FTLP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.99383985
2cytidine deamination (GO:0009972)6.32430037
3cytidine metabolic process (GO:0046087)6.32430037
4cytidine catabolic process (GO:0006216)6.32430037
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.38004162
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.37334301
7platelet dense granule organization (GO:0060155)3.78361795
8eosinophil chemotaxis (GO:0048245)3.63721504
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62885832
10regulation of activation of Janus kinase activity (GO:0010533)3.59767123
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.47957028
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46750315
13protein neddylation (GO:0045116)3.42039306
14ATP synthesis coupled proton transport (GO:0015986)3.41027450
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.41027450
16regulation of chronic inflammatory response (GO:0002676)3.34075094
17protein complex biogenesis (GO:0070271)3.33725524
18eosinophil migration (GO:0072677)3.29026915
19respiratory chain complex IV assembly (GO:0008535)3.26220968
20respiratory electron transport chain (GO:0022904)3.23370687
21electron transport chain (GO:0022900)3.22570099
22cytochrome complex assembly (GO:0017004)3.22385039
23positive regulation of defense response to virus by host (GO:0002230)3.20030069
24water-soluble vitamin biosynthetic process (GO:0042364)3.18875915
25pyrimidine nucleoside catabolic process (GO:0046135)3.18707960
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12944517
27cullin deneddylation (GO:0010388)3.11797635
28protein deneddylation (GO:0000338)3.11287203
29regulation of cellular amino acid metabolic process (GO:0006521)3.08531911
30response to interferon-beta (GO:0035456)3.07313864
31regulation of B cell receptor signaling pathway (GO:0050855)3.05645075
32positive regulation of T cell mediated cytotoxicity (GO:0001916)3.03537118
33actin nucleation (GO:0045010)2.98543057
34proteasome assembly (GO:0043248)2.95085329
35positive regulation of prostaglandin secretion (GO:0032308)2.93048253
36mitochondrial respiratory chain complex assembly (GO:0033108)2.92979398
37positive regulation of calcium-mediated signaling (GO:0050850)2.92806799
38mannosylation (GO:0097502)2.88510808
39positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.86194547
40regulation of T cell receptor signaling pathway (GO:0050856)2.85620536
41positive regulation of interleukin-8 secretion (GO:2000484)2.85427968
42negative regulation of T cell apoptotic process (GO:0070233)2.80273054
43negative regulation by host of viral transcription (GO:0043922)2.79622978
44metallo-sulfur cluster assembly (GO:0031163)2.79580042
45iron-sulfur cluster assembly (GO:0016226)2.79580042
46regulation of regulatory T cell differentiation (GO:0045589)2.77273096
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73675370
48indole-containing compound catabolic process (GO:0042436)2.72884020
49indolalkylamine catabolic process (GO:0046218)2.72884020
50tryptophan catabolic process (GO:0006569)2.72884020
51positive thymic T cell selection (GO:0045059)2.72055932
52negative regulation of viral genome replication (GO:0045071)2.70578621
53mitochondrial respiratory chain complex I assembly (GO:0032981)2.70088192
54NADH dehydrogenase complex assembly (GO:0010257)2.70088192
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70088192
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.67765541
57regulation of interleukin-8 secretion (GO:2000482)2.67492383
58response to pheromone (GO:0019236)2.65698605
59DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65483662
60regulation of T cell mediated cytotoxicity (GO:0001914)2.65091243
61indolalkylamine metabolic process (GO:0006586)2.64053286
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.61842671
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61842671
64positive regulation of natural killer cell mediated immunity (GO:0002717)2.61050616
65positive regulation of lymphocyte migration (GO:2000403)2.59986975
66macrophage chemotaxis (GO:0048246)2.59682895
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.59585147
68establishment of protein localization to mitochondrial membrane (GO:0090151)2.59344385
69hydrogen ion transmembrane transport (GO:1902600)2.58069340
70positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.58012716
71S-adenosylmethionine metabolic process (GO:0046500)2.57993939
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.56612643
73positive regulation of monocyte chemotaxis (GO:0090026)2.56184379
74proton transport (GO:0015992)2.55645334
75positive T cell selection (GO:0043368)2.54392508
76regulation of leukocyte mediated cytotoxicity (GO:0001910)2.53849533
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53122262
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53122262
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53122262
80negative regulation of mast cell activation (GO:0033004)2.52640401
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51787185
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.51733619
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.51733619
84hydrogen transport (GO:0006818)2.51637642
85regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.49640096
86adenosine metabolic process (GO:0046085)2.49508913
87positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.48579248
88positive regulation of cell killing (GO:0031343)2.47495723
89sequestering of actin monomers (GO:0042989)2.45469525
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.44980061
91tryptophan metabolic process (GO:0006568)2.44456195
92regulation of calcium-mediated signaling (GO:0050848)2.44286902
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43858735
94T cell migration (GO:0072678)2.43600060
95immunoglobulin mediated immune response (GO:0016064)2.43521370
96regulation of lymphocyte chemotaxis (GO:1901623)2.40782601
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.38916358
98positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.36852692
99GPI anchor metabolic process (GO:0006505)2.36744927
100regulation of T cell chemotaxis (GO:0010819)2.35694641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.42682927
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.62827458
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.29969817
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20007737
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16566840
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.14867907
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.14831448
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12372943
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82448955
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.53956571
11ZNF274_21170338_ChIP-Seq_K562_Hela2.50733797
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.47589109
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46157070
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35442005
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35267682
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29211769
17VDR_22108803_ChIP-Seq_LS180_Human2.22836174
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.07537080
19VDR_23849224_ChIP-Seq_CD4+_Human2.07512226
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02260392
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.97586773
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.90151979
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.73677647
24TP53_22573176_ChIP-Seq_HFKS_Human1.62269664
25IGF1R_20145208_ChIP-Seq_DFB_Human1.60943985
26GATA3_26560356_Chip-Seq_TH2_Human1.59972063
27FOXP3_21729870_ChIP-Seq_TREG_Human1.57944674
28AR_20517297_ChIP-Seq_VCAP_Human1.53147883
29FOXA1_25329375_ChIP-Seq_VCAP_Human1.49091212
30FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49091212
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48520291
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48331969
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48035418
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47971541
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46632250
36ELK1_19687146_ChIP-ChIP_HELA_Human1.45557710
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.44264334
38MYB_26560356_Chip-Seq_TH2_Human1.43117481
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42554513
40HTT_18923047_ChIP-ChIP_STHdh_Human1.42206164
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35901153
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34165043
43NANOG_19829295_ChIP-Seq_ESCs_Human1.33810334
44SOX2_19829295_ChIP-Seq_ESCs_Human1.33810334
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31036942
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30806831
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27953237
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.26372880
49PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26264957
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25883251
51TAF2_19829295_ChIP-Seq_ESCs_Human1.22534123
52GATA3_27048872_Chip-Seq_THYMUS_Human1.22387085
53NANOG_20526341_ChIP-Seq_ESCs_Human1.21703011
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21312844
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20736482
56NCOR_22424771_ChIP-Seq_293T_Human1.20197789
57MYC_18940864_ChIP-ChIP_HL60_Human1.19084406
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17935569
59TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17445866
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17139300
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16986037
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15890161
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.13078942
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12730193
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12554226
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12282148
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11612514
68ER_23166858_ChIP-Seq_MCF-7_Human1.10593416
69P300_19829295_ChIP-Seq_ESCs_Human1.10380969
70GBX2_23144817_ChIP-Seq_PC3_Human1.10020316
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09239094
72MYC_19829295_ChIP-Seq_ESCs_Human1.08779568
73EWS_26573619_Chip-Seq_HEK293_Human1.08368139
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07917089
75ERG_20517297_ChIP-Seq_VCAP_Human1.07723990
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05021801
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04961366
78RUNX_20019798_ChIP-Seq_JUKART_Human1.04313963
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04074066
80FOXH1_21741376_ChIP-Seq_EPCs_Human1.03825859
81GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.03034734
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02478275
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01278577
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00480413
85CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98980095
86BCAT_22108803_ChIP-Seq_LS180_Human0.98821919
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98663281
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98466415
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.97564335
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97395274
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97173365
92RBPJ_21746931_ChIP-Seq_IB4_Human0.96524565
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95615707
94CBP_20019798_ChIP-Seq_JUKART_Human0.95615707
95STAT1_20625510_ChIP-Seq_HELA_Human0.95558899
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.94872717
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94497673
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93509835
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93331352
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92000903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.20635004
2MP0009785_altered_susceptibility_to2.91511551
3MP0001835_abnormal_antigen_presentation2.75183832
4MP0003195_calcinosis2.51061317
5MP0002148_abnormal_hypersensitivity_rea2.42971293
6MP0008875_abnormal_xenobiotic_pharmacok2.25361883
7MP0003806_abnormal_nucleotide_metabolis2.16813531
8MP0006082_CNS_inflammation2.15191363
9MP0004147_increased_porphyrin_level2.08016400
10MP0006072_abnormal_retinal_apoptosis2.06540348
11MP0002876_abnormal_thyroid_physiology2.05068552
12MP0005000_abnormal_immune_tolerance2.03865617
13MP0005645_abnormal_hypothalamus_physiol2.03724651
14MP0000372_irregular_coat_pigmentation1.96326297
15MP0002837_dystrophic_cardiac_calcinosis1.88607049
16MP0001800_abnormal_humoral_immune1.83655967
17MP0009333_abnormal_splenocyte_physiolog1.83238748
18MP0008872_abnormal_physiological_respon1.83145782
19MP0005646_abnormal_pituitary_gland1.83139672
20MP0001790_abnormal_immune_system1.75463167
21MP0005387_immune_system_phenotype1.75463167
22MP0002102_abnormal_ear_morphology1.74434509
23MP0002723_abnormal_immune_serum1.73872372
24MP0005025_abnormal_response_to1.73549425
25MP0000685_abnormal_immune_system1.70158643
26MP0002138_abnormal_hepatobiliary_system1.67853284
27MP0002420_abnormal_adaptive_immunity1.60438326
28MP0002163_abnormal_gland_morphology1.59729906
29MP0003724_increased_susceptibility_to1.58763405
30MP0001819_abnormal_immune_cell1.57603806
31MP0002452_abnormal_antigen_presenting1.55132867
32MP0005379_endocrine/exocrine_gland_phen1.52320571
33MP0002139_abnormal_hepatobiliary_system1.50156971
34MP0005084_abnormal_gallbladder_morpholo1.49818472
35MP0006036_abnormal_mitochondrial_physio1.48750564
36MP0005551_abnormal_eye_electrophysiolog1.48114894
37MP0005360_urolithiasis1.45101662
38MP0003011_delayed_dark_adaptation1.43459320
39MP0005464_abnormal_platelet_physiology1.43409511
40MP0005075_abnormal_melanosome_morpholog1.43267433
41MP0009764_decreased_sensitivity_to1.42175491
42MP0010386_abnormal_urinary_bladder1.39353525
43MP0005410_abnormal_fertilization1.33572614
44MP0003646_muscle_fatigue1.33063632
45MP0001845_abnormal_inflammatory_respons1.30744642
46MP0005636_abnormal_mineral_homeostasis1.30327229
47MP0008877_abnormal_DNA_methylation1.29947838
48MP0002166_altered_tumor_susceptibility1.26202547
49MP0002419_abnormal_innate_immunity1.24541834
50MP0001764_abnormal_homeostasis1.24539736
51MP0003866_abnormal_defecation1.24315263
52MP0003763_abnormal_thymus_physiology1.23255890
53MP0003186_abnormal_redox_activity1.22749194
54MP0002693_abnormal_pancreas_physiology1.22715180
55MP0001905_abnormal_dopamine_level1.22687930
56MP0001873_stomach_inflammation1.21721408
57MP0001968_abnormal_touch/_nociception1.20928736
58MP0005253_abnormal_eye_physiology1.20761980
59MP0008469_abnormal_protein_level1.20736611
60MP0005332_abnormal_amino_acid1.19950980
61MP0002277_abnormal_respiratory_mucosa1.19273733
62MP0000716_abnormal_immune_system1.15394446
63MP0001986_abnormal_taste_sensitivity1.14618673
64MP0010155_abnormal_intestine_physiology1.14264421
65MP0002006_tumorigenesis1.13242139
66MP0003786_premature_aging1.13049769
67MP0005389_reproductive_system_phenotype1.12886038
68MP0001501_abnormal_sleep_pattern1.11940007
69MP0003436_decreased_susceptibility_to1.07214325
70MP0001919_abnormal_reproductive_system1.03684698
71MP0002398_abnormal_bone_marrow1.03457015
72MP0000689_abnormal_spleen_morphology1.02857154
73MP0002736_abnormal_nociception_after1.02550060
74MP0003075_altered_response_to0.98996139
75MP0001984_abnormal_olfaction0.98227535
76MP0002405_respiratory_system_inflammati0.96634187
77MP0005174_abnormal_tail_pigmentation0.94793083
78MP0009643_abnormal_urine_homeostasis0.91302783
79MP0004885_abnormal_endolymph0.90901312
80MP0002429_abnormal_blood_cell0.90139003
81MP0001765_abnormal_ion_homeostasis0.88867484
82MP0005085_abnormal_gallbladder_physiolo0.88786169
83MP0009763_increased_sensitivity_to0.86355662
84MP0001756_abnormal_urination0.85967672
85MP0002095_abnormal_skin_pigmentation0.85900550
86MP0005365_abnormal_bile_salt0.84925244
87MP0004145_abnormal_muscle_electrophysio0.84438419
88MP0006276_abnormal_autonomic_nervous0.84310406
89MP0002722_abnormal_immune_system0.84079918
90MP0000230_abnormal_systemic_arterial0.81288040
91MP0009046_muscle_twitch0.80567257
92MP0003252_abnormal_bile_duct0.79644997
93MP0002638_abnormal_pupillary_reflex0.79623389
94MP0010329_abnormal_lipoprotein_level0.77744937
95MP0008995_early_reproductive_senescence0.77716201
96MP0001533_abnormal_skeleton_physiology0.76020769
97MP0001542_abnormal_bone_strength0.75939095
98MP0001853_heart_inflammation0.75743694
99MP0006054_spinal_hemorrhage0.75664879
100MP0002132_abnormal_respiratory_system0.75266991

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)3.95461913
2Acute necrotizing encephalopathy (HP:0006965)3.90846041
3Abnormal mitochondria in muscle tissue (HP:0008316)3.54716368
4Increased CSF lactate (HP:0002490)3.51835024
5Progressive macrocephaly (HP:0004481)3.44566200
6Hepatocellular necrosis (HP:0001404)3.42868914
7Hepatic necrosis (HP:0002605)3.34074098
83-Methylglutaconic aciduria (HP:0003535)3.33984223
9Acute encephalopathy (HP:0006846)3.31812988
10Stomatitis (HP:0010280)3.24747614
11Congenital stationary night blindness (HP:0007642)3.24579166
12Increased hepatocellular lipid droplets (HP:0006565)3.20817703
13Elevated erythrocyte sedimentation rate (HP:0003565)3.19873156
14Hypoproteinemia (HP:0003075)3.17769661
15IgG deficiency (HP:0004315)3.16506795
16Renal Fanconi syndrome (HP:0001994)3.07931213
17Lipid accumulation in hepatocytes (HP:0006561)3.06166995
18Aplastic anemia (HP:0001915)3.01820685
19Increased intramyocellular lipid droplets (HP:0012240)2.95111596
20Pancreatic cysts (HP:0001737)2.89812906
21Abnormality of T cell number (HP:0011839)2.85417412
22T lymphocytopenia (HP:0005403)2.73259043
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72074514
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72074514
25Autoimmune hemolytic anemia (HP:0001890)2.68658989
26Decreased electroretinogram (ERG) amplitude (HP:0000654)2.61923512
27Cerebral edema (HP:0002181)2.55625839
28Abnormal rod and cone electroretinograms (HP:0008323)2.53539123
29Severe combined immunodeficiency (HP:0004430)2.52527439
30Increased muscle lipid content (HP:0009058)2.51246599
31Methylmalonic acidemia (HP:0002912)2.51126867
32Thyroiditis (HP:0100646)2.49399660
33Abnormality of B cell number (HP:0010975)2.48006324
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.47845847
35Methylmalonic aciduria (HP:0012120)2.47599434
36Type I transferrin isoform profile (HP:0003642)2.42553201
37Exertional dyspnea (HP:0002875)2.41891862
38Abolished electroretinogram (ERG) (HP:0000550)2.41683430
39Abnormality of the prostate (HP:0008775)2.40764798
40Increased serum lactate (HP:0002151)2.39996242
41Attenuation of retinal blood vessels (HP:0007843)2.39918643
42Pancreatic fibrosis (HP:0100732)2.37971385
43Lactic acidosis (HP:0003128)2.37619217
44Abnormality of midbrain morphology (HP:0002418)2.36036023
45Molar tooth sign on MRI (HP:0002419)2.36036023
46True hermaphroditism (HP:0010459)2.35812737
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35802651
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31053504
49Abnormality of the renal cortex (HP:0011035)2.29110247
50Abnormality of T cells (HP:0002843)2.28250803
51Renal cortical cysts (HP:0000803)2.26016809
52Optic disc pallor (HP:0000543)2.25321652
53Generalized aminoaciduria (HP:0002909)2.24653506
54Lethargy (HP:0001254)2.18442648
55Decreased central vision (HP:0007663)2.17470235
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16506449
57Abnormal protein N-linked glycosylation (HP:0012347)2.16506449
58Abnormal protein glycosylation (HP:0012346)2.16506449
59Abnormal glycosylation (HP:0012345)2.16506449
60Increased IgM level (HP:0003496)2.16449012
61Respiratory failure (HP:0002878)2.16249401
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13747270
63Dicarboxylic aciduria (HP:0003215)2.13747270
64Hypothermia (HP:0002045)2.12889381
65Glycosuria (HP:0003076)2.11958204
66Abnormality of urine glucose concentration (HP:0011016)2.11958204
67Ketosis (HP:0001946)2.11689920
68Hypoalbuminemia (HP:0003073)2.11091101
69Abnormal albumin level (HP:0012116)2.11091101
70Chronic diarrhea (HP:0002028)2.08245514
71Abnormality of eosinophils (HP:0001879)2.05336000
72Ketoacidosis (HP:0001993)2.04757171
73Abnormality of renal resorption (HP:0011038)2.01803682
74Aplasia/hypoplasia of the uterus (HP:0008684)2.00648718
75B lymphocytopenia (HP:0010976)1.96517374
76Vacuolated lymphocytes (HP:0001922)1.94093952
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92939486
78Abnormality of alanine metabolism (HP:0010916)1.92939486
79Hyperalaninemia (HP:0003348)1.92939486
80Combined immunodeficiency (HP:0005387)1.91639048
81Autoimmune thrombocytopenia (HP:0001973)1.90163226
82Eosinophilia (HP:0001880)1.88255883
83Congenital, generalized hypertrichosis (HP:0004540)1.84752162
84Medial flaring of the eyebrow (HP:0010747)1.84696339
85Type II lissencephaly (HP:0007260)1.83515581
86Pancytopenia (HP:0001876)1.82601078
87Abnormal drinking behavior (HP:0030082)1.81817731
88Polydipsia (HP:0001959)1.81817731
89Nephronophthisis (HP:0000090)1.81456873
90Abnormal delayed hypersensitivity skin test (HP:0002963)1.80552209
91Exercise intolerance (HP:0003546)1.76273397
92Abnormality of vitamin B metabolism (HP:0004340)1.74711810
93Petechiae (HP:0000967)1.72966029
94Constricted visual fields (HP:0001133)1.72522025
95Severe visual impairment (HP:0001141)1.72203858
96Leukocytosis (HP:0001974)1.70640521
97CNS demyelination (HP:0007305)1.70527519
98Pulmonary infiltrates (HP:0002113)1.69710657
99Abnormality of transition element cation homeostasis (HP:0011030)1.69593277
100Myositis (HP:0100614)1.67989039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.20379011
2KDR3.26987822
3MAP4K23.21398086
4TESK23.21206308
5VRK23.02017451
6FRK2.99940840
7BCKDK2.90091648
8ADRBK22.63585550
9TAOK32.57743654
10MST42.40437855
11ZAK2.35015902
12GRK12.31358475
13NUAK12.17987194
14MAP3K121.92574747
15TLK11.89556068
16ITK1.77247633
17MAP4K11.54999581
18VRK11.49056361
19BMPR1B1.46795666
20EIF2AK31.46618107
21PINK11.46224818
22LIMK11.44111236
23TEC1.38601829
24TESK11.36604348
25TIE11.26988364
26IKBKB1.25884679
27WNK41.25399781
28GRK71.24299397
29SYK1.22822371
30INSRR1.22621324
31MAPKAPK31.21274429
32MYLK1.18329179
33FES1.15749317
34TRIM281.11726807
35KIT1.05648254
36MAP2K61.02452020
37WNK30.99247453
38BMPR20.98154554
39MUSK0.98040455
40PRKCQ0.96103109
41DAPK20.93677701
42GRK60.90412236
43TNK20.90138426
44CAMKK20.90122204
45OXSR10.89781576
46DAPK10.87734222
47EIF2AK10.85981599
48LCK0.83108945
49LYN0.82144966
50CSF1R0.78621124
51CSNK1G30.77612782
52PIK3CG0.75541934
53ADRBK10.74882403
54IKBKE0.74176391
55STK160.72953415
56PIM20.70520437
57JAK30.68817685
58PRKCE0.66889120
59PHKG20.66567406
60PHKG10.66567406
61RPS6KA50.66438336
62TBK10.62535972
63CSNK1G10.62214052
64BTK0.61871655
65PASK0.59240050
66CSNK1G20.58619751
67PIK3CA0.57693483
68PLK20.56504909
69STK390.55892607
70GRK50.52952692
71MAPK130.52559322
72NME10.52015807
73TRPM70.50950445
74MATK0.49659625
75ZAP700.49144322
76IGF1R0.48385746
77PRKCA0.47900454
78BUB10.47065939
79MAP3K110.45726808
80ERBB30.45238411
81SCYL20.43526227
82MAPKAPK50.43408058
83MAP2K70.43292700
84CSK0.43277036
85FLT30.41875060
86CSNK1A1L0.40883522
87PDK20.40757070
88OBSCN0.40592928
89DAPK30.39986092
90PRKACA0.39777122
91PAK30.38931915
92PRKCG0.35676172
93BRSK20.34590018
94PRKCI0.34344199
95CSNK1A10.32804939
96ACVR1B0.31763287
97CAMK2A0.31605671
98DYRK20.31272462
99CSNK2A10.31064646
100ABL20.30619860

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.74999684
2Oxidative phosphorylation_Homo sapiens_hsa001903.36100396
3Primary immunodeficiency_Homo sapiens_hsa053403.13032950
4Allograft rejection_Homo sapiens_hsa053302.83408179
5Graft-versus-host disease_Homo sapiens_hsa053322.83303747
6Autoimmune thyroid disease_Homo sapiens_hsa053202.78371789
7Type I diabetes mellitus_Homo sapiens_hsa049402.72906083
8Parkinsons disease_Homo sapiens_hsa050122.59318250
9Asthma_Homo sapiens_hsa053102.49109967
10Protein export_Homo sapiens_hsa030602.36172710
11Antigen processing and presentation_Homo sapiens_hsa046122.30739338
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.13087684
13Rheumatoid arthritis_Homo sapiens_hsa053232.11479562
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04829791
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93002445
16Hematopoietic cell lineage_Homo sapiens_hsa046401.75811693
17RNA polymerase_Homo sapiens_hsa030201.71478908
18Alzheimers disease_Homo sapiens_hsa050101.64791753
19Phototransduction_Homo sapiens_hsa047441.63311518
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59581422
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.55296419
22Ribosome_Homo sapiens_hsa030101.47604150
23Caffeine metabolism_Homo sapiens_hsa002321.47327476
24Sulfur metabolism_Homo sapiens_hsa009201.45351173
25Huntingtons disease_Homo sapiens_hsa050161.43981140
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42152997
27Collecting duct acid secretion_Homo sapiens_hsa049661.31569297
28Nitrogen metabolism_Homo sapiens_hsa009101.30998137
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28182108
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24103385
31Peroxisome_Homo sapiens_hsa041461.21700708
32Linoleic acid metabolism_Homo sapiens_hsa005911.21160456
33Tryptophan metabolism_Homo sapiens_hsa003801.16611229
34Cardiac muscle contraction_Homo sapiens_hsa042601.12566949
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12118949
36Butanoate metabolism_Homo sapiens_hsa006501.12045383
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10052375
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09903425
39Staphylococcus aureus infection_Homo sapiens_hsa051501.08762400
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07544078
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99274689
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97391487
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97347121
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95204782
45Propanoate metabolism_Homo sapiens_hsa006400.93662010
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.92796711
47Chemical carcinogenesis_Homo sapiens_hsa052040.91465570
48Homologous recombination_Homo sapiens_hsa034400.86633733
49One carbon pool by folate_Homo sapiens_hsa006700.84028049
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83185981
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82434366
52RNA degradation_Homo sapiens_hsa030180.80432899
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77677052
54Arachidonic acid metabolism_Homo sapiens_hsa005900.76668825
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.76354907
56Pyrimidine metabolism_Homo sapiens_hsa002400.75620765
57Retinol metabolism_Homo sapiens_hsa008300.75048849
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72797214
59Regulation of autophagy_Homo sapiens_hsa041400.72617672
60Fatty acid elongation_Homo sapiens_hsa000620.72271003
61Viral myocarditis_Homo sapiens_hsa054160.70852310
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69587869
63T cell receptor signaling pathway_Homo sapiens_hsa046600.69405597
64Purine metabolism_Homo sapiens_hsa002300.68606977
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.68091092
66Selenocompound metabolism_Homo sapiens_hsa004500.66381116
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65647975
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64329128
69Ether lipid metabolism_Homo sapiens_hsa005650.63335085
70Systemic lupus erythematosus_Homo sapiens_hsa053220.61836730
71Metabolic pathways_Homo sapiens_hsa011000.58509367
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57621624
73Olfactory transduction_Homo sapiens_hsa047400.56744083
74Basal transcription factors_Homo sapiens_hsa030220.56323846
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53656468
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53557750
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53182350
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.51528225
79Mineral absorption_Homo sapiens_hsa049780.49638405
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48237902
81Glutathione metabolism_Homo sapiens_hsa004800.48152274
82Leishmaniasis_Homo sapiens_hsa051400.46701449
83Legionellosis_Homo sapiens_hsa051340.46192498
84Malaria_Homo sapiens_hsa051440.43753164
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43249510
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40978798
87Folate biosynthesis_Homo sapiens_hsa007900.40710055
88Lysosome_Homo sapiens_hsa041420.40048940
89Measles_Homo sapiens_hsa051620.39623758
90Salmonella infection_Homo sapiens_hsa051320.38677280
91Fanconi anemia pathway_Homo sapiens_hsa034600.37765235
92beta-Alanine metabolism_Homo sapiens_hsa004100.37186157
93Herpes simplex infection_Homo sapiens_hsa051680.34601673
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34242510
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28930096
96Fat digestion and absorption_Homo sapiens_hsa049750.28482874
97Pertussis_Homo sapiens_hsa051330.28438259
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.27401522
99Fatty acid degradation_Homo sapiens_hsa000710.26439171
100Nucleotide excision repair_Homo sapiens_hsa034200.24900261

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