FTH1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)6.46802100
2cytidine metabolic process (GO:0046087)6.46802100
3cytidine catabolic process (GO:0006216)6.46802100
4DNA deamination (GO:0045006)6.34204705
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.80450639
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.57942093
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.96207655
8actin nucleation (GO:0045010)4.44356789
9immunoglobulin mediated immune response (GO:0016064)3.96624246
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96297068
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84130866
12negative regulation of T cell apoptotic process (GO:0070233)3.62842113
13ATP synthesis coupled proton transport (GO:0015986)3.62534030
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.62534030
15protein neddylation (GO:0045116)3.60742374
16sequestering of actin monomers (GO:0042989)3.60244640
17positive thymic T cell selection (GO:0045059)3.45864700
18positive regulation of interleukin-8 secretion (GO:2000484)3.40695011
19regulation of regulatory T cell differentiation (GO:0045589)3.39704559
20T cell costimulation (GO:0031295)3.35925745
21pyrimidine nucleoside catabolic process (GO:0046135)3.35380720
22regulation of chronic inflammatory response (GO:0002676)3.34027295
23lymphocyte costimulation (GO:0031294)3.33050505
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32879762
25eosinophil chemotaxis (GO:0048245)3.29465670
26regulation of activation of Janus kinase activity (GO:0010533)3.27765213
27positive regulation of calcium-mediated signaling (GO:0050850)3.23395015
28regulation of interleukin-8 secretion (GO:2000482)3.23045469
29platelet dense granule organization (GO:0060155)3.22711134
30respiratory electron transport chain (GO:0022904)3.22690941
31electron transport chain (GO:0022900)3.21560241
32regulation of B cell receptor signaling pathway (GO:0050855)3.20901989
33positive regulation of monocyte chemotaxis (GO:0090026)3.20467509
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17931934
35B cell mediated immunity (GO:0019724)3.17867650
36positive regulation of B cell differentiation (GO:0045579)3.14304439
37positive T cell selection (GO:0043368)3.13909691
38T cell migration (GO:0072678)3.12263247
39positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11790800
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.11299627
41positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.03365940
42response to interferon-beta (GO:0035456)3.01311073
43positive regulation of gamma-delta T cell activation (GO:0046645)3.00654246
44T cell receptor signaling pathway (GO:0050852)3.00222905
45antigen processing and presentation via MHC class Ib (GO:0002475)2.99614654
46eosinophil migration (GO:0072677)2.99252688
47positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98690490
48negative regulation of viral genome replication (GO:0045071)2.97709502
49regulation of T cell tolerance induction (GO:0002664)2.97574449
50mast cell activation (GO:0045576)2.95988946
51positive regulation of natural killer cell mediated immunity (GO:0002717)2.95520958
52regulation of leukocyte mediated cytotoxicity (GO:0001910)2.90551034
53positive regulation of interleukin-17 production (GO:0032740)2.89578175
54regulation of natural killer cell mediated immunity (GO:0002715)2.87442565
55regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.87442565
56regulation of T cell mediated cytotoxicity (GO:0001914)2.85069251
57positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.83584502
58negative regulation of lymphocyte apoptotic process (GO:0070229)2.81602896
59macrophage chemotaxis (GO:0048246)2.80031033
60regulation of alpha-beta T cell proliferation (GO:0046640)2.79217264
61positive regulation of defense response to virus by host (GO:0002230)2.79107518
62regulation of cellular amino acid metabolic process (GO:0006521)2.78151640
63granulocyte activation (GO:0036230)2.77549022
64negative T cell selection (GO:0043383)2.77192868
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.76828175
66cellular response to interleukin-15 (GO:0071350)2.75748204
67positive regulation of interleukin-1 beta secretion (GO:0050718)2.75680104
68positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.75052520
69antigen receptor-mediated signaling pathway (GO:0050851)2.74928066
70neutrophil activation (GO:0042119)2.74532164
71antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.73685038
72positive regulation of cell killing (GO:0031343)2.71848055
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.67663625
74positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65969797
75neutrophil activation involved in immune response (GO:0002283)2.65651081
76regulation of T cell receptor signaling pathway (GO:0050856)2.65386598
77interferon-gamma-mediated signaling pathway (GO:0060333)2.64518782
78regulation of cell killing (GO:0031341)2.64260149
79negative regulation by host of viral transcription (GO:0043922)2.63709847
80lymphocyte chemotaxis (GO:0048247)2.63534880
81positive regulation of interleukin-1 secretion (GO:0050716)2.62291068
82cytolysis (GO:0019835)2.61036616
83positive regulation of lymphocyte migration (GO:2000403)2.59922661
84regulation of T cell apoptotic process (GO:0070232)2.59848384
85negative regulation of mast cell activation (GO:0033004)2.59717222
86regulation of B cell differentiation (GO:0045577)2.59488898
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59080310
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59080310
89regulation of tolerance induction (GO:0002643)2.58994535
90regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.55455561
91regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.55313836
92regulation of interleukin-1 beta secretion (GO:0050706)2.54972496
93hydrogen ion transmembrane transport (GO:1902600)2.54029431
94negative regulation of calcium ion transport into cytosol (GO:0010523)2.53421846
95positive regulation of tolerance induction (GO:0002645)2.52439712
96cellular defense response (GO:0006968)2.49158763
97proton transport (GO:0015992)2.47883407
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.47781512
99iron-sulfur cluster assembly (GO:0016226)2.47541634
100metallo-sulfur cluster assembly (GO:0031163)2.47541634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.41400431
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.59698111
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.59537500
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.56383095
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.44976967
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.15486271
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.89979616
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85385199
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73135517
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.35131629
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.25861201
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25761826
13VDR_22108803_ChIP-Seq_LS180_Human2.22814652
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12524808
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05743964
16MYB_26560356_Chip-Seq_TH2_Human2.03237867
17IGF1R_20145208_ChIP-Seq_DFB_Human1.96259080
18STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87152092
19VDR_23849224_ChIP-Seq_CD4+_Human1.85519553
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83948975
21RUNX_20019798_ChIP-Seq_JUKART_Human1.80483450
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80156836
23GATA3_26560356_Chip-Seq_TH2_Human1.77169078
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.76154676
25ZNF274_21170338_ChIP-Seq_K562_Hela1.76141299
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75629671
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75382093
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68481049
29GATA3_27048872_Chip-Seq_THYMUS_Human1.66731822
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63078831
31EZH2_22144423_ChIP-Seq_EOC_Human1.58295201
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57746023
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51705739
34TP53_22573176_ChIP-Seq_HFKS_Human1.51331571
35SPI1_23547873_ChIP-Seq_NB4_Human1.38792814
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.38174535
37PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.36566777
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.36318197
39AR_20517297_ChIP-Seq_VCAP_Human1.35648738
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.35199253
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32567869
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32550993
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31380649
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29257124
45BCL6_27268052_Chip-Seq_Bcells_Human1.28943770
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28939756
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.28440855
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28179319
49TAF2_19829295_ChIP-Seq_ESCs_Human1.27861093
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.26547212
51FOXP3_21729870_ChIP-Seq_TREG_Human1.23184680
52NANOG_20526341_ChIP-Seq_ESCs_Human1.22056676
53HTT_18923047_ChIP-ChIP_STHdh_Human1.21313438
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20529926
55MYB_26560356_Chip-Seq_TH1_Human1.19843649
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19574544
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.19574544
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16109256
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15833377
60NANOG_19829295_ChIP-Seq_ESCs_Human1.14651165
61SOX2_19829295_ChIP-Seq_ESCs_Human1.14651165
62TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13073323
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.12141231
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10857569
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08858836
66ELK1_19687146_ChIP-ChIP_HELA_Human1.07270424
67ERG_20517297_ChIP-Seq_VCAP_Human1.05032096
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04761834
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03648108
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03190180
71STAT1_20625510_ChIP-Seq_HELA_Human1.03179653
72P300_27268052_Chip-Seq_Bcells_Human1.03019003
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02997845
74CIITA_25753668_ChIP-Seq_RAJI_Human1.02491389
75MYC_19829295_ChIP-Seq_ESCs_Human1.01700214
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01248700
77UTX_26944678_Chip-Seq_JUKART_Human0.99336255
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97405983
79ELF1_20517297_ChIP-Seq_JURKAT_Human0.97229195
80NCOR_22424771_ChIP-Seq_293T_Human0.95488317
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95419989
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95005702
83MYC_18940864_ChIP-ChIP_HL60_Human0.94628090
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94601101
85TAF15_26573619_Chip-Seq_HEK293_Human0.94517301
86SCL_19346495_ChIP-Seq_HPC-7_Human0.93097470
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91058788
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90320268
89EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90283511
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90202583
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89944266
92CBP_20019798_ChIP-Seq_JUKART_Human0.89742730
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89742730
94GATA3_26560356_Chip-Seq_TH1_Human0.89054234
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88009705
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87689051
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.87528624
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86909794
99SPI1_20517297_ChIP-Seq_HL60_Human0.86374606
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.85906442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.29440731
2MP0001835_abnormal_antigen_presentation4.07748645
3MP0009785_altered_susceptibility_to3.38411169
4MP0002148_abnormal_hypersensitivity_rea2.99366368
5MP0005000_abnormal_immune_tolerance2.71154995
6MP0003724_increased_susceptibility_to2.62848482
7MP0006082_CNS_inflammation2.53092488
8MP0001800_abnormal_humoral_immune2.46181379
9MP0005025_abnormal_response_to2.32156857
10MP0002723_abnormal_immune_serum2.31176459
11MP0005464_abnormal_platelet_physiology2.25450391
12MP0009764_decreased_sensitivity_to2.19858795
13MP0002420_abnormal_adaptive_immunity2.13023286
14MP0002452_abnormal_antigen_presenting2.11487221
15MP0001819_abnormal_immune_cell2.10219453
16MP0005387_immune_system_phenotype2.05885242
17MP0001790_abnormal_immune_system2.05885242
18MP0009333_abnormal_splenocyte_physiolog2.05374489
19MP0003763_abnormal_thymus_physiology1.95200488
20MP0003646_muscle_fatigue1.90314772
21MP0003806_abnormal_nucleotide_metabolis1.87975692
22MP0003436_decreased_susceptibility_to1.82967825
23MP0003866_abnormal_defecation1.75513711
24MP0002102_abnormal_ear_morphology1.72712621
25MP0010155_abnormal_intestine_physiology1.71208818
26MP0002419_abnormal_innate_immunity1.69736695
27MP0000372_irregular_coat_pigmentation1.69263392
28MP0000685_abnormal_immune_system1.66164650
29MP0001845_abnormal_inflammatory_respons1.60884430
30MP0002166_altered_tumor_susceptibility1.60322212
31MP0000716_abnormal_immune_system1.57126467
32MP0006072_abnormal_retinal_apoptosis1.54931197
33MP0001873_stomach_inflammation1.53865034
34MP0002398_abnormal_bone_marrow1.52876072
35MP0004147_increased_porphyrin_level1.47174524
36MP0003011_delayed_dark_adaptation1.45678610
37MP0008995_early_reproductive_senescence1.44321089
38MP0002138_abnormal_hepatobiliary_system1.36641434
39MP0002405_respiratory_system_inflammati1.33131490
40MP0005084_abnormal_gallbladder_morpholo1.32807017
41MP0005646_abnormal_pituitary_gland1.31865811
42MP0008469_abnormal_protein_level1.31183167
43MP0008872_abnormal_physiological_respon1.30626775
44MP0002876_abnormal_thyroid_physiology1.30432105
45MP0005645_abnormal_hypothalamus_physiol1.30081646
46MP0005075_abnormal_melanosome_morpholog1.29009488
47MP0003075_altered_response_to1.23398336
48MP0003195_calcinosis1.23167950
49MP0000689_abnormal_spleen_morphology1.21939195
50MP0002429_abnormal_blood_cell1.21298366
51MP0002006_tumorigenesis1.20750356
52MP0000465_gastrointestinal_hemorrhage1.20469833
53MP0008875_abnormal_xenobiotic_pharmacok1.20326624
54MP0005410_abnormal_fertilization1.18554291
55MP0002837_dystrophic_cardiac_calcinosis1.17892949
56MP0009763_increased_sensitivity_to1.13478112
57MP0005253_abnormal_eye_physiology1.09619964
58MP0002722_abnormal_immune_system1.09294826
59MP0005167_abnormal_blood-brain_barrier1.06472946
60MP0001905_abnormal_dopamine_level1.04446136
61MP0001919_abnormal_reproductive_system1.03991000
62MP0009379_abnormal_foot_pigmentation1.03032077
63MP0005166_decreased_susceptibility_to1.02971456
64MP0002277_abnormal_respiratory_mucosa1.02828873
65MP0006036_abnormal_mitochondrial_physio1.02379954
66MP0005551_abnormal_eye_electrophysiolog1.02084144
67MP0001533_abnormal_skeleton_physiology1.01876414
68MP0001853_heart_inflammation1.01311382
69MP0004142_abnormal_muscle_tone1.00618550
70MP0000343_altered_response_to0.98421742
71MP0006276_abnormal_autonomic_nervous0.98324696
72MP0010386_abnormal_urinary_bladder0.96760387
73MP0002933_joint_inflammation0.96444414
74MP0004145_abnormal_muscle_electrophysio0.91586173
75MP0001968_abnormal_touch/_nociception0.90408018
76MP0003448_altered_tumor_morphology0.89720819
77MP0002736_abnormal_nociception_after0.88817919
78MP0001542_abnormal_bone_strength0.88179063
79MP0001986_abnormal_taste_sensitivity0.87017171
80MP0004947_skin_inflammation0.86876404
81MP0005636_abnormal_mineral_homeostasis0.86868842
82MP0009765_abnormal_xenobiotic_induced0.82356656
83MP0000703_abnormal_thymus_morphology0.81389055
84MP0001764_abnormal_homeostasis0.80320683
85MP0003186_abnormal_redox_activity0.80192801
86MP0005389_reproductive_system_phenotype0.79055926
87MP0002095_abnormal_skin_pigmentation0.78323011
88MP0006292_abnormal_olfactory_placode0.77116294
89MP0000230_abnormal_systemic_arterial0.76476187
90MP0003786_premature_aging0.76354995
91MP0000858_altered_metastatic_potential0.73610227
92MP0001501_abnormal_sleep_pattern0.73327666
93MP0001970_abnormal_pain_threshold0.71990417
94MP0002693_abnormal_pancreas_physiology0.70489305
95MP0001765_abnormal_ion_homeostasis0.70360485
96MP0002733_abnormal_thermal_nociception0.70181079
97MP0009643_abnormal_urine_homeostasis0.67623870
98MP0001485_abnormal_pinna_reflex0.66242693
99MP0003137_abnormal_impulse_conducting0.65645573
100MP0001663_abnormal_digestive_system0.65364429

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.76233951
2Elevated erythrocyte sedimentation rate (HP:0003565)4.14652194
3Acute necrotizing encephalopathy (HP:0006965)4.09113648
4Mitochondrial inheritance (HP:0001427)3.98955858
5Abnormal mitochondria in muscle tissue (HP:0008316)3.84008830
6Hypoproteinemia (HP:0003075)3.82269250
7IgG deficiency (HP:0004315)3.81227406
8Abnormality of T cell number (HP:0011839)3.70838713
9T lymphocytopenia (HP:0005403)3.69461304
10Increased IgM level (HP:0003496)3.59358657
11Progressive macrocephaly (HP:0004481)3.47927870
12Hepatocellular necrosis (HP:0001404)3.40622533
133-Methylglutaconic aciduria (HP:0003535)3.38750103
14Increased CSF lactate (HP:0002490)3.33115171
15Increased intramyocellular lipid droplets (HP:0012240)3.30098034
16Acute encephalopathy (HP:0006846)3.23141645
17Stomatitis (HP:0010280)3.22990911
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22392608
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22392608
20Hepatic necrosis (HP:0002605)3.12386018
21Abnormality of the prostate (HP:0008775)3.08440845
22Severe combined immunodeficiency (HP:0004430)3.03844787
23Increased hepatocellular lipid droplets (HP:0006565)3.03802060
24Abnormality of B cell number (HP:0010975)2.96081446
25Renal Fanconi syndrome (HP:0001994)2.94653528
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88446153
27Autoimmune hemolytic anemia (HP:0001890)2.88025011
28Increased muscle lipid content (HP:0009058)2.77366733
29Lipid accumulation in hepatocytes (HP:0006561)2.75024976
30Abnormality of T cells (HP:0002843)2.68709678
31Exertional dyspnea (HP:0002875)2.68523463
32Congenital stationary night blindness (HP:0007642)2.68338132
33Cerebral edema (HP:0002181)2.67863395
34Chronic obstructive pulmonary disease (HP:0006510)2.63679802
35Obstructive lung disease (HP:0006536)2.63679802
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.62662057
37Abolished electroretinogram (ERG) (HP:0000550)2.56853059
38Abnormality of eosinophils (HP:0001879)2.56218897
39Autoimmune thrombocytopenia (HP:0001973)2.55805321
40Decreased central vision (HP:0007663)2.54141894
41Thyroiditis (HP:0100646)2.53170879
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48878273
43Eosinophilia (HP:0001880)2.47160610
44Chronic diarrhea (HP:0002028)2.46100570
45Generalized aminoaciduria (HP:0002909)2.41218236
46Encephalitis (HP:0002383)2.40534558
47Abnormality of macrophages (HP:0004311)2.36875171
48Optic disc pallor (HP:0000543)2.36037810
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33927520
50Meningitis (HP:0001287)2.32169419
51Combined immunodeficiency (HP:0005387)2.31973932
52Petechiae (HP:0000967)2.31107554
53B lymphocytopenia (HP:0010976)2.28453200
54Increased serum lactate (HP:0002151)2.25434265
55Leukocytosis (HP:0001974)2.23993311
56Lactic acidosis (HP:0003128)2.23966910
57Abnormal rod and cone electroretinograms (HP:0008323)2.19769761
58Vasculitis (HP:0002633)2.18195159
59Renal cortical cysts (HP:0000803)2.16705979
60Hemoptysis (HP:0002105)2.12078795
61Pancytopenia (HP:0001876)2.09415613
62Gangrene (HP:0100758)2.08536780
63Chest pain (HP:0100749)2.07900394
64Molar tooth sign on MRI (HP:0002419)2.07295398
65Abnormality of midbrain morphology (HP:0002418)2.07295398
66Pulmonary infiltrates (HP:0002113)2.05452780
67Attenuation of retinal blood vessels (HP:0007843)2.01824876
68Retrobulbar optic neuritis (HP:0100654)2.00172019
69Optic neuritis (HP:0100653)2.00172019
70Myositis (HP:0100614)2.00147480
71Respiratory failure (HP:0002878)2.00124313
72Abnormality of the pleura (HP:0002103)1.99463708
73Oral leukoplakia (HP:0002745)1.99210795
74Gastrointestinal infarctions (HP:0005244)1.96899720
75Pancreatic cysts (HP:0001737)1.96233715
76Acute hepatic failure (HP:0006554)1.95949262
77Chronic mucocutaneous candidiasis (HP:0002728)1.94300399
78Recurrent cutaneous fungal infections (HP:0011370)1.94300399
79Cerebral palsy (HP:0100021)1.93475879
80Agammaglobulinemia (HP:0004432)1.93258212
81Joint swelling (HP:0001386)1.93044011
82Recurrent fungal infections (HP:0002841)1.92606728
83Abnormal albumin level (HP:0012116)1.89686244
84Hypoalbuminemia (HP:0003073)1.89686244
85Type 2 muscle fiber atrophy (HP:0003554)1.88505574
86Abnormal delayed hypersensitivity skin test (HP:0002963)1.87421271
87Pulmonary fibrosis (HP:0002206)1.86886495
88Recurrent bronchitis (HP:0002837)1.86705940
89Epistaxis (HP:0000421)1.86105444
90Lethargy (HP:0001254)1.84232398
91Granulocytopenia (HP:0001913)1.82929225
92Hypergammaglobulinemia (HP:0010702)1.82646259
93Congenital, generalized hypertrichosis (HP:0004540)1.82195791
94Increased serum ferritin (HP:0003281)1.82147806
95Exercise intolerance (HP:0003546)1.81825932
96Panhypogammaglobulinemia (HP:0003139)1.77820792
97Amyotrophic lateral sclerosis (HP:0007354)1.76348435
98Abnormality of the renal cortex (HP:0011035)1.74825696
99Dicarboxylic aciduria (HP:0003215)1.73880335
100Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73880335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.08975999
2TESK24.49080966
3KDR4.15334283
4TAOK33.72639302
5BCKDK2.98508704
6MAP4K12.80009151
7MAP4K22.57093174
8TLK12.27148892
9ADRBK22.12911122
10CDK192.00371388
11MAP3K121.97170057
12ZAK1.87985233
13BMPR21.80619461
14ITK1.78242675
15SYK1.75915684
16GRK11.67746094
17TESK11.59399491
18SCYL21.59344820
19TEC1.55817168
20MST41.48273625
21LIMK11.45146379
22FES1.35202324
23MYLK1.33407320
24IKBKB1.31594562
25GRK71.31113334
26MAP3K111.30834718
27GRK61.30744755
28VRK21.27763363
29ZAP701.25997754
30CSF1R1.24058952
31BTK1.23871495
32PIM21.20359786
33RIPK41.18069702
34LYN1.16556129
35IKBKE1.10462810
36KIT1.06507753
37MUSK1.05998613
38FRK1.03945604
39LCK1.03907857
40PINK11.00183906
41NUAK10.98595230
42VRK10.98261471
43TBK10.90892090
44TIE10.90013461
45MATK0.89792208
46WNK40.89773616
47CSK0.89472498
48OXSR10.87600413
49EIF2AK30.86105869
50PRKCQ0.85208539
51BMPR1B0.81263917
52STK160.79329877
53MAP2K70.78789683
54MAPKAPK30.77519409
55JAK30.77125114
56BLK0.76631968
57DAPK10.75830966
58TNK20.75814434
59TRIM280.74809458
60RPS6KA50.71544479
61ERBB30.70894158
62CSNK1G30.68951519
63INSRR0.68016122
64WNK30.66246240
65PIK3CG0.62851345
66DAPK20.59923874
67PIM10.59177793
68HCK0.56977346
69CAMKK20.55628204
70IGF1R0.53554760
71ADRBK10.51216710
72RPS6KA40.51097732
73DYRK20.50612045
74DAPK30.49743659
75CSNK1A1L0.48443019
76MAPK130.47768033
77CSNK1G20.47245960
78ARAF0.46252945
79TRPM70.46133313
80FYN0.45941009
81PIK3CA0.44213490
82CSNK1G10.43418209
83ABL10.42825714
84PRKCE0.42176412
85PRKCA0.41500925
86OBSCN0.40211825
87GRK50.39687334
88ROCK10.36987870
89MARK30.35756811
90MAP3K50.35732414
91PRKACA0.35610246
92ABL20.35498398
93PAK10.33224753
94MAP2K60.30185778
95PTK2B0.29357540
96INSR0.28768350
97PRKCD0.28356773
98CAMK2A0.27124813
99JAK20.26468827
100SIK30.25549623

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.01752844
2Allograft rejection_Homo sapiens_hsa053303.90582243
3Autoimmune thyroid disease_Homo sapiens_hsa053203.83647044
4Asthma_Homo sapiens_hsa053103.80470963
5Primary immunodeficiency_Homo sapiens_hsa053403.45722865
6Type I diabetes mellitus_Homo sapiens_hsa049403.24397139
7Proteasome_Homo sapiens_hsa030503.22070090
8Oxidative phosphorylation_Homo sapiens_hsa001903.12247911
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.99855141
10Antigen processing and presentation_Homo sapiens_hsa046122.83473178
11Parkinsons disease_Homo sapiens_hsa050122.52558247
12Rheumatoid arthritis_Homo sapiens_hsa053232.47493955
13Hematopoietic cell lineage_Homo sapiens_hsa046402.27219029
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06040805
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01747781
16Staphylococcus aureus infection_Homo sapiens_hsa051501.88409555
17Viral myocarditis_Homo sapiens_hsa054161.84909138
18Alzheimers disease_Homo sapiens_hsa050101.61402204
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59432826
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52436801
21Protein export_Homo sapiens_hsa030601.40670234
22Ribosome_Homo sapiens_hsa030101.38630074
23Phototransduction_Homo sapiens_hsa047441.36657870
24Leishmaniasis_Homo sapiens_hsa051401.36029610
25Huntingtons disease_Homo sapiens_hsa050161.34326763
26Cardiac muscle contraction_Homo sapiens_hsa042601.33662622
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24223779
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22057740
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18119539
30Systemic lupus erythematosus_Homo sapiens_hsa053221.13069007
31T cell receptor signaling pathway_Homo sapiens_hsa046601.10895226
32Collecting duct acid secretion_Homo sapiens_hsa049661.09699338
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06903122
34RNA polymerase_Homo sapiens_hsa030201.02927222
35Nitrogen metabolism_Homo sapiens_hsa009101.01206616
36Salmonella infection_Homo sapiens_hsa051320.98642684
37NF-kappa B signaling pathway_Homo sapiens_hsa040640.97291268
38Malaria_Homo sapiens_hsa051440.97141183
39NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89866907
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88065933
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86503224
42Linoleic acid metabolism_Homo sapiens_hsa005910.86383258
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78184769
44Phagosome_Homo sapiens_hsa041450.76034452
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75479802
46Tuberculosis_Homo sapiens_hsa051520.73977411
47Shigellosis_Homo sapiens_hsa051310.72135491
48Herpes simplex infection_Homo sapiens_hsa051680.71658831
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68870508
50Olfactory transduction_Homo sapiens_hsa047400.68755305
51Peroxisome_Homo sapiens_hsa041460.68228077
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66079789
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65714575
54Regulation of autophagy_Homo sapiens_hsa041400.65144590
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64073884
56Measles_Homo sapiens_hsa051620.63527851
57Caffeine metabolism_Homo sapiens_hsa002320.63172154
58Arachidonic acid metabolism_Homo sapiens_hsa005900.62017921
59Legionellosis_Homo sapiens_hsa051340.57581827
60Pertussis_Homo sapiens_hsa051330.57433795
61Butanoate metabolism_Homo sapiens_hsa006500.54659653
62Chemical carcinogenesis_Homo sapiens_hsa052040.52145478
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.44951576
64Ether lipid metabolism_Homo sapiens_hsa005650.44281490
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43382512
66Pyrimidine metabolism_Homo sapiens_hsa002400.43325876
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42960336
68Influenza A_Homo sapiens_hsa051640.41011739
69RNA degradation_Homo sapiens_hsa030180.39759036
70Sulfur metabolism_Homo sapiens_hsa009200.38984478
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38577524
72Toxoplasmosis_Homo sapiens_hsa051450.38566542
73African trypanosomiasis_Homo sapiens_hsa051430.38387880
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37967383
75Chemokine signaling pathway_Homo sapiens_hsa040620.36671085
76Homologous recombination_Homo sapiens_hsa034400.36602207
77Tryptophan metabolism_Homo sapiens_hsa003800.34172777
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.33668291
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33441073
80Purine metabolism_Homo sapiens_hsa002300.33223374
81Lysosome_Homo sapiens_hsa041420.32929319
82Platelet activation_Homo sapiens_hsa046110.31856309
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.31537612
84Epstein-Barr virus infection_Homo sapiens_hsa051690.31446890
85Mineral absorption_Homo sapiens_hsa049780.29883235
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.29385253
87Osteoclast differentiation_Homo sapiens_hsa043800.28545461
88Retinol metabolism_Homo sapiens_hsa008300.28542403
89Propanoate metabolism_Homo sapiens_hsa006400.28140395
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27372170
91Morphine addiction_Homo sapiens_hsa050320.25684350
92Salivary secretion_Homo sapiens_hsa049700.25556368
93Metabolic pathways_Homo sapiens_hsa011000.25042438
94Fanconi anemia pathway_Homo sapiens_hsa034600.24562852
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23583504
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.21879024
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20761027
98Nicotine addiction_Homo sapiens_hsa050330.18036506
99GABAergic synapse_Homo sapiens_hsa047270.15914670
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15436480

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