FTSJ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.02929852
2ribosome assembly (GO:0042255)4.99582076
3establishment of integrated proviral latency (GO:0075713)4.96249216
4ribosomal small subunit assembly (GO:0000028)4.71774152
5establishment of viral latency (GO:0019043)4.63080350
6proteasome assembly (GO:0043248)4.61995776
7protein maturation by protein folding (GO:0022417)4.58220952
8telomere maintenance via semi-conservative replication (GO:0032201)4.47274559
9rRNA modification (GO:0000154)4.30328008
10DNA strand elongation involved in DNA replication (GO:0006271)4.26747892
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.20770623
12pseudouridine synthesis (GO:0001522)4.20397244
13termination of RNA polymerase III transcription (GO:0006386)4.16404016
14transcription elongation from RNA polymerase III promoter (GO:0006385)4.16404016
15Golgi transport vesicle coating (GO:0048200)4.15804195
16COPI coating of Golgi vesicle (GO:0048205)4.15804195
17formation of translation preinitiation complex (GO:0001731)4.10057550
18DNA strand elongation (GO:0022616)4.09399979
19L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.03982813
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.03529832
21nucleobase biosynthetic process (GO:0046112)4.02217028
22telomere maintenance via recombination (GO:0000722)3.98983283
23cullin deneddylation (GO:0010388)3.98184538
24maturation of SSU-rRNA (GO:0030490)3.93380946
25protein deneddylation (GO:0000338)3.87056152
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.85563367
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81993890
28purine nucleobase biosynthetic process (GO:0009113)3.81234404
29regulation of mitochondrial translation (GO:0070129)3.79067308
30nucleobase-containing small molecule interconversion (GO:0015949)3.78414144
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.76795674
32ribosomal large subunit biogenesis (GO:0042273)3.74639951
33tRNA aminoacylation for protein translation (GO:0006418)3.68472622
34CENP-A containing nucleosome assembly (GO:0034080)3.65361415
35spliceosomal snRNP assembly (GO:0000387)3.64099393
36negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.63233203
37negative regulation of ligase activity (GO:0051352)3.63233203
38viral mRNA export from host cell nucleus (GO:0046784)3.62865372
39protein targeting to mitochondrion (GO:0006626)3.62636365
40ribosome biogenesis (GO:0042254)3.62537870
41DNA replication initiation (GO:0006270)3.62479642
42DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.61249107
43rRNA methylation (GO:0031167)3.61068177
44mitotic metaphase plate congression (GO:0007080)3.60823669
45tRNA aminoacylation (GO:0043039)3.60214016
46amino acid activation (GO:0043038)3.60214016
47signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.57617764
48signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.57617764
49signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.57617764
50regulation of cellular amino acid metabolic process (GO:0006521)3.57143753
51mitotic recombination (GO:0006312)3.54867114
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54760378
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54760378
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.52700323
55NADH dehydrogenase complex assembly (GO:0010257)3.52700323
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52700323
57ribonucleoprotein complex biogenesis (GO:0022613)3.51251126
58DNA replication checkpoint (GO:0000076)3.48722835
59rRNA processing (GO:0006364)3.48465058
60signal transduction involved in DNA integrity checkpoint (GO:0072401)3.48433784
61signal transduction involved in DNA damage checkpoint (GO:0072422)3.48433784
62L-methionine biosynthetic process (GO:0071265)3.47226102
63amino acid salvage (GO:0043102)3.47226102
64L-methionine salvage (GO:0071267)3.47226102
65signal transduction involved in cell cycle checkpoint (GO:0072395)3.46945538
66DNA unwinding involved in DNA replication (GO:0006268)3.44413617
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.43183272
68chromatin remodeling at centromere (GO:0031055)3.43050866
69regulation of translational termination (GO:0006449)3.42549689
70telomere maintenance via telomere lengthening (GO:0010833)3.38991436
71regulation of ubiquitin-protein transferase activity (GO:0051438)3.37861636
727-methylguanosine mRNA capping (GO:0006370)3.37814539
73de novo protein folding (GO:0006458)3.35999911
74RNA capping (GO:0036260)3.35356034
757-methylguanosine RNA capping (GO:0009452)3.35356034
76establishment of protein localization to mitochondrion (GO:0072655)3.34659806
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34179486
78rRNA metabolic process (GO:0016072)3.34013814
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.33989155
80establishment of protein localization to mitochondrial membrane (GO:0090151)3.33155868
81maturation of 5.8S rRNA (GO:0000460)3.32905729
82protein localization to mitochondrion (GO:0070585)3.32471352
83chaperone-mediated protein transport (GO:0072321)3.31965432
84positive regulation of ligase activity (GO:0051351)3.29642088
85mitotic nuclear envelope reassembly (GO:0007084)3.29466184
86nuclear envelope reassembly (GO:0031468)3.29466184
87spliceosomal complex assembly (GO:0000245)3.28637720
88regulation of ligase activity (GO:0051340)3.25268176
89de novo posttranslational protein folding (GO:0051084)3.24774326
90transcription-coupled nucleotide-excision repair (GO:0006283)3.24653554
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22507897
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22507897
93DNA damage response, detection of DNA damage (GO:0042769)3.22158079
94cellular component biogenesis (GO:0044085)3.21881089
95GDP-mannose metabolic process (GO:0019673)3.20138566
96* translation (GO:0006412)3.19984558
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.14817415
98protein complex biogenesis (GO:0070271)3.14740949
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14301847
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13244713
101viral transcription (GO:0019083)3.10700448
102deoxyribonucleotide biosynthetic process (GO:0009263)3.09926300
103termination of RNA polymerase I transcription (GO:0006363)3.08469173
104translational termination (GO:0006415)3.06984952
105ribosomal small subunit biogenesis (GO:0042274)3.06107508
106transcription from RNA polymerase I promoter (GO:0006360)3.05012212
107mismatch repair (GO:0006298)3.04295131
108metaphase plate congression (GO:0051310)3.03772463
109* tRNA processing (GO:0008033)3.02991398
110SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02692107
111methionine biosynthetic process (GO:0009086)3.02542042
112intra-S DNA damage checkpoint (GO:0031573)3.02247828
113mitochondrial respiratory chain complex assembly (GO:0033108)3.01909024
114guanosine-containing compound biosynthetic process (GO:1901070)3.00795617
115peptidyl-arginine omega-N-methylation (GO:0035247)2.99996373
1162-deoxyribonucleotide biosynthetic process (GO:0009265)2.99603770
117deoxyribose phosphate biosynthetic process (GO:0046385)2.99603770
118mitotic sister chromatid segregation (GO:0000070)2.99251580
119cotranslational protein targeting to membrane (GO:0006613)2.99034495
120metallo-sulfur cluster assembly (GO:0031163)2.98375438
121iron-sulfur cluster assembly (GO:0016226)2.98375438
122* tRNA methylation (GO:0030488)2.97929078
123kinetochore assembly (GO:0051382)2.97340325
124IMP biosynthetic process (GO:0006188)2.97045783
125respiratory chain complex IV assembly (GO:0008535)2.96738860
126mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96331533
127transcription elongation from RNA polymerase I promoter (GO:0006362)2.95806799
128* ncRNA processing (GO:0034470)2.95792100
129DNA replication-independent nucleosome organization (GO:0034724)2.95410728
130negative regulation of protein ubiquitination (GO:0031397)2.95268366
131positive regulation of cell cycle arrest (GO:0071158)2.92888044
132histone arginine methylation (GO:0034969)2.89746519
133cell cycle G1/S phase transition (GO:0044843)2.88834580
134G1/S transition of mitotic cell cycle (GO:0000082)2.88834580
135establishment of chromosome localization (GO:0051303)2.85906257
136pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.81135413
137negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.78758186
138protein localization to kinetochore (GO:0034501)2.78140309
139regulation of translational fidelity (GO:0006450)2.78019053
140protein localization to chromosome, centromeric region (GO:0071459)2.76280931
141energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75722943
142ATP synthesis coupled proton transport (GO:0015986)2.75722943
143protein K11-linked ubiquitination (GO:0070979)2.74681007
144sister chromatid segregation (GO:0000819)2.72946646
145regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70626385
146activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.69349874
147antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.69022281
148pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.68465275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.24974411
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51610671
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.17144021
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.11550153
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.06965341
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.85206937
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.81771287
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.61860802
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.51205013
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.50901518
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15445990
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.14185563
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03425185
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87494107
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76429463
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74502061
17VDR_23849224_ChIP-Seq_CD4+_Human2.73306088
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68015970
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62885363
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55489766
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.43058057
22FOXP3_21729870_ChIP-Seq_TREG_Human2.42579583
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.42396223
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.40322299
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37083432
26DCP1A_22483619_ChIP-Seq_HELA_Human2.36269605
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.33705162
28XRN2_22483619_ChIP-Seq_HELA_Human2.23319883
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18561074
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16592169
31GABP_19822575_ChIP-Seq_HepG2_Human2.12517101
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11447395
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06550476
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05814495
35TTF2_22483619_ChIP-Seq_HELA_Human2.02410535
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99031290
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98121044
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93418679
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93220182
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90468422
41ELK1_19687146_ChIP-ChIP_HELA_Human1.88735929
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87929346
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82451531
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.80250283
45CIITA_25753668_ChIP-Seq_RAJI_Human1.73161560
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72015487
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66637721
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66603752
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56900902
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56052466
51ZNF263_19887448_ChIP-Seq_K562_Human1.52320282
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51453779
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49751419
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48856229
55IRF1_19129219_ChIP-ChIP_H3396_Human1.42765047
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.42164305
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.38366128
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36180855
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35832547
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35155305
61* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32043298
62KDM5A_27292631_Chip-Seq_BREAST_Human1.31839329
63* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29450717
64* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28170636
65MYC_18940864_ChIP-ChIP_HL60_Human1.26972513
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26501772
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26179052
68* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25333258
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.24478719
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23343865
71* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20186139
72AR_21909140_ChIP-Seq_LNCAP_Human1.19938695
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17193889
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15824835
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.15654094
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12401655
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11544973
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11082615
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.08610815
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04045701
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03406362
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03209450
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02878004
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01377587
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99366271
86TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98196655
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95884760
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94143433
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94128797
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93139245
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93076857
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92962760
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92675503
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92343623
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91397665
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89216847
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89080904
98TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88893996
99* SOX17_20123909_ChIP-Seq_XEN_Mouse0.86908821
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86739094
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86659079
102* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81126774
103TFEB_21752829_ChIP-Seq_HELA_Human0.80225340
104FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79206523
105SPI1_23547873_ChIP-Seq_NB4_Human0.77114870
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.69398928
107KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69359404
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.68589402
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.68547634
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68492698
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.63755368
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.63083360
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.62678630
114* YY1_22570637_ChIP-Seq_MALME-3M_Human0.61173718
115CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.60921412
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.60146215
117* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.58820106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.47655871
2MP0010094_abnormal_chromosome_stability3.82827842
3MP0008058_abnormal_DNA_repair3.60736959
4MP0003111_abnormal_nucleus_morphology3.44331761
5MP0001986_abnormal_taste_sensitivity3.37478263
6MP0004957_abnormal_blastocyst_morpholog3.33176823
7MP0008057_abnormal_DNA_replication3.30812231
8MP0006292_abnormal_olfactory_placode3.12938769
9MP0004147_increased_porphyrin_level2.95227139
10MP0003077_abnormal_cell_cycle2.86546923
11MP0005075_abnormal_melanosome_morpholog2.85647735
12MP0002132_abnormal_respiratory_system2.60776904
13MP0003718_maternal_effect2.59316538
14MP0003950_abnormal_plasma_membrane2.58217386
15MP0003806_abnormal_nucleotide_metabolis2.44270806
16MP0008932_abnormal_embryonic_tissue2.42189137
17MP0009379_abnormal_foot_pigmentation2.32909867
18MP0003656_abnormal_erythrocyte_physiolo2.29122252
19MP0008877_abnormal_DNA_methylation2.21702062
20MP0003786_premature_aging2.12743690
21MP0008438_abnormal_cutaneous_collagen2.11486024
22MP0001188_hyperpigmentation2.00506212
23MP0004233_abnormal_muscle_weight1.96613317
24MP0002396_abnormal_hematopoietic_system1.96447634
25MP0001764_abnormal_homeostasis1.96030047
26MP0008007_abnormal_cellular_replicative1.91193260
27MP0009697_abnormal_copulation1.87203448
28MP0002877_abnormal_melanocyte_morpholog1.86353430
29MP0000358_abnormal_cell_content/1.76627269
30MP0003566_abnormal_cell_adhesion1.76233308
31MP0006036_abnormal_mitochondrial_physio1.75941491
32MP0009333_abnormal_splenocyte_physiolog1.74375609
33MP0003186_abnormal_redox_activity1.74065574
34MP0005501_abnormal_skin_physiology1.72146044
35MP0000490_abnormal_crypts_of1.71310216
36MP0000749_muscle_degeneration1.69819174
37MP0002060_abnormal_skin_morphology1.68673452
38MP0001529_abnormal_vocalization1.68581448
39MP0002938_white_spotting1.60323609
40MP0008260_abnormal_autophagy1.59793288
41MP0004272_abnormal_basement_membrane1.59027073
42MP0000751_myopathy1.58586123
43MP0005623_abnormal_meninges_morphology1.57132158
44MP0000762_abnormal_tongue_morphology1.54445683
45MP0005257_abnormal_intraocular_pressure1.52219845
46MP0003221_abnormal_cardiomyocyte_apopto1.44566191
47MP0000015_abnormal_ear_pigmentation1.36752563
48MP0005671_abnormal_response_to1.36436096
49MP0003763_abnormal_thymus_physiology1.34241832
50MP0000750_abnormal_muscle_regeneration1.32144969
51MP0006035_abnormal_mitochondrial_morpho1.32010191
52MP0009053_abnormal_anal_canal1.31990963
53MP0002876_abnormal_thyroid_physiology1.31467807
54MP0004381_abnormal_hair_follicle1.30480038
55MP0003123_paternal_imprinting1.25173297
56MP0002160_abnormal_reproductive_system1.24270901
57MP0002234_abnormal_pharynx_morphology1.23715493
58MP0001661_extended_life_span1.23632126
59MP0005389_reproductive_system_phenotype1.22284830
60MP0004133_heterotaxia1.22186464
61MP0001216_abnormal_epidermal_layer1.19797168
62MP0000372_irregular_coat_pigmentation1.18423832
63MP0002095_abnormal_skin_pigmentation1.18171800
64MP0001243_abnormal_dermal_layer1.17994287
65MP0003890_abnormal_embryonic-extraembry1.17485723
66MP0005174_abnormal_tail_pigmentation1.16574703
67MP0002210_abnormal_sex_determination1.14512751
68MP0000579_abnormal_nail_morphology1.12691945
69MP0001919_abnormal_reproductive_system1.11282896
70MP0003136_yellow_coat_color1.09700008
71MP0000537_abnormal_urethra_morphology1.08979463
72MP0003385_abnormal_body_wall1.08218788
73MP0001849_ear_inflammation1.07684967
74MP0002796_impaired_skin_barrier1.07048664
75MP0001905_abnormal_dopamine_level1.06014442
76MP0001730_embryonic_growth_arrest1.05619717
77MP0005384_cellular_phenotype1.05268603
78MP0005646_abnormal_pituitary_gland1.04851669
79MP0001299_abnormal_eye_distance/1.04365481
80MP0003941_abnormal_skin_development1.04341652
81MP0003121_genomic_imprinting1.04300251
82MP0000467_abnormal_esophagus_morphology1.04205086
83MP0002163_abnormal_gland_morphology1.03382074
84MP0005023_abnormal_wound_healing1.02652062
85MP0010771_integument_phenotype0.99923547
86MP0000313_abnormal_cell_death0.99766832
87MP0003787_abnormal_imprinting0.99284853
88MP0003705_abnormal_hypodermis_morpholog0.99018035
89MP0005367_renal/urinary_system_phenotyp0.98445921
90MP0000516_abnormal_urinary_system0.98445921
91MP0001881_abnormal_mammary_gland0.98303401
92MP0002019_abnormal_tumor_incidence0.96948772
93MP0000350_abnormal_cell_proliferation0.95504099
94MP0000689_abnormal_spleen_morphology0.94570543
95MP0005084_abnormal_gallbladder_morpholo0.92526771
96MP0002398_abnormal_bone_marrow0.91242656
97MP0010234_abnormal_vibrissa_follicle0.90311224
98MP0001119_abnormal_female_reproductive0.90202957
99MP0005621_abnormal_cell_physiology0.89773038
100MP0002102_abnormal_ear_morphology0.89460891
101MP0004264_abnormal_extraembryonic_tissu0.88525705
102MP0001853_heart_inflammation0.88166140
103MP0001542_abnormal_bone_strength0.86504721
104MP0002722_abnormal_immune_system0.86244754
105MP0001145_abnormal_male_reproductive0.86063483
106MP0010352_gastrointestinal_tract_polyps0.85952377
107MP0002084_abnormal_developmental_patter0.85859209
108MP0003984_embryonic_growth_retardation0.85281102
109MP0003755_abnormal_palate_morphology0.85255481
110MP0005451_abnormal_body_composition0.83323561
111MP0000049_abnormal_middle_ear0.82911210
112MP0001545_abnormal_hematopoietic_system0.82836468
113MP0005397_hematopoietic_system_phenotyp0.82836468
114MP0001697_abnormal_embryo_size0.82805227
115MP0005645_abnormal_hypothalamus_physiol0.82450747
116MP0000858_altered_metastatic_potential0.81213527
117MP0002080_prenatal_lethality0.81062217
118MP0003195_calcinosis0.81006943
119MP0002177_abnormal_outer_ear0.80278653
120MP0002638_abnormal_pupillary_reflex0.80252615
121MP0001672_abnormal_embryogenesis/_devel0.79024397
122MP0005380_embryogenesis_phenotype0.79024397
123MP0002277_abnormal_respiratory_mucosa0.78860106
124MP0000653_abnormal_sex_gland0.78827644
125MP0002088_abnormal_embryonic_growth/wei0.78347426
126MP0009250_abnormal_appendicular_skeleto0.77592386
127MP0008995_early_reproductive_senescence0.77088527
128MP0002751_abnormal_autonomic_nervous0.76251304
129MP0000566_synostosis0.74983189
130MP0001727_abnormal_embryo_implantation0.74246152
131MP0000678_abnormal_parathyroid_gland0.73939187
132MP0003567_abnormal_fetal_cardiomyocyte0.73663798
133MP0002086_abnormal_extraembryonic_tissu0.73472195
134MP0000703_abnormal_thymus_morphology0.73191587
135MP0003315_abnormal_perineum_morphology0.72570535
136MP0000759_abnormal_skeletal_muscle0.72378985
137MP0002429_abnormal_blood_cell0.71400689
138MP0001929_abnormal_gametogenesis0.71010247
139MP0005408_hypopigmentation0.70692547
140MP0005394_taste/olfaction_phenotype0.70352533
141MP0005499_abnormal_olfactory_system0.70352533
142MP0005197_abnormal_uvea_morphology0.69285488
143MP0004197_abnormal_fetal_growth/weight/0.69272341
144MP0000627_abnormal_mammary_gland0.68726213
145MP0008004_abnormal_stomach_pH0.68281746
146MP0010030_abnormal_orbit_morphology0.68051469
147MP0005330_cardiomyopathy0.67635770
148MP0008789_abnormal_olfactory_epithelium0.67432333
149MP0005220_abnormal_exocrine_pancreas0.66828316
150MP0005171_absent_coat_pigmentation0.66353696
151MP0005670_abnormal_white_adipose0.66201467
152MP0001191_abnormal_skin_condition0.65375886
153MP0001186_pigmentation_phenotype0.65013497
154MP0005636_abnormal_mineral_homeostasis0.64737350
155MP0005193_abnormal_anterior_eye0.64418023
156MP0009931_abnormal_skin_appearance0.63605338
157MP0005395_other_phenotype0.63241944
158MP0005379_endocrine/exocrine_gland_phen0.63191508
159MP0003011_delayed_dark_adaptation0.62705921
160MP0002269_muscular_atrophy0.62198371
161MP0002085_abnormal_embryonic_tissue0.61602309
162MP0002148_abnormal_hypersensitivity_rea0.61149638
163MP0001293_anophthalmia0.59600718
164MP0000733_abnormal_muscle_development0.57703703
165MP0008873_increased_physiological_sensi0.57572980
166MP0002282_abnormal_trachea_morphology0.57047517

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.24835633
2Type I transferrin isoform profile (HP:0003642)3.89521339
3Abnormal number of erythroid precursors (HP:0012131)3.81474214
4Mitochondrial inheritance (HP:0001427)3.74314996
5Acute necrotizing encephalopathy (HP:0006965)3.66178322
6Abnormality of cells of the erythroid lineage (HP:0012130)3.65845424
7Abnormality of placental membranes (HP:0011409)3.64742228
8Amniotic constriction ring (HP:0009775)3.64742228
9Increased CSF lactate (HP:0002490)3.60437820
10Hepatocellular necrosis (HP:0001404)3.59530477
11Increased hepatocellular lipid droplets (HP:0006565)3.52042319
12Increased serum lactate (HP:0002151)3.46603559
133-Methylglutaconic aciduria (HP:0003535)3.41372905
14Reticulocytopenia (HP:0001896)3.40131410
15Birth length less than 3rd percentile (HP:0003561)3.37039915
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.34679924
17Premature rupture of membranes (HP:0001788)3.32804865
18Aplastic anemia (HP:0001915)3.30008742
19Cerebral hypomyelination (HP:0006808)3.29799260
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.29379511
21Abnormality of alanine metabolism (HP:0010916)3.29379511
22Hyperalaninemia (HP:0003348)3.29379511
23Lipid accumulation in hepatocytes (HP:0006561)3.28600540
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28564295
25Abnormal mitochondria in muscle tissue (HP:0008316)3.25300660
26Chromsome breakage (HP:0040012)3.23642393
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.15759881
28Abnormalities of placenta or umbilical cord (HP:0001194)3.07155971
29Hepatic necrosis (HP:0002605)3.06877027
30Entropion (HP:0000621)3.06719148
31Reduced subcutaneous adipose tissue (HP:0003758)3.06490010
32Acute encephalopathy (HP:0006846)3.04196927
33Abnormality of the umbilical cord (HP:0010881)3.03560297
34Microvesicular hepatic steatosis (HP:0001414)2.97928447
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.93714595
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.93714595
37Upper limb muscle weakness (HP:0003484)2.89968788
38Reduced antithrombin III activity (HP:0001976)2.87693187
39Renal Fanconi syndrome (HP:0001994)2.74916069
40Progressive macrocephaly (HP:0004481)2.72305688
41Abnormal glycosylation (HP:0012345)2.71471210
42Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71471210
43Abnormal protein N-linked glycosylation (HP:0012347)2.71471210
44Abnormal protein glycosylation (HP:0012346)2.71471210
45Lactic acidosis (HP:0003128)2.71099241
46Shoulder girdle muscle weakness (HP:0003547)2.69781818
47Exertional dyspnea (HP:0002875)2.59381907
48Onycholysis (HP:0001806)2.59235440
49Rough bone trabeculation (HP:0100670)2.56866723
50Abnormality of glycolysis (HP:0004366)2.53195230
51Increased serum pyruvate (HP:0003542)2.53195230
52Oral leukoplakia (HP:0002745)2.51388417
53Cholecystitis (HP:0001082)2.51298862
54Abnormal gallbladder physiology (HP:0012438)2.51298862
55Proximal placement of thumb (HP:0009623)2.48656696
56Pallor (HP:0000980)2.48260968
57Macrocytic anemia (HP:0001972)2.47890655
58Premature graying of hair (HP:0002216)2.46998874
59Abnormality of the preputium (HP:0100587)2.46467067
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43975517
61Abnormality of the ileum (HP:0001549)2.41419639
62Single umbilical artery (HP:0001195)2.41286809
63Abnormality of the fetal cardiovascular system (HP:0010948)2.41286809
64Abnormal umbilical cord blood vessels (HP:0011403)2.41286809
65Squamous cell carcinoma (HP:0002860)2.39351680
66Breast hypoplasia (HP:0003187)2.38166354
67Meckel diverticulum (HP:0002245)2.37981926
68Deviation of the thumb (HP:0009603)2.37745279
69Exercise intolerance (HP:0003546)2.36286956
70Vertebral compression fractures (HP:0002953)2.32617863
71Respiratory difficulties (HP:0002880)2.31441382
72Selective tooth agenesis (HP:0001592)2.28679576
73Respiratory failure (HP:0002878)2.28586186
74Sparse eyelashes (HP:0000653)2.28354931
75Short nail (HP:0001799)2.27763842
76Fragile nails (HP:0001808)2.24808879
77Patellar aplasia (HP:0006443)2.24282845
78Degeneration of anterior horn cells (HP:0002398)2.21225861
79Abnormality of the anterior horn cell (HP:0006802)2.21225861
80Type 2 muscle fiber atrophy (HP:0003554)2.18722185
81Duplicated collecting system (HP:0000081)2.17297410
82Multiple enchondromatosis (HP:0005701)2.16712895
83Progressive muscle weakness (HP:0003323)2.16565736
84Limb-girdle muscle atrophy (HP:0003797)2.16556183
85Carpal bone hypoplasia (HP:0001498)2.16127639
86Pelvic girdle muscle weakness (HP:0003749)2.15975050
87Nail dystrophy (HP:0008404)2.15893742
88Pancytopenia (HP:0001876)2.14968472
89Aplasia/hypoplasia of the uterus (HP:0008684)2.14837022
90Atrophic scars (HP:0001075)2.12769818
91Abnormality of the musculature of the pelvis (HP:0001469)2.12418277
92Abnormality of the hip-girdle musculature (HP:0001445)2.12418277
93Hypoplastic pelvis (HP:0008839)2.10290319
94IgM deficiency (HP:0002850)2.09596714
95Abnormality of the renal collecting system (HP:0004742)2.07845575
96Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07155015
97Bone marrow hypocellularity (HP:0005528)2.06128168
98Poikiloderma (HP:0001029)2.05954602
99Aplasia/Hypoplasia of the patella (HP:0006498)2.05300032
100CNS demyelination (HP:0007305)2.05266282
101Abnormality of renal resorption (HP:0011038)2.03496492
102Poor head control (HP:0002421)2.02924119
103Aplasia/Hypoplasia of the uvula (HP:0010293)2.01199351
104Abnormal lung lobation (HP:0002101)2.00557087
105Cerebral edema (HP:0002181)1.99571173
106Increased intramyocellular lipid droplets (HP:0012240)1.97355943
107Prominent metopic ridge (HP:0005487)1.96321372
108Muscle fiber atrophy (HP:0100295)1.95879297
109Abnormality of chromosome stability (HP:0003220)1.95507413
110Opisthotonus (HP:0002179)1.95388784
111Abnormality of the pons (HP:0007361)1.94233995
112Glucose intolerance (HP:0000833)1.94164150
113Postnatal microcephaly (HP:0005484)1.92896275
114Secondary amenorrhea (HP:0000869)1.92501178
115Optic disc pallor (HP:0000543)1.92022291
116Emotional lability (HP:0000712)1.90955596
117True hermaphroditism (HP:0010459)1.90639452
118Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89937665
119Hypokinesia (HP:0002375)1.89497179
120CNS hypomyelination (HP:0003429)1.86238459
121Abnormality of the distal phalanges of the toes (HP:0010182)1.85220288
122Megaloblastic anemia (HP:0001889)1.85031476
123Spastic diplegia (HP:0001264)1.84349124
124Horseshoe kidney (HP:0000085)1.83720267
125Ureteral duplication (HP:0000073)1.83237641
126Poor suck (HP:0002033)1.82827988
127Plantar hyperkeratosis (HP:0007556)1.82042514
128Hand muscle atrophy (HP:0009130)1.81950612
129Congenital, generalized hypertrichosis (HP:0004540)1.80965337
13011 pairs of ribs (HP:0000878)1.80844837
131Absent thumb (HP:0009777)1.80635614
132Abnormality of serum amino acid levels (HP:0003112)1.80448918
133Renal cortical cysts (HP:0000803)1.80091679
134Death in infancy (HP:0001522)1.79424375
135Redundant skin (HP:0001582)1.79233583
136Generalized amyotrophy (HP:0003700)1.78990615
137Abnormal trabecular bone morphology (HP:0100671)1.77037978
138Myelodysplasia (HP:0002863)1.76936370
139Triphalangeal thumb (HP:0001199)1.76246202
140Hypoplasia of the pons (HP:0012110)1.75855961
141Abnormality of pyrimidine metabolism (HP:0004353)1.75689005
142Methylmalonic aciduria (HP:0012120)1.75145818
143Petechiae (HP:0000967)1.74771146
144Impulsivity (HP:0100710)1.74648853
145Absent radius (HP:0003974)1.74595151
146Cellular immunodeficiency (HP:0005374)1.74560192
147Ragged-red muscle fibers (HP:0003200)1.74050295
148Trismus (HP:0000211)1.73368142
149Microglossia (HP:0000171)1.73367332
150Retinal dysplasia (HP:0007973)1.70989058
151Cutaneous melanoma (HP:0012056)1.70676467
152Premature ovarian failure (HP:0008209)1.69657177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.82744429
2BUB14.70797685
3VRK24.32753473
4EIF2AK13.99850569
5WEE13.01505082
6TESK12.89171240
7EIF2AK32.64949999
8SRPK12.62992677
9TLK12.29657492
10VRK12.09813927
11IRAK42.01826920
12NME22.01347974
13CDC71.90818840
14TSSK61.86717640
15MKNK11.83257559
16ZAK1.83089827
17MST1R1.77266466
18SCYL21.75834119
19DYRK31.65653866
20PAK41.60470551
21TESK21.60432738
22TRIM281.58763235
23CCNB11.55873288
24PIM21.55331672
25PLK41.55293815
26BRSK21.51557704
27MAP3K111.48150879
28SMG11.42982843
29NME11.40691928
30PLK11.39900559
31ARAF1.37262172
32AKT31.31436493
33WNK31.28371418
34ERBB41.27333122
35DYRK21.23419804
36PDK21.22356411
37MKNK21.22277843
38CDK191.19301073
39NLK1.18045214
40CDK71.16599523
41TEC1.16487429
42TTK1.16004036
43CDK81.14378165
44NEK21.14112556
45MAPKAPK51.13515122
46STK101.13326880
47ATR1.10847726
48NUAK11.08829399
49CSNK1A1L1.08220728
50ACVR1B1.07998974
51EIF2AK21.07793088
52AURKB1.06645345
53TNK21.04671897
54KDR1.02668501
55PLK31.00813938
56AURKA1.00497205
57ILK1.00173770
58IRAK20.97612120
59BRSK10.97082830
60CHEK20.96845630
61IRAK30.94241448
62YES10.92944192
63BCKDK0.91249044
64CASK0.90411079
65LMTK20.88069302
66CSNK1G20.87660773
67TAF10.86412652
68BRAF0.86057685
69EPHA20.85491356
70RPS6KB20.85466895
71MAP3K120.84956792
72MAP4K10.83000877
73MAP4K20.82495019
74PASK0.82017386
75ADRBK20.80500104
76MAP2K70.79254342
77ABL20.76761708
78MAP3K80.75613376
79CLK10.75389752
80CSNK2A10.73536655
81MET0.72182688
82IRAK10.72129396
83RPS6KA50.68954686
84MST40.68212528
85CHEK10.63986532
86PTK20.63827236
87DAPK30.62379302
88TXK0.60428922
89NEK10.59795809
90CSNK2A20.59130840
91DAPK10.59030159
92GRK10.58551838
93MAPK130.56790036
94TNIK0.56292718
95FLT30.56158137
96MUSK0.55925418
97BTK0.55900457
98STK38L0.54594303
99ERBB30.52329265
100CSNK1G30.51510494
101SIK30.51234482
102CDK30.51159998
103MOS0.51129501
104PRKCI0.49787297
105PBK0.49745281
106EPHB20.48536763
107PRPF4B0.48444751
108MYLK0.47530568
109CDK140.47305127
110TAOK20.46743223
111PINK10.45668012
112UHMK10.45459597
113BMPR1B0.45398696
114PIM10.45388944
115RAF10.44472026
116CDK180.40797173
117CDK20.40448621
118RPS6KA40.39901961
119BLK0.38771354
120CDK11A0.38530096
121ATM0.37975985
122CSNK1G10.37501693
123CDK90.37072737
124MAPKAPK30.36294801
125CDK150.36082304
126STK40.36076307
127LIMK10.35623459
128CAMKK20.35395542
129BCR0.34795975
130LYN0.34674471
131CDK10.34040203
132MAPK150.32661064
133PAK10.29849668
134GRK70.28868000
135MAPK110.28397587
136TTN0.28308754
137PAK20.28108067

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.24932383
2DNA replication_Homo sapiens_hsa030304.15631727
3Mismatch repair_Homo sapiens_hsa034304.11243318
4Ribosome_Homo sapiens_hsa030103.66800922
5RNA polymerase_Homo sapiens_hsa030203.56068208
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21155808
7Spliceosome_Homo sapiens_hsa030402.90880855
8Base excision repair_Homo sapiens_hsa034102.89546989
9Homologous recombination_Homo sapiens_hsa034402.86322247
10Pyrimidine metabolism_Homo sapiens_hsa002402.68196770
11Nucleotide excision repair_Homo sapiens_hsa034202.55999595
12Protein export_Homo sapiens_hsa030602.34183632
13One carbon pool by folate_Homo sapiens_hsa006702.33704237
14RNA transport_Homo sapiens_hsa030132.25213808
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17843407
16Oxidative phosphorylation_Homo sapiens_hsa001901.97676234
17Fanconi anemia pathway_Homo sapiens_hsa034601.87563657
18Parkinsons disease_Homo sapiens_hsa050121.82032797
19Non-homologous end-joining_Homo sapiens_hsa034501.81094103
20Basal transcription factors_Homo sapiens_hsa030221.75780550
21Cell cycle_Homo sapiens_hsa041101.67929564
22Folate biosynthesis_Homo sapiens_hsa007901.67611211
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61365982
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58419830
25RNA degradation_Homo sapiens_hsa030181.57747806
26Vitamin B6 metabolism_Homo sapiens_hsa007501.48129751
27Purine metabolism_Homo sapiens_hsa002301.45540060
28Huntingtons disease_Homo sapiens_hsa050161.38568786
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.32128795
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28906287
31Sulfur relay system_Homo sapiens_hsa041221.27323541
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19332678
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13420141
34mRNA surveillance pathway_Homo sapiens_hsa030151.10224017
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05782034
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.05130823
37Shigellosis_Homo sapiens_hsa051311.03456803
38Regulation of autophagy_Homo sapiens_hsa041401.02569061
39Drug metabolism - other enzymes_Homo sapiens_hsa009830.99936659
40Alzheimers disease_Homo sapiens_hsa050100.97058585
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96998855
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96273947
43p53 signaling pathway_Homo sapiens_hsa041150.93484304
44Selenocompound metabolism_Homo sapiens_hsa004500.88094215
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83977589
46Arachidonic acid metabolism_Homo sapiens_hsa005900.79594863
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78144505
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78117208
49Epstein-Barr virus infection_Homo sapiens_hsa051690.77779109
50Propanoate metabolism_Homo sapiens_hsa006400.76101749
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75248285
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73754735
53Metabolic pathways_Homo sapiens_hsa011000.72906373
54Primary immunodeficiency_Homo sapiens_hsa053400.70506405
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68664217
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68301610
57Glutathione metabolism_Homo sapiens_hsa004800.65863758
58Sulfur metabolism_Homo sapiens_hsa009200.64516408
59Fatty acid elongation_Homo sapiens_hsa000620.62083126
60Other glycan degradation_Homo sapiens_hsa005110.60552317
61Biosynthesis of amino acids_Homo sapiens_hsa012300.58512735
62Systemic lupus erythematosus_Homo sapiens_hsa053220.56873582
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.56192963
64Pentose phosphate pathway_Homo sapiens_hsa000300.55377462
65Herpes simplex infection_Homo sapiens_hsa051680.53755219
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53509141
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50360223
68Linoleic acid metabolism_Homo sapiens_hsa005910.47349863
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.47017672
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46787429
71Steroid biosynthesis_Homo sapiens_hsa001000.46421752
72Fructose and mannose metabolism_Homo sapiens_hsa000510.46373616
73N-Glycan biosynthesis_Homo sapiens_hsa005100.45507475
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45201796
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45003163
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43739247
77Salmonella infection_Homo sapiens_hsa051320.43516720
78Pyruvate metabolism_Homo sapiens_hsa006200.41935219
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38623794
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37182999
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36774205
82Carbon metabolism_Homo sapiens_hsa012000.36721045
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.36522370
84Small cell lung cancer_Homo sapiens_hsa052220.33867294
85Vitamin digestion and absorption_Homo sapiens_hsa049770.33187916
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32719292
87Bladder cancer_Homo sapiens_hsa052190.32366078
88Autoimmune thyroid disease_Homo sapiens_hsa053200.30912898
89Sphingolipid metabolism_Homo sapiens_hsa006000.30635355
90Apoptosis_Homo sapiens_hsa042100.29931669
91Allograft rejection_Homo sapiens_hsa053300.27626231
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27329518
93Arginine and proline metabolism_Homo sapiens_hsa003300.27213983
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26426453
95TGF-beta signaling pathway_Homo sapiens_hsa043500.25964804
96Peroxisome_Homo sapiens_hsa041460.24522041
97Thyroid cancer_Homo sapiens_hsa052160.24509300
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22998976
99HTLV-I infection_Homo sapiens_hsa051660.22185366
100Oocyte meiosis_Homo sapiens_hsa041140.20715267
101Collecting duct acid secretion_Homo sapiens_hsa049660.18641506
102Ether lipid metabolism_Homo sapiens_hsa005650.18482437
103Type I diabetes mellitus_Homo sapiens_hsa049400.17532856
104Hippo signaling pathway_Homo sapiens_hsa043900.16381677
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15918376
106Endocytosis_Homo sapiens_hsa041440.15585089
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15386883
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14616980
109Viral carcinogenesis_Homo sapiens_hsa052030.14312833
110Hematopoietic cell lineage_Homo sapiens_hsa046400.14046502
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12581831
112Measles_Homo sapiens_hsa051620.12547591
113Retinol metabolism_Homo sapiens_hsa008300.11894131
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11809638
115Fatty acid metabolism_Homo sapiens_hsa012120.10112789
116Cardiac muscle contraction_Homo sapiens_hsa042600.10081609
117Legionellosis_Homo sapiens_hsa051340.10060553
118Graft-versus-host disease_Homo sapiens_hsa053320.09850836
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.09515513
120Vibrio cholerae infection_Homo sapiens_hsa051100.08499661
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08430163
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.08009720
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07618050
124Alcoholism_Homo sapiens_hsa050340.07444905
125Galactose metabolism_Homo sapiens_hsa000520.06428923

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