FUBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.68827644
2nuclear pore complex assembly (GO:0051292)4.63702381
3nuclear pore organization (GO:0006999)4.50127044
4mitotic sister chromatid cohesion (GO:0007064)4.39420766
5kinetochore organization (GO:0051383)4.11478006
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.07818115
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.03297099
8double-strand break repair via nonhomologous end joining (GO:0006303)3.92361100
9non-recombinational repair (GO:0000726)3.92361100
10establishment of integrated proviral latency (GO:0075713)3.89563125
11negative regulation of RNA splicing (GO:0033119)3.84177189
12DNA ligation (GO:0006266)3.80772570
13pre-miRNA processing (GO:0031054)3.70802781
14negative regulation of mRNA processing (GO:0050686)3.66105810
15DNA topological change (GO:0006265)3.63878550
16protein localization to kinetochore (GO:0034501)3.60744158
17mRNA splice site selection (GO:0006376)3.58843983
18kinetochore assembly (GO:0051382)3.56079983
19regulation of DNA endoreduplication (GO:0032875)3.54991872
20pore complex assembly (GO:0046931)3.53056629
21sister chromatid segregation (GO:0000819)3.47531879
22mitotic chromosome condensation (GO:0007076)3.46106394
23DNA replication-dependent nucleosome assembly (GO:0006335)3.42817710
24DNA replication-dependent nucleosome organization (GO:0034723)3.42817710
25DNA duplex unwinding (GO:0032508)3.35283367
26DNA geometric change (GO:0032392)3.33998744
27DNA replication-independent nucleosome organization (GO:0034724)3.31592683
28DNA replication-independent nucleosome assembly (GO:0006336)3.31592683
29regulation of RNA export from nucleus (GO:0046831)3.28459202
30chromatin remodeling at centromere (GO:0031055)3.27688944
31mitotic nuclear envelope disassembly (GO:0007077)3.26317030
32mitotic metaphase plate congression (GO:0007080)3.25350645
33CENP-A containing nucleosome assembly (GO:0034080)3.23777506
34negative regulation of mRNA metabolic process (GO:1903312)3.19358722
35DNA double-strand break processing (GO:0000729)3.18368283
36regulation of histone H3-K9 methylation (GO:0051570)3.16804026
37DNA replication initiation (GO:0006270)3.14820813
38negative regulation of histone methylation (GO:0031061)3.13693988
39DNA replication checkpoint (GO:0000076)3.11861489
40ATP-dependent chromatin remodeling (GO:0043044)3.11826626
41alternative mRNA splicing, via spliceosome (GO:0000380)3.11434952
42establishment of chromosome localization (GO:0051303)3.11139937
43metaphase plate congression (GO:0051310)3.10871696
44protein localization to chromosome, centromeric region (GO:0071459)3.10655072
45V(D)J recombination (GO:0033151)3.10044763
46dosage compensation (GO:0007549)3.09670186
47histone H2A acetylation (GO:0043968)3.08930239
48regulation of helicase activity (GO:0051095)3.08918596
49paraxial mesoderm development (GO:0048339)3.07550302
50regulation of centriole replication (GO:0046599)3.06353294
51spindle assembly checkpoint (GO:0071173)3.05296810
52DNA strand elongation involved in DNA replication (GO:0006271)3.04951540
53membrane disassembly (GO:0030397)3.04564834
54nuclear envelope disassembly (GO:0051081)3.04564834
55RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.03052306
56mRNA splicing, via spliceosome (GO:0000398)3.03052306
57mitotic sister chromatid segregation (GO:0000070)3.02586871
58regulation of DNA damage checkpoint (GO:2000001)3.01359640
59RNA splicing, via transesterification reactions (GO:0000375)3.00468792
60telomere maintenance via recombination (GO:0000722)3.00015979
61replication fork processing (GO:0031297)2.98653108
62somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98340881
63somatic hypermutation of immunoglobulin genes (GO:0016446)2.98340881
64spindle checkpoint (GO:0031577)2.98250326
65negative regulation of mitotic sister chromatid separation (GO:2000816)2.98246316
66negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98246316
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98246316
68negative regulation of sister chromatid segregation (GO:0033046)2.98246316
69regulation of nuclear cell cycle DNA replication (GO:0033262)2.97925038
70ribosome assembly (GO:0042255)2.97651391
71mitotic spindle assembly checkpoint (GO:0007094)2.97136135
72positive regulation of cell cycle checkpoint (GO:1901978)2.96674394
73regulation of sister chromatid cohesion (GO:0007063)2.95882172
74negative regulation of chromosome segregation (GO:0051985)2.95705073
75negative regulation of DNA recombination (GO:0045910)2.95667851
76DNA strand elongation (GO:0022616)2.95457155
77regulation of mRNA splicing, via spliceosome (GO:0048024)2.95329113
78chromatin assembly or disassembly (GO:0006333)2.95051458
79heterochromatin organization (GO:0070828)2.94846854
80mitotic recombination (GO:0006312)2.94816159
81negative regulation of DNA-dependent DNA replication (GO:2000104)2.94548204
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94383575
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94383575
84positive regulation of mitotic sister chromatid separation (GO:1901970)2.94383575
85chromosome segregation (GO:0007059)2.94373102
86histone exchange (GO:0043486)2.93852782
87termination of RNA polymerase II transcription (GO:0006369)2.92797605
88mitotic spindle checkpoint (GO:0071174)2.91796942
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90897020
90regulation of mitotic spindle checkpoint (GO:1903504)2.90897020
91regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90839349
92histone H3-K9 methylation (GO:0051567)2.89141487
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88254945
94protein localization to chromosome (GO:0034502)2.87856038
95RNA export from nucleus (GO:0006405)2.87644337
96DNA conformation change (GO:0071103)2.87306952
97chromatin assembly (GO:0031497)2.84145484
98attachment of spindle microtubules to kinetochore (GO:0008608)2.83906730
99mRNA export from nucleus (GO:0006406)2.83830161
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83287085
101IMP biosynthetic process (GO:0006188)2.82210452
102regulation of mitotic sister chromatid separation (GO:0010965)2.82017891
103regulation of mitotic sister chromatid segregation (GO:0033047)2.82017891
104regulation of sister chromatid segregation (GO:0033045)2.82017891
105mRNA transport (GO:0051028)2.80445794
106regulation of chromosome segregation (GO:0051983)2.80395600
107meiotic chromosome segregation (GO:0045132)2.78635183
108nucleosome disassembly (GO:0006337)2.76268412
109protein-DNA complex disassembly (GO:0032986)2.76268412
110translesion synthesis (GO:0019985)2.75756163
111intra-S DNA damage checkpoint (GO:0031573)2.75415943
112regulation of spindle organization (GO:0090224)2.73972392
113telomere maintenance via semi-conservative replication (GO:0032201)2.73424158
114regulation of centrosome cycle (GO:0046605)2.73121943
115positive regulation of histone H3-K4 methylation (GO:0051571)2.72702987
116regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70488463
117microtubule depolymerization (GO:0007019)2.68573443
118peptidyl-lysine trimethylation (GO:0018023)2.68463439
119spliceosomal tri-snRNP complex assembly (GO:0000244)2.68111208
120sister chromatid cohesion (GO:0007062)2.66330861
121positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.65954904
122positive regulation of chromosome segregation (GO:0051984)2.63939604
123mismatch repair (GO:0006298)2.63680594
124regulation of centrosome duplication (GO:0010824)2.63133127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.30189086
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.70919131
3* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.37990485
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.36270496
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35171465
6* MYC_18555785_ChIP-Seq_MESCs_Mouse3.33905492
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.30869870
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.19399940
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.17373225
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.66424719
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43463791
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40060148
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.39451612
14* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33912875
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26457159
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18244068
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08978199
18CIITA_25753668_ChIP-Seq_RAJI_Human2.06477633
19E2F7_22180533_ChIP-Seq_HELA_Human10.7100012
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97924597
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.94599389
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93199104
23AR_21909140_ChIP-Seq_LNCAP_Human1.86721686
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.84391024
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84136106
26* XRN2_22483619_ChIP-Seq_HELA_Human1.79428050
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72718311
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72215244
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69256948
30ELK1_19687146_ChIP-ChIP_HELA_Human1.67321532
31* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.61596553
32* TTF2_22483619_ChIP-Seq_HELA_Human1.61297314
33* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60856924
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59866774
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57992174
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56749409
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55689079
38MYC_22102868_ChIP-Seq_BL_Human1.54385292
39VDR_23849224_ChIP-Seq_CD4+_Human1.51421437
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50283916
41TAF15_26573619_Chip-Seq_HEK293_Human1.49817493
42* EWS_26573619_Chip-Seq_HEK293_Human1.49470808
43IGF1R_20145208_ChIP-Seq_DFB_Human1.46037655
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45804992
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.45455440
46FOXP3_21729870_ChIP-Seq_TREG_Human1.41991319
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41407030
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.37239812
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33857417
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33779286
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32889453
52* FUS_26573619_Chip-Seq_HEK293_Human1.31596750
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30321870
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29592757
55SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27698594
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.25611047
57* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24064601
58ZNF274_21170338_ChIP-Seq_K562_Hela1.22646697
59* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22235918
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21393144
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18947856
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17913058
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16483169
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16305412
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11821658
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11140009
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11099005
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10939767
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10884432
70* KDM5A_27292631_Chip-Seq_BREAST_Human1.10444834
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.09832889
72PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08051279
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07371087
74* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07313985
75MYC_18940864_ChIP-ChIP_HL60_Human1.06909102
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04148711
77GABP_19822575_ChIP-Seq_HepG2_Human1.01160995
78NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99706383
79E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99235112
80DCP1A_22483619_ChIP-Seq_HELA_Human0.99195702
81* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97920017
82NANOG_16153702_ChIP-ChIP_HESCs_Human0.97730542
83* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96592692
84NANOG_21062744_ChIP-ChIP_HESCs_Human0.96432726
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93277590
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92740312
87* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91720956
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91707008
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90750007
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89825127
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89795992
92* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89152807
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.85878223
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85167459
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84715148
96P300_19829295_ChIP-Seq_ESCs_Human0.84701693
97TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82960692
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80986129
99FLI1_27457419_Chip-Seq_LIVER_Mouse0.80972944
100ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79477067
101* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77910932
102IRF1_19129219_ChIP-ChIP_H3396_Human0.77460735
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.77226884
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76863526
105* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.76620206
106SOX9_26525672_Chip-Seq_HEART_Mouse0.75237820
107* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74753662
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74529963
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74129425
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73984272
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.72406266
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.70028488
113* CHD1_26751641_Chip-Seq_LNCaP_Human0.68824589
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.68445232
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.68036132
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.67749640
117ZFP281_27345836_Chip-Seq_ESCs_Mouse0.67231036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.56994699
2MP0003111_abnormal_nucleus_morphology3.22977172
3MP0008057_abnormal_DNA_replication3.22251690
4MP0003121_genomic_imprinting3.07378436
5MP0003693_abnormal_embryo_hatching2.95511951
6MP0003077_abnormal_cell_cycle2.84422409
7MP0008058_abnormal_DNA_repair2.66700038
8MP0003123_paternal_imprinting2.66228211
9MP0004957_abnormal_blastocyst_morpholog2.46553896
10MP0008877_abnormal_DNA_methylation2.43143400
11MP0003787_abnormal_imprinting2.26595483
12MP0002009_preneoplasia2.22641558
13MP0000569_abnormal_digit_pigmentation2.22341677
14MP0003122_maternal_imprinting2.21902757
15MP0008007_abnormal_cellular_replicative2.12210412
16MP0003890_abnormal_embryonic-extraembry2.08769014
17MP0000537_abnormal_urethra_morphology1.97123677
18MP0006292_abnormal_olfactory_placode1.96002541
19MP0010030_abnormal_orbit_morphology1.95510661
20MP0009697_abnormal_copulation1.84043806
21MP0008932_abnormal_embryonic_tissue1.82682818
22MP0001293_anophthalmia1.82436021
23MP0002938_white_spotting1.79811421
24MP0000350_abnormal_cell_proliferation1.72381820
25MP0003937_abnormal_limbs/digits/tail_de1.69826497
26MP0009053_abnormal_anal_canal1.62954639
27MP0002084_abnormal_developmental_patter1.60738840
28MP0002085_abnormal_embryonic_tissue1.59309114
29MP0001730_embryonic_growth_arrest1.57442196
30MP0004197_abnormal_fetal_growth/weight/1.55845001
31MP0000566_synostosis1.54332068
32MP0002396_abnormal_hematopoietic_system1.52009628
33MP0003567_abnormal_fetal_cardiomyocyte1.50304602
34MP0005380_embryogenesis_phenotype1.48344850
35MP0001672_abnormal_embryogenesis/_devel1.48344850
36MP0003941_abnormal_skin_development1.46194917
37MP0005076_abnormal_cell_differentiation1.43627501
38MP0000049_abnormal_middle_ear1.43097808
39MP0003385_abnormal_body_wall1.41581652
40MP0001697_abnormal_embryo_size1.36448633
41MP0003119_abnormal_digestive_system1.35616370
42MP0003984_embryonic_growth_retardation1.32398240
43MP0001286_abnormal_eye_development1.32362344
44MP0003935_abnormal_craniofacial_develop1.31571554
45MP0002088_abnormal_embryonic_growth/wei1.31025482
46MP0003718_maternal_effect1.30252469
47MP0003221_abnormal_cardiomyocyte_apopto1.30187391
48MP0004808_abnormal_hematopoietic_stem1.29154428
49MP0008789_abnormal_olfactory_epithelium1.29110818
50MP0003861_abnormal_nervous_system1.28018760
51MP0010352_gastrointestinal_tract_polyps1.27317959
52MP0003315_abnormal_perineum_morphology1.23459213
53MP0003786_premature_aging1.21978940
54MP0009703_decreased_birth_body1.21010878
55MP0003755_abnormal_palate_morphology1.18872330
56MP0000428_abnormal_craniofacial_morphol1.18558135
57MP0003115_abnormal_respiratory_system1.18477199
58MP0003942_abnormal_urinary_system1.17748743
59MP0002653_abnormal_ependyma_morphology1.16612367
60MP0010307_abnormal_tumor_latency1.15723541
61MP0002086_abnormal_extraembryonic_tissu1.15006553
62MP0002080_prenatal_lethality1.14760024
63MP0002697_abnormal_eye_size1.14528127
64MP0009672_abnormal_birth_weight1.12885218
65MP0000432_abnormal_head_morphology1.11531268
66MP0002102_abnormal_ear_morphology1.10975556
67MP0002751_abnormal_autonomic_nervous1.09277526
68MP0002092_abnormal_eye_morphology1.08232950
69MP0000516_abnormal_urinary_system1.08095402
70MP0005367_renal/urinary_system_phenotyp1.08095402
71MP0005499_abnormal_olfactory_system1.07820605
72MP0005394_taste/olfaction_phenotype1.07820605
73MP0003938_abnormal_ear_development1.07237625
74MP0001529_abnormal_vocalization1.04910998
75MP0002116_abnormal_craniofacial_bone1.04909964
76MP0002233_abnormal_nose_morphology1.03988981
77MP0002111_abnormal_tail_morphology1.03980870
78MP0001188_hyperpigmentation1.03717522
79MP0000778_abnormal_nervous_system1.02235052
80MP0002249_abnormal_larynx_morphology0.99993368
81MP0002210_abnormal_sex_determination0.99403706
82MP0004133_heterotaxia0.97243611
83MP0002932_abnormal_joint_morphology0.95536354
84MP0000647_abnormal_sebaceous_gland0.94997367
85MP0001299_abnormal_eye_distance/0.94254939
86MP0001929_abnormal_gametogenesis0.93768694
87MP0000631_abnormal_neuroendocrine_gland0.92945561
88MP0002114_abnormal_axial_skeleton0.92807506
89MP0003136_yellow_coat_color0.91608814
90MP0008995_early_reproductive_senescence0.91262462
91MP0002177_abnormal_outer_ear0.91035626
92MP0005187_abnormal_penis_morphology0.90798211
93MP0002081_perinatal_lethality0.90645703
94MP0000313_abnormal_cell_death0.90394253
95MP0009250_abnormal_appendicular_skeleto0.89728505
96MP0000703_abnormal_thymus_morphology0.88436202
97MP0010234_abnormal_vibrissa_follicle0.86025023
98MP0002095_abnormal_skin_pigmentation0.84062973
99MP0005409_darkened_coat_color0.83921785
100MP0005174_abnormal_tail_pigmentation0.82463280
101MP0005253_abnormal_eye_physiology0.82273314
102MP0002109_abnormal_limb_morphology0.82190736
103MP0005220_abnormal_exocrine_pancreas0.81889471
104MP0000490_abnormal_crypts_of0.80500892
105MP0005645_abnormal_hypothalamus_physiol0.79877670
106MP0000733_abnormal_muscle_development0.79820156
107MP0010678_abnormal_skin_adnexa0.79399342
108MP0005391_vision/eye_phenotype0.79391252
109MP0001145_abnormal_male_reproductive0.78453991
110MP0002282_abnormal_trachea_morphology0.78389288
111MP0006072_abnormal_retinal_apoptosis0.78316854
112MP0005248_abnormal_Harderian_gland0.77549361
113MP0002925_abnormal_cardiovascular_devel0.77112877
114MP0000653_abnormal_sex_gland0.75832818
115MP0002234_abnormal_pharynx_morphology0.75699459
116MP0000383_abnormal_hair_follicle0.75605520
117MP0000372_irregular_coat_pigmentation0.74980729
118MP0001177_atelectasis0.72543266
119MP0003943_abnormal_hepatobiliary_system0.72413704
120MP0001346_abnormal_lacrimal_gland0.69929722
121MP0002184_abnormal_innervation0.67761853
122MP0002019_abnormal_tumor_incidence0.66360446

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.59219707
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.59219707
3Chromsome breakage (HP:0040012)3.28043438
4Volvulus (HP:0002580)3.25577565
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24685827
6Cortical dysplasia (HP:0002539)3.15569249
7Medulloblastoma (HP:0002885)3.09510452
8Neoplasm of the adrenal cortex (HP:0100641)2.97702306
9Abnormal number of incisors (HP:0011064)2.78568714
10Colon cancer (HP:0003003)2.74278578
11Ectopic kidney (HP:0000086)2.72550424
12Increased nuchal translucency (HP:0010880)2.69246001
13Abnormality of the labia minora (HP:0012880)2.66570810
14Ependymoma (HP:0002888)2.57232266
15Abnormality of the 4th metacarpal (HP:0010012)2.47974961
16Hepatoblastoma (HP:0002884)2.47387436
17Proximal placement of thumb (HP:0009623)2.42973077
18Meckel diverticulum (HP:0002245)2.39849547
19Aplasia/Hypoplasia of the sternum (HP:0006714)2.37699813
20Renal duplication (HP:0000075)2.35427621
21Nephroblastoma (Wilms tumor) (HP:0002667)2.34200116
22Abnormal lung lobation (HP:0002101)2.34029166
23Trigonocephaly (HP:0000243)2.33599229
24Overlapping toe (HP:0001845)2.33079712
25Patellar aplasia (HP:0006443)2.31890829
26Midline defect of the nose (HP:0004122)2.31354189
27Deviation of the thumb (HP:0009603)2.31101397
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.30178069
29Abnormality of chromosome stability (HP:0003220)2.29904921
30Abnormality of the ileum (HP:0001549)2.29448842
31Long eyelashes (HP:0000527)2.25212125
32Abnormality of the fingertips (HP:0001211)2.23971566
33Embryonal renal neoplasm (HP:0011794)2.20758234
34Supernumerary ribs (HP:0005815)2.20257549
35Abnormality of the astrocytes (HP:0100707)2.18772000
36Astrocytoma (HP:0009592)2.18772000
37Aplasia/Hypoplasia of the patella (HP:0006498)2.17646987
38Birth length less than 3rd percentile (HP:0003561)2.16345520
39Supernumerary bones of the axial skeleton (HP:0009144)2.13954030
40Small intestinal stenosis (HP:0012848)2.10068603
41Duodenal stenosis (HP:0100867)2.10068603
42Glioma (HP:0009733)2.09163181
43Neoplasm of the oral cavity (HP:0100649)2.07827482
44Skull defect (HP:0001362)2.05107005
45Selective tooth agenesis (HP:0001592)2.03395753
46High anterior hairline (HP:0009890)2.03156858
47Anophthalmia (HP:0000528)2.02118223
48Abnormality of the preputium (HP:0100587)2.01050629
49Oligodactyly (HP:0012165)2.00428466
50Deep philtrum (HP:0002002)1.99747485
51Abnormality of the carotid arteries (HP:0005344)1.99245658
52Intestinal atresia (HP:0011100)1.99165116
53Atresia of the external auditory canal (HP:0000413)1.96779329
54Obsessive-compulsive behavior (HP:0000722)1.96668055
55Supernumerary spleens (HP:0009799)1.96004099
56Reticulocytopenia (HP:0001896)1.95643093
57Anal stenosis (HP:0002025)1.95059291
58Neoplasm of the colon (HP:0100273)1.91617346
59Absent radius (HP:0003974)1.91384617
60Embryonal neoplasm (HP:0002898)1.89450327
61Optic nerve coloboma (HP:0000588)1.88462377
62Triphalangeal thumb (HP:0001199)1.88049782
63Esophageal atresia (HP:0002032)1.87011805
64Abnormality of the duodenum (HP:0002246)1.85839937
65Rhabdomyosarcoma (HP:0002859)1.85783294
66Thyroid carcinoma (HP:0002890)1.85008694
67Abnormality of the incisor (HP:0000676)1.84064950
68Cafe-au-lait spot (HP:0000957)1.83509938
69Absent forearm bone (HP:0003953)1.83293243
70Aplasia involving forearm bones (HP:0009822)1.83293243
71Abnormality of the septum pellucidum (HP:0007375)1.82757850
72Neoplasm of striated muscle (HP:0009728)1.82331486
73Partial agenesis of the corpus callosum (HP:0001338)1.81960043
74Myelodysplasia (HP:0002863)1.81520346
75Facial cleft (HP:0002006)1.81471185
76Spastic diplegia (HP:0001264)1.81367361
77Abnormality of abdominal situs (HP:0011620)1.80787563
78Abdominal situs inversus (HP:0003363)1.80787563
79Oligodactyly (hands) (HP:0001180)1.80419831
80Sandal gap (HP:0001852)1.80314115
81Renal hypoplasia (HP:0000089)1.79685127
82Abnormality of DNA repair (HP:0003254)1.77420817
83Acute myeloid leukemia (HP:0004808)1.77275900
84Renovascular hypertension (HP:0100817)1.77028188
85Shoulder girdle muscle weakness (HP:0003547)1.76937431
86Pelvic girdle muscle weakness (HP:0003749)1.76228244
87Horseshoe kidney (HP:0000085)1.76101615
88Facial hemangioma (HP:0000329)1.75485341
89Microvesicular hepatic steatosis (HP:0001414)1.74335313
90Clubbing of toes (HP:0100760)1.74031364
91Gastrointestinal atresia (HP:0002589)1.73868771
92Bifid tongue (HP:0010297)1.73767034
93Short thumb (HP:0009778)1.73027506
94Abnormality of the nasal septum (HP:0000419)1.71756583
95Abnormal hair whorl (HP:0010721)1.71478517
96Long clavicles (HP:0000890)1.71435309
97Transitional cell carcinoma of the bladder (HP:0006740)1.71100515
98Papillary thyroid carcinoma (HP:0002895)1.70395285
99Leiomyosarcoma (HP:0100243)1.69128205
100Uterine leiomyosarcoma (HP:0002891)1.69128205
101Abnormality of chromosome segregation (HP:0002916)1.69112694
102Abnormality of cochlea (HP:0000375)1.69081971
103Chin dimple (HP:0010751)1.69052100
104Hypospadias (HP:0000047)1.69047154
105Abnormality of the parietal bone (HP:0002696)1.68803305
106Neoplasm of the adrenal gland (HP:0100631)1.68454944
107Spinal cord lesions (HP:0100561)1.66130815
108Syringomyelia (HP:0003396)1.66130815
109Impulsivity (HP:0100710)1.65248149
110Hyperacusis (HP:0010780)1.64606972
111Tubulointerstitial nephritis (HP:0001970)1.63261794
112Microtia (HP:0008551)1.62823839
113Gastrointestinal carcinoma (HP:0002672)1.62261441
114Malignant gastrointestinal tract tumors (HP:0006749)1.62261441
115Duplicated collecting system (HP:0000081)1.62167592
116Cystic hygroma (HP:0000476)1.62151628
117Hypoplastic labia majora (HP:0000059)1.61208971
118Broad thumb (HP:0011304)1.60753661
119Abnormality of the intervertebral disk (HP:0005108)1.59703708
120Skin tags (HP:0010609)1.59203222
121Bladder neoplasm (HP:0009725)1.58910182
122Bladder carcinoma (HP:0002862)1.58910182
123Tracheoesophageal fistula (HP:0002575)1.58869150
124Sloping forehead (HP:0000340)1.58342738
125Dandy-Walker malformation (HP:0001305)1.57947088
126Preaxial hand polydactyly (HP:0001177)1.57319206
127Abnormality of the antihelix (HP:0009738)1.57192055
128Short middle phalanx of the 5th finger (HP:0004220)1.56879417
129Elfin facies (HP:0004428)1.56484244
130Aqueductal stenosis (HP:0002410)1.55399273
131Abnormality of the parathyroid morphology (HP:0011766)1.54156799
132Choanal atresia (HP:0000453)1.52474607
133Hypoplastic female external genitalia (HP:0012815)1.52337768
134Prominent nose (HP:0000448)1.52315617
135Abnormality of the hip-girdle musculature (HP:0001445)1.51894733
136Abnormality of the musculature of the pelvis (HP:0001469)1.51894733
137Hypoplastic pelvis (HP:0008839)1.51839526
138Abnormality of homocysteine metabolism (HP:0010919)1.51311689
139Homocystinuria (HP:0002156)1.51311689
140Arteriovenous malformation (HP:0100026)1.50779964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.67988380
2SRPK13.89507902
3MKNK13.57855173
4MKNK23.04834605
5BRD43.01272738
6CDK122.86257941
7WEE12.51284671
8BUB12.15015514
9ATR2.14108972
10NEK22.13469981
11PASK2.03228153
12PLK31.88668658
13TTK1.86495402
14TSSK61.85852485
15TRIM281.80013827
16ACVR1B1.72252077
17MAP3K41.66383503
18LATS11.65745884
19ERBB31.63979429
20EEF2K1.60451040
21CHEK11.58055487
22PLK11.57266622
23PNCK1.52927238
24TGFBR11.52482354
25CDK71.52301663
26CHEK21.52098952
27TLK11.51395222
28AURKB1.49596981
29PBK1.46455694
30TAF11.45588767
31DYRK31.43918989
32PLK41.42226877
33RPS6KB21.40126188
34BRSK21.39691544
35MAP3K101.38290255
36ATM1.33962413
37ZAK1.32756976
38VRK11.32391207
39PDK21.29114295
40YES11.27538668
41BMPR1B1.10238882
42CDK21.09719498
43CDK41.06885766
44CCNB11.06813548
45* CDK11.02279055
46CLK10.97336127
47STK40.95869841
48CDK60.94325983
49FGFR10.91414390
50BCR0.91303076
51EIF2AK20.90012163
52MELK0.88822647
53RPS6KA40.88345569
54BRSK10.88084501
55EIF2AK10.87879531
56MAPK130.87638204
57KSR10.85343088
58CDK80.82827963
59CSNK1A1L0.82344975
60TNIK0.81407069
61NUAK10.81212958
62STK38L0.80620490
63CAMK1G0.80360180
64STK390.78454822
65MAP4K20.78064135
66EIF2AK30.77916567
67SIK30.77053082
68CAMK1D0.75058507
69FRK0.75027371
70ALK0.74375254
71CDK90.73588155
72MTOR0.73109639
73STK30.72431610
74PRKDC0.71396194
75NEK10.70925396
76MAP3K80.70384884
77CSNK1G20.67775702
78AURKA0.66660011
79CSNK1E0.66609069
80CDK30.65351371
81MAPK140.65220199
82EPHB20.65104772
83MAP2K70.64609247
84TAOK20.63357358
85CSNK2A20.62712048
86FGFR20.61702028
87STK160.61231630
88SIK20.60693869
89VRK20.60611295
90CSNK1D0.59874329
91NLK0.58555197
92AKT30.56440051
93PAK40.54728355
94* GSK3B0.54210315
95UHMK10.53373626
96ERBB20.52169447
97RPS6KA50.50846806
98AKT10.49789658
99WNK30.49491258
100PLK20.48779034
101MARK10.48753797
102AKT20.47438421
103MST40.45969206
104RPS6KB10.45449668
105CASK0.44453729
106SCYL20.44076853
107CSNK1G30.44054522
108STK100.42824753
109CSNK1G10.42550314
110CSNK2A10.41722422
111SMG10.40932349
112WNK40.40913039
113DYRK1A0.40863879
114* MAPK80.39536131
115MAPK90.39047125
116NEK60.37909303
117ICK0.37894564
118PAK20.37880064
119CHUK0.36073432
120DYRK20.36047565
121OXSR10.35968515
122PIM10.35268470

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.52553318
2Mismatch repair_Homo sapiens_hsa034303.48781343
3Spliceosome_Homo sapiens_hsa030403.47413673
4Cell cycle_Homo sapiens_hsa041102.82210419
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.78347980
6RNA transport_Homo sapiens_hsa030132.76361768
7mRNA surveillance pathway_Homo sapiens_hsa030152.67178038
8Homologous recombination_Homo sapiens_hsa034402.54418345
9Fanconi anemia pathway_Homo sapiens_hsa034602.48487515
10Base excision repair_Homo sapiens_hsa034102.40193557
11Non-homologous end-joining_Homo sapiens_hsa034502.34507705
12Nucleotide excision repair_Homo sapiens_hsa034202.29247530
13RNA degradation_Homo sapiens_hsa030182.01208611
14One carbon pool by folate_Homo sapiens_hsa006702.00042036
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94251177
16RNA polymerase_Homo sapiens_hsa030201.82932332
17Systemic lupus erythematosus_Homo sapiens_hsa053221.78833557
18Basal transcription factors_Homo sapiens_hsa030221.77254250
19Basal cell carcinoma_Homo sapiens_hsa052171.76311067
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75213334
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65212757
22Selenocompound metabolism_Homo sapiens_hsa004501.62970045
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54999623
24Protein export_Homo sapiens_hsa030601.51854624
25Ribosome_Homo sapiens_hsa030101.49537021
26MicroRNAs in cancer_Homo sapiens_hsa052061.45563913
27Steroid biosynthesis_Homo sapiens_hsa001001.43938436
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.33760737
29p53 signaling pathway_Homo sapiens_hsa041151.32448732
30Pyrimidine metabolism_Homo sapiens_hsa002401.28930724
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27947610
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27101060
33Oocyte meiosis_Homo sapiens_hsa041141.24490278
34Viral carcinogenesis_Homo sapiens_hsa052031.24278443
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22582773
36Colorectal cancer_Homo sapiens_hsa052101.22495598
37Alcoholism_Homo sapiens_hsa050341.22494843
38Hedgehog signaling pathway_Homo sapiens_hsa043401.20526666
39Hippo signaling pathway_Homo sapiens_hsa043901.20203339
40HTLV-I infection_Homo sapiens_hsa051661.14923660
41Propanoate metabolism_Homo sapiens_hsa006401.12294205
42Wnt signaling pathway_Homo sapiens_hsa043101.10879246
43Epstein-Barr virus infection_Homo sapiens_hsa051691.09844150
44Biosynthesis of amino acids_Homo sapiens_hsa012301.08533068
45TGF-beta signaling pathway_Homo sapiens_hsa043501.07488166
46Notch signaling pathway_Homo sapiens_hsa043301.06755103
47Herpes simplex infection_Homo sapiens_hsa051681.05258927
48Adherens junction_Homo sapiens_hsa045201.02179543
49Lysine degradation_Homo sapiens_hsa003100.97811573
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95211822
51Chronic myeloid leukemia_Homo sapiens_hsa052200.91196609
52Small cell lung cancer_Homo sapiens_hsa052220.90937834
53Thyroid cancer_Homo sapiens_hsa052160.84340694
54Prostate cancer_Homo sapiens_hsa052150.81810035
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81164340
56Primary immunodeficiency_Homo sapiens_hsa053400.80409174
57Endometrial cancer_Homo sapiens_hsa052130.79714494
58Axon guidance_Homo sapiens_hsa043600.78828150
59Viral myocarditis_Homo sapiens_hsa054160.78649027
60Pathways in cancer_Homo sapiens_hsa052000.76002615
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74798729
62Proteasome_Homo sapiens_hsa030500.74590192
63Pyruvate metabolism_Homo sapiens_hsa006200.73903426
64Purine metabolism_Homo sapiens_hsa002300.71922817
65Carbon metabolism_Homo sapiens_hsa012000.65724567
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65082593
67Antigen processing and presentation_Homo sapiens_hsa046120.64202665
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63766316
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63397460
70T cell receptor signaling pathway_Homo sapiens_hsa046600.62971876
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62488590
72Proteoglycans in cancer_Homo sapiens_hsa052050.59619050
73Non-small cell lung cancer_Homo sapiens_hsa052230.59474733
74Hepatitis B_Homo sapiens_hsa051610.59239355
75Butanoate metabolism_Homo sapiens_hsa006500.56431725
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55745389
77Melanoma_Homo sapiens_hsa052180.55474026
78mTOR signaling pathway_Homo sapiens_hsa041500.53213078
79Pancreatic cancer_Homo sapiens_hsa052120.52842243
80FoxO signaling pathway_Homo sapiens_hsa040680.52784940
81Melanogenesis_Homo sapiens_hsa049160.52398004
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.51288340
83Measles_Homo sapiens_hsa051620.47789550
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47498626
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46309416
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45183543
87Vitamin B6 metabolism_Homo sapiens_hsa007500.44289784
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44057533
89Tight junction_Homo sapiens_hsa045300.42754959
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.41406676
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41267113
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40876107
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40776334
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40119498
95Glioma_Homo sapiens_hsa052140.39497057
96ErbB signaling pathway_Homo sapiens_hsa040120.37586484
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37328131
98Acute myeloid leukemia_Homo sapiens_hsa052210.36502977
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36436911
100MAPK signaling pathway_Homo sapiens_hsa040100.34906952
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34774389
102Hematopoietic cell lineage_Homo sapiens_hsa046400.33660268
103Renal cell carcinoma_Homo sapiens_hsa052110.33512297
104N-Glycan biosynthesis_Homo sapiens_hsa005100.33501067
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.33173348
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32707920
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32161653
108Rap1 signaling pathway_Homo sapiens_hsa040150.32055176
109Focal adhesion_Homo sapiens_hsa045100.31041898
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30787790
111Bladder cancer_Homo sapiens_hsa052190.30431518
112Apoptosis_Homo sapiens_hsa042100.30071999
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29712375
114Influenza A_Homo sapiens_hsa051640.29651066
115Phototransduction_Homo sapiens_hsa047440.29571555
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29316241
117Nitrogen metabolism_Homo sapiens_hsa009100.28430920
118Circadian rhythm_Homo sapiens_hsa047100.27750592
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26686187
120Inositol phosphate metabolism_Homo sapiens_hsa005620.25448650
121Long-term potentiation_Homo sapiens_hsa047200.24902867
122B cell receptor signaling pathway_Homo sapiens_hsa046620.24784357
123Taste transduction_Homo sapiens_hsa047420.24580817
124HIF-1 signaling pathway_Homo sapiens_hsa040660.23688207
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23470580
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.22080381
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21532120
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20876193
129Fatty acid metabolism_Homo sapiens_hsa012120.16030589
130Pentose phosphate pathway_Homo sapiens_hsa000300.14913351
131Huntingtons disease_Homo sapiens_hsa050160.10876502
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10801585
133AMPK signaling pathway_Homo sapiens_hsa041520.09445474
134Choline metabolism in cancer_Homo sapiens_hsa052310.07675145

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