ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.86272200
2	L-fucose catabolic process (GO:0042355)	4.95875053
3	fucose catabolic process (GO:0019317)	4.95875053
4	L-fucose metabolic process (GO:0042354)	4.95875053
5	cellular ketone body metabolic process (GO:0046950)	3.85145276
6	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.82051338
7	protein polyglutamylation (GO:0018095)	3.79097646
8	DNA deamination (GO:0045006)	3.78743550
9	tryptophan catabolic process (GO:0006569)	3.76784791
10	indole-containing compound catabolic process (GO:0042436)	3.76784791
11	indolalkylamine catabolic process (GO:0046218)	3.76784791
12	platelet dense granule organization (GO:0060155)	3.58704864
13	negative regulation of telomere maintenance (GO:0032205)	3.57986411
14	kynurenine metabolic process (GO:0070189)	3.57421517
15	axoneme assembly (GO:0035082)	3.45356914
16	response to pheromone (GO:0019236)	3.43024238
17	ketone body metabolic process (GO:1902224)	3.40971511
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.38326093
19	detection of light stimulus involved in visual perception (GO:0050908)	3.38326093
20	nephron tubule morphogenesis (GO:0072078)	3.30852677
21	nephron epithelium morphogenesis (GO:0072088)	3.30852677
22	protein complex biogenesis (GO:0070271)	3.27451550
23	indolalkylamine metabolic process (GO:0006586)	3.22790079
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.22089626
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.21017422
26	NADH dehydrogenase complex assembly (GO:0010257)	3.21017422
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.21017422
28	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.16172230
29	cornea development in camera-type eye (GO:0061303)	3.09831943
30	tryptophan metabolic process (GO:0006568)	3.04396655
31	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.03028439
32	regulation of translation, ncRNA-mediated (GO:0045974)	3.03028439
33	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.03028439
34	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.00200312
35	regulation of hexokinase activity (GO:1903299)	2.99905665
36	regulation of glucokinase activity (GO:0033131)	2.99905665
37	regulation of microtubule-based movement (GO:0060632)	2.99725954
38	kidney morphogenesis (GO:0060993)	2.96757384
39	regulation of cilium movement (GO:0003352)	2.94635414
40	epithelial cilium movement (GO:0003351)	2.92648118
41	rRNA catabolic process (GO:0016075)	2.88524811
42	sulfation (GO:0051923)	2.88252077
43	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.87902680
44	water-soluble vitamin biosynthetic process (GO:0042364)	2.84272917
45	piRNA metabolic process (GO:0034587)	2.83913198
46	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.78792565
47	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.76787515
48	hindbrain development (GO:0030902)	2.75290504
49	respiratory chain complex IV assembly (GO:0008535)	2.73628987
50	amine catabolic process (GO:0009310)	2.73353028
51	cellular biogenic amine catabolic process (GO:0042402)	2.73353028
52	cilium morphogenesis (GO:0060271)	2.73350073
53	synaptic transmission, cholinergic (GO:0007271)	2.72906766
54	fucosylation (GO:0036065)	2.71326786
55	glycerophospholipid catabolic process (GO:0046475)	2.71132467
56	nonmotile primary cilium assembly (GO:0035058)	2.71007604
57	positive regulation of fatty acid transport (GO:2000193)	2.70762364
58	cellular response to ATP (GO:0071318)	2.70347467
59	protein-cofactor linkage (GO:0018065)	2.70278251
60	maturation of 5.8S rRNA (GO:0000460)	2.68631817
61	neuronal action potential (GO:0019228)	2.68443764
62	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.67381305
63	regulation of action potential (GO:0098900)	2.67002516
64	rhodopsin mediated signaling pathway (GO:0016056)	2.64603677
65	regulation of triglyceride biosynthetic process (GO:0010866)	2.64237266
66	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.63832055
67	preassembly of GPI anchor in ER membrane (GO:0016254)	2.63157787
68	atrial cardiac muscle cell action potential (GO:0086014)	2.62976893
69	cAMP catabolic process (GO:0006198)	2.61834461
70	indole-containing compound metabolic process (GO:0042430)	2.60986931
71	gamma-aminobutyric acid transport (GO:0015812)	2.59859338
72	reflex (GO:0060004)	2.59546636
73	somite development (GO:0061053)	2.58340887
74	primary amino compound metabolic process (GO:1901160)	2.57301442
75	protein import into peroxisome matrix (GO:0016558)	2.56694455
76	neural tube formation (GO:0001841)	2.54793619
77	mannosylation (GO:0097502)	2.53172132
78	pyrimidine nucleobase catabolic process (GO:0006208)	2.51541154
79	cilium or flagellum-dependent cell motility (GO:0001539)	2.50806896
80	positive regulation of prostaglandin secretion (GO:0032308)	2.50700325
81	renal tubule morphogenesis (GO:0061333)	2.49376887
82	retinal cone cell development (GO:0046549)	2.47153215
83	cytochrome complex assembly (GO:0017004)	2.46131965
84	cilium organization (GO:0044782)	2.44763989
85	replication fork processing (GO:0031297)	2.44473364
86	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.44429622
87	ATP synthesis coupled proton transport (GO:0015986)	2.44429622
88	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.42208567
89	regulation of telomere maintenance (GO:0032204)	2.41831100
90	negative regulation of mast cell activation (GO:0033004)	2.41474460
91	adaptation of signaling pathway (GO:0023058)	2.40210438
92	protein K6-linked ubiquitination (GO:0085020)	2.39706045
93	postsynaptic membrane organization (GO:0001941)	2.39288735
94	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.38672434
95	multicellular organism reproduction (GO:0032504)	2.38255401
96	cilium movement (GO:0003341)	2.37648169
97	ubiquinone biosynthetic process (GO:0006744)	2.35336831
98	cilium assembly (GO:0042384)	2.33255466
99	exogenous drug catabolic process (GO:0042738)	2.33229073
100	endoderm formation (GO:0001706)	2.33064760

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.51796917
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.72557158
3	VDR_22108803_ChIP-Seq_LS180_Human	3.46903328
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.91606059
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.40044053
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.38099669
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.29082994
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.18936082
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15226442
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10934358
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.02337614
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97478104
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.92778997
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91409367
15	IGF1R_20145208_ChIP-Seq_DFB_Human	1.85624254
16	P300_19829295_ChIP-Seq_ESCs_Human	1.79039809
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76881469
18	EWS_26573619_Chip-Seq_HEK293_Human	1.76460374
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75486967
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.71997300
21	FUS_26573619_Chip-Seq_HEK293_Human	1.68682984
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66975001
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66111951
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.64894466
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.64760732
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.62858150
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.60966878
28	REST_21632747_ChIP-Seq_MESCs_Mouse	1.60487665
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.58487418
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.57556404
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56990223
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.56233074
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54017284
34	* TP53_22573176_ChIP-Seq_HFKS_Human	1.52456972
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.50879759
36	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.49748408
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46829526
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45341216
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45341216
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.41030990
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.41030990
42	AR_25329375_ChIP-Seq_VCAP_Human	1.40600961
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.39415919
44	STAT3_23295773_ChIP-Seq_U87_Human	1.39287668
45	AR_21572438_ChIP-Seq_LNCaP_Human	1.39220216
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37939279
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37939279
48	TCF4_23295773_ChIP-Seq_U87_Human	1.36158950
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35448347
50	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35294612
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.34230727
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33556621
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33220610
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30788949
55	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29239753
56	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26785651
57	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.26528641
58	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.25869503
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25255377
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24369887
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24256683
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.23872165
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23872165
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23388968
65	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22334315
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21328567
67	* HOXB7_26014856_ChIP-Seq_BT474_Human	1.21039349
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20937485
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.20301449
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.18482891
71	AR_20517297_ChIP-Seq_VCAP_Human	1.17127383
72	NCOR_22424771_ChIP-Seq_293T_Human	1.16989756
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15421523
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15302916
75	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.14650205
76	MYC_19829295_ChIP-Seq_ESCs_Human	1.14403586
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13134566
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11322688
79	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.10566298
80	TAF2_19829295_ChIP-Seq_ESCs_Human	1.10219540
81	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.09071202
82	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08982384
83	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08431820
84	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07553226
85	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.05788322
86	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.04825124
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04608341
88	ERA_21632823_ChIP-Seq_H3396_Human	1.04285398
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03587969
90	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.01897789
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01551747
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00392750
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00059265
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99743784
95	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.99651776
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99035113
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98244736
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97946334
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96980617
100	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.96792565

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.02927299
2	MP0004147_increased_porphyrin_level	2.80694260
3	MP0004885_abnormal_endolymph	2.78049127
4	MP0002102_abnormal_ear_morphology	2.72407127
5	MP0008877_abnormal_DNA_methylation	2.65723071
6	MP0005551_abnormal_eye_electrophysiolog	2.63378609
7	MP0008875_abnormal_xenobiotic_pharmacok	2.42680309
8	MP0006072_abnormal_retinal_apoptosis	2.41612263
9	MP0006292_abnormal_olfactory_placode	2.33710821
10	MP0001986_abnormal_taste_sensitivity	2.15186903
11	MP0004133_heterotaxia	2.08424058
12	MP0002876_abnormal_thyroid_physiology	2.05157415
13	MP0008872_abnormal_physiological_respon	2.03555265
14	MP0000569_abnormal_digit_pigmentation	1.98671309
15	MP0003011_delayed_dark_adaptation	1.95453600
16	MP0003880_abnormal_central_pattern	1.92413189
17	MP0004142_abnormal_muscle_tone	1.88171034
18	MP0009745_abnormal_behavioral_response	1.84937295
19	MP0004043_abnormal_pH_regulation	1.84568922
20	MP0009046_muscle_twitch	1.81956087
21	MP0002638_abnormal_pupillary_reflex	1.79505216
22	MP0002837_dystrophic_cardiac_calcinosis	1.79001019
23	MP0005253_abnormal_eye_physiology	1.75639558
24	MP0000427_abnormal_hair_cycle	1.74631606
25	MP0001968_abnormal_touch/_nociception	1.72529919
26	MP0002163_abnormal_gland_morphology	1.67872529
27	MP0003136_yellow_coat_color	1.66867254
28	MP0005645_abnormal_hypothalamus_physiol	1.66453435
29	MP0001501_abnormal_sleep_pattern	1.64455827
30	MP0005084_abnormal_gallbladder_morpholo	1.62891953
31	MP0006276_abnormal_autonomic_nervous	1.62742851
32	MP0001485_abnormal_pinna_reflex	1.61984418
33	MP0004742_abnormal_vestibular_system	1.59509375
34	MP0002272_abnormal_nervous_system	1.57876056
35	MP0002735_abnormal_chemical_nociception	1.57242868
36	MP0002653_abnormal_ependyma_morphology	1.49393120
37	MP0002938_white_spotting	1.48110115
38	MP0005379_endocrine/exocrine_gland_phen	1.41519344
39	MP0002557_abnormal_social/conspecific_i	1.38097912
40	MP0003646_muscle_fatigue	1.37166229
41	MP0002572_abnormal_emotion/affect_behav	1.37007247
42	MP0000631_abnormal_neuroendocrine_gland	1.36427600
43	MP0001984_abnormal_olfaction	1.36065110
44	MP0002733_abnormal_thermal_nociception	1.34354361
45	MP0002736_abnormal_nociception_after	1.33952892
46	MP0002254_reproductive_system_inflammat	1.33026601
47	MP0001486_abnormal_startle_reflex	1.30461163
48	MP0002064_seizures	1.30117879
49	MP0001529_abnormal_vocalization	1.28631144
50	MP0005646_abnormal_pituitary_gland	1.27218664
51	MP0003890_abnormal_embryonic-extraembry	1.26247464
52	MP0001970_abnormal_pain_threshold	1.25560086
53	MP0005386_behavior/neurological_phenoty	1.25142176
54	MP0004924_abnormal_behavior	1.25142176
55	MP0005167_abnormal_blood-brain_barrier	1.22453442
56	MP0003787_abnormal_imprinting	1.22244510
57	MP0000372_irregular_coat_pigmentation	1.19786158
58	MP0001905_abnormal_dopamine_level	1.18585974
59	MP0005195_abnormal_posterior_eye	1.15476996
60	MP0005389_reproductive_system_phenotype	1.13729907
61	MP0002234_abnormal_pharynx_morphology	1.11407701
62	MP0001919_abnormal_reproductive_system	1.10685268
63	MP0003718_maternal_effect	1.09861014
64	MP0003878_abnormal_ear_physiology	1.08620770
65	MP0005377_hearing/vestibular/ear_phenot	1.08620770
66	MP0002063_abnormal_learning/memory/cond	1.07939211
67	MP0002277_abnormal_respiratory_mucosa	1.04716302
68	MP0000383_abnormal_hair_follicle	1.03593570
69	MP0008775_abnormal_heart_ventricle	1.02740862
70	MP0003283_abnormal_digestive_organ	1.02156533
71	MP0002928_abnormal_bile_duct	1.01298513
72	MP0002160_abnormal_reproductive_system	1.00876172
73	MP0003635_abnormal_synaptic_transmissio	1.00613258
74	MP0003122_maternal_imprinting	0.99710494
75	MP0008995_early_reproductive_senescence	0.99370602
76	MP0000778_abnormal_nervous_system	0.97943460
77	MP0002067_abnormal_sensory_capabilities	0.97834169
78	MP0004145_abnormal_muscle_electrophysio	0.97206902
79	MP0002734_abnormal_mechanical_nocicepti	0.93493477
80	MP0000230_abnormal_systemic_arterial	0.91025317
81	MP0010386_abnormal_urinary_bladder	0.90621489
82	MP0000026_abnormal_inner_ear	0.90456289
83	MP0001324_abnormal_eye_pigmentation	0.88630297
84	MP0004215_abnormal_myocardial_fiber	0.87769249
85	MP0001963_abnormal_hearing_physiology	0.87072461
86	MP0002752_abnormal_somatic_nervous	0.84927176
87	MP0005423_abnormal_somatic_nervous	0.84492717
88	MP0000647_abnormal_sebaceous_gland	0.83472311
89	MP0001873_stomach_inflammation	0.82523927
90	MP0004019_abnormal_vitamin_homeostasis	0.82280664
91	MP0000566_synostosis	0.80745025
92	MP0001440_abnormal_grooming_behavior	0.80742143
93	MP0003137_abnormal_impulse_conducting	0.79907731
94	MP0002693_abnormal_pancreas_physiology	0.79106502
95	MP0005174_abnormal_tail_pigmentation	0.78336354
96	MP0001502_abnormal_circadian_rhythm	0.78194756
97	MP0009379_abnormal_foot_pigmentation	0.78147745
98	MP0005332_abnormal_amino_acid	0.76592343
99	MP0000049_abnormal_middle_ear	0.74846245
100	MP0002229_neurodegeneration	0.73824264

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.49956926
2	Molar tooth sign on MRI (HP:0002419)	4.49956926
3	Pancreatic cysts (HP:0001737)	4.21712555
4	Congenital stationary night blindness (HP:0007642)	3.94547199
5	Pancreatic fibrosis (HP:0100732)	3.80768459
6	Abnormality of the renal cortex (HP:0011035)	3.74697011
7	Nephronophthisis (HP:0000090)	3.69227447
8	True hermaphroditism (HP:0010459)	3.53585460
9	Type II lissencephaly (HP:0007260)	3.48469127
10	Abnormality of the renal medulla (HP:0100957)	3.34870059
11	Attenuation of retinal blood vessels (HP:0007843)	3.31922875
12	Inability to walk (HP:0002540)	3.07188635
13	Pendular nystagmus (HP:0012043)	2.98713632
14	Birth length less than 3rd percentile (HP:0003561)	2.95391950
15	Hyperventilation (HP:0002883)	2.92365320
16	Abnormal drinking behavior (HP:0030082)	2.92286629
17	Polydipsia (HP:0001959)	2.92286629
18	Renal cortical cysts (HP:0000803)	2.89226584
19	Concave nail (HP:0001598)	2.88179723
20	Large for gestational age (HP:0001520)	2.70174691
21	Tubular atrophy (HP:0000092)	2.66088144
22	Cerebellar dysplasia (HP:0007033)	2.62518622
23	Keratoconus (HP:0000563)	2.59701548
24	Increased corneal curvature (HP:0100692)	2.59701548
25	Progressive inability to walk (HP:0002505)	2.58904283
26	Congenital, generalized hypertrichosis (HP:0004540)	2.57638312
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.55405334
28	Abnormality of alanine metabolism (HP:0010916)	2.55405334
29	Hyperalaninemia (HP:0003348)	2.55405334
30	Broad-based gait (HP:0002136)	2.51776590
31	Lissencephaly (HP:0001339)	2.51705511
32	Abolished electroretinogram (ERG) (HP:0000550)	2.51508950
33	Cystic liver disease (HP:0006706)	2.49800463
34	Polyuria (HP:0000103)	2.49727632
35	Patellar aplasia (HP:0006443)	2.48135104
36	Abnormality of the pons (HP:0007361)	2.45705030
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.43129908
38	Decreased circulating renin level (HP:0003351)	2.42021285
39	Chronic hepatic failure (HP:0100626)	2.41306102
40	Aplasia/Hypoplasia of the patella (HP:0006498)	2.34367673
41	Hypoplasia of the pons (HP:0012110)	2.28581584
42	Absent/shortened dynein arms (HP:0200106)	2.28255247
43	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.28255247
44	Medial flaring of the eyebrow (HP:0010747)	2.23652115
45	Optic disc pallor (HP:0000543)	2.23459878
46	Fair hair (HP:0002286)	2.19091823
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.18969598
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.18969598
49	Sclerocornea (HP:0000647)	2.16254091
50	Furrowed tongue (HP:0000221)	2.13581026
51	Protruding tongue (HP:0010808)	2.12915857
52	Acute necrotizing encephalopathy (HP:0006965)	2.10626223
53	Acute encephalopathy (HP:0006846)	2.09097903
54	Decreased central vision (HP:0007663)	2.08346951
55	Bile duct proliferation (HP:0001408)	2.06942133
56	Abnormal biliary tract physiology (HP:0012439)	2.06942133
57	Clumsiness (HP:0002312)	2.04371570
58	Mitochondrial inheritance (HP:0001427)	2.01558707
59	Abnormal urine output (HP:0012590)	2.01134627
60	Focal motor seizures (HP:0011153)	1.99101056
61	Abnormal number of erythroid precursors (HP:0012131)	1.96607628
62	Pachygyria (HP:0001302)	1.96451628
63	Absent speech (HP:0001344)	1.95414657
64	Hyperglycinuria (HP:0003108)	1.93351472
65	Severe muscular hypotonia (HP:0006829)	1.91884181
66	Chorioretinal atrophy (HP:0000533)	1.91756369
67	Progressive macrocephaly (HP:0004481)	1.88071581
68	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87707024
69	Hypothermia (HP:0002045)	1.87036672
70	Duplicated collecting system (HP:0000081)	1.86822949
71	3-Methylglutaconic aciduria (HP:0003535)	1.86562159
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.83439226
73	Increased CSF lactate (HP:0002490)	1.82952822
74	Abnormality of the renal collecting system (HP:0004742)	1.82621331
75	Anencephaly (HP:0002323)	1.81954760
76	Abnormal mitochondria in muscle tissue (HP:0008316)	1.81373532
77	Widely spaced teeth (HP:0000687)	1.80911640
78	Stomach cancer (HP:0012126)	1.80232498
79	Methylmalonic acidemia (HP:0002912)	1.79954009
80	Agitation (HP:0000713)	1.79789791
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.79277784
82	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.78986918
83	Abnormality of the labia minora (HP:0012880)	1.77902084
84	Congenital hepatic fibrosis (HP:0002612)	1.77522590
85	Tachypnea (HP:0002789)	1.75624119
86	Abnormality of renal excretion (HP:0011036)	1.75525207
87	Nephrogenic diabetes insipidus (HP:0009806)	1.75485894
88	Generalized hypopigmentation of hair (HP:0011358)	1.75284441
89	Optic nerve hypoplasia (HP:0000609)	1.69663560
90	Male pseudohermaphroditism (HP:0000037)	1.69457831
91	Gait imbalance (HP:0002141)	1.68633986
92	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.68182538
93	Hypoplasia of the fovea (HP:0007750)	1.68182538
94	Breast hypoplasia (HP:0003187)	1.65977378
95	Abnormality of renin-angiotensin system (HP:0000847)	1.64908685
96	Absent thumb (HP:0009777)	1.64805625
97	Abnormality of cells of the erythroid lineage (HP:0012130)	1.64502572
98	Hypomagnesemia (HP:0002917)	1.62853445
99	Partial agenesis of the corpus callosum (HP:0001338)	1.59454039
100	Congenital primary aphakia (HP:0007707)	1.59253214

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.17340150
2	ADRBK2	3.82956935
3	INSRR	3.62886616
4	ACVR1B	3.06947891
5	BMPR1B	2.96178284
6	WNK4	2.95008983
7	CASK	2.80752969
8	ZAK	2.66575978
9	TLK1	2.65172973
10	GRK1	2.57699845
11	WNK3	2.46488620
12	NUAK1	2.40381129
13	PINK1	2.12082648
14	DAPK2	1.96960701
15	MAPK13	1.95034656
16	MAP4K2	1.73318842
17	CAMKK2	1.71788136
18	OXSR1	1.61163115
19	MKNK2	1.51794764
20	TAOK3	1.48277735
21	TXK	1.46349843
22	ADRBK1	1.41461437
23	STK38L	1.36719401
24	TGFBR1	1.29145251
25	MAP3K4	1.27470995
26	STK39	1.25083868
27	PNCK	1.23685158
28	TNIK	1.18797261
29	DYRK2	1.06600064
30	NTRK3	1.04658942
31	PAK3	1.03969454
32	PTK2B	0.92977334
33	NME1	0.92008182
34	PHKG1	0.90944088
35	PHKG2	0.90944088
36	PRKCE	0.90490839
37	MARK1	0.90447823
38	CSNK1G2	0.89917160
39	TRIM28	0.88598168
40	TIE1	0.88247640
41	CAMKK1	0.84671759
42	VRK1	0.84160381
43	NTRK2	0.83968661
44	MUSK	0.82409986
45	FGFR2	0.80736345
46	IKBKB	0.80344910
47	PRKCG	0.79564375
48	CAMK1D	0.79218871
49	NEK2	0.78925651
50	BRSK2	0.78295298
51	MAP2K6	0.76235499
52	PLK2	0.69885621
53	PIK3CA	0.69848560
54	MKNK1	0.67253019
55	WNK1	0.66431507
56	MAP2K7	0.66097741
57	RPS6KA5	0.65080158
58	PRKCQ	0.64955875
59	CSNK1G1	0.64607350
60	STK11	0.63126536
61	MAPKAPK3	0.62884028
62	EPHB2	0.62779368
63	CSNK1G3	0.61164305
64	CAMK1	0.60018381
65	CAMK1G	0.59745718
66	MAPK15	0.58868336
67	PRKCI	0.55841882
68	BCKDK	0.55341198
69	MAP2K2	0.53977307
70	CAMK2A	0.52309950
71	FLT3	0.51570499
72	SIK2	0.51511447
73	NLK	0.51499084
74	VRK2	0.50559092
75	PLK4	0.48559223
76	PRKACA	0.47864115
77	CDK3	0.47286559
78	PKN1	0.42462960
79	CHUK	0.42086590
80	KIT	0.41183971
81	PASK	0.39824347
82	WEE1	0.39782783
83	CSNK1A1L	0.38612364
84	BCR	0.38491689
85	GRK7	0.38377889
86	PLK3	0.37818743
87	PRKG1	0.34693922
88	CSNK1A1	0.33201171
89	PRKD3	0.32155151
90	PRKCA	0.32146326
91	RPS6KA6	0.30629345
92	CSNK1D	0.30255375
93	MAPKAPK5	0.29642430
94	MST4	0.29418340
95	ERBB3	0.28145299
96	STK3	0.27227648
97	PRKCZ	0.27180971
98	CAMK4	0.26983874
99	PRKAA2	0.26923643
100	LIMK1	0.26559853

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.89468172
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.79462870
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.67885710
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.67175181
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.63075635
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.53745196
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.53452188
8	Butanoate metabolism_Homo sapiens_hsa00650	2.43873725
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.33478525
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.17419346
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.11857172
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.10835096
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.01876898
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.00957481
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.97734849
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.96237661
17	Protein export_Homo sapiens_hsa03060	1.94497340
18	Nicotine addiction_Homo sapiens_hsa05033	1.87291513
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.78209264
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.75319073
21	Parkinsons disease_Homo sapiens_hsa05012	1.73837800
22	Caffeine metabolism_Homo sapiens_hsa00232	1.58416488
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.46004779
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.43257685
25	RNA polymerase_Homo sapiens_hsa03020	1.35510542
26	Homologous recombination_Homo sapiens_hsa03440	1.34935020
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34203604
28	Taste transduction_Homo sapiens_hsa04742	1.32042279
29	Peroxisome_Homo sapiens_hsa04146	1.27252683
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.26969847
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26167558
32	Basal transcription factors_Homo sapiens_hsa03022	1.24588682
33	Propanoate metabolism_Homo sapiens_hsa00640	1.23867766
34	Morphine addiction_Homo sapiens_hsa05032	1.22179039
35	Insulin secretion_Homo sapiens_hsa04911	1.21341191
36	Alzheimers disease_Homo sapiens_hsa05010	1.16797547
37	ABC transporters_Homo sapiens_hsa02010	1.15885630
38	Retinol metabolism_Homo sapiens_hsa00830	1.15380159
39	Huntingtons disease_Homo sapiens_hsa05016	1.14120584
40	Olfactory transduction_Homo sapiens_hsa04740	1.13954379
41	One carbon pool by folate_Homo sapiens_hsa00670	1.12091005
42	RNA degradation_Homo sapiens_hsa03018	1.11074533
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03693832
44	beta-Alanine metabolism_Homo sapiens_hsa00410	1.03437357
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03403464
46	Ribosome_Homo sapiens_hsa03010	1.03230045
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.02310630
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.02020416
49	Histidine metabolism_Homo sapiens_hsa00340	0.96801529
50	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.96197954
51	Serotonergic synapse_Homo sapiens_hsa04726	0.95421286
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.94124890
53	Regulation of autophagy_Homo sapiens_hsa04140	0.93324943
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.89811698
55	Circadian entrainment_Homo sapiens_hsa04713	0.88546181
56	GABAergic synapse_Homo sapiens_hsa04727	0.87505737
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.86781148
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.85946870
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85272386
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.82953884
61	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.79447232
62	Sulfur metabolism_Homo sapiens_hsa00920	0.77521865
63	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.77390339
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.72618488
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.70881562
66	Mineral absorption_Homo sapiens_hsa04978	0.70565387
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67135973
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.64915527
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64437278
70	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.61201997
71	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.60099131
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59730868
73	Metabolic pathways_Homo sapiens_hsa01100	0.58948434
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58928009
75	Proteasome_Homo sapiens_hsa03050	0.57771354
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.55106789
77	Sulfur relay system_Homo sapiens_hsa04122	0.54351415
78	Cocaine addiction_Homo sapiens_hsa05030	0.53744226
79	Primary immunodeficiency_Homo sapiens_hsa05340	0.52858956
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.52112526
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.51669795
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51094920
83	Salivary secretion_Homo sapiens_hsa04970	0.50745930
84	Asthma_Homo sapiens_hsa05310	0.49747074
85	Amphetamine addiction_Homo sapiens_hsa05031	0.49176455
86	Purine metabolism_Homo sapiens_hsa00230	0.48496449
87	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.44215719
88	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.44182814
89	Dopaminergic synapse_Homo sapiens_hsa04728	0.39748059
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39259683
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.38906242
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38561732
93	Circadian rhythm_Homo sapiens_hsa04710	0.38175730
94	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37279726
95	Fatty acid degradation_Homo sapiens_hsa00071	0.37049557
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36235975
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35696400
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.35691772
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.29028960
100	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.26305676

FTLP10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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