ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.68976587
2	negative regulation of telomere maintenance (GO:0032205)	4.19918859
3	protein complex biogenesis (GO:0070271)	3.98089823
4	platelet dense granule organization (GO:0060155)	3.93821240
5	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.90801201
6	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.72436998
7	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.72436998
8	NADH dehydrogenase complex assembly (GO:0010257)	3.72436998
9	mitochondrial respiratory chain complex assembly (GO:0033108)	3.70308141
10	respiratory chain complex IV assembly (GO:0008535)	3.67878638
11	centriole replication (GO:0007099)	3.52375669
12	response to pheromone (GO:0019236)	3.51889600
13	L-fucose catabolic process (GO:0042355)	3.48043840
14	fucose catabolic process (GO:0019317)	3.48043840
15	L-fucose metabolic process (GO:0042354)	3.48043840
16	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.44485248
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.44485248
18	thalamus development (GO:0021794)	3.43830690
19	epithelial cilium movement (GO:0003351)	3.39431582
20	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.37950629
21	base-excision repair, AP site formation (GO:0006285)	3.35184513
22	ATP synthesis coupled proton transport (GO:0015986)	3.33375083
23	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.33375083
24	cytochrome complex assembly (GO:0017004)	3.26674556
25	DNA deamination (GO:0045006)	3.22359308
26	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.21357549
27	piRNA metabolic process (GO:0034587)	3.20690434
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.18074716
29	protein-cofactor linkage (GO:0018065)	3.16795384
30	nonmotile primary cilium assembly (GO:0035058)	3.07292439
31	glycerophospholipid catabolic process (GO:0046475)	3.07276173
32	positive regulation of prostaglandin secretion (GO:0032308)	3.04373706
33	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.03204403
34	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.02421959
35	behavioral response to ethanol (GO:0048149)	3.01168016
36	kidney morphogenesis (GO:0060993)	3.01003877
37	reflex (GO:0060004)	3.00618795
38	neuronal action potential (GO:0019228)	2.95703710
39	indolalkylamine metabolic process (GO:0006586)	2.92504758
40	tryptophan catabolic process (GO:0006569)	2.90940969
41	indole-containing compound catabolic process (GO:0042436)	2.90940969
42	indolalkylamine catabolic process (GO:0046218)	2.90940969
43	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90890139
44	ubiquinone biosynthetic process (GO:0006744)	2.89685078
45	regulation of action potential (GO:0098900)	2.89571538
46	auditory receptor cell stereocilium organization (GO:0060088)	2.89490733
47	mannosylation (GO:0097502)	2.87055594
48	positive regulation of growth hormone secretion (GO:0060124)	2.85604948
49	synaptic transmission, cholinergic (GO:0007271)	2.85067405
50	cornea development in camera-type eye (GO:0061303)	2.84007922
51	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.82604159
52	regulation of hexokinase activity (GO:1903299)	2.80424883
53	regulation of glucokinase activity (GO:0033131)	2.80424883
54	cellular ketone body metabolic process (GO:0046950)	2.80238264
55	parturition (GO:0007567)	2.79094154
56	S-adenosylmethionine metabolic process (GO:0046500)	2.78097990
57	kynurenine metabolic process (GO:0070189)	2.76979815
58	peptidyl-histidine modification (GO:0018202)	2.75195433
59	detection of light stimulus involved in visual perception (GO:0050908)	2.75133378
60	detection of light stimulus involved in sensory perception (GO:0050962)	2.75133378
61	positive regulation of fatty acid transport (GO:2000193)	2.74975297
62	protein localization to cilium (GO:0061512)	2.74869329
63	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.71244665
64	pyrimidine nucleobase catabolic process (GO:0006208)	2.70859939
65	axoneme assembly (GO:0035082)	2.70720463
66	chaperone-mediated protein transport (GO:0072321)	2.70349844
67	inner ear receptor stereocilium organization (GO:0060122)	2.68584857
68	retinal cone cell development (GO:0046549)	2.65427302
69	electron transport chain (GO:0022900)	2.65183836
70	transmission of nerve impulse (GO:0019226)	2.65160173
71	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.64704974
72	cilium movement (GO:0003341)	2.64275884
73	ubiquinone metabolic process (GO:0006743)	2.63959132
74	neural tube formation (GO:0001841)	2.63666776
75	sulfation (GO:0051923)	2.63588980
76	protein polyglutamylation (GO:0018095)	2.62079359
77	ketone body metabolic process (GO:1902224)	2.61629813
78	tryptophan metabolic process (GO:0006568)	2.61249901
79	proton transport (GO:0015992)	2.59578666
80	hydrogen ion transmembrane transport (GO:1902600)	2.59495679
81	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.57517721
82	negative regulation of mast cell activation (GO:0033004)	2.57501999
83	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.57352853
84	respiratory electron transport chain (GO:0022904)	2.56846897
85	primary amino compound metabolic process (GO:1901160)	2.56410553
86	rhodopsin mediated signaling pathway (GO:0016056)	2.55912118
87	hydrogen transport (GO:0006818)	2.54792441
88	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.54739711
89	nephron epithelium morphogenesis (GO:0072088)	2.54643501
90	nephron tubule morphogenesis (GO:0072078)	2.54643501
91	cellular biogenic amine catabolic process (GO:0042402)	2.53505701
92	amine catabolic process (GO:0009310)	2.53505701
93	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.51198141
94	DNA methylation involved in gamete generation (GO:0043046)	2.50437325
95	protein neddylation (GO:0045116)	2.46521621
96	indole-containing compound metabolic process (GO:0042430)	2.45803821
97	somite development (GO:0061053)	2.45634112
98	water-soluble vitamin biosynthetic process (GO:0042364)	2.45136744
99	nucleobase catabolic process (GO:0046113)	2.43040320
100	spinal cord motor neuron differentiation (GO:0021522)	2.42929929

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.17935960
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.03746328
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.03273065
4	VDR_22108803_ChIP-Seq_LS180_Human	2.96571671
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.93999545
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.85261916
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.79460631
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.50169090
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40872056
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34334872
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.13469371
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13445434
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07945876
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.06014473
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.89658914
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89561394
17	P300_19829295_ChIP-Seq_ESCs_Human	1.86357455
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.84502308
19	EWS_26573619_Chip-Seq_HEK293_Human	1.83167482
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.78668929
21	FUS_26573619_Chip-Seq_HEK293_Human	1.78345855
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.76372186
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66828882
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.65447655
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64359531
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.63513913
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.63125917
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61823314
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.59133070
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.54416817
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.52613108
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.51016910
33	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.44281687
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.44281687
35	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42672585
36	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42672585
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41323786
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.40223955
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40081527
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.38398422
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38184766
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35870134
43	REST_21632747_ChIP-Seq_MESCs_Mouse	1.35224955
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35127651
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35127651
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34201721
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32654510
48	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.30389382
49	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.30272997
50	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30009438
51	AR_25329375_ChIP-Seq_VCAP_Human	1.29217495
52	TCF4_23295773_ChIP-Seq_U87_Human	1.28057288
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27877152
54	STAT3_23295773_ChIP-Seq_U87_Human	1.27087882
55	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26328735
56	HOXB7_26014856_ChIP-Seq_BT474_Human	1.26084140
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22447992
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22151237
59	NCOR_22424771_ChIP-Seq_293T_Human	1.20947983
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.20421626
61	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.19938994
62	AR_20517297_ChIP-Seq_VCAP_Human	1.19797902
63	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19507306
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19470477
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17804141
66	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.17439780
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17014807
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16342594
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16021851
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.15802412
71	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15802412
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15376328
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14519142
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13228818
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12041959
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.10044370
77	ELK1_19687146_ChIP-ChIP_HELA_Human	1.08549370
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08006107
79	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07210774
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06927541
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06426800
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06011382
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05262916
84	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04081595
85	VDR_23849224_ChIP-Seq_CD4+_Human	1.01119317
86	MYC_19829295_ChIP-Seq_ESCs_Human	0.99712090
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99372031
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98387509
89	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.97535135
90	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.97458900
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97283526
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97107849
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96956562
94	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.95900894
95	ERA_21632823_ChIP-Seq_H3396_Human	0.94227684
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.93887468
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92250812
98	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.91921740
99	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.91834525
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.91681258

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	2.76116750
2	MP0002102_abnormal_ear_morphology	2.67460084
3	MP0005551_abnormal_eye_electrophysiolog	2.51412242
4	MP0003880_abnormal_central_pattern	2.38802835
5	MP0004142_abnormal_muscle_tone	2.34454702
6	MP0008877_abnormal_DNA_methylation	2.31066880
7	MP0002876_abnormal_thyroid_physiology	2.21951429
8	MP0008875_abnormal_xenobiotic_pharmacok	2.10413925
9	MP0009046_muscle_twitch	2.07502893
10	MP0001529_abnormal_vocalization	2.05273381
11	MP0002163_abnormal_gland_morphology	2.03070577
12	MP0003787_abnormal_imprinting	1.98490351
13	MP0009745_abnormal_behavioral_response	1.98243980
14	MP0006292_abnormal_olfactory_placode	1.95069840
15	MP0001968_abnormal_touch/_nociception	1.94401110
16	MP0002837_dystrophic_cardiac_calcinosis	1.93979632
17	MP0004133_heterotaxia	1.90937257
18	MP0000372_irregular_coat_pigmentation	1.90573947
19	MP0001986_abnormal_taste_sensitivity	1.89635624
20	MP0008872_abnormal_physiological_respon	1.88973253
21	MP0004742_abnormal_vestibular_system	1.85646225
22	MP0006072_abnormal_retinal_apoptosis	1.85354734
23	MP0003136_yellow_coat_color	1.85050664
24	MP0002638_abnormal_pupillary_reflex	1.83186741
25	MP0005646_abnormal_pituitary_gland	1.82639296
26	MP0003011_delayed_dark_adaptation	1.79682468
27	MP0005253_abnormal_eye_physiology	1.78668090
28	MP0000569_abnormal_digit_pigmentation	1.74773397
29	MP0008995_early_reproductive_senescence	1.73087360
30	MP0004885_abnormal_endolymph	1.69849350
31	MP0005083_abnormal_biliary_tract	1.68746884
32	MP0005645_abnormal_hypothalamus_physiol	1.66551230
33	MP0004147_increased_porphyrin_level	1.66386754
34	MP0001905_abnormal_dopamine_level	1.65868593
35	MP0004043_abnormal_pH_regulation	1.65196879
36	MP0003646_muscle_fatigue	1.62762511
37	MP0006276_abnormal_autonomic_nervous	1.61277866
38	MP0001501_abnormal_sleep_pattern	1.59597772
39	MP0005379_endocrine/exocrine_gland_phen	1.58806991
40	MP0001502_abnormal_circadian_rhythm	1.56504990
41	MP0002272_abnormal_nervous_system	1.54095046
42	MP0004145_abnormal_muscle_electrophysio	1.47896102
43	MP0001485_abnormal_pinna_reflex	1.44335793
44	MP0002736_abnormal_nociception_after	1.42025610
45	MP0002064_seizures	1.40644217
46	MP0000631_abnormal_neuroendocrine_gland	1.39791770
47	MP0002938_white_spotting	1.38976063
48	MP0005167_abnormal_blood-brain_barrier	1.38295904
49	MP0005365_abnormal_bile_salt	1.34639419
50	MP0002572_abnormal_emotion/affect_behav	1.26907130
51	MP0001486_abnormal_startle_reflex	1.26254303
52	MP0010386_abnormal_urinary_bladder	1.25744053
53	MP0005174_abnormal_tail_pigmentation	1.22326171
54	MP0002557_abnormal_social/conspecific_i	1.22058981
55	MP0002067_abnormal_sensory_capabilities	1.18737222
56	MP0001984_abnormal_olfaction	1.18143030
57	MP0005171_absent_coat_pigmentation	1.17470209
58	MP0005084_abnormal_gallbladder_morpholo	1.16793999
59	MP0002160_abnormal_reproductive_system	1.14983154
60	MP0002653_abnormal_ependyma_morphology	1.13807296
61	MP0000230_abnormal_systemic_arterial	1.12488633
62	MP0005085_abnormal_gallbladder_physiolo	1.12015911
63	MP0002735_abnormal_chemical_nociception	1.11236503
64	MP0000427_abnormal_hair_cycle	1.10409231
65	MP0000026_abnormal_inner_ear	1.09906692
66	MP0002277_abnormal_respiratory_mucosa	1.09806045
67	MP0001970_abnormal_pain_threshold	1.09128500
68	MP0002095_abnormal_skin_pigmentation	1.08764755
69	MP0003283_abnormal_digestive_organ	1.07696605
70	MP0008961_abnormal_basal_metabolism	1.05341828
71	MP0002733_abnormal_thermal_nociception	1.02633218
72	MP0003252_abnormal_bile_duct	1.02500979
73	MP0005386_behavior/neurological_phenoty	1.01881091
74	MP0004924_abnormal_behavior	1.01881091
75	MP0000778_abnormal_nervous_system	1.00234842
76	MP0010329_abnormal_lipoprotein_level	0.97219854
77	MP0002909_abnormal_adrenal_gland	0.95701254
78	MP0002063_abnormal_learning/memory/cond	0.94232770
79	MP0003122_maternal_imprinting	0.94164780
80	MP0008775_abnormal_heart_ventricle	0.93934548
81	MP0005195_abnormal_posterior_eye	0.92882884
82	MP0005389_reproductive_system_phenotype	0.92146568
83	MP0003121_genomic_imprinting	0.89998177
84	MP0002752_abnormal_somatic_nervous	0.89260985
85	MP0002928_abnormal_bile_duct	0.89147741
86	MP0002229_neurodegeneration	0.87904989
87	MP0008789_abnormal_olfactory_epithelium	0.87801312
88	MP0003718_maternal_effect	0.86642840
89	MP0009379_abnormal_foot_pigmentation	0.83542103
90	MP0003635_abnormal_synaptic_transmissio	0.82075594
91	MP0001324_abnormal_eye_pigmentation	0.81991989
92	MP0003938_abnormal_ear_development	0.79805111
93	MP0001963_abnormal_hearing_physiology	0.79437028
94	MP0008058_abnormal_DNA_repair	0.78474800
95	MP0005448_abnormal_energy_balance	0.78300733
96	MP0002234_abnormal_pharynx_morphology	0.77773454
97	MP0002734_abnormal_mechanical_nocicepti	0.77403654
98	MP0002184_abnormal_innervation	0.77221607
99	MP0002693_abnormal_pancreas_physiology	0.77032629
100	MP0002751_abnormal_autonomic_nervous	0.73273241

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.24400293
2	Pancreatic cysts (HP:0001737)	4.21321120
3	Molar tooth sign on MRI (HP:0002419)	4.18625550
4	Abnormality of midbrain morphology (HP:0002418)	4.18625550
5	Pancreatic fibrosis (HP:0100732)	3.98772377
6	True hermaphroditism (HP:0010459)	3.63775036
7	Type II lissencephaly (HP:0007260)	3.57808409
8	Nephronophthisis (HP:0000090)	3.42412137
9	Medial flaring of the eyebrow (HP:0010747)	3.21133766
10	Abnormality of the renal medulla (HP:0100957)	3.16842799
11	Abnormality of the renal cortex (HP:0011035)	3.14303079
12	Lipid accumulation in hepatocytes (HP:0006561)	3.02476013
13	Mitochondrial inheritance (HP:0001427)	3.02138611
14	Increased hepatocellular lipid droplets (HP:0006565)	3.00810686
15	Pendular nystagmus (HP:0012043)	2.87778622
16	Abnormal number of erythroid precursors (HP:0012131)	2.87715527
17	Hyperventilation (HP:0002883)	2.85826256
18	Increased CSF lactate (HP:0002490)	2.85170296
19	Increased corneal curvature (HP:0100692)	2.75130719
20	Keratoconus (HP:0000563)	2.75130719
21	Attenuation of retinal blood vessels (HP:0007843)	2.74037528
22	Abolished electroretinogram (ERG) (HP:0000550)	2.73830711
23	Inability to walk (HP:0002540)	2.71338063
24	Gait imbalance (HP:0002141)	2.63381169
25	Acute necrotizing encephalopathy (HP:0006965)	2.62932821
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.56122585
27	Congenital primary aphakia (HP:0007707)	2.56060889
28	Hepatocellular necrosis (HP:0001404)	2.52964130
29	Large for gestational age (HP:0001520)	2.51605481
30	Cystic liver disease (HP:0006706)	2.50714836
31	Abnormality of cells of the erythroid lineage (HP:0012130)	2.50701354
32	Abnormal drinking behavior (HP:0030082)	2.40568545
33	Polydipsia (HP:0001959)	2.40568545
34	Renal Fanconi syndrome (HP:0001994)	2.39374502
35	Chronic hepatic failure (HP:0100626)	2.38104014
36	Hepatic necrosis (HP:0002605)	2.36591325
37	Decreased central vision (HP:0007663)	2.36016477
38	Hypothermia (HP:0002045)	2.35327076
39	Tubular atrophy (HP:0000092)	2.33488920
40	Acute encephalopathy (HP:0006846)	2.33212081
41	Progressive macrocephaly (HP:0004481)	2.32124859
42	Concave nail (HP:0001598)	2.31459590
43	3-Methylglutaconic aciduria (HP:0003535)	2.31045363
44	Hyperalaninemia (HP:0003348)	2.30393101
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.30393101
46	Abnormality of alanine metabolism (HP:0010916)	2.30393101
47	Lissencephaly (HP:0001339)	2.30041449
48	Colon cancer (HP:0003003)	2.29134927
49	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.28535134
50	Optic disc pallor (HP:0000543)	2.27465249
51	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.27230150
52	Progressive inability to walk (HP:0002505)	2.26029534
53	Congenital hepatic fibrosis (HP:0002612)	2.24966777
54	Sclerocornea (HP:0000647)	2.24945542
55	Renal cortical cysts (HP:0000803)	2.24303394
56	Exertional dyspnea (HP:0002875)	2.24005115
57	Abnormal biliary tract physiology (HP:0012439)	2.23369628
58	Bile duct proliferation (HP:0001408)	2.23369628
59	Polyuria (HP:0000103)	2.22392916
60	Genital tract atresia (HP:0001827)	2.20122342
61	Nephrogenic diabetes insipidus (HP:0009806)	2.20007662
62	Neoplasm of the adrenal cortex (HP:0100641)	2.18277758
63	Anencephaly (HP:0002323)	2.15077040
64	Vaginal atresia (HP:0000148)	2.14020894
65	Abnormal mitochondria in muscle tissue (HP:0008316)	2.13402489
66	Retinal dysplasia (HP:0007973)	2.12857560
67	Cerebellar dysplasia (HP:0007033)	2.06723775
68	Congenital, generalized hypertrichosis (HP:0004540)	2.06187950
69	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.04899266
70	Absent speech (HP:0001344)	2.04712390
71	Chorioretinal atrophy (HP:0000533)	2.04011387
72	Optic nerve hypoplasia (HP:0000609)	2.00907320
73	Short tibia (HP:0005736)	1.97674466
74	Furrowed tongue (HP:0000221)	1.95382233
75	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95078444
76	Anterior segment dysgenesis (HP:0007700)	1.94798125
77	Gaze-evoked nystagmus (HP:0000640)	1.92262042
78	Broad-based gait (HP:0002136)	1.91554189
79	Abnormality of the labia minora (HP:0012880)	1.90861069
80	Increased serum lactate (HP:0002151)	1.89164615
81	Congenital sensorineural hearing impairment (HP:0008527)	1.88605342
82	Postaxial foot polydactyly (HP:0001830)	1.88156201
83	Stomach cancer (HP:0012126)	1.87348681
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.85983387
85	Poor coordination (HP:0002370)	1.85580685
86	Severe muscular hypotonia (HP:0006829)	1.84376730
87	Pachygyria (HP:0001302)	1.82891209
88	Abnormality of urine glucose concentration (HP:0011016)	1.82472817
89	Glycosuria (HP:0003076)	1.82472817
90	Increased intramyocellular lipid droplets (HP:0012240)	1.81726474
91	Male pseudohermaphroditism (HP:0000037)	1.79577002
92	Abnormal urine output (HP:0012590)	1.79301030
93	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.79175614
94	Progressive cerebellar ataxia (HP:0002073)	1.79048891
95	Limb dystonia (HP:0002451)	1.78514470
96	Fair hair (HP:0002286)	1.76317739
97	Protruding tongue (HP:0010808)	1.75788865
98	Hypomagnesemia (HP:0002917)	1.74398297
99	Progressive microcephaly (HP:0000253)	1.73571454
100	Postaxial hand polydactyly (HP:0001162)	1.73470000

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.19405430
2	ADRBK2	3.76648405
3	MAP4K2	3.33149072
4	TLK1	3.15301083
5	CAMKK2	3.02689168
6	GRK1	2.69304179
7	WNK3	2.53687802
8	BMPR1B	2.39058796
9	WNK4	2.38363247
10	ZAK	2.19863002
11	NEK2	2.16871585
12	NUAK1	2.06068070
13	TAOK3	2.03343048
14	MAP3K4	1.89706498
15	PINK1	1.80005217
16	CASK	1.79560017
17	MAPK13	1.72915702
18	ACVR1B	1.68772378
19	TRIM28	1.61270390
20	DAPK2	1.59159470
21	PAK3	1.59114373
22	OXSR1	1.51338597
23	MAP2K6	1.43847393
24	DYRK2	1.34543708
25	INSRR	1.32537419
26	NTRK3	1.32348497
27	TXK	1.32116422
28	ADRBK1	1.31000019
29	BCKDK	1.30345101
30	CCNB1	1.26036975
31	MARK1	1.25853103
32	EPHA4	1.23909221
33	MAP2K7	1.17286744
34	VRK2	1.07688893
35	VRK1	1.02804196
36	TGFBR1	1.00953241
37	CDK19	0.97618907
38	SIK2	0.91471140
39	PRKCE	0.91343648
40	PRKCG	0.89753560
41	MKNK2	0.89325346
42	ERBB3	0.89068181
43	CSNK1G1	0.86806011
44	STK39	0.86519613
45	STK16	0.85727197
46	PIK3CA	0.85515986
47	CSNK1G2	0.84926240
48	BCR	0.84807933
49	MAPK15	0.84311355
50	TIE1	0.83626006
51	CAMK1	0.81089033
52	TNIK	0.79174383
53	CSNK1G3	0.76274612
54	PTK2B	0.76199047
55	NME1	0.76014665
56	CHUK	0.75961890
57	FGFR2	0.73702269
58	PHKG2	0.72865013
59	PHKG1	0.72865013
60	CAMKK1	0.71767555
61	NTRK2	0.67840669
62	RPS6KA5	0.66101013
63	MAP3K7	0.64704763
64	CAMK1D	0.62146419
65	IKBKB	0.59242729
66	CSNK1A1L	0.58345285
67	STK11	0.58081778
68	MAPKAPK5	0.57292112
69	PKN1	0.57283031
70	STK38L	0.57134812
71	KIT	0.53774386
72	CAMK2A	0.51993919
73	TAF1	0.49540837
74	TNK2	0.49519266
75	PRKAA2	0.48866769
76	CAMK4	0.48648627
77	PRKACA	0.48217994
78	PRKCI	0.48144071
79	LIMK1	0.46405692
80	PLK2	0.46324722
81	PNCK	0.42464133
82	GRK7	0.41939962
83	PRKCQ	0.41639203
84	PRKCZ	0.41078352
85	OBSCN	0.40714073
86	MAP2K4	0.38656524
87	MUSK	0.38591975
88	ABL2	0.37936809
89	EPHB2	0.37609992
90	PLK3	0.36694574
91	PAK6	0.36326005
92	PLK4	0.36269872
93	NLK	0.35423101
94	FLT3	0.34661126
95	PRKACB	0.34546873
96	PRKCA	0.33180447
97	CSNK1A1	0.32423082
98	MKNK1	0.30887353
99	TEC	0.30251524
100	GRK5	0.29837540

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.37377424
2	Phototransduction_Homo sapiens_hsa04744	2.89200939
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.69068441
4	Parkinsons disease_Homo sapiens_hsa05012	2.66849755
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.63664656
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.49104508
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.23414188
8	Protein export_Homo sapiens_hsa03060	2.21111996
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.20842183
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.16254262
11	Ribosome_Homo sapiens_hsa03010	2.16180584
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.10965213
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.10486140
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.07300465
15	Nicotine addiction_Homo sapiens_hsa05033	1.98201852
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.97906342
17	Butanoate metabolism_Homo sapiens_hsa00650	1.94563773
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.87983096
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.85328952
20	Huntingtons disease_Homo sapiens_hsa05016	1.68665090
21	Alzheimers disease_Homo sapiens_hsa05010	1.63990276
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.59600546
23	RNA polymerase_Homo sapiens_hsa03020	1.56839742
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.54591047
25	Basal transcription factors_Homo sapiens_hsa03022	1.54439144
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.51999858
27	Homologous recombination_Homo sapiens_hsa03440	1.46529276
28	Peroxisome_Homo sapiens_hsa04146	1.41717061
29	Caffeine metabolism_Homo sapiens_hsa00232	1.39762960
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.38229307
31	Asthma_Homo sapiens_hsa05310	1.34878544
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.32843746
33	Regulation of autophagy_Homo sapiens_hsa04140	1.27849840
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.26916023
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.26611692
36	Propanoate metabolism_Homo sapiens_hsa00640	1.14634038
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13643498
38	Olfactory transduction_Homo sapiens_hsa04740	1.08741994
39	One carbon pool by folate_Homo sapiens_hsa00670	1.07772189
40	Taste transduction_Homo sapiens_hsa04742	1.07345036
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04043447
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03559930
43	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00480782
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00412421
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96165223
46	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93835549
47	Morphine addiction_Homo sapiens_hsa05032	0.93707089
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.91167009
49	Sulfur metabolism_Homo sapiens_hsa00920	0.90243720
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.90182211
51	Mineral absorption_Homo sapiens_hsa04978	0.86820066
52	ABC transporters_Homo sapiens_hsa02010	0.86649613
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.79294029
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78600804
55	GABAergic synapse_Homo sapiens_hsa04727	0.78046446
56	Proteasome_Homo sapiens_hsa03050	0.77702732
57	RNA degradation_Homo sapiens_hsa03018	0.75573154
58	Retinol metabolism_Homo sapiens_hsa00830	0.73165677
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72926204
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.72657222
61	Serotonergic synapse_Homo sapiens_hsa04726	0.72279051
62	Allograft rejection_Homo sapiens_hsa05330	0.71255844
63	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.70145727
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.69763965
65	Insulin secretion_Homo sapiens_hsa04911	0.69546635
66	Metabolic pathways_Homo sapiens_hsa01100	0.69399553
67	Histidine metabolism_Homo sapiens_hsa00340	0.68265910
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67554157
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.67243713
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.66268795
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63183620
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.62099319
73	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61391702
74	Purine metabolism_Homo sapiens_hsa00230	0.59444526
75	Cocaine addiction_Homo sapiens_hsa05030	0.59300597
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59289075
77	Circadian entrainment_Homo sapiens_hsa04713	0.57631703
78	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.56083010
79	Graft-versus-host disease_Homo sapiens_hsa05332	0.53415453
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52640858
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52538627
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50740906
83	Fatty acid elongation_Homo sapiens_hsa00062	0.48990363
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46922673
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46154860
86	Circadian rhythm_Homo sapiens_hsa04710	0.45839788
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.44684340
88	Folate biosynthesis_Homo sapiens_hsa00790	0.44372111
89	Sulfur relay system_Homo sapiens_hsa04122	0.43578395
90	Nucleotide excision repair_Homo sapiens_hsa03420	0.41680937
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37558275
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37453976
93	Calcium signaling pathway_Homo sapiens_hsa04020	0.36801221
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35727209
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.34249691
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.31027766
97	Salivary secretion_Homo sapiens_hsa04970	0.30947767
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.27432891
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.26574205
100	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24964665

FTLP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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