FTLP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.28212020
2cytidine deamination (GO:0009972)6.48532841
3cytidine metabolic process (GO:0046087)6.48532841
4cytidine catabolic process (GO:0006216)6.48532841
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.71531545
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.59132197
7immunoglobulin mediated immune response (GO:0016064)3.96918681
8regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.66719252
9response to interferon-beta (GO:0035456)3.65138091
10regulation of regulatory T cell differentiation (GO:0045589)3.56828997
11eosinophil chemotaxis (GO:0048245)3.51667450
12cellular response to interleukin-15 (GO:0071350)3.50148575
13platelet dense granule organization (GO:0060155)3.49083671
14piRNA metabolic process (GO:0034587)3.32395627
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28646886
16ATP synthesis coupled proton transport (GO:0015986)3.28646886
17B cell mediated immunity (GO:0019724)3.27551822
18positive regulation of defense response to virus by host (GO:0002230)3.26854040
19regulation of chronic inflammatory response (GO:0002676)3.26846003
20cellular response to interferon-beta (GO:0035458)3.21166148
21S-adenosylmethionine metabolic process (GO:0046500)3.20583226
22eosinophil migration (GO:0072677)3.17648041
23positive thymic T cell selection (GO:0045059)3.13553078
24water-soluble vitamin biosynthetic process (GO:0042364)3.07125904
25negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.05503222
26pyrimidine nucleoside catabolic process (GO:0046135)3.02875210
27positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.00318461
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00036386
29regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.98293303
30respiratory chain complex IV assembly (GO:0008535)2.94696043
31regulation of cellular amino acid metabolic process (GO:0006521)2.89164350
32regulation of interleukin-8 secretion (GO:2000482)2.87571702
33regulation of activation of Janus kinase activity (GO:0010533)2.86852880
34T cell costimulation (GO:0031295)2.85829707
35lymphocyte costimulation (GO:0031294)2.84906604
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.84228437
37negative regulation of mast cell activation (GO:0033004)2.81837595
38positive T cell selection (GO:0043368)2.81551023
39xenobiotic catabolic process (GO:0042178)2.77576385
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71636718
41positive regulation of T cell mediated cytotoxicity (GO:0001916)2.68448236
42positive regulation of monocyte chemotaxis (GO:0090026)2.66937798
43positive regulation of calcium-mediated signaling (GO:0050850)2.66771036
44positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.66735522
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64712472
46negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.63868455
47positive regulation of interleukin-8 secretion (GO:2000484)2.63807130
48interferon-gamma-mediated signaling pathway (GO:0060333)2.62026455
49autophagic vacuole fusion (GO:0000046)2.60475582
50proteasome assembly (GO:0043248)2.59707574
51positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.59270102
52protein neddylation (GO:0045116)2.57829383
53negative regulation of viral genome replication (GO:0045071)2.57273578
54regulation of inflammatory response to antigenic stimulus (GO:0002861)2.56949706
55fucose catabolic process (GO:0019317)2.56689037
56L-fucose metabolic process (GO:0042354)2.56689037
57L-fucose catabolic process (GO:0042355)2.56689037
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56361045
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56361045
60phosphatidylinositol acyl-chain remodeling (GO:0036149)2.56098350
61regulation of T cell mediated cytotoxicity (GO:0001914)2.54078825
62organelle membrane fusion (GO:0090174)2.52872094
63mannosylation (GO:0097502)2.52291280
64regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.51840326
65positive regulation of lymphocyte migration (GO:2000403)2.50971484
66response to interleukin-15 (GO:0070672)2.50436542
67negative regulation by host of viral transcription (GO:0043922)2.50282266
68positive regulation of prostaglandin secretion (GO:0032308)2.49810300
69positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.49339083
70positive regulation of alpha-beta T cell proliferation (GO:0046641)2.48648054
71rRNA catabolic process (GO:0016075)2.48435407
72electron transport chain (GO:0022900)2.48276236
73behavioral response to nicotine (GO:0035095)2.48124582
74respiratory electron transport chain (GO:0022904)2.46909104
75cellular ketone body metabolic process (GO:0046950)2.46297844
76RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44530614
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43754128
78cellular response to zinc ion (GO:0071294)2.39742311
79macrophage chemotaxis (GO:0048246)2.38856643
80signal peptide processing (GO:0006465)2.36939164
81protein complex biogenesis (GO:0070271)2.36324585
82cytochrome complex assembly (GO:0017004)2.34424542
83positive regulation of uterine smooth muscle contraction (GO:0070474)2.33855524
84cellular response to interferon-gamma (GO:0071346)2.33526013
85indole-containing compound catabolic process (GO:0042436)2.33486989
86indolalkylamine catabolic process (GO:0046218)2.33486989
87tryptophan catabolic process (GO:0006569)2.33486989
88inositol phosphate dephosphorylation (GO:0046855)2.32732099
89phosphorylated carbohydrate dephosphorylation (GO:0046838)2.32732099
90regulation of T cell receptor signaling pathway (GO:0050856)2.32624908
91positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.32380789
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.32364535
93T cell receptor signaling pathway (GO:0050852)2.31238138
94negative regulation of T cell apoptotic process (GO:0070233)2.30235704
95response to interferon-gamma (GO:0034341)2.30050610
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.29315493
97positive regulation of activated T cell proliferation (GO:0042104)2.29117468
98proton transport (GO:0015992)2.28059328
99regulation of antigen processing and presentation (GO:0002577)2.27735651
100preassembly of GPI anchor in ER membrane (GO:0016254)2.27515367

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.06000862
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.58722635
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.97947377
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.96846124
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.58229240
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.81915762
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75356937
8VDR_22108803_ChIP-Seq_LS180_Human2.48711567
9ZNF274_21170338_ChIP-Seq_K562_Hela2.45249335
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43152462
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.32582833
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.26023194
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24562608
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10839499
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.10473562
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06708237
17VDR_23849224_ChIP-Seq_CD4+_Human2.01352060
18SRF_21415370_ChIP-Seq_HL-1_Mouse1.93264080
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86401775
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76261144
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76041366
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.73202441
23TP53_22573176_ChIP-Seq_HFKS_Human1.66128561
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66116441
25FOXP3_21729870_ChIP-Seq_TREG_Human1.62656607
26GATA3_26560356_Chip-Seq_TH2_Human1.59622571
27FOXA1_27270436_Chip-Seq_PROSTATE_Human1.59495366
28FOXA1_25329375_ChIP-Seq_VCAP_Human1.59495366
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54023318
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48423042
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.43533266
32HTT_18923047_ChIP-ChIP_STHdh_Human1.43192550
33AR_20517297_ChIP-Seq_VCAP_Human1.42555640
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.42147676
35GATA3_21878914_ChIP-Seq_MCF-7_Human1.38832709
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38615636
37TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.35877704
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34994244
39SOX2_19829295_ChIP-Seq_ESCs_Human1.33287598
40NANOG_19829295_ChIP-Seq_ESCs_Human1.33287598
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31656602
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30707645
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30642040
44FOXH1_21741376_ChIP-Seq_EPCs_Human1.30583402
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29486963
46MYB_26560356_Chip-Seq_TH2_Human1.28180250
47GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.27851929
48TAF2_19829295_ChIP-Seq_ESCs_Human1.27767848
49FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27097673
50ER_23166858_ChIP-Seq_MCF-7_Human1.25982936
51CIITA_25753668_ChIP-Seq_RAJI_Human1.25368208
52ELK1_19687146_ChIP-ChIP_HELA_Human1.25245741
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22196051
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21975950
55GATA3_27048872_Chip-Seq_THYMUS_Human1.21606277
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20064104
57NCOR_22424771_ChIP-Seq_293T_Human1.16290791
58IRF1_19129219_ChIP-ChIP_H3396_Human1.13019600
59NANOG_20526341_ChIP-Seq_ESCs_Human1.11846329
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10445329
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06914518
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05999153
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04400383
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.03847394
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03351339
66MYC_18940864_ChIP-ChIP_HL60_Human1.03186086
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02492395
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02433417
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00946265
70HOXB7_26014856_ChIP-Seq_BT474_Human1.00904772
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99785559
72CBP_20019798_ChIP-Seq_JUKART_Human0.99785559
73GATA3_26560356_Chip-Seq_TH1_Human0.99753966
74MYC_19829295_ChIP-Seq_ESCs_Human0.99644231
75P53_21459846_ChIP-Seq_SAOS-2_Human0.98963383
76RBPJ_21746931_ChIP-Seq_IB4_Human0.97822428
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97807222
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97771313
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97651626
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97122880
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97111059
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96398503
83GATA6_21074721_ChIP-Seq_CACO-2_Human0.96061795
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95692589
85ERG_20517297_ChIP-Seq_VCAP_Human0.95449804
86CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95380057
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94555489
88IGF1R_20145208_ChIP-Seq_DFB_Human0.93732926
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92628585
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92282969
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91924918
92CDX2_22108803_ChIP-Seq_LS180_Human0.91857957
93P300_19829295_ChIP-Seq_ESCs_Human0.91409495
94ERA_21632823_ChIP-Seq_H3396_Human0.91199254
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91169840
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91112155
97RUNX_20019798_ChIP-Seq_JUKART_Human0.90755682
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90555971
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90478461
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.90345194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.94786578
2MP0005360_urolithiasis3.50096679
3MP0001835_abnormal_antigen_presentation3.33897232
4MP0003806_abnormal_nucleotide_metabolis2.82228488
5MP0002148_abnormal_hypersensitivity_rea2.63143780
6MP0009785_altered_susceptibility_to2.41271866
7MP0005075_abnormal_melanosome_morpholog2.24803626
8MP0005645_abnormal_hypothalamus_physiol2.08152568
9MP0005000_abnormal_immune_tolerance2.04356492
10MP0001800_abnormal_humoral_immune1.98529602
11MP0002876_abnormal_thyroid_physiology1.96473046
12MP0008875_abnormal_xenobiotic_pharmacok1.95914870
13MP0000685_abnormal_immune_system1.83723275
14MP0002139_abnormal_hepatobiliary_system1.82555787
15MP0002837_dystrophic_cardiac_calcinosis1.81988735
16MP0006082_CNS_inflammation1.79627010
17MP0009333_abnormal_splenocyte_physiolog1.77526663
18MP0002723_abnormal_immune_serum1.73576023
19MP0002166_altered_tumor_susceptibility1.72931968
20MP0005646_abnormal_pituitary_gland1.68881524
21MP0001790_abnormal_immune_system1.68578773
22MP0005387_immune_system_phenotype1.68578773
23MP0003724_increased_susceptibility_to1.67368546
24MP0005174_abnormal_tail_pigmentation1.64562505
25MP0003195_calcinosis1.64050959
26MP0002420_abnormal_adaptive_immunity1.64027784
27MP0005464_abnormal_platelet_physiology1.63680536
28MP0003866_abnormal_defecation1.63190725
29MP0009764_decreased_sensitivity_to1.62009624
30MP0001819_abnormal_immune_cell1.60530309
31MP0002452_abnormal_antigen_presenting1.60122874
32MP0004145_abnormal_muscle_electrophysio1.60018517
33MP0001501_abnormal_sleep_pattern1.50275473
34MP0001873_stomach_inflammation1.47806203
35MP0002006_tumorigenesis1.44669042
36MP0003786_premature_aging1.43264414
37MP0001845_abnormal_inflammatory_respons1.38587765
38MP0004147_increased_porphyrin_level1.37559429
39MP0003646_muscle_fatigue1.36781022
40MP0000372_irregular_coat_pigmentation1.36669794
41MP0005025_abnormal_response_to1.33671735
42MP0005084_abnormal_gallbladder_morpholo1.33459331
43MP0005332_abnormal_amino_acid1.33032120
44MP0010155_abnormal_intestine_physiology1.33007718
45MP0008872_abnormal_physiological_respon1.32933987
46MP0000569_abnormal_digit_pigmentation1.29328858
47MP0005551_abnormal_eye_electrophysiolog1.27468608
48MP0002138_abnormal_hepatobiliary_system1.27200455
49MP0006072_abnormal_retinal_apoptosis1.27165092
50MP0008877_abnormal_DNA_methylation1.24013971
51MP0001968_abnormal_touch/_nociception1.23192733
52MP0002102_abnormal_ear_morphology1.21099268
53MP0003075_altered_response_to1.19972683
54MP0002693_abnormal_pancreas_physiology1.19041334
55MP0005365_abnormal_bile_salt1.18578098
56MP0002419_abnormal_innate_immunity1.16186356
57MP0008469_abnormal_protein_level1.15898840
58MP0001986_abnormal_taste_sensitivity1.15036670
59MP0000538_abnormal_urinary_bladder1.14590065
60MP0000015_abnormal_ear_pigmentation1.13326345
61MP0006036_abnormal_mitochondrial_physio1.12520064
62MP0001756_abnormal_urination1.10102666
63MP0000716_abnormal_immune_system1.07643975
64MP0005636_abnormal_mineral_homeostasis1.06941803
65MP0001905_abnormal_dopamine_level1.06887941
66MP0005165_increased_susceptibility_to1.05709600
67MP0001765_abnormal_ion_homeostasis1.02891656
68MP0008775_abnormal_heart_ventricle1.02850344
69MP0002398_abnormal_bone_marrow1.02619832
70MP0010386_abnormal_urinary_bladder1.02059635
71MP0009643_abnormal_urine_homeostasis1.01919475
72MP0003045_fibrosis1.00966329
73MP0001853_heart_inflammation1.00557665
74MP0010329_abnormal_lipoprotein_level0.99996414
75MP0008007_abnormal_cellular_replicative0.98446837
76MP0003011_delayed_dark_adaptation0.96877508
77MP0003436_decreased_susceptibility_to0.96459469
78MP0000689_abnormal_spleen_morphology0.95963117
79MP0006054_spinal_hemorrhage0.93591236
80MP0002909_abnormal_adrenal_gland0.93420414
81MP0003186_abnormal_redox_activity0.92279124
82MP0005389_reproductive_system_phenotype0.90280702
83MP0006035_abnormal_mitochondrial_morpho0.89903151
84MP0002736_abnormal_nociception_after0.89256697
85MP0004885_abnormal_endolymph0.88580269
86MP0003172_abnormal_lysosome_physiology0.87948416
87MP0001666_abnormal_nutrient_absorption0.86842321
88MP0003763_abnormal_thymus_physiology0.86691387
89MP0002429_abnormal_blood_cell0.86138787
90MP0003252_abnormal_bile_duct0.86020340
91MP0000013_abnormal_adipose_tissue0.85860184
92MP0002277_abnormal_respiratory_mucosa0.84764931
93MP0005367_renal/urinary_system_phenotyp0.84180158
94MP0000516_abnormal_urinary_system0.84180158
95MP0000427_abnormal_hair_cycle0.83511256
96MP0005410_abnormal_fertilization0.82707113
97MP0008995_early_reproductive_senescence0.82604387
98MP0009763_increased_sensitivity_to0.82581704
99MP0001919_abnormal_reproductive_system0.81640758
100MP0001984_abnormal_olfaction0.81207487

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)3.54693624
2Increased hepatocellular lipid droplets (HP:0006565)3.20136555
3Hypoproteinemia (HP:0003075)3.15645540
4IgG deficiency (HP:0004315)3.13392744
5Abnormality of the prostate (HP:0008775)3.12478590
6Increased CSF lactate (HP:0002490)3.11271542
7Mitochondrial inheritance (HP:0001427)3.10342518
8Increased intramyocellular lipid droplets (HP:0012240)3.07660924
9Lipid accumulation in hepatocytes (HP:0006561)3.06318611
10Aplastic anemia (HP:0001915)3.06019187
11Acute necrotizing encephalopathy (HP:0006965)2.97312294
12Hepatic necrosis (HP:0002605)2.95416819
13Methylmalonic acidemia (HP:0002912)2.93662089
14Stomatitis (HP:0010280)2.93189585
15Abolished electroretinogram (ERG) (HP:0000550)2.88828424
16Pancreatic cysts (HP:0001737)2.87732652
17Abnormality of T cell number (HP:0011839)2.87074302
18Progressive macrocephaly (HP:0004481)2.86880538
19Abnormal mitochondria in muscle tissue (HP:0008316)2.81183435
20Hepatocellular necrosis (HP:0001404)2.80639341
21Renal Fanconi syndrome (HP:0001994)2.79829582
22Abnormality of the renal cortex (HP:0011035)2.77231010
23T lymphocytopenia (HP:0005403)2.76235223
24Pancreatic fibrosis (HP:0100732)2.65432106
25Congenital stationary night blindness (HP:0007642)2.64371398
26Acute encephalopathy (HP:0006846)2.63716153
27Renal cortical cysts (HP:0000803)2.62841433
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60254078
29Abnormality of alanine metabolism (HP:0010916)2.60254078
30Hyperalaninemia (HP:0003348)2.60254078
31Increased muscle lipid content (HP:0009058)2.60060603
32Increased serum lactate (HP:0002151)2.58768299
33Exertional dyspnea (HP:0002875)2.58256109
34Methylmalonic aciduria (HP:0012120)2.55818402
35Tongue fasciculations (HP:0001308)2.51121164
363-Methylglutaconic aciduria (HP:0003535)2.49688385
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45042166
38Glycosuria (HP:0003076)2.39863558
39Abnormality of urine glucose concentration (HP:0011016)2.39863558
40Chronic diarrhea (HP:0002028)2.36167605
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33962687
42Attenuation of retinal blood vessels (HP:0007843)2.30308175
43True hermaphroditism (HP:0010459)2.29215224
44Type I transferrin isoform profile (HP:0003642)2.26692659
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.26083177
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.26083177
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25354382
48Abnormality of T cells (HP:0002843)2.20772240
49Lactic acidosis (HP:0003128)2.20554661
50Nephronophthisis (HP:0000090)2.19976799
51Generalized aminoaciduria (HP:0002909)2.16214450
52Thyroiditis (HP:0100646)2.16187452
53Increased IgM level (HP:0003496)2.15891893
54Ketoacidosis (HP:0001993)2.13069389
55Abnormality of vitamin B metabolism (HP:0004340)2.09792292
56Aplasia/hypoplasia of the uterus (HP:0008684)2.09704003
57Dicarboxylic aciduria (HP:0003215)2.08565364
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08565364
59Pancytopenia (HP:0001876)2.07176996
60Hypothermia (HP:0002045)2.04510497
61Hypoalbuminemia (HP:0003073)2.03979675
62Abnormal albumin level (HP:0012116)2.03979675
63Muscle fibrillation (HP:0010546)2.03059787
64Pulmonary fibrosis (HP:0002206)2.02482887
65Congenital, generalized hypertrichosis (HP:0004540)2.02185097
66Ketosis (HP:0001946)1.99170124
67Lethargy (HP:0001254)1.98338073
68Abnormality of the renal medulla (HP:0100957)1.96845318
69Abnormality of glycolipid metabolism (HP:0010969)1.96621319
70Abnormality of liposaccharide metabolism (HP:0010968)1.96621319
71Abnormality of glycosphingolipid metabolism (HP:0004343)1.96621319
72Abnormality of B cell number (HP:0010975)1.93903420
73Pulmonary infiltrates (HP:0002113)1.93134816
74Abnormality of midbrain morphology (HP:0002418)1.92854623
75Molar tooth sign on MRI (HP:0002419)1.92854623
76Abnormality of transition element cation homeostasis (HP:0011030)1.92832653
77Optic disc pallor (HP:0000543)1.91601063
78Pendular nystagmus (HP:0012043)1.91128228
79Autoimmune hemolytic anemia (HP:0001890)1.88841312
80Abnormal protein glycosylation (HP:0012346)1.88336389
81Abnormal glycosylation (HP:0012345)1.88336389
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88336389
83Abnormal protein N-linked glycosylation (HP:0012347)1.88336389
84Abnormal rod and cone electroretinograms (HP:0008323)1.85930444
85Hemoptysis (HP:0002105)1.85786680
86Abnormality of the vitamin B12 metabolism (HP:0004341)1.84873550
87Severe visual impairment (HP:0001141)1.84824436
88Polydipsia (HP:0001959)1.83941202
89Abnormal drinking behavior (HP:0030082)1.83941202
90Decreased central vision (HP:0007663)1.82853766
91Albinism (HP:0001022)1.81189639
92Alveolar cell carcinoma (HP:0006519)1.80809906
93Cerebral edema (HP:0002181)1.78231374
94Keratoconus (HP:0000563)1.76347351
95Increased corneal curvature (HP:0100692)1.76347351
96Abnormality of the pleura (HP:0002103)1.75869876
97Respiratory failure (HP:0002878)1.74361801
98Severe combined immunodeficiency (HP:0004430)1.74044976
99Abnormal biliary tract physiology (HP:0012439)1.73320745
100Bile duct proliferation (HP:0001408)1.73320745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.34526578
2FRK3.51937330
3TLK12.90780876
4TIE12.73662459
5KDR2.72484473
6ADRBK22.69898081
7TAOK32.65773823
8GRK12.62163623
9NUAK12.59595759
10BMPR1B2.50830697
11MST42.19338271
12BCKDK2.16340935
13MAP4K22.05530376
14MAP4K11.97798733
15ZAK1.94967070
16ITK1.88052054
17TEC1.82663748
18FES1.82501195
19VRK21.69370991
20MAP3K121.64193804
21MAPKAPK31.54959562
22OXSR11.50088555
23SYK1.49828230
24KIT1.47064675
25PINK11.45387418
26MAP2K61.40827315
27CDK191.39031457
28EIF2AK31.38099918
29PHKG11.30288040
30PHKG21.30288040
31FLT31.29998542
32BMPR21.24577314
33EIF2AK11.24527113
34CSF1R1.24404173
35GRK71.24330859
36IKBKB1.23461491
37MYLK1.23168949
38DAPK21.19544253
39TESK21.16039285
40INSRR1.12363025
41WNK41.10389374
42TRIM281.02251075
43TRPM70.99836644
44DAPK10.98682525
45VRK10.93830504
46CDK80.92854062
47PRKCQ0.91815512
48RIPK40.88676837
49TGFBR10.88395421
50LYN0.82992775
51RPS6KA50.82376483
52BTK0.80230939
53CSNK1G30.80038464
54LCK0.77040774
55WNK30.76331734
56JAK30.76196953
57MAP3K140.73212896
58CSNK1G10.72770258
59TBK10.72373243
60CSNK1G20.66968264
61ADRBK10.66539095
62PRKCE0.61723683
63PIK3CA0.61629576
64IKBKE0.59396226
65GRK50.58318800
66LIMK10.57633398
67PTK2B0.57560923
68CSK0.54651977
69ACVR1B0.54380529
70ABL10.52288552
71PRKCA0.52260138
72MKNK20.51788233
73MAPKAPK50.51429079
74TNK20.51366011
75HCK0.50951563
76SIK30.49950028
77CAMK2D0.49311055
78IGF1R0.47888447
79OBSCN0.46904417
80CHUK0.46322290
81STK390.45903698
82PIK3CG0.44738803
83GRK60.44274830
84BUB10.44252867
85ERBB30.43935456
86JAK20.42678143
87PLK20.41217594
88FER0.41029227
89STK160.40601498
90PRKCG0.40509379
91PRKCI0.38667889
92PRKACA0.37374814
93CAMK2A0.36807229
94DAPK30.34849133
95MKNK10.34819612
96CSNK1A10.29409452
97PRKCD0.29005483
98CSNK1A1L0.28099765
99EGFR0.27548699
100PRKAA20.27080245

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.42420746
2Allograft rejection_Homo sapiens_hsa053304.15196764
3Autoimmune thyroid disease_Homo sapiens_hsa053204.04221633
4Graft-versus-host disease_Homo sapiens_hsa053323.92378167
5Type I diabetes mellitus_Homo sapiens_hsa049403.90994083
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.39825267
7Antigen processing and presentation_Homo sapiens_hsa046122.76758505
8Proteasome_Homo sapiens_hsa030502.68026153
9Primary immunodeficiency_Homo sapiens_hsa053402.39184675
10Rheumatoid arthritis_Homo sapiens_hsa053232.28368612
11Oxidative phosphorylation_Homo sapiens_hsa001902.25887622
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16656034
13Staphylococcus aureus infection_Homo sapiens_hsa051501.98537546
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94256573
15Hematopoietic cell lineage_Homo sapiens_hsa046401.77021851
16Parkinsons disease_Homo sapiens_hsa050121.70953294
17Protein export_Homo sapiens_hsa030601.62201707
18Viral myocarditis_Homo sapiens_hsa054161.54453500
19Nitrogen metabolism_Homo sapiens_hsa009101.53592778
20Linoleic acid metabolism_Homo sapiens_hsa005911.51005688
21RNA polymerase_Homo sapiens_hsa030201.49069077
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41950170
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38818091
24Leishmaniasis_Homo sapiens_hsa051401.33180577
25Sulfur metabolism_Homo sapiens_hsa009201.26869301
26Peroxisome_Homo sapiens_hsa041461.23933644
27Phototransduction_Homo sapiens_hsa047441.23631067
28One carbon pool by folate_Homo sapiens_hsa006701.20806824
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.18098127
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14375550
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07249281
32Butanoate metabolism_Homo sapiens_hsa006501.06317975
33Alzheimers disease_Homo sapiens_hsa050101.02839153
34Arachidonic acid metabolism_Homo sapiens_hsa005901.00671599
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00248470
36Regulation of autophagy_Homo sapiens_hsa041401.00094514
37Systemic lupus erythematosus_Homo sapiens_hsa053220.95596811
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91699178
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89050960
40Ether lipid metabolism_Homo sapiens_hsa005650.88979499
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85951824
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83869941
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80279988
44Propanoate metabolism_Homo sapiens_hsa006400.80276200
45Huntingtons disease_Homo sapiens_hsa050160.76686034
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74193858
47Chemical carcinogenesis_Homo sapiens_hsa052040.72057261
48Collecting duct acid secretion_Homo sapiens_hsa049660.71761459
49Homologous recombination_Homo sapiens_hsa034400.71577292
50Selenocompound metabolism_Homo sapiens_hsa004500.70804121
51Tryptophan metabolism_Homo sapiens_hsa003800.69632127
52RNA degradation_Homo sapiens_hsa030180.69521911
53Fatty acid elongation_Homo sapiens_hsa000620.64839668
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64257200
55Fat digestion and absorption_Homo sapiens_hsa049750.63270234
56Caffeine metabolism_Homo sapiens_hsa002320.62066281
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61754162
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60799725
59T cell receptor signaling pathway_Homo sapiens_hsa046600.60446567
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59789981
61Mineral absorption_Homo sapiens_hsa049780.55707670
62Cardiac muscle contraction_Homo sapiens_hsa042600.55697450
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55368314
64Purine metabolism_Homo sapiens_hsa002300.55084827
65Fanconi anemia pathway_Homo sapiens_hsa034600.53553771
66Ribosome_Homo sapiens_hsa030100.53549804
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.53358258
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52589291
69Herpes simplex infection_Homo sapiens_hsa051680.51601195
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.51096367
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47926047
72Retinol metabolism_Homo sapiens_hsa008300.47541828
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47033924
74Pyrimidine metabolism_Homo sapiens_hsa002400.43197990
75Tuberculosis_Homo sapiens_hsa051520.43088368
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.42849988
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42654864
78Legionellosis_Homo sapiens_hsa051340.41362337
79Phagosome_Homo sapiens_hsa041450.40756414
80Toxoplasmosis_Homo sapiens_hsa051450.39440328
81Metabolic pathways_Homo sapiens_hsa011000.35718393
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34753002
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.34090855
84Olfactory transduction_Homo sapiens_hsa047400.33812291
85Glutathione metabolism_Homo sapiens_hsa004800.32818625
86Lysosome_Homo sapiens_hsa041420.32587957
87Ovarian steroidogenesis_Homo sapiens_hsa049130.29900453
88Taste transduction_Homo sapiens_hsa047420.26260551
89ABC transporters_Homo sapiens_hsa020100.26122265
90Influenza A_Homo sapiens_hsa051640.25257825
91Measles_Homo sapiens_hsa051620.24817493
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24480284
93Salivary secretion_Homo sapiens_hsa049700.24401348
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22559698
95beta-Alanine metabolism_Homo sapiens_hsa004100.21021250
96Basal transcription factors_Homo sapiens_hsa030220.20600016
97Epstein-Barr virus infection_Homo sapiens_hsa051690.19926305
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.19897032
99Malaria_Homo sapiens_hsa051440.17621847
100Renin-angiotensin system_Homo sapiens_hsa046140.17295206

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