

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ATP synthesis coupled proton transport (GO:0015986) | 7.48595623 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 7.48595623 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 6.30747820 |
| 4 | ribosome assembly (GO:0042255) | 6.06514628 |
| 5 | oxygen transport (GO:0015671) | 6.04434405 |
| 6 | muscle organ morphogenesis (GO:0048644) | 6.01091218 |
| 7 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.00502123 |
| 8 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 5.96448023 |
| 9 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 5.96448023 |
| 10 | NADH dehydrogenase complex assembly (GO:0010257) | 5.96448023 |
| 11 | protein complex biogenesis (GO:0070271) | 5.96358007 |
| 12 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 5.81081709 |
| 13 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.73112323 |
| 14 | ribosomal small subunit assembly (GO:0000028) | 5.71114207 |
| 15 | respiratory chain complex IV assembly (GO:0008535) | 5.63600656 |
| 16 | ribosomal small subunit biogenesis (GO:0042274) | 5.51149708 |
| 17 | mitochondrial respiratory chain complex assembly (GO:0033108) | 5.47671542 |
| 18 | chaperone-mediated protein transport (GO:0072321) | 5.39495287 |
| 19 | response to dietary excess (GO:0002021) | 5.29084541 |
| 20 | respiratory electron transport chain (GO:0022904) | 5.00254933 |
| 21 | positive regulation of vesicle fusion (GO:0031340) | 4.93965918 |
| 22 | electron transport chain (GO:0022900) | 4.92408163 |
| 23 | gas transport (GO:0015669) | 4.85580091 |
| 24 | cytochrome complex assembly (GO:0017004) | 4.84281541 |
| 25 | intracellular protein transmembrane import (GO:0044743) | 4.71455142 |
| 26 | protein targeting to mitochondrion (GO:0006626) | 4.53816602 |
| 27 | DNA deamination (GO:0045006) | 4.51555320 |
| 28 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.47236630 |
| 29 | termination of RNA polymerase III transcription (GO:0006386) | 4.47236630 |
| 30 | protein neddylation (GO:0045116) | 4.45145381 |
| 31 | cullin deneddylation (GO:0010388) | 4.43227139 |
| 32 | proteasome assembly (GO:0043248) | 4.41843403 |
| 33 | peptidyl-histidine modification (GO:0018202) | 4.40831377 |
| 34 | establishment of protein localization to mitochondrion (GO:0072655) | 4.35142545 |
| 35 | viral transcription (GO:0019083) | 4.30874034 |
| 36 | maturation of 5.8S rRNA (GO:0000460) | 4.27921066 |
| 37 | ATP biosynthetic process (GO:0006754) | 4.27632890 |
| 38 | translational termination (GO:0006415) | 4.27044426 |
| 39 | protein-cofactor linkage (GO:0018065) | 4.19144615 |
| 40 | maturation of SSU-rRNA (GO:0030490) | 4.19048547 |
| 41 | pseudouridine synthesis (GO:0001522) | 4.09532779 |
| 42 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.08226725 |
| 43 | cotranslational protein targeting to membrane (GO:0006613) | 3.98636982 |
| 44 | protein targeting to ER (GO:0045047) | 3.98598271 |
| 45 | protein localization to mitochondrion (GO:0070585) | 3.97609196 |
| 46 | transcription from mitochondrial promoter (GO:0006390) | 3.94535577 |
| 47 | protein localization to endoplasmic reticulum (GO:0070972) | 3.87922057 |
| 48 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.86073902 |
| 49 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.85851606 |
| 50 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.85733759 |
| 51 | rRNA modification (GO:0000154) | 3.81719094 |
| 52 | autophagic vacuole fusion (GO:0000046) | 3.79416938 |
| 53 | protein deneddylation (GO:0000338) | 3.70098809 |
| 54 | protein transmembrane transport (GO:0071806) | 3.68884346 |
| 55 | translational elongation (GO:0006414) | 3.65298099 |
| 56 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.60986152 |
| 57 | short-chain fatty acid metabolic process (GO:0046459) | 3.59031570 |
| 58 | translation (GO:0006412) | 3.58044885 |
| 59 | intracellular protein transmembrane transport (GO:0065002) | 3.56486638 |
| 60 | hydrogen ion transmembrane transport (GO:1902600) | 3.44608925 |
| 61 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.43760207 |
| 62 | inner mitochondrial membrane organization (GO:0007007) | 3.43313572 |
| 63 | positive regulation of prostaglandin secretion (GO:0032308) | 3.39944723 |
| 64 | cellular component biogenesis (GO:0044085) | 3.39575140 |
| 65 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.34230411 |
| 66 | cellular protein complex disassembly (GO:0043624) | 3.29159885 |
| 67 | cellular respiration (GO:0045333) | 3.29020847 |
| 68 | translational initiation (GO:0006413) | 3.27795569 |
| 69 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.26893118 |
| 70 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 3.26161954 |
| 71 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.22789820 |
| 72 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.22789820 |
| 73 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.22752036 |
| 74 | proton transport (GO:0015992) | 3.21978432 |
| 75 | positive regulation of sodium ion transmembrane transporter activity (GO:2000651) | 3.20041772 |
| 76 | platelet dense granule organization (GO:0060155) | 3.18941009 |
| 77 | viral life cycle (GO:0019058) | 3.18485055 |
| 78 | organelle membrane fusion (GO:0090174) | 3.17907020 |
| 79 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.16782663 |
| 80 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.16782663 |
| 81 | mitochondrial transport (GO:0006839) | 3.16031093 |
| 82 | hydrogen transport (GO:0006818) | 3.13003548 |
| 83 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 3.12512158 |
| 84 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.10320531 |
| 85 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.10320531 |
| 86 | positive regulation of sodium ion transmembrane transport (GO:1902307) | 3.10007947 |
| 87 | iron-sulfur cluster assembly (GO:0016226) | 3.06388856 |
| 88 | metallo-sulfur cluster assembly (GO:0031163) | 3.06388856 |
| 89 | positive regulation of icosanoid secretion (GO:0032305) | 3.02570639 |
| 90 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.99831556 |
| 91 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.99271813 |
| 92 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.98466339 |
| 93 | myoblast migration (GO:0051451) | 2.97591726 |
| 94 | GMP metabolic process (GO:0046037) | 2.96160087 |
| 95 | S-adenosylmethionine metabolic process (GO:0046500) | 2.94717927 |
| 96 | deoxyribonucleotide catabolic process (GO:0009264) | 2.93003371 |
| 97 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.90585513 |
| 98 | C-terminal protein lipidation (GO:0006501) | 2.90513341 |
| 99 | oxidative phosphorylation (GO:0006119) | 2.89151629 |
| 100 | cellular response to ATP (GO:0071318) | 2.88954411 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.67112445 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.53601664 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.52505611 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.19130814 |
| 5 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 4.11707114 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.79499960 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.70907794 |
| 8 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 3.24750717 |
| 9 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.12217690 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.07018293 |
| 11 | VDR_23849224_ChIP-Seq_CD4+_Human | 3.02285004 |
| 12 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.88200580 |
| 13 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.75634043 |
| 14 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.70916209 |
| 15 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.70418694 |
| 16 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.54159569 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.52480490 |
| 18 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.51410133 |
| 19 | VDR_22108803_ChIP-Seq_LS180_Human | 2.47789407 |
| 20 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.42695480 |
| 21 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.42192527 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.33434049 |
| 23 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.31874484 |
| 24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.30831079 |
| 25 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.27546458 |
| 26 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.19210147 |
| 27 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 2.17751790 |
| 28 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.16785221 |
| 29 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.02881970 |
| 30 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.97265460 |
| 31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.94136191 |
| 32 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.83472251 |
| 33 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.78293814 |
| 34 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.72125902 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.69477806 |
| 36 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.68490320 |
| 37 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.59799860 |
| 38 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.59566782 |
| 39 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.54986268 |
| 40 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.48195292 |
| 41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.46527386 |
| 42 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.43447393 |
| 43 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.42477910 |
| 44 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.40294743 |
| 45 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.37080671 |
| 46 | EWS_26573619_Chip-Seq_HEK293_Human | 1.35679575 |
| 47 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.31605373 |
| 48 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.25971470 |
| 49 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.25167374 |
| 50 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.23933585 |
| 51 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.17892383 |
| 52 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.16650119 |
| 53 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16450860 |
| 54 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.16096006 |
| 55 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.13814092 |
| 56 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.13814092 |
| 57 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.12990391 |
| 58 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.09495840 |
| 59 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.09160742 |
| 60 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.08448156 |
| 61 | AR_20517297_ChIP-Seq_VCAP_Human | 1.07005005 |
| 62 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.04009018 |
| 63 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.04004033 |
| 64 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.03523298 |
| 65 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.03018301 |
| 66 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.02839722 |
| 67 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.01996406 |
| 68 | FUS_26573619_Chip-Seq_HEK293_Human | 1.01915749 |
| 69 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.01672555 |
| 70 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.01506565 |
| 71 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.98927803 |
| 72 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.98704574 |
| 73 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.97536237 |
| 74 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 0.96385623 |
| 75 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.93837604 |
| 76 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.93651762 |
| 77 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.90895661 |
| 78 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.90556434 |
| 79 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.88741497 |
| 80 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.88487856 |
| 81 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.87667213 |
| 82 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.86010952 |
| 83 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.85744725 |
| 84 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.83947220 |
| 85 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.82844995 |
| 86 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.82596155 |
| 87 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.80969712 |
| 88 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.80346618 |
| 89 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.79008903 |
| 90 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.78728120 |
| 91 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.78216771 |
| 92 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.77477377 |
| 93 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.76557502 |
| 94 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.76101513 |
| 95 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.73914367 |
| 96 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.73914367 |
| 97 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.73914367 |
| 98 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.73429862 |
| 99 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.72316867 |
| 100 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.72035969 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000372_irregular_coat_pigmentation | 7.51625100 |
| 2 | MP0004145_abnormal_muscle_electrophysio | 6.36571101 |
| 3 | MP0004885_abnormal_endolymph | 3.58323739 |
| 4 | MP0001188_hyperpigmentation | 3.36248256 |
| 5 | MP0003806_abnormal_nucleotide_metabolis | 3.22157626 |
| 6 | MP0000749_muscle_degeneration | 3.14394823 |
| 7 | MP0003941_abnormal_skin_development | 2.73117235 |
| 8 | MP0004270_analgesia | 2.63365400 |
| 9 | MP0006036_abnormal_mitochondrial_physio | 2.55298862 |
| 10 | MP0003186_abnormal_redox_activity | 2.54175389 |
| 11 | MP0002837_dystrophic_cardiac_calcinosis | 2.46052414 |
| 12 | MP0005646_abnormal_pituitary_gland | 2.42692884 |
| 13 | MP0004147_increased_porphyrin_level | 2.35445545 |
| 14 | MP0001661_extended_life_span | 2.33729941 |
| 15 | MP0009046_muscle_twitch | 2.05575339 |
| 16 | MP0005075_abnormal_melanosome_morpholog | 2.04315499 |
| 17 | MP0003656_abnormal_erythrocyte_physiolo | 2.00593047 |
| 18 | MP0003950_abnormal_plasma_membrane | 1.94980133 |
| 19 | MP0003136_yellow_coat_color | 1.94186986 |
| 20 | MP0003011_delayed_dark_adaptation | 1.93650005 |
| 21 | MP0000747_muscle_weakness | 1.84936722 |
| 22 | MP0003693_abnormal_embryo_hatching | 1.74981001 |
| 23 | MP0001986_abnormal_taste_sensitivity | 1.73856307 |
| 24 | MP0002234_abnormal_pharynx_morphology | 1.69498565 |
| 25 | MP0000750_abnormal_muscle_regeneration | 1.69070011 |
| 26 | MP0002163_abnormal_gland_morphology | 1.66812533 |
| 27 | MP0006292_abnormal_olfactory_placode | 1.62120676 |
| 28 | MP0003786_premature_aging | 1.51751699 |
| 29 | MP0002138_abnormal_hepatobiliary_system | 1.44979390 |
| 30 | MP0008058_abnormal_DNA_repair | 1.41788050 |
| 31 | MP0004381_abnormal_hair_follicle | 1.41141880 |
| 32 | MP0002277_abnormal_respiratory_mucosa | 1.35805915 |
| 33 | MP0003195_calcinosis | 1.33048202 |
| 34 | MP0009379_abnormal_foot_pigmentation | 1.31840083 |
| 35 | MP0005377_hearing/vestibular/ear_phenot | 1.26199004 |
| 36 | MP0003878_abnormal_ear_physiology | 1.26199004 |
| 37 | MP0006035_abnormal_mitochondrial_morpho | 1.23419339 |
| 38 | MP0003137_abnormal_impulse_conducting | 1.13922240 |
| 39 | MP0002269_muscular_atrophy | 1.11307402 |
| 40 | MP0004043_abnormal_pH_regulation | 1.10674924 |
| 41 | MP0000516_abnormal_urinary_system | 1.07045846 |
| 42 | MP0005367_renal/urinary_system_phenotyp | 1.07045846 |
| 43 | MP0005084_abnormal_gallbladder_morpholo | 1.02421682 |
| 44 | MP0002139_abnormal_hepatobiliary_system | 1.00047947 |
| 45 | MP0001299_abnormal_eye_distance/ | 1.00037658 |
| 46 | MP0002638_abnormal_pupillary_reflex | 0.99972854 |
| 47 | MP0000759_abnormal_skeletal_muscle | 0.99786708 |
| 48 | MP0005220_abnormal_exocrine_pancreas | 0.99432065 |
| 49 | MP0002876_abnormal_thyroid_physiology | 0.98899720 |
| 50 | MP0005636_abnormal_mineral_homeostasis | 0.97894010 |
| 51 | MP0002938_white_spotting | 0.97331120 |
| 52 | MP0004142_abnormal_muscle_tone | 0.96701004 |
| 53 | MP0001486_abnormal_startle_reflex | 0.96191204 |
| 54 | MP0002132_abnormal_respiratory_system | 0.95251913 |
| 55 | MP0003718_maternal_effect | 0.95101792 |
| 56 | MP0008875_abnormal_xenobiotic_pharmacok | 0.93264157 |
| 57 | MP0002933_joint_inflammation | 0.90337202 |
| 58 | MP0002160_abnormal_reproductive_system | 0.90110878 |
| 59 | MP0003567_abnormal_fetal_cardiomyocyte | 0.89466345 |
| 60 | MP0000631_abnormal_neuroendocrine_gland | 0.88580905 |
| 61 | MP0006072_abnormal_retinal_apoptosis | 0.86196127 |
| 62 | MP0004215_abnormal_myocardial_fiber | 0.85845200 |
| 63 | MP0000681_abnormal_thyroid_gland | 0.84763605 |
| 64 | MP0001764_abnormal_homeostasis | 0.81937376 |
| 65 | MP0009333_abnormal_splenocyte_physiolog | 0.80705481 |
| 66 | MP0009765_abnormal_xenobiotic_induced | 0.80124047 |
| 67 | MP0000569_abnormal_digit_pigmentation | 0.79852961 |
| 68 | MP0005332_abnormal_amino_acid | 0.79355142 |
| 69 | MP0002734_abnormal_mechanical_nocicepti | 0.78192248 |
| 70 | MP0001485_abnormal_pinna_reflex | 0.76914478 |
| 71 | MP0002736_abnormal_nociception_after | 0.75683703 |
| 72 | MP0009697_abnormal_copulation | 0.74592263 |
| 73 | MP0001542_abnormal_bone_strength | 0.73918685 |
| 74 | MP0005379_endocrine/exocrine_gland_phen | 0.72693815 |
| 75 | MP0002177_abnormal_outer_ear | 0.72518269 |
| 76 | MP0001905_abnormal_dopamine_level | 0.71871404 |
| 77 | MP0003646_muscle_fatigue | 0.71512436 |
| 78 | MP0003279_aneurysm | 0.71248880 |
| 79 | MP0001529_abnormal_vocalization | 0.68516986 |
| 80 | MP0005253_abnormal_eye_physiology | 0.67313847 |
| 81 | MP0001186_pigmentation_phenotype | 0.64046311 |
| 82 | MP0000015_abnormal_ear_pigmentation | 0.63958753 |
| 83 | MP0010030_abnormal_orbit_morphology | 0.63189945 |
| 84 | MP0001881_abnormal_mammary_gland | 0.63188541 |
| 85 | MP0001968_abnormal_touch/_nociception | 0.63065023 |
| 86 | MP0009250_abnormal_appendicular_skeleto | 0.59349333 |
| 87 | MP0002106_abnormal_muscle_physiology | 0.59206774 |
| 88 | MP0004233_abnormal_muscle_weight | 0.58950922 |
| 89 | MP0005058_abnormal_lysosome_morphology | 0.58780099 |
| 90 | MP0000733_abnormal_muscle_development | 0.56240883 |
| 91 | MP0005389_reproductive_system_phenotype | 0.54884514 |
| 92 | MP0001963_abnormal_hearing_physiology | 0.54563389 |
| 93 | MP0005410_abnormal_fertilization | 0.54315442 |
| 94 | MP0002095_abnormal_skin_pigmentation | 0.53737367 |
| 95 | MP0003252_abnormal_bile_duct | 0.52516576 |
| 96 | MP0000343_altered_response_to | 0.50156373 |
| 97 | MP0001984_abnormal_olfaction | 0.49966188 |
| 98 | MP0002102_abnormal_ear_morphology | 0.48823535 |
| 99 | MP0001191_abnormal_skin_condition | 0.48751448 |
| 100 | MP0005369_muscle_phenotype | 0.48664074 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Type 2 muscle fiber atrophy (HP:0003554) | 8.87694058 |
| 2 | Muscle fiber atrophy (HP:0100295) | 7.91346671 |
| 3 | Abnormality of the neuromuscular junction (HP:0003398) | 6.01828986 |
| 4 | Fatigable weakness (HP:0003473) | 6.01828986 |
| 5 | Weak cry (HP:0001612) | 4.86299742 |
| 6 | Acute necrotizing encephalopathy (HP:0006965) | 4.86162928 |
| 7 | Acute encephalopathy (HP:0006846) | 4.74710013 |
| 8 | Mitochondrial inheritance (HP:0001427) | 4.52634912 |
| 9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.43507769 |
| 10 | Increased CSF lactate (HP:0002490) | 4.40172282 |
| 11 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 4.35687791 |
| 12 | Hepatocellular necrosis (HP:0001404) | 4.33435638 |
| 13 | Progressive macrocephaly (HP:0004481) | 4.33350238 |
| 14 | Hepatic necrosis (HP:0002605) | 4.28354287 |
| 15 | Easy fatigability (HP:0003388) | 4.23518509 |
| 16 | Nonprogressive disorder (HP:0003680) | 3.85577895 |
| 17 | Methylmalonic acidemia (HP:0002912) | 3.55857342 |
| 18 | Abnormality of placental membranes (HP:0011409) | 3.53251035 |
| 19 | Amniotic constriction ring (HP:0009775) | 3.53251035 |
| 20 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.39603420 |
| 21 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.39603420 |
| 22 | Lipid accumulation in hepatocytes (HP:0006561) | 3.35323647 |
| 23 | Increased hepatocellular lipid droplets (HP:0006565) | 3.22391583 |
| 24 | Decreased muscle mass (HP:0003199) | 3.21854098 |
| 25 | Popliteal pterygium (HP:0009756) | 3.21536683 |
| 26 | Abnormal hemoglobin (HP:0011902) | 3.20447088 |
| 27 | Gowers sign (HP:0003391) | 3.14799561 |
| 28 | Bell-shaped thorax (HP:0001591) | 3.04449551 |
| 29 | Cerebral edema (HP:0002181) | 3.02365571 |
| 30 | Renal Fanconi syndrome (HP:0001994) | 2.99900651 |
| 31 | 3-Methylglutaconic aciduria (HP:0003535) | 2.81642972 |
| 32 | Increased intramyocellular lipid droplets (HP:0012240) | 2.81496492 |
| 33 | Respiratory failure (HP:0002878) | 2.78031023 |
| 34 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.77225595 |
| 35 | Respiratory difficulties (HP:0002880) | 2.68850711 |
| 36 | Renal cortical cysts (HP:0000803) | 2.62260974 |
| 37 | Increased muscle lipid content (HP:0009058) | 2.60478079 |
| 38 | Fibular aplasia (HP:0002990) | 2.57557773 |
| 39 | Increased serum lactate (HP:0002151) | 2.56895785 |
| 40 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 2.56137574 |
| 41 | Lactic acidosis (HP:0003128) | 2.54690361 |
| 42 | Methylmalonic aciduria (HP:0012120) | 2.49449812 |
| 43 | Nausea (HP:0002018) | 2.48853358 |
| 44 | Absent phalangeal crease (HP:0006109) | 2.47783976 |
| 45 | CNS demyelination (HP:0007305) | 2.46922105 |
| 46 | Abnormality of urine glucose concentration (HP:0011016) | 2.43732940 |
| 47 | Glycosuria (HP:0003076) | 2.43732940 |
| 48 | Aplasia of the musculature (HP:0100854) | 2.42701700 |
| 49 | Testicular atrophy (HP:0000029) | 2.39266560 |
| 50 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.36175924 |
| 51 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.36157668 |
| 52 | Generalized aminoaciduria (HP:0002909) | 2.35817856 |
| 53 | Optic disc pallor (HP:0000543) | 2.32152767 |
| 54 | Exercise intolerance (HP:0003546) | 2.30241850 |
| 55 | Fetal akinesia sequence (HP:0001989) | 2.29437518 |
| 56 | Abnormal number of erythroid precursors (HP:0012131) | 2.27820256 |
| 57 | Exertional dyspnea (HP:0002875) | 2.27753375 |
| 58 | Abnormality of the renal cortex (HP:0011035) | 2.26090110 |
| 59 | Microglossia (HP:0000171) | 2.25550801 |
| 60 | Delayed CNS myelination (HP:0002188) | 2.21485679 |
| 61 | Pallor (HP:0000980) | 2.20834897 |
| 62 | Redundant skin (HP:0001582) | 2.19858861 |
| 63 | Leukodystrophy (HP:0002415) | 2.18396627 |
| 64 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.06755941 |
| 65 | Alveolar cell carcinoma (HP:0006519) | 2.04732386 |
| 66 | Decreased central vision (HP:0007663) | 2.04696079 |
| 67 | Poor suck (HP:0002033) | 2.03079983 |
| 68 | Abnormal finger flexion creases (HP:0006143) | 2.01991116 |
| 69 | Absent eyebrow (HP:0002223) | 2.01524627 |
| 70 | Abnormality of vitamin B metabolism (HP:0004340) | 2.01031877 |
| 71 | Lethargy (HP:0001254) | 1.99235504 |
| 72 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.98465815 |
| 73 | Delayed gross motor development (HP:0002194) | 1.97346520 |
| 74 | Cutaneous melanoma (HP:0012056) | 1.96780572 |
| 75 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.94743353 |
| 76 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.93022245 |
| 77 | Adrenal hypoplasia (HP:0000835) | 1.92701794 |
| 78 | Wrist flexion contracture (HP:0001239) | 1.91156784 |
| 79 | Long clavicles (HP:0000890) | 1.90227334 |
| 80 | Emotional lability (HP:0000712) | 1.89889570 |
| 81 | Neoplasm of head and neck (HP:0012288) | 1.88911870 |
| 82 | Esophageal neoplasm (HP:0100751) | 1.88911870 |
| 83 | Submucous cleft hard palate (HP:0000176) | 1.88301210 |
| 84 | Hypoplasia of the uterus (HP:0000013) | 1.87393906 |
| 85 | Hypoplastic heart (HP:0001961) | 1.87307371 |
| 86 | Malignant hyperthermia (HP:0002047) | 1.87224450 |
| 87 | Brushfield spots (HP:0001088) | 1.81804503 |
| 88 | Irregular vertebral endplates (HP:0003301) | 1.81090808 |
| 89 | Pancreatic cysts (HP:0001737) | 1.80197551 |
| 90 | Hyperthyroidism (HP:0000836) | 1.71703735 |
| 91 | Abnormal glycosylation (HP:0012345) | 1.71160431 |
| 92 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.71160431 |
| 93 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.71160431 |
| 94 | Abnormal protein glycosylation (HP:0012346) | 1.71160431 |
| 95 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.69965330 |
| 96 | Dicarboxylic aciduria (HP:0003215) | 1.69965330 |
| 97 | Type I transferrin isoform profile (HP:0003642) | 1.66674221 |
| 98 | Neoplasm of the tracheobronchial system (HP:0100552) | 1.66162335 |
| 99 | Degeneration of anterior horn cells (HP:0002398) | 1.65631569 |
| 100 | Abnormality of the anterior horn cell (HP:0006802) | 1.65631569 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | AKT3 | 4.54201999 |
| 2 | NME2 | 2.86250273 |
| 3 | PDK2 | 2.14136486 |
| 4 | MUSK | 13.3532128 |
| 5 | BRAF | 1.85958143 |
| 6 | LIMK1 | 1.72915356 |
| 7 | FRK | 1.64092741 |
| 8 | PINK1 | 1.47211842 |
| 9 | NME1 | 1.34160278 |
| 10 | MAP3K12 | 1.28877061 |
| 11 | BCKDK | 1.26020084 |
| 12 | MAP3K13 | 1.23078676 |
| 13 | EIF2AK1 | 1.20252108 |
| 14 | PLK2 | 1.18894097 |
| 15 | STK16 | 1.14344358 |
| 16 | MYLK | 1.06825594 |
| 17 | PLK4 | 1.04900562 |
| 18 | GRK1 | 1.04063339 |
| 19 | NEK1 | 0.99594012 |
| 20 | MAPKAPK3 | 0.97180937 |
| 21 | MST4 | 0.96437882 |
| 22 | DAPK2 | 0.91070863 |
| 23 | ADRBK2 | 0.89857271 |
| 24 | DYRK2 | 0.87763825 |
| 25 | OBSCN | 0.71106878 |
| 26 | MAP3K9 | 0.69179796 |
| 27 | OXSR1 | 0.69064953 |
| 28 | TSSK6 | 0.66133846 |
| 29 | MAP4K2 | 0.64892697 |
| 30 | CDC7 | 0.62977763 |
| 31 | ILK | 0.61335963 |
| 32 | DAPK1 | 0.58949650 |
| 33 | TXK | 0.57369104 |
| 34 | PHKG1 | 0.54078161 |
| 35 | PHKG2 | 0.54078161 |
| 36 | TRPM7 | 0.53758534 |
| 37 | WNK3 | 0.53300149 |
| 38 | AKT2 | 0.52664097 |
| 39 | RPS6KA5 | 0.52358669 |
| 40 | SGK2 | 0.51587703 |
| 41 | BMPR1B | 0.51016936 |
| 42 | DAPK3 | 0.50827494 |
| 43 | PLK3 | 0.48604495 |
| 44 | ADRBK1 | 0.48210218 |
| 45 | MAPKAPK5 | 0.47661167 |
| 46 | PIK3CG | 0.46725410 |
| 47 | VRK2 | 0.46523660 |
| 48 | SGK223 | 0.45069232 |
| 49 | SGK494 | 0.45069232 |
| 50 | STK39 | 0.44896412 |
| 51 | IKBKB | 0.44632390 |
| 52 | EEF2K | 0.44225924 |
| 53 | CSNK1G3 | 0.44066565 |
| 54 | PIM2 | 0.42563503 |
| 55 | CSNK1A1L | 0.42500101 |
| 56 | PIK3CA | 0.41333308 |
| 57 | MAP3K4 | 0.40926530 |
| 58 | CSNK2A2 | 0.40566569 |
| 59 | MAPK13 | 0.40143792 |
| 60 | TEC | 0.39906031 |
| 61 | CDK8 | 0.39118380 |
| 62 | INSRR | 0.39062029 |
| 63 | CSNK2A1 | 0.38600450 |
| 64 | RPS6KA4 | 0.37992825 |
| 65 | CSNK1G1 | 0.37689392 |
| 66 | RPS6KB2 | 0.37435684 |
| 67 | WNK4 | 0.35592613 |
| 68 | GRK7 | 0.34568499 |
| 69 | MAPK12 | 0.31047025 |
| 70 | TESK1 | 0.30919337 |
| 71 | TAOK3 | 0.30806049 |
| 72 | IRAK4 | 0.30421854 |
| 73 | CLK1 | 0.28944028 |
| 74 | TYK2 | 0.28666624 |
| 75 | TAF1 | 0.28155982 |
| 76 | AURKB | 0.27612457 |
| 77 | CSNK1G2 | 0.27181118 |
| 78 | NUAK1 | 0.26833623 |
| 79 | PRKCE | 0.26003543 |
| 80 | TNK2 | 0.25136203 |
| 81 | AURKA | 0.24117335 |
| 82 | TGFBR1 | 0.23788443 |
| 83 | EIF2AK3 | 0.23781431 |
| 84 | RPS6KB1 | 0.23572480 |
| 85 | BRSK1 | 0.23523542 |
| 86 | CSNK1A1 | 0.23375478 |
| 87 | MAP2K7 | 0.23289299 |
| 88 | TIE1 | 0.22954768 |
| 89 | TRIM28 | 0.22670098 |
| 90 | PRKCQ | 0.22590638 |
| 91 | SGK3 | 0.22182763 |
| 92 | PIM1 | 0.21629779 |
| 93 | PRKACA | 0.21509781 |
| 94 | PRKG1 | 0.20769998 |
| 95 | ZAK | 0.19870203 |
| 96 | TGFBR2 | 0.19088651 |
| 97 | BUB1 | 0.17742366 |
| 98 | PAK2 | 0.16881396 |
| 99 | STK4 | 0.16836236 |
| 100 | SGK1 | 0.16805167 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.99054582 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.50323669 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.20962432 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.43369386 |
| 5 | Protein export_Homo sapiens_hsa03060 | 3.31472938 |
| 6 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.99045963 |
| 7 | Proteasome_Homo sapiens_hsa03050 | 2.88859001 |
| 8 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.72568939 |
| 9 | Huntingtons disease_Homo sapiens_hsa05016 | 2.69138243 |
| 10 | Alzheimers disease_Homo sapiens_hsa05010 | 2.68705680 |
| 11 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.39629789 |
| 12 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.22627337 |
| 13 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.18601390 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.97168511 |
| 15 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.90891760 |
| 16 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.81375725 |
| 17 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.79885389 |
| 18 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.75443985 |
| 19 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.70501672 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.66587319 |
| 21 | Homologous recombination_Homo sapiens_hsa03440 | 1.58212225 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.57032213 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.51818106 |
| 24 | Sulfur relay system_Homo sapiens_hsa04122 | 1.37110874 |
| 25 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.31079246 |
| 26 | Peroxisome_Homo sapiens_hsa04146 | 1.29230399 |
| 27 | Purine metabolism_Homo sapiens_hsa00230 | 1.21786807 |
| 28 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.20565789 |
| 29 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.20187736 |
| 30 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.17636854 |
| 31 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.16726045 |
| 32 | Mismatch repair_Homo sapiens_hsa03430 | 1.13553908 |
| 33 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.12104416 |
| 34 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.10833066 |
| 35 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.07380741 |
| 36 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.04665618 |
| 37 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.03163349 |
| 38 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.02221631 |
| 39 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.97916384 |
| 40 | Metabolic pathways_Homo sapiens_hsa01100 | 0.93878766 |
| 41 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.93768293 |
| 42 | Basal transcription factors_Homo sapiens_hsa03022 | 0.89564941 |
| 43 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.83747753 |
| 44 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.83332910 |
| 45 | DNA replication_Homo sapiens_hsa03030 | 0.82569659 |
| 46 | RNA transport_Homo sapiens_hsa03013 | 0.78695342 |
| 47 | Olfactory transduction_Homo sapiens_hsa04740 | 0.78333960 |
| 48 | Spliceosome_Homo sapiens_hsa03040 | 0.76361154 |
| 49 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.76192575 |
| 50 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.74176303 |
| 51 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.73337793 |
| 52 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.72504266 |
| 53 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.71973694 |
| 54 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.71089684 |
| 55 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.69488091 |
| 56 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.67557487 |
| 57 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.64729707 |
| 58 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.64199112 |
| 59 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.62938295 |
| 60 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.59274934 |
| 61 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.57795032 |
| 62 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.57512648 |
| 63 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.57359861 |
| 64 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.54854156 |
| 65 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.53095629 |
| 66 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.50707153 |
| 67 | Retinol metabolism_Homo sapiens_hsa00830 | 0.50397515 |
| 68 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.49773186 |
| 69 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.48189841 |
| 70 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.43926178 |
| 71 | Base excision repair_Homo sapiens_hsa03410 | 0.42241525 |
| 72 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.41460738 |
| 73 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.39717803 |
| 74 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.38704543 |
| 75 | Mineral absorption_Homo sapiens_hsa04978 | 0.37227809 |
| 76 | Melanoma_Homo sapiens_hsa05218 | 0.33432018 |
| 77 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.33056066 |
| 78 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.29655720 |
| 79 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.28286362 |
| 80 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.28102602 |
| 81 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.26509206 |
| 82 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.26309646 |
| 83 | Carbon metabolism_Homo sapiens_hsa01200 | 0.24876925 |
| 84 | Asthma_Homo sapiens_hsa05310 | 0.24867838 |
| 85 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.23863566 |
| 86 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.23513074 |
| 87 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.22727318 |
| 88 | Legionellosis_Homo sapiens_hsa05134 | 0.22182321 |
| 89 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.21151462 |
| 90 | Bladder cancer_Homo sapiens_hsa05219 | 0.20119543 |
| 91 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.19996763 |
| 92 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.18626111 |
| 93 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.16313609 |
| 94 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.15337973 |
| 95 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.13239103 |
| 96 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.11516047 |
| 97 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.10890454 |
| 98 | Malaria_Homo sapiens_hsa05144 | 0.10466965 |
| 99 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.10039610 |
| 100 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.09039405 |

