FTH1P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.49720957
2regulation of activation of Janus kinase activity (GO:0010533)5.36938319
3neutrophil activation (GO:0042119)4.07519198
4granulocyte activation (GO:0036230)3.98170351
5positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.93730999
6positive regulation of mast cell activation (GO:0033005)3.83935174
7negative regulation of interleukin-12 production (GO:0032695)3.71119576
8regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.67275151
9positive regulation of mast cell activation involved in immune response (GO:0033008)3.64792969
10positive regulation of mast cell degranulation (GO:0043306)3.64792969
11T-helper 1 type immune response (GO:0042088)3.64369362
12response to peptidoglycan (GO:0032494)3.53773028
13immunoglobulin mediated immune response (GO:0016064)3.51170647
14positive regulation by symbiont of host defense response (GO:0052509)3.39356226
15modulation by symbiont of host defense response (GO:0052031)3.39356226
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.39356226
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.39356226
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.39356226
19modulation by symbiont of host immune response (GO:0052553)3.39356226
20growth hormone receptor signaling pathway (GO:0060396)3.36609493
21regulation of mast cell activation (GO:0033003)3.28857027
22regulation of vitamin D biosynthetic process (GO:0060556)3.25001880
23phagosome maturation (GO:0090382)3.18555687
24detection of molecule of bacterial origin (GO:0032490)3.13481061
25positive regulation of NF-kappaB import into nucleus (GO:0042346)3.10472883
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09862255
27negative regulation of interleukin-1 beta production (GO:0032691)3.09181761
28negative regulation of interleukin-1 production (GO:0032692)3.08992559
29microglial cell activation (GO:0001774)3.08149447
30regulation of mast cell degranulation (GO:0043304)3.05700407
31positive regulation of interleukin-17 production (GO:0032740)3.04087374
32cellular response to zinc ion (GO:0071294)3.03380939
33macrophage activation involved in immune response (GO:0002281)3.02936245
34regulation of platelet activation (GO:0010543)3.00257350
35negative regulation of interleukin-17 production (GO:0032700)2.98718845
36protein neddylation (GO:0045116)2.96669490
37regulation of interleukin-6 biosynthetic process (GO:0045408)2.93374276
38regulation of mast cell activation involved in immune response (GO:0033006)2.91656606
39response to host immune response (GO:0052572)2.89924106
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.89924106
41cellular response to growth hormone stimulus (GO:0071378)2.89174505
42myeloid cell activation involved in immune response (GO:0002275)2.88832331
43regulation of interleukin-17 production (GO:0032660)2.82230313
44B cell mediated immunity (GO:0019724)2.82017972
45positive regulation of type 2 immune response (GO:0002830)2.80013264
46negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.79700256
47positive regulation of monocyte chemotaxis (GO:0090026)2.77283319
48platelet dense granule organization (GO:0060155)2.76139145
49regulation of memory T cell differentiation (GO:0043380)2.75447052
50interferon-gamma-mediated signaling pathway (GO:0060333)2.75326031
51positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.74548912
52lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73388742
53positive regulation of leukocyte degranulation (GO:0043302)2.72358190
54negative regulation of mast cell activation (GO:0033004)2.71350693
55cellular response to arsenic-containing substance (GO:0071243)2.69582116
56regulation of antigen processing and presentation (GO:0002577)2.68569495
57thrombin receptor signaling pathway (GO:0070493)2.68294321
58regulation of T-helper 1 cell differentiation (GO:0045625)2.65996695
59regulation of platelet aggregation (GO:0090330)2.64907469
60positive regulation of antigen processing and presentation (GO:0002579)2.64176290
61superoxide anion generation (GO:0042554)2.64050114
62leukocyte degranulation (GO:0043299)2.62334553
63amine catabolic process (GO:0009310)2.61953890
64cellular biogenic amine catabolic process (GO:0042402)2.61953890
65regulation of mononuclear cell migration (GO:0071675)2.61850027
66positive regulation of toll-like receptor signaling pathway (GO:0034123)2.61669557
67positive regulation of T-helper 1 type immune response (GO:0002827)2.61402488
68regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.60195624
69regulation of vitamin metabolic process (GO:0030656)2.57813599
70regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57636554
71negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.56488067
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.56193351
73negative regulation of cell killing (GO:0031342)2.56193351
74purine nucleotide salvage (GO:0032261)2.56085193
75negative regulation of lipid storage (GO:0010888)2.54646169
76positive regulation of gamma-delta T cell activation (GO:0046645)2.53203377
77positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.51904968
78lipoxygenase pathway (GO:0019372)2.50535815
79regulation of T cell tolerance induction (GO:0002664)2.49406518
80cellular extravasation (GO:0045123)2.49395223
81regulation of interleukin-12 production (GO:0032655)2.47987559
82hydrogen peroxide biosynthetic process (GO:0050665)2.46751328
83positive regulation of interleukin-1 beta secretion (GO:0050718)2.46323436
84macrophage activation (GO:0042116)2.46056712
85regulation of T-helper 1 type immune response (GO:0002825)2.45556740
86regulation of monocyte chemotaxis (GO:0090025)2.45325628
87regulation of alpha-beta T cell proliferation (GO:0046640)2.43556897
88positive regulation of T-helper cell differentiation (GO:0045624)2.43425426
89positive regulation of interleukin-10 production (GO:0032733)2.43422336
90lymphocyte chemotaxis (GO:0048247)2.42557901
91energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.42324439
92ATP hydrolysis coupled proton transport (GO:0015991)2.42324439
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.41324316
94response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.40637071
95response to host (GO:0075136)2.40637071
96response to host defenses (GO:0052200)2.40637071
97positive regulation of alpha-beta T cell proliferation (GO:0046641)2.40119730
98neutrophil mediated immunity (GO:0002446)2.39922046
99defense response to protozoan (GO:0042832)2.39866798
100positive regulation of interleukin-12 production (GO:0032735)2.39851397

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.39059295
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.23868709
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.03313923
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.84838127
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.50783141
6LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.96372994
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86531088
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.70012012
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68835797
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.64883067
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.59185168
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.50432784
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47569052
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42054746
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.41025901
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32338988
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26866679
18LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.22224958
19MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.19136043
20SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.16600549
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08887838
22SPI1_23547873_ChIP-Seq_NB4_Human1.99516576
23SPI1_23127762_ChIP-Seq_K562_Human1.96682297
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91254877
25STAT1_20625510_ChIP-Seq_HELA_Human1.88825299
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84578684
27GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.80966204
28SCL_19346495_ChIP-Seq_HPC-7_Human1.78784601
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70095213
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63854992
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58576449
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53860446
33CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48304863
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.47883240
35RUNX_20019798_ChIP-Seq_JUKART_Human1.45406995
36GATA1_19941826_ChIP-Seq_K562_Human1.44032602
37BCL6_27268052_Chip-Seq_Bcells_Human1.33180145
38SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32874157
39CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32575958
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32495072
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32467647
42GATA3_26560356_Chip-Seq_TH2_Human1.30677768
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.30395709
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30077797
45GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28677739
46PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26275288
47GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24951690
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24351034
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24189314
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23263344
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.22556162
52VDR_22108803_ChIP-Seq_LS180_Human1.20522871
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20171156
54CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19857362
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18518050
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.17059960
57MYB_26560356_Chip-Seq_TH2_Human1.15713021
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15574685
59GATA2_19941826_ChIP-Seq_K562_Human1.15422079
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14766065
61VDR_24787735_ChIP-Seq_THP-1_Human1.14419344
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13687739
63TP53_22573176_ChIP-Seq_HFKS_Human1.09917861
64SPI1_20517297_ChIP-Seq_HL60_Human1.08449198
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08301695
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05847277
67BCOR_27268052_Chip-Seq_Bcells_Human1.05815113
68TAF2_19829295_ChIP-Seq_ESCs_Human1.03869576
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.02478889
70AR_20517297_ChIP-Seq_VCAP_Human1.02431818
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00814968
72UTX_26944678_Chip-Seq_JUKART_Human0.97655600
73PU_27001747_Chip-Seq_BMDM_Mouse0.97471783
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96368306
75ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95032923
76GATA3_27048872_Chip-Seq_THYMUS_Human0.92614880
77NANOG_20526341_ChIP-Seq_ESCs_Human0.92603878
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92176642
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91761846
80YY1_22570637_ChIP-Seq_MALME-3M_Human0.91701060
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90849844
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90605257
83VDR_24763502_ChIP-Seq_THP-1_Human0.90377452
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88788701
85TFEB_21752829_ChIP-Seq_HELA_Human0.87821406
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86178285
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85904154
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85023932
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.84408251
90EGR1_19032775_ChIP-ChIP_M12_Human0.83814727
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83506152
92SRF_21415370_ChIP-Seq_HL-1_Mouse0.82506769
93SOX2_20726797_ChIP-Seq_SW620_Human0.81546609
94ERG_20517297_ChIP-Seq_VCAP_Human0.80441925
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80164780
96HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79123844
97RXR_22158963_ChIP-Seq_LIVER_Mouse0.77643715
98SOX2_19829295_ChIP-Seq_ESCs_Human0.77165116
99NANOG_19829295_ChIP-Seq_ESCs_Human0.77165116
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76918244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.28884535
2MP0003303_peritoneal_inflammation3.76149234
3MP0005464_abnormal_platelet_physiology3.62637347
4MP0001835_abnormal_antigen_presentation3.25650478
5MP0002148_abnormal_hypersensitivity_rea3.21815812
6MP0003806_abnormal_nucleotide_metabolis3.03545505
7MP0009785_altered_susceptibility_to2.96594366
8MP0009764_decreased_sensitivity_to2.93287085
9MP0005451_abnormal_body_composition2.84424432
10MP0005671_abnormal_response_to2.70104536
11MP0003436_decreased_susceptibility_to2.46529804
12MP0005000_abnormal_immune_tolerance2.36294189
13MP0000343_altered_response_to2.33072389
14MP0002419_abnormal_innate_immunity2.30232847
15MP0008004_abnormal_stomach_pH2.15682133
16MP0002723_abnormal_immune_serum2.10006662
17MP0002452_abnormal_antigen_presenting2.06519047
18MP0005025_abnormal_response_to2.05915028
19MP0005058_abnormal_lysosome_morphology2.05576578
20MP0001800_abnormal_humoral_immune2.01219969
21MP0000685_abnormal_immune_system1.96423595
22MP0003656_abnormal_erythrocyte_physiolo1.81699803
23MP0003075_altered_response_to1.81209244
24MP0005387_immune_system_phenotype1.80332341
25MP0001790_abnormal_immune_system1.80332341
26MP0003195_calcinosis1.79231653
27MP0001845_abnormal_inflammatory_respons1.74199037
28MP0001819_abnormal_immune_cell1.69740969
29MP0005167_abnormal_blood-brain_barrier1.66510728
30MP0002420_abnormal_adaptive_immunity1.65835191
31MP0001533_abnormal_skeleton_physiology1.62467478
32MP0003186_abnormal_redox_activity1.57347299
33MP0004510_myositis1.55205487
34MP0006082_CNS_inflammation1.54871246
35MP0003172_abnormal_lysosome_physiology1.54714473
36MP0000372_irregular_coat_pigmentation1.54230138
37MP0009765_abnormal_xenobiotic_induced1.49521599
38MP0010155_abnormal_intestine_physiology1.47861512
39MP0008469_abnormal_protein_level1.47371852
40MP0002139_abnormal_hepatobiliary_system1.46699417
41MP0009840_abnormal_foam_cell1.44065228
42MP0000465_gastrointestinal_hemorrhage1.42429190
43MP0004947_skin_inflammation1.40907896
44MP0000015_abnormal_ear_pigmentation1.40825059
45MP0008260_abnormal_autophagy1.36642682
46MP0009333_abnormal_splenocyte_physiolog1.32878089
47MP0003011_delayed_dark_adaptation1.32851276
48MP0009278_abnormal_bone_marrow1.27773912
49MP0002405_respiratory_system_inflammati1.27526492
50MP0009763_increased_sensitivity_to1.21999407
51MP0001545_abnormal_hematopoietic_system1.20981856
52MP0005397_hematopoietic_system_phenotyp1.20981856
53MP0002837_dystrophic_cardiac_calcinosis1.15694322
54MP0003828_pulmonary_edema1.15581632
55MP0005410_abnormal_fertilization1.13986667
56MP0000858_altered_metastatic_potential1.11798136
57MP0005166_decreased_susceptibility_to1.08871115
58MP0001663_abnormal_digestive_system1.07775370
59MP0000716_abnormal_immune_system1.07386244
60MP0003300_gastrointestinal_ulcer1.06455774
61MP0000604_amyloidosis1.04674379
62MP0002398_abnormal_bone_marrow1.03822934
63MP0002095_abnormal_skin_pigmentation1.02241680
64MP0005164_abnormal_response_to0.99225527
65MP0002277_abnormal_respiratory_mucosa0.97936798
66MP0005646_abnormal_pituitary_gland0.97236168
67MP0005084_abnormal_gallbladder_morpholo0.97118952
68MP0003136_yellow_coat_color0.97020203
69MP0003183_abnormal_peptide_metabolism0.93041820
70MP0004147_increased_porphyrin_level0.92925313
71MP0002429_abnormal_blood_cell0.92814394
72MP0002998_abnormal_bone_remodeling0.91846594
73MP0003191_abnormal_cellular_cholesterol0.90277745
74MP0002138_abnormal_hepatobiliary_system0.89586709
75MP0000230_abnormal_systemic_arterial0.88108849
76MP0008875_abnormal_xenobiotic_pharmacok0.87086569
77MP0003045_fibrosis0.86208146
78MP0004381_abnormal_hair_follicle0.85284505
79MP0006054_spinal_hemorrhage0.84355752
80MP0000689_abnormal_spleen_morphology0.84298837
81MP0000371_diluted_coat_color0.83466331
82MP0003646_muscle_fatigue0.83144917
83MP0003878_abnormal_ear_physiology0.83035613
84MP0005377_hearing/vestibular/ear_phenot0.83035613
85MP0003448_altered_tumor_morphology0.81525072
86MP0008872_abnormal_physiological_respon0.81283130
87MP0005075_abnormal_melanosome_morpholog0.80663996
88MP0005319_abnormal_enzyme/_coenzyme0.76236632
89MP0003638_abnormal_response/metabolism_0.75760052
90MP0002332_abnormal_exercise_endurance0.74690784
91MP0003879_abnormal_hair_cell0.73086105
92MP0002736_abnormal_nociception_after0.71897346
93MP0000249_abnormal_blood_vessel0.71646602
94MP0003866_abnormal_defecation0.71370445
95MP0004885_abnormal_endolymph0.70071363
96MP0006036_abnormal_mitochondrial_physio0.69418476
97MP0002722_abnormal_immune_system0.69088565
98MP0001542_abnormal_bone_strength0.68566779
99MP0002132_abnormal_respiratory_system0.67568646
100MP0005083_abnormal_biliary_tract0.67541819

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)4.93666338
2Abnormality of liposaccharide metabolism (HP:0010968)4.18385616
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.18385616
4Abnormality of glycolipid metabolism (HP:0010969)4.18385616
5Prolonged bleeding time (HP:0003010)4.08557937
6Stomatitis (HP:0010280)4.07715727
7Purpura (HP:0000979)4.05405142
8Abnormality of the heme biosynthetic pathway (HP:0010472)3.70890937
9Gastrointestinal infarctions (HP:0005244)3.59405961
10Epistaxis (HP:0000421)3.55567634
11Recurrent abscess formation (HP:0002722)3.52930439
12Abnormality of macrophages (HP:0004311)3.46990069
13Elevated erythrocyte sedimentation rate (HP:0003565)3.44723071
14Chronic obstructive pulmonary disease (HP:0006510)3.41413725
15Obstructive lung disease (HP:0006536)3.41413725
16Optic neuritis (HP:0100653)3.38878455
17Retrobulbar optic neuritis (HP:0100654)3.38878455
18Orchitis (HP:0100796)3.37473404
19Recurrent bacterial skin infections (HP:0005406)3.34379087
20Gingival bleeding (HP:0000225)3.33857684
21Myositis (HP:0100614)3.33443428
22Hemoptysis (HP:0002105)3.21376543
23Abnormal hemoglobin (HP:0011902)3.16118540
24Increased IgM level (HP:0003496)3.10620667
25Decreased central vision (HP:0007663)3.00390056
26Vasculitis (HP:0002633)3.00225631
27Spontaneous hematomas (HP:0007420)2.94330739
28Menorrhagia (HP:0000132)2.94280950
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.93373293
30Eczematoid dermatitis (HP:0000976)2.88500103
31Anorexia (HP:0002039)2.82776294
32Abnormal platelet volume (HP:0011876)2.74469956
33Increased mean platelet volume (HP:0011877)2.69815189
34Gangrene (HP:0100758)2.64241896
35Mediastinal lymphadenopathy (HP:0100721)2.63818208
36Urticaria (HP:0001025)2.62835456
37Generalized aminoaciduria (HP:0002909)2.58035954
38Nausea (HP:0002018)2.56635321
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.55621664
403-Methylglutaconic aciduria (HP:0003535)2.52621038
41Dysostosis multiplex (HP:0000943)2.51164227
42Recurrent gram-negative bacterial infections (HP:0005420)2.46898272
43Constricted visual fields (HP:0001133)2.43929438
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42596107
45Abnormality of alanine metabolism (HP:0010916)2.42596107
46Hyperalaninemia (HP:0003348)2.42596107
47Increased serum ferritin (HP:0003281)2.42133929
48Impaired platelet aggregation (HP:0003540)2.39530365
49Abnormal platelet function (HP:0011869)2.39530365
50Pulmonary infiltrates (HP:0002113)2.38603862
51Arterial thrombosis (HP:0004420)2.33860374
52Pulmonary embolism (HP:0002204)2.32044095
53Episodic fever (HP:0001954)2.30878771
54Hyperlipoproteinemia (HP:0010980)2.30257320
55Muscle fibrillation (HP:0010546)2.26047708
56Vacuolated lymphocytes (HP:0001922)2.23802767
57Abnormality of iron homeostasis (HP:0011031)2.23168179
58Leukocytosis (HP:0001974)2.21951492
59Chest pain (HP:0100749)2.19830295
60Tongue fasciculations (HP:0001308)2.18714066
61Abnormality of the vasculature of the conjunctiva (HP:0008054)2.18321193
62Encephalitis (HP:0002383)2.18273098
63Keratoconjunctivitis sicca (HP:0001097)2.18011209
64Paralysis (HP:0003470)2.15797581
65Albinism (HP:0001022)2.15512775
66Abnormality of transition element cation homeostasis (HP:0011030)2.15303295
67Microcytic anemia (HP:0001935)2.12250364
68Agitation (HP:0000713)2.11867770
69Myocardial infarction (HP:0001658)2.09081117
70Pustule (HP:0200039)2.07636626
71Joint swelling (HP:0001386)2.07377094
72Congenital sensorineural hearing impairment (HP:0008527)2.02341844
73Peritonitis (HP:0002586)2.01580402
74Hepatosplenomegaly (HP:0001433)1.98772983
75Acute necrotizing encephalopathy (HP:0006965)1.98317844
76Keratoconjunctivitis (HP:0001096)1.96823743
77Increased cerebral lipofuscin (HP:0011813)1.94929213
78Recurrent fungal infections (HP:0002841)1.93740572
79Meningitis (HP:0001287)1.93309316
80Glomerulopathy (HP:0100820)1.92290685
81Thrombophlebitis (HP:0004418)1.90780241
82Congenital stationary night blindness (HP:0007642)1.88700453
83Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88099765
84Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88099765
85Abnormality of polysaccharide metabolism (HP:0011012)1.88099765
86Abnormality of the prostate (HP:0008775)1.86302495
87Recurrent skin infections (HP:0001581)1.85782248
88Hypergammaglobulinemia (HP:0010702)1.83651909
89Abnormality of the pericardium (HP:0001697)1.83153817
90Progressive macrocephaly (HP:0004481)1.82946848
91Abnormality of the costochondral junction (HP:0000919)1.81728826
92Acute encephalopathy (HP:0006846)1.81377203
93Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80821950
94Progressive neurologic deterioration (HP:0002344)1.80420268
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77582220
96Amyloidosis (HP:0011034)1.77512772
97Systemic lupus erythematosus (HP:0002725)1.76583966
98Poikilocytosis (HP:0004447)1.76493210
99Cerebral ischemia (HP:0002637)1.75802445
100Arthralgia (HP:0002829)1.75604172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.16375643
2RIPK43.12850360
3TAOK32.58260581
4TXK2.58221127
5BLK2.53566732
6MAP3K112.48201222
7JAK32.42415842
8SIK32.41247343
9MAP3K142.31040119
10MATK2.25884725
11MAP4K11.98317061
12IKBKB1.98019436
13BMPR21.97875741
14IRAK41.94409916
15CDK191.93054392
16TLK11.92619180
17MAP3K31.89183761
18FGR1.81595968
19GRK61.79199398
20SYK1.73534515
21GRK71.66381533
22ADRBK21.58271861
23PIM21.58173198
24IKBKE1.52924954
25MARK31.46811058
26CSF1R1.42701905
27CSK1.40544081
28FES1.36133325
29TBK11.33164077
30KIT1.29448989
31NME21.28635797
32ACVR1B1.25613659
33TAOK11.24184632
34MAP4K21.23774090
35EPHA31.21798927
36BTK1.20546192
37SIK21.17362452
38LYN1.14517059
39MAP2K31.11879305
40ZAP701.11550966
41EIF2AK11.11333548
42MST41.10176714
43PTK2B1.10020940
44TAOK21.09849625
45IRAK11.09602217
46EPHB21.07201497
47TEC1.07076374
48BCKDK1.04181263
49HCK1.04103011
50ABL20.99618976
51TYK20.98816320
52MYLK0.93640196
53DDR20.93434438
54MAP3K120.92618930
55TGFBR20.83701916
56PIK3CG0.82890901
57MAPKAPK30.81727502
58CAMKK20.80731769
59MAP3K10.79480059
60GRK10.79324960
61JAK20.78407374
62DAPK20.77436814
63MAP3K130.75729536
64TESK20.75723916
65PINK10.74225912
66ERN10.71999188
67MAP3K50.70743399
68CHUK0.69606334
69EPHB10.67021435
70GRK50.66378921
71PIM10.66266150
72LCK0.65565194
73PRKCD0.61834972
74BMX0.60610488
75OXSR10.60431664
76TRIM280.59680183
77IRAK20.59130887
78KDR0.58473632
79ADRBK10.54015701
80TNK20.53466901
81PLK20.53446692
82ITK0.53041731
83ARAF0.51315068
84PRKG20.50246788
85DYRK30.50108472
86FER0.49772325
87NUAK10.49205447
88PDK20.45485102
89SIK10.42819997
90PRKCQ0.41779054
91WNK40.41732183
92RPS6KA50.41687459
93DYRK1B0.40821183
94CSNK1G30.40279109
95ABL10.38978543
96TIE10.38938510
97PRKD20.38012306
98STK160.36941497
99PAK10.36598161
100IGF1R0.36538653

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.30232027
2Allograft rejection_Homo sapiens_hsa053303.28280794
3Rheumatoid arthritis_Homo sapiens_hsa053233.20849634
4Graft-versus-host disease_Homo sapiens_hsa053323.10160251
5Staphylococcus aureus infection_Homo sapiens_hsa051502.92552848
6Autoimmune thyroid disease_Homo sapiens_hsa053202.82297115
7Collecting duct acid secretion_Homo sapiens_hsa049662.75750449
8Type I diabetes mellitus_Homo sapiens_hsa049402.75703270
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.69627157
10Leishmaniasis_Homo sapiens_hsa051402.54424731
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38099648
12Sulfur metabolism_Homo sapiens_hsa009202.04203114
13Phagosome_Homo sapiens_hsa041452.00672005
14Tuberculosis_Homo sapiens_hsa051521.87675091
15Malaria_Homo sapiens_hsa051441.85170209
16Antigen processing and presentation_Homo sapiens_hsa046121.80139097
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80056610
18Osteoclast differentiation_Homo sapiens_hsa043801.77226617
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77028553
20Hematopoietic cell lineage_Homo sapiens_hsa046401.76809983
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65202731
22Lysosome_Homo sapiens_hsa041421.53300224
23Legionellosis_Homo sapiens_hsa051341.50922097
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49526291
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48439663
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.48232740
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.46183200
28Caffeine metabolism_Homo sapiens_hsa002321.42277423
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41549680
30Oxidative phosphorylation_Homo sapiens_hsa001901.39333750
31Chemokine signaling pathway_Homo sapiens_hsa040621.36535842
32Viral myocarditis_Homo sapiens_hsa054161.35655598
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28396602
34Toxoplasmosis_Homo sapiens_hsa051451.25537402
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18142214
36TNF signaling pathway_Homo sapiens_hsa046681.14086527
37Regulation of autophagy_Homo sapiens_hsa041401.12526940
38Vibrio cholerae infection_Homo sapiens_hsa051101.11154910
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11036895
40Platelet activation_Homo sapiens_hsa046111.10620319
41Influenza A_Homo sapiens_hsa051641.06967032
42Salmonella infection_Homo sapiens_hsa051321.05761777
43Pertussis_Homo sapiens_hsa051331.02665403
44Shigellosis_Homo sapiens_hsa051311.02540515
45Other glycan degradation_Homo sapiens_hsa005111.02520229
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00988147
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95852453
48Mineral absorption_Homo sapiens_hsa049780.95820222
49African trypanosomiasis_Homo sapiens_hsa051430.94707061
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93856729
51Herpes simplex infection_Homo sapiens_hsa051680.84895607
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.82597257
53Nitrogen metabolism_Homo sapiens_hsa009100.79873882
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79451930
55Synaptic vesicle cycle_Homo sapiens_hsa047210.75859101
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73582743
57Parkinsons disease_Homo sapiens_hsa050120.72322306
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71581382
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71292562
60Arachidonic acid metabolism_Homo sapiens_hsa005900.69889769
61Measles_Homo sapiens_hsa051620.69519323
62Primary immunodeficiency_Homo sapiens_hsa053400.67355788
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65760438
64Proteasome_Homo sapiens_hsa030500.57897619
65Systemic lupus erythematosus_Homo sapiens_hsa053220.57021923
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56993078
67B cell receptor signaling pathway_Homo sapiens_hsa046620.53780463
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52621709
69Morphine addiction_Homo sapiens_hsa050320.46782447
70Glutathione metabolism_Homo sapiens_hsa004800.43221622
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42587335
72Tryptophan metabolism_Homo sapiens_hsa003800.42569996
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41423005
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40301922
75Chemical carcinogenesis_Homo sapiens_hsa052040.40238916
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39114628
77PPAR signaling pathway_Homo sapiens_hsa033200.37867563
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.37470494
79Peroxisome_Homo sapiens_hsa041460.36127496
80Apoptosis_Homo sapiens_hsa042100.36063961
81Linoleic acid metabolism_Homo sapiens_hsa005910.36059382
82Endocytosis_Homo sapiens_hsa041440.35867621
83Selenocompound metabolism_Homo sapiens_hsa004500.35865255
84Galactose metabolism_Homo sapiens_hsa000520.35364825
85Alzheimers disease_Homo sapiens_hsa050100.34380424
86Hepatitis C_Homo sapiens_hsa051600.34370196
87Bladder cancer_Homo sapiens_hsa052190.33505275
88Complement and coagulation cascades_Homo sapiens_hsa046100.31537021
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.31269841
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.30980852
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30792870
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30501815
93Olfactory transduction_Homo sapiens_hsa047400.28941527
94Epstein-Barr virus infection_Homo sapiens_hsa051690.28639890
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28625529
96T cell receptor signaling pathway_Homo sapiens_hsa046600.27551337
97GABAergic synapse_Homo sapiens_hsa047270.26384853
98Glycerolipid metabolism_Homo sapiens_hsa005610.26155071
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24597642
100Phototransduction_Homo sapiens_hsa047440.23847546

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