FTSJ3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.01758810
2nuclear pore complex assembly (GO:0051292)4.91065854
3folic acid-containing compound biosynthetic process (GO:0009396)4.70707780
4DNA unwinding involved in DNA replication (GO:0006268)4.68812079
5nucleobase biosynthetic process (GO:0046112)4.62156642
6IMP biosynthetic process (GO:0006188)4.59707698
7protein localization to kinetochore (GO:0034501)4.54379447
8DNA replication initiation (GO:0006270)4.40385601
9establishment of integrated proviral latency (GO:0075713)4.31371814
10ribosome assembly (GO:0042255)4.29952743
11maturation of SSU-rRNA (GO:0030490)4.24258607
12mitotic nuclear envelope disassembly (GO:0007077)4.23967971
13purine nucleobase biosynthetic process (GO:0009113)4.18973176
14mitotic metaphase plate congression (GO:0007080)4.18353322
15DNA strand elongation involved in DNA replication (GO:0006271)4.14570546
16spliceosomal tri-snRNP complex assembly (GO:0000244)4.11032656
17formation of translation preinitiation complex (GO:0001731)4.09963856
18DNA replication-dependent nucleosome organization (GO:0034723)4.07385376
19DNA replication-dependent nucleosome assembly (GO:0006335)4.07385376
20IMP metabolic process (GO:0046040)4.01034985
21ribosome biogenesis (GO:0042254)3.96241518
22DNA strand elongation (GO:0022616)3.94208999
23nuclear envelope disassembly (GO:0051081)3.91473180
24membrane disassembly (GO:0030397)3.91473180
25peptidyl-arginine omega-N-methylation (GO:0035247)3.87838744
26pore complex assembly (GO:0046931)3.80487154
27COPI coating of Golgi vesicle (GO:0048205)3.78785440
28Golgi transport vesicle coating (GO:0048200)3.78785440
29protein complex localization (GO:0031503)3.78183964
30protein localization to chromosome, centromeric region (GO:0071459)3.74345043
31ribosomal large subunit biogenesis (GO:0042273)3.73408882
32telomere maintenance via semi-conservative replication (GO:0032201)3.72291007
33DNA replication checkpoint (GO:0000076)3.70962068
34DNA duplex unwinding (GO:0032508)3.69603425
35DNA geometric change (GO:0032392)3.68648488
36regulation of posttranscriptional gene silencing (GO:0060147)3.68532878
37regulation of gene silencing by miRNA (GO:0060964)3.68532878
38regulation of gene silencing by RNA (GO:0060966)3.68532878
39ribonucleoprotein complex biogenesis (GO:0022613)3.64915081
40metaphase plate congression (GO:0051310)3.61241668
41negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.53904999
42regulation of spindle organization (GO:0090224)3.52797472
43kinetochore organization (GO:0051383)3.48661981
44mitotic sister chromatid segregation (GO:0000070)3.46238403
45cellular protein complex localization (GO:0034629)3.42147458
46telomere maintenance via recombination (GO:0000722)3.41342317
47establishment of viral latency (GO:0019043)3.40424188
48chromatin remodeling at centromere (GO:0031055)3.38438307
49mitotic recombination (GO:0006312)3.37940429
50positive regulation of chromosome segregation (GO:0051984)3.34754016
51histone arginine methylation (GO:0034969)3.34607519
52proline biosynthetic process (GO:0006561)3.34407062
53mitotic chromosome condensation (GO:0007076)3.32772222
54* rRNA processing (GO:0006364)3.32652908
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.31761606
56regulation of histone H3-K9 methylation (GO:0051570)3.30242526
57CENP-A containing nucleosome assembly (GO:0034080)3.29054901
58ribosomal small subunit assembly (GO:0000028)3.27764468
59sister chromatid segregation (GO:0000819)3.27394365
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.27189002
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27189002
62DNA topological change (GO:0006265)3.26366204
63telomere maintenance via telomere lengthening (GO:0010833)3.25922919
64* rRNA metabolic process (GO:0016072)3.23420126
65regulation of mitotic spindle organization (GO:0060236)3.23397954
66regulation of helicase activity (GO:0051095)3.22708351
67establishment of chromosome localization (GO:0051303)3.22636645
68peptidyl-arginine methylation (GO:0018216)3.22423585
69peptidyl-arginine N-methylation (GO:0035246)3.22423585
70mitotic sister chromatid cohesion (GO:0007064)3.22073641
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21006241
72DNA replication-independent nucleosome organization (GO:0034724)3.17061092
73DNA replication-independent nucleosome assembly (GO:0006336)3.17061092
74heterochromatin organization (GO:0070828)3.16644701
75regulation of centrosome cycle (GO:0046605)3.14632058
76nucleobase-containing small molecule interconversion (GO:0015949)3.14497764
77folic acid metabolic process (GO:0046655)3.14488209
78protein K6-linked ubiquitination (GO:0085020)3.11486043
79regulation of translational fidelity (GO:0006450)3.10626510
80attachment of spindle microtubules to kinetochore (GO:0008608)3.09037079
81chromosome condensation (GO:0030261)3.06838053
82kinetochore assembly (GO:0051382)3.06672178
83translational initiation (GO:0006413)3.04565624
84nuclear envelope organization (GO:0006998)3.02973043
85pentose-phosphate shunt (GO:0006098)3.02397322
86negative regulation of mRNA processing (GO:0050686)3.02204399
87viral mRNA export from host cell nucleus (GO:0046784)3.01852770
88tetrahydrofolate metabolic process (GO:0046653)3.01695722
89ribosomal small subunit biogenesis (GO:0042274)3.00331188
90spliceosomal snRNP assembly (GO:0000387)2.99486919
91spindle checkpoint (GO:0031577)2.99455250
92translational termination (GO:0006415)2.99382091
93negative regulation of mRNA metabolic process (GO:1903312)2.99078665
94negative regulation of chromosome segregation (GO:0051985)2.98906188
95viral transcription (GO:0019083)2.98556248
96negative regulation of histone methylation (GO:0031061)2.97736341
97DNA conformation change (GO:0071103)2.96896363
98nucleotide-excision repair, DNA gap filling (GO:0006297)2.96759966
99chromatin assembly or disassembly (GO:0006333)2.96557174
100regulation of chromosome segregation (GO:0051983)2.94499380
101spindle assembly checkpoint (GO:0071173)2.93356963
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.93089234
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93089234
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93089234
105negative regulation of sister chromatid segregation (GO:0033046)2.93089234
106mitotic spindle checkpoint (GO:0071174)2.92102350
107chromatin assembly (GO:0031497)2.92040676
108regulation of nuclear cell cycle DNA replication (GO:0033262)2.91628633
109regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90353192
110NADPH regeneration (GO:0006740)2.90303199
111rRNA transcription (GO:0009303)2.90136311
112histone exchange (GO:0043486)2.89733129
113mitotic spindle assembly checkpoint (GO:0007094)2.89263105
114pre-miRNA processing (GO:0031054)2.85743535
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85698929
116regulation of translational termination (GO:0006449)2.85279111
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83788633
118L-serine metabolic process (GO:0006563)2.83653504
119tRNA aminoacylation for protein translation (GO:0006418)2.83450352
120regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83228547
121maturation of 5.8S rRNA (GO:0000460)2.83089412
122regulation of centriole replication (GO:0046599)2.82848030
123negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82798290
124regulation of telomere maintenance via telomerase (GO:0032210)2.81966838
125positive regulation of mitotic sister chromatid separation (GO:1901970)2.81175682
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.81175682
127negative regulation of RNA splicing (GO:0033119)2.79440871
128mRNA splicing, via spliceosome (GO:0000398)2.77074549
129RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.77074549
130amino acid activation (GO:0043038)2.76947133
131tRNA aminoacylation (GO:0043039)2.76947133
132negative regulation of ligase activity (GO:0051352)2.75565156
133negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75565156
134regulation of RNA export from nucleus (GO:0046831)2.75402561
135regulation of mammary gland epithelial cell proliferation (GO:0033599)2.75344882
136regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.72121383
137RNA splicing, via transesterification reactions (GO:0000375)2.71237631
138non-recombinational repair (GO:0000726)2.69784266
139double-strand break repair via nonhomologous end joining (GO:0006303)2.69784266
140DNA ligation (GO:0006266)2.66719376
141protein export from nucleus (GO:0006611)2.64154299
142histone H2B ubiquitination (GO:0033523)2.62368901
143positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.61665041
144DNA packaging (GO:0006323)2.61191962
145protein maturation by protein folding (GO:0022417)2.61001234
146mitochondrial DNA metabolic process (GO:0032042)2.58102809
147RNA stabilization (GO:0043489)2.56752495
148mRNA stabilization (GO:0048255)2.56752495
149chromosome segregation (GO:0007059)2.55882098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.12947701
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.40082596
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.37801997
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.78988170
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.29449425
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19738282
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18480861
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86873269
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61610910
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55646755
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.53371567
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.46432792
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39106983
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29910776
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28195251
16AR_21909140_ChIP-Seq_LNCAP_Human2.23099745
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.22378074
18* GABP_17652178_ChIP-ChIP_JURKAT_Human2.21210305
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19616230
20XRN2_22483619_ChIP-Seq_HELA_Human2.19229505
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12080552
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.08065516
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02566678
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01872576
25VDR_23849224_ChIP-Seq_CD4+_Human1.93263737
26ZNF263_19887448_ChIP-Seq_K562_Human1.93052472
27* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92860286
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90078467
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87037623
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83296396
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.83001633
32FOXP3_21729870_ChIP-Seq_TREG_Human1.82849026
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80950656
34MYC_22102868_ChIP-Seq_BL_Human1.74351832
35TTF2_22483619_ChIP-Seq_HELA_Human1.69542710
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66795033
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66193234
38DCP1A_22483619_ChIP-Seq_HELA_Human1.65837103
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.65559588
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63595229
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61215390
42CIITA_25753668_ChIP-Seq_RAJI_Human1.58684941
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55615800
44* GABP_19822575_ChIP-Seq_HepG2_Human1.55379566
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55153856
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53844079
47ELK1_19687146_ChIP-ChIP_HELA_Human1.52890978
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46556538
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45939253
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.44665414
51KDM5A_27292631_Chip-Seq_BREAST_Human1.44398112
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44209111
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43398768
54KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43398768
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43398768
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.39150263
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38004371
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33573599
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33528270
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33015811
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31169349
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.30939564
63CLOCK_20551151_ChIP-Seq_293T_Human1.30016673
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28337007
65VDR_21846776_ChIP-Seq_THP-1_Human1.27920152
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26326998
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25847309
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22737997
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.22039750
70RACK7_27058665_Chip-Seq_MCF-7_Human1.20365672
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18104959
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17751015
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.17582422
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17345466
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16783376
76* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15250091
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14005527
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13618511
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13411310
80TFEB_21752829_ChIP-Seq_HELA_Human1.12179791
81* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12163812
82* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11731222
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11301804
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10633887
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10391505
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09932376
87* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08136043
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08122508
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07471752
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07316441
91NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07003554
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06654645
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05191152
94ATF3_27146783_Chip-Seq_COLON_Human1.03677420
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03556415
96CHD1_26751641_Chip-Seq_LNCaP_Human1.02777582
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00976045
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00864384
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00643997
100TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98585291
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98581779
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97264418
103* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96259822
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95145630
105SRF_21415370_ChIP-Seq_HL-1_Mouse0.94533436
106CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93801441
107* SOX17_20123909_ChIP-Seq_XEN_Mouse0.93601727
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93166072
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93119894
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92802326
111RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92546740
112MYC_18940864_ChIP-ChIP_HL60_Human0.92372839
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91933105
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91735805
115* NANOG_21062744_ChIP-ChIP_HESCs_Human0.90834661
116CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88843572
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88766435
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88390293
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88375044
120* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87459803
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85903589
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85062240
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83038595
124SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81306754
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81074195
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80410347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.07945095
2MP0003111_abnormal_nucleus_morphology4.56362283
3MP0010094_abnormal_chromosome_stability4.37241667
4MP0004957_abnormal_blastocyst_morpholog4.15560622
5MP0008057_abnormal_DNA_replication3.87010468
6MP0003077_abnormal_cell_cycle3.71169216
7MP0008058_abnormal_DNA_repair3.22656454
8MP0010352_gastrointestinal_tract_polyps2.69119548
9MP0008007_abnormal_cellular_replicative2.62789669
10MP0008932_abnormal_embryonic_tissue2.56425224
11MP0001730_embryonic_growth_arrest2.52670384
12MP0004233_abnormal_muscle_weight2.23839072
13MP0000350_abnormal_cell_proliferation2.23270311
14MP0010307_abnormal_tumor_latency2.18188498
15MP0005451_abnormal_body_composition2.10061925
16MP0002396_abnormal_hematopoietic_system2.06207763
17MP0003806_abnormal_nucleotide_metabolis2.03908184
18MP0003123_paternal_imprinting2.02583996
19MP0003786_premature_aging1.93892639
20MP0005380_embryogenesis_phenotype1.91945631
21MP0001672_abnormal_embryogenesis/_devel1.91945631
22MP0001697_abnormal_embryo_size1.74699229
23MP0002796_impaired_skin_barrier1.73626688
24MP0008877_abnormal_DNA_methylation1.70223846
25MP0004197_abnormal_fetal_growth/weight/1.69524244
26MP0003984_embryonic_growth_retardation1.69491347
27MP0003890_abnormal_embryonic-extraembry1.68653691
28MP0002085_abnormal_embryonic_tissue1.68643217
29MP0002088_abnormal_embryonic_growth/wei1.67010205
30MP0002084_abnormal_developmental_patter1.65363102
31MP0003941_abnormal_skin_development1.60907772
32MP0002080_prenatal_lethality1.60698441
33MP0003705_abnormal_hypodermis_morpholog1.60288221
34MP0005076_abnormal_cell_differentiation1.59688942
35MP0002086_abnormal_extraembryonic_tissu1.58470436
36MP0008438_abnormal_cutaneous_collagen1.54662674
37MP0008260_abnormal_autophagy1.53579440
38MP0003718_maternal_effect1.53186254
39MP0000490_abnormal_crypts_of1.42410886
40MP0002060_abnormal_skin_morphology1.39408079
41MP0010030_abnormal_orbit_morphology1.33344850
42MP0000313_abnormal_cell_death1.32552184
43MP0003567_abnormal_fetal_cardiomyocyte1.30991023
44MP0002019_abnormal_tumor_incidence1.28884110
45MP0004272_abnormal_basement_membrane1.23915435
46MP0001293_anophthalmia1.23372065
47MP0005257_abnormal_intraocular_pressure1.22867229
48MP0003221_abnormal_cardiomyocyte_apopto1.20890471
49MP0001661_extended_life_span1.18969123
50MP0004133_heterotaxia1.16907392
51MP0003566_abnormal_cell_adhesion1.16632226
52MP0005023_abnormal_wound_healing1.15125442
53MP0000537_abnormal_urethra_morphology1.10587441
54MP0004808_abnormal_hematopoietic_stem1.10455152
55MP0000579_abnormal_nail_morphology1.10223135
56MP0003119_abnormal_digestive_system1.07747611
57MP0009053_abnormal_anal_canal1.07531701
58MP0002111_abnormal_tail_morphology1.07386862
59MP0009672_abnormal_birth_weight1.05897750
60MP0003453_abnormal_keratinocyte_physiol1.03706378
61MP0005623_abnormal_meninges_morphology1.03392849
62MP0003121_genomic_imprinting1.02445005
63MP0002210_abnormal_sex_determination1.01706166
64MP0009333_abnormal_splenocyte_physiolog1.01250282
65MP0003937_abnormal_limbs/digits/tail_de1.00683590
66MP0001216_abnormal_epidermal_layer0.98950539
67MP0006035_abnormal_mitochondrial_morpho0.97869567
68MP0000762_abnormal_tongue_morphology0.96618752
69MP0005058_abnormal_lysosome_morphology0.95819927
70MP0002089_abnormal_postnatal_growth/wei0.95373031
71MP0000703_abnormal_thymus_morphology0.94636730
72MP0003763_abnormal_thymus_physiology0.94551927
73MP0009703_decreased_birth_body0.89963876
74MP0001145_abnormal_male_reproductive0.89738661
75MP0000678_abnormal_parathyroid_gland0.87679758
76MP0000428_abnormal_craniofacial_morphol0.86306275
77MP0001849_ear_inflammation0.86034507
78MP0005501_abnormal_skin_physiology0.83419227
79MP0002697_abnormal_eye_size0.83201437
80MP0001881_abnormal_mammary_gland0.82371583
81MP0009697_abnormal_copulation0.82138206
82MP0003315_abnormal_perineum_morphology0.81742359
83MP0005621_abnormal_cell_physiology0.81562024
84MP0002092_abnormal_eye_morphology0.81369816
85MP0000858_altered_metastatic_potential0.81062478
86MP0001915_intracranial_hemorrhage0.80557498
87MP0006292_abnormal_olfactory_placode0.78905371
88MP0005384_cellular_phenotype0.78581666
89MP0000003_abnormal_adipose_tissue0.77964632
90MP0002722_abnormal_immune_system0.77881975
91MP0003942_abnormal_urinary_system0.77516574
92MP0001346_abnormal_lacrimal_gland0.77152087
93MP0005330_cardiomyopathy0.76495697
94MP0000733_abnormal_muscle_development0.76279481
95MP0000432_abnormal_head_morphology0.75949318
96MP0000467_abnormal_esophagus_morphology0.75305492
97MP0000653_abnormal_sex_gland0.74413593
98MP0001286_abnormal_eye_development0.74234910
99MP0000747_muscle_weakness0.73865577
100MP0010630_abnormal_cardiac_muscle0.73523356
101MP0001929_abnormal_gametogenesis0.73509747
102MP0004858_abnormal_nervous_system0.73162290
103MP0001348_abnormal_lacrimal_gland0.72371755
104MP0004264_abnormal_extraembryonic_tissu0.71993149
105MP0000377_abnormal_hair_follicle0.71764847
106MP0000689_abnormal_spleen_morphology0.70820054
107MP0010771_integument_phenotype0.70366856
108MP0002269_muscular_atrophy0.70010919
109MP0002653_abnormal_ependyma_morphology0.69593344
110MP0002398_abnormal_bone_marrow0.68362482
111MP0000477_abnormal_intestine_morphology0.67923162
112MP0000358_abnormal_cell_content/0.67748029
113MP0002160_abnormal_reproductive_system0.66726872
114MP0002098_abnormal_vibrissa_morphology0.66548952
115MP0010234_abnormal_vibrissa_follicle0.66429860
116MP0009931_abnormal_skin_appearance0.66125767
117MP0001119_abnormal_female_reproductive0.63200856
118MP0002877_abnormal_melanocyte_morpholog0.62611723
119MP0003935_abnormal_craniofacial_develop0.59557044
120MP0005389_reproductive_system_phenotype0.59125709
121MP0001853_heart_inflammation0.58419661
122MP0001727_abnormal_embryo_implantation0.56520605
123MP0001243_abnormal_dermal_layer0.55606023
124MP0004185_abnormal_adipocyte_glucose0.55103327
125MP0005395_other_phenotype0.54415102
126MP0000750_abnormal_muscle_regeneration0.53650777
127MP0002925_abnormal_cardiovascular_devel0.52998851
128MP0001545_abnormal_hematopoietic_system0.52908269
129MP0005397_hematopoietic_system_phenotyp0.52908269
130MP0002429_abnormal_blood_cell0.52365197
131MP0003936_abnormal_reproductive_system0.52089019
132MP0000371_diluted_coat_color0.51279701
133MP0000627_abnormal_mammary_gland0.50353710
134MP0002075_abnormal_coat/hair_pigmentati0.49208932
135MP0003115_abnormal_respiratory_system0.48778569

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.50991288
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.41938664
3Birth length less than 3rd percentile (HP:0003561)4.24861326
4Ependymoma (HP:0002888)3.92975463
5Reticulocytopenia (HP:0001896)3.86647674
6Selective tooth agenesis (HP:0001592)3.58384140
7Medulloblastoma (HP:0002885)3.55559218
8Progressive muscle weakness (HP:0003323)3.42795323
9Hyperacusis (HP:0010780)3.38838982
10Breast hypoplasia (HP:0003187)3.26906641
11Abnormality of chromosome stability (HP:0003220)3.14602359
12Colon cancer (HP:0003003)3.11364611
13Meckel diverticulum (HP:0002245)3.04996996
14Abnormality of the preputium (HP:0100587)2.98048859
15Absent radius (HP:0003974)2.92348528
16Premature rupture of membranes (HP:0001788)2.87547389
17Microvesicular hepatic steatosis (HP:0001414)2.87365848
18Patellar aplasia (HP:0006443)2.86574546
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.86414490
20Abnormality of the ileum (HP:0001549)2.86146040
21Impulsivity (HP:0100710)2.83768251
22Absent thumb (HP:0009777)2.83420337
23Oral leukoplakia (HP:0002745)2.83160029
24Rhabdomyosarcoma (HP:0002859)2.77548741
25Abnormality of the umbilical cord (HP:0010881)2.73154659
26Astrocytoma (HP:0009592)2.71910192
27Abnormality of the astrocytes (HP:0100707)2.71910192
28Progressive external ophthalmoplegia (HP:0000590)2.70254911
29Aplasia/Hypoplasia of the patella (HP:0006498)2.69904851
30Aplasia involving forearm bones (HP:0009822)2.68261645
31Absent forearm bone (HP:0003953)2.68261645
32Agnosia (HP:0010524)2.67478888
33Abnormality of the labia minora (HP:0012880)2.66020963
34Carpal bone hypoplasia (HP:0001498)2.65467355
35Asymmetry of the thorax (HP:0001555)2.64681351
36Glioma (HP:0009733)2.63665178
37Duplicated collecting system (HP:0000081)2.61243504
38Squamous cell carcinoma (HP:0002860)2.58206836
39Rough bone trabeculation (HP:0100670)2.56832218
40Abnormality of pyrimidine metabolism (HP:0004353)2.55083095
41Neoplasm of the pancreas (HP:0002894)2.53762578
4211 pairs of ribs (HP:0000878)2.50417411
43Abnormality of glycolysis (HP:0004366)2.49901789
44Abnormality of the anterior horn cell (HP:0006802)2.48394221
45Degeneration of anterior horn cells (HP:0002398)2.48394221
46Abnormal number of incisors (HP:0011064)2.47552378
47Short nail (HP:0001799)2.47061284
48Ectopic kidney (HP:0000086)2.46206462
49Trismus (HP:0000211)2.44860691
50Missing ribs (HP:0000921)2.43568763
51Abnormality of cells of the erythroid lineage (HP:0012130)2.43394140
52Basal cell carcinoma (HP:0002671)2.43228231
53Myelodysplasia (HP:0002863)2.41274113
54Small intestinal stenosis (HP:0012848)2.41100718
55Duodenal stenosis (HP:0100867)2.41100718
56Insomnia (HP:0100785)2.39625448
57Back pain (HP:0003418)2.36868753
58Ulnar bowing (HP:0003031)2.35341476
59Deviation of the thumb (HP:0009603)2.33891152
60Neoplasm of the oral cavity (HP:0100649)2.31490178
61Proximal placement of thumb (HP:0009623)2.30174150
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29996766
63Achilles tendon contracture (HP:0001771)2.29854809
64Supernumerary spleens (HP:0009799)2.27093066
65Sloping forehead (HP:0000340)2.26806721
66Abnormality of the distal phalanges of the toes (HP:0010182)2.25841523
67Microglossia (HP:0000171)2.25126732
68Biliary tract neoplasm (HP:0100574)2.24498801
69Aplasia/hypoplasia of the humerus (HP:0006507)2.24131009
70Increased serum pyruvate (HP:0003542)2.22016104
71Horseshoe kidney (HP:0000085)2.21515897
72Ragged-red muscle fibers (HP:0003200)2.18954341
73Abnormality of the fetal cardiovascular system (HP:0010948)2.17286938
74Abnormal umbilical cord blood vessels (HP:0011403)2.17286938
75Single umbilical artery (HP:0001195)2.17286938
76Premature graying of hair (HP:0002216)2.15274648
77Abnormality of the renal collecting system (HP:0004742)2.13282054
78Bone marrow hypocellularity (HP:0005528)2.12319321
79Macrocytic anemia (HP:0001972)2.11721653
80Abnormal number of erythroid precursors (HP:0012131)2.11645565
81Deep philtrum (HP:0002002)2.11487919
82Neoplasm of striated muscle (HP:0009728)2.11399212
83Entropion (HP:0000621)2.10783368
84Abnormal gallbladder physiology (HP:0012438)2.10304561
85Cholecystitis (HP:0001082)2.10304561
86Short thumb (HP:0009778)2.09919909
87Abnormality of DNA repair (HP:0003254)2.07827670
88Cerebral hypomyelination (HP:0006808)2.07784229
89Abnormalities of placenta or umbilical cord (HP:0001194)2.07546928
90Abnormality of the duodenum (HP:0002246)2.06656301
91Spastic diplegia (HP:0001264)2.05989089
92Septate vagina (HP:0001153)2.05466095
93Abnormality of the carotid arteries (HP:0005344)2.05217769
94Overriding aorta (HP:0002623)2.04776305
95Ureteral duplication (HP:0000073)2.04323253
96Tracheoesophageal fistula (HP:0002575)2.01583353
97Abnormality of the Achilles tendon (HP:0005109)2.01073122
98Shoulder girdle muscle weakness (HP:0003547)2.00517103
99Increased nuchal translucency (HP:0010880)2.00478563
100Secondary amenorrhea (HP:0000869)2.00254935
101Spinal cord lesions (HP:0100561)2.00141496
102Syringomyelia (HP:0003396)2.00141496
103Prominent nose (HP:0000448)1.99343492
104Abnormal lung lobation (HP:0002101)1.98211454
105Long palpebral fissure (HP:0000637)1.97501074
106Cafe-au-lait spot (HP:0000957)1.97486127
107Pallor (HP:0000980)1.96303687
108Protrusio acetabuli (HP:0003179)1.94685924
109Premature ovarian failure (HP:0008209)1.94657399
110Short humerus (HP:0005792)1.94580928
111Nephroblastoma (Wilms tumor) (HP:0002667)1.93458394
112Sparse lateral eyebrow (HP:0005338)1.92821414
113Atresia of the external auditory canal (HP:0000413)1.91496419
114Multiple enchondromatosis (HP:0005701)1.90948616
115Amaurosis fugax (HP:0100576)1.90551900
116Cellular immunodeficiency (HP:0005374)1.90468460
117Vertebral compression fractures (HP:0002953)1.90246547
118Abnormal trabecular bone morphology (HP:0100671)1.90123638
119Osteolytic defects of the hand bones (HP:0009699)1.88780603
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.88780603
121Testicular atrophy (HP:0000029)1.88623281
122Abnormality of the calcaneus (HP:0008364)1.87443693
123Broad distal phalanx of finger (HP:0009836)1.85503171
124Slender long bone (HP:0003100)1.85384750
125Increased connective tissue (HP:0009025)1.84733625
126Micronodular cirrhosis (HP:0001413)1.84022540
127Anal stenosis (HP:0002025)1.82415733
128Termporal pattern (HP:0011008)1.81452611
129Insidious onset (HP:0003587)1.81452611
130Embryonal renal neoplasm (HP:0011794)1.80338839
131Orthostatic hypotension (HP:0001278)1.80121701
132High pitched voice (HP:0001620)1.79993464
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79171417
134Pelvic girdle muscle weakness (HP:0003749)1.78951914
135Aplasia/Hypoplasia of the sternum (HP:0006714)1.78174520
136Triphalangeal thumb (HP:0001199)1.77920151
137High anterior hairline (HP:0009890)1.77372526
138Overlapping toe (HP:0001845)1.76276926
139Generalized amyotrophy (HP:0003700)1.76169756
140Neoplasm of the colon (HP:0100273)1.75465215
141Abdominal situs inversus (HP:0003363)1.75440035
142Abnormality of abdominal situs (HP:0011620)1.75440035
143Flat acetabular roof (HP:0003180)1.75379754
144Spinal cord compression (HP:0002176)1.75336362
145Abnormal biliary tract morphology (HP:0012440)1.74774833
146Supernumerary bones of the axial skeleton (HP:0009144)1.74427301
147Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72184195
148Elfin facies (HP:0004428)1.71714626
149Facial cleft (HP:0002006)1.71051017
150Distal lower limb muscle weakness (HP:0009053)1.70010557
151Breech presentation (HP:0001623)1.69637465
152Ankle contracture (HP:0006466)1.69020724
153Spinal muscular atrophy (HP:0007269)1.68730349
154Gastrointestinal carcinoma (HP:0002672)1.68432415
155Malignant gastrointestinal tract tumors (HP:0006749)1.68432415
156Cortical dysplasia (HP:0002539)1.67845197
157Lymphoma (HP:0002665)1.67788308
158Natal tooth (HP:0000695)1.67594457
159Asplenia (HP:0001746)1.67527360
160Renal duplication (HP:0000075)1.67399252
161Sparse eyelashes (HP:0000653)1.67392923
162Microretrognathia (HP:0000308)1.67367476
163Progressive hearing impairment (HP:0001730)1.66895421
164Disproportionate tall stature (HP:0001519)1.65961146
165Patellar dislocation (HP:0002999)1.63980091
166Broad face (HP:0000283)1.61493052
167Pseudobulbar signs (HP:0002200)1.60423424
168Glossoptosis (HP:0000162)1.60346427
169Unilateral renal agenesis (HP:0000122)1.59872637
170Nonimmune hydrops fetalis (HP:0001790)1.59385405
171Choanal atresia (HP:0000453)1.58476755
172Abnormality of the phalanges of the hallux (HP:0010057)1.58114542
173Poikiloderma (HP:0001029)1.57728001
174Elbow flexion contracture (HP:0002987)1.57244668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.79191232
2BUB13.78730251
3WEE13.64928477
4SMG13.52293841
5TRIB32.95327462
6CDK122.95170418
7TTK2.83153988
8SRPK12.80254556
9TSSK62.79684001
10EPHA22.66087758
11NEK22.62545440
12EIF2AK12.62461803
13VRK22.34595250
14PBK2.32540797
15RPS6KB22.21311452
16EEF2K2.13047297
17NEK12.12175945
18PASK2.12042716
19PLK11.98072331
20PLK41.92805081
21ZAK1.91094674
22ICK1.85129958
23SIK11.83039258
24MKNK11.79111711
25ATR1.76243369
26AURKB1.73584942
27CDK71.72441099
28TLK11.69343238
29PLK31.67812313
30NME21.65665162
31STK101.55995587
32EIF2AK31.54672078
33MAP3K81.52455657
34BRSK21.51077987
35CHEK11.45928614
36MST1R1.44619677
37ACVR1B1.44056706
38BRD41.42514749
39ALK1.40834749
40CDK41.39321829
41CHEK21.37415912
42PNCK1.34942438
43TAF11.27112687
44MST41.26931646
45MKNK21.25935979
46VRK11.24405978
47RPS6KA41.21687586
48TESK21.20361174
49PKN21.20142345
50TGFBR11.14707401
51AURKA1.13250307
52PDK21.08581327
53STK41.07377581
54ATM1.06998302
55NME11.05693313
56DYRK31.04878485
57PDGFRA1.04828726
58FGFR41.04538529
59SCYL21.03187198
60PRPF4B1.02692911
61CDK21.00001007
62PIM10.96974707
63STK160.94035509
64MAP3K100.90203562
65FLT30.89251483
66CDK80.87127729
67MTOR0.84890311
68LATS10.84099282
69EIF2AK20.83197746
70STK38L0.82143949
71PAK40.79613480
72PRKCI0.78220818
73CDK60.78039704
74TTN0.77021679
75CSNK2A20.76736220
76CDK10.72982467
77MAP4K10.71239946
78ERBB40.71234161
79CDK90.70978169
80PTK20.70444429
81BRSK10.70293552
82PAK20.70086522
83STK30.68906484
84IRAK30.66734229
85MELK0.66243515
86CSNK1E0.65589086
87MAP2K30.64037359
88LRRK20.63594610
89ARAF0.60258354
90ILK0.55483982
91CSNK2A10.55312063
92RPS6KA50.53667169
93PTK60.53418290
94FGFR10.52026256
95MAPKAPK30.51669668
96PRKDC0.51566591
97MAP3K30.50763536
98CSNK1D0.49310863
99PAK10.49125230
100NEK60.47971569
101ERN10.46859052
102AKT20.43447136
103MUSK0.43131750
104LATS20.42261301
105SIK30.41788975
106MAP3K90.41756578
107MAPK110.41559521
108BRAF0.40277493
109MET0.38314966
110MAPK140.37286482
111TESK10.37059593
112DAPK10.36321070
113CHUK0.34150110
114MARK30.33861327
115PIM20.32545160
116CDK11A0.30968948
117AKT10.28716557
118MAP2K20.28292035
119MAPK10.27907174
120TAOK20.27182374
121KDR0.27119126
122GSK3B0.23826631
123BMX0.23749359
124AKT30.22517589
125CLK10.21132391
126RPS6KB10.20946341
127GRK60.19042262
128BTK0.18258227
129RPS6KA10.17619086
130PDK30.16930875

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.31037039
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.15677987
3Mismatch repair_Homo sapiens_hsa034303.98592392
4One carbon pool by folate_Homo sapiens_hsa006703.53921747
5RNA transport_Homo sapiens_hsa030133.30512354
6Spliceosome_Homo sapiens_hsa030403.23854467
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.12247550
8RNA polymerase_Homo sapiens_hsa030202.81310951
9Homologous recombination_Homo sapiens_hsa034402.79851574
10Nucleotide excision repair_Homo sapiens_hsa034202.74999959
11Base excision repair_Homo sapiens_hsa034102.67798672
12Ribosome_Homo sapiens_hsa030102.66126395
13Proteasome_Homo sapiens_hsa030502.56142332
14Cell cycle_Homo sapiens_hsa041102.50395744
15Fanconi anemia pathway_Homo sapiens_hsa034602.33279272
16Non-homologous end-joining_Homo sapiens_hsa034502.23120064
17Pyrimidine metabolism_Homo sapiens_hsa002402.12371729
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.05318690
19mRNA surveillance pathway_Homo sapiens_hsa030151.91717116
20RNA degradation_Homo sapiens_hsa030181.89347812
21Basal transcription factors_Homo sapiens_hsa030221.68782588
22p53 signaling pathway_Homo sapiens_hsa041151.64501634
23Systemic lupus erythematosus_Homo sapiens_hsa053221.61519441
24Selenocompound metabolism_Homo sapiens_hsa004501.29141280
25Epstein-Barr virus infection_Homo sapiens_hsa051691.17862204
26Biosynthesis of amino acids_Homo sapiens_hsa012301.15895756
27Viral carcinogenesis_Homo sapiens_hsa052031.14698498
28Antigen processing and presentation_Homo sapiens_hsa046121.08993908
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.08154002
30Purine metabolism_Homo sapiens_hsa002301.06159944
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.01558466
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98870156
33Pyruvate metabolism_Homo sapiens_hsa006200.93136566
34Drug metabolism - other enzymes_Homo sapiens_hsa009830.89181760
35Herpes simplex infection_Homo sapiens_hsa051680.87094698
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86571031
37Fatty acid elongation_Homo sapiens_hsa000620.84192459
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80398808
39MicroRNAs in cancer_Homo sapiens_hsa052060.79107086
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78987117
41Vitamin B6 metabolism_Homo sapiens_hsa007500.78332405
42Pentose phosphate pathway_Homo sapiens_hsa000300.77800048
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77053058
44HTLV-I infection_Homo sapiens_hsa051660.76957692
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76581950
46Pancreatic cancer_Homo sapiens_hsa052120.75622824
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74060642
48Non-small cell lung cancer_Homo sapiens_hsa052230.73776666
49Folate biosynthesis_Homo sapiens_hsa007900.72474052
50Small cell lung cancer_Homo sapiens_hsa052220.70354773
51Sulfur relay system_Homo sapiens_hsa041220.70013540
52Steroid biosynthesis_Homo sapiens_hsa001000.66294771
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65845048
54Endometrial cancer_Homo sapiens_hsa052130.64403670
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62167774
56Lysine degradation_Homo sapiens_hsa003100.61421697
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.60416497
58Oocyte meiosis_Homo sapiens_hsa041140.59793371
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55421177
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55032201
61TGF-beta signaling pathway_Homo sapiens_hsa043500.54701725
62Carbon metabolism_Homo sapiens_hsa012000.54566986
63Hippo signaling pathway_Homo sapiens_hsa043900.53905417
64Basal cell carcinoma_Homo sapiens_hsa052170.53645526
65Shigellosis_Homo sapiens_hsa051310.53225063
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50517337
67Primary immunodeficiency_Homo sapiens_hsa053400.50256089
68Other glycan degradation_Homo sapiens_hsa005110.49997040
69Thyroid cancer_Homo sapiens_hsa052160.49754804
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48524222
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47411778
72Legionellosis_Homo sapiens_hsa051340.47270627
73Apoptosis_Homo sapiens_hsa042100.46768758
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41543251
75Arginine biosynthesis_Homo sapiens_hsa002200.41392305
76Alcoholism_Homo sapiens_hsa050340.41360127
77Adherens junction_Homo sapiens_hsa045200.40898729
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40243107
79Prion diseases_Homo sapiens_hsa050200.39644260
80Insulin signaling pathway_Homo sapiens_hsa049100.39186728
81Glutathione metabolism_Homo sapiens_hsa004800.38698890
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38075836
83Notch signaling pathway_Homo sapiens_hsa043300.37627095
84Fructose and mannose metabolism_Homo sapiens_hsa000510.37083675
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36534849
86Measles_Homo sapiens_hsa051620.35148427
87Bladder cancer_Homo sapiens_hsa052190.35089769
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33168831
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.32820207
90Chronic myeloid leukemia_Homo sapiens_hsa052200.32095882
91Phenylalanine metabolism_Homo sapiens_hsa003600.31393838
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30390751
93Glioma_Homo sapiens_hsa052140.29216739
94Renal cell carcinoma_Homo sapiens_hsa052110.28974629
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28812051
96AMPK signaling pathway_Homo sapiens_hsa041520.28753562
97Vibrio cholerae infection_Homo sapiens_hsa051100.28170580
98Arginine and proline metabolism_Homo sapiens_hsa003300.26644995
99Viral myocarditis_Homo sapiens_hsa054160.26527037
100Colorectal cancer_Homo sapiens_hsa052100.26486171
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26393635
102Pathways in cancer_Homo sapiens_hsa052000.24112132
103HIF-1 signaling pathway_Homo sapiens_hsa040660.22816774
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22675511
105Tight junction_Homo sapiens_hsa045300.22507118
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21253606
107Hepatitis B_Homo sapiens_hsa051610.20934384
108Prostate cancer_Homo sapiens_hsa052150.20895359
109Hedgehog signaling pathway_Homo sapiens_hsa043400.20864629
110Acute myeloid leukemia_Homo sapiens_hsa052210.18394465
111Influenza A_Homo sapiens_hsa051640.18268580
112N-Glycan biosynthesis_Homo sapiens_hsa005100.17085812
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16466239
114Hematopoietic cell lineage_Homo sapiens_hsa046400.15369690
115Proteoglycans in cancer_Homo sapiens_hsa052050.14995355
116Vitamin digestion and absorption_Homo sapiens_hsa049770.14052795
117mTOR signaling pathway_Homo sapiens_hsa041500.13633890
118Galactose metabolism_Homo sapiens_hsa000520.12956499
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12748690
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12614711
121Metabolic pathways_Homo sapiens_hsa011000.12610409
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10928227
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10694965
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10643049

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