ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	7.90833185
2	regulation of retinoic acid receptor signaling pathway (GO:0048385)	7.17193848
3	glycerophospholipid catabolic process (GO:0046475)	5.53175038
4	intestinal cholesterol absorption (GO:0030299)	4.40954897
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.07755214
6	pseudouridine synthesis (GO:0001522)	4.05606119
7	basic amino acid transport (GO:0015802)	4.04959633
8	proteasome assembly (GO:0043248)	3.98419230
9	protein autoprocessing (GO:0016540)	3.92678193
10	regulation of oxidative phosphorylation (GO:0002082)	3.91864988
11	intestinal epithelial cell development (GO:0060576)	3.87332703
12	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.79570549
13	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.79274753
14	exocrine pancreas development (GO:0031017)	3.72040511
15	nucleoside transmembrane transport (GO:1901642)	3.68144473
16	single strand break repair (GO:0000012)	3.60901771
17	phospholipid catabolic process (GO:0009395)	3.36063646
18	sphingomyelin metabolic process (GO:0006684)	3.36050683
19	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.28614670
20	ATP hydrolysis coupled proton transport (GO:0015991)	3.28614670
21	tyrosine phosphorylation of STAT protein (GO:0007260)	3.25726153
22	transepithelial transport (GO:0070633)	3.25411552
23	regulation of acrosome reaction (GO:0060046)	3.21951698
24	negative regulation of keratinocyte proliferation (GO:0010839)	3.21384601
25	transferrin transport (GO:0033572)	3.12462557
26	regulation of DNA methylation (GO:0044030)	3.09282485
27	piRNA metabolic process (GO:0034587)	3.07504241
28	alanine transport (GO:0032328)	3.06299713
29	protein K6-linked ubiquitination (GO:0085020)	3.05706539
30	male meiosis I (GO:0007141)	3.05064811
31	nucleoside transport (GO:0015858)	3.03015372
32	regulation of cellular amino acid metabolic process (GO:0006521)	2.98943919
33	nitric oxide biosynthetic process (GO:0006809)	2.96857033
34	cobalamin metabolic process (GO:0009235)	2.95754150
35	regulation of cellular respiration (GO:0043457)	2.95202744
36	ER overload response (GO:0006983)	2.94424982
37	trivalent inorganic cation transport (GO:0072512)	2.93855908
38	ferric iron transport (GO:0015682)	2.93855908
39	snRNA transcription (GO:0009301)	2.93090510
40	positive regulation of cellular amine metabolic process (GO:0033240)	2.92263772
41	L-alpha-amino acid transmembrane transport (GO:1902475)	2.90677192
42	N-acetylglucosamine metabolic process (GO:0006044)	2.89342253
43	L-phenylalanine metabolic process (GO:0006558)	2.84780337
44	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.84780337
45	male meiosis (GO:0007140)	2.83702935
46	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.83338063
47	glycine transport (GO:0015816)	2.83150212
48	cardiac right ventricle morphogenesis (GO:0003215)	2.78479044
49	chaperone-mediated protein transport (GO:0072321)	2.77882062
50	regulation of hippo signaling (GO:0035330)	2.76449302
51	viral mRNA export from host cell nucleus (GO:0046784)	2.76100017
52	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.74990808
53	kidney morphogenesis (GO:0060993)	2.71828248
54	acrosome assembly (GO:0001675)	2.69771700
55	transcytosis (GO:0045056)	2.68845803
56	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.67462881
57	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.67462881
58	negative regulation of digestive system process (GO:0060457)	2.66927955
59	nodal signaling pathway (GO:0038092)	2.64150624
60	response to xenobiotic stimulus (GO:0009410)	2.60374400
61	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.58266983
62	sterol transport (GO:0015918)	2.56873495
63	cholesterol transport (GO:0030301)	2.56873495
64	mannosylation (GO:0097502)	2.56605047
65	hydrogen ion transmembrane transport (GO:1902600)	2.55915595
66	positive regulation of histone H3-K4 methylation (GO:0051571)	2.55873956
67	glycosylceramide metabolic process (GO:0006677)	2.55611247
68	ubiquinone metabolic process (GO:0006743)	2.54136178
69	regulation of pH (GO:0006885)	2.53812236
70	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.53780545
71	high-density lipoprotein particle remodeling (GO:0034375)	2.52944481
72	N-acetylneuraminate metabolic process (GO:0006054)	2.49039012
73	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.45582083
74	protein deneddylation (GO:0000338)	2.45370824
75	cullin deneddylation (GO:0010388)	2.44775778
76	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	2.43927090
77	ubiquinone biosynthetic process (GO:0006744)	2.43600627
78	positive regulation of gluconeogenesis (GO:0045722)	2.43277186
79	glucosamine-containing compound metabolic process (GO:1901071)	2.42737564
80	excretion (GO:0007588)	2.41698473
81	kinetochore assembly (GO:0051382)	2.41377882
82	proton transport (GO:0015992)	2.39968046
83	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.37640103
84	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.36685907
85	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.34541181
86	DNA methylation involved in gamete generation (GO:0043046)	2.33788390
87	negative regulation of macroautophagy (GO:0016242)	2.33264357
88	hydrogen transport (GO:0006818)	2.32264913
89	triglyceride homeostasis (GO:0070328)	2.31480871
90	acylglycerol homeostasis (GO:0055090)	2.31480871
91	proline transport (GO:0015824)	2.31476114
92	lactate metabolic process (GO:0006089)	2.31004688
93	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.30718890
94	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.30412143
95	regulation of cellular amine metabolic process (GO:0033238)	2.30402202
96	rRNA modification (GO:0000154)	2.29890963
97	regulation of triglyceride biosynthetic process (GO:0010866)	2.29748536
98	L-phenylalanine catabolic process (GO:0006559)	2.29364190
99	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.29364190
100	regulation of keratinocyte proliferation (GO:0010837)	2.29195617

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.54762638
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.75457093
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.00059907
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.54933852
5	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.45419670
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.10323506
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.92970247
8	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.80287735
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.73149944
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.59530953
11	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.39837952
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33673939
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.31095419
14	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.25058992
15	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.17727372
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.17367518
17	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.01705697
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.90723410
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.90335382
20	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.82248895
21	GATA1_22025678_ChIP-Seq_K562_Human	1.79434980
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.77535191
23	GABP_19822575_ChIP-Seq_HepG2_Human	1.68792092
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62675026
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.61540634
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.60323699
27	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.59075644
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.56236547
29	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.54399909
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51391060
31	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.50829801
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47755725
33	HOXB7_26014856_ChIP-Seq_BT474_Human	1.44447220
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.42157561
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41392775
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40820111
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.38051061
38	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.33956501
39	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.33007945
40	AR_20517297_ChIP-Seq_VCAP_Human	1.30917707
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.30207912
42	GATA4_25053715_ChIP-Seq_YYC3_Human	1.30073301
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.29528464
44	ZNF263_19887448_ChIP-Seq_K562_Human	1.28607325
45	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.28163781
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.27709526
47	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.25575889
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22736726
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22736726
50	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.21199864
51	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.18855541
52	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.18496315
53	GATA6_25053715_ChIP-Seq_YYC3_Human	1.17979079
54	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.17879294
55	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.17879294
56	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.17879294
57	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.16247379
58	VDR_22108803_ChIP-Seq_LS180_Human	1.15644505
59	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.12830504
60	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.12123842
61	ELF5_23300383_ChIP-Seq_T47D_Human	1.11797247
62	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.10136219
63	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.10032371
64	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.09762942
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08891170
66	KDM5A_27292631_Chip-Seq_BREAST_Human	1.08575189
67	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.07240343
68	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.07002220
69	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.05661688
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.05428120
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05390096
72	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.02343483
73	CDX2_22108803_ChIP-Seq_LS180_Human	1.02173149
74	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.02081167
75	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.01786233
76	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.00279544
77	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.00082814
78	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.99051825
79	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.98810365
80	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.98569951
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.97586197
82	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.96841961
83	NCOR_22424771_ChIP-Seq_293T_Human	0.95926412
84	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.95217594
85	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.93840327
86	ERA_21632823_ChIP-Seq_H3396_Human	0.92842802
87	ERG_20517297_ChIP-Seq_VCAP_Human	0.90638086
88	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.90052857
89	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.89953508
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.89653812
91	MYC_19829295_ChIP-Seq_ESCs_Human	0.89190160
92	CEBPB_22108803_ChIP-Seq_LS180_Human	0.88727448
93	TTF2_22483619_ChIP-Seq_HELA_Human	0.87437455
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.86585290
95	SOX2_20726797_ChIP-Seq_SW620_Human	0.86412110
96	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.86359555
97	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.86033846
98	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.85752437
99	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.85544645
100	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85103814

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002254_reproductive_system_inflammat	6.81849501
2	MP0002139_abnormal_hepatobiliary_system	4.43093510
3	MP0002876_abnormal_thyroid_physiology	4.15612189
4	MP0002138_abnormal_hepatobiliary_system	3.39068514
5	MP0003878_abnormal_ear_physiology	2.99696800
6	MP0005377_hearing/vestibular/ear_phenot	2.99696800
7	MP0008995_early_reproductive_senescence	2.68157844
8	MP0003186_abnormal_redox_activity	2.59269297
9	MP0008872_abnormal_physiological_respon	2.58217761
10	MP0008877_abnormal_DNA_methylation	2.56178763
11	MP0002163_abnormal_gland_morphology	2.54907285
12	MP0005365_abnormal_bile_salt	2.51086803
13	MP0003718_maternal_effect	2.38170437
14	MP0002277_abnormal_respiratory_mucosa	2.22647095
15	MP0005408_hypopigmentation	2.15255640
16	MP0004019_abnormal_vitamin_homeostasis	2.14033213
17	MP0001666_abnormal_nutrient_absorption	2.09463632
18	MP0010386_abnormal_urinary_bladder	2.09013922
19	MP0005379_endocrine/exocrine_gland_phen	2.04499554
20	MP0003786_premature_aging	1.98066292
21	MP0008004_abnormal_stomach_pH	1.96061132
22	MP0005085_abnormal_gallbladder_physiolo	1.90006176
23	MP0003136_yellow_coat_color	1.89304197
24	MP0000569_abnormal_digit_pigmentation	1.86383830
25	MP0003693_abnormal_embryo_hatching	1.64334641
26	MP0001873_stomach_inflammation	1.63769307
27	MP0009840_abnormal_foam_cell	1.63115303
28	MP0005410_abnormal_fertilization	1.59846647
29	MP0005220_abnormal_exocrine_pancreas	1.54267335
30	MP0002638_abnormal_pupillary_reflex	1.49606401
31	MP0005636_abnormal_mineral_homeostasis	1.48057829
32	MP0005647_abnormal_sex_gland	1.46157979
33	MP0000613_abnormal_salivary_gland	1.46156496
34	MP0004885_abnormal_endolymph	1.44317880
35	MP0000647_abnormal_sebaceous_gland	1.39350326
36	MP0001346_abnormal_lacrimal_gland	1.32948966
37	MP0008058_abnormal_DNA_repair	1.32536265
38	MP0003195_calcinosis	1.28927142
39	MP0000383_abnormal_hair_follicle	1.28256143
40	MP0006035_abnormal_mitochondrial_morpho	1.27221279
41	MP0003806_abnormal_nucleotide_metabolis	1.20242300
42	MP0004264_abnormal_extraembryonic_tissu	1.20092337
43	MP0001485_abnormal_pinna_reflex	1.19919411
44	MP0010329_abnormal_lipoprotein_level	1.17870131
45	MP0003646_muscle_fatigue	1.15301561
46	MP0004133_heterotaxia	1.15228227
47	MP0002210_abnormal_sex_determination	1.14767195
48	MP0006036_abnormal_mitochondrial_physio	1.13479314
49	MP0000372_irregular_coat_pigmentation	1.12762385
50	MP0005084_abnormal_gallbladder_morpholo	1.12648886
51	MP0000427_abnormal_hair_cycle	1.11539113
52	MP0001348_abnormal_lacrimal_gland	1.09355021
53	MP0002938_white_spotting	1.09329052
54	MP0005174_abnormal_tail_pigmentation	1.08240255
55	MP0004782_abnormal_surfactant_physiolog	1.06423939
56	MP0001929_abnormal_gametogenesis	1.06236139
57	MP0006292_abnormal_olfactory_placode	1.05925072
58	MP0001944_abnormal_pancreas_morphology	1.05676712
59	MP0003890_abnormal_embryonic-extraembry	1.04281908
60	MP0009780_abnormal_chondrocyte_physiolo	1.03839764
61	MP0005332_abnormal_amino_acid	1.02823786
62	MP0001765_abnormal_ion_homeostasis	1.02448605
63	MP0005058_abnormal_lysosome_morphology	1.00021935
64	MP0002098_abnormal_vibrissa_morphology	0.99461574
65	MP0002132_abnormal_respiratory_system	0.99061022
66	MP0004147_increased_porphyrin_level	0.98359369
67	MP0000467_abnormal_esophagus_morphology	0.94909138
68	MP0010094_abnormal_chromosome_stability	0.92685790
69	MP0005310_abnormal_salivary_gland	0.92168217
70	MP0002796_impaired_skin_barrier	0.90812974
71	MP0005670_abnormal_white_adipose	0.90807212
72	MP0004957_abnormal_blastocyst_morpholog	0.90494043
73	MP0010678_abnormal_skin_adnexa	0.90417211
74	MP0001756_abnormal_urination	0.89579755
75	MP0003950_abnormal_plasma_membrane	0.89185304
76	MP0001145_abnormal_male_reproductive	0.88126492
77	MP0008875_abnormal_xenobiotic_pharmacok	0.88055090
78	MP0005395_other_phenotype	0.87894840
79	MP0003011_delayed_dark_adaptation	0.86014711
80	MP0004381_abnormal_hair_follicle	0.85591015
81	MP0001968_abnormal_touch/_nociception	0.85078658
82	MP0000470_abnormal_stomach_morphology	0.84666547
83	MP0003868_abnormal_feces_composition	0.84217658
84	MP0000653_abnormal_sex_gland	0.84076029
85	MP0000358_abnormal_cell_content/	0.83874842
86	MP0002089_abnormal_postnatal_growth/wei	0.81795258
87	MP0005360_urolithiasis	0.78949248
88	MP0002837_dystrophic_cardiac_calcinosis	0.77502746
89	MP0003699_abnormal_female_reproductive	0.77109014
90	MP0002909_abnormal_adrenal_gland	0.76834098
91	MP0009643_abnormal_urine_homeostasis	0.74581904
92	MP0005075_abnormal_melanosome_morpholog	0.73815905
93	MP0005389_reproductive_system_phenotype	0.73624133
94	MP0003300_gastrointestinal_ulcer	0.70888583
95	MP0002653_abnormal_ependyma_morphology	0.70320362
96	MP0003698_abnormal_male_reproductive	0.69535386
97	MP0005646_abnormal_pituitary_gland	0.68299577
98	MP0002736_abnormal_nociception_after	0.67812629
99	MP0002160_abnormal_reproductive_system	0.65417027
100	MP0003252_abnormal_bile_duct	0.63229735

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased circulating renin level (HP:0000848)	6.13422365
2	Bilateral sensorineural hearing impairment (HP:0008619)	5.98570200
3	Amelogenesis imperfecta (HP:0000705)	4.75514109
4	Hypomagnesemia (HP:0002917)	4.58919977
5	Hypokalemic alkalosis (HP:0001949)	4.04638423
6	Abnormality of magnesium homeostasis (HP:0004921)	4.00652637
7	Tetany (HP:0001281)	3.95946799
8	Polydipsia (HP:0001959)	3.59394204
9	Abnormal drinking behavior (HP:0030082)	3.59394204
10	Male infertility (HP:0003251)	3.53628775
11	Ileus (HP:0002595)	3.49646847
12	Renal tubular acidosis (HP:0001947)	3.36879773
13	Abnormality of dental color (HP:0011073)	3.35536409
14	Abnormality of renin-angiotensin system (HP:0000847)	3.19211003
15	Paralysis (HP:0003470)	3.07134112
16	Hypoplasia of the uterus (HP:0000013)	3.00838149
17	Abnormal pancreas size (HP:0012094)	2.99662642
18	Renal tubular dysfunction (HP:0000124)	2.71985904
19	Pendular nystagmus (HP:0012043)	2.66780543
20	Severe visual impairment (HP:0001141)	2.66608537
21	Aplasia/hypoplasia of the uterus (HP:0008684)	2.65775071
22	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.65239638
23	Parakeratosis (HP:0001036)	2.59461767
24	Polyuria (HP:0000103)	2.58741139
25	Azoospermia (HP:0000027)	2.57908313
26	Exocrine pancreatic insufficiency (HP:0001738)	2.55337968
27	Methylmalonic acidemia (HP:0002912)	2.49337714
28	Proximal tubulopathy (HP:0000114)	2.47461153
29	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.46182450
30	Glycosuria (HP:0003076)	2.43578982
31	Abnormality of urine glucose concentration (HP:0011016)	2.43578982
32	Acute necrotizing encephalopathy (HP:0006965)	2.40180139
33	Methylmalonic aciduria (HP:0012120)	2.37159833
34	Abnormality of the dental pulp (HP:0006479)	2.36569131
35	Abnormality of renal excretion (HP:0011036)	2.34447889
36	Acute encephalopathy (HP:0006846)	2.29700681
37	Osteomalacia (HP:0002749)	2.27236077
38	Increased CSF lactate (HP:0002490)	2.26490949
39	Small epiphyses (HP:0010585)	2.21939229
40	Alkalosis (HP:0001948)	2.20971314
41	Hyperglycinemia (HP:0002154)	2.20173736
42	Vacuolated lymphocytes (HP:0001922)	2.15210876
43	Gout (HP:0001997)	2.14852639
44	Abnormal urine output (HP:0012590)	2.13073502
45	Abnormal mitochondria in muscle tissue (HP:0008316)	2.11392364
46	Abnormality of vitamin B metabolism (HP:0004340)	2.11229107
47	Hypokinesia (HP:0002375)	2.10104827
48	Renal Fanconi syndrome (HP:0001994)	2.09582790
49	Vascular calcification (HP:0004934)	2.08038034
50	Carpal bone hypoplasia (HP:0001498)	2.07893482
51	Asplenia (HP:0001746)	2.07518216
52	Hypokalemia (HP:0002900)	2.07165223
53	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.05832307
54	Abnormality of the dental root (HP:0006486)	2.04967086
55	Taurodontia (HP:0000679)	2.04967086
56	Abnormality of permanent molar morphology (HP:0011071)	2.04967086
57	Hypophosphatemic rickets (HP:0004912)	2.04546406
58	Severe muscular hypotonia (HP:0006829)	2.02417219
59	Abnormal biliary tract morphology (HP:0012440)	1.98853414
60	Abnormality of renal resorption (HP:0011038)	1.98775775
61	High anterior hairline (HP:0009890)	1.98547379
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.97412396
63	Abnormality of molar morphology (HP:0011070)	1.96621563
64	Abnormality of molar (HP:0011077)	1.96621563
65	Mitochondrial inheritance (HP:0001427)	1.94958209
66	Progressive macrocephaly (HP:0004481)	1.94635278
67	Right ventricular cardiomyopathy (HP:0011663)	1.93654482
68	Abnormality of vitamin metabolism (HP:0100508)	1.92749692
69	Pancreatic cysts (HP:0001737)	1.92459141
70	Type I diabetes mellitus (HP:0100651)	1.91743899
71	Cerebellar dysplasia (HP:0007033)	1.90258055
72	Double outlet right ventricle (HP:0001719)	1.89570077
73	Congenital malformation of the right heart (HP:0011723)	1.89570077
74	Abnormality of Sharpey fibers (HP:0100685)	1.85514980
75	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.84858546
76	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.84858546
77	Abnormality of midbrain morphology (HP:0002418)	1.84739614
78	Molar tooth sign on MRI (HP:0002419)	1.84739614
79	Cone-rod dystrophy (HP:0000548)	1.84306897
80	Short hallux (HP:0010109)	1.81083870
81	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.80663265
82	Hypoplasia of the fovea (HP:0007750)	1.80663265
83	Hypercortisolism (HP:0001578)	1.80570636
84	Fragile nails (HP:0001808)	1.79042961
85	Nephrocalcinosis (HP:0000121)	1.78787850
86	Abnormal rod and cone electroretinograms (HP:0008323)	1.76849550
87	Chondrocalcinosis (HP:0000934)	1.75341130
88	Abnormality of glycine metabolism (HP:0010895)	1.74690579
89	Abnormality of serine family amino acid metabolism (HP:0010894)	1.74690579
90	Abnormal biliary tract physiology (HP:0012439)	1.74097048
91	Bile duct proliferation (HP:0001408)	1.74097048
92	Woolly hair (HP:0002224)	1.73530989
93	Sparse eyelashes (HP:0000653)	1.71195300
94	Abnormality of the pons (HP:0007361)	1.70463157
95	Conical tooth (HP:0000698)	1.69997418
96	Stenosis of the external auditory canal (HP:0000402)	1.68846085
97	Hyperphosphaturia (HP:0003109)	1.68765508
98	Type II lissencephaly (HP:0007260)	1.68043183
99	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.67604075
100	Hydroxyprolinuria (HP:0003080)	1.66594099

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK39	7.64498160
2	WNK4	7.12959894
3	OXSR1	5.87051409
4	LMTK2	5.18274997
5	EIF2AK3	2.95118105
6	MST4	2.69192487
7	MUSK	2.42068814
8	TNIK	2.23485365
9	BMPR1B	2.15303175
10	PBK	2.04045000
11	MAP3K12	1.73282502
12	VRK2	1.51907378
13	EPHA2	1.47183880
14	EIF2AK1	1.41339294
15	PDK2	1.37833979
16	PRKG2	1.36577280
17	STK24	1.31685939
18	STK38L	1.20477350
19	GRK1	1.16364601
20	NLK	1.16363843
21	ACVR1B	1.13081483
22	FRK	1.13036140
23	BUB1	1.03404193
24	MAP3K6	0.97997884
25	PINK1	0.96415186
26	NME1	0.96407078
27	PAK3	0.95090147
28	PRKCI	0.93310024
29	MAP2K7	0.87103729
30	ADRBK2	0.86703886
31	MAP4K2	0.84230413
32	PRKD3	0.83742420
33	CAMK1D	0.75299331
34	PLK2	0.73174013
35	ZAK	0.73149620
36	MYLK	0.72219735
37	CAMKK2	0.70344105
38	PHKG2	0.70263327
39	PHKG1	0.70263327
40	STK16	0.67127540
41	TAOK3	0.65770194
42	PRKCE	0.63509242
43	WNK3	0.63162484
44	NUAK1	0.62053318
45	LIMK1	0.58387032
46	NEK1	0.57830388
47	TLK1	0.56564967
48	INSRR	0.55860474
49	FER	0.54171494
50	TRIM28	0.53372803
51	RPS6KB2	0.52307432
52	MAPKAPK3	0.51918383
53	PLK1	0.50279471
54	MAP2K6	0.48099557
55	TGFBR1	0.44050029
56	MKNK2	0.42308972
57	STK3	0.42139556
58	AURKA	0.41952673
59	EIF2AK2	0.41124379
60	BRD4	0.39482526
61	DAPK1	0.39217884
62	MAP3K9	0.37344795
63	STK10	0.37223010
64	ILK	0.35404946
65	VRK1	0.33048459
66	IKBKB	0.32343644
67	NEK6	0.31635384
68	PAK4	0.30983260
69	MAP3K4	0.30921037
70	WEE1	0.28227199
71	STK4	0.27871761
72	PRKCQ	0.27633459
73	PTK2	0.26825398
74	CSNK1G1	0.26705543
75	PLK3	0.26658019
76	AKT2	0.26462326
77	PRKCG	0.26332863
78	BRSK2	0.25992686
79	CSNK2A1	0.25900249
80	PIK3CA	0.25268315
81	CHEK2	0.25022031
82	CAMK2D	0.25002983
83	AURKB	0.24471697
84	ADRBK1	0.24233634
85	CHUK	0.23948710
86	STK38	0.23719771
87	FGFR1	0.23534019
88	PLK4	0.22934031
89	ATM	0.22107064
90	ROCK1	0.21173945
91	MAP3K5	0.21161317
92	PRKAA1	0.21069532
93	ABL2	0.20958291
94	PRKAA2	0.20940941
95	MELK	0.20754659
96	MARK3	0.20218072
97	DAPK3	0.19502839
98	NME2	0.17291681
99	TAOK1	0.16554446
100	BMX	0.16550983

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Collecting duct acid secretion_Homo sapiens_hsa04966	3.69120199
2	Proteasome_Homo sapiens_hsa03050	3.28344653
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.05430484
4	Protein export_Homo sapiens_hsa03060	2.92096984
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.45678635
6	Vibrio cholerae infection_Homo sapiens_hsa05110	2.37045726
7	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.36457541
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.35558004
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.20549288
10	Basal transcription factors_Homo sapiens_hsa03022	1.99694014
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.95228808
12	RNA polymerase_Homo sapiens_hsa03020	1.93299894
13	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.90613402
14	Folate biosynthesis_Homo sapiens_hsa00790	1.88659398
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.74489864
16	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.69752900
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.63908986
18	Glutathione metabolism_Homo sapiens_hsa00480	1.55286057
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.47836625
20	Fatty acid elongation_Homo sapiens_hsa00062	1.43821832
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.42451021
22	Parkinsons disease_Homo sapiens_hsa05012	1.40919786
23	Butanoate metabolism_Homo sapiens_hsa00650	1.38488869
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34122330
25	Caffeine metabolism_Homo sapiens_hsa00232	1.33646604
26	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.32893094
27	Sulfur metabolism_Homo sapiens_hsa00920	1.30824999
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.27624522
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.27249209
30	Sphingolipid metabolism_Homo sapiens_hsa00600	1.26697742
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24876870
32	Lysosome_Homo sapiens_hsa04142	1.24517435
33	RNA transport_Homo sapiens_hsa03013	1.24363916
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.24286430
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.24144863
36	Fat digestion and absorption_Homo sapiens_hsa04975	1.23290104
37	One carbon pool by folate_Homo sapiens_hsa00670	1.20053823
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.19969554
39	Huntingtons disease_Homo sapiens_hsa05016	1.19878293
40	Circadian rhythm_Homo sapiens_hsa04710	1.12106774
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.08789348
42	Phototransduction_Homo sapiens_hsa04744	1.08271990
43	RNA degradation_Homo sapiens_hsa03018	1.08137652
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08133491
45	Ribosome_Homo sapiens_hsa03010	1.07684617
46	Mineral absorption_Homo sapiens_hsa04978	1.05443169
47	Homologous recombination_Homo sapiens_hsa03440	1.02595430
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98717480
49	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.98316218
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.98264021
51	Pancreatic secretion_Homo sapiens_hsa04972	0.96690048
52	ABC transporters_Homo sapiens_hsa02010	0.96592607
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95676948
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.93654405
55	Peroxisome_Homo sapiens_hsa04146	0.93378148
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92223751
57	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.92119736
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91737105
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91329551
60	Metabolic pathways_Homo sapiens_hsa01100	0.91236013
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91113041
62	Bile secretion_Homo sapiens_hsa04976	0.89373385
63	Regulation of autophagy_Homo sapiens_hsa04140	0.87191629
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87158466
65	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.86927200
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.84275027
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.82758152
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.80418231
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.78288347
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.77551548
71	Steroid biosynthesis_Homo sapiens_hsa00100	0.75853551
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.75726421
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.75588986
74	Tryptophan metabolism_Homo sapiens_hsa00380	0.74848779
75	Retinol metabolism_Homo sapiens_hsa00830	0.72751977
76	Tight junction_Homo sapiens_hsa04530	0.71654217
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70325350
78	Propanoate metabolism_Homo sapiens_hsa00640	0.69508283
79	Olfactory transduction_Homo sapiens_hsa04740	0.66775122
80	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.66637641
81	Other glycan degradation_Homo sapiens_hsa00511	0.64553652
82	Mismatch repair_Homo sapiens_hsa03430	0.64158282
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61113364
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.59220677
85	Protein digestion and absorption_Homo sapiens_hsa04974	0.58877755
86	Alzheimers disease_Homo sapiens_hsa05010	0.57745708
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57729389
88	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.57647443
89	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57525598
90	mRNA surveillance pathway_Homo sapiens_hsa03015	0.55105602
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54107370
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.53511727
93	Purine metabolism_Homo sapiens_hsa00230	0.50952863
94	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.48528423
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45124733
96	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.43123740
97	Spliceosome_Homo sapiens_hsa03040	0.42212227
98	Galactose metabolism_Homo sapiens_hsa00052	0.41193554
99	DNA replication_Homo sapiens_hsa03030	0.38987633
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.38438630

FTLP14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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