ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	6.46208098
2	heme transport (GO:0015886)	5.69071098
3	regulation of cilium movement (GO:0003352)	4.96838021
4	glyoxylate metabolic process (GO:0046487)	4.85277404
5	high-density lipoprotein particle remodeling (GO:0034375)	4.63716551
6	histone H2A acetylation (GO:0043968)	4.41970890
7	vitamin biosynthetic process (GO:0009110)	4.38597939
8	artery smooth muscle contraction (GO:0014824)	4.31691494
9	reverse cholesterol transport (GO:0043691)	4.29167236
10	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.26443538
11	cell wall macromolecule catabolic process (GO:0016998)	4.13654246
12	short-chain fatty acid metabolic process (GO:0046459)	4.09914503
13	phospholipid efflux (GO:0033700)	4.01987763
14	protein-lipid complex remodeling (GO:0034368)	3.94697163
15	macromolecular complex remodeling (GO:0034367)	3.94697163
16	plasma lipoprotein particle remodeling (GO:0034369)	3.94697163
17	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.86864558
18	iron coordination entity transport (GO:1901678)	3.86442183
19	low-density lipoprotein particle remodeling (GO:0034374)	3.80344221
20	behavioral response to ethanol (GO:0048149)	3.75513533
21	cellular response to leptin stimulus (GO:0044320)	3.70875826
22	regulation of acrosome reaction (GO:0060046)	3.66995190
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.60814977
24	tonic smooth muscle contraction (GO:0014820)	3.60037566
25	negative regulation of cAMP-mediated signaling (GO:0043951)	3.56298037
26	phospholipid homeostasis (GO:0055091)	3.51150364
27	epoxygenase P450 pathway (GO:0019373)	3.46991411
28	cell wall macromolecule metabolic process (GO:0044036)	3.43987222
29	plasma lipoprotein particle assembly (GO:0034377)	3.41932825
30	exogenous drug catabolic process (GO:0042738)	3.41286441
31	vascular smooth muscle contraction (GO:0014829)	3.39852503
32	tryptophan metabolic process (GO:0006568)	3.37748502
33	cellular ketone body metabolic process (GO:0046950)	3.35586915
34	negative regulation of fibrinolysis (GO:0051918)	3.31739136
35	regulation of protein glycosylation (GO:0060049)	3.30444725
36	regulation of fibrinolysis (GO:0051917)	3.29074282
37	indolalkylamine metabolic process (GO:0006586)	3.26704428
38	plasma lipoprotein particle organization (GO:0071827)	3.25341006
39	cholesterol efflux (GO:0033344)	3.20533253
40	regulation of cholesterol esterification (GO:0010872)	3.19535537
41	regulation of glucokinase activity (GO:0033131)	3.18216117
42	regulation of hexokinase activity (GO:1903299)	3.18216117
43	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.16898094
44	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.16898094
45	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.16299971
46	triglyceride homeostasis (GO:0070328)	3.13484883
47	acylglycerol homeostasis (GO:0055090)	3.13484883
48	branched-chain amino acid catabolic process (GO:0009083)	3.13213297
49	intestinal cholesterol absorption (GO:0030299)	3.12776812
50	regulation of microtubule-based movement (GO:0060632)	3.11922049
51	tryptophan catabolic process (GO:0006569)	3.11533175
52	indole-containing compound catabolic process (GO:0042436)	3.11533175
53	indolalkylamine catabolic process (GO:0046218)	3.11533175
54	aldehyde catabolic process (GO:0046185)	3.06115276
55	nonmotile primary cilium assembly (GO:0035058)	3.05231499
56	opioid receptor signaling pathway (GO:0038003)	3.03012252
57	omega-hydroxylase P450 pathway (GO:0097267)	3.01259127
58	drug catabolic process (GO:0042737)	2.97538957
59	plasma lipoprotein particle clearance (GO:0034381)	2.96932184
60	lysine catabolic process (GO:0006554)	2.96041017
61	lysine metabolic process (GO:0006553)	2.96041017
62	photoreceptor cell maintenance (GO:0045494)	2.95218378
63	bile acid biosynthetic process (GO:0006699)	2.91926265
64	aromatic amino acid family catabolic process (GO:0009074)	2.90372230
65	ketone body metabolic process (GO:1902224)	2.88573372
66	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.87992758
67	protein-lipid complex subunit organization (GO:0071825)	2.87654863
68	response to leptin (GO:0044321)	2.87354653
69	sulfation (GO:0051923)	2.87268576
70	adaptation of signaling pathway (GO:0023058)	2.85764561
71	response to pheromone (GO:0019236)	2.85304914
72	negative regulation of appetite (GO:0032099)	2.84651109
73	negative regulation of response to food (GO:0032096)	2.84651109
74	very-low-density lipoprotein particle assembly (GO:0034379)	2.81571095
75	urate metabolic process (GO:0046415)	2.81330862
76	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.80098019
77	GMP metabolic process (GO:0046037)	2.79329765
78	regulation of protein activation cascade (GO:2000257)	2.78837099
79	brain morphogenesis (GO:0048854)	2.77534078
80	L-ascorbic acid metabolic process (GO:0019852)	2.75375514
81	quinone biosynthetic process (GO:1901663)	2.74344073
82	cofactor transport (GO:0051181)	2.73766993
83	branched-chain amino acid metabolic process (GO:0009081)	2.72583351
84	protein-lipid complex assembly (GO:0065005)	2.70998028
85	DNA deamination (GO:0045006)	2.70833652
86	oxidative demethylation (GO:0070989)	2.67509701
87	adult feeding behavior (GO:0008343)	2.67361488
88	alpha-amino acid catabolic process (GO:1901606)	2.67355008
89	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.66566167
90	L-phenylalanine catabolic process (GO:0006559)	2.66566167
91	monocarboxylic acid catabolic process (GO:0072329)	2.64449779
92	uronic acid metabolic process (GO:0006063)	2.62702952
93	glucuronate metabolic process (GO:0019585)	2.62702952
94	aspartate family amino acid catabolic process (GO:0009068)	2.61793585
95	prenylation (GO:0097354)	2.60968907
96	protein prenylation (GO:0018342)	2.60968907
97	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.57657158
98	interleukin-1-mediated signaling pathway (GO:0070498)	2.56366024
99	sphingoid metabolic process (GO:0046519)	2.55817864
100	regulation of complement activation (GO:0030449)	2.54400659

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.08557861
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.70467330
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.46069378
4	VDR_22108803_ChIP-Seq_LS180_Human	3.32218359
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.18313127
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.87722553
7	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.75463596
8	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.56898332
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.51622151
10	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.39637946
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.27781447
12	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.24574084
13	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.17107722
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.07152814
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.99765038
16	IRF1_19129219_ChIP-ChIP_H3396_Human	1.98448292
17	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.95734695
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.88681133
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88014509
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.73456823
21	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.69883850
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66890051
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.66890051
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.66124329
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.66080545
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.65480363
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.64446410
28	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.63761538
29	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.59960717
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.56777133
31	NANOG_19829295_ChIP-Seq_ESCs_Human	1.56320069
32	SOX2_19829295_ChIP-Seq_ESCs_Human	1.56320069
33	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.51105657
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48695664
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.48624647
36	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.47632464
37	P300_19829295_ChIP-Seq_ESCs_Human	1.45026328
38	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.43775900
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41909695
40	FUS_26573619_Chip-Seq_HEK293_Human	1.41622321
41	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.40246193
42	TCF4_23295773_ChIP-Seq_U87_Human	1.38457399
43	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.36426613
44	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.34786322
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34593952
46	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.34554043
47	TP53_16413492_ChIP-PET_HCT116_Human	1.34353741
48	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.32758692
49	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.28183926
50	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.28181055
51	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26465171
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.23363154
53	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.22842217
54	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.22409032
55	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.21398988
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21095317
57	HTT_18923047_ChIP-ChIP_STHdh_Human	1.20844546
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.20649331
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20649331
60	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.20109461
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.18602329
62	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17875387
63	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.16412775
64	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15493134
65	IGF1R_20145208_ChIP-Seq_DFB_Human	1.15458734
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.15082460
67	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14673961
68	CDX2_22108803_ChIP-Seq_LS180_Human	1.14632787
69	STAT3_23295773_ChIP-Seq_U87_Human	1.14500090
70	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.12591992
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12561777
72	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.09494771
73	GATA3_26560356_Chip-Seq_TH2_Human	1.07532641
74	AR_20517297_ChIP-Seq_VCAP_Human	1.07467201
75	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06669509
76	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06669509
77	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.05683334
78	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.05250927
79	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.04810573
80	EWS_26573619_Chip-Seq_HEK293_Human	1.04763031
81	P300_18555785_Chip-Seq_ESCs_Mouse	1.04092297
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03700536
83	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.02968411
84	TCF4_22108803_ChIP-Seq_LS180_Human	1.01582702
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01294159
86	CEBPB_22108803_ChIP-Seq_LS180_Human	1.01174810
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00960641
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00878688
89	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.00602437
90	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.99626084
91	AR_25329375_ChIP-Seq_VCAP_Human	0.99379712
92	ER_23166858_ChIP-Seq_MCF-7_Human	0.99313625
93	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.98743878
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98373893
95	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.98314312
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97618820
97	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97607045
98	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.97587106
99	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97353377
100	CIITA_25753668_ChIP-Seq_RAJI_Human	0.96839586

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	4.75355268
2	MP0003195_calcinosis	4.16521140
3	MP0000566_synostosis	3.29055314
4	MP0002876_abnormal_thyroid_physiology	2.99938001
5	MP0008875_abnormal_xenobiotic_pharmacok	2.88882510
6	MP0005365_abnormal_bile_salt	2.82663931
7	MP0003191_abnormal_cellular_cholesterol	2.79607339
8	MP0010329_abnormal_lipoprotein_level	2.79226306
9	MP0005085_abnormal_gallbladder_physiolo	2.70307615
10	MP0003122_maternal_imprinting	2.60015591
11	MP0005360_urolithiasis	2.59104880
12	MP0001984_abnormal_olfaction	2.50912542
13	MP0005084_abnormal_gallbladder_morpholo	2.43166845
14	MP0008789_abnormal_olfactory_epithelium	2.21034167
15	MP0005646_abnormal_pituitary_gland	2.20704304
16	MP0001666_abnormal_nutrient_absorption	2.19450915
17	MP0001968_abnormal_touch/_nociception	2.19034939
18	MP0001986_abnormal_taste_sensitivity	2.16687155
19	MP0005499_abnormal_olfactory_system	1.99659537
20	MP0005394_taste/olfaction_phenotype	1.99659537
21	MP0009278_abnormal_bone_marrow	1.85915562
22	MP0005551_abnormal_eye_electrophysiolog	1.79238495
23	MP0003045_fibrosis	1.78318681
24	MP0003806_abnormal_nucleotide_metabolis	1.68318581
25	MP0003011_delayed_dark_adaptation	1.62055891
26	MP0009780_abnormal_chondrocyte_physiolo	1.58784110
27	MP0003121_genomic_imprinting	1.51376629
28	MP0001764_abnormal_homeostasis	1.49766897
29	MP0000383_abnormal_hair_follicle	1.39586978
30	MP0001529_abnormal_vocalization	1.39325172
31	MP0002168_other_aberrant_phenotype	1.38000735
32	MP0002736_abnormal_nociception_after	1.35462151
33	MP0003183_abnormal_peptide_metabolism	1.35456947
34	MP0003868_abnormal_feces_composition	1.33509846
35	MP0002089_abnormal_postnatal_growth/wei	1.33233276
36	MP0008872_abnormal_physiological_respon	1.31134016
37	MP0005397_hematopoietic_system_phenotyp	1.30605383
38	MP0001545_abnormal_hematopoietic_system	1.30605383
39	MP0003252_abnormal_bile_duct	1.26241993
40	MP0009840_abnormal_foam_cell	1.24180169
41	MP0001501_abnormal_sleep_pattern	1.20052354
42	MP0009697_abnormal_copulation	1.18649862
43	MP0002118_abnormal_lipid_homeostasis	1.17626121
44	MP0006292_abnormal_olfactory_placode	1.15150532
45	MP0000609_abnormal_liver_physiology	1.14353457
46	MP0009764_decreased_sensitivity_to	1.13611018
47	MP0005464_abnormal_platelet_physiology	1.10279252
48	MP0005332_abnormal_amino_acid	1.07937413
49	MP0000427_abnormal_hair_cycle	1.06763381
50	MP0005645_abnormal_hypothalamus_physiol	1.06702934
51	MP0005636_abnormal_mineral_homeostasis	1.05773515
52	MP0003724_increased_susceptibility_to	1.05711809
53	MP0005167_abnormal_blood-brain_barrier	1.02140906
54	MP0003880_abnormal_central_pattern	1.01985558
55	MP0003567_abnormal_fetal_cardiomyocyte	1.01203269
56	MP0001915_intracranial_hemorrhage	1.00803049
57	MP0001486_abnormal_startle_reflex	1.00259365
58	MP0002102_abnormal_ear_morphology	0.98512811
59	MP0005395_other_phenotype	0.96720590
60	MP0005310_abnormal_salivary_gland	0.96509276
61	MP0005319_abnormal_enzyme/_coenzyme	0.92401935
62	MP0003436_decreased_susceptibility_to	0.92180138
63	MP0004782_abnormal_surfactant_physiolog	0.92013790
64	MP0001835_abnormal_antigen_presentation	0.90725624
65	MP0008877_abnormal_DNA_methylation	0.88644734
66	MP0006054_spinal_hemorrhage	0.87857290
67	MP0000598_abnormal_liver_morphology	0.87623313
68	MP0008469_abnormal_protein_level	0.84070548
69	MP0002138_abnormal_hepatobiliary_system	0.83875424
70	MP0002938_white_spotting	0.82866123
71	MP0005253_abnormal_eye_physiology	0.81820391
72	MP0010678_abnormal_skin_adnexa	0.78541084
73	MP0003172_abnormal_lysosome_physiology	0.78138873
74	MP0004019_abnormal_vitamin_homeostasis	0.77486908
75	MP0003943_abnormal_hepatobiliary_system	0.77414892
76	MP0001664_abnormal_digestion	0.77116340
77	MP0002148_abnormal_hypersensitivity_rea	0.76425782
78	MP0002733_abnormal_thermal_nociception	0.75766085
79	MP0005410_abnormal_fertilization	0.73667497
80	MP0008873_increased_physiological_sensi	0.73068348
81	MP0006035_abnormal_mitochondrial_morpho	0.72218407
82	MP0003633_abnormal_nervous_system	0.71830631
83	MP0002653_abnormal_ependyma_morphology	0.71580794
84	MP0000604_amyloidosis	0.69466518
85	MP0009642_abnormal_blood_homeostasis	0.69354891
86	MP0009333_abnormal_splenocyte_physiolog	0.69337278
87	MP0000372_irregular_coat_pigmentation	0.65228394
88	MP0003303_peritoneal_inflammation	0.65042288
89	MP0002419_abnormal_innate_immunity	0.63875993
90	MP0001970_abnormal_pain_threshold	0.63650557
91	MP0000685_abnormal_immune_system	0.62913336
92	MP0001800_abnormal_humoral_immune	0.62062831
93	MP0000631_abnormal_neuroendocrine_gland	0.60190939
94	MP0005448_abnormal_energy_balance	0.59108041
95	MP0009115_abnormal_fat_cell	0.58806208
96	MP0002078_abnormal_glucose_homeostasis	0.58456459
97	MP0003718_maternal_effect	0.57439338
98	MP0001963_abnormal_hearing_physiology	0.56301615
99	MP0002254_reproductive_system_inflammat	0.54978451
100	MP0002132_abnormal_respiratory_system	0.54462549

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intestinal atresia (HP:0011100)	6.91066210
2	Spontaneous abortion (HP:0005268)	4.28002796
3	Abnormality of the aortic arch (HP:0012303)	4.24782621
4	Broad alveolar ridges (HP:0000187)	4.00235184
5	Methylmalonic acidemia (HP:0002912)	3.98152323
6	Hyperglycinemia (HP:0002154)	3.94360026
7	Hypochromic microcytic anemia (HP:0004840)	3.94033336
8	Pancreatic islet-cell hyperplasia (HP:0004510)	3.79970344
9	Thyroid-stimulating hormone excess (HP:0002925)	3.69670307
10	Chronic hepatic failure (HP:0100626)	3.47338765
11	Deep venous thrombosis (HP:0002625)	3.36755977
12	Prolonged partial thromboplastin time (HP:0003645)	3.35483060
13	Epidermoid cyst (HP:0200040)	3.33141026
14	Hypobetalipoproteinemia (HP:0003563)	3.27565887
15	Methylmalonic aciduria (HP:0012120)	3.21512929
16	Abnormality of serine family amino acid metabolism (HP:0010894)	3.14636432
17	Abnormality of glycine metabolism (HP:0010895)	3.14636432
18	Attenuation of retinal blood vessels (HP:0007843)	2.95153846
19	Gastrointestinal atresia (HP:0002589)	2.94998550
20	Large for gestational age (HP:0001520)	2.94240305
21	Volvulus (HP:0002580)	2.90881437
22	Dicarboxylic aciduria (HP:0003215)	2.87748426
23	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.87748426
24	Gingival bleeding (HP:0000225)	2.85523721
25	Nephroblastoma (Wilms tumor) (HP:0002667)	2.80925735
26	Toxemia of pregnancy (HP:0100603)	2.76025573
27	Abnormality of vitamin B metabolism (HP:0004340)	2.75907147
28	Ketosis (HP:0001946)	2.71797086
29	Decreased central vision (HP:0007663)	2.61503558
30	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.60925048
31	Embryonal renal neoplasm (HP:0011794)	2.57378439
32	Ependymoma (HP:0002888)	2.54385099
33	Abolished electroretinogram (ERG) (HP:0000550)	2.50596000
34	Tented upper lip vermilion (HP:0010804)	2.48426918
35	Abnormality of the common coagulation pathway (HP:0010990)	2.44366535
36	Hyperglycinuria (HP:0003108)	2.38295075
37	Abnormality of endocrine pancreas physiology (HP:0012093)	2.37012504
38	Abnormality of the pancreatic islet cells (HP:0006476)	2.37012504
39	Hypochromic anemia (HP:0001931)	2.36934925
40	Rectovaginal fistula (HP:0000143)	2.36625295
41	Rectal fistula (HP:0100590)	2.36625295
42	Medial flaring of the eyebrow (HP:0010747)	2.36046165
43	Abnormality of vitamin metabolism (HP:0100508)	2.35208182
44	Joint hemorrhage (HP:0005261)	2.34984275
45	Mesangial abnormality (HP:0001966)	2.33270717
46	Abnormality of serum amino acid levels (HP:0003112)	2.25163454
47	Stomach cancer (HP:0012126)	2.24759793
48	3-Methylglutaconic aciduria (HP:0003535)	2.23098832
49	Vaginal fistula (HP:0004320)	2.22139138
50	Neoplasm of the liver (HP:0002896)	2.21894207
51	Agnosia (HP:0010524)	2.16645778
52	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.15936429
53	Amaurosis fugax (HP:0100576)	2.15073800
54	Abnormal biliary tract physiology (HP:0012439)	2.14209001
55	Bile duct proliferation (HP:0001408)	2.14209001
56	Hypolipoproteinemia (HP:0010981)	2.07250721
57	Reduced antithrombin III activity (HP:0001976)	2.02908387
58	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.99343951
59	Hypothermia (HP:0002045)	1.99080648
60	Intrahepatic cholestasis (HP:0001406)	1.97359634
61	Congenital primary aphakia (HP:0007707)	1.96576661
62	Hyperammonemia (HP:0001987)	1.94318801
63	Metabolic acidosis (HP:0001942)	1.92746018
64	Stomatitis (HP:0010280)	1.92490166
65	Biliary tract neoplasm (HP:0100574)	1.91477875
66	Abnormality of the renal cortex (HP:0011035)	1.89463315
67	Proximal tubulopathy (HP:0000114)	1.89269250
68	Intestinal fistula (HP:0100819)	1.89074151
69	Gait imbalance (HP:0002141)	1.87489592
70	Flared iliac wings (HP:0002869)	1.87321171
71	Episodic fever (HP:0001954)	1.86512367
72	Fat malabsorption (HP:0002630)	1.86059718
73	Thyroiditis (HP:0100646)	1.83121437
74	Thrombophlebitis (HP:0004418)	1.82731224
75	Pancreatic cysts (HP:0001737)	1.81202194
76	Bony spicule pigmentary retinopathy (HP:0007737)	1.80516680
77	Beaking of vertebral bodies (HP:0004568)	1.80341219
78	Pendular nystagmus (HP:0012043)	1.80140866
79	Nephronophthisis (HP:0000090)	1.78805306
80	Astrocytoma (HP:0009592)	1.77623202
81	Abnormality of the astrocytes (HP:0100707)	1.77623202
82	Vacuolated lymphocytes (HP:0001922)	1.73848170
83	Myositis (HP:0100614)	1.72981525
84	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.72932329
85	Nephrogenic diabetes insipidus (HP:0009806)	1.72697551
86	Cerebellar dysplasia (HP:0007033)	1.72513970
87	Orchitis (HP:0100796)	1.70930021
88	Amyloidosis (HP:0011034)	1.69935354
89	Retinitis pigmentosa (HP:0000510)	1.67236762
90	Glycosuria (HP:0003076)	1.66929199
91	Abnormality of urine glucose concentration (HP:0011016)	1.66929199
92	Rhabdomyosarcoma (HP:0002859)	1.66914549
93	Spastic paraparesis (HP:0002313)	1.66237726
94	Complement deficiency (HP:0004431)	1.66044027
95	Renal cortical cysts (HP:0000803)	1.65396274
96	Abnormality of methionine metabolism (HP:0010901)	1.61766715
97	Arterial thrombosis (HP:0004420)	1.61031972
98	Severe visual impairment (HP:0001141)	1.60927727
99	Status epilepticus (HP:0002133)	1.59935776
100	Abnormality of the alveolar ridges (HP:0006477)	1.59715407

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	6.84571686
2	FRK	4.65975361
3	ADRBK2	4.01041105
4	BMPR1B	3.26249991
5	ACVR1B	2.78724804
6	MAP4K2	2.66677872
7	NUAK1	2.62693930
8	BCKDK	2.50725750
9	TAOK3	2.30614662
10	ERN1	2.15955283
11	IRAK1	2.01418748
12	GRK1	1.86372037
13	VRK2	1.80047146
14	ZAK	1.71217223
15	KIT	1.61728747
16	PDK2	1.54595415
17	PIM2	1.52674205
18	CSF1R	1.48039043
19	FGFR2	1.34825751
20	MAP4K1	1.23543191
21	MST4	1.22365911
22	VRK1	1.19903809
23	PINK1	1.18217928
24	NTRK3	1.12494172
25	CHUK	1.10526108
26	TNK2	1.04452048
27	FGR	1.02193322
28	TEC	1.01385678
29	DAPK2	0.97972929
30	ADRBK1	0.95380050
31	SYK	0.95142349
32	OXSR1	0.94504387
33	ITK	0.93643342
34	IKBKB	0.92822881
35	FGFR4	0.91799899
36	PRKCQ	0.91448726
37	PRKCE	0.89603585
38	EIF2AK3	0.89291130
39	PTK2B	0.87736434
40	RPS6KA5	0.87258513
41	FLT3	0.85263817
42	PRKCG	0.84284108
43	FGFR3	0.81701116
44	MAP3K5	0.81340849
45	MAPK13	0.81097094
46	PLK2	0.79903528
47	TGFBR1	0.78816263
48	PDK1	0.74766534
49	LYN	0.68903991
50	MAP2K1	0.68083023
51	PIK3CA	0.67766704
52	PIK3CG	0.66092288
53	ERBB3	0.63586581
54	PRKCI	0.63502910
55	ABL1	0.59936458
56	MAP2K2	0.57847448
57	PRKCZ	0.57781217
58	GRK5	0.53198879
59	TXK	0.52196852
60	INSRR	0.51279718
61	BTK	0.50984594
62	MELK	0.47950331
63	PIM1	0.47914184
64	TRIM28	0.46950952
65	TBK1	0.46326604
66	IGF1R	0.44789284
67	PKN2	0.44019738
68	BLK	0.43655971
69	HCK	0.42978622
70	FES	0.41721374
71	GRK6	0.41326365
72	WEE1	0.40705591
73	JAK2	0.40594835
74	MAPK3	0.39994082
75	EPHA4	0.39827643
76	TLK1	0.37628498
77	MAP3K2	0.37354162
78	STK4	0.36906533
79	BCR	0.36618383
80	BRSK2	0.36266948
81	KDR	0.35826062
82	STK3	0.34998245
83	CSNK1G1	0.34910732
84	IRAK4	0.34556585
85	PDPK1	0.33303574
86	SGK2	0.33203270
87	CAMK4	0.33022392
88	MAP2K6	0.32624521
89	CAMKK2	0.32539802
90	WNK3	0.31777603
91	NME1	0.31545220
92	FGFR1	0.31339683
93	PRKD3	0.30982730
94	PRKAA2	0.30967584
95	SRPK1	0.30691365
96	PRKACB	0.30521076
97	BMPR2	0.30489206
98	MATK	0.30277360
99	MAPK11	0.28943592
100	IKBKE	0.28847715

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.00707635
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.95220541
3	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.68973681
4	Complement and coagulation cascades_Homo sapiens_hsa04610	2.61794586
5	Caffeine metabolism_Homo sapiens_hsa00232	2.49473201
6	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.43450619
7	Fatty acid degradation_Homo sapiens_hsa00071	2.42743681
8	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.34450412
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.30846897
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25841227
11	Propanoate metabolism_Homo sapiens_hsa00640	2.18074373
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.14378004
13	Asthma_Homo sapiens_hsa05310	2.05169182
14	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.04864481
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.97116005
16	Retinol metabolism_Homo sapiens_hsa00830	1.96994671
17	Chemical carcinogenesis_Homo sapiens_hsa05204	1.96553952
18	Allograft rejection_Homo sapiens_hsa05330	1.88346678
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.84544161
20	Peroxisome_Homo sapiens_hsa04146	1.83608601
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83391136
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.81172652
23	ABC transporters_Homo sapiens_hsa02010	1.77494444
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.72663704
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.72300993
26	Fat digestion and absorption_Homo sapiens_hsa04975	1.71375800
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.70809257
28	Fatty acid metabolism_Homo sapiens_hsa01212	1.68670881
29	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.62577811
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.61623874
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.55555292
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.49410909
33	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.49200713
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.47751073
35	PPAR signaling pathway_Homo sapiens_hsa03320	1.45362661
36	One carbon pool by folate_Homo sapiens_hsa00670	1.44141644
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.42157576
38	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.33648571
39	Glycerolipid metabolism_Homo sapiens_hsa00561	1.32873278
40	Histidine metabolism_Homo sapiens_hsa00340	1.32052528
41	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.28206586
42	beta-Alanine metabolism_Homo sapiens_hsa00410	1.20623157
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.18084384
44	Arginine biosynthesis_Homo sapiens_hsa00220	1.15789515
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.13919062
46	Fatty acid elongation_Homo sapiens_hsa00062	1.11053416
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.10529310
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.09361753
49	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.05774795
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.04264661
51	Ether lipid metabolism_Homo sapiens_hsa00565	1.03534788
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.96241114
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.92538447
54	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.88527877
55	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.86178147
56	Phototransduction_Homo sapiens_hsa04744	0.85633892
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.83659305
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78857644
59	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.76442028
60	Leishmaniasis_Homo sapiens_hsa05140	0.69285579
61	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.66650149
62	Protein export_Homo sapiens_hsa03060	0.65635260
63	African trypanosomiasis_Homo sapiens_hsa05143	0.65581787
64	Other glycan degradation_Homo sapiens_hsa00511	0.64157516
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.62695958
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61232784
67	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.60998431
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58928788
69	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.58318594
70	Metabolic pathways_Homo sapiens_hsa01100	0.57603740
71	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56988950
72	Glutathione metabolism_Homo sapiens_hsa00480	0.55914931
73	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.51800047
74	Primary immunodeficiency_Homo sapiens_hsa05340	0.51788811
75	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51400443
76	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49253544
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.49066095
78	Lysine degradation_Homo sapiens_hsa00310	0.46984684
79	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.46320920
80	Regulation of autophagy_Homo sapiens_hsa04140	0.45786929
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.44611929
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42380202
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41785362
84	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.39475609
85	Carbon metabolism_Homo sapiens_hsa01200	0.39162884
86	Tuberculosis_Homo sapiens_hsa05152	0.37247633
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.36899553
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.36222684
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34690975
90	Olfactory transduction_Homo sapiens_hsa04740	0.34362257
91	Bile secretion_Homo sapiens_hsa04976	0.26572737
92	Herpes simplex infection_Homo sapiens_hsa05168	0.25524595
93	Renin-angiotensin system_Homo sapiens_hsa04614	0.23405063
94	Viral myocarditis_Homo sapiens_hsa05416	0.22385177
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.21860931
96	Legionellosis_Homo sapiens_hsa05134	0.21407033
97	Lysosome_Homo sapiens_hsa04142	0.20949922
98	Renin secretion_Homo sapiens_hsa04924	0.16627374
99	Glucagon signaling pathway_Homo sapiens_hsa04922	0.16594081
100	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.16238614

FTOP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »