ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.12995667
2	cytidine metabolic process (GO:0046087)	4.63725119
3	cytidine catabolic process (GO:0006216)	4.63725119
4	cytidine deamination (GO:0009972)	4.63725119
5	water-soluble vitamin biosynthetic process (GO:0042364)	3.96696302
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.94544866
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.90243931
8	platelet dense granule organization (GO:0060155)	3.86906282
9	mannosylation (GO:0097502)	3.63091045
10	proteasome assembly (GO:0043248)	3.56822530
11	negative regulation of telomere maintenance (GO:0032205)	3.48608582
12	protein neddylation (GO:0045116)	3.40830363
13	cellular response to ATP (GO:0071318)	3.29312019
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.25334711
15	ATP synthesis coupled proton transport (GO:0015986)	3.25334711
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.19762121
17	respiratory chain complex IV assembly (GO:0008535)	3.19451911
18	protein complex biogenesis (GO:0070271)	3.16214883
19	fucose catabolic process (GO:0019317)	3.11247406
20	L-fucose metabolic process (GO:0042354)	3.11247406
21	L-fucose catabolic process (GO:0042355)	3.11247406
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.04950295
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.04950295
24	positive regulation of defense response to virus by host (GO:0002230)	3.03390509
25	signal peptide processing (GO:0006465)	3.02717265
26	peptidyl-histidine modification (GO:0018202)	2.98188107
27	preassembly of GPI anchor in ER membrane (GO:0016254)	2.97963457
28	regulation of cellular amino acid metabolic process (GO:0006521)	2.97880337
29	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.97659948
30	cytochrome complex assembly (GO:0017004)	2.96374706
31	mitochondrial respiratory chain complex assembly (GO:0033108)	2.83029076
32	negative regulation of mast cell activation (GO:0033004)	2.80762615
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.80705162
34	regulation of chronic inflammatory response (GO:0002676)	2.76019527
35	positive regulation of prostaglandin secretion (GO:0032308)	2.75909610
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.74594227
37	NADH dehydrogenase complex assembly (GO:0010257)	2.74594227
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.74594227
39	GTP biosynthetic process (GO:0006183)	2.73262271
40	indole-containing compound catabolic process (GO:0042436)	2.72467907
41	indolalkylamine catabolic process (GO:0046218)	2.72467907
42	tryptophan catabolic process (GO:0006569)	2.72467907
43	response to pheromone (GO:0019236)	2.71083764
44	cellular response to interferon-beta (GO:0035458)	2.69818885
45	regulation of regulatory T cell differentiation (GO:0045589)	2.68859036
46	electron transport chain (GO:0022900)	2.66590734
47	adaptation of signaling pathway (GO:0023058)	2.66487192
48	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.65822939
49	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.62844861
50	respiratory electron transport chain (GO:0022904)	2.60875770
51	cellular ketone body metabolic process (GO:0046950)	2.60530772
52	response to interferon-beta (GO:0035456)	2.59698887
53	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.57989059
54	proton transport (GO:0015992)	2.55256244
55	hydrogen ion transmembrane transport (GO:1902600)	2.55096140
56	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.54057660
57	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.53637799
58	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.53637799
59	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.53637799
60	hydrogen transport (GO:0006818)	2.53270305
61	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.51951230
62	ATP hydrolysis coupled proton transport (GO:0015991)	2.51951230
63	regulation of memory T cell differentiation (GO:0043380)	2.51878659
64	ketone body metabolic process (GO:1902224)	2.50475237
65	eosinophil chemotaxis (GO:0048245)	2.50365305
66	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.49795210
67	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.49795210
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.49107000
69	xenobiotic catabolic process (GO:0042178)	2.47487014
70	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.44924055
71	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.44718679
72	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.44479167
73	cellular biogenic amine catabolic process (GO:0042402)	2.43975278
74	amine catabolic process (GO:0009310)	2.43975278
75	GPI anchor metabolic process (GO:0006505)	2.43932072
76	positive regulation of T-helper 1 type immune response (GO:0002827)	2.43769553
77	C-terminal protein lipidation (GO:0006501)	2.43655203
78	chaperone-mediated protein transport (GO:0072321)	2.42669537
79	purine-containing compound salvage (GO:0043101)	2.42229170
80	regulation of inflammatory response to antigenic stimulus (GO:0002861)	2.41763509
81	behavioral response to nicotine (GO:0035095)	2.41067055
82	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.40789251
83	protein deneddylation (GO:0000338)	2.40749392
84	S-adenosylmethionine metabolic process (GO:0046500)	2.40488039
85	piRNA metabolic process (GO:0034587)	2.40437382
86	positive regulation of interleukin-17 production (GO:0032740)	2.40421425
87	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.40064744
88	isotype switching (GO:0045190)	2.40064744
89	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.40064744
90	immunoglobulin mediated immune response (GO:0016064)	2.39917331
91	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.37680380
92	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.37680380
93	tryptophan metabolic process (GO:0006568)	2.37401142
94	GPI anchor biosynthetic process (GO:0006506)	2.36668478
95	cullin deneddylation (GO:0010388)	2.36085916
96	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.34903286
97	glycerophospholipid catabolic process (GO:0046475)	2.34111450
98	negative regulation of acute inflammatory response (GO:0002674)	2.33323509
99	termination of RNA polymerase III transcription (GO:0006386)	2.33302385
100	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.33302385

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.73395706
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.68035809
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.61613017
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.28909347
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.12724403
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.01690001
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.88014862
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.71495831
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.61776224
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.61010116
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58631408
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.57373960
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.48422862
14	VDR_22108803_ChIP-Seq_LS180_Human	2.47135868
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.25840443
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21636560
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.19859219
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.00027187
19	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.96114720
20	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.95364127
21	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.91605608
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.88458945
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.87322035
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78332799
25	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.77830264
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77591556
27	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.77587502
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.76809020
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.73126663
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.71694390
31	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.63425904
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56595018
33	GATA3_26560356_Chip-Seq_TH2_Human	1.55858729
34	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.55184996
35	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.51064298
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40002237
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40002237
38	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.36518184
39	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.35866759
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32833618
41	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.31656182
42	AR_20517297_ChIP-Seq_VCAP_Human	1.30418812
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.30196727
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29944807
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29410975
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26954986
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26954986
48	IGF1R_20145208_ChIP-Seq_DFB_Human	1.26147881
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22712491
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22704183
51	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.22382700
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20689072
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.19629791
54	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.19533104
55	EWS_26573619_Chip-Seq_HEK293_Human	1.17113510
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16071527
57	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.15926683
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15548927
59	MYC_19829295_ChIP-Seq_ESCs_Human	1.14590134
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13797752
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.13657777
62	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12825576
63	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12478929
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10709174
65	P300_19829295_ChIP-Seq_ESCs_Human	1.09813670
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09515129
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08749027
68	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.08718906
69	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.08558543
70	NCOR_22424771_ChIP-Seq_293T_Human	1.08008402
71	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07211967
72	GBX2_23144817_ChIP-Seq_PC3_Human	1.06440634
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05980869
74	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.05707262
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05088817
76	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.04189717
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02895811
78	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02271565
79	CBP_20019798_ChIP-Seq_JUKART_Human	1.02271565
80	ER_23166858_ChIP-Seq_MCF-7_Human	1.02039466
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01224062
82	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99875709
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.99842061
84	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99598976
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99521661
86	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.98726849
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.98332821
88	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97838585
89	GATA3_27048872_Chip-Seq_THYMUS_Human	0.97130106
90	BCAT_22108803_ChIP-Seq_LS180_Human	0.95009263
91	IRF1_19129219_ChIP-ChIP_H3396_Human	0.94892527
92	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.94830048
93	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.94549453
94	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.94430391
95	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.94403887
96	RBPJ_21746931_ChIP-Seq_IB4_Human	0.93965544
97	ERA_21632823_ChIP-Seq_H3396_Human	0.92764737
98	CDX2_22108803_ChIP-Seq_LS180_Human	0.90969584
99	GABP_19822575_ChIP-Seq_HepG2_Human	0.90691404
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.89387153

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	2.76567090
2	MP0003806_abnormal_nucleotide_metabolis	2.74680499
3	MP0001835_abnormal_antigen_presentation	2.61521364
4	MP0008877_abnormal_DNA_methylation	2.56198041
5	MP0003195_calcinosis	2.55209570
6	MP0002102_abnormal_ear_morphology	2.53946114
7	MP0002148_abnormal_hypersensitivity_rea	2.49374536
8	MP0002837_dystrophic_cardiac_calcinosis	2.34368331
9	MP0008875_abnormal_xenobiotic_pharmacok	2.34078448
10	MP0002138_abnormal_hepatobiliary_system	2.28954265
11	MP0003724_increased_susceptibility_to	2.24144928
12	MP0006082_CNS_inflammation	2.21596054
13	MP0005084_abnormal_gallbladder_morpholo	2.16969137
14	MP0002139_abnormal_hepatobiliary_system	2.13637302
15	MP0005360_urolithiasis	2.11911333
16	MP0000685_abnormal_immune_system	2.11630940
17	MP0009785_altered_susceptibility_to	2.02745735
18	MP0002876_abnormal_thyroid_physiology	1.98087318
19	MP0004147_increased_porphyrin_level	1.95032468
20	MP0001790_abnormal_immune_system	1.93077776
21	MP0005387_immune_system_phenotype	1.93077776
22	MP0000372_irregular_coat_pigmentation	1.86227975
23	MP0005167_abnormal_blood-brain_barrier	1.84001215
24	MP0005075_abnormal_melanosome_morpholog	1.78260268
25	MP0008872_abnormal_physiological_respon	1.72620047
26	MP0009764_decreased_sensitivity_to	1.65841248
27	MP0005000_abnormal_immune_tolerance	1.64609639
28	MP0006072_abnormal_retinal_apoptosis	1.61254772
29	MP0005645_abnormal_hypothalamus_physiol	1.61013645
30	MP0003172_abnormal_lysosome_physiology	1.49320621
31	MP0006036_abnormal_mitochondrial_physio	1.45017029
32	MP0009840_abnormal_foam_cell	1.45011915
33	MP0003646_muscle_fatigue	1.43894754
34	MP0003186_abnormal_redox_activity	1.43056299
35	MP0002723_abnormal_immune_serum	1.41559635
36	MP0001800_abnormal_humoral_immune	1.41038116
37	MP0001986_abnormal_taste_sensitivity	1.40150423
38	MP0004885_abnormal_endolymph	1.36456531
39	MP0001968_abnormal_touch/_nociception	1.34529094
40	MP0005332_abnormal_amino_acid	1.30510439
41	MP0002452_abnormal_antigen_presenting	1.30361804
42	MP0002693_abnormal_pancreas_physiology	1.30001837
43	MP0005410_abnormal_fertilization	1.29163627
44	MP0003011_delayed_dark_adaptation	1.28305216
45	MP0005379_endocrine/exocrine_gland_phen	1.28025735
46	MP0003787_abnormal_imprinting	1.25709688
47	MP0001756_abnormal_urination	1.25695587
48	MP0001845_abnormal_inflammatory_respons	1.23775252
49	MP0005025_abnormal_response_to	1.23338862
50	MP0010386_abnormal_urinary_bladder	1.23001603
51	MP0002420_abnormal_adaptive_immunity	1.21472591
52	MP0005058_abnormal_lysosome_morphology	1.21287571
53	MP0001905_abnormal_dopamine_level	1.20984411
54	MP0002163_abnormal_gland_morphology	1.20045743
55	MP0002254_reproductive_system_inflammat	1.19966589
56	MP0001819_abnormal_immune_cell	1.19785236
57	MP0008469_abnormal_protein_level	1.18635847
58	MP0002166_altered_tumor_susceptibility	1.15346403
59	MP0004142_abnormal_muscle_tone	1.13491329
60	MP0005365_abnormal_bile_salt	1.12967311
61	MP0005551_abnormal_eye_electrophysiolog	1.12519349
62	MP0001919_abnormal_reproductive_system	1.11519814
63	MP0002419_abnormal_innate_immunity	1.09936840
64	MP0005253_abnormal_eye_physiology	1.09183097
65	MP0005636_abnormal_mineral_homeostasis	1.09137464
66	MP0010329_abnormal_lipoprotein_level	1.09010922
67	MP0004019_abnormal_vitamin_homeostasis	1.08843417
68	MP0009333_abnormal_splenocyte_physiolog	1.07852471
69	MP0003786_premature_aging	1.07578811
70	MP0003866_abnormal_defecation	1.07505746
71	MP0005464_abnormal_platelet_physiology	1.04164157
72	MP0001984_abnormal_olfaction	1.03708052
73	MP0006035_abnormal_mitochondrial_morpho	1.02810624
74	MP0002736_abnormal_nociception_after	1.02403941
75	MP0004043_abnormal_pH_regulation	1.02267087
76	MP0002277_abnormal_respiratory_mucosa	1.02110993
77	MP0002006_tumorigenesis	1.00327748
78	MP0005174_abnormal_tail_pigmentation	0.99287228
79	MP0003252_abnormal_bile_duct	0.99207200
80	MP0000015_abnormal_ear_pigmentation	0.98465122
81	MP0002638_abnormal_pupillary_reflex	0.95772905
82	MP0000569_abnormal_digit_pigmentation	0.95095927
83	MP0001764_abnormal_homeostasis	0.93240207
84	MP0005389_reproductive_system_phenotype	0.89730132
85	MP0009643_abnormal_urine_homeostasis	0.88659175
86	MP0005408_hypopigmentation	0.88405809
87	MP0005646_abnormal_pituitary_gland	0.87442674
88	MP0003075_altered_response_to	0.86938146
89	MP0005085_abnormal_gallbladder_physiolo	0.86477314
90	MP0010155_abnormal_intestine_physiology	0.86459528
91	MP0005319_abnormal_enzyme/_coenzyme	0.85243986
92	MP0003718_maternal_effect	0.85033068
93	MP0003436_decreased_susceptibility_to	0.85025180
94	MP0004145_abnormal_muscle_electrophysio	0.82732085
95	MP0002095_abnormal_skin_pigmentation	0.82467512
96	MP0000230_abnormal_systemic_arterial	0.81212317
97	MP0000689_abnormal_spleen_morphology	0.80832746
98	MP0001501_abnormal_sleep_pattern	0.76869913
99	MP0002909_abnormal_adrenal_gland	0.75851239
100	MP0002405_respiratory_system_inflammati	0.75639712

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	4.48215687
2	Hepatic necrosis (HP:0002605)	3.50045290
3	Acute necrotizing encephalopathy (HP:0006965)	3.48160337
4	Increased CSF lactate (HP:0002490)	3.39873671
5	Hepatocellular necrosis (HP:0001404)	3.34339531
6	Mitochondrial inheritance (HP:0001427)	3.30107765
7	Acute encephalopathy (HP:0006846)	3.17343135
8	Progressive macrocephaly (HP:0004481)	3.14260452
9	Hypoproteinemia (HP:0003075)	3.13900333
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.00883675
11	Abnormality of the renal cortex (HP:0011035)	2.96781542
12	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.81605030
13	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.81605030
14	Type I transferrin isoform profile (HP:0003642)	2.78477271
15	IgG deficiency (HP:0004315)	2.74291158
16	Methylmalonic aciduria (HP:0012120)	2.73742117
17	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.70171919
18	Methylmalonic acidemia (HP:0002912)	2.70122933
19	Generalized aminoaciduria (HP:0002909)	2.69231305
20	Hypomagnesemia (HP:0002917)	2.69052954
21	Abnormality of glycolipid metabolism (HP:0010969)	2.65983369
22	Abnormality of liposaccharide metabolism (HP:0010968)	2.65983369
23	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.65983369
24	Congenital stationary night blindness (HP:0007642)	2.65140755
25	Tongue fasciculations (HP:0001308)	2.64613339
26	Vacuolated lymphocytes (HP:0001922)	2.63223017
27	Pancreatic cysts (HP:0001737)	2.61481952
28	Abnormal drinking behavior (HP:0030082)	2.56881878
29	Polydipsia (HP:0001959)	2.56881878
30	3-Methylglutaconic aciduria (HP:0003535)	2.53542633
31	Increased serum lactate (HP:0002151)	2.50048266
32	Abolished electroretinogram (ERG) (HP:0000550)	2.47041637
33	Hypothermia (HP:0002045)	2.43338661
34	Nephronophthisis (HP:0000090)	2.43122867
35	Renal cortical cysts (HP:0000803)	2.43044793
36	Abnormal glycosylation (HP:0012345)	2.39647073
37	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.39647073
38	Abnormal protein N-linked glycosylation (HP:0012347)	2.39647073
39	Abnormal protein glycosylation (HP:0012346)	2.39647073
40	Polyuria (HP:0000103)	2.38324425
41	Increased IgM level (HP:0003496)	2.36508342
42	Lactic acidosis (HP:0003128)	2.35957424
43	Lipid accumulation in hepatocytes (HP:0006561)	2.33414989
44	Hypoglycemic coma (HP:0001325)	2.31705678
45	Increased hepatocellular lipid droplets (HP:0006565)	2.31492503
46	Molar tooth sign on MRI (HP:0002419)	2.30220885
47	Abnormality of midbrain morphology (HP:0002418)	2.30220885
48	Abnormality of magnesium homeostasis (HP:0004921)	2.27649422
49	Abnormality of the renal medulla (HP:0100957)	2.22806116
50	Large for gestational age (HP:0001520)	2.20279842
51	Optic disc pallor (HP:0000543)	2.19826610
52	Progressive inability to walk (HP:0002505)	2.19041040
53	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.19003529
54	Lethargy (HP:0001254)	2.17713873
55	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.17637897
56	Dicarboxylic aciduria (HP:0003215)	2.17637897
57	Renal Fanconi syndrome (HP:0001994)	2.17562437
58	Respiratory failure (HP:0002878)	2.16781728
59	Muscle fibrillation (HP:0010546)	2.15181848
60	Tubular atrophy (HP:0000092)	2.10768849
61	Abnormality of T cell number (HP:0011839)	2.09835040
62	Cerebral edema (HP:0002181)	2.09511466
63	Aplasia/hypoplasia of the uterus (HP:0008684)	2.09380912
64	Chronic diarrhea (HP:0002028)	2.08518251
65	Abnormality of T cells (HP:0002843)	2.07584075
66	CNS demyelination (HP:0007305)	2.07535325
67	Elevated erythrocyte sedimentation rate (HP:0003565)	2.06542973
68	Glycosuria (HP:0003076)	2.06391742
69	Abnormality of urine glucose concentration (HP:0011016)	2.06391742
70	Ketoacidosis (HP:0001993)	2.06123176
71	Abnormality of the prostate (HP:0008775)	2.02264686
72	T lymphocytopenia (HP:0005403)	2.01432736
73	Reduced antithrombin III activity (HP:0001976)	2.00277290
74	Pancreatic fibrosis (HP:0100732)	1.98708363
75	Mutism (HP:0002300)	1.98376746
76	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.97577385
77	Abnormality of alanine metabolism (HP:0010916)	1.97577385
78	Hyperalaninemia (HP:0003348)	1.97577385
79	Progressive microcephaly (HP:0000253)	1.97521745
80	Abnormality of the pons (HP:0007361)	1.96164271
81	Abnormal urine output (HP:0012590)	1.94973593
82	Abnormality of T cell physiology (HP:0011840)	1.93217517
83	Type II lissencephaly (HP:0007260)	1.92340954
84	Congenital, generalized hypertrichosis (HP:0004540)	1.88650292
85	Nausea (HP:0002018)	1.88504776
86	Attenuation of retinal blood vessels (HP:0007843)	1.88230418
87	Constricted visual fields (HP:0001133)	1.88220490
88	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.87950682
89	Abnormality of vitamin B metabolism (HP:0004340)	1.87863728
90	Exertional dyspnea (HP:0002875)	1.85948658
91	Facial diplegia (HP:0001349)	1.85295134
92	Abnormality of transition element cation homeostasis (HP:0011030)	1.84449288
93	Severe muscular hypotonia (HP:0006829)	1.84220760
94	Hyperglycemia (HP:0003074)	1.83302118
95	Increased intramyocellular lipid droplets (HP:0012240)	1.81175772
96	Ketosis (HP:0001946)	1.80719577
97	Inability to walk (HP:0002540)	1.79599839
98	Hypoalbuminemia (HP:0003073)	1.79599596
99	Abnormal albumin level (HP:0012116)	1.79599596
100	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.78521498

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.47461769
2	MST4	2.98808521
3	ZAK	2.93607675
4	ADRBK2	2.76964093
5	TLK1	2.68394598
6	TAOK3	2.56973348
7	BMPR1B	2.50047251
8	GRK1	2.49867301
9	MAP4K2	2.44577979
10	NUAK1	2.33138439
11	TXK	2.18930794
12	WNK4	2.16642716
13	VRK2	2.03646971
14	EIF2AK3	1.86026122
15	TRIM28	1.84407617
16	PINK1	1.84048018
17	TIE1	1.83312292
18	EIF2AK1	1.61294355
19	IKBKB	1.59904651
20	BCKDK	1.58347426
21	INSRR	1.56830197
22	PLK2	1.55118728
23	MAP3K12	1.49700311
24	DAPK2	1.45390311
25	MAP2K6	1.44173140
26	MAPKAPK3	1.42750100
27	ACVR1B	1.40579035
28	FES	1.37306990
29	VRK1	1.33378619
30	TEC	1.33183902
31	STK39	1.30767995
32	OXSR1	1.23124320
33	ITK	1.20966182
34	WNK3	1.19923124
35	CAMKK2	1.17219732
36	MAP4K1	1.15817295
37	PHKG2	1.14761687
38	PHKG1	1.14761687
39	FER	1.11877676
40	KIT	1.10956753
41	LIMK1	1.05275630
42	CSNK1G3	1.04774611
43	MYLK	0.99610012
44	SYK	0.96303317
45	BMPR2	0.93477007
46	CSNK1G1	0.92491373
47	GRK7	0.90987262
48	PLK3	0.90156535
49	NME1	0.89592670
50	IKBKE	0.89328331
51	DAPK1	0.88614211
52	MAPKAPK5	0.87683554
53	TGFBR1	0.86947458
54	PRKCE	0.82870937
55	TSSK6	0.82697509
56	PLK4	0.80965370
57	KDR	0.80879095
58	PRKCQ	0.80862125
59	MAP3K14	0.79495260
60	PDK2	0.76817158
61	CHUK	0.75636160
62	CSNK1G2	0.75497467
63	CSNK1A1L	0.74741004
64	PTK2B	0.72043310
65	PRKCG	0.70601556
66	GRK5	0.69745661
67	CDK8	0.68452071
68	LYN	0.66395552
69	ADRBK1	0.64575414
70	JAK3	0.64347647
71	PRKCI	0.62647390
72	RPS6KA5	0.61529429
73	SRPK1	0.57470522
74	SIK3	0.56273913
75	LCK	0.52248888
76	PAK3	0.52032172
77	STK16	0.51429275
78	DYRK2	0.51342217
79	CSF1R	0.48570968
80	TNK2	0.46019629
81	GRK6	0.45728211
82	IGF1R	0.43080425
83	PRKCD	0.41504500
84	TBK1	0.41201451
85	MARK3	0.39319870
86	PIK3CA	0.39237640
87	ERBB3	0.39214199
88	MAP2K2	0.37839993
89	EIF2AK2	0.37684225
90	PRKCA	0.36107593
91	ZAP70	0.35734904
92	PIK3CG	0.34032171
93	TRPM7	0.32691962
94	TGFBR2	0.31473437
95	RIPK4	0.31437282
96	PRKAA2	0.31340158
97	PRKACA	0.31319445
98	MATK	0.31260282
99	CSNK1A1	0.31152947
100	FLT3	0.29993490

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.35468114
2	Proteasome_Homo sapiens_hsa03050	3.20040831
3	Allograft rejection_Homo sapiens_hsa05330	2.97963057
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.96028743
5	Type I diabetes mellitus_Homo sapiens_hsa04940	2.86184051
6	Protein export_Homo sapiens_hsa03060	2.80894548
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.78044966
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.76355831
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.58471909
10	Rheumatoid arthritis_Homo sapiens_hsa05323	2.17502338
11	Sulfur metabolism_Homo sapiens_hsa00920	2.09265895
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.06774573
13	Parkinsons disease_Homo sapiens_hsa05012	2.05153384
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93619734
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.67170816
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.65232362
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.63756281
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.60987724
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.60330888
20	RNA polymerase_Homo sapiens_hsa03020	1.50642586
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.47976670
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.46998874
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43259447
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.38419202
25	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.33639836
26	Propanoate metabolism_Homo sapiens_hsa00640	1.29655949
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.28111710
28	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.24511016
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.20362292
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19456138
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.19297410
32	Caffeine metabolism_Homo sapiens_hsa00232	1.18199737
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.17658831
34	Phototransduction_Homo sapiens_hsa04744	1.17393267
35	Alzheimers disease_Homo sapiens_hsa05010	1.16349980
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15591102
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11734075
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.11715236
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.09629937
40	Butanoate metabolism_Homo sapiens_hsa00650	1.04957804
41	Huntingtons disease_Homo sapiens_hsa05016	1.04928375
42	Lysosome_Homo sapiens_hsa04142	1.00166607
43	Selenocompound metabolism_Homo sapiens_hsa00450	0.99292497
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.98409848
45	Peroxisome_Homo sapiens_hsa04146	0.97095096
46	Fatty acid elongation_Homo sapiens_hsa00062	0.96418550
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.95921286
48	Regulation of autophagy_Homo sapiens_hsa04140	0.86808078
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86604467
50	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.84298683
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82332409
52	RNA degradation_Homo sapiens_hsa03018	0.79602870
53	Mineral absorption_Homo sapiens_hsa04978	0.78391299
54	Homologous recombination_Homo sapiens_hsa03440	0.76603728
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.76081383
56	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.75573920
57	Glutathione metabolism_Homo sapiens_hsa00480	0.75428854
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75152515
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71650290
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.71373134
61	Viral myocarditis_Homo sapiens_hsa05416	0.70490495
62	Legionellosis_Homo sapiens_hsa05134	0.70440488
63	Basal transcription factors_Homo sapiens_hsa03022	0.70208680
64	One carbon pool by folate_Homo sapiens_hsa00670	0.68014536
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67628277
66	Purine metabolism_Homo sapiens_hsa00230	0.65798705
67	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.65570498
68	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.65506257
69	Leishmaniasis_Homo sapiens_hsa05140	0.65239247
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.63815812
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62677784
72	Folate biosynthesis_Homo sapiens_hsa00790	0.61574697
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.60467634
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.59767007
75	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.59001019
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58726394
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57750279
78	Metabolic pathways_Homo sapiens_hsa01100	0.57216879
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.55467403
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54339113
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.53553586
82	Phagosome_Homo sapiens_hsa04145	0.52644981
83	Other glycan degradation_Homo sapiens_hsa00511	0.51750608
84	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.50760853
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49252754
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48019171
87	Fatty acid degradation_Homo sapiens_hsa00071	0.47648460
88	Vibrio cholerae infection_Homo sapiens_hsa05110	0.46979127
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.44381780
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.43468149
91	Fanconi anemia pathway_Homo sapiens_hsa03460	0.43131415
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41226236
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41185932
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40700088
95	Herpes simplex infection_Homo sapiens_hsa05168	0.40623015
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38272095
97	Tuberculosis_Homo sapiens_hsa05152	0.38153196
98	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.37474511
99	Retinol metabolism_Homo sapiens_hsa00830	0.36096656
100	Pyruvate metabolism_Homo sapiens_hsa00620	0.35739956

FTLP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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