESCs_Human1.15246389
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11286555
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.11277861
64MYC_18940864_ChIP-ChIP_HL60_Human1.11147534
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09907858
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09185915
67STAT3_23295773_ChIP-Seq_U87_Human1.09136006
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.09100830
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08981618
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07566646
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07309228
72AR_25329375_ChIP-Seq_VCAP_Human1.07241496
73ER_23166858_ChIP-Seq_MCF-7_Human1.06582481
74CBP_21632823_ChIP-Seq_H3396_Human1.06434411
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03998417
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02776669
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01669394
78FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01253683
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.00781228
80TCF4_23295773_ChIP-Seq_U87_Human0.99779079
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98549688
82P53_22387025_ChIP-Seq_ESCs_Mouse0.96350753
83TP53_18474530_ChIP-ChIP_U2OS_Human0.96042021
84NFYB_21822215_ChIP-Seq_K562_Human0.95839473
85DCP1A_22483619_ChIP-Seq_HELA_Human0.95834122
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95441613
87AR_20517297_ChIP-Seq_VCAP_Human0.93161671
88JUN_21703547_ChIP-Seq_K562_Human0.92818476
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92783076
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92759479
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.92721528
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.92630392
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92212006
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92068022
95RUNX2_22187159_ChIP-Seq_PCA_Human0.91515703
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90720143
97CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89770328
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89713559
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89425704
100P300_18555785_Chip-Seq_ESCs_Mouse0.89416088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.15107228
2MP0003136_yellow_coat_color3.76857210
3MP0002102_abnormal_ear_morphology3.62560658
4MP0005075_abnormal_melanosome_morpholog3.54649188
5MP0002638_abnormal_pupillary_reflex3.23315909
6MP0008057_abnormal_DNA_replication3.07429008
7MP0003195_calcinosis2.79116486
8MP0003787_abnormal_imprinting2.75199386
9MP0002822_catalepsy2.73661236
10MP0003122_maternal_imprinting2.72065689
11MP0008877_abnormal_DNA_methylation2.51606018
12MP0002938_white_spotting2.48023306
13MP0002909_abnormal_adrenal_gland2.45199022
14MP0003121_genomic_imprinting2.36227006
15MP0010094_abnormal_chromosome_stability2.26492711
16MP0008058_abnormal_DNA_repair2.20892450
17MP0000566_synostosis2.17050592
18MP0003283_abnormal_digestive_organ2.16950635
19MP0003941_abnormal_skin_development2.09439262
20MP0010386_abnormal_urinary_bladder1.94437954
21MP0002277_abnormal_respiratory_mucosa1.92541656
22MP0002693_abnormal_pancreas_physiology1.87990117
23MP0002090_abnormal_vision1.86639302
24MP0001666_abnormal_nutrient_absorption1.86128628
25MP0009697_abnormal_copulation1.83394942
26MP0005253_abnormal_eye_physiology1.77206469
27MP0010352_gastrointestinal_tract_polyps1.77138577
28MP0005257_abnormal_intraocular_pressure1.74332426
29MP0001984_abnormal_olfaction1.74248836
30MP0001756_abnormal_urination1.71469179
31MP0006072_abnormal_retinal_apoptosis1.62715372
32MP0003123_paternal_imprinting1.59161836
33MP0002751_abnormal_autonomic_nervous1.55595101
34MP0000015_abnormal_ear_pigmentation1.53773115
35MP0001727_abnormal_embryo_implantation1.53188742
36MP0001529_abnormal_vocalization1.53040760
37MP0003718_maternal_effect1.52604984
38MP0002837_dystrophic_cardiac_calcinosis1.49253643
39MP0005408_hypopigmentation1.46068964
40MP0010234_abnormal_vibrissa_follicle1.42668592
41MP0003868_abnormal_feces_composition1.37776392
42MP0006035_abnormal_mitochondrial_morpho1.33889603
43MP0001324_abnormal_eye_pigmentation1.28093199
44MP0005171_absent_coat_pigmentation1.27648026
45MP0002095_abnormal_skin_pigmentation1.27482839
46MP0009046_muscle_twitch1.26000564
47MP0005551_abnormal_eye_electrophysiolog1.20651747
48MP0000371_diluted_coat_color1.19725418
49MP0000516_abnormal_urinary_system1.18486534
50MP0005367_renal/urinary_system_phenotyp1.18486534
51MP0004924_abnormal_behavior1.17345866
52MP0005386_behavior/neurological_phenoty1.17345866
53MP0004147_increased_porphyrin_level1.15952584
54MP0006036_abnormal_mitochondrial_physio1.12478855
55MP0003693_abnormal_embryo_hatching1.10284237
56MP0001944_abnormal_pancreas_morphology1.10229113
57MP0009672_abnormal_birth_weight1.10009630
58MP0008789_abnormal_olfactory_epithelium1.08707706
59MP0005395_other_phenotype1.08499048
60MP0002078_abnormal_glucose_homeostasis1.07571066
61MP0002177_abnormal_outer_ear1.06229794
62MP0000427_abnormal_hair_cycle1.00848830
63MP0005220_abnormal_exocrine_pancreas0.99558562
64MP0005174_abnormal_tail_pigmentation0.99537888
65MP0002163_abnormal_gland_morphology0.98020365
66MP0000569_abnormal_digit_pigmentation0.97717095
67MP0009703_decreased_birth_body0.96508389
68MP0003011_delayed_dark_adaptation0.92117156
69MP0003646_muscle_fatigue0.85604738
70MP0002229_neurodegeneration0.84873406
71MP0004270_analgesia0.82994501
72MP0005645_abnormal_hypothalamus_physiol0.82595585
73MP0002168_other_aberrant_phenotype0.82131167
74MP0002160_abnormal_reproductive_system0.81687757
75MP0001919_abnormal_reproductive_system0.80971053
76MP0003045_fibrosis0.80526430
77MP0005332_abnormal_amino_acid0.79803920
78MP0005195_abnormal_posterior_eye0.78736084
79MP0006276_abnormal_autonomic_nervous0.78011211
80MP0001929_abnormal_gametogenesis0.76771257
81MP0001764_abnormal_homeostasis0.75376984
82MP0005535_abnormal_body_temperature0.75342492
83MP0003111_abnormal_nucleus_morphology0.75060548
84MP0004957_abnormal_blastocyst_morpholog0.73773522
85MP0005083_abnormal_biliary_tract0.73161897
86MP0008007_abnormal_cellular_replicative0.73085462
87MP0000538_abnormal_urinary_bladder0.72568737
88MP0002557_abnormal_social/conspecific_i0.69900056
89MP0002118_abnormal_lipid_homeostasis0.69805338
90MP0001119_abnormal_female_reproductive0.68545351
91MP0002928_abnormal_bile_duct0.67010422
92MP0000647_abnormal_sebaceous_gland0.65347921
93MP0002184_abnormal_innervation0.63403421
94MP0005391_vision/eye_phenotype0.63337464
95MP0002210_abnormal_sex_determination0.61610530
96MP0005636_abnormal_mineral_homeostasis0.61196675
97MP0005319_abnormal_enzyme/_coenzyme0.60528690
98MP0005646_abnormal_pituitary_gland0.59376403
99MP0005389_reproductive_system_phenotype0.59091724
100MP0001145_abnormal_male_reproductive0.58573081

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)6.32964018
2Hypoglycemic coma (HP:0001325)5.11571461
3Hypoglycemic seizures (HP:0002173)5.11327842
4Pancreatic islet-cell hyperplasia (HP:0004510)4.95971284
5Thyroiditis (HP:0100646)4.62950547
6Abnormality of endocrine pancreas physiology (HP:0012093)4.54066574
7Abnormality of the pancreatic islet cells (HP:0006476)4.54066574
8Large for gestational age (HP:0001520)4.46856466
9Ketoacidosis (HP:0001993)4.04312056
10Aplasia/Hypoplasia of the fovea (HP:0008060)3.68104921
11Hypoplasia of the fovea (HP:0007750)3.68104921
12Severe combined immunodeficiency (HP:0004430)3.58092753
13Tetraparesis (HP:0002273)3.56427185
14Insulin-resistant diabetes mellitus (HP:0000831)3.54573220
15Hyperglycemia (HP:0003074)3.54544485
16Prominent metopic ridge (HP:0005487)3.51644572
17Aplasia/hypoplasia of the uterus (HP:0008684)3.41349004
18Hypothermia (HP:0002045)3.34516455
19Lower limb hyperreflexia (HP:0002395)3.33100115
20Abnormality of the metopic suture (HP:0005556)3.24831329
21Abnormality of the fovea (HP:0000493)3.12408486
22White forelock (HP:0002211)3.10361472
23Symptomatic seizures (HP:0011145)3.10209042
24Patchy hypopigmentation of hair (HP:0011365)3.08827219
25Intestinal atresia (HP:0011100)3.07587162
26Type I diabetes mellitus (HP:0100651)2.97493204
27Aplasia/Hypoplasia of the macula (HP:0008059)2.93952576
28Combined immunodeficiency (HP:0005387)2.81078514
29EEG with generalized epileptiform discharges (HP:0011198)2.71102398
30Aplasia/Hypoplasia affecting the retina (HP:0008061)2.68062475
31Blue irides (HP:0000635)2.67971798
32Epileptiform EEG discharges (HP:0011182)2.67311943
33Hypoplasia of the uterus (HP:0000013)2.65480367
34Abnormality of the labia minora (HP:0012880)2.64187001
35Hypsarrhythmia (HP:0002521)2.51264007
36Abnormal sex determination (HP:0012244)2.46345995
37Sex reversal (HP:0012245)2.46345995
38Generalized aminoaciduria (HP:0002909)2.45484558
39Progressive macrocephaly (HP:0004481)2.45063299
40Hypobetalipoproteinemia (HP:0003563)2.42666525
41Ketosis (HP:0001946)2.38909590
42Acute necrotizing encephalopathy (HP:0006965)2.36294932
43Heterochromia iridis (HP:0001100)2.34398693
44Cutaneous melanoma (HP:0012056)2.33958802
45Methylmalonic acidemia (HP:0002912)2.32617043
46Abnormality of the antihelix (HP:0009738)2.29713398
47Steatorrhea (HP:0002570)2.21066104
48Hypoproteinemia (HP:0003075)2.20758306
49Abnormality of methionine metabolism (HP:0010901)2.20017649
50Postnatal microcephaly (HP:0005484)2.19579771
51Unilateral renal agenesis (HP:0000122)2.17816497
52Ependymoma (HP:0002888)2.16791095
53Hydroxyprolinuria (HP:0003080)2.15511296
54Abnormality of proline metabolism (HP:0010907)2.15511296
55Thyroid-stimulating hormone excess (HP:0002925)2.11867603
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09608718
57Acute encephalopathy (HP:0006846)2.06644722
58Decreased muscle mass (HP:0003199)2.02383343
59Hepatic necrosis (HP:0002605)2.00685249
60Renal cortical cysts (HP:0000803)1.98898209
61Neoplasm of the adrenal gland (HP:0100631)1.98774624
62Type I transferrin isoform profile (HP:0003642)1.98317742
63Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98251871
64Astrocytoma (HP:0009592)1.95513365
65Abnormality of the astrocytes (HP:0100707)1.95513365
66Methylmalonic aciduria (HP:0012120)1.90542915
67Abnormality of chromosome stability (HP:0003220)1.89295423
68Hypochromic microcytic anemia (HP:0004840)1.88507530
69Neuroendocrine neoplasm (HP:0100634)1.87802030
70Abnormal mitochondria in muscle tissue (HP:0008316)1.82934477
71Posterior subcapsular cataract (HP:0007787)1.82689467
72Abnormal pancreas size (HP:0012094)1.82391289
73Thyroid carcinoma (HP:0002890)1.81331520
74Glioma (HP:0009733)1.81089127
75Neoplasm of the adrenal cortex (HP:0100641)1.78387643
76Cerebral hypomyelination (HP:0006808)1.78207640
77Homocystinuria (HP:0002156)1.73965252
78Abnormality of homocysteine metabolism (HP:0010919)1.73965252
79Septate vagina (HP:0001153)1.73776961
80Abnormality of alanine metabolism (HP:0010916)1.73129962
81Hyperalaninemia (HP:0003348)1.73129962
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73129962
83Hypomagnesemia (HP:0002917)1.72780958
84Bundle branch block (HP:0011710)1.72310404
85Hamartoma of the eye (HP:0010568)1.71929166
86Intestinal polyposis (HP:0200008)1.71880788
87Abnormal drinking behavior (HP:0030082)1.71660875
88Polydipsia (HP:0001959)1.71660875
89Medial flaring of the eyebrow (HP:0010747)1.71515789
90Cortical visual impairment (HP:0100704)1.70210664
91Abnormality of midbrain morphology (HP:0002418)1.69421163
92Molar tooth sign on MRI (HP:0002419)1.69421163
93Chromsome breakage (HP:0040012)1.67625946
94Fat malabsorption (HP:0002630)1.65124326
95Abnormality of the vitamin B12 metabolism (HP:0004341)1.64169699
96Rectovaginal fistula (HP:0000143)1.62817350
97Rectal fistula (HP:0100590)1.62817350
98Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.59232517
99Intestinal polyp (HP:0005266)1.58379433
100Status epilepticus (HP:0002133)1.56929674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.89925602
2PDK24.16998520
3BUB13.97907844
4PASK2.87091832
5MKNK22.82056168
6WNK32.80649632
7BMPR1B2.78423798
8TSSK62.64690427
9WEE12.62001475
10TTK2.38854773
11FGFR22.29238511
12PLK32.20536125
13MKNK12.18185270
14ACVR1B2.07636370
15PLK41.89304325
16TNIK1.73484238
17MST41.72477558
18PINK11.59652592
19BCR1.58398640
20ZAK1.53801559
21EIF2AK31.53297431
22YES11.48944471
23TRIM281.48623530
24CSNK1G11.38923480
25PLK21.35804089
26RIPK41.29321077
27BCKDK1.19520195
28MAP3K121.18099485
29PRKCH1.10317284
30PKN11.08253619
31TESK11.08175270
32MST1R1.07703745
33PAK31.06293397
34GRK10.99755012
35CDK30.97587634
36PTK2B0.96319663
37LIMK10.94141923
38NLK0.93044194
39PRKCG0.86562887
40PRKAA20.84460285
41PLK10.84052372
42CAMK1D0.83036803
43ATM0.82611631
44PBK0.78073692
45NUAK10.77882578
46SIK30.70874630
47PRKAA10.70834011
48INSRR0.70047769
49CHEK20.69174848
50ATR0.68917472
51ERBB40.68605898
52MINK10.65089293
53BRSK20.63800139
54EIF2AK10.61942132
55STK38L0.60375882
56ADRBK20.60219886
57TAOK30.57824047
58ZAP700.56669123
59NEK60.56533301
60TGFBR10.55789207
61BRSK10.55652869
62FLT30.54780535
63RPS6KA40.54282703
64NTRK30.54143709
65MARK30.54135394
66EGFR0.53462119
67MAP4K20.52514185
68GSK3A0.48748980
69FER0.48068125
70CLK10.47193063
71ADRBK10.46332885
72FGR0.46157214
73NEK10.45993081
74MAP3K70.44667077
75CAMK1G0.43813089
76CAMK10.41724572
77STK30.39624412
78MET0.39127736
79HIPK20.37745806
80AURKB0.37622497
81CSNK1G20.37280309
82CSNK1A10.34903189
83AKT30.34882568
84PRKDC0.34773886
85TLK10.34744383
86BRAF0.34459076
87CAMK2D0.34448960
88VRK10.33021779
89LRRK20.32758695
90DYRK20.32728777
91PRKCE0.32347606
92PRKD20.32050710
93FGFR30.31327180
94CAMKK20.31302640
95SGK20.28226773
96PIK3CG0.25693370
97STK100.25529154
98MAP3K40.25187269
99DYRK30.23652710
100MUSK0.22922570

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.94162655
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.59945884
3Vitamin B6 metabolism_Homo sapiens_hsa007504.09587050
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.83891758
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67555458
6Proteasome_Homo sapiens_hsa030502.52803551
7Protein export_Homo sapiens_hsa030602.51455217
8Fatty acid elongation_Homo sapiens_hsa000622.47348985
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34285193
10Butanoate metabolism_Homo sapiens_hsa006502.32438214
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.24321856
12Glutathione metabolism_Homo sapiens_hsa004802.09415966
13Propanoate metabolism_Homo sapiens_hsa006402.05377874
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92165344
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.73109895
16Circadian rhythm_Homo sapiens_hsa047101.72155084
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67896449
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60508412
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59330823
20Pancreatic secretion_Homo sapiens_hsa049721.56387318
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54145725
22Peroxisome_Homo sapiens_hsa041461.48553787
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.47827539
24Homologous recombination_Homo sapiens_hsa034401.46821670
25Insulin secretion_Homo sapiens_hsa049111.37122795
26RNA degradation_Homo sapiens_hsa030181.32036360
27Regulation of autophagy_Homo sapiens_hsa041401.30675671
28Pyruvate metabolism_Homo sapiens_hsa006201.30418923
29Tryptophan metabolism_Homo sapiens_hsa003801.25599242
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24988416
31Fatty acid metabolism_Homo sapiens_hsa012121.24634001
32Cell cycle_Homo sapiens_hsa041101.23640748
33Nitrogen metabolism_Homo sapiens_hsa009101.17263093
34RNA transport_Homo sapiens_hsa030131.14938352
35Type II diabetes mellitus_Homo sapiens_hsa049301.08330038
36Fatty acid biosynthesis_Homo sapiens_hsa000611.05889116
37Pyrimidine metabolism_Homo sapiens_hsa002401.05657189
38RNA polymerase_Homo sapiens_hsa030201.01926248
39One carbon pool by folate_Homo sapiens_hsa006700.98444134
40Basal transcription factors_Homo sapiens_hsa030220.97469114
41Purine metabolism_Homo sapiens_hsa002300.96614394
42Mismatch repair_Homo sapiens_hsa034300.94808491
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92274673
44DNA replication_Homo sapiens_hsa030300.90535881
45Fatty acid degradation_Homo sapiens_hsa000710.88326236
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87581325
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86657556
48mTOR signaling pathway_Homo sapiens_hsa041500.83002357
49Base excision repair_Homo sapiens_hsa034100.82173641
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79037631
51Fat digestion and absorption_Homo sapiens_hsa049750.78836357
52Fanconi anemia pathway_Homo sapiens_hsa034600.78190905
53Protein digestion and absorption_Homo sapiens_hsa049740.77696818
54Oocyte meiosis_Homo sapiens_hsa041140.76580823
55Lysine degradation_Homo sapiens_hsa003100.76270369
56Phototransduction_Homo sapiens_hsa047440.74955597
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70948194
58Folate biosynthesis_Homo sapiens_hsa007900.70134575
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69393946
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66969024
61Metabolic pathways_Homo sapiens_hsa011000.66884693
62Chemical carcinogenesis_Homo sapiens_hsa052040.64958473
63Oxidative phosphorylation_Homo sapiens_hsa001900.62417709
64p53 signaling pathway_Homo sapiens_hsa041150.60056964
65Collecting duct acid secretion_Homo sapiens_hsa049660.59713889
66Carbon metabolism_Homo sapiens_hsa012000.57355278
67Fructose and mannose metabolism_Homo sapiens_hsa000510.51752471
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50893606
69Selenocompound metabolism_Homo sapiens_hsa004500.50837386
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47447217
71Glycerolipid metabolism_Homo sapiens_hsa005610.47398337
72mRNA surveillance pathway_Homo sapiens_hsa030150.47249444
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46645459
74Starch and sucrose metabolism_Homo sapiens_hsa005000.42819295
75TGF-beta signaling pathway_Homo sapiens_hsa043500.41359145
76FoxO signaling pathway_Homo sapiens_hsa040680.37980291
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.34974716
78ABC transporters_Homo sapiens_hsa020100.34576865
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.32586886
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32279722
81Arachidonic acid metabolism_Homo sapiens_hsa005900.32144119
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31299744
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29663283
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29191953
85beta-Alanine metabolism_Homo sapiens_hsa004100.28585635
86Hedgehog signaling pathway_Homo sapiens_hsa043400.28427684
87Retinol metabolism_Homo sapiens_hsa008300.27494955
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27129942
89AMPK signaling pathway_Homo sapiens_hsa041520.26822921
90Inositol phosphate metabolism_Homo sapiens_hsa005620.25790042
91Sphingolipid metabolism_Homo sapiens_hsa006000.24990857
92Parkinsons disease_Homo sapiens_hsa050120.24760380
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24490259
94Huntingtons disease_Homo sapiens_hsa050160.24394998
95Lysosome_Homo sapiens_hsa041420.24007378
96Synaptic vesicle cycle_Homo sapiens_hsa047210.23638638
97Ovarian steroidogenesis_Homo sapiens_hsa049130.23287572
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22622321
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21455024
100Nucleotide excision repair_Homo sapiens_hsa034200.21191293

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