FTH1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.48461750
2cytidine deamination (GO:0009972)5.97877559
3cytidine metabolic process (GO:0046087)5.97877559
4cytidine catabolic process (GO:0006216)5.97877559
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.37580907
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.31895511
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.20053477
8platelet dense granule organization (GO:0060155)4.05560397
9actin nucleation (GO:0045010)3.96842374
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.88634656
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79643270
12ATP synthesis coupled proton transport (GO:0015986)3.79643270
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65556547
14cellular response to interleukin-15 (GO:0071350)3.61110732
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51580062
16negative regulation of T cell apoptotic process (GO:0070233)3.50775991
17eosinophil chemotaxis (GO:0048245)3.47038787
18respiratory electron transport chain (GO:0022904)3.39122161
19positive regulation of T cell mediated cytotoxicity (GO:0001916)3.38670870
20electron transport chain (GO:0022900)3.38642650
21regulation of activation of Janus kinase activity (GO:0010533)3.35573565
22protein neddylation (GO:0045116)3.25693384
23positive regulation of interleukin-8 secretion (GO:2000484)3.25273452
24regulation of T cell mediated cytotoxicity (GO:0001914)3.21686535
25regulation of chronic inflammatory response (GO:0002676)3.21232019
26regulation of B cell receptor signaling pathway (GO:0050855)3.19085914
27regulation of interleukin-8 secretion (GO:2000482)3.18672601
28mast cell activation (GO:0045576)3.15930539
29eosinophil migration (GO:0072677)3.14348175
30regulation of regulatory T cell differentiation (GO:0045589)3.12300564
31immunoglobulin mediated immune response (GO:0016064)3.11857832
32sequestering of actin monomers (GO:0042989)3.11337875
33negative regulation of heart rate (GO:0010459)3.08449101
34pyrimidine nucleoside catabolic process (GO:0046135)3.04588999
35protein complex biogenesis (GO:0070271)3.01940337
36positive regulation of calcium-mediated signaling (GO:0050850)3.01362829
37negative regulation by host of viral transcription (GO:0043922)2.98914475
38positive thymic T cell selection (GO:0045059)2.98291713
39positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.93022805
40regulation of T cell tolerance induction (GO:0002664)2.92835244
41positive regulation of monocyte chemotaxis (GO:0090026)2.89121099
42T cell costimulation (GO:0031295)2.88851775
43lymphocyte costimulation (GO:0031294)2.86083168
44positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.85358847
45positive regulation of defense response to virus by host (GO:0002230)2.85251223
46negative regulation of mast cell activation (GO:0033004)2.84899630
47positive T cell selection (GO:0043368)2.82939114
48T cell receptor signaling pathway (GO:0050852)2.81815146
49regulation of leukocyte mediated cytotoxicity (GO:0001910)2.80871233
50behavioral response to nicotine (GO:0035095)2.80305112
51antigen processing and presentation via MHC class Ib (GO:0002475)2.79394352
52negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.78916372
53granulocyte activation (GO:0036230)2.70280676
54hydrogen ion transmembrane transport (GO:1902600)2.70119798
55proton transport (GO:0015992)2.68678209
56neutrophil activation (GO:0042119)2.67683271
57indole-containing compound catabolic process (GO:0042436)2.66499884
58indolalkylamine catabolic process (GO:0046218)2.66499884
59tryptophan catabolic process (GO:0006569)2.66499884
60positive regulation of cell killing (GO:0031343)2.66066231
61regulation of T cell receptor signaling pathway (GO:0050856)2.65817834
62hydrogen transport (GO:0006818)2.63693091
63regulation of T cell apoptotic process (GO:0070232)2.62310479
64response to pheromone (GO:0019236)2.62174103
65respiratory chain complex IV assembly (GO:0008535)2.61236148
66negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.60433405
67amine catabolic process (GO:0009310)2.60331336
68cellular biogenic amine catabolic process (GO:0042402)2.60331336
69negative regulation of lymphocyte apoptotic process (GO:0070229)2.59558699
70regulation of cell killing (GO:0031341)2.59527564
71positive regulation of interleukin-1 beta secretion (GO:0050718)2.58499563
72T cell migration (GO:0072678)2.57703709
73macrophage chemotaxis (GO:0048246)2.57627271
74cytochrome complex assembly (GO:0017004)2.57609146
75positive regulation of tolerance induction (GO:0002645)2.56806248
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.56648161
77regulation of tolerance induction (GO:0002643)2.56508994
78response to interleukin-15 (GO:0070672)2.56220839
79negative regulation of calcium ion transport into cytosol (GO:0010523)2.54186703
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.53302866
81mitochondrial respiratory chain complex assembly (GO:0033108)2.51852951
82metallo-sulfur cluster assembly (GO:0031163)2.51592945
83iron-sulfur cluster assembly (GO:0016226)2.51592945
84kynurenine metabolic process (GO:0070189)2.50751136
85detection of light stimulus involved in sensory perception (GO:0050962)2.49850324
86detection of light stimulus involved in visual perception (GO:0050908)2.49850324
87positive regulation of lymphocyte migration (GO:2000403)2.48559687
88antigen receptor-mediated signaling pathway (GO:0050851)2.48337481
89regulation of cellular amino acid metabolic process (GO:0006521)2.48216124
90regulation of interleukin-1 beta secretion (GO:0050706)2.47162838
91negative regulation of viral genome replication (GO:0045071)2.46752262
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.45293682
93mitochondrial respiratory chain complex I assembly (GO:0032981)2.45293682
94NADH dehydrogenase complex assembly (GO:0010257)2.45293682
95positive regulation of interleukin-17 production (GO:0032740)2.44690746
96regulation of calcium-mediated signaling (GO:0050848)2.44658895
97regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.44628959
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.43595458
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.43595458
100GPI anchor metabolic process (GO:0006505)2.43219202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.29370846
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.84302262
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.81041005
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82279496
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72975886
6VDR_22108803_ChIP-Seq_LS180_Human2.68424928
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.63112236
8EZH2_22144423_ChIP-Seq_EOC_Human2.48281106
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37863539
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30887073
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28217147
12IGF1R_20145208_ChIP-Seq_DFB_Human2.27476642
13ZNF274_21170338_ChIP-Seq_K562_Hela2.24512696
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.20065822
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17412557
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.93407517
17ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92243659
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.88632435
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84635874
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80082592
21GATA3_26560356_Chip-Seq_TH2_Human1.80028550
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.69580416
23VDR_23849224_ChIP-Seq_CD4+_Human1.67139205
24MYB_26560356_Chip-Seq_TH2_Human1.65775824
25RUNX_20019798_ChIP-Seq_JUKART_Human1.62762052
26TP53_22573176_ChIP-Seq_HFKS_Human1.57431470
27TAF15_26573619_Chip-Seq_HEK293_Human1.53807581
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50740160
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46290726
30PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.44342102
31AR_20517297_ChIP-Seq_VCAP_Human1.43959723
32FOXA1_25329375_ChIP-Seq_VCAP_Human1.42992036
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42992036
34GATA3_27048872_Chip-Seq_THYMUS_Human1.42441864
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41755326
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37941272
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35706692
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35379915
39ER_23166858_ChIP-Seq_MCF-7_Human1.34745355
40SOX2_19829295_ChIP-Seq_ESCs_Human1.30891086
41NANOG_19829295_ChIP-Seq_ESCs_Human1.30891086
42TAF2_19829295_ChIP-Seq_ESCs_Human1.29998359
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29974891
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29942129
45IRF1_19129219_ChIP-ChIP_H3396_Human1.27253766
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25119479
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23686504
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.22698629
49P300_19829295_ChIP-Seq_ESCs_Human1.22575380
50MYC_18940864_ChIP-ChIP_HL60_Human1.22253316
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21918790
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19627126
53TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19180994
54BCAT_22108803_ChIP-Seq_LS180_Human1.18773947
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18570782
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17972730
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17348156
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15880042
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15821078
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.15525143
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15174320
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14930714
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14464881
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14308355
65HTT_18923047_ChIP-ChIP_STHdh_Human1.14244890
66NCOR_22424771_ChIP-Seq_293T_Human1.13691560
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12065203
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.11853003
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11262559
70ERG_20517297_ChIP-Seq_VCAP_Human1.11259142
71NANOG_20526341_ChIP-Seq_ESCs_Human1.10590534
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09679376
73GBX2_23144817_ChIP-Seq_PC3_Human1.09123950
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.08587739
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08159083
76CBP_20019798_ChIP-Seq_JUKART_Human1.07578351
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07578351
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07363699
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06786739
80GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.04750627
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04446084
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04403849
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04238390
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.03737287
85EWS_26573619_Chip-Seq_HEK293_Human1.03643084
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02523062
87MYC_19829295_ChIP-Seq_ESCs_Human1.02320728
88ELK1_19687146_ChIP-ChIP_HELA_Human1.01023759
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.00612311
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00504017
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00374640
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.99070363
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98210454
94ETS1_20019798_ChIP-Seq_JURKAT_Human0.94058852
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94048646
96MYB_26560356_Chip-Seq_TH1_Human0.93906204
97IRF8_27001747_Chip-Seq_BMDM_Mouse0.93891360
98HOXB7_26014856_ChIP-Seq_BT474_Human0.92982499
99BCL6_27268052_Chip-Seq_Bcells_Human0.92628773
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.92132967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.82940422
2MP0001835_abnormal_antigen_presentation3.37821688
3MP0009785_altered_susceptibility_to2.85433735
4MP0003724_increased_susceptibility_to2.39794102
5MP0002148_abnormal_hypersensitivity_rea2.39633043
6MP0005000_abnormal_immune_tolerance2.35185611
7MP0000372_irregular_coat_pigmentation2.20576768
8MP0001800_abnormal_humoral_immune2.18913511
9MP0003646_muscle_fatigue2.12341011
10MP0006072_abnormal_retinal_apoptosis1.99339302
11MP0002723_abnormal_immune_serum1.98108764
12MP0003806_abnormal_nucleotide_metabolis1.97676271
13MP0000685_abnormal_immune_system1.86947174
14MP0009764_decreased_sensitivity_to1.85480026
15MP0002420_abnormal_adaptive_immunity1.77350425
16MP0003866_abnormal_defecation1.76658107
17MP0005025_abnormal_response_to1.76053460
18MP0001819_abnormal_immune_cell1.75677400
19MP0002452_abnormal_antigen_presenting1.72761080
20MP0005645_abnormal_hypothalamus_physiol1.72668782
21MP0002102_abnormal_ear_morphology1.70417673
22MP0008872_abnormal_physiological_respon1.69658418
23MP0005646_abnormal_pituitary_gland1.65786853
24MP0006082_CNS_inflammation1.64893964
25MP0009333_abnormal_splenocyte_physiolog1.62974888
26MP0010155_abnormal_intestine_physiology1.62728654
27MP0005387_immune_system_phenotype1.61883522
28MP0001790_abnormal_immune_system1.61883522
29MP0002876_abnormal_thyroid_physiology1.60640305
30MP0005551_abnormal_eye_electrophysiolog1.60636737
31MP0002138_abnormal_hepatobiliary_system1.59689960
32MP0005075_abnormal_melanosome_morpholog1.54569935
33MP0003436_decreased_susceptibility_to1.52765275
34MP0003763_abnormal_thymus_physiology1.51963476
35MP0004147_increased_porphyrin_level1.50485843
36MP0005084_abnormal_gallbladder_morpholo1.48278343
37MP0006276_abnormal_autonomic_nervous1.48081756
38MP0003195_calcinosis1.47031810
39MP0005464_abnormal_platelet_physiology1.44679078
40MP0003011_delayed_dark_adaptation1.39826544
41MP0001845_abnormal_inflammatory_respons1.38851047
42MP0008877_abnormal_DNA_methylation1.37076266
43MP0005253_abnormal_eye_physiology1.30742317
44MP0001873_stomach_inflammation1.30694312
45MP0003878_abnormal_ear_physiology1.30172455
46MP0005377_hearing/vestibular/ear_phenot1.30172455
47MP0001905_abnormal_dopamine_level1.29589940
48MP0002419_abnormal_innate_immunity1.28613754
49MP0002166_altered_tumor_susceptibility1.28085227
50MP0000716_abnormal_immune_system1.25085593
51MP0002837_dystrophic_cardiac_calcinosis1.23928121
52MP0001968_abnormal_touch/_nociception1.23813293
53MP0008995_early_reproductive_senescence1.23797603
54MP0003787_abnormal_imprinting1.21027212
55MP0001501_abnormal_sleep_pattern1.21013440
56MP0004145_abnormal_muscle_electrophysio1.19752698
57MP0000569_abnormal_digit_pigmentation1.18405107
58MP0002398_abnormal_bone_marrow1.17430612
59MP0002736_abnormal_nociception_after1.16472148
60MP0002405_respiratory_system_inflammati1.15699875
61MP0009379_abnormal_foot_pigmentation1.14299366
62MP0004142_abnormal_muscle_tone1.13485567
63MP0002277_abnormal_respiratory_mucosa1.12779140
64MP0005410_abnormal_fertilization1.08946006
65MP0002095_abnormal_skin_pigmentation1.08734108
66MP0001984_abnormal_olfaction1.06705192
67MP0002638_abnormal_pupillary_reflex1.06578085
68MP0001986_abnormal_taste_sensitivity1.05772606
69MP0001919_abnormal_reproductive_system1.04474985
70MP0000689_abnormal_spleen_morphology1.02032681
71MP0008875_abnormal_xenobiotic_pharmacok0.98950805
72MP0005083_abnormal_biliary_tract0.98412580
73MP0002006_tumorigenesis0.97676449
74MP0001970_abnormal_pain_threshold0.97419601
75MP0002272_abnormal_nervous_system0.97397801
76MP0008469_abnormal_protein_level0.96146980
77MP0009745_abnormal_behavioral_response0.94742146
78MP0001765_abnormal_ion_homeostasis0.94522242
79MP0005636_abnormal_mineral_homeostasis0.94264126
80MP0003786_premature_aging0.93572300
81MP0001529_abnormal_vocalization0.91697262
82MP0006036_abnormal_mitochondrial_physio0.91555366
83MP0002429_abnormal_blood_cell0.90767491
84MP0003880_abnormal_central_pattern0.90457193
85MP0003252_abnormal_bile_duct0.90322824
86MP0002933_joint_inflammation0.88498166
87MP0004885_abnormal_endolymph0.88029403
88MP0005389_reproductive_system_phenotype0.87587045
89MP0003186_abnormal_redox_activity0.84959636
90MP0000230_abnormal_systemic_arterial0.84363277
91MP0009046_muscle_twitch0.83353550
92MP0002733_abnormal_thermal_nociception0.82941784
93MP0002722_abnormal_immune_system0.82346135
94MP0001533_abnormal_skeleton_physiology0.79996983
95MP0005085_abnormal_gallbladder_physiolo0.79790541
96MP0009763_increased_sensitivity_to0.79205661
97MP0003075_altered_response_to0.77649366
98MP0002693_abnormal_pancreas_physiology0.77569682
99MP0003638_abnormal_response/metabolism_0.77410670
100MP0001485_abnormal_pinna_reflex0.77385803

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.01407869
2Acute necrotizing encephalopathy (HP:0006965)3.95221911
3IgG deficiency (HP:0004315)3.90820656
4Elevated erythrocyte sedimentation rate (HP:0003565)3.86751824
5Hepatocellular necrosis (HP:0001404)3.60837792
6T lymphocytopenia (HP:0005403)3.59227850
7Hypoproteinemia (HP:0003075)3.58515567
8Abnormal mitochondria in muscle tissue (HP:0008316)3.58167019
9Congenital stationary night blindness (HP:0007642)3.53149268
10Increased CSF lactate (HP:0002490)3.48403883
11Abnormality of T cell number (HP:0011839)3.44397730
12Severe combined immunodeficiency (HP:0004430)3.32070951
13Progressive macrocephaly (HP:0004481)3.26955302
14Increased intramyocellular lipid droplets (HP:0012240)3.21511940
15Hepatic necrosis (HP:0002605)3.17358760
163-Methylglutaconic aciduria (HP:0003535)3.14112569
17Acute encephalopathy (HP:0006846)3.13064581
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.12181093
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.12181093
20Abnormality of the prostate (HP:0008775)3.11975945
21Increased hepatocellular lipid droplets (HP:0006565)3.11350151
22Pancreatic cysts (HP:0001737)2.93071051
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.92363889
24Lipid accumulation in hepatocytes (HP:0006561)2.91346041
25Aplastic anemia (HP:0001915)2.87932330
26Abnormality of midbrain morphology (HP:0002418)2.84859349
27Molar tooth sign on MRI (HP:0002419)2.84859349
28Abolished electroretinogram (ERG) (HP:0000550)2.83433775
29Renal Fanconi syndrome (HP:0001994)2.81678071
30Stomatitis (HP:0010280)2.77777389
31Thyroiditis (HP:0100646)2.71321276
32Congenital, generalized hypertrichosis (HP:0004540)2.70983028
33Increased muscle lipid content (HP:0009058)2.69597427
34Cerebral edema (HP:0002181)2.69095801
35Abnormal rod and cone electroretinograms (HP:0008323)2.59405751
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.55701064
37Increased IgM level (HP:0003496)2.54842243
38Exertional dyspnea (HP:0002875)2.52380811
39True hermaphroditism (HP:0010459)2.49258521
40Decreased central vision (HP:0007663)2.45320477
41Combined immunodeficiency (HP:0005387)2.43954793
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42477461
43Abnormality of eosinophils (HP:0001879)2.41146752
44Pancreatic fibrosis (HP:0100732)2.40787351
45Chronic diarrhea (HP:0002028)2.40114813
46Abnormality of T cells (HP:0002843)2.39017315
47Optic disc pallor (HP:0000543)2.37092655
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34562869
49Abnormality of B cell number (HP:0010975)2.32546331
50Attenuation of retinal blood vessels (HP:0007843)2.31039511
51Lactic acidosis (HP:0003128)2.21990606
52Type II lissencephaly (HP:0007260)2.21120536
53Increased serum lactate (HP:0002151)2.20717953
54Retinal dysplasia (HP:0007973)2.20655718
55Optic neuritis (HP:0100653)2.19800540
56Retrobulbar optic neuritis (HP:0100654)2.19800540
57Medial flaring of the eyebrow (HP:0010747)2.14678058
58Myositis (HP:0100614)2.11754627
59Abnormality of renal resorption (HP:0011038)2.11643212
60Hypoalbuminemia (HP:0003073)2.08154818
61Abnormal albumin level (HP:0012116)2.08154818
62Gangrene (HP:0100758)2.05200620
63Pulmonary infiltrates (HP:0002113)2.03639034
64B lymphocytopenia (HP:0010976)2.01310309
65Hemoptysis (HP:0002105)2.00812046
66Leukocytosis (HP:0001974)1.97580585
67Methylmalonic acidemia (HP:0002912)1.96010075
68Abnormality of the renal cortex (HP:0011035)1.94348359
69Vasculitis (HP:0002633)1.93713068
70Hypothermia (HP:0002045)1.92398702
71Obstructive lung disease (HP:0006536)1.91427653
72Chronic obstructive pulmonary disease (HP:0006510)1.91427653
73Prostate neoplasm (HP:0100787)1.90534823
74Agitation (HP:0000713)1.89769513
75Abnormality of the pleura (HP:0002103)1.86387103
76Respiratory failure (HP:0002878)1.86356632
77Pulmonary fibrosis (HP:0002206)1.84582808
78Abnormality of male internal genitalia (HP:0000022)1.81665612
79Hypomagnesemia (HP:0002917)1.81409614
80Encephalitis (HP:0002383)1.80872908
81Autoimmune hemolytic anemia (HP:0001890)1.80503188
82Recurrent bronchitis (HP:0002837)1.79958534
83Alveolar cell carcinoma (HP:0006519)1.78929821
84Orchitis (HP:0100796)1.78742977
85Abnormality of urine glucose concentration (HP:0011016)1.78056515
86Glycosuria (HP:0003076)1.78056515
87Eosinophilia (HP:0001880)1.77808935
88Petechiae (HP:0000967)1.77745502
89Methylmalonic aciduria (HP:0012120)1.77268561
90Renal cortical cysts (HP:0000803)1.76229954
91Chronic mucocutaneous candidiasis (HP:0002728)1.75844392
92Recurrent cutaneous fungal infections (HP:0011370)1.75844392
93Lethargy (HP:0001254)1.75783294
94Pancreatitis (HP:0001733)1.74758696
95Gastrointestinal infarctions (HP:0005244)1.74602737
96Type I transferrin isoform profile (HP:0003642)1.74392444
97Chronic sinusitis (HP:0011109)1.71849248
98Exercise intolerance (HP:0003546)1.69683416
99Abnormal drinking behavior (HP:0030082)1.69651277
100Polydipsia (HP:0001959)1.69651277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.44087204
2KDR3.48746266
3TESK23.25724389
4BCKDK3.12690364
5MAP3K123.07166542
6TAOK32.91900802
7TLK12.68437160
8GRK12.32558228
9CDK192.24750417
10MAP4K22.22630870
11BMPR22.22527481
12ADRBK22.20324951
13ZAK2.12171599
14GRK61.92593388
15MAP4K11.79023056
16MYLK1.75594039
17ITK1.71205373
18PINK11.68415376
19FRK1.66256510
20TRIM281.59244213
21TEC1.53127057
22MAPKAPK31.43164158
23WNK41.41646678
24SYK1.40076804
25IKBKB1.36269242
26MST41.35816765
27FES1.32221354
28NUAK11.31643053
29SCYL21.24258483
30LIMK11.22258055
31TIE11.19774093
32ERBB31.16860554
33BTK1.11555747
34OXSR11.09704464
35STK161.08429283
36GRK71.06892655
37WNK31.03633684
38LYN1.00717544
39IKBKE1.00028311
40INSRR0.99094623
41PRKCQ0.96533191
42CSF1R0.94672314
43MUSK0.93264007
44DAPK10.92829255
45LCK0.91840799
46MAPK130.89996837
47TESK10.88461383
48TNK20.88430212
49MATK0.85966239
50MAP2K70.80875827
51PIM20.78878236
52KIT0.77696604
53DAPK20.77226860
54ADRBK10.71467752
55TRPM70.67479835
56RPS6KA50.65877229
57STK390.65198447
58MAP3K40.64586970
59PIK3CG0.62992058
60CSK0.62428157
61TBK10.60596299
62ZAP700.60394331
63MAP3K110.59020462
64IGF1R0.56628877
65CSNK1G30.55910703
66MAP2K60.55866310
67DAPK30.54771933
68RPS6KA40.54076551
69BCR0.52998322
70DYRK20.51532352
71PRKCE0.51243879
72PIM10.50623667
73CAMKK20.48664765
74PIK3CA0.48649429
75JAK30.48272563
76PRKACA0.47868857
77PRKCA0.47480225
78PAK30.47375130
79ABL10.47244799
80ACVR1B0.47090104
81RIPK40.46770431
82ILK0.44677980
83HCK0.44545143
84OBSCN0.43115525
85PHKG10.42147011
86PHKG20.42147011
87CSNK1G20.42140233
88GRK50.41331390
89VRK20.39740396
90SIK30.39104857
91MAP3K140.38167918
92ROCK10.36675026
93ABL20.35955387
94CSNK1A1L0.35785072
95MINK10.35644179
96FYN0.35384411
97MAP2K20.35275078
98PTK2B0.35199248
99CAMK2A0.35153187
100EGFR0.34550059

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.67945964
2Asthma_Homo sapiens_hsa053103.60569486
3Allograft rejection_Homo sapiens_hsa053303.49072976
4Autoimmune thyroid disease_Homo sapiens_hsa053203.43455437
5Oxidative phosphorylation_Homo sapiens_hsa001903.41111582
6Proteasome_Homo sapiens_hsa030503.01765457
7Type I diabetes mellitus_Homo sapiens_hsa049403.00998012
8Primary immunodeficiency_Homo sapiens_hsa053402.98297382
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.89249827
10Parkinsons disease_Homo sapiens_hsa050122.68577246
11Antigen processing and presentation_Homo sapiens_hsa046122.51026896
12Rheumatoid arthritis_Homo sapiens_hsa053232.36164864
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08299678
14Protein export_Homo sapiens_hsa030602.03261749
15Phototransduction_Homo sapiens_hsa047441.92044553
16Hematopoietic cell lineage_Homo sapiens_hsa046401.90616804
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90256232
18Alzheimers disease_Homo sapiens_hsa050101.76316476
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.75138498
20Cardiac muscle contraction_Homo sapiens_hsa042601.58615435
21Ribosome_Homo sapiens_hsa030101.58167616
22Viral myocarditis_Homo sapiens_hsa054161.55901684
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53443158
24Huntingtons disease_Homo sapiens_hsa050161.50954268
25Staphylococcus aureus infection_Homo sapiens_hsa051501.39480938
26Linoleic acid metabolism_Homo sapiens_hsa005911.36947504
27Collecting duct acid secretion_Homo sapiens_hsa049661.29707271
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28068009
29RNA polymerase_Homo sapiens_hsa030201.20362848
30Nitrogen metabolism_Homo sapiens_hsa009101.19945295
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19593066
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19472056
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13443370
34Regulation of autophagy_Homo sapiens_hsa041401.09456669
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05029190
36T cell receptor signaling pathway_Homo sapiens_hsa046601.01968982
37Caffeine metabolism_Homo sapiens_hsa002320.97929288
38NF-kappa B signaling pathway_Homo sapiens_hsa040640.97018343
39Leishmaniasis_Homo sapiens_hsa051400.94059190
40NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88473992
41Olfactory transduction_Homo sapiens_hsa047400.87823848
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86085518
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80564441
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79913565
45Arachidonic acid metabolism_Homo sapiens_hsa005900.79310933
46Peroxisome_Homo sapiens_hsa041460.75444113
47Systemic lupus erythematosus_Homo sapiens_hsa053220.74567796
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72312112
49Salmonella infection_Homo sapiens_hsa051320.71102343
50Tryptophan metabolism_Homo sapiens_hsa003800.70029104
51Chemical carcinogenesis_Homo sapiens_hsa052040.69084550
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.69033552
53Ether lipid metabolism_Homo sapiens_hsa005650.66923997
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.64400035
55Morphine addiction_Homo sapiens_hsa050320.63591031
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62715232
57Nicotine addiction_Homo sapiens_hsa050330.61455585
58Sulfur metabolism_Homo sapiens_hsa009200.58675919
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.57750968
60Butanoate metabolism_Homo sapiens_hsa006500.55234460
61RNA degradation_Homo sapiens_hsa030180.53961737
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53322065
63Homologous recombination_Homo sapiens_hsa034400.53031189
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50860031
65Malaria_Homo sapiens_hsa051440.49936513
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49685891
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48861536
68Phagosome_Homo sapiens_hsa041450.48770309
69Retinol metabolism_Homo sapiens_hsa008300.48749231
70Fat digestion and absorption_Homo sapiens_hsa049750.47789715
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47266523
72Tuberculosis_Homo sapiens_hsa051520.46413640
73Herpes simplex infection_Homo sapiens_hsa051680.45985363
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45132246
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44863874
76Purine metabolism_Homo sapiens_hsa002300.44581582
77Propanoate metabolism_Homo sapiens_hsa006400.44229306
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44118698
79Measles_Homo sapiens_hsa051620.43607433
80Shigellosis_Homo sapiens_hsa051310.41029372
81GABAergic synapse_Homo sapiens_hsa047270.38045062
82Legionellosis_Homo sapiens_hsa051340.36553634
83Mineral absorption_Homo sapiens_hsa049780.35797407
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35062658
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.33974665
86Chemokine signaling pathway_Homo sapiens_hsa040620.33972115
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33833444
88Fanconi anemia pathway_Homo sapiens_hsa034600.33222489
89Metabolic pathways_Homo sapiens_hsa011000.32573880
90One carbon pool by folate_Homo sapiens_hsa006700.31521406
91Salivary secretion_Homo sapiens_hsa049700.31474604
92Pyrimidine metabolism_Homo sapiens_hsa002400.30844952
93Taste transduction_Homo sapiens_hsa047420.29498825
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29253657
95Serotonergic synapse_Homo sapiens_hsa047260.27718263
96Pertussis_Homo sapiens_hsa051330.27068657
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26519301
98Circadian entrainment_Homo sapiens_hsa047130.23869834
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.22235605
100beta-Alanine metabolism_Homo sapiens_hsa004100.18762575

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