FTLP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA catabolic process (GO:0016075)6.34898066
2cellular response to ATP (GO:0071318)5.94641443
3resolution of meiotic recombination intermediates (GO:0000712)5.57265415
4DNA deamination (GO:0045006)5.21553561
5negative regulation of execution phase of apoptosis (GO:1900118)4.86097830
6UDP-N-acetylglucosamine metabolic process (GO:0006047)4.76112078
7protein neddylation (GO:0045116)4.70668935
8axoneme assembly (GO:0035082)4.13274375
9protein K63-linked deubiquitination (GO:0070536)4.06403545
10maturation of 5.8S rRNA (GO:0000460)4.03239827
11cellular ketone body metabolic process (GO:0046950)3.89855402
12ncRNA catabolic process (GO:0034661)3.89537692
13respiratory chain complex IV assembly (GO:0008535)3.82113564
14dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.74596715
15T cell migration (GO:0072678)3.68549277
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.64997382
17mannosylation (GO:0097502)3.59675139
18negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.58853456
19xenobiotic catabolic process (GO:0042178)3.57760112
20cytidine metabolic process (GO:0046087)3.57523119
21cytidine catabolic process (GO:0006216)3.57523119
22cytidine deamination (GO:0009972)3.57523119
23positive regulation of T-helper 1 type immune response (GO:0002827)3.48784709
24negative regulation of telomere maintenance (GO:0032205)3.46024517
25positive regulation of T cell mediated cytotoxicity (GO:0001916)3.44675025
26nucleotide transmembrane transport (GO:1901679)3.43180463
27ketone body metabolic process (GO:1902224)3.41458146
28negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.40997884
29maturation of SSU-rRNA (GO:0030490)3.40507888
30cytochrome complex assembly (GO:0017004)3.33956330
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.30972232
32L-phenylalanine catabolic process (GO:0006559)3.30972232
33lymphocyte migration (GO:0072676)3.30136147
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26348920
35negative regulation of interleukin-12 production (GO:0032695)3.22026717
36negative regulation of T cell mediated immunity (GO:0002710)3.18966692
37dosage compensation (GO:0007549)3.18852286
38positive regulation of protein homooligomerization (GO:0032464)3.18379151
39positive regulation of T cell cytokine production (GO:0002726)3.14792302
40histone mRNA catabolic process (GO:0071044)3.13811130
41pyrimidine ribonucleoside catabolic process (GO:0046133)3.11885485
42adenosine metabolic process (GO:0046085)3.07786551
43thrombin receptor signaling pathway (GO:0070493)3.05674351
44regulation of T-helper 1 type immune response (GO:0002825)3.04472916
45positive regulation of interleukin-10 production (GO:0032733)2.99586309
46valine metabolic process (GO:0006573)2.98963831
47piRNA metabolic process (GO:0034587)2.91418288
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90848497
49platelet dense granule organization (GO:0060155)2.90522050
50intracellular pH reduction (GO:0051452)2.90331246
51fucosylation (GO:0036065)2.83226718
52regulation of T cell mediated cytotoxicity (GO:0001914)2.82966088
53UV protection (GO:0009650)2.82740880
54regulation of histone H3-K27 methylation (GO:0061085)2.80540232
55interferon-gamma production (GO:0032609)2.80225924
56epithelial cilium movement (GO:0003351)2.78184291
57protein prenylation (GO:0018342)2.75771510
58prenylation (GO:0097354)2.75771510
59DNA excision (GO:0044349)2.73622496
60nucleotide-excision repair, DNA damage removal (GO:0000718)2.73622496
61positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.71657619
62preassembly of GPI anchor in ER membrane (GO:0016254)2.68805720
63aromatic amino acid family catabolic process (GO:0009074)2.68731303
64sequestering of metal ion (GO:0051238)2.67763484
65isoprenoid biosynthetic process (GO:0008299)2.66180671
66toxin metabolic process (GO:0009404)2.65893852
67negative regulation of interleukin-2 production (GO:0032703)2.64322338
68N-acetylneuraminate metabolic process (GO:0006054)2.63627228
69L-ascorbic acid metabolic process (GO:0019852)2.63379200
70negative regulation of cAMP-mediated signaling (GO:0043951)2.63039093
71serotonin receptor signaling pathway (GO:0007210)2.62558196
72cofactor catabolic process (GO:0051187)2.62011160
73erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.61255976
74L-phenylalanine metabolic process (GO:0006558)2.61255976
75histone mRNA metabolic process (GO:0008334)2.61180316
76response to xenobiotic stimulus (GO:0009410)2.60857985
77GDP-mannose metabolic process (GO:0019673)2.60606946
78cellular response to interferon-alpha (GO:0035457)2.59214955
79positive regulation of alpha-beta T cell proliferation (GO:0046641)2.58608263
80kynurenine metabolic process (GO:0070189)2.58242743
81N-acetylglucosamine metabolic process (GO:0006044)2.55602947
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54046195
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54046195
84glycerophospholipid catabolic process (GO:0046475)2.53667738
85photoreceptor cell maintenance (GO:0045494)2.53114716
86branching involved in labyrinthine layer morphogenesis (GO:0060670)2.52040794
87regulation of hypersensitivity (GO:0002883)2.51137587
88T-helper cell differentiation (GO:0042093)2.46882690
89CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.46882690
90lymphocyte chemotaxis (GO:0048247)2.46877053
91GPI anchor metabolic process (GO:0006505)2.46849943
92detection of light stimulus involved in sensory perception (GO:0050962)2.46101260
93detection of light stimulus involved in visual perception (GO:0050908)2.46101260
94amino sugar metabolic process (GO:0006040)2.45525189
95water-soluble vitamin biosynthetic process (GO:0042364)2.45351060
96rRNA modification (GO:0000154)2.45074782
97pH reduction (GO:0045851)2.44687963
98succinate metabolic process (GO:0006105)2.41865373
99adaptation of signaling pathway (GO:0023058)2.40899977
100triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40746225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.29768793
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.68450834
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02978670
4ZNF274_21170338_ChIP-Seq_K562_Hela3.01542312
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.81805726
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73413643
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33578541
8EWS_26573619_Chip-Seq_HEK293_Human2.30818902
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29630743
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.27004398
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.24509921
12VDR_22108803_ChIP-Seq_LS180_Human2.09117028
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.08079029
14PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98062648
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94794240
16PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77105001
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73619871
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69289722
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67415931
20VDR_23849224_ChIP-Seq_CD4+_Human1.66049043
21GATA3_21878914_ChIP-Seq_MCF-7_Human1.62366708
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59091791
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58391152
24TP53_22573176_ChIP-Seq_HFKS_Human1.53101906
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52192514
26AR_20517297_ChIP-Seq_VCAP_Human1.47963430
27MYC_18940864_ChIP-ChIP_HL60_Human1.44104052
28AUTS2_25519132_ChIP-Seq_293T-REX_Human1.44048362
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43627126
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41804112
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.40080041
32ELK1_19687146_ChIP-ChIP_HELA_Human1.39618779
33GATA3_26560356_Chip-Seq_TH2_Human1.39214732
34SOX2_19829295_ChIP-Seq_ESCs_Human1.38149273
35NANOG_19829295_ChIP-Seq_ESCs_Human1.38149273
36ER_23166858_ChIP-Seq_MCF-7_Human1.37126492
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36457145
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34657745
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.34657745
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34345821
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34032227
42NANOG_20526341_ChIP-Seq_ESCs_Human1.33919775
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.32607949
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32486040
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.31619184
46P300_19829295_ChIP-Seq_ESCs_Human1.29844467
47NCOR_22424771_ChIP-Seq_293T_Human1.29228184
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27486198
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26032702
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.23674259
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23503153
52HOXB7_26014856_ChIP-Seq_BT474_Human1.22215188
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21797845
54SMAD4_21741376_ChIP-Seq_EPCs_Human1.20945688
55TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20873358
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20050132
57GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.19910533
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.18549322
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16063268
60FOXP3_21729870_ChIP-Seq_TREG_Human1.15189730
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15110421
62TAF2_19829295_ChIP-Seq_ESCs_Human1.14884559
63CDX2_22108803_ChIP-Seq_LS180_Human1.14863904
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14854246
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13234837
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10504620
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10239133
68TCF4_22108803_ChIP-Seq_LS180_Human1.09506091
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07924767
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07541521
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06988352
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.06871450
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06341579
74NFYB_21822215_ChIP-Seq_K562_Human1.03996080
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02464118
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02439192
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02104999
78GATA3_26560356_Chip-Seq_TH1_Human1.01798141
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00867428
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00206953
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98678319
82RBPJ_21746931_ChIP-Seq_IB4_Human0.98263859
83GATA6_21074721_ChIP-Seq_CACO-2_Human0.96433824
84MYC_19829295_ChIP-Seq_ESCs_Human0.96394543
85NOTCH1_21737748_ChIP-Seq_TLL_Human0.96090230
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95388215
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94930535
88STAT3_18555785_Chip-Seq_ESCs_Mouse0.93858828
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93605297
90PHF8_20622853_ChIP-Seq_HELA_Human0.93125006
91CTCF_18555785_Chip-Seq_ESCs_Mouse0.92662738
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.92648855
93IRF8_21731497_ChIP-ChIP_J774_Mouse0.92539690
94HNFA_21074721_ChIP-Seq_CACO-2_Human0.91296240
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.90765729
96RUNX_20019798_ChIP-Seq_JUKART_Human0.90059063
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90029988
98STAT3_23295773_ChIP-Seq_U87_Human0.89653727
99NFYA_21822215_ChIP-Seq_K562_Human0.88979984
100P53_22387025_ChIP-Seq_ESCs_Mouse0.88950758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok4.14829030
2MP0005646_abnormal_pituitary_gland3.23198184
3MP0004885_abnormal_endolymph2.96166644
4MP0003646_muscle_fatigue2.77528415
5MP0005671_abnormal_response_to2.68488044
6MP0005645_abnormal_hypothalamus_physiol2.61185657
7MP0002736_abnormal_nociception_after2.21611127
8MP0005387_immune_system_phenotype2.05120988
9MP0001790_abnormal_immune_system2.05120988
10MP0003806_abnormal_nucleotide_metabolis2.02906942
11MP0004142_abnormal_muscle_tone2.02220814
12MP0005084_abnormal_gallbladder_morpholo1.93968219
13MP0005365_abnormal_bile_salt1.85283634
14MP0003300_gastrointestinal_ulcer1.84434372
15MP0009785_altered_susceptibility_to1.81761813
16MP0002148_abnormal_hypersensitivity_rea1.81610030
17MP0008872_abnormal_physiological_respon1.81397090
18MP0002006_tumorigenesis1.80935202
19MP0005464_abnormal_platelet_physiology1.79746911
20MP0001968_abnormal_touch/_nociception1.79147196
21MP0002163_abnormal_gland_morphology1.78103077
22MP0005058_abnormal_lysosome_morphology1.72691058
23MP0002638_abnormal_pupillary_reflex1.64424295
24MP0003786_premature_aging1.63900094
25MP0002837_dystrophic_cardiac_calcinosis1.61473124
26MP0003045_fibrosis1.60949118
27MP0008877_abnormal_DNA_methylation1.58852540
28MP0000685_abnormal_immune_system1.58190576
29MP0000013_abnormal_adipose_tissue1.56654554
30MP0003693_abnormal_embryo_hatching1.54169325
31MP0002139_abnormal_hepatobiliary_system1.53971727
32MP0006054_spinal_hemorrhage1.50121911
33MP0001984_abnormal_olfaction1.49279149
34MP0001835_abnormal_antigen_presentation1.49043577
35MP0002876_abnormal_thyroid_physiology1.48981597
36MP0005551_abnormal_eye_electrophysiolog1.47977039
37MP0001800_abnormal_humoral_immune1.45157697
38MP0002723_abnormal_immune_serum1.44445327
39MP0000383_abnormal_hair_follicle1.44214236
40MP0002938_white_spotting1.42226772
41MP0003638_abnormal_response/metabolism_1.39340661
42MP0004147_increased_porphyrin_level1.38550042
43MP0002138_abnormal_hepatobiliary_system1.37471950
44MP0010155_abnormal_intestine_physiology1.36905814
45MP0003787_abnormal_imprinting1.36018228
46MP0001986_abnormal_taste_sensitivity1.35030998
47MP0001764_abnormal_homeostasis1.34306524
48MP0009764_decreased_sensitivity_to1.33994991
49MP0003195_calcinosis1.32816266
50MP0002452_abnormal_antigen_presenting1.31072225
51MP0003186_abnormal_redox_activity1.30405795
52MP0005647_abnormal_sex_gland1.27539732
53MP0003121_genomic_imprinting1.26921350
54MP0002735_abnormal_chemical_nociception1.25143786
55MP0002420_abnormal_adaptive_immunity1.24880313
56MP0008007_abnormal_cellular_replicative1.23583243
57MP0001819_abnormal_immune_cell1.22447977
58MP0006082_CNS_inflammation1.21107982
59MP0005000_abnormal_immune_tolerance1.21073169
60MP0005025_abnormal_response_to1.20976989
61MP0002102_abnormal_ear_morphology1.20900722
62MP0010329_abnormal_lipoprotein_level1.20634950
63MP0005310_abnormal_salivary_gland1.17698874
64MP0006035_abnormal_mitochondrial_morpho1.17539917
65MP0001845_abnormal_inflammatory_respons1.15732169
66MP0005408_hypopigmentation1.13529551
67MP0005410_abnormal_fertilization1.12529988
68MP0008469_abnormal_protein_level1.12078268
69MP0002166_altered_tumor_susceptibility1.11734563
70MP0002733_abnormal_thermal_nociception1.10746732
71MP0003718_maternal_effect1.10022907
72MP0006276_abnormal_autonomic_nervous1.08106153
73MP0002419_abnormal_innate_immunity1.07855302
74MP0008004_abnormal_stomach_pH1.04596016
75MP0005379_endocrine/exocrine_gland_phen1.02438356
76MP0003890_abnormal_embryonic-extraembry1.01615972
77MP0000427_abnormal_hair_cycle0.99391493
78MP0004381_abnormal_hair_follicle0.99301453
79MP0005075_abnormal_melanosome_morpholog0.98755422
80MP0001970_abnormal_pain_threshold0.95013329
81MP0009765_abnormal_xenobiotic_induced0.91505823
82MP0009840_abnormal_foam_cell0.91438745
83MP0003303_peritoneal_inflammation0.90615972
84MP0005253_abnormal_eye_physiology0.90434868
85MP0009333_abnormal_splenocyte_physiolog0.86746726
86MP0006036_abnormal_mitochondrial_physio0.86127667
87MP0002277_abnormal_respiratory_mucosa0.84679490
88MP0000647_abnormal_sebaceous_gland0.83252906
89MP0005319_abnormal_enzyme/_coenzyme0.81282176
90MP0008058_abnormal_DNA_repair0.80981361
91MP0001919_abnormal_reproductive_system0.80700235
92MP0006292_abnormal_olfactory_placode0.80362968
93MP0005083_abnormal_biliary_tract0.80134149
94MP0004019_abnormal_vitamin_homeostasis0.79454750
95MP0001501_abnormal_sleep_pattern0.79251298
96MP0009046_muscle_twitch0.79047129
97MP0000470_abnormal_stomach_morphology0.78812236
98MP0008873_increased_physiological_sensi0.78732822
99MP0003724_increased_susceptibility_to0.75870166
100MP0005332_abnormal_amino_acid0.75622693

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the renal cortex (HP:0011035)4.60952968
2Hypoproteinemia (HP:0003075)4.54744843
3Reduced antithrombin III activity (HP:0001976)4.07868228
4Type I transferrin isoform profile (HP:0003642)3.97574266
5Tubulointerstitial fibrosis (HP:0005576)3.58698259
6Congenital stationary night blindness (HP:0007642)3.48592253
7Renal cortical cysts (HP:0000803)3.43449854
8Dyschromatopsia (HP:0007641)3.39670561
9Abnormality of DNA repair (HP:0003254)3.24462002
10Stomatitis (HP:0010280)3.18751767
11Abnormal glycosylation (HP:0012345)3.03807954
12Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.03807954
13Abnormal protein N-linked glycosylation (HP:0012347)3.03807954
14Abnormal protein glycosylation (HP:0012346)3.03807954
15Abnormality of the renal medulla (HP:0100957)3.02248617
16Oligomenorrhea (HP:0000876)2.98793810
17Progressive inability to walk (HP:0002505)2.95245263
18Pancreatic cysts (HP:0001737)2.93707150
19Abnormality of the labia minora (HP:0012880)2.90211029
20Tubulointerstitial abnormality (HP:0001969)2.81627991
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81289261
22Abnormality of alanine metabolism (HP:0010916)2.81289261
23Hyperalaninemia (HP:0003348)2.81289261
24Decreased subcutaneous fat (HP:0001002)2.73839643
25Hypoplasia of the pons (HP:0012110)2.70334387
26Poor head control (HP:0002421)2.67279404
27Methylmalonic acidemia (HP:0002912)2.64766331
28Tubular atrophy (HP:0000092)2.60938386
29Clumsiness (HP:0002312)2.53989236
30Central scotoma (HP:0000603)2.53310997
31Attenuation of retinal blood vessels (HP:0007843)2.53263045
32Abnormality of the pons (HP:0007361)2.51069388
33Constricted visual fields (HP:0001133)2.50761512
34Optic disc pallor (HP:0000543)2.49905332
35Supernumerary spleens (HP:0009799)2.46217345
36Polyuria (HP:0000103)2.45921724
37Pancreatic fibrosis (HP:0100732)2.45589306
38Optic neuritis (HP:0100653)2.45360873
39Retrobulbar optic neuritis (HP:0100654)2.45360873
40Nephronophthisis (HP:0000090)2.43224693
41Acute necrotizing encephalopathy (HP:0006965)2.38871566
42Inability to walk (HP:0002540)2.37623847
43Fair hair (HP:0002286)2.34715604
44Hypochromic microcytic anemia (HP:0004840)2.34536927
45Metabolic alkalosis (HP:0200114)2.33461648
46Hepatocellular necrosis (HP:0001404)2.31011356
47CNS demyelination (HP:0007305)2.27273763
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.26396682
49Hypokalemic alkalosis (HP:0001949)2.25348231
50Increased CSF lactate (HP:0002490)2.24667960
51Increased IgM level (HP:0003496)2.23818870
52Macular degeneration (HP:0000608)2.23210591
53Keratoconus (HP:0000563)2.23150602
54Increased corneal curvature (HP:0100692)2.23150602
55Esophageal atresia (HP:0002032)2.20691977
56Acute encephalopathy (HP:0006846)2.17616487
57Amaurosis fugax (HP:0100576)2.13200067
58Abnormal mitochondria in muscle tissue (HP:0008316)2.12228144
59Abolished electroretinogram (ERG) (HP:0000550)2.12178915
60Hepatic necrosis (HP:0002605)2.09720378
61Hypoplasia of the uterus (HP:0000013)2.09470609
62Vacuolated lymphocytes (HP:0001922)2.08322461
63Generalized hypopigmentation of hair (HP:0011358)2.07633849
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05137003
65Abnormal drinking behavior (HP:0030082)2.04922095
66Polydipsia (HP:0001959)2.04922095
67IgG deficiency (HP:0004315)2.02638851
68Facial diplegia (HP:0001349)2.02604398
69Progressive macrocephaly (HP:0004481)2.00057227
70Keratitis (HP:0000491)2.00012648
71Mitochondrial inheritance (HP:0001427)1.98188663
72Decreased central vision (HP:0007663)1.98104083
73Spontaneous abortion (HP:0005268)1.97660908
74Abnormality of the ileum (HP:0001549)1.96150580
75Abnormal urine output (HP:0012590)1.95593987
76Absent speech (HP:0001344)1.94875874
77Abnormality of T cell number (HP:0011839)1.94827531
78Orchitis (HP:0100796)1.93677560
79Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93313709
80Abnormality of the heme biosynthetic pathway (HP:0010472)1.93180903
81Abnormal biliary tract morphology (HP:0012440)1.92509042
82Methylmalonic aciduria (HP:0012120)1.91717881
83Abnormality of transition element cation homeostasis (HP:0011030)1.90356050
84Clubbing of toes (HP:0100760)1.88632096
85Molar tooth sign on MRI (HP:0002419)1.88454480
86Abnormality of midbrain morphology (HP:0002418)1.88454480
87Meckel diverticulum (HP:0002245)1.88067782
88Abnormal rod and cone electroretinograms (HP:0008323)1.84323532
89Tongue fasciculations (HP:0001308)1.83687954
90Cystic liver disease (HP:0006706)1.82363485
91Hypophosphatemic rickets (HP:0004912)1.81058597
92Keratoconjunctivitis (HP:0001096)1.79878006
93Metaphyseal irregularity (HP:0003025)1.78491995
94Exotropia (HP:0000577)1.78211121
953-Methylglutaconic aciduria (HP:0003535)1.77631924
96Arterial thrombosis (HP:0004420)1.75404438
97Arthropathy (HP:0003040)1.75177290
98Increased neuronal autofluorescent lipopigment (HP:0002074)1.74652340
99Abnormality of methionine metabolism (HP:0010901)1.74100699
100T lymphocytopenia (HP:0005403)1.73516097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK93.66008788
2MAP4K23.54869159
3MAP3K122.79646319
4IKBKB2.75509976
5NUAK12.57494933
6ADRBK22.52937635
7EIF2AK32.37546857
8VRK22.36966579
9GRK12.30802660
10MAP3K132.30623864
11MYLK2.24841104
12TAOK32.24753518
13TLK12.24514018
14FRK2.20654714
15MST42.10055671
16TRIM282.01584901
17MAP4K11.64742651
18VRK11.64425708
19ZAK1.63715472
20TXK1.57966644
21DAPK11.47058227
22PINK11.39147101
23IKBKE1.34902539
24MAP3K141.33853897
25TGFBR11.32013639
26SYK1.30871661
27PHKG11.25896872
28PHKG21.25896872
29GRK51.23023555
30GRK71.12216944
31BLK1.10724171
32JAK31.08926500
33BMPR1B1.08725738
34TIE11.08363133
35CAMKK21.07700973
36PLK21.06935874
37OXSR11.04830632
38DAPK31.04560741
39DAPK21.04309504
40CHUK1.00238906
41WNK30.98345225
42PTK2B0.97630338
43PRKCG0.95254167
44BCR0.91367324
45PIK3CA0.88859543
46CSF1R0.88377977
47PRKCE0.87837439
48BCKDK0.85297187
49CSNK1G10.82785145
50CSNK1G30.82508487
51ADRBK10.81973370
52MAPKAPK50.80736219
53BUB10.80364586
54CAMK2D0.79707061
55ACVR1B0.77290733
56TEC0.75998642
57BTK0.75707065
58MATK0.72174592
59EIF2AK10.72125630
60PASK0.71615975
61LYN0.70707852
62PRKAA20.70486707
63FLT30.70201958
64PLK30.69920745
65EIF2AK20.69475154
66ITK0.67583865
67DYRK20.66074176
68NLK0.65061121
69PIK3CG0.62615052
70CSNK1G20.59386028
71MAP2K60.58816118
72INSRR0.58534656
73TNK20.57812440
74PRKCQ0.57503670
75ERBB40.57356145
76PRKCD0.54122311
77CCNB10.53543019
78PDK20.53439040
79CSNK1A10.52866304
80FGR0.51580912
81DYRK1B0.47876610
82KIT0.45378614
83PRKACA0.44672853
84TAF10.44628311
85PRKCA0.44499508
86ILK0.44287881
87PRKG10.43558414
88MAPK100.43048692
89TGFBR20.42479259
90CSNK1A1L0.42373305
91CAMK2B0.38897097
92CAMK2A0.38531097
93PAK20.35978027
94LCK0.34877322
95NME10.34730628
96PRKCI0.33566764
97CAMK2G0.32364933
98ABL20.32250708
99GSK3A0.32165997
100ZAP700.31202100

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046722.92027948
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46009998
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28690040
4Antigen processing and presentation_Homo sapiens_hsa046122.25139330
5Oxidative phosphorylation_Homo sapiens_hsa001902.16134586
6Nitrogen metabolism_Homo sapiens_hsa009102.13499606
7Proteasome_Homo sapiens_hsa030502.12656169
8Protein export_Homo sapiens_hsa030602.11842613
9Allograft rejection_Homo sapiens_hsa053302.01485363
10Phototransduction_Homo sapiens_hsa047441.94911244
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94593677
12Fanconi anemia pathway_Homo sapiens_hsa034601.87834704
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.84310609
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83514119
15Primary immunodeficiency_Homo sapiens_hsa053401.79096328
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76825726
17Graft-versus-host disease_Homo sapiens_hsa053321.67888035
18Type I diabetes mellitus_Homo sapiens_hsa049401.63389895
19Linoleic acid metabolism_Homo sapiens_hsa005911.62530309
20Nucleotide excision repair_Homo sapiens_hsa034201.61223460
21Asthma_Homo sapiens_hsa053101.60807504
22Caffeine metabolism_Homo sapiens_hsa002321.58225905
23Tryptophan metabolism_Homo sapiens_hsa003801.56410016
24Homologous recombination_Homo sapiens_hsa034401.53676635
25Propanoate metabolism_Homo sapiens_hsa006401.51431224
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47911929
27Rheumatoid arthritis_Homo sapiens_hsa053231.46002364
28One carbon pool by folate_Homo sapiens_hsa006701.41423969
29Autoimmune thyroid disease_Homo sapiens_hsa053201.40885504
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40374381
31Arachidonic acid metabolism_Homo sapiens_hsa005901.38276273
32Chemical carcinogenesis_Homo sapiens_hsa052041.38261907
33Parkinsons disease_Homo sapiens_hsa050121.37869817
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36092706
35Glycerolipid metabolism_Homo sapiens_hsa005611.33033531
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31010602
37beta-Alanine metabolism_Homo sapiens_hsa004101.29064250
38Histidine metabolism_Homo sapiens_hsa003401.28382058
39N-Glycan biosynthesis_Homo sapiens_hsa005101.28041705
40Ether lipid metabolism_Homo sapiens_hsa005651.27657839
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27266795
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17234854
43Hematopoietic cell lineage_Homo sapiens_hsa046401.16623785
44Basal transcription factors_Homo sapiens_hsa030221.13747067
45Butanoate metabolism_Homo sapiens_hsa006501.13179641
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11685364
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11383877
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10231746
49RNA degradation_Homo sapiens_hsa030181.09256977
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07843431
51Collecting duct acid secretion_Homo sapiens_hsa049661.02267417
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02144619
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.97319994
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95455784
55Selenocompound metabolism_Homo sapiens_hsa004500.93804801
56Glutathione metabolism_Homo sapiens_hsa004800.93017179
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90769539
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89796961
59Base excision repair_Homo sapiens_hsa034100.89157141
60RNA polymerase_Homo sapiens_hsa030200.87720358
61Steroid biosynthesis_Homo sapiens_hsa001000.87717587
62Lysosome_Homo sapiens_hsa041420.87287205
63Pyruvate metabolism_Homo sapiens_hsa006200.87272207
64Staphylococcus aureus infection_Homo sapiens_hsa051500.84310816
65Olfactory transduction_Homo sapiens_hsa047400.84124210
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80779128
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79530563
68Peroxisome_Homo sapiens_hsa041460.79466073
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.78369050
70Retinol metabolism_Homo sapiens_hsa008300.71571291
71Sulfur metabolism_Homo sapiens_hsa009200.70163387
72T cell receptor signaling pathway_Homo sapiens_hsa046600.67418800
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.66682338
74Legionellosis_Homo sapiens_hsa051340.66359595
75Systemic lupus erythematosus_Homo sapiens_hsa053220.65162712
76Huntingtons disease_Homo sapiens_hsa050160.63595274
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62528134
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61547137
79Ovarian steroidogenesis_Homo sapiens_hsa049130.59923296
80Non-homologous end-joining_Homo sapiens_hsa034500.58909556
81Renin-angiotensin system_Homo sapiens_hsa046140.58123449
82Mineral absorption_Homo sapiens_hsa049780.58023425
83Metabolic pathways_Homo sapiens_hsa011000.57534434
84Circadian rhythm_Homo sapiens_hsa047100.57527252
85Purine metabolism_Homo sapiens_hsa002300.57345122
86Alzheimers disease_Homo sapiens_hsa050100.57160779
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56961582
88Vitamin digestion and absorption_Homo sapiens_hsa049770.55202981
89Taste transduction_Homo sapiens_hsa047420.52596090
90African trypanosomiasis_Homo sapiens_hsa051430.51699883
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.51536100
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.50640078
93RNA transport_Homo sapiens_hsa030130.45607118
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44813469
95ABC transporters_Homo sapiens_hsa020100.42602527
96Leishmaniasis_Homo sapiens_hsa051400.39516320
97Tyrosine metabolism_Homo sapiens_hsa003500.39234438
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.36061565
99Salivary secretion_Homo sapiens_hsa049700.34591828
100Serotonergic synapse_Homo sapiens_hsa047260.32951517

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