FTL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)5.02586809
2negative regulation of interleukin-12 production (GO:0032695)4.98319026
3oligosaccharide catabolic process (GO:0009313)4.94611927
4response to peptidoglycan (GO:0032494)4.68063550
5regulation of mononuclear cell migration (GO:0071675)4.58455947
6glycolipid catabolic process (GO:0019377)4.52601749
7neutrophil activation involved in immune response (GO:0002283)4.45377092
8amino sugar catabolic process (GO:0046348)4.33530137
9ceramide catabolic process (GO:0046514)4.04044935
10cellular response to thyroid hormone stimulus (GO:0097067)3.99988948
11regulation of cytokine secretion involved in immune response (GO:0002739)3.96964611
12regulation of vitamin D biosynthetic process (GO:0060556)3.91292628
13lipopolysaccharide-mediated signaling pathway (GO:0031663)3.81011202
14immunoglobulin mediated immune response (GO:0016064)3.80950012
15negative regulation of nitric oxide biosynthetic process (GO:0045019)3.75066901
16macrophage activation involved in immune response (GO:0002281)3.70856693
17positive regulation of chemokine biosynthetic process (GO:0045080)3.70146586
18membrane lipid catabolic process (GO:0046466)3.57383352
19sphingolipid catabolic process (GO:0030149)3.46205371
20regulation of podosome assembly (GO:0071801)3.43276857
21regulation of cholesterol storage (GO:0010885)3.40894329
22T-helper 1 type immune response (GO:0042088)3.40057963
23negative regulation of cytokine production involved in immune response (GO:0002719)3.38765100
24response to thyroid hormone (GO:0097066)3.36953050
25myeloid dendritic cell differentiation (GO:0043011)3.35859518
26positive regulation of monocyte chemotaxis (GO:0090026)3.34959193
27monocyte chemotaxis (GO:0002548)3.34370951
28regulation of chemokine biosynthetic process (GO:0045073)3.31879684
29regulation of vitamin metabolic process (GO:0030656)3.27376131
30positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.25798756
31N-acetylneuraminate metabolic process (GO:0006054)3.25582017
32negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.19901658
33granulocyte activation (GO:0036230)3.18818371
34NIK/NF-kappaB signaling (GO:0038061)3.16257379
35regulation of macrophage chemotaxis (GO:0010758)3.12856703
36positive regulation by symbiont of host defense response (GO:0052509)3.10892081
37modulation by symbiont of host defense response (GO:0052031)3.10892081
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10892081
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10892081
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.10892081
41modulation by symbiont of host immune response (GO:0052553)3.10892081
42adhesion of symbiont to host cell (GO:0044650)3.10630302
43virion attachment to host cell (GO:0019062)3.10630302
44negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.09883435
45positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.05632334
46positive regulation of gamma-delta T cell activation (GO:0046645)3.05404492
47regulation of mast cell degranulation (GO:0043304)3.05314537
48positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.02176833
49interferon-gamma-mediated signaling pathway (GO:0060333)3.01777107
50regulation of T-helper 1 cell differentiation (GO:0045625)2.99275454
51regulation of membrane protein ectodomain proteolysis (GO:0051043)2.99173281
52regulation of interferon-alpha production (GO:0032647)2.98619873
53detection of molecule of bacterial origin (GO:0032490)2.98021389
54myeloid dendritic cell activation (GO:0001773)2.97389304
55negative regulation of myeloid cell apoptotic process (GO:0033033)2.95619361
56eosinophil chemotaxis (GO:0048245)2.94085369
57branching involved in labyrinthine layer morphogenesis (GO:0060670)2.91422002
58positive regulation of heat generation (GO:0031652)2.91087595
59positive regulation of antigen processing and presentation (GO:0002579)2.87877110
60regulation of chronic inflammatory response (GO:0002676)2.86301617
61phagosome maturation (GO:0090382)2.85446451
62positive regulation of leukocyte degranulation (GO:0043302)2.85058149
63keratan sulfate catabolic process (GO:0042340)2.85004539
64dendritic cell differentiation (GO:0097028)2.84471506
65cellular response to type I interferon (GO:0071357)2.84347099
66type I interferon signaling pathway (GO:0060337)2.84347099
67positive regulation of mast cell degranulation (GO:0043306)2.81110731
68positive regulation of mast cell activation involved in immune response (GO:0033008)2.81110731
69B cell mediated immunity (GO:0019724)2.80611565
70fat-soluble vitamin biosynthetic process (GO:0042362)2.79724995
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.79134571
72response to type I interferon (GO:0034340)2.78430232
73regulation of mast cell activation involved in immune response (GO:0033006)2.77401740
74myeloid cell activation involved in immune response (GO:0002275)2.76947073
75regulation of monocyte chemotaxis (GO:0090025)2.76333938
76regulation of antigen processing and presentation (GO:0002577)2.76266884
77regulation of inflammatory response to antigenic stimulus (GO:0002861)2.76102623
78response to protozoan (GO:0001562)2.75940052
79cellular response to lipopolysaccharide (GO:0071222)2.75370776
80cellular response to arsenic-containing substance (GO:0071243)2.73593599
81adhesion of symbiont to host (GO:0044406)2.73348138
82regulation of interferon-beta biosynthetic process (GO:0045357)2.72076368
83negative regulation of lipid storage (GO:0010888)2.71963045
84regulation of fever generation (GO:0031620)2.70089895
85positive regulation of mast cell activation (GO:0033005)2.70065604
86regulation of interleukin-8 biosynthetic process (GO:0045414)2.69804262
87positive regulation of cellular amide metabolic process (GO:0034250)2.69751043
88negative regulation of production of molecular mediator of immune response (GO:0002701)2.69244186
89defense response to protozoan (GO:0042832)2.68611481
90regulation of superoxide anion generation (GO:0032928)2.68399865
91cellular response to molecule of bacterial origin (GO:0071219)2.68287734
92eosinophil migration (GO:0072677)2.66964193
93positive regulation of NF-kappaB import into nucleus (GO:0042346)2.66775240
94regulation of leukocyte degranulation (GO:0043300)2.66358412
95positive regulation of interleukin-6 production (GO:0032755)2.66215033
96low-density lipoprotein particle clearance (GO:0034383)2.66170347
97macrophage activation (GO:0042116)2.65878729
98pinocytosis (GO:0006907)2.65488152
99regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.63419806
100regulation of interleukin-12 production (GO:0032655)2.61281767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.41107733
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.20780125
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.45567411
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human4.30895148
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.81533568
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.48214453
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32532828
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.20490755
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.15907919
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.73624420
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71249706
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66862047
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63071369
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35348960
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17833732
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14928031
17* SPI1_23547873_ChIP-Seq_NB4_Human2.12343000
18* SPI1_23127762_ChIP-Seq_K562_Human2.07728152
19* VDR_24787735_ChIP-Seq_THP-1_Human2.02335749
20* VDR_24763502_ChIP-Seq_THP-1_Human2.00541345
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97633056
22BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96099125
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89696880
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.84382386
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81666940
26VDR_21846776_ChIP-Seq_THP-1_Human1.81150974
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78227934
28TFEB_21752829_ChIP-Seq_HELA_Human1.77201989
29CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.76830917
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74505418
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74372895
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72203692
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67223939
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64438465
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64345016
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60765130
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55211856
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.53998038
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53241860
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50765778
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49205359
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.47434761
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47113078
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46504260
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46451196
46SCL_19346495_ChIP-Seq_HPC-7_Human1.45769996
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.44360844
48PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42451756
49SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38904458
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37354047
51LXR_22292898_ChIP-Seq_THP-1_Human1.36218556
52* ELK3_25401928_ChIP-Seq_HUVEC_Human1.35920148
53PU_27001747_Chip-Seq_BMDM_Mouse1.35232971
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34866230
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33567675
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32036303
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31778207
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31638916
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31517099
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29431049
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29242081
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26473616
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24782161
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24485735
65STAT1_20625510_ChIP-Seq_HELA_Human1.22483166
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.21840065
67GATA1_19941826_ChIP-Seq_K562_Human1.17503145
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16991651
69* MAF_26560356_Chip-Seq_TH1_Human1.16725020
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15643985
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.10628383
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.10058086
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08652361
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06847936
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05208905
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04254878
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00798845
78GATA1_22025678_ChIP-Seq_K562_Human0.99237198
79MYB_26560356_Chip-Seq_TH2_Human0.99198422
80SMAD_19615063_ChIP-ChIP_OVARY_Human0.97332325
81RUNX_20019798_ChIP-Seq_JUKART_Human0.96272078
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95723757
83BCL6_27268052_Chip-Seq_Bcells_Human0.95033980
84ELF1_20517297_ChIP-Seq_JURKAT_Human0.94896151
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93601862
86BCOR_27268052_Chip-Seq_Bcells_Human0.93250315
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90764220
88* UTX_26944678_Chip-Seq_JUKART_Human0.89424619
89STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88091658
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86682022
91ESR2_21235772_ChIP-Seq_MCF-7_Human0.86128397
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86017777
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84662275
94* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83760372
95* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82969194
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82290200
97* MAF_26560356_Chip-Seq_TH2_Human0.82069761
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81351978
99MYB_26560356_Chip-Seq_TH1_Human0.80322668
100GATA3_26560356_Chip-Seq_TH2_Human0.79257687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.71082615
2MP0003303_peritoneal_inflammation4.21572376
3MP0009840_abnormal_foam_cell3.83689530
4MP0006082_CNS_inflammation3.73811913
5MP0002139_abnormal_hepatobiliary_system3.59034799
6MP0002148_abnormal_hypersensitivity_rea3.17492813
7MP0003172_abnormal_lysosome_physiology3.10135834
8MP0003436_decreased_susceptibility_to2.93924493
9MP0003724_increased_susceptibility_to2.91032283
10MP0009785_altered_susceptibility_to2.83265237
11MP0003191_abnormal_cellular_cholesterol2.63507395
12MP0002419_abnormal_innate_immunity2.59406969
13MP0001835_abnormal_antigen_presentation2.56887286
14MP0000604_amyloidosis2.48537244
15MP0000343_altered_response_to2.32513845
16MP0003806_abnormal_nucleotide_metabolis2.31827008
17MP0004510_myositis2.27507630
18MP0005000_abnormal_immune_tolerance2.26058544
19MP0005387_immune_system_phenotype2.25388313
20MP0001790_abnormal_immune_system2.25388313
21MP0005671_abnormal_response_to2.24535735
22MP0005025_abnormal_response_to2.22362222
23MP0003075_altered_response_to2.20222900
24MP0003300_gastrointestinal_ulcer2.12293270
25MP0009764_decreased_sensitivity_to2.03032038
26MP0001533_abnormal_skeleton_physiology1.93579653
27MP0002254_reproductive_system_inflammat1.93095623
28MP0002452_abnormal_antigen_presenting1.92125797
29MP0005451_abnormal_body_composition1.87031496
30MP0006054_spinal_hemorrhage1.86685332
31MP0001853_heart_inflammation1.86206669
32MP0002723_abnormal_immune_serum1.80899161
33MP0000685_abnormal_immune_system1.74273205
34MP0001845_abnormal_inflammatory_respons1.67049243
35MP0001800_abnormal_humoral_immune1.63323746
36MP0003690_abnormal_glial_cell1.62343240
37MP0001545_abnormal_hematopoietic_system1.62036356
38MP0005397_hematopoietic_system_phenotyp1.62036356
39MP0008469_abnormal_protein_level1.61496396
40MP0009278_abnormal_bone_marrow1.60619706
41MP0002998_abnormal_bone_remodeling1.60250363
42MP0005464_abnormal_platelet_physiology1.57465102
43MP0002420_abnormal_adaptive_immunity1.51976061
44MP0008004_abnormal_stomach_pH1.51834443
45MP0001819_abnormal_immune_cell1.51772529
46MP0002405_respiratory_system_inflammati1.51114704
47MP0005310_abnormal_salivary_gland1.49768568
48MP0005167_abnormal_blood-brain_barrier1.45047806
49MP0003195_calcinosis1.42806470
50MP0003448_altered_tumor_morphology1.42305160
51MP0005365_abnormal_bile_salt1.40969702
52MP0004947_skin_inflammation1.39160076
53MP0009333_abnormal_splenocyte_physiolog1.31957630
54MP0010155_abnormal_intestine_physiology1.31875717
55MP0003656_abnormal_erythrocyte_physiolo1.28522022
56MP0003453_abnormal_keratinocyte_physiol1.27068812
57MP0000858_altered_metastatic_potential1.26895453
58MP0005166_decreased_susceptibility_to1.26862191
59MP0003329_amyloid_beta_deposits1.18951237
60MP0003186_abnormal_redox_activity1.15083408
61MP0005164_abnormal_response_to1.14174178
62MP0001542_abnormal_bone_strength1.09819420
63MP0000920_abnormal_myelination1.07780619
64MP0008260_abnormal_autophagy1.07297586
65MP0002138_abnormal_hepatobiliary_system1.04650836
66MP0000716_abnormal_immune_system1.01331540
67MP0005165_increased_susceptibility_to0.98739206
68MP0009763_increased_sensitivity_to0.95275500
69MP0004883_abnormal_blood_vessel0.88158701
70MP0005390_skeleton_phenotype0.87913331
71MP0002090_abnormal_vision0.85996176
72MP0002332_abnormal_exercise_endurance0.85365719
73MP0000689_abnormal_spleen_morphology0.81370008
74MP0003828_pulmonary_edema0.81175502
75MP0005257_abnormal_intraocular_pressure0.79910606
76MP0002429_abnormal_blood_cell0.78495511
77MP0003183_abnormal_peptide_metabolism0.76018091
78MP0003795_abnormal_bone_structure0.75793733
79MP0002398_abnormal_bone_marrow0.74920655
80MP0005319_abnormal_enzyme/_coenzyme0.73811217
81MP0005023_abnormal_wound_healing0.73700001
82MP0000609_abnormal_liver_physiology0.72830189
83MP0005647_abnormal_sex_gland0.72129957
84MP0004019_abnormal_vitamin_homeostasis0.71248357
85MP0000371_diluted_coat_color0.69972211
86MP0001663_abnormal_digestive_system0.69247536
87MP0009765_abnormal_xenobiotic_induced0.67822459
88MP0010307_abnormal_tumor_latency0.67629663
89MP0002933_joint_inflammation0.67079758
90MP0003279_aneurysm0.65711200
91MP0002722_abnormal_immune_system0.65049109
92MP0003634_abnormal_glial_cell0.63988887
93MP0008874_decreased_physiological_sensi0.63191978
94MP0005584_abnormal_enzyme/coenzyme_acti0.62936293
95MP0001764_abnormal_homeostasis0.60506543
96MP0003091_abnormal_cell_migration0.60434815
97MP0000249_abnormal_blood_vessel0.58233860
98MP0002877_abnormal_melanocyte_morpholog0.58088948
99MP0002277_abnormal_respiratory_mucosa0.57116464
100MP0002837_dystrophic_cardiac_calcinosis0.56168762

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)8.83818663
2Abnormality of glycosphingolipid metabolism (HP:0004343)8.83818663
3Abnormality of glycolipid metabolism (HP:0010969)8.83818663
4Vacuolated lymphocytes (HP:0001922)6.22047327
5Systemic lupus erythematosus (HP:0002725)5.57453269
6Increased cerebral lipofuscin (HP:0011813)5.57031250
7Dysostosis multiplex (HP:0000943)5.05786056
8Abnormality of macrophages (HP:0004311)4.96794102
9Loss of speech (HP:0002371)4.93414615
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.55236236
11Abnormality of mucopolysaccharide metabolism (HP:0011020)4.00551508
12Abnormality of polysaccharide metabolism (HP:0011012)4.00551508
13Abnormality of glycosaminoglycan metabolism (HP:0004371)4.00551508
14Mucopolysacchariduria (HP:0008155)3.77760639
15Urinary glycosaminoglycan excretion (HP:0003541)3.77760639
16Recurrent abscess formation (HP:0002722)3.76646740
17Recurrent bacterial skin infections (HP:0005406)3.75540315
18* Disinhibition (HP:0000734)3.61556611
19Glomerulonephritis (HP:0000099)3.56689831
20Neurofibrillary tangles (HP:0002185)3.47440232
21Axonal loss (HP:0003447)3.46665062
22Eczematoid dermatitis (HP:0000976)3.45818594
23Autoimmune thrombocytopenia (HP:0001973)3.35328468
24Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.26360173
25Stomatitis (HP:0010280)3.21154991
26Orchitis (HP:0100796)3.16999771
27Recurrent gram-negative bacterial infections (HP:0005420)3.14301947
28Purpura (HP:0000979)3.05938706
29Abnormality of the vasculature of the conjunctiva (HP:0008054)3.00171688
30Optic neuritis (HP:0100653)2.98792254
31Retrobulbar optic neuritis (HP:0100654)2.98792254
32Diminished motivation (HP:0000745)2.96681214
33Apathy (HP:0000741)2.96631516
34Myositis (HP:0100614)2.96419750
35Mediastinal lymphadenopathy (HP:0100721)2.96366127
36Myocardial infarction (HP:0001658)2.95883133
37Complement deficiency (HP:0004431)2.95799138
38Progressive neurologic deterioration (HP:0002344)2.87091972
39Agnosia (HP:0010524)2.83412265
40* Mutism (HP:0002300)2.73874483
41Hepatosplenomegaly (HP:0001433)2.73199299
42Petechiae (HP:0000967)2.71191158
43Upper motor neuron abnormality (HP:0002127)2.68206700
44Prolonged neonatal jaundice (HP:0006579)2.58847103
45Neuronal loss in central nervous system (HP:0002529)2.57019426
46Metaphyseal irregularity (HP:0003025)2.54274999
47Amyloidosis (HP:0011034)2.52593776
48Obstructive lung disease (HP:0006536)2.51952769
49Chronic obstructive pulmonary disease (HP:0006510)2.51952769
50Hematochezia (HP:0002573)2.43796520
51Retinal atrophy (HP:0001105)2.43624797
52Abnormality of complement system (HP:0005339)2.37394554
53Cerebral inclusion bodies (HP:0100314)2.36625393
54Nausea (HP:0002018)2.34063673
55Personality changes (HP:0000751)2.33136366
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30374332
57Pulmonary infiltrates (HP:0002113)2.24130014
58Vertebral compression fractures (HP:0002953)2.19320323
59Polyneuropathy (HP:0001271)2.13693466
60Cardiomegaly (HP:0001640)2.10392359
61Increased CSF protein (HP:0002922)2.06350564
62Recurrent skin infections (HP:0001581)2.06017225
63Basal ganglia calcification (HP:0002135)2.05651690
64Pathologic fracture (HP:0002756)2.03341794
65* Dementia (HP:0000726)2.01070366
66* Increased serum ferritin (HP:0003281)1.99389333
67Malnutrition (HP:0004395)1.95776100
68Peripheral demyelination (HP:0011096)1.94210930
69Xanthomatosis (HP:0000991)1.93423457
70Keratoconjunctivitis sicca (HP:0001097)1.93405442
71Supranuclear gaze palsy (HP:0000605)1.89288976
72Bone pain (HP:0002653)1.88476325
73Asymmetric septal hypertrophy (HP:0001670)1.88239227
74Conjunctival telangiectasia (HP:0000524)1.88067132
75Increased IgM level (HP:0003496)1.87911886
76Gingivitis (HP:0000230)1.86946456
77Interstitial pulmonary disease (HP:0006530)1.86912783
78Beaking of vertebral bodies (HP:0004568)1.86001362
79Global brain atrophy (HP:0002283)1.84584260
80Hemoptysis (HP:0002105)1.84163062
81Spontaneous hematomas (HP:0007420)1.84120572
82Nephritis (HP:0000123)1.80800596
83Abnormality of the periventricular white matter (HP:0002518)1.80272817
84J-shaped sella turcica (HP:0002680)1.79437653
85Multiple enchondromatosis (HP:0005701)1.78434097
86Vasculitis (HP:0002633)1.78365237
87Memory impairment (HP:0002354)1.77068654
88Keratoconjunctivitis (HP:0001096)1.75158487
89Thoracic kyphosis (HP:0002942)1.72085410
90Recurrent fungal infections (HP:0002841)1.71630063
91* Inappropriate behavior (HP:0000719)1.71077117
92Poor head control (HP:0002421)1.70648709
93Urticaria (HP:0001025)1.70037163
94Generalized aminoaciduria (HP:0002909)1.68045211
95* Nuclear cataract (HP:0100018)1.67580964
96Elevated erythrocyte sedimentation rate (HP:0003565)1.66850700
97Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66726596
98Tetraparesis (HP:0002273)1.66204593
99Splenomegaly (HP:0001744)1.65878810
100Albinism (HP:0001022)1.65226678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.68340484
2NME24.38482145
3GRK73.55098417
4BLK2.87163578
5TGFBR22.75932381
6MAP3K142.66290458
7DDR22.66117012
8TAOK22.66108685
9TBK12.64489764
10MAP3K112.42890875
11TYK22.38885432
12ERN12.28615914
13RIPK42.28160155
14MAP3K32.18183357
15MATK2.16413219
16PIM22.15714424
17ACVR1B2.05951935
18FGR2.03690679
19IKBKB1.94383478
20MAP2K31.83536029
21ABL21.82387354
22IRAK41.82248069
23CSK1.77172205
24TAOK11.71511611
25MOS1.65777361
26MAP4K11.64592458
27ADRBK21.60847982
28RIPK11.47380105
29TESK11.44420831
30PRPF4B1.40245977
31IKBKE1.38995578
32SIK31.36252624
33ZAP701.30624156
34JAK31.28585011
35BMPR21.25366411
36TESK21.22850777
37CDC42BPA1.21254691
38TXK1.20104429
39CSF1R1.15628361
40MAP3K11.13521967
41MAP3K131.11403528
42LYN1.03691939
43PDK21.03050898
44MAP3K51.00353661
45CAMKK20.99572731
46LIMK10.92834580
47SYK0.92326059
48ARAF0.92211695
49CHUK0.91375045
50PAK40.86851493
51MAP2K60.85487488
52MARK30.81872019
53JAK10.80612998
54MAP3K120.78096814
55IRAK20.75634779
56JAK20.74419272
57FES0.73183594
58KIT0.71435238
59LCK0.70322999
60STK100.69663372
61PBK0.65892758
62CAMK1D0.63544022
63HCK0.63213298
64CLK10.61203327
65DAPK20.54618226
66IRAK10.54156901
67NEK90.52336736
68DAPK30.51934304
69BMX0.49954147
70BCKDK0.49196175
71TNK20.49106609
72BTK0.47463986
73TAOK30.45988325
74CDK60.45974334
75PIM10.45170923
76PRKG20.45090747
77TGFBR10.44521416
78ABL10.44224847
79PDPK10.42197504
80PDGFRA0.36447727
81MAPK40.36033207
82PDK10.33067516
83PRKCD0.32241849
84MAP3K80.31636311
85MAPKAPK20.31426279
86INSR0.27559541
87MST40.26402481
88ERBB40.25777479
89PAK10.25658877
90RPS6KL10.24924900
91RPS6KC10.24924900
92EGFR0.24416376
93GSK3A0.22614806
94KSR10.20906846
95LATS20.20214438
96MYLK0.20095606
97TYRO30.19543717
98FYN0.17479015
99ITK0.17079812
100KDR0.16482865

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.54907274
2Lysosome_Homo sapiens_hsa041423.83424540
3Staphylococcus aureus infection_Homo sapiens_hsa051503.28510094
4Rheumatoid arthritis_Homo sapiens_hsa053233.04292873
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.88265508
6Osteoclast differentiation_Homo sapiens_hsa043802.59044950
7Asthma_Homo sapiens_hsa053102.53593876
8Allograft rejection_Homo sapiens_hsa053302.43759848
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.36171437
10Leishmaniasis_Homo sapiens_hsa051402.35872293
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12002433
12Tuberculosis_Homo sapiens_hsa051522.10954941
13Pertussis_Homo sapiens_hsa051332.09481456
14Malaria_Homo sapiens_hsa051442.09312748
15Graft-versus-host disease_Homo sapiens_hsa053322.04796766
16Autoimmune thyroid disease_Homo sapiens_hsa053201.95041173
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93899855
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.92234046
19Legionellosis_Homo sapiens_hsa051341.87650577
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.86415773
21Phagosome_Homo sapiens_hsa041451.83883761
22Collecting duct acid secretion_Homo sapiens_hsa049661.79964202
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75387686
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69385492
25Antigen processing and presentation_Homo sapiens_hsa046121.68751465
26Type I diabetes mellitus_Homo sapiens_hsa049401.66273730
27TNF signaling pathway_Homo sapiens_hsa046681.65102346
28Salmonella infection_Homo sapiens_hsa051321.59558203
29Complement and coagulation cascades_Homo sapiens_hsa046101.49653515
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47374093
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44267908
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38963807
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31962513
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31757711
35Toxoplasmosis_Homo sapiens_hsa051451.31265772
36Hematopoietic cell lineage_Homo sapiens_hsa046401.29476697
37African trypanosomiasis_Homo sapiens_hsa051431.27067442
38Influenza A_Homo sapiens_hsa051641.21785670
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20106955
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18751355
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17541419
42Prion diseases_Homo sapiens_hsa050201.17323314
43Vibrio cholerae infection_Homo sapiens_hsa051101.14718217
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.13206939
45Sulfur metabolism_Homo sapiens_hsa009201.06105169
46Sphingolipid metabolism_Homo sapiens_hsa006001.03240321
47Viral myocarditis_Homo sapiens_hsa054160.99732088
48Shigellosis_Homo sapiens_hsa051310.96137225
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90478320
50Herpes simplex infection_Homo sapiens_hsa051680.90184113
51Galactose metabolism_Homo sapiens_hsa000520.90153320
52Glutathione metabolism_Homo sapiens_hsa004800.80788279
53Chemokine signaling pathway_Homo sapiens_hsa040620.79250687
54Measles_Homo sapiens_hsa051620.78995854
55B cell receptor signaling pathway_Homo sapiens_hsa046620.77200425
56Hepatitis C_Homo sapiens_hsa051600.75072836
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.72607118
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72043966
59PPAR signaling pathway_Homo sapiens_hsa033200.71928732
60Apoptosis_Homo sapiens_hsa042100.69896836
61Amoebiasis_Homo sapiens_hsa051460.67667654
62Bladder cancer_Homo sapiens_hsa052190.62897943
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61788029
64Fructose and mannose metabolism_Homo sapiens_hsa000510.60612061
65Hepatitis B_Homo sapiens_hsa051610.57580620
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51536416
67Primary immunodeficiency_Homo sapiens_hsa053400.48504407
68Epstein-Barr virus infection_Homo sapiens_hsa051690.48056217
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.46242606
70Pentose phosphate pathway_Homo sapiens_hsa000300.45929965
71Acute myeloid leukemia_Homo sapiens_hsa052210.44909422
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44417758
73* Mineral absorption_Homo sapiens_hsa049780.41542277
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.41485509
75Tryptophan metabolism_Homo sapiens_hsa003800.41435467
76Synaptic vesicle cycle_Homo sapiens_hsa047210.39637988
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38891810
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37406181
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35443045
80T cell receptor signaling pathway_Homo sapiens_hsa046600.32574640
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.31429852
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30719094
83Endocytosis_Homo sapiens_hsa041440.30103321
84Renin-angiotensin system_Homo sapiens_hsa046140.28830171
85HIF-1 signaling pathway_Homo sapiens_hsa040660.27905330
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.27546614
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23443536
88Oxidative phosphorylation_Homo sapiens_hsa001900.21830149
89Proteasome_Homo sapiens_hsa030500.20603374
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16351538
91Prolactin signaling pathway_Homo sapiens_hsa049170.15755632
92VEGF signaling pathway_Homo sapiens_hsa043700.15196455
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13831792
94Arachidonic acid metabolism_Homo sapiens_hsa005900.12257851
95HTLV-I infection_Homo sapiens_hsa051660.11558403
96Type II diabetes mellitus_Homo sapiens_hsa049300.10907544
97Systemic lupus erythematosus_Homo sapiens_hsa053220.10649160
98Fatty acid elongation_Homo sapiens_hsa000620.10524131
99Platelet activation_Homo sapiens_hsa046110.10284921
100Chemical carcinogenesis_Homo sapiens_hsa052040.08051900

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