Rank | Gene Set | Z-score |
---|---|---|
1 | DNA deamination (GO:0045006) | 5.02929852 |
2 | ribosome assembly (GO:0042255) | 4.99582076 |
3 | establishment of integrated proviral latency (GO:0075713) | 4.96249216 |
4 | ribosomal small subunit assembly (GO:0000028) | 4.71774152 |
5 | establishment of viral latency (GO:0019043) | 4.63080350 |
6 | proteasome assembly (GO:0043248) | 4.61995776 |
7 | protein maturation by protein folding (GO:0022417) | 4.58220952 |
8 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.47274559 |
9 | rRNA modification (GO:0000154) | 4.30328008 |
10 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.26747892 |
11 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.20770623 |
12 | pseudouridine synthesis (GO:0001522) | 4.20397244 |
13 | termination of RNA polymerase III transcription (GO:0006386) | 4.16404016 |
14 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.16404016 |
15 | Golgi transport vesicle coating (GO:0048200) | 4.15804195 |
16 | COPI coating of Golgi vesicle (GO:0048205) | 4.15804195 |
17 | formation of translation preinitiation complex (GO:0001731) | 4.10057550 |
18 | DNA strand elongation (GO:0022616) | 4.09399979 |
19 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 4.03982813 |
20 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.03529832 |
21 | nucleobase biosynthetic process (GO:0046112) | 4.02217028 |
22 | telomere maintenance via recombination (GO:0000722) | 3.98983283 |
23 | cullin deneddylation (GO:0010388) | 3.98184538 |
24 | maturation of SSU-rRNA (GO:0030490) | 3.93380946 |
25 | protein deneddylation (GO:0000338) | 3.87056152 |
26 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.85563367 |
27 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.81993890 |
28 | purine nucleobase biosynthetic process (GO:0009113) | 3.81234404 |
29 | regulation of mitochondrial translation (GO:0070129) | 3.79067308 |
30 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.78414144 |
31 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.76795674 |
32 | ribosomal large subunit biogenesis (GO:0042273) | 3.74639951 |
33 | tRNA aminoacylation for protein translation (GO:0006418) | 3.68472622 |
34 | CENP-A containing nucleosome assembly (GO:0034080) | 3.65361415 |
35 | spliceosomal snRNP assembly (GO:0000387) | 3.64099393 |
36 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.63233203 |
37 | negative regulation of ligase activity (GO:0051352) | 3.63233203 |
38 | viral mRNA export from host cell nucleus (GO:0046784) | 3.62865372 |
39 | protein targeting to mitochondrion (GO:0006626) | 3.62636365 |
40 | ribosome biogenesis (GO:0042254) | 3.62537870 |
41 | DNA replication initiation (GO:0006270) | 3.62479642 |
42 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.61249107 |
43 | rRNA methylation (GO:0031167) | 3.61068177 |
44 | mitotic metaphase plate congression (GO:0007080) | 3.60823669 |
45 | tRNA aminoacylation (GO:0043039) | 3.60214016 |
46 | amino acid activation (GO:0043038) | 3.60214016 |
47 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.57617764 |
48 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.57617764 |
49 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.57617764 |
50 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.57143753 |
51 | mitotic recombination (GO:0006312) | 3.54867114 |
52 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.54760378 |
53 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.54760378 |
54 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.52700323 |
55 | NADH dehydrogenase complex assembly (GO:0010257) | 3.52700323 |
56 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.52700323 |
57 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.51251126 |
58 | DNA replication checkpoint (GO:0000076) | 3.48722835 |
59 | rRNA processing (GO:0006364) | 3.48465058 |
60 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.48433784 |
61 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.48433784 |
62 | L-methionine biosynthetic process (GO:0071265) | 3.47226102 |
63 | amino acid salvage (GO:0043102) | 3.47226102 |
64 | L-methionine salvage (GO:0071267) | 3.47226102 |
65 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.46945538 |
66 | DNA unwinding involved in DNA replication (GO:0006268) | 3.44413617 |
67 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.43183272 |
68 | chromatin remodeling at centromere (GO:0031055) | 3.43050866 |
69 | regulation of translational termination (GO:0006449) | 3.42549689 |
70 | telomere maintenance via telomere lengthening (GO:0010833) | 3.38991436 |
71 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.37861636 |
72 | 7-methylguanosine mRNA capping (GO:0006370) | 3.37814539 |
73 | de novo protein folding (GO:0006458) | 3.35999911 |
74 | RNA capping (GO:0036260) | 3.35356034 |
75 | 7-methylguanosine RNA capping (GO:0009452) | 3.35356034 |
76 | establishment of protein localization to mitochondrion (GO:0072655) | 3.34659806 |
77 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.34179486 |
78 | rRNA metabolic process (GO:0016072) | 3.34013814 |
79 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.33989155 |
80 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.33155868 |
81 | maturation of 5.8S rRNA (GO:0000460) | 3.32905729 |
82 | protein localization to mitochondrion (GO:0070585) | 3.32471352 |
83 | chaperone-mediated protein transport (GO:0072321) | 3.31965432 |
84 | positive regulation of ligase activity (GO:0051351) | 3.29642088 |
85 | mitotic nuclear envelope reassembly (GO:0007084) | 3.29466184 |
86 | nuclear envelope reassembly (GO:0031468) | 3.29466184 |
87 | spliceosomal complex assembly (GO:0000245) | 3.28637720 |
88 | regulation of ligase activity (GO:0051340) | 3.25268176 |
89 | de novo posttranslational protein folding (GO:0051084) | 3.24774326 |
90 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.24653554 |
91 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.22507897 |
92 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.22507897 |
93 | DNA damage response, detection of DNA damage (GO:0042769) | 3.22158079 |
94 | cellular component biogenesis (GO:0044085) | 3.21881089 |
95 | GDP-mannose metabolic process (GO:0019673) | 3.20138566 |
96 | * translation (GO:0006412) | 3.19984558 |
97 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.14817415 |
98 | protein complex biogenesis (GO:0070271) | 3.14740949 |
99 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.14301847 |
100 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.13244713 |
101 | viral transcription (GO:0019083) | 3.10700448 |
102 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.09926300 |
103 | termination of RNA polymerase I transcription (GO:0006363) | 3.08469173 |
104 | translational termination (GO:0006415) | 3.06984952 |
105 | ribosomal small subunit biogenesis (GO:0042274) | 3.06107508 |
106 | transcription from RNA polymerase I promoter (GO:0006360) | 3.05012212 |
107 | mismatch repair (GO:0006298) | 3.04295131 |
108 | metaphase plate congression (GO:0051310) | 3.03772463 |
109 | * tRNA processing (GO:0008033) | 3.02991398 |
110 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.02692107 |
111 | methionine biosynthetic process (GO:0009086) | 3.02542042 |
112 | intra-S DNA damage checkpoint (GO:0031573) | 3.02247828 |
113 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.01909024 |
114 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.00795617 |
115 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.99996373 |
116 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.99603770 |
117 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.99603770 |
118 | mitotic sister chromatid segregation (GO:0000070) | 2.99251580 |
119 | cotranslational protein targeting to membrane (GO:0006613) | 2.99034495 |
120 | metallo-sulfur cluster assembly (GO:0031163) | 2.98375438 |
121 | iron-sulfur cluster assembly (GO:0016226) | 2.98375438 |
122 | * tRNA methylation (GO:0030488) | 2.97929078 |
123 | kinetochore assembly (GO:0051382) | 2.97340325 |
124 | IMP biosynthetic process (GO:0006188) | 2.97045783 |
125 | respiratory chain complex IV assembly (GO:0008535) | 2.96738860 |
126 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.96331533 |
127 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.95806799 |
128 | * ncRNA processing (GO:0034470) | 2.95792100 |
129 | DNA replication-independent nucleosome organization (GO:0034724) | 2.95410728 |
130 | negative regulation of protein ubiquitination (GO:0031397) | 2.95268366 |
131 | positive regulation of cell cycle arrest (GO:0071158) | 2.92888044 |
132 | histone arginine methylation (GO:0034969) | 2.89746519 |
133 | cell cycle G1/S phase transition (GO:0044843) | 2.88834580 |
134 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.88834580 |
135 | establishment of chromosome localization (GO:0051303) | 2.85906257 |
136 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.81135413 |
137 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.78758186 |
138 | protein localization to kinetochore (GO:0034501) | 2.78140309 |
139 | regulation of translational fidelity (GO:0006450) | 2.78019053 |
140 | protein localization to chromosome, centromeric region (GO:0071459) | 2.76280931 |
141 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.75722943 |
142 | ATP synthesis coupled proton transport (GO:0015986) | 2.75722943 |
143 | protein K11-linked ubiquitination (GO:0070979) | 2.74681007 |
144 | sister chromatid segregation (GO:0000819) | 2.72946646 |
145 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.70626385 |
146 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 2.69349874 |
147 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.69022281 |
148 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.68465275 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.24974411 |
2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.51610671 |
3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.17144021 |
4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.11550153 |
5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.06965341 |
6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.85206937 |
7 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.81771287 |
8 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.61860802 |
9 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.51205013 |
10 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.50901518 |
11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.15445990 |
12 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.14185563 |
13 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.03425185 |
14 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.87494107 |
15 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.76429463 |
16 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.74502061 |
17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.73306088 |
18 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.68015970 |
19 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.62885363 |
20 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.55489766 |
21 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.43058057 |
22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.42579583 |
23 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.42396223 |
24 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.40322299 |
25 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.37083432 |
26 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.36269605 |
27 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.33705162 |
28 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.23319883 |
29 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.18561074 |
30 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.16592169 |
31 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.12517101 |
32 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.11447395 |
33 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.06550476 |
34 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.05814495 |
35 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.02410535 |
36 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.99031290 |
37 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.98121044 |
38 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.93418679 |
39 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.93220182 |
40 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.90468422 |
41 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.88735929 |
42 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.87929346 |
43 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.82451531 |
44 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.80250283 |
45 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.73161560 |
46 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.72015487 |
47 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66637721 |
48 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.66603752 |
49 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.56900902 |
50 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.56052466 |
51 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.52320282 |
52 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.51453779 |
53 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.49751419 |
54 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.48856229 |
55 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.42765047 |
56 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.42164305 |
57 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.38366128 |
58 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.36180855 |
59 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35832547 |
60 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.35155305 |
61 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.32043298 |
62 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.31839329 |
63 | * POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.29450717 |
64 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.28170636 |
65 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.26972513 |
66 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.26501772 |
67 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.26179052 |
68 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.25333258 |
69 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.24478719 |
70 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.23343865 |
71 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.20186139 |
72 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.19938695 |
73 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.17193889 |
74 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.15824835 |
75 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.15654094 |
76 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.12401655 |
77 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.11544973 |
78 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.11082615 |
79 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.08610815 |
80 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.04045701 |
81 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.03406362 |
82 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.03209450 |
83 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.02878004 |
84 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.01377587 |
85 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.99366271 |
86 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.98196655 |
87 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.95884760 |
88 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.94143433 |
89 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.94128797 |
90 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.93139245 |
91 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.93076857 |
92 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.92962760 |
93 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.92675503 |
94 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.92343623 |
95 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.91397665 |
96 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.89216847 |
97 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.89080904 |
98 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.88893996 |
99 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.86908821 |
100 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.86739094 |
101 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.86659079 |
102 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.81126774 |
103 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.80225340 |
104 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.79206523 |
105 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.77114870 |
106 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.69398928 |
107 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.69359404 |
108 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.68589402 |
109 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.68547634 |
110 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.68492698 |
111 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.63755368 |
112 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.63083360 |
113 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.62678630 |
114 | * YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.61173718 |
115 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.60921412 |
116 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.60146215 |
117 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.58820106 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 4.47655871 |
2 | MP0010094_abnormal_chromosome_stability | 3.82827842 |
3 | MP0008058_abnormal_DNA_repair | 3.60736959 |
4 | MP0003111_abnormal_nucleus_morphology | 3.44331761 |
5 | MP0001986_abnormal_taste_sensitivity | 3.37478263 |
6 | MP0004957_abnormal_blastocyst_morpholog | 3.33176823 |
7 | MP0008057_abnormal_DNA_replication | 3.30812231 |
8 | MP0006292_abnormal_olfactory_placode | 3.12938769 |
9 | MP0004147_increased_porphyrin_level | 2.95227139 |
10 | MP0003077_abnormal_cell_cycle | 2.86546923 |
11 | MP0005075_abnormal_melanosome_morpholog | 2.85647735 |
12 | MP0002132_abnormal_respiratory_system | 2.60776904 |
13 | MP0003718_maternal_effect | 2.59316538 |
14 | MP0003950_abnormal_plasma_membrane | 2.58217386 |
15 | MP0003806_abnormal_nucleotide_metabolis | 2.44270806 |
16 | MP0008932_abnormal_embryonic_tissue | 2.42189137 |
17 | MP0009379_abnormal_foot_pigmentation | 2.32909867 |
18 | MP0003656_abnormal_erythrocyte_physiolo | 2.29122252 |
19 | MP0008877_abnormal_DNA_methylation | 2.21702062 |
20 | MP0003786_premature_aging | 2.12743690 |
21 | MP0008438_abnormal_cutaneous_collagen | 2.11486024 |
22 | MP0001188_hyperpigmentation | 2.00506212 |
23 | MP0004233_abnormal_muscle_weight | 1.96613317 |
24 | MP0002396_abnormal_hematopoietic_system | 1.96447634 |
25 | MP0001764_abnormal_homeostasis | 1.96030047 |
26 | MP0008007_abnormal_cellular_replicative | 1.91193260 |
27 | MP0009697_abnormal_copulation | 1.87203448 |
28 | MP0002877_abnormal_melanocyte_morpholog | 1.86353430 |
29 | MP0000358_abnormal_cell_content/ | 1.76627269 |
30 | MP0003566_abnormal_cell_adhesion | 1.76233308 |
31 | MP0006036_abnormal_mitochondrial_physio | 1.75941491 |
32 | MP0009333_abnormal_splenocyte_physiolog | 1.74375609 |
33 | MP0003186_abnormal_redox_activity | 1.74065574 |
34 | MP0005501_abnormal_skin_physiology | 1.72146044 |
35 | MP0000490_abnormal_crypts_of | 1.71310216 |
36 | MP0000749_muscle_degeneration | 1.69819174 |
37 | MP0002060_abnormal_skin_morphology | 1.68673452 |
38 | MP0001529_abnormal_vocalization | 1.68581448 |
39 | MP0002938_white_spotting | 1.60323609 |
40 | MP0008260_abnormal_autophagy | 1.59793288 |
41 | MP0004272_abnormal_basement_membrane | 1.59027073 |
42 | MP0000751_myopathy | 1.58586123 |
43 | MP0005623_abnormal_meninges_morphology | 1.57132158 |
44 | MP0000762_abnormal_tongue_morphology | 1.54445683 |
45 | MP0005257_abnormal_intraocular_pressure | 1.52219845 |
46 | MP0003221_abnormal_cardiomyocyte_apopto | 1.44566191 |
47 | MP0000015_abnormal_ear_pigmentation | 1.36752563 |
48 | MP0005671_abnormal_response_to | 1.36436096 |
49 | MP0003763_abnormal_thymus_physiology | 1.34241832 |
50 | MP0000750_abnormal_muscle_regeneration | 1.32144969 |
51 | MP0006035_abnormal_mitochondrial_morpho | 1.32010191 |
52 | MP0009053_abnormal_anal_canal | 1.31990963 |
53 | MP0002876_abnormal_thyroid_physiology | 1.31467807 |
54 | MP0004381_abnormal_hair_follicle | 1.30480038 |
55 | MP0003123_paternal_imprinting | 1.25173297 |
56 | MP0002160_abnormal_reproductive_system | 1.24270901 |
57 | MP0002234_abnormal_pharynx_morphology | 1.23715493 |
58 | MP0001661_extended_life_span | 1.23632126 |
59 | MP0005389_reproductive_system_phenotype | 1.22284830 |
60 | MP0004133_heterotaxia | 1.22186464 |
61 | MP0001216_abnormal_epidermal_layer | 1.19797168 |
62 | MP0000372_irregular_coat_pigmentation | 1.18423832 |
63 | MP0002095_abnormal_skin_pigmentation | 1.18171800 |
64 | MP0001243_abnormal_dermal_layer | 1.17994287 |
65 | MP0003890_abnormal_embryonic-extraembry | 1.17485723 |
66 | MP0005174_abnormal_tail_pigmentation | 1.16574703 |
67 | MP0002210_abnormal_sex_determination | 1.14512751 |
68 | MP0000579_abnormal_nail_morphology | 1.12691945 |
69 | MP0001919_abnormal_reproductive_system | 1.11282896 |
70 | MP0003136_yellow_coat_color | 1.09700008 |
71 | MP0000537_abnormal_urethra_morphology | 1.08979463 |
72 | MP0003385_abnormal_body_wall | 1.08218788 |
73 | MP0001849_ear_inflammation | 1.07684967 |
74 | MP0002796_impaired_skin_barrier | 1.07048664 |
75 | MP0001905_abnormal_dopamine_level | 1.06014442 |
76 | MP0001730_embryonic_growth_arrest | 1.05619717 |
77 | MP0005384_cellular_phenotype | 1.05268603 |
78 | MP0005646_abnormal_pituitary_gland | 1.04851669 |
79 | MP0001299_abnormal_eye_distance/ | 1.04365481 |
80 | MP0003941_abnormal_skin_development | 1.04341652 |
81 | MP0003121_genomic_imprinting | 1.04300251 |
82 | MP0000467_abnormal_esophagus_morphology | 1.04205086 |
83 | MP0002163_abnormal_gland_morphology | 1.03382074 |
84 | MP0005023_abnormal_wound_healing | 1.02652062 |
85 | MP0010771_integument_phenotype | 0.99923547 |
86 | MP0000313_abnormal_cell_death | 0.99766832 |
87 | MP0003787_abnormal_imprinting | 0.99284853 |
88 | MP0003705_abnormal_hypodermis_morpholog | 0.99018035 |
89 | MP0005367_renal/urinary_system_phenotyp | 0.98445921 |
90 | MP0000516_abnormal_urinary_system | 0.98445921 |
91 | MP0001881_abnormal_mammary_gland | 0.98303401 |
92 | MP0002019_abnormal_tumor_incidence | 0.96948772 |
93 | MP0000350_abnormal_cell_proliferation | 0.95504099 |
94 | MP0000689_abnormal_spleen_morphology | 0.94570543 |
95 | MP0005084_abnormal_gallbladder_morpholo | 0.92526771 |
96 | MP0002398_abnormal_bone_marrow | 0.91242656 |
97 | MP0010234_abnormal_vibrissa_follicle | 0.90311224 |
98 | MP0001119_abnormal_female_reproductive | 0.90202957 |
99 | MP0005621_abnormal_cell_physiology | 0.89773038 |
100 | MP0002102_abnormal_ear_morphology | 0.89460891 |
101 | MP0004264_abnormal_extraembryonic_tissu | 0.88525705 |
102 | MP0001853_heart_inflammation | 0.88166140 |
103 | MP0001542_abnormal_bone_strength | 0.86504721 |
104 | MP0002722_abnormal_immune_system | 0.86244754 |
105 | MP0001145_abnormal_male_reproductive | 0.86063483 |
106 | MP0010352_gastrointestinal_tract_polyps | 0.85952377 |
107 | MP0002084_abnormal_developmental_patter | 0.85859209 |
108 | MP0003984_embryonic_growth_retardation | 0.85281102 |
109 | MP0003755_abnormal_palate_morphology | 0.85255481 |
110 | MP0005451_abnormal_body_composition | 0.83323561 |
111 | MP0000049_abnormal_middle_ear | 0.82911210 |
112 | MP0001545_abnormal_hematopoietic_system | 0.82836468 |
113 | MP0005397_hematopoietic_system_phenotyp | 0.82836468 |
114 | MP0001697_abnormal_embryo_size | 0.82805227 |
115 | MP0005645_abnormal_hypothalamus_physiol | 0.82450747 |
116 | MP0000858_altered_metastatic_potential | 0.81213527 |
117 | MP0002080_prenatal_lethality | 0.81062217 |
118 | MP0003195_calcinosis | 0.81006943 |
119 | MP0002177_abnormal_outer_ear | 0.80278653 |
120 | MP0002638_abnormal_pupillary_reflex | 0.80252615 |
121 | MP0001672_abnormal_embryogenesis/_devel | 0.79024397 |
122 | MP0005380_embryogenesis_phenotype | 0.79024397 |
123 | MP0002277_abnormal_respiratory_mucosa | 0.78860106 |
124 | MP0000653_abnormal_sex_gland | 0.78827644 |
125 | MP0002088_abnormal_embryonic_growth/wei | 0.78347426 |
126 | MP0009250_abnormal_appendicular_skeleto | 0.77592386 |
127 | MP0008995_early_reproductive_senescence | 0.77088527 |
128 | MP0002751_abnormal_autonomic_nervous | 0.76251304 |
129 | MP0000566_synostosis | 0.74983189 |
130 | MP0001727_abnormal_embryo_implantation | 0.74246152 |
131 | MP0000678_abnormal_parathyroid_gland | 0.73939187 |
132 | MP0003567_abnormal_fetal_cardiomyocyte | 0.73663798 |
133 | MP0002086_abnormal_extraembryonic_tissu | 0.73472195 |
134 | MP0000703_abnormal_thymus_morphology | 0.73191587 |
135 | MP0003315_abnormal_perineum_morphology | 0.72570535 |
136 | MP0000759_abnormal_skeletal_muscle | 0.72378985 |
137 | MP0002429_abnormal_blood_cell | 0.71400689 |
138 | MP0001929_abnormal_gametogenesis | 0.71010247 |
139 | MP0005408_hypopigmentation | 0.70692547 |
140 | MP0005394_taste/olfaction_phenotype | 0.70352533 |
141 | MP0005499_abnormal_olfactory_system | 0.70352533 |
142 | MP0005197_abnormal_uvea_morphology | 0.69285488 |
143 | MP0004197_abnormal_fetal_growth/weight/ | 0.69272341 |
144 | MP0000627_abnormal_mammary_gland | 0.68726213 |
145 | MP0008004_abnormal_stomach_pH | 0.68281746 |
146 | MP0010030_abnormal_orbit_morphology | 0.68051469 |
147 | MP0005330_cardiomyopathy | 0.67635770 |
148 | MP0008789_abnormal_olfactory_epithelium | 0.67432333 |
149 | MP0005220_abnormal_exocrine_pancreas | 0.66828316 |
150 | MP0005171_absent_coat_pigmentation | 0.66353696 |
151 | MP0005670_abnormal_white_adipose | 0.66201467 |
152 | MP0001191_abnormal_skin_condition | 0.65375886 |
153 | MP0001186_pigmentation_phenotype | 0.65013497 |
154 | MP0005636_abnormal_mineral_homeostasis | 0.64737350 |
155 | MP0005193_abnormal_anterior_eye | 0.64418023 |
156 | MP0009931_abnormal_skin_appearance | 0.63605338 |
157 | MP0005395_other_phenotype | 0.63241944 |
158 | MP0005379_endocrine/exocrine_gland_phen | 0.63191508 |
159 | MP0003011_delayed_dark_adaptation | 0.62705921 |
160 | MP0002269_muscular_atrophy | 0.62198371 |
161 | MP0002085_abnormal_embryonic_tissue | 0.61602309 |
162 | MP0002148_abnormal_hypersensitivity_rea | 0.61149638 |
163 | MP0001293_anophthalmia | 0.59600718 |
164 | MP0000733_abnormal_muscle_development | 0.57703703 |
165 | MP0008873_increased_physiological_sensi | 0.57572980 |
166 | MP0002282_abnormal_trachea_morphology | 0.57047517 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 4.24835633 |
2 | Type I transferrin isoform profile (HP:0003642) | 3.89521339 |
3 | Abnormal number of erythroid precursors (HP:0012131) | 3.81474214 |
4 | Mitochondrial inheritance (HP:0001427) | 3.74314996 |
5 | Acute necrotizing encephalopathy (HP:0006965) | 3.66178322 |
6 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.65845424 |
7 | Abnormality of placental membranes (HP:0011409) | 3.64742228 |
8 | Amniotic constriction ring (HP:0009775) | 3.64742228 |
9 | Increased CSF lactate (HP:0002490) | 3.60437820 |
10 | Hepatocellular necrosis (HP:0001404) | 3.59530477 |
11 | Increased hepatocellular lipid droplets (HP:0006565) | 3.52042319 |
12 | Increased serum lactate (HP:0002151) | 3.46603559 |
13 | 3-Methylglutaconic aciduria (HP:0003535) | 3.41372905 |
14 | Reticulocytopenia (HP:0001896) | 3.40131410 |
15 | Birth length less than 3rd percentile (HP:0003561) | 3.37039915 |
16 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.34679924 |
17 | Premature rupture of membranes (HP:0001788) | 3.32804865 |
18 | Aplastic anemia (HP:0001915) | 3.30008742 |
19 | Cerebral hypomyelination (HP:0006808) | 3.29799260 |
20 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.29379511 |
21 | Abnormality of alanine metabolism (HP:0010916) | 3.29379511 |
22 | Hyperalaninemia (HP:0003348) | 3.29379511 |
23 | Lipid accumulation in hepatocytes (HP:0006561) | 3.28600540 |
24 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.28564295 |
25 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.25300660 |
26 | Chromsome breakage (HP:0040012) | 3.23642393 |
27 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.15759881 |
28 | Abnormalities of placenta or umbilical cord (HP:0001194) | 3.07155971 |
29 | Hepatic necrosis (HP:0002605) | 3.06877027 |
30 | Entropion (HP:0000621) | 3.06719148 |
31 | Reduced subcutaneous adipose tissue (HP:0003758) | 3.06490010 |
32 | Acute encephalopathy (HP:0006846) | 3.04196927 |
33 | Abnormality of the umbilical cord (HP:0010881) | 3.03560297 |
34 | Microvesicular hepatic steatosis (HP:0001414) | 2.97928447 |
35 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.93714595 |
36 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.93714595 |
37 | Upper limb muscle weakness (HP:0003484) | 2.89968788 |
38 | Reduced antithrombin III activity (HP:0001976) | 2.87693187 |
39 | Renal Fanconi syndrome (HP:0001994) | 2.74916069 |
40 | Progressive macrocephaly (HP:0004481) | 2.72305688 |
41 | Abnormal glycosylation (HP:0012345) | 2.71471210 |
42 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.71471210 |
43 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.71471210 |
44 | Abnormal protein glycosylation (HP:0012346) | 2.71471210 |
45 | Lactic acidosis (HP:0003128) | 2.71099241 |
46 | Shoulder girdle muscle weakness (HP:0003547) | 2.69781818 |
47 | Exertional dyspnea (HP:0002875) | 2.59381907 |
48 | Onycholysis (HP:0001806) | 2.59235440 |
49 | Rough bone trabeculation (HP:0100670) | 2.56866723 |
50 | Abnormality of glycolysis (HP:0004366) | 2.53195230 |
51 | Increased serum pyruvate (HP:0003542) | 2.53195230 |
52 | Oral leukoplakia (HP:0002745) | 2.51388417 |
53 | Cholecystitis (HP:0001082) | 2.51298862 |
54 | Abnormal gallbladder physiology (HP:0012438) | 2.51298862 |
55 | Proximal placement of thumb (HP:0009623) | 2.48656696 |
56 | Pallor (HP:0000980) | 2.48260968 |
57 | Macrocytic anemia (HP:0001972) | 2.47890655 |
58 | Premature graying of hair (HP:0002216) | 2.46998874 |
59 | Abnormality of the preputium (HP:0100587) | 2.46467067 |
60 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.43975517 |
61 | Abnormality of the ileum (HP:0001549) | 2.41419639 |
62 | Single umbilical artery (HP:0001195) | 2.41286809 |
63 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.41286809 |
64 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.41286809 |
65 | Squamous cell carcinoma (HP:0002860) | 2.39351680 |
66 | Breast hypoplasia (HP:0003187) | 2.38166354 |
67 | Meckel diverticulum (HP:0002245) | 2.37981926 |
68 | Deviation of the thumb (HP:0009603) | 2.37745279 |
69 | Exercise intolerance (HP:0003546) | 2.36286956 |
70 | Vertebral compression fractures (HP:0002953) | 2.32617863 |
71 | Respiratory difficulties (HP:0002880) | 2.31441382 |
72 | Selective tooth agenesis (HP:0001592) | 2.28679576 |
73 | Respiratory failure (HP:0002878) | 2.28586186 |
74 | Sparse eyelashes (HP:0000653) | 2.28354931 |
75 | Short nail (HP:0001799) | 2.27763842 |
76 | Fragile nails (HP:0001808) | 2.24808879 |
77 | Patellar aplasia (HP:0006443) | 2.24282845 |
78 | Degeneration of anterior horn cells (HP:0002398) | 2.21225861 |
79 | Abnormality of the anterior horn cell (HP:0006802) | 2.21225861 |
80 | Type 2 muscle fiber atrophy (HP:0003554) | 2.18722185 |
81 | Duplicated collecting system (HP:0000081) | 2.17297410 |
82 | Multiple enchondromatosis (HP:0005701) | 2.16712895 |
83 | Progressive muscle weakness (HP:0003323) | 2.16565736 |
84 | Limb-girdle muscle atrophy (HP:0003797) | 2.16556183 |
85 | Carpal bone hypoplasia (HP:0001498) | 2.16127639 |
86 | Pelvic girdle muscle weakness (HP:0003749) | 2.15975050 |
87 | Nail dystrophy (HP:0008404) | 2.15893742 |
88 | Pancytopenia (HP:0001876) | 2.14968472 |
89 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.14837022 |
90 | Atrophic scars (HP:0001075) | 2.12769818 |
91 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.12418277 |
92 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.12418277 |
93 | Hypoplastic pelvis (HP:0008839) | 2.10290319 |
94 | IgM deficiency (HP:0002850) | 2.09596714 |
95 | Abnormality of the renal collecting system (HP:0004742) | 2.07845575 |
96 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.07155015 |
97 | Bone marrow hypocellularity (HP:0005528) | 2.06128168 |
98 | Poikiloderma (HP:0001029) | 2.05954602 |
99 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.05300032 |
100 | CNS demyelination (HP:0007305) | 2.05266282 |
101 | Abnormality of renal resorption (HP:0011038) | 2.03496492 |
102 | Poor head control (HP:0002421) | 2.02924119 |
103 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.01199351 |
104 | Abnormal lung lobation (HP:0002101) | 2.00557087 |
105 | Cerebral edema (HP:0002181) | 1.99571173 |
106 | Increased intramyocellular lipid droplets (HP:0012240) | 1.97355943 |
107 | Prominent metopic ridge (HP:0005487) | 1.96321372 |
108 | Muscle fiber atrophy (HP:0100295) | 1.95879297 |
109 | Abnormality of chromosome stability (HP:0003220) | 1.95507413 |
110 | Opisthotonus (HP:0002179) | 1.95388784 |
111 | Abnormality of the pons (HP:0007361) | 1.94233995 |
112 | Glucose intolerance (HP:0000833) | 1.94164150 |
113 | Postnatal microcephaly (HP:0005484) | 1.92896275 |
114 | Secondary amenorrhea (HP:0000869) | 1.92501178 |
115 | Optic disc pallor (HP:0000543) | 1.92022291 |
116 | Emotional lability (HP:0000712) | 1.90955596 |
117 | True hermaphroditism (HP:0010459) | 1.90639452 |
118 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.89937665 |
119 | Hypokinesia (HP:0002375) | 1.89497179 |
120 | CNS hypomyelination (HP:0003429) | 1.86238459 |
121 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.85220288 |
122 | Megaloblastic anemia (HP:0001889) | 1.85031476 |
123 | Spastic diplegia (HP:0001264) | 1.84349124 |
124 | Horseshoe kidney (HP:0000085) | 1.83720267 |
125 | Ureteral duplication (HP:0000073) | 1.83237641 |
126 | Poor suck (HP:0002033) | 1.82827988 |
127 | Plantar hyperkeratosis (HP:0007556) | 1.82042514 |
128 | Hand muscle atrophy (HP:0009130) | 1.81950612 |
129 | Congenital, generalized hypertrichosis (HP:0004540) | 1.80965337 |
130 | 11 pairs of ribs (HP:0000878) | 1.80844837 |
131 | Absent thumb (HP:0009777) | 1.80635614 |
132 | Abnormality of serum amino acid levels (HP:0003112) | 1.80448918 |
133 | Renal cortical cysts (HP:0000803) | 1.80091679 |
134 | Death in infancy (HP:0001522) | 1.79424375 |
135 | Redundant skin (HP:0001582) | 1.79233583 |
136 | Generalized amyotrophy (HP:0003700) | 1.78990615 |
137 | Abnormal trabecular bone morphology (HP:0100671) | 1.77037978 |
138 | Myelodysplasia (HP:0002863) | 1.76936370 |
139 | Triphalangeal thumb (HP:0001199) | 1.76246202 |
140 | Hypoplasia of the pons (HP:0012110) | 1.75855961 |
141 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.75689005 |
142 | Methylmalonic aciduria (HP:0012120) | 1.75145818 |
143 | Petechiae (HP:0000967) | 1.74771146 |
144 | Impulsivity (HP:0100710) | 1.74648853 |
145 | Absent radius (HP:0003974) | 1.74595151 |
146 | Cellular immunodeficiency (HP:0005374) | 1.74560192 |
147 | Ragged-red muscle fibers (HP:0003200) | 1.74050295 |
148 | Trismus (HP:0000211) | 1.73368142 |
149 | Microglossia (HP:0000171) | 1.73367332 |
150 | Retinal dysplasia (HP:0007973) | 1.70989058 |
151 | Cutaneous melanoma (HP:0012056) | 1.70676467 |
152 | Premature ovarian failure (HP:0008209) | 1.69657177 |
Rank | Gene Set | Z-score |
---|---|---|
1 | STK16 | 4.82744429 |
2 | BUB1 | 4.70797685 |
3 | VRK2 | 4.32753473 |
4 | EIF2AK1 | 3.99850569 |
5 | WEE1 | 3.01505082 |
6 | TESK1 | 2.89171240 |
7 | EIF2AK3 | 2.64949999 |
8 | SRPK1 | 2.62992677 |
9 | TLK1 | 2.29657492 |
10 | VRK1 | 2.09813927 |
11 | IRAK4 | 2.01826920 |
12 | NME2 | 2.01347974 |
13 | CDC7 | 1.90818840 |
14 | TSSK6 | 1.86717640 |
15 | MKNK1 | 1.83257559 |
16 | ZAK | 1.83089827 |
17 | MST1R | 1.77266466 |
18 | SCYL2 | 1.75834119 |
19 | DYRK3 | 1.65653866 |
20 | PAK4 | 1.60470551 |
21 | TESK2 | 1.60432738 |
22 | TRIM28 | 1.58763235 |
23 | CCNB1 | 1.55873288 |
24 | PIM2 | 1.55331672 |
25 | PLK4 | 1.55293815 |
26 | BRSK2 | 1.51557704 |
27 | MAP3K11 | 1.48150879 |
28 | SMG1 | 1.42982843 |
29 | NME1 | 1.40691928 |
30 | PLK1 | 1.39900559 |
31 | ARAF | 1.37262172 |
32 | AKT3 | 1.31436493 |
33 | WNK3 | 1.28371418 |
34 | ERBB4 | 1.27333122 |
35 | DYRK2 | 1.23419804 |
36 | PDK2 | 1.22356411 |
37 | MKNK2 | 1.22277843 |
38 | CDK19 | 1.19301073 |
39 | NLK | 1.18045214 |
40 | CDK7 | 1.16599523 |
41 | TEC | 1.16487429 |
42 | TTK | 1.16004036 |
43 | CDK8 | 1.14378165 |
44 | NEK2 | 1.14112556 |
45 | MAPKAPK5 | 1.13515122 |
46 | STK10 | 1.13326880 |
47 | ATR | 1.10847726 |
48 | NUAK1 | 1.08829399 |
49 | CSNK1A1L | 1.08220728 |
50 | ACVR1B | 1.07998974 |
51 | EIF2AK2 | 1.07793088 |
52 | AURKB | 1.06645345 |
53 | TNK2 | 1.04671897 |
54 | KDR | 1.02668501 |
55 | PLK3 | 1.00813938 |
56 | AURKA | 1.00497205 |
57 | ILK | 1.00173770 |
58 | IRAK2 | 0.97612120 |
59 | BRSK1 | 0.97082830 |
60 | CHEK2 | 0.96845630 |
61 | IRAK3 | 0.94241448 |
62 | YES1 | 0.92944192 |
63 | BCKDK | 0.91249044 |
64 | CASK | 0.90411079 |
65 | LMTK2 | 0.88069302 |
66 | CSNK1G2 | 0.87660773 |
67 | TAF1 | 0.86412652 |
68 | BRAF | 0.86057685 |
69 | EPHA2 | 0.85491356 |
70 | RPS6KB2 | 0.85466895 |
71 | MAP3K12 | 0.84956792 |
72 | MAP4K1 | 0.83000877 |
73 | MAP4K2 | 0.82495019 |
74 | PASK | 0.82017386 |
75 | ADRBK2 | 0.80500104 |
76 | MAP2K7 | 0.79254342 |
77 | ABL2 | 0.76761708 |
78 | MAP3K8 | 0.75613376 |
79 | CLK1 | 0.75389752 |
80 | CSNK2A1 | 0.73536655 |
81 | MET | 0.72182688 |
82 | IRAK1 | 0.72129396 |
83 | RPS6KA5 | 0.68954686 |
84 | MST4 | 0.68212528 |
85 | CHEK1 | 0.63986532 |
86 | PTK2 | 0.63827236 |
87 | DAPK3 | 0.62379302 |
88 | TXK | 0.60428922 |
89 | NEK1 | 0.59795809 |
90 | CSNK2A2 | 0.59130840 |
91 | DAPK1 | 0.59030159 |
92 | GRK1 | 0.58551838 |
93 | MAPK13 | 0.56790036 |
94 | TNIK | 0.56292718 |
95 | FLT3 | 0.56158137 |
96 | MUSK | 0.55925418 |
97 | BTK | 0.55900457 |
98 | STK38L | 0.54594303 |
99 | ERBB3 | 0.52329265 |
100 | CSNK1G3 | 0.51510494 |
101 | SIK3 | 0.51234482 |
102 | CDK3 | 0.51159998 |
103 | MOS | 0.51129501 |
104 | PRKCI | 0.49787297 |
105 | PBK | 0.49745281 |
106 | EPHB2 | 0.48536763 |
107 | PRPF4B | 0.48444751 |
108 | MYLK | 0.47530568 |
109 | CDK14 | 0.47305127 |
110 | TAOK2 | 0.46743223 |
111 | PINK1 | 0.45668012 |
112 | UHMK1 | 0.45459597 |
113 | BMPR1B | 0.45398696 |
114 | PIM1 | 0.45388944 |
115 | RAF1 | 0.44472026 |
116 | CDK18 | 0.40797173 |
117 | CDK2 | 0.40448621 |
118 | RPS6KA4 | 0.39901961 |
119 | BLK | 0.38771354 |
120 | CDK11A | 0.38530096 |
121 | ATM | 0.37975985 |
122 | CSNK1G1 | 0.37501693 |
123 | CDK9 | 0.37072737 |
124 | MAPKAPK3 | 0.36294801 |
125 | CDK15 | 0.36082304 |
126 | STK4 | 0.36076307 |
127 | LIMK1 | 0.35623459 |
128 | CAMKK2 | 0.35395542 |
129 | BCR | 0.34795975 |
130 | LYN | 0.34674471 |
131 | CDK1 | 0.34040203 |
132 | MAPK15 | 0.32661064 |
133 | PAK1 | 0.29849668 |
134 | GRK7 | 0.28868000 |
135 | MAPK11 | 0.28397587 |
136 | TTN | 0.28308754 |
137 | PAK2 | 0.28108067 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.24932383 |
2 | DNA replication_Homo sapiens_hsa03030 | 4.15631727 |
3 | Mismatch repair_Homo sapiens_hsa03430 | 4.11243318 |
4 | Ribosome_Homo sapiens_hsa03010 | 3.66800922 |
5 | RNA polymerase_Homo sapiens_hsa03020 | 3.56068208 |
6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.21155808 |
7 | Spliceosome_Homo sapiens_hsa03040 | 2.90880855 |
8 | Base excision repair_Homo sapiens_hsa03410 | 2.89546989 |
9 | Homologous recombination_Homo sapiens_hsa03440 | 2.86322247 |
10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.68196770 |
11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.55999595 |
12 | Protein export_Homo sapiens_hsa03060 | 2.34183632 |
13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.33704237 |
14 | RNA transport_Homo sapiens_hsa03013 | 2.25213808 |
15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.17843407 |
16 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.97676234 |
17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.87563657 |
18 | Parkinsons disease_Homo sapiens_hsa05012 | 1.82032797 |
19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.81094103 |
20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.75780550 |
21 | Cell cycle_Homo sapiens_hsa04110 | 1.67929564 |
22 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.67611211 |
23 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.61365982 |
24 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.58419830 |
25 | RNA degradation_Homo sapiens_hsa03018 | 1.57747806 |
26 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.48129751 |
27 | Purine metabolism_Homo sapiens_hsa00230 | 1.45540060 |
28 | Huntingtons disease_Homo sapiens_hsa05016 | 1.38568786 |
29 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.32128795 |
30 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.28906287 |
31 | Sulfur relay system_Homo sapiens_hsa04122 | 1.27323541 |
32 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.19332678 |
33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.13420141 |
34 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.10224017 |
35 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.05782034 |
36 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.05130823 |
37 | Shigellosis_Homo sapiens_hsa05131 | 1.03456803 |
38 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.02569061 |
39 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.99936659 |
40 | Alzheimers disease_Homo sapiens_hsa05010 | 0.97058585 |
41 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.96998855 |
42 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.96273947 |
43 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.93484304 |
44 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.88094215 |
45 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.83977589 |
46 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.79594863 |
47 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.78144505 |
48 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.78117208 |
49 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.77779109 |
50 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.76101749 |
51 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.75248285 |
52 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.73754735 |
53 | Metabolic pathways_Homo sapiens_hsa01100 | 0.72906373 |
54 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.70506405 |
55 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.68664217 |
56 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.68301610 |
57 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.65863758 |
58 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.64516408 |
59 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.62083126 |
60 | Other glycan degradation_Homo sapiens_hsa00511 | 0.60552317 |
61 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.58512735 |
62 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.56873582 |
63 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.56192963 |
64 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.55377462 |
65 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.53755219 |
66 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.53509141 |
67 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.50360223 |
68 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.47349863 |
69 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.47017672 |
70 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.46787429 |
71 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.46421752 |
72 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.46373616 |
73 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.45507475 |
74 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.45201796 |
75 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.45003163 |
76 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.43739247 |
77 | Salmonella infection_Homo sapiens_hsa05132 | 0.43516720 |
78 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.41935219 |
79 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.38623794 |
80 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.37182999 |
81 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.36774205 |
82 | Carbon metabolism_Homo sapiens_hsa01200 | 0.36721045 |
83 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.36522370 |
84 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.33867294 |
85 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.33187916 |
86 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.32719292 |
87 | Bladder cancer_Homo sapiens_hsa05219 | 0.32366078 |
88 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.30912898 |
89 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.30635355 |
90 | Apoptosis_Homo sapiens_hsa04210 | 0.29931669 |
91 | Allograft rejection_Homo sapiens_hsa05330 | 0.27626231 |
92 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.27329518 |
93 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.27213983 |
94 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.26426453 |
95 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.25964804 |
96 | Peroxisome_Homo sapiens_hsa04146 | 0.24522041 |
97 | Thyroid cancer_Homo sapiens_hsa05216 | 0.24509300 |
98 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.22998976 |
99 | HTLV-I infection_Homo sapiens_hsa05166 | 0.22185366 |
100 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.20715267 |
101 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.18641506 |
102 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.18482437 |
103 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.17532856 |
104 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.16381677 |
105 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.15918376 |
106 | Endocytosis_Homo sapiens_hsa04144 | 0.15585089 |
107 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.15386883 |
108 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.14616980 |
109 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.14312833 |
110 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.14046502 |
111 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.12581831 |
112 | Measles_Homo sapiens_hsa05162 | 0.12547591 |
113 | Retinol metabolism_Homo sapiens_hsa00830 | 0.11894131 |
114 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.11809638 |
115 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.10112789 |
116 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.10081609 |
117 | Legionellosis_Homo sapiens_hsa05134 | 0.10060553 |
118 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.09850836 |
119 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.09515513 |
120 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.08499661 |
121 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.08430163 |
122 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.08009720 |
123 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.07618050 |
124 | Alcoholism_Homo sapiens_hsa05034 | 0.07444905 |
125 | Galactose metabolism_Homo sapiens_hsa00052 | 0.06428923 |