FTLP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)7.48595623
2energy coupled proton transport, down electrochemical gradient (GO:0015985)7.48595623
3establishment of protein localization to mitochondrial membrane (GO:0090151)6.30747820
4ribosome assembly (GO:0042255)6.06514628
5oxygen transport (GO:0015671)6.04434405
6muscle organ morphogenesis (GO:0048644)6.01091218
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.00502123
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.96448023
9mitochondrial respiratory chain complex I assembly (GO:0032981)5.96448023
10NADH dehydrogenase complex assembly (GO:0010257)5.96448023
11protein complex biogenesis (GO:0070271)5.96358007
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.81081709
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.73112323
14ribosomal small subunit assembly (GO:0000028)5.71114207
15respiratory chain complex IV assembly (GO:0008535)5.63600656
16ribosomal small subunit biogenesis (GO:0042274)5.51149708
17mitochondrial respiratory chain complex assembly (GO:0033108)5.47671542
18chaperone-mediated protein transport (GO:0072321)5.39495287
19response to dietary excess (GO:0002021)5.29084541
20respiratory electron transport chain (GO:0022904)5.00254933
21positive regulation of vesicle fusion (GO:0031340)4.93965918
22electron transport chain (GO:0022900)4.92408163
23gas transport (GO:0015669)4.85580091
24cytochrome complex assembly (GO:0017004)4.84281541
25intracellular protein transmembrane import (GO:0044743)4.71455142
26protein targeting to mitochondrion (GO:0006626)4.53816602
27DNA deamination (GO:0045006)4.51555320
28transcription elongation from RNA polymerase III promoter (GO:0006385)4.47236630
29termination of RNA polymerase III transcription (GO:0006386)4.47236630
30protein neddylation (GO:0045116)4.45145381
31cullin deneddylation (GO:0010388)4.43227139
32proteasome assembly (GO:0043248)4.41843403
33peptidyl-histidine modification (GO:0018202)4.40831377
34establishment of protein localization to mitochondrion (GO:0072655)4.35142545
35viral transcription (GO:0019083)4.30874034
36maturation of 5.8S rRNA (GO:0000460)4.27921066
37ATP biosynthetic process (GO:0006754)4.27632890
38translational termination (GO:0006415)4.27044426
39protein-cofactor linkage (GO:0018065)4.19144615
40maturation of SSU-rRNA (GO:0030490)4.19048547
41pseudouridine synthesis (GO:0001522)4.09532779
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.08226725
43cotranslational protein targeting to membrane (GO:0006613)3.98636982
44protein targeting to ER (GO:0045047)3.98598271
45protein localization to mitochondrion (GO:0070585)3.97609196
46transcription from mitochondrial promoter (GO:0006390)3.94535577
47protein localization to endoplasmic reticulum (GO:0070972)3.87922057
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.86073902
49purine nucleoside triphosphate biosynthetic process (GO:0009145)3.85851606
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.85733759
51rRNA modification (GO:0000154)3.81719094
52autophagic vacuole fusion (GO:0000046)3.79416938
53protein deneddylation (GO:0000338)3.70098809
54protein transmembrane transport (GO:0071806)3.68884346
55translational elongation (GO:0006414)3.65298099
56preassembly of GPI anchor in ER membrane (GO:0016254)3.60986152
57short-chain fatty acid metabolic process (GO:0046459)3.59031570
58translation (GO:0006412)3.58044885
59intracellular protein transmembrane transport (GO:0065002)3.56486638
60hydrogen ion transmembrane transport (GO:1902600)3.44608925
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.43760207
62inner mitochondrial membrane organization (GO:0007007)3.43313572
63positive regulation of prostaglandin secretion (GO:0032308)3.39944723
64cellular component biogenesis (GO:0044085)3.39575140
65ribonucleoside triphosphate biosynthetic process (GO:0009201)3.34230411
66cellular protein complex disassembly (GO:0043624)3.29159885
67cellular respiration (GO:0045333)3.29020847
68translational initiation (GO:0006413)3.27795569
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26893118
70protoporphyrinogen IX biosynthetic process (GO:0006782)3.26161954
71deoxyribose phosphate biosynthetic process (GO:0046385)3.22789820
722-deoxyribonucleotide biosynthetic process (GO:0009265)3.22789820
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22752036
74proton transport (GO:0015992)3.21978432
75positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.20041772
76platelet dense granule organization (GO:0060155)3.18941009
77viral life cycle (GO:0019058)3.18485055
78organelle membrane fusion (GO:0090174)3.17907020
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16782663
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16782663
81mitochondrial transport (GO:0006839)3.16031093
82hydrogen transport (GO:0006818)3.13003548
83deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.12512158
84purine nucleoside monophosphate biosynthetic process (GO:0009127)3.10320531
85purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.10320531
86positive regulation of sodium ion transmembrane transport (GO:1902307)3.10007947
87iron-sulfur cluster assembly (GO:0016226)3.06388856
88metallo-sulfur cluster assembly (GO:0031163)3.06388856
89positive regulation of icosanoid secretion (GO:0032305)3.02570639
90regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99831556
91nucleoside triphosphate biosynthetic process (GO:0009142)2.99271813
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98466339
93myoblast migration (GO:0051451)2.97591726
94GMP metabolic process (GO:0046037)2.96160087
95S-adenosylmethionine metabolic process (GO:0046500)2.94717927
96deoxyribonucleotide catabolic process (GO:0009264)2.93003371
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.90585513
98C-terminal protein lipidation (GO:0006501)2.90513341
99oxidative phosphorylation (GO:0006119)2.89151629
100cellular response to ATP (GO:0071318)2.88954411

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.67112445
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.53601664
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.52505611
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.19130814
5ELF1_17652178_ChIP-ChIP_JURKAT_Human4.11707114
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.79499960
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.70907794
8SRF_21415370_ChIP-Seq_HL-1_Mouse3.24750717
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.12217690
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07018293
11VDR_23849224_ChIP-Seq_CD4+_Human3.02285004
12THAP11_20581084_ChIP-Seq_MESCs_Mouse2.88200580
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.75634043
14ZNF274_21170338_ChIP-Seq_K562_Hela2.70916209
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.70418694
16ZNF263_19887448_ChIP-Seq_K562_Human2.54159569
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52480490
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51410133
19VDR_22108803_ChIP-Seq_LS180_Human2.47789407
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42695480
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42192527
22FOXP3_21729870_ChIP-Seq_TREG_Human2.33434049
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31874484
24DCP1A_22483619_ChIP-Seq_HELA_Human2.30831079
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27546458
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19210147
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.17751790
28GABP_19822575_ChIP-Seq_HepG2_Human2.16785221
29ELK1_19687146_ChIP-ChIP_HELA_Human2.02881970
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97265460
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.94136191
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83472251
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78293814
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72125902
35TTF2_22483619_ChIP-Seq_HELA_Human1.69477806
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.68490320
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59799860
38XRN2_22483619_ChIP-Seq_HELA_Human1.59566782
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54986268
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48195292
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46527386
42MYC_18940864_ChIP-ChIP_HL60_Human1.43447393
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42477910
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40294743
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.37080671
46EWS_26573619_Chip-Seq_HEK293_Human1.35679575
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31605373
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25971470
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25167374
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23933585
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17892383
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16650119
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16450860
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16096006
55SOX2_19829295_ChIP-Seq_ESCs_Human1.13814092
56NANOG_19829295_ChIP-Seq_ESCs_Human1.13814092
57HTT_18923047_ChIP-ChIP_STHdh_Human1.12990391
58TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09495840
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09160742
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.08448156
61AR_20517297_ChIP-Seq_VCAP_Human1.07005005
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04009018
63SALL4_22934838_ChIP-ChIP_CD34+_Human1.04004033
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03523298
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03018301
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02839722
67NANOG_20526341_ChIP-Seq_ESCs_Human1.01996406
68FUS_26573619_Chip-Seq_HEK293_Human1.01915749
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.01672555
70TP53_22573176_ChIP-Seq_HFKS_Human1.01506565
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98927803
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98704574
73BP1_19119308_ChIP-ChIP_Hs578T_Human0.97536237
74MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96385623
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93837604
76FOXH1_21741376_ChIP-Seq_EPCs_Human0.93651762
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90895661
78ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90556434
79IGF1R_20145208_ChIP-Seq_DFB_Human0.88741497
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88487856
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87667213
82GATA3_21878914_ChIP-Seq_MCF-7_Human0.86010952
83P53_21459846_ChIP-Seq_SAOS-2_Human0.85744725
84ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83947220
85TP63_19390658_ChIP-ChIP_HaCaT_Human0.82844995
86NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82596155
87KDM5A_27292631_Chip-Seq_BREAST_Human0.80969712
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80346618
89ERG_20517297_ChIP-Seq_VCAP_Human0.79008903
90TAF2_19829295_ChIP-Seq_ESCs_Human0.78728120
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78216771
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.77477377
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.76557502
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76101513
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73914367
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73914367
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73914367
98E2F4_17652178_ChIP-ChIP_JURKAT_Human0.73429862
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72316867
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.72035969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation7.51625100
2MP0004145_abnormal_muscle_electrophysio6.36571101
3MP0004885_abnormal_endolymph3.58323739
4MP0001188_hyperpigmentation3.36248256
5MP0003806_abnormal_nucleotide_metabolis3.22157626
6MP0000749_muscle_degeneration3.14394823
7MP0003941_abnormal_skin_development2.73117235
8MP0004270_analgesia2.63365400
9MP0006036_abnormal_mitochondrial_physio2.55298862
10MP0003186_abnormal_redox_activity2.54175389
11MP0002837_dystrophic_cardiac_calcinosis2.46052414
12MP0005646_abnormal_pituitary_gland2.42692884
13MP0004147_increased_porphyrin_level2.35445545
14MP0001661_extended_life_span2.33729941
15MP0009046_muscle_twitch2.05575339
16MP0005075_abnormal_melanosome_morpholog2.04315499
17MP0003656_abnormal_erythrocyte_physiolo2.00593047
18MP0003950_abnormal_plasma_membrane1.94980133
19MP0003136_yellow_coat_color1.94186986
20MP0003011_delayed_dark_adaptation1.93650005
21MP0000747_muscle_weakness1.84936722
22MP0003693_abnormal_embryo_hatching1.74981001
23MP0001986_abnormal_taste_sensitivity1.73856307
24MP0002234_abnormal_pharynx_morphology1.69498565
25MP0000750_abnormal_muscle_regeneration1.69070011
26MP0002163_abnormal_gland_morphology1.66812533
27MP0006292_abnormal_olfactory_placode1.62120676
28MP0003786_premature_aging1.51751699
29MP0002138_abnormal_hepatobiliary_system1.44979390
30MP0008058_abnormal_DNA_repair1.41788050
31MP0004381_abnormal_hair_follicle1.41141880
32MP0002277_abnormal_respiratory_mucosa1.35805915
33MP0003195_calcinosis1.33048202
34MP0009379_abnormal_foot_pigmentation1.31840083
35MP0005377_hearing/vestibular/ear_phenot1.26199004
36MP0003878_abnormal_ear_physiology1.26199004
37MP0006035_abnormal_mitochondrial_morpho1.23419339
38MP0003137_abnormal_impulse_conducting1.13922240
39MP0002269_muscular_atrophy1.11307402
40MP0004043_abnormal_pH_regulation1.10674924
41MP0000516_abnormal_urinary_system1.07045846
42MP0005367_renal/urinary_system_phenotyp1.07045846
43MP0005084_abnormal_gallbladder_morpholo1.02421682
44MP0002139_abnormal_hepatobiliary_system1.00047947
45MP0001299_abnormal_eye_distance/1.00037658
46MP0002638_abnormal_pupillary_reflex0.99972854
47MP0000759_abnormal_skeletal_muscle0.99786708
48MP0005220_abnormal_exocrine_pancreas0.99432065
49MP0002876_abnormal_thyroid_physiology0.98899720
50MP0005636_abnormal_mineral_homeostasis0.97894010
51MP0002938_white_spotting0.97331120
52MP0004142_abnormal_muscle_tone0.96701004
53MP0001486_abnormal_startle_reflex0.96191204
54MP0002132_abnormal_respiratory_system0.95251913
55MP0003718_maternal_effect0.95101792
56MP0008875_abnormal_xenobiotic_pharmacok0.93264157
57MP0002933_joint_inflammation0.90337202
58MP0002160_abnormal_reproductive_system0.90110878
59MP0003567_abnormal_fetal_cardiomyocyte0.89466345
60MP0000631_abnormal_neuroendocrine_gland0.88580905
61MP0006072_abnormal_retinal_apoptosis0.86196127
62MP0004215_abnormal_myocardial_fiber0.85845200
63MP0000681_abnormal_thyroid_gland0.84763605
64MP0001764_abnormal_homeostasis0.81937376
65MP0009333_abnormal_splenocyte_physiolog0.80705481
66MP0009765_abnormal_xenobiotic_induced0.80124047
67MP0000569_abnormal_digit_pigmentation0.79852961
68MP0005332_abnormal_amino_acid0.79355142
69MP0002734_abnormal_mechanical_nocicepti0.78192248
70MP0001485_abnormal_pinna_reflex0.76914478
71MP0002736_abnormal_nociception_after0.75683703
72MP0009697_abnormal_copulation0.74592263
73MP0001542_abnormal_bone_strength0.73918685
74MP0005379_endocrine/exocrine_gland_phen0.72693815
75MP0002177_abnormal_outer_ear0.72518269
76MP0001905_abnormal_dopamine_level0.71871404
77MP0003646_muscle_fatigue0.71512436
78MP0003279_aneurysm0.71248880
79MP0001529_abnormal_vocalization0.68516986
80MP0005253_abnormal_eye_physiology0.67313847
81MP0001186_pigmentation_phenotype0.64046311
82MP0000015_abnormal_ear_pigmentation0.63958753
83MP0010030_abnormal_orbit_morphology0.63189945
84MP0001881_abnormal_mammary_gland0.63188541
85MP0001968_abnormal_touch/_nociception0.63065023
86MP0009250_abnormal_appendicular_skeleto0.59349333
87MP0002106_abnormal_muscle_physiology0.59206774
88MP0004233_abnormal_muscle_weight0.58950922
89MP0005058_abnormal_lysosome_morphology0.58780099
90MP0000733_abnormal_muscle_development0.56240883
91MP0005389_reproductive_system_phenotype0.54884514
92MP0001963_abnormal_hearing_physiology0.54563389
93MP0005410_abnormal_fertilization0.54315442
94MP0002095_abnormal_skin_pigmentation0.53737367
95MP0003252_abnormal_bile_duct0.52516576
96MP0000343_altered_response_to0.50156373
97MP0001984_abnormal_olfaction0.49966188
98MP0002102_abnormal_ear_morphology0.48823535
99MP0001191_abnormal_skin_condition0.48751448
100MP0005369_muscle_phenotype0.48664074

Predicted human phenotypes

RankGene SetZ-score
1Type 2 muscle fiber atrophy (HP:0003554)8.87694058
2Muscle fiber atrophy (HP:0100295)7.91346671
3Abnormality of the neuromuscular junction (HP:0003398)6.01828986
4Fatigable weakness (HP:0003473)6.01828986
5Weak cry (HP:0001612)4.86299742
6Acute necrotizing encephalopathy (HP:0006965)4.86162928
7Acute encephalopathy (HP:0006846)4.74710013
8Mitochondrial inheritance (HP:0001427)4.52634912
9Abnormal mitochondria in muscle tissue (HP:0008316)4.43507769
10Increased CSF lactate (HP:0002490)4.40172282
11Abnormality of the heme biosynthetic pathway (HP:0010472)4.35687791
12Hepatocellular necrosis (HP:0001404)4.33435638
13Progressive macrocephaly (HP:0004481)4.33350238
14Hepatic necrosis (HP:0002605)4.28354287
15Easy fatigability (HP:0003388)4.23518509
16Nonprogressive disorder (HP:0003680)3.85577895
17Methylmalonic acidemia (HP:0002912)3.55857342
18Abnormality of placental membranes (HP:0011409)3.53251035
19Amniotic constriction ring (HP:0009775)3.53251035
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39603420
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39603420
22Lipid accumulation in hepatocytes (HP:0006561)3.35323647
23Increased hepatocellular lipid droplets (HP:0006565)3.22391583
24Decreased muscle mass (HP:0003199)3.21854098
25Popliteal pterygium (HP:0009756)3.21536683
26Abnormal hemoglobin (HP:0011902)3.20447088
27Gowers sign (HP:0003391)3.14799561
28Bell-shaped thorax (HP:0001591)3.04449551
29Cerebral edema (HP:0002181)3.02365571
30Renal Fanconi syndrome (HP:0001994)2.99900651
313-Methylglutaconic aciduria (HP:0003535)2.81642972
32Increased intramyocellular lipid droplets (HP:0012240)2.81496492
33Respiratory failure (HP:0002878)2.78031023
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.77225595
35Respiratory difficulties (HP:0002880)2.68850711
36Renal cortical cysts (HP:0000803)2.62260974
37Increased muscle lipid content (HP:0009058)2.60478079
38Fibular aplasia (HP:0002990)2.57557773
39Increased serum lactate (HP:0002151)2.56895785
40Respiratory insufficiency due to muscle weakness (HP:0002747)2.56137574
41Lactic acidosis (HP:0003128)2.54690361
42Methylmalonic aciduria (HP:0012120)2.49449812
43Nausea (HP:0002018)2.48853358
44Absent phalangeal crease (HP:0006109)2.47783976
45CNS demyelination (HP:0007305)2.46922105
46Abnormality of urine glucose concentration (HP:0011016)2.43732940
47Glycosuria (HP:0003076)2.43732940
48Aplasia of the musculature (HP:0100854)2.42701700
49Testicular atrophy (HP:0000029)2.39266560
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36175924
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36157668
52Generalized aminoaciduria (HP:0002909)2.35817856
53Optic disc pallor (HP:0000543)2.32152767
54Exercise intolerance (HP:0003546)2.30241850
55Fetal akinesia sequence (HP:0001989)2.29437518
56Abnormal number of erythroid precursors (HP:0012131)2.27820256
57Exertional dyspnea (HP:0002875)2.27753375
58Abnormality of the renal cortex (HP:0011035)2.26090110
59Microglossia (HP:0000171)2.25550801
60Delayed CNS myelination (HP:0002188)2.21485679
61Pallor (HP:0000980)2.20834897
62Redundant skin (HP:0001582)2.19858861
63Leukodystrophy (HP:0002415)2.18396627
64Abnormality of the vitamin B12 metabolism (HP:0004341)2.06755941
65Alveolar cell carcinoma (HP:0006519)2.04732386
66Decreased central vision (HP:0007663)2.04696079
67Poor suck (HP:0002033)2.03079983
68Abnormal finger flexion creases (HP:0006143)2.01991116
69Absent eyebrow (HP:0002223)2.01524627
70Abnormality of vitamin B metabolism (HP:0004340)2.01031877
71Lethargy (HP:0001254)1.99235504
72Abnormality of cells of the erythroid lineage (HP:0012130)1.98465815
73Delayed gross motor development (HP:0002194)1.97346520
74Cutaneous melanoma (HP:0012056)1.96780572
75Abnormality of fatty-acid metabolism (HP:0004359)1.94743353
76Aplasia/hypoplasia of the uterus (HP:0008684)1.93022245
77Adrenal hypoplasia (HP:0000835)1.92701794
78Wrist flexion contracture (HP:0001239)1.91156784
79Long clavicles (HP:0000890)1.90227334
80Emotional lability (HP:0000712)1.89889570
81Neoplasm of head and neck (HP:0012288)1.88911870
82Esophageal neoplasm (HP:0100751)1.88911870
83Submucous cleft hard palate (HP:0000176)1.88301210
84Hypoplasia of the uterus (HP:0000013)1.87393906
85Hypoplastic heart (HP:0001961)1.87307371
86Malignant hyperthermia (HP:0002047)1.87224450
87Brushfield spots (HP:0001088)1.81804503
88Irregular vertebral endplates (HP:0003301)1.81090808
89Pancreatic cysts (HP:0001737)1.80197551
90Hyperthyroidism (HP:0000836)1.71703735
91Abnormal glycosylation (HP:0012345)1.71160431
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71160431
93Abnormal protein N-linked glycosylation (HP:0012347)1.71160431
94Abnormal protein glycosylation (HP:0012346)1.71160431
95Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69965330
96Dicarboxylic aciduria (HP:0003215)1.69965330
97Type I transferrin isoform profile (HP:0003642)1.66674221
98Neoplasm of the tracheobronchial system (HP:0100552)1.66162335
99Degeneration of anterior horn cells (HP:0002398)1.65631569
100Abnormality of the anterior horn cell (HP:0006802)1.65631569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.54201999
2NME22.86250273
3PDK22.14136486
4MUSK13.3532128
5BRAF1.85958143
6LIMK11.72915356
7FRK1.64092741
8PINK11.47211842
9NME11.34160278
10MAP3K121.28877061
11BCKDK1.26020084
12MAP3K131.23078676
13EIF2AK11.20252108
14PLK21.18894097
15STK161.14344358
16MYLK1.06825594
17PLK41.04900562
18GRK11.04063339
19NEK10.99594012
20MAPKAPK30.97180937
21MST40.96437882
22DAPK20.91070863
23ADRBK20.89857271
24DYRK20.87763825
25OBSCN0.71106878
26MAP3K90.69179796
27OXSR10.69064953
28TSSK60.66133846
29MAP4K20.64892697
30CDC70.62977763
31ILK0.61335963
32DAPK10.58949650
33TXK0.57369104
34PHKG10.54078161
35PHKG20.54078161
36TRPM70.53758534
37WNK30.53300149
38AKT20.52664097
39RPS6KA50.52358669
40SGK20.51587703
41BMPR1B0.51016936
42DAPK30.50827494
43PLK30.48604495
44ADRBK10.48210218
45MAPKAPK50.47661167
46PIK3CG0.46725410
47VRK20.46523660
48SGK2230.45069232
49SGK4940.45069232
50STK390.44896412
51IKBKB0.44632390
52EEF2K0.44225924
53CSNK1G30.44066565
54PIM20.42563503
55CSNK1A1L0.42500101
56PIK3CA0.41333308
57MAP3K40.40926530
58CSNK2A20.40566569
59MAPK130.40143792
60TEC0.39906031
61CDK80.39118380
62INSRR0.39062029
63CSNK2A10.38600450
64RPS6KA40.37992825
65CSNK1G10.37689392
66RPS6KB20.37435684
67WNK40.35592613
68GRK70.34568499
69MAPK120.31047025
70TESK10.30919337
71TAOK30.30806049
72IRAK40.30421854
73CLK10.28944028
74TYK20.28666624
75TAF10.28155982
76AURKB0.27612457
77CSNK1G20.27181118
78NUAK10.26833623
79PRKCE0.26003543
80TNK20.25136203
81AURKA0.24117335
82TGFBR10.23788443
83EIF2AK30.23781431
84RPS6KB10.23572480
85BRSK10.23523542
86CSNK1A10.23375478
87MAP2K70.23289299
88TIE10.22954768
89TRIM280.22670098
90PRKCQ0.22590638
91SGK30.22182763
92PIM10.21629779
93PRKACA0.21509781
94PRKG10.20769998
95ZAK0.19870203
96TGFBR20.19088651
97BUB10.17742366
98PAK20.16881396
99STK40.16836236
100SGK10.16805167

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.99054582
2Ribosome_Homo sapiens_hsa030104.50323669
3Parkinsons disease_Homo sapiens_hsa050124.20962432
4RNA polymerase_Homo sapiens_hsa030203.43369386
5Protein export_Homo sapiens_hsa030603.31472938
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.99045963
7Proteasome_Homo sapiens_hsa030502.88859001
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.72568939
9Huntingtons disease_Homo sapiens_hsa050162.69138243
10Alzheimers disease_Homo sapiens_hsa050102.68705680
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.39629789
12One carbon pool by folate_Homo sapiens_hsa006702.22627337
13Sulfur metabolism_Homo sapiens_hsa009202.18601390
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97168511
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90891760
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.81375725
17Cardiac muscle contraction_Homo sapiens_hsa042601.79885389
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75443985
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.70501672
20Pyrimidine metabolism_Homo sapiens_hsa002401.66587319
21Homologous recombination_Homo sapiens_hsa034401.58212225
22Propanoate metabolism_Homo sapiens_hsa006401.57032213
23RNA degradation_Homo sapiens_hsa030181.51818106
24Sulfur relay system_Homo sapiens_hsa041221.37110874
25Fanconi anemia pathway_Homo sapiens_hsa034601.31079246
26Peroxisome_Homo sapiens_hsa041461.29230399
27Purine metabolism_Homo sapiens_hsa002301.21786807
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20565789
29Folate biosynthesis_Homo sapiens_hsa007901.20187736
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17636854
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16726045
32Mismatch repair_Homo sapiens_hsa034301.13553908
33Glutathione metabolism_Homo sapiens_hsa004801.12104416
34Nucleotide excision repair_Homo sapiens_hsa034201.10833066
35Fatty acid elongation_Homo sapiens_hsa000621.07380741
36Selenocompound metabolism_Homo sapiens_hsa004501.04665618
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03163349
38Collecting duct acid secretion_Homo sapiens_hsa049661.02221631
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.97916384
40Metabolic pathways_Homo sapiens_hsa011000.93878766
41Butanoate metabolism_Homo sapiens_hsa006500.93768293
42Basal transcription factors_Homo sapiens_hsa030220.89564941
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83747753
44Pyruvate metabolism_Homo sapiens_hsa006200.83332910
45DNA replication_Homo sapiens_hsa030300.82569659
46RNA transport_Homo sapiens_hsa030130.78695342
47Olfactory transduction_Homo sapiens_hsa047400.78333960
48Spliceosome_Homo sapiens_hsa030400.76361154
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76192575
50Chemical carcinogenesis_Homo sapiens_hsa052040.74176303
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73337793
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72504266
53Linoleic acid metabolism_Homo sapiens_hsa005910.71973694
54Vitamin B6 metabolism_Homo sapiens_hsa007500.71089684
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69488091
56beta-Alanine metabolism_Homo sapiens_hsa004100.67557487
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.64729707
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64199112
59Fat digestion and absorption_Homo sapiens_hsa049750.62938295
60Arachidonic acid metabolism_Homo sapiens_hsa005900.59274934
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57795032
62Tyrosine metabolism_Homo sapiens_hsa003500.57512648
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57359861
64Nitrogen metabolism_Homo sapiens_hsa009100.54854156
65Vibrio cholerae infection_Homo sapiens_hsa051100.53095629
66Rheumatoid arthritis_Homo sapiens_hsa053230.50707153
67Retinol metabolism_Homo sapiens_hsa008300.50397515
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49773186
69Arginine and proline metabolism_Homo sapiens_hsa003300.48189841
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43926178
71Base excision repair_Homo sapiens_hsa034100.42241525
72Tryptophan metabolism_Homo sapiens_hsa003800.41460738
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.39717803
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38704543
75Mineral absorption_Homo sapiens_hsa049780.37227809
76Melanoma_Homo sapiens_hsa052180.33432018
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33056066
78Phenylalanine metabolism_Homo sapiens_hsa003600.29655720
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.28286362
80Pancreatic secretion_Homo sapiens_hsa049720.28102602
81Caffeine metabolism_Homo sapiens_hsa002320.26509206
82Regulation of autophagy_Homo sapiens_hsa041400.26309646
83Carbon metabolism_Homo sapiens_hsa012000.24876925
84Asthma_Homo sapiens_hsa053100.24867838
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23863566
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23513074
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22727318
88Legionellosis_Homo sapiens_hsa051340.22182321
89p53 signaling pathway_Homo sapiens_hsa041150.21151462
90Bladder cancer_Homo sapiens_hsa052190.20119543
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.19996763
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18626111
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.16313609
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15337973
95Type I diabetes mellitus_Homo sapiens_hsa049400.13239103
96Protein digestion and absorption_Homo sapiens_hsa049740.11516047
97Sphingolipid metabolism_Homo sapiens_hsa006000.10890454
98Malaria_Homo sapiens_hsa051440.10466965
99Synaptic vesicle cycle_Homo sapiens_hsa047210.10039610
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.09039405

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