ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA unwinding involved in DNA replication (GO:0006268)	4.68827644
2	nuclear pore complex assembly (GO:0051292)	4.63702381
3	nuclear pore organization (GO:0006999)	4.50127044
4	mitotic sister chromatid cohesion (GO:0007064)	4.39420766
5	kinetochore organization (GO:0051383)	4.11478006
6	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	4.07818115
7	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.03297099
8	non-recombinational repair (GO:0000726)	3.92361100
9	double-strand break repair via nonhomologous end joining (GO:0006303)	3.92361100
10	establishment of integrated proviral latency (GO:0075713)	3.89563125
11	negative regulation of RNA splicing (GO:0033119)	3.84177189
12	DNA ligation (GO:0006266)	3.80772570
13	pre-miRNA processing (GO:0031054)	3.70802781
14	negative regulation of mRNA processing (GO:0050686)	3.66105810
15	DNA topological change (GO:0006265)	3.63878550
16	protein localization to kinetochore (GO:0034501)	3.60744158
17	mRNA splice site selection (GO:0006376)	3.58843983
18	kinetochore assembly (GO:0051382)	3.56079983
19	regulation of DNA endoreduplication (GO:0032875)	3.54991872
20	pore complex assembly (GO:0046931)	3.53056629
21	sister chromatid segregation (GO:0000819)	3.47531879
22	mitotic chromosome condensation (GO:0007076)	3.46106394
23	DNA replication-dependent nucleosome assembly (GO:0006335)	3.42817710
24	DNA replication-dependent nucleosome organization (GO:0034723)	3.42817710
25	DNA duplex unwinding (GO:0032508)	3.35283367
26	DNA geometric change (GO:0032392)	3.33998744
27	DNA replication-independent nucleosome assembly (GO:0006336)	3.31592683
28	DNA replication-independent nucleosome organization (GO:0034724)	3.31592683
29	regulation of RNA export from nucleus (GO:0046831)	3.28459202
30	chromatin remodeling at centromere (GO:0031055)	3.27688944
31	mitotic nuclear envelope disassembly (GO:0007077)	3.26317030
32	mitotic metaphase plate congression (GO:0007080)	3.25350645
33	CENP-A containing nucleosome assembly (GO:0034080)	3.23777506
34	negative regulation of mRNA metabolic process (GO:1903312)	3.19358722
35	DNA double-strand break processing (GO:0000729)	3.18368283
36	regulation of histone H3-K9 methylation (GO:0051570)	3.16804026
37	DNA replication initiation (GO:0006270)	3.14820813
38	negative regulation of histone methylation (GO:0031061)	3.13693988
39	DNA replication checkpoint (GO:0000076)	3.11861489
40	ATP-dependent chromatin remodeling (GO:0043044)	3.11826626
41	alternative mRNA splicing, via spliceosome (GO:0000380)	3.11434952
42	establishment of chromosome localization (GO:0051303)	3.11139937
43	metaphase plate congression (GO:0051310)	3.10871696
44	protein localization to chromosome, centromeric region (GO:0071459)	3.10655072
45	V(D)J recombination (GO:0033151)	3.10044763
46	dosage compensation (GO:0007549)	3.09670186
47	histone H2A acetylation (GO:0043968)	3.08930239
48	regulation of helicase activity (GO:0051095)	3.08918596
49	paraxial mesoderm development (GO:0048339)	3.07550302
50	regulation of centriole replication (GO:0046599)	3.06353294
51	spindle assembly checkpoint (GO:0071173)	3.05296810
52	DNA strand elongation involved in DNA replication (GO:0006271)	3.04951540
53	nuclear envelope disassembly (GO:0051081)	3.04564834
54	membrane disassembly (GO:0030397)	3.04564834
55	mRNA splicing, via spliceosome (GO:0000398)	3.03052306
56	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)	3.03052306
57	mitotic sister chromatid segregation (GO:0000070)	3.02586871
58	regulation of DNA damage checkpoint (GO:2000001)	3.01359640
59	RNA splicing, via transesterification reactions (GO:0000375)	3.00468792
60	telomere maintenance via recombination (GO:0000722)	3.00015979
61	replication fork processing (GO:0031297)	2.98653108
62	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.98340881
63	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.98340881
64	spindle checkpoint (GO:0031577)	2.98250326
65	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.98246316
66	negative regulation of sister chromatid segregation (GO:0033046)	2.98246316
67	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.98246316
68	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.98246316
69	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.97925038
70	ribosome assembly (GO:0042255)	2.97651391
71	mitotic spindle assembly checkpoint (GO:0007094)	2.97136135
72	positive regulation of cell cycle checkpoint (GO:1901978)	2.96674394
73	regulation of sister chromatid cohesion (GO:0007063)	2.95882172
74	negative regulation of chromosome segregation (GO:0051985)	2.95705073
75	negative regulation of DNA recombination (GO:0045910)	2.95667851
76	DNA strand elongation (GO:0022616)	2.95457155
77	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.95329113
78	chromatin assembly or disassembly (GO:0006333)	2.95051458
79	heterochromatin organization (GO:0070828)	2.94846854
80	mitotic recombination (GO:0006312)	2.94816159
81	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.94548204
82	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.94383575
83	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.94383575
84	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.94383575
85	chromosome segregation (GO:0007059)	2.94373102
86	histone exchange (GO:0043486)	2.93852782
87	termination of RNA polymerase II transcription (GO:0006369)	2.92797605
88	mitotic spindle checkpoint (GO:0071174)	2.91796942
89	regulation of mitotic spindle checkpoint (GO:1903504)	2.90897020
90	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.90897020
91	regulation of mitotic metaphase/anaphase transition (GO:0030071)	2.90839349
92	histone H3-K9 methylation (GO:0051567)	2.89141487
93	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.88254945
94	protein localization to chromosome (GO:0034502)	2.87856038
95	RNA export from nucleus (GO:0006405)	2.87644337
96	DNA conformation change (GO:0071103)	2.87306952
97	chromatin assembly (GO:0031497)	2.84145484
98	attachment of spindle microtubules to kinetochore (GO:0008608)	2.83906730
99	mRNA export from nucleus (GO:0006406)	2.83830161
100	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.83287085
101	IMP biosynthetic process (GO:0006188)	2.82210452
102	regulation of sister chromatid segregation (GO:0033045)	2.82017891
103	regulation of mitotic sister chromatid separation (GO:0010965)	2.82017891
104	regulation of mitotic sister chromatid segregation (GO:0033047)	2.82017891
105	mRNA transport (GO:0051028)	2.80445794
106	regulation of chromosome segregation (GO:0051983)	2.80395600
107	meiotic chromosome segregation (GO:0045132)	2.78635183
108	protein-DNA complex disassembly (GO:0032986)	2.76268412
109	nucleosome disassembly (GO:0006337)	2.76268412
110	translesion synthesis (GO:0019985)	2.75756163
111	intra-S DNA damage checkpoint (GO:0031573)	2.75415943
112	regulation of spindle organization (GO:0090224)	2.73972392
113	telomere maintenance via semi-conservative replication (GO:0032201)	2.73424158
114	regulation of centrosome cycle (GO:0046605)	2.73121943
115	positive regulation of histone H3-K4 methylation (GO:0051571)	2.72702987
116	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.70488463
117	microtubule depolymerization (GO:0007019)	2.68573443
118	peptidyl-lysine trimethylation (GO:0018023)	2.68463439
119	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.68111208
120	sister chromatid cohesion (GO:0007062)	2.66330861
121	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	2.65954904
122	positive regulation of chromosome segregation (GO:0051984)	2.63939604
123	mismatch repair (GO:0006298)	2.63680594
124	regulation of centrosome duplication (GO:0010824)	2.63133127

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	5.30189086
2	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.70919131
3	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	3.37990485
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.36270496
5	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.35171465
6	* MYC_18555785_ChIP-Seq_MESCs_Mouse	3.33905492
7	TP63_19390658_ChIP-ChIP_HaCaT_Human	3.30869870
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.19399940
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.17373225
10	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.66424719
11	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.43463791
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.40060148
13	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.39451612
14	* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.33912875
15	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.26457159
16	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.18244068
17	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.08978199
18	CIITA_25753668_ChIP-Seq_RAJI_Human	2.06477633
19	E2F7_22180533_ChIP-Seq_HELA_Human	10.7100012
20	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.97924597
21	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.94599389
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93199104
23	AR_21909140_ChIP-Seq_LNCAP_Human	1.86721686
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.84391024
25	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.84136106
26	* XRN2_22483619_ChIP-Seq_HELA_Human	1.79428050
27	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.72718311
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.72215244
29	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.69256948
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.67321532
31	* SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.61596553
32	* TTF2_22483619_ChIP-Seq_HELA_Human	1.61297314
33	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.60856924
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.59866774
35	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.57992174
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.56749409
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.55689079
38	MYC_22102868_ChIP-Seq_BL_Human	1.54385292
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.51421437
40	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.50283916
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.49817493
42	* EWS_26573619_Chip-Seq_HEK293_Human	1.49470808
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.46037655
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.45804992
45	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.45455440
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.41991319
47	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.41407030
48	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.37239812
49	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.33857417
50	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.33779286
51	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.32889453
52	* FUS_26573619_Chip-Seq_HEK293_Human	1.31596750
53	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.30321870
54	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.29592757
55	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.27698594
56	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.25611047
57	* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24064601
58	ZNF274_21170338_ChIP-Seq_K562_Hela	1.22646697
59	* KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.22235918
60	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.21393144
61	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.18947856
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.17913058
63	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.16483169
64	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.16305412
65	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.11821658
66	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.11140009
67	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.11099005
68	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.10939767
69	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.10884432
70	* KDM5A_27292631_Chip-Seq_BREAST_Human	1.10444834
71	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.09832889
72	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.08051279
73	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.07371087
74	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07313985
75	MYC_18940864_ChIP-ChIP_HL60_Human	1.06909102
76	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.04148711
77	GABP_19822575_ChIP-Seq_HepG2_Human	1.01160995
78	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.99706383
79	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.99235112
80	DCP1A_22483619_ChIP-Seq_HELA_Human	0.99195702
81	* SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.97920017
82	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.97730542
83	* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.96592692
84	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.96432726
85	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.93277590
86	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.92740312
87	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91720956
88	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.91707008
89	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.90750007
90	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.89825127
91	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.89795992
92	* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.89152807
93	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.85878223
94	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.85167459
95	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.84715148
96	P300_19829295_ChIP-Seq_ESCs_Human	0.84701693
97	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.82960692
98	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.80986129
99	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.80972944
100	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.79477067
101	* DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.77910932
102	IRF1_19129219_ChIP-ChIP_H3396_Human	0.77460735
103	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.77226884
104	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.76863526
105	* TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.76620206
106	SOX9_26525672_Chip-Seq_HEART_Mouse	0.75237820
107	* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.74753662
108	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.74529963
109	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.74129425
110	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.73984272
111	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.72406266
112	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.70028488
113	* CHD1_26751641_Chip-Seq_LNCaP_Human	0.68824589
114	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.68445232
115	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.68036132
116	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.67749640
117	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.67231036

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	3.56994699
2	MP0003111_abnormal_nucleus_morphology	3.22977172
3	MP0008057_abnormal_DNA_replication	3.22251690
4	MP0003121_genomic_imprinting	3.07378436
5	MP0003693_abnormal_embryo_hatching	2.95511951
6	MP0003077_abnormal_cell_cycle	2.84422409
7	MP0008058_abnormal_DNA_repair	2.66700038
8	MP0003123_paternal_imprinting	2.66228211
9	MP0004957_abnormal_blastocyst_morpholog	2.46553896
10	MP0008877_abnormal_DNA_methylation	2.43143400
11	MP0003787_abnormal_imprinting	2.26595483
12	MP0002009_preneoplasia	2.22641558
13	MP0000569_abnormal_digit_pigmentation	2.22341677
14	MP0003122_maternal_imprinting	2.21902757
15	MP0008007_abnormal_cellular_replicative	2.12210412
16	MP0003890_abnormal_embryonic-extraembry	2.08769014
17	MP0000537_abnormal_urethra_morphology	1.97123677
18	MP0006292_abnormal_olfactory_placode	1.96002541
19	MP0010030_abnormal_orbit_morphology	1.95510661
20	MP0009697_abnormal_copulation	1.84043806
21	MP0008932_abnormal_embryonic_tissue	1.82682818
22	MP0001293_anophthalmia	1.82436021
23	MP0002938_white_spotting	1.79811421
24	MP0000350_abnormal_cell_proliferation	1.72381820
25	MP0003937_abnormal_limbs/digits/tail_de	1.69826497
26	MP0009053_abnormal_anal_canal	1.62954639
27	MP0002084_abnormal_developmental_patter	1.60738840
28	MP0002085_abnormal_embryonic_tissue	1.59309114
29	MP0001730_embryonic_growth_arrest	1.57442196
30	MP0004197_abnormal_fetal_growth/weight/	1.55845001
31	MP0000566_synostosis	1.54332068
32	MP0002396_abnormal_hematopoietic_system	1.52009628
33	MP0003567_abnormal_fetal_cardiomyocyte	1.50304602
34	MP0001672_abnormal_embryogenesis/_devel	1.48344850
35	MP0005380_embryogenesis_phenotype	1.48344850
36	MP0003941_abnormal_skin_development	1.46194917
37	MP0005076_abnormal_cell_differentiation	1.43627501
38	MP0000049_abnormal_middle_ear	1.43097808
39	MP0003385_abnormal_body_wall	1.41581652
40	MP0001697_abnormal_embryo_size	1.36448633
41	MP0003119_abnormal_digestive_system	1.35616370
42	MP0003984_embryonic_growth_retardation	1.32398240
43	MP0001286_abnormal_eye_development	1.32362344
44	MP0003935_abnormal_craniofacial_develop	1.31571554
45	MP0002088_abnormal_embryonic_growth/wei	1.31025482
46	MP0003718_maternal_effect	1.30252469
47	MP0003221_abnormal_cardiomyocyte_apopto	1.30187391
48	MP0004808_abnormal_hematopoietic_stem	1.29154428
49	MP0008789_abnormal_olfactory_epithelium	1.29110818
50	MP0003861_abnormal_nervous_system	1.28018760
51	MP0010352_gastrointestinal_tract_polyps	1.27317959
52	MP0003315_abnormal_perineum_morphology	1.23459213
53	MP0003786_premature_aging	1.21978940
54	MP0009703_decreased_birth_body	1.21010878
55	MP0003755_abnormal_palate_morphology	1.18872330
56	MP0000428_abnormal_craniofacial_morphol	1.18558135
57	MP0003115_abnormal_respiratory_system	1.18477199
58	MP0003942_abnormal_urinary_system	1.17748743
59	MP0002653_abnormal_ependyma_morphology	1.16612367
60	MP0010307_abnormal_tumor_latency	1.15723541
61	MP0002086_abnormal_extraembryonic_tissu	1.15006553
62	MP0002080_prenatal_lethality	1.14760024
63	MP0002697_abnormal_eye_size	1.14528127
64	MP0009672_abnormal_birth_weight	1.12885218
65	MP0000432_abnormal_head_morphology	1.11531268
66	MP0002102_abnormal_ear_morphology	1.10975556
67	MP0002751_abnormal_autonomic_nervous	1.09277526
68	MP0002092_abnormal_eye_morphology	1.08232950
69	MP0005367_renal/urinary_system_phenotyp	1.08095402
70	MP0000516_abnormal_urinary_system	1.08095402
71	MP0005499_abnormal_olfactory_system	1.07820605
72	MP0005394_taste/olfaction_phenotype	1.07820605
73	MP0003938_abnormal_ear_development	1.07237625
74	MP0001529_abnormal_vocalization	1.04910998
75	MP0002116_abnormal_craniofacial_bone	1.04909964
76	MP0002233_abnormal_nose_morphology	1.03988981
77	MP0002111_abnormal_tail_morphology	1.03980870
78	MP0001188_hyperpigmentation	1.03717522
79	MP0000778_abnormal_nervous_system	1.02235052
80	MP0002249_abnormal_larynx_morphology	0.99993368
81	MP0002210_abnormal_sex_determination	0.99403706
82	MP0004133_heterotaxia	0.97243611
83	MP0002932_abnormal_joint_morphology	0.95536354
84	MP0000647_abnormal_sebaceous_gland	0.94997367
85	MP0001299_abnormal_eye_distance/	0.94254939
86	MP0001929_abnormal_gametogenesis	0.93768694
87	MP0000631_abnormal_neuroendocrine_gland	0.92945561
88	MP0002114_abnormal_axial_skeleton	0.92807506
89	MP0003136_yellow_coat_color	0.91608814
90	MP0008995_early_reproductive_senescence	0.91262462
91	MP0002177_abnormal_outer_ear	0.91035626
92	MP0005187_abnormal_penis_morphology	0.90798211
93	MP0002081_perinatal_lethality	0.90645703
94	MP0000313_abnormal_cell_death	0.90394253
95	MP0009250_abnormal_appendicular_skeleto	0.89728505
96	MP0000703_abnormal_thymus_morphology	0.88436202
97	MP0010234_abnormal_vibrissa_follicle	0.86025023
98	MP0002095_abnormal_skin_pigmentation	0.84062973
99	MP0005409_darkened_coat_color	0.83921785
100	MP0005174_abnormal_tail_pigmentation	0.82463280
101	MP0005253_abnormal_eye_physiology	0.82273314
102	MP0002109_abnormal_limb_morphology	0.82190736
103	MP0005220_abnormal_exocrine_pancreas	0.81889471
104	MP0000490_abnormal_crypts_of	0.80500892
105	MP0005645_abnormal_hypothalamus_physiol	0.79877670
106	MP0000733_abnormal_muscle_development	0.79820156
107	MP0010678_abnormal_skin_adnexa	0.79399342
108	MP0005391_vision/eye_phenotype	0.79391252
109	MP0001145_abnormal_male_reproductive	0.78453991
110	MP0002282_abnormal_trachea_morphology	0.78389288
111	MP0006072_abnormal_retinal_apoptosis	0.78316854
112	MP0005248_abnormal_Harderian_gland	0.77549361
113	MP0002925_abnormal_cardiovascular_devel	0.77112877
114	MP0000653_abnormal_sex_gland	0.75832818
115	MP0002234_abnormal_pharynx_morphology	0.75699459
116	MP0000383_abnormal_hair_follicle	0.75605520
117	MP0000372_irregular_coat_pigmentation	0.74980729
118	MP0001177_atelectasis	0.72543266
119	MP0003943_abnormal_hepatobiliary_system	0.72413704
120	MP0001346_abnormal_lacrimal_gland	0.69929722
121	MP0002184_abnormal_innervation	0.67761853
122	MP0002019_abnormal_tumor_incidence	0.66360446

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	3.59219707
2	Short 4th metacarpal (HP:0010044)	3.59219707
3	Chromsome breakage (HP:0040012)	3.28043438
4	Volvulus (HP:0002580)	3.25577565
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.24685827
6	Cortical dysplasia (HP:0002539)	3.15569249
7	Medulloblastoma (HP:0002885)	3.09510452
8	Neoplasm of the adrenal cortex (HP:0100641)	2.97702306
9	Abnormal number of incisors (HP:0011064)	2.78568714
10	Colon cancer (HP:0003003)	2.74278578
11	Ectopic kidney (HP:0000086)	2.72550424
12	Increased nuchal translucency (HP:0010880)	2.69246001
13	Abnormality of the labia minora (HP:0012880)	2.66570810
14	Ependymoma (HP:0002888)	2.57232266
15	Abnormality of the 4th metacarpal (HP:0010012)	2.47974961
16	Hepatoblastoma (HP:0002884)	2.47387436
17	Proximal placement of thumb (HP:0009623)	2.42973077
18	Meckel diverticulum (HP:0002245)	2.39849547
19	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.37699813
20	Renal duplication (HP:0000075)	2.35427621
21	Nephroblastoma (Wilms tumor) (HP:0002667)	2.34200116
22	Abnormal lung lobation (HP:0002101)	2.34029166
23	Trigonocephaly (HP:0000243)	2.33599229
24	Overlapping toe (HP:0001845)	2.33079712
25	Patellar aplasia (HP:0006443)	2.31890829
26	Midline defect of the nose (HP:0004122)	2.31354189
27	Deviation of the thumb (HP:0009603)	2.31101397
28	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.30178069
29	Abnormality of chromosome stability (HP:0003220)	2.29904921
30	Abnormality of the ileum (HP:0001549)	2.29448842
31	Long eyelashes (HP:0000527)	2.25212125
32	Abnormality of the fingertips (HP:0001211)	2.23971566
33	Embryonal renal neoplasm (HP:0011794)	2.20758234
34	Supernumerary ribs (HP:0005815)	2.20257549
35	Astrocytoma (HP:0009592)	2.18772000
36	Abnormality of the astrocytes (HP:0100707)	2.18772000
37	Aplasia/Hypoplasia of the patella (HP:0006498)	2.17646987
38	Birth length less than 3rd percentile (HP:0003561)	2.16345520
39	Supernumerary bones of the axial skeleton (HP:0009144)	2.13954030
40	Small intestinal stenosis (HP:0012848)	2.10068603
41	Duodenal stenosis (HP:0100867)	2.10068603
42	Glioma (HP:0009733)	2.09163181
43	Neoplasm of the oral cavity (HP:0100649)	2.07827482
44	Skull defect (HP:0001362)	2.05107005
45	Selective tooth agenesis (HP:0001592)	2.03395753
46	High anterior hairline (HP:0009890)	2.03156858
47	Anophthalmia (HP:0000528)	2.02118223
48	Abnormality of the preputium (HP:0100587)	2.01050629
49	Oligodactyly (HP:0012165)	2.00428466
50	Deep philtrum (HP:0002002)	1.99747485
51	Abnormality of the carotid arteries (HP:0005344)	1.99245658
52	Intestinal atresia (HP:0011100)	1.99165116
53	Atresia of the external auditory canal (HP:0000413)	1.96779329
54	Obsessive-compulsive behavior (HP:0000722)	1.96668055
55	Supernumerary spleens (HP:0009799)	1.96004099
56	Reticulocytopenia (HP:0001896)	1.95643093
57	Anal stenosis (HP:0002025)	1.95059291
58	Neoplasm of the colon (HP:0100273)	1.91617346
59	Absent radius (HP:0003974)	1.91384617
60	Embryonal neoplasm (HP:0002898)	1.89450327
61	Optic nerve coloboma (HP:0000588)	1.88462377
62	Triphalangeal thumb (HP:0001199)	1.88049782
63	Esophageal atresia (HP:0002032)	1.87011805
64	Abnormality of the duodenum (HP:0002246)	1.85839937
65	Rhabdomyosarcoma (HP:0002859)	1.85783294
66	Thyroid carcinoma (HP:0002890)	1.85008694
67	Abnormality of the incisor (HP:0000676)	1.84064950
68	Cafe-au-lait spot (HP:0000957)	1.83509938
69	Aplasia involving forearm bones (HP:0009822)	1.83293243
70	Absent forearm bone (HP:0003953)	1.83293243
71	Abnormality of the septum pellucidum (HP:0007375)	1.82757850
72	Neoplasm of striated muscle (HP:0009728)	1.82331486
73	Partial agenesis of the corpus callosum (HP:0001338)	1.81960043
74	Myelodysplasia (HP:0002863)	1.81520346
75	Facial cleft (HP:0002006)	1.81471185
76	Spastic diplegia (HP:0001264)	1.81367361
77	Abdominal situs inversus (HP:0003363)	1.80787563
78	Abnormality of abdominal situs (HP:0011620)	1.80787563
79	Oligodactyly (hands) (HP:0001180)	1.80419831
80	Sandal gap (HP:0001852)	1.80314115
81	Renal hypoplasia (HP:0000089)	1.79685127
82	Abnormality of DNA repair (HP:0003254)	1.77420817
83	Acute myeloid leukemia (HP:0004808)	1.77275900
84	Renovascular hypertension (HP:0100817)	1.77028188
85	Shoulder girdle muscle weakness (HP:0003547)	1.76937431
86	Pelvic girdle muscle weakness (HP:0003749)	1.76228244
87	Horseshoe kidney (HP:0000085)	1.76101615
88	Facial hemangioma (HP:0000329)	1.75485341
89	Microvesicular hepatic steatosis (HP:0001414)	1.74335313
90	Clubbing of toes (HP:0100760)	1.74031364
91	Gastrointestinal atresia (HP:0002589)	1.73868771
92	Bifid tongue (HP:0010297)	1.73767034
93	Short thumb (HP:0009778)	1.73027506
94	Abnormality of the nasal septum (HP:0000419)	1.71756583
95	Abnormal hair whorl (HP:0010721)	1.71478517
96	Long clavicles (HP:0000890)	1.71435309
97	Transitional cell carcinoma of the bladder (HP:0006740)	1.71100515
98	Papillary thyroid carcinoma (HP:0002895)	1.70395285
99	Leiomyosarcoma (HP:0100243)	1.69128205
100	Uterine leiomyosarcoma (HP:0002891)	1.69128205
101	Abnormality of chromosome segregation (HP:0002916)	1.69112694
102	Abnormality of cochlea (HP:0000375)	1.69081971
103	Chin dimple (HP:0010751)	1.69052100
104	Hypospadias (HP:0000047)	1.69047154
105	Abnormality of the parietal bone (HP:0002696)	1.68803305
106	Neoplasm of the adrenal gland (HP:0100631)	1.68454944
107	Syringomyelia (HP:0003396)	1.66130815
108	Spinal cord lesions (HP:0100561)	1.66130815
109	Impulsivity (HP:0100710)	1.65248149
110	Hyperacusis (HP:0010780)	1.64606972
111	Tubulointerstitial nephritis (HP:0001970)	1.63261794
112	Microtia (HP:0008551)	1.62823839
113	Gastrointestinal carcinoma (HP:0002672)	1.62261441
114	Malignant gastrointestinal tract tumors (HP:0006749)	1.62261441
115	Duplicated collecting system (HP:0000081)	1.62167592
116	Cystic hygroma (HP:0000476)	1.62151628
117	Hypoplastic labia majora (HP:0000059)	1.61208971
118	Broad thumb (HP:0011304)	1.60753661
119	Abnormality of the intervertebral disk (HP:0005108)	1.59703708
120	Skin tags (HP:0010609)	1.59203222
121	Bladder carcinoma (HP:0002862)	1.58910182
122	Bladder neoplasm (HP:0009725)	1.58910182
123	Tracheoesophageal fistula (HP:0002575)	1.58869150
124	Sloping forehead (HP:0000340)	1.58342738
125	Dandy-Walker malformation (HP:0001305)	1.57947088
126	Preaxial hand polydactyly (HP:0001177)	1.57319206
127	Abnormality of the antihelix (HP:0009738)	1.57192055
128	Short middle phalanx of the 5th finger (HP:0004220)	1.56879417
129	Elfin facies (HP:0004428)	1.56484244
130	Aqueductal stenosis (HP:0002410)	1.55399273
131	Abnormality of the parathyroid morphology (HP:0011766)	1.54156799
132	Choanal atresia (HP:0000453)	1.52474607
133	Hypoplastic female external genitalia (HP:0012815)	1.52337768
134	Prominent nose (HP:0000448)	1.52315617
135	Abnormality of the hip-girdle musculature (HP:0001445)	1.51894733
136	Abnormality of the musculature of the pelvis (HP:0001469)	1.51894733
137	Hypoplastic pelvis (HP:0008839)	1.51839526
138	Abnormality of homocysteine metabolism (HP:0010919)	1.51311689
139	Homocystinuria (HP:0002156)	1.51311689
140	Arteriovenous malformation (HP:0100026)	1.50779964

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.67988380
2	SRPK1	3.89507902
3	MKNK1	3.57855173
4	MKNK2	3.04834605
5	BRD4	3.01272738
6	CDK12	2.86257941
7	WEE1	2.51284671
8	BUB1	2.15015514
9	ATR	2.14108972
10	NEK2	2.13469981
11	PASK	2.03228153
12	PLK3	1.88668658
13	TTK	1.86495402
14	TSSK6	1.85852485
15	TRIM28	1.80013827
16	ACVR1B	1.72252077
17	MAP3K4	1.66383503
18	LATS1	1.65745884
19	ERBB3	1.63979429
20	EEF2K	1.60451040
21	CHEK1	1.58055487
22	PLK1	1.57266622
23	PNCK	1.52927238
24	TGFBR1	1.52482354
25	CDK7	1.52301663
26	CHEK2	1.52098952
27	TLK1	1.51395222
28	AURKB	1.49596981
29	PBK	1.46455694
30	TAF1	1.45588767
31	DYRK3	1.43918989
32	PLK4	1.42226877
33	RPS6KB2	1.40126188
34	BRSK2	1.39691544
35	MAP3K10	1.38290255
36	ATM	1.33962413
37	ZAK	1.32756976
38	VRK1	1.32391207
39	PDK2	1.29114295
40	YES1	1.27538668
41	BMPR1B	1.10238882
42	CDK2	1.09719498
43	CDK4	1.06885766
44	CCNB1	1.06813548
45	* CDK1	1.02279055
46	CLK1	0.97336127
47	STK4	0.95869841
48	CDK6	0.94325983
49	FGFR1	0.91414390
50	BCR	0.91303076
51	EIF2AK2	0.90012163
52	MELK	0.88822647
53	RPS6KA4	0.88345569
54	BRSK1	0.88084501
55	EIF2AK1	0.87879531
56	MAPK13	0.87638204
57	KSR1	0.85343088
58	CDK8	0.82827963
59	CSNK1A1L	0.82344975
60	TNIK	0.81407069
61	NUAK1	0.81212958
62	STK38L	0.80620490
63	CAMK1G	0.80360180
64	STK39	0.78454822
65	MAP4K2	0.78064135
66	EIF2AK3	0.77916567
67	SIK3	0.77053082
68	CAMK1D	0.75058507
69	FRK	0.75027371
70	ALK	0.74375254
71	CDK9	0.73588155
72	MTOR	0.73109639
73	STK3	0.72431610
74	PRKDC	0.71396194
75	NEK1	0.70925396
76	MAP3K8	0.70384884
77	CSNK1G2	0.67775702
78	AURKA	0.66660011
79	CSNK1E	0.66609069
80	CDK3	0.65351371
81	MAPK14	0.65220199
82	EPHB2	0.65104772
83	MAP2K7	0.64609247
84	TAOK2	0.63357358
85	CSNK2A2	0.62712048
86	FGFR2	0.61702028
87	STK16	0.61231630
88	SIK2	0.60693869
89	VRK2	0.60611295
90	CSNK1D	0.59874329
91	NLK	0.58555197
92	AKT3	0.56440051
93	PAK4	0.54728355
94	* GSK3B	0.54210315
95	UHMK1	0.53373626
96	ERBB2	0.52169447
97	RPS6KA5	0.50846806
98	AKT1	0.49789658
99	WNK3	0.49491258
100	PLK2	0.48779034
101	MARK1	0.48753797
102	AKT2	0.47438421
103	MST4	0.45969206
104	RPS6KB1	0.45449668
105	CASK	0.44453729
106	SCYL2	0.44076853
107	CSNK1G3	0.44054522
108	STK10	0.42824753
109	CSNK1G1	0.42550314
110	CSNK2A1	0.41722422
111	SMG1	0.40932349
112	WNK4	0.40913039
113	DYRK1A	0.40863879
114	* MAPK8	0.39536131
115	MAPK9	0.39047125
116	NEK6	0.37909303
117	ICK	0.37894564
118	PAK2	0.37880064
119	CHUK	0.36073432
120	DYRK2	0.36047565
121	OXSR1	0.35968515
122	PIM1	0.35268470

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.52553318
2	Mismatch repair_Homo sapiens_hsa03430	3.48781343
3	Spliceosome_Homo sapiens_hsa03040	3.47413673
4	Cell cycle_Homo sapiens_hsa04110	2.82210419
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.78347980
6	RNA transport_Homo sapiens_hsa03013	2.76361768
7	mRNA surveillance pathway_Homo sapiens_hsa03015	2.67178038
8	Homologous recombination_Homo sapiens_hsa03440	2.54418345
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.48487515
10	Base excision repair_Homo sapiens_hsa03410	2.40193557
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.34507705
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.29247530
13	RNA degradation_Homo sapiens_hsa03018	2.01208611
14	One carbon pool by folate_Homo sapiens_hsa00670	2.00042036
15	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.94251177
16	RNA polymerase_Homo sapiens_hsa03020	1.82932332
17	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.78833557
18	Basal transcription factors_Homo sapiens_hsa03022	1.77254250
19	Basal cell carcinoma_Homo sapiens_hsa05217	1.76311067
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.75213334
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.65212757
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.62970045
23	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.54999623
24	Protein export_Homo sapiens_hsa03060	1.51854624
25	Ribosome_Homo sapiens_hsa03010	1.49537021
26	MicroRNAs in cancer_Homo sapiens_hsa05206	1.45563913
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.43938436
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.33760737
29	p53 signaling pathway_Homo sapiens_hsa04115	1.32448732
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.28930724
31	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.27947610
32	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.27101060
33	Oocyte meiosis_Homo sapiens_hsa04114	1.24490278
34	Viral carcinogenesis_Homo sapiens_hsa05203	1.24278443
35	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.22582773
36	Colorectal cancer_Homo sapiens_hsa05210	1.22495598
37	Alcoholism_Homo sapiens_hsa05034	1.22494843
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.20526666
39	Hippo signaling pathway_Homo sapiens_hsa04390	1.20203339
40	HTLV-I infection_Homo sapiens_hsa05166	1.14923660
41	Propanoate metabolism_Homo sapiens_hsa00640	1.12294205
42	Wnt signaling pathway_Homo sapiens_hsa04310	1.10879246
43	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.09844150
44	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.08533068
45	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.07488166
46	Notch signaling pathway_Homo sapiens_hsa04330	1.06755103
47	Herpes simplex infection_Homo sapiens_hsa05168	1.05258927
48	Adherens junction_Homo sapiens_hsa04520	1.02179543
49	Lysine degradation_Homo sapiens_hsa00310	0.97811573
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.95211822
51	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.91196609
52	Small cell lung cancer_Homo sapiens_hsa05222	0.90937834
53	Thyroid cancer_Homo sapiens_hsa05216	0.84340694
54	Prostate cancer_Homo sapiens_hsa05215	0.81810035
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.81164340
56	Primary immunodeficiency_Homo sapiens_hsa05340	0.80409174
57	Endometrial cancer_Homo sapiens_hsa05213	0.79714494
58	Axon guidance_Homo sapiens_hsa04360	0.78828150
59	Viral myocarditis_Homo sapiens_hsa05416	0.78649027
60	Pathways in cancer_Homo sapiens_hsa05200	0.76002615
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74798729
62	Proteasome_Homo sapiens_hsa03050	0.74590192
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.73903426
64	Purine metabolism_Homo sapiens_hsa00230	0.71922817
65	Carbon metabolism_Homo sapiens_hsa01200	0.65724567
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65082593
67	Antigen processing and presentation_Homo sapiens_hsa04612	0.64202665
68	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.63766316
69	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.63397460
70	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62971876
71	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.62488590
72	Proteoglycans in cancer_Homo sapiens_hsa05205	0.59619050
73	Non-small cell lung cancer_Homo sapiens_hsa05223	0.59474733
74	Hepatitis B_Homo sapiens_hsa05161	0.59239355
75	Butanoate metabolism_Homo sapiens_hsa00650	0.56431725
76	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.55745389
77	Melanoma_Homo sapiens_hsa05218	0.55474026
78	mTOR signaling pathway_Homo sapiens_hsa04150	0.53213078
79	Pancreatic cancer_Homo sapiens_hsa05212	0.52842243
80	FoxO signaling pathway_Homo sapiens_hsa04068	0.52784940
81	Melanogenesis_Homo sapiens_hsa04916	0.52398004
82	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.51288340
83	Measles_Homo sapiens_hsa05162	0.47789550
84	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.47498626
85	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.46309416
86	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.45183543
87	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.44289784
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44057533
89	Tight junction_Homo sapiens_hsa04530	0.42754959
90	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.41406676
91	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.41267113
92	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.40876107
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40776334
94	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.40119498
95	Glioma_Homo sapiens_hsa05214	0.39497057
96	ErbB signaling pathway_Homo sapiens_hsa04012	0.37586484
97	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.37328131
98	Acute myeloid leukemia_Homo sapiens_hsa05221	0.36502977
99	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.36436911
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.34906952
101	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.34774389
102	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.33660268
103	Renal cell carcinoma_Homo sapiens_hsa05211	0.33512297
104	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33501067
105	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.33173348
106	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.32707920
107	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.32161653
108	Rap1 signaling pathway_Homo sapiens_hsa04015	0.32055176
109	Focal adhesion_Homo sapiens_hsa04510	0.31041898
110	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.30787790
111	Bladder cancer_Homo sapiens_hsa05219	0.30431518
112	Apoptosis_Homo sapiens_hsa04210	0.30071999
113	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.29712375
114	Influenza A_Homo sapiens_hsa05164	0.29651066
115	Phototransduction_Homo sapiens_hsa04744	0.29571555
116	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.29316241
117	Nitrogen metabolism_Homo sapiens_hsa00910	0.28430920
118	Circadian rhythm_Homo sapiens_hsa04710	0.27750592
119	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.26686187
120	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.25448650
121	Long-term potentiation_Homo sapiens_hsa04720	0.24902867
122	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.24784357
123	Taste transduction_Homo sapiens_hsa04742	0.24580817
124	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.23688207
125	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.23470580
126	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.22080381
127	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.21532120
128	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.20876193
129	Fatty acid metabolism_Homo sapiens_hsa01212	0.16030589
130	Pentose phosphate pathway_Homo sapiens_hsa00030	0.14913351
131	Huntingtons disease_Homo sapiens_hsa05016	0.10876502
132	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.10801585
133	AMPK signaling pathway_Homo sapiens_hsa04152	0.09445474
134	Choline metabolism in cancer_Homo sapiens_hsa05231	0.07675145

FUBP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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