FUCA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)5.71079227
2oligosaccharide catabolic process (GO:0009313)5.63337068
3negative regulation of interleukin-12 production (GO:0032695)5.53260260
4regulation of mononuclear cell migration (GO:0071675)5.26142598
5glycolipid catabolic process (GO:0019377)5.15958843
6cellular response to thyroid hormone stimulus (GO:0097067)4.85596152
7amino sugar catabolic process (GO:0046348)4.66769578
8ceramide catabolic process (GO:0046514)4.60400559
9N-acetylneuraminate metabolic process (GO:0006054)4.16927612
10membrane lipid catabolic process (GO:0046466)4.12248585
11T-helper 1 type immune response (GO:0042088)4.02733388
12macrophage activation involved in immune response (GO:0002281)4.00844012
13sphingolipid catabolic process (GO:0030149)3.89918401
14negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.88114198
15positive regulation of leukocyte degranulation (GO:0043302)3.85702172
16response to thyroid hormone (GO:0097066)3.80693634
17positive regulation of chemokine biosynthetic process (GO:0045080)3.77692617
18positive regulation of monocyte chemotaxis (GO:0090026)3.77051321
19regulation of macrophage chemotaxis (GO:0010758)3.73285078
20regulation of cytokine secretion involved in immune response (GO:0002739)3.72884238
21immunoglobulin mediated immune response (GO:0016064)3.70030185
22negative regulation of nitric oxide biosynthetic process (GO:0045019)3.64954254
23lipopolysaccharide-mediated signaling pathway (GO:0031663)3.60440791
24regulation of podosome assembly (GO:0071801)3.53474045
25regulation of mast cell degranulation (GO:0043304)3.52095153
26positive regulation of mast cell activation involved in immune response (GO:0033008)3.50458483
27positive regulation of mast cell degranulation (GO:0043306)3.50458483
28regulation of vitamin D biosynthetic process (GO:0060556)3.48508975
29sulfur amino acid catabolic process (GO:0000098)3.40224206
30positive regulation of mast cell activation (GO:0033005)3.38333837
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37945610
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37945610
33positive regulation of heat generation (GO:0031652)3.37522987
34positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.37318383
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.36327934
36monocyte chemotaxis (GO:0002548)3.32902483
37NIK/NF-kappaB signaling (GO:0038061)3.32353455
38L-phenylalanine metabolic process (GO:0006558)3.31927946
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.31927946
40myeloid dendritic cell differentiation (GO:0043011)3.29604468
41L-phenylalanine catabolic process (GO:0006559)3.28598815
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.28598815
43regulation of leukocyte degranulation (GO:0043300)3.25319133
44regulation of chemokine biosynthetic process (GO:0045073)3.25281780
45regulation of mast cell activation involved in immune response (GO:0033006)3.23343140
46negative regulation of cytokine production involved in immune response (GO:0002719)3.22482428
47drug transmembrane transport (GO:0006855)3.22388825
48cellular response to arsenic-containing substance (GO:0071243)3.22232613
49detection of molecule of bacterial origin (GO:0032490)3.19810555
50antigen processing and presentation of endogenous antigen (GO:0019883)3.19551534
51barbed-end actin filament capping (GO:0051016)3.17047714
52negative regulation of erythrocyte differentiation (GO:0045647)3.13729366
53regulation of fever generation (GO:0031620)3.12009692
54regulation of monocyte chemotaxis (GO:0090025)3.09939016
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09680564
56granulocyte activation (GO:0036230)3.09282187
57aromatic amino acid family catabolic process (GO:0009074)3.07598312
58interferon-gamma-mediated signaling pathway (GO:0060333)3.06848947
59regulation of membrane protein ectodomain proteolysis (GO:0051043)3.06332064
60cysteine metabolic process (GO:0006534)3.05075650
61urate metabolic process (GO:0046415)3.02388678
62drug transport (GO:0015893)3.01362681
63regulation of interferon-beta biosynthetic process (GO:0045357)3.00810560
64adenosine receptor signaling pathway (GO:0001973)2.99196599
65myeloid dendritic cell activation (GO:0001773)2.98267200
66negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.97825358
67aldehyde catabolic process (GO:0046185)2.97592125
68positive regulation of gamma-delta T cell activation (GO:0046645)2.97328926
69neutrophil activation involved in immune response (GO:0002283)2.95196551
70positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.94967761
71response to acidic pH (GO:0010447)2.94332462
72indole-containing compound catabolic process (GO:0042436)2.93923220
73indolalkylamine catabolic process (GO:0046218)2.93923220
74tryptophan catabolic process (GO:0006569)2.93923220
75regulation of vitamin metabolic process (GO:0030656)2.93385339
76regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.92373771
77regulation of superoxide anion generation (GO:0032928)2.91842069
78tryptophan metabolic process (GO:0006568)2.89366258
79keratan sulfate catabolic process (GO:0042340)2.88781366
80regulation of mast cell activation (GO:0033003)2.88546398
81macrophage activation (GO:0042116)2.88114973
82complement activation, alternative pathway (GO:0006957)2.87148708
83valine metabolic process (GO:0006573)2.86544027
84branching involved in labyrinthine layer morphogenesis (GO:0060670)2.86196660
85regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85281482
86amyloid precursor protein catabolic process (GO:0042987)2.85245048
87positive regulation of cholesterol efflux (GO:0010875)2.82999486
88regulation of antigen processing and presentation (GO:0002577)2.82486750
89regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81766616
90lytic vacuole organization (GO:0080171)2.81702645
91lysosome organization (GO:0007040)2.81702645
92peptide catabolic process (GO:0043171)2.81633708
93adhesion of symbiont to host (GO:0044406)2.81224672
94positive regulation of cellular amide metabolic process (GO:0034250)2.80936091
95protein carboxylation (GO:0018214)2.80896425
96peptidyl-glutamic acid carboxylation (GO:0017187)2.80896425
97negative regulation of myeloid cell apoptotic process (GO:0033033)2.80537167
98detection of other organism (GO:0098543)2.79395797
99macrophage differentiation (GO:0030225)2.78980860
100regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78043541
101triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.76956808
102phagosome maturation (GO:0090382)2.76478141
103glyoxylate metabolic process (GO:0046487)2.76305605
104germinal center formation (GO:0002467)2.76200957
105glucuronate metabolic process (GO:0019585)2.76055966
106uronic acid metabolic process (GO:0006063)2.76055966
107positive regulation by symbiont of host defense response (GO:0052509)2.74888225
108modulation by symbiont of host defense response (GO:0052031)2.74888225
109modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74888225
110modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74888225
111positive regulation by organism of defense response of other organism involved in symbiotic interact2.74888225
112modulation by symbiont of host immune response (GO:0052553)2.74888225
113amino-acid betaine metabolic process (GO:0006577)2.74826492
114dendritic cell differentiation (GO:0097028)2.74680245
115detection of external biotic stimulus (GO:0098581)2.74309352
116regulation of interleukin-12 production (GO:0032655)2.74209259
117epithelial cell differentiation involved in prostate gland development (GO:0060742)2.74029999
118cellular response to lipopolysaccharide (GO:0071222)2.73881246
119myeloid cell activation involved in immune response (GO:0002275)2.73274696
120positive regulation of interferon-alpha production (GO:0032727)2.72405306
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71734531
122homocysteine metabolic process (GO:0050667)2.71404435
123negative regulation of interleukin-1 beta production (GO:0032691)2.69268799
124regulation of cholesterol esterification (GO:0010872)2.64887558
125cellular modified amino acid catabolic process (GO:0042219)2.58830660
126regulation of cholesterol storage (GO:0010885)2.57479011
127alpha-linolenic acid metabolic process (GO:0036109)2.57274413
128angiotensin maturation (GO:0002003)2.55549953
129regulation of interferon-alpha production (GO:0032647)2.54468331
130phospholipid efflux (GO:0033700)2.51595655
131flavonoid metabolic process (GO:0009812)2.51528400
132carnitine metabolic process (GO:0009437)2.50999009
133regulation of triglyceride catabolic process (GO:0010896)2.50438849
134kynurenine metabolic process (GO:0070189)2.50325030
135short-chain fatty acid metabolic process (GO:0046459)2.49644535
136cellular glucuronidation (GO:0052695)2.49412696
137plasma lipoprotein particle clearance (GO:0034381)2.49283337
138low-density lipoprotein particle clearance (GO:0034383)2.48504172
139primary alcohol catabolic process (GO:0034310)2.48104114
140ethanol oxidation (GO:0006069)2.46877642
141UDP-N-acetylglucosamine metabolic process (GO:0006047)2.45074242
142positive regulation of antigen processing and presentation (GO:0002579)2.43493672
143ethanol metabolic process (GO:0006067)2.42640577
144fatty acid beta-oxidation (GO:0006635)2.42478777
145respiratory burst (GO:0045730)2.42461588
146lysine catabolic process (GO:0006554)2.42095174
147lysine metabolic process (GO:0006553)2.42095174
148urea metabolic process (GO:0019627)2.41263625
149urea cycle (GO:0000050)2.41263625
150fatty acid oxidation (GO:0019395)2.40166651
151bile acid biosynthetic process (GO:0006699)2.39360203
152lipid oxidation (GO:0034440)2.39326455
153high-density lipoprotein particle remodeling (GO:0034375)2.37360251
154positive regulation of natural killer cell differentiation (GO:0032825)2.37091223
155toxin transport (GO:1901998)2.35768057
156aminoglycoside antibiotic metabolic process (GO:0030647)2.34669359
157drug catabolic process (GO:0042737)2.33371007
158response to peptidoglycan (GO:0032494)2.32430769
159virion attachment to host cell (GO:0019062)2.32023369
160adhesion of symbiont to host cell (GO:0044650)2.32023369
161regulation of protein activation cascade (GO:2000257)2.31964669
162reverse cholesterol transport (GO:0043691)2.31429058
163regulation of complement activation (GO:0030449)2.30874277
164positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.29861478
165transcytosis (GO:0045056)2.29183348
166nitrogen cycle metabolic process (GO:0071941)2.28945329
167apoptotic cell clearance (GO:0043277)2.28642448
168mannose metabolic process (GO:0006013)2.28405055
169plasma lipoprotein particle remodeling (GO:0034369)2.27849789
170protein-lipid complex remodeling (GO:0034368)2.27849789
171macromolecular complex remodeling (GO:0034367)2.27849789
172aromatic amino acid family metabolic process (GO:0009072)2.27847236
173bile acid and bile salt transport (GO:0015721)2.27124879
174negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.26669247
175negative regulation of cholesterol transport (GO:0032375)2.26389089
176negative regulation of sterol transport (GO:0032372)2.26389089
177positive regulation of coagulation (GO:0050820)2.26180781
178NADP metabolic process (GO:0006739)2.23491789
179response to nitrosative stress (GO:0051409)2.22607012
180fatty acid catabolic process (GO:0009062)2.22125148
181low-density lipoprotein particle remodeling (GO:0034374)2.21925728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.44665277
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.49717997
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.12816943
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.06264329
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.80115279
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.71817435
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.50410238
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.15753565
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.10927464
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.79608363
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72007181
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.52556175
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.51508604
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.45110801
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.41944099
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.37295280
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36060189
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31017932
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.30083535
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27890739
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21817211
22SPI1_23127762_ChIP-Seq_K562_Human2.20516887
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20411844
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18047272
25TRIM28_21343339_ChIP-Seq_HEK293_Human2.14966230
26VDR_21846776_ChIP-Seq_THP-1_Human2.10618285
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88063186
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86430171
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.86260850
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80384628
31* SOX2_20726797_ChIP-Seq_SW620_Human1.66576467
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65407158
33TFEB_21752829_ChIP-Seq_HELA_Human1.64156703
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62623055
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.61978389
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61655648
37* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59796310
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59675997
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56425249
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.54464225
41CLOCK_20551151_ChIP-Seq_293T_Human1.51378139
42GATA4_25053715_ChIP-Seq_YYC3_Human1.48239744
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47358462
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45199156
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44563867
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43320935
47* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40749133
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40046315
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39546399
50* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39479331
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36221213
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33364917
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32420218
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32342381
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32325852
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32018750
57P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31279931
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30020430
59GATA1_19941826_ChIP-Seq_K562_Human1.28806117
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.28731670
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.28285655
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25999102
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.25692705
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25508367
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25503775
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22559250
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22032593
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21795064
69STAT1_20625510_ChIP-Seq_HELA_Human1.21751371
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20295541
71* SPI1_23547873_ChIP-Seq_NB4_Human1.18283697
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17381012
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15630145
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14665986
75VDR_24787735_ChIP-Seq_THP-1_Human1.12318449
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09796943
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09197306
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09130400
79GATA1_22025678_ChIP-Seq_K562_Human1.09012795
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07052154
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.06946713
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03807529
83PU_27001747_Chip-Seq_BMDM_Mouse1.03391921
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03211161
85TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02961612
86VDR_24763502_ChIP-Seq_THP-1_Human1.01706525
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01704125
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01634205
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01489120
90RUNX_20019798_ChIP-Seq_JUKART_Human1.01021259
91* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99571928
92BCOR_27268052_Chip-Seq_Bcells_Human0.99501339
93TCF7_22412390_ChIP-Seq_EML_Mouse0.99316132
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99253239
95RUNX1_22412390_ChIP-Seq_EML_Mouse0.99201404
96GATA6_25053715_ChIP-Seq_YYC3_Human0.98853614
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98014106
98BCL6_27268052_Chip-Seq_Bcells_Human0.97260608
99LXR_22292898_ChIP-Seq_THP-1_Human0.96803840
100KDM2B_26808549_Chip-Seq_DND41_Human0.95824124
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95796296
102* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94816862
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94297061
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93897101
105* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93639788
106SCL_19346495_ChIP-Seq_HPC-7_Human0.93503081
107NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92784693
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92784693
109* MAF_26560356_Chip-Seq_TH1_Human0.92569541
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92337779
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91125944
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89926063
113* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89659054
114CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89624310
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89250718
116GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89230405
117* MYB_26560356_Chip-Seq_TH2_Human0.88777485
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88774112
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88052599
120GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87489307
121CJUN_26792858_Chip-Seq_BT549_Human0.87255497
122* RACK7_27058665_Chip-Seq_MCF-7_Human0.86488680
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.85423461
124GATA2_19941826_ChIP-Seq_K562_Human0.84570252
125UTX_26944678_Chip-Seq_JUKART_Human0.84198245
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83948296
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83948296
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83349150
129VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83289459
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83066118
131ELF1_20517297_ChIP-Seq_JURKAT_Human0.80922013
132* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80605879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.78305283
2MP0002139_abnormal_hepatobiliary_system3.68204570
3MP0005058_abnormal_lysosome_morphology3.02815128
4MP0003191_abnormal_cellular_cholesterol2.64190723
5MP0008875_abnormal_xenobiotic_pharmacok2.59969131
6MP0001835_abnormal_antigen_presentation2.45542135
7MP0009840_abnormal_foam_cell2.43673347
8MP0005365_abnormal_bile_salt2.42608255
9MP0003436_decreased_susceptibility_to2.34679688
10MP0004510_myositis2.33661744
11MP0002138_abnormal_hepatobiliary_system2.31933473
12MP0005085_abnormal_gallbladder_physiolo2.26297886
13MP0003300_gastrointestinal_ulcer2.12337166
14MP0003724_increased_susceptibility_to2.09603988
15MP0004019_abnormal_vitamin_homeostasis1.97437974
16MP0008438_abnormal_cutaneous_collagen1.96681295
17MP0003690_abnormal_glial_cell1.95035066
18MP0009785_altered_susceptibility_to1.90718144
19MP0002148_abnormal_hypersensitivity_rea1.88747021
20MP0005332_abnormal_amino_acid1.88161036
21MP0003252_abnormal_bile_duct1.87995582
22MP0003195_calcinosis1.85766667
23MP0001666_abnormal_nutrient_absorption1.83603636
24MP0009643_abnormal_urine_homeostasis1.83432722
25MP0006082_CNS_inflammation1.81183311
26MP0003186_abnormal_redox_activity1.80411518
27MP0002419_abnormal_innate_immunity1.78286860
28MP0009764_decreased_sensitivity_to1.75300345
29MP0000685_abnormal_immune_system1.72295283
30MP0005025_abnormal_response_to1.70516579
31MP0005167_abnormal_blood-brain_barrier1.68119630
32MP0001790_abnormal_immune_system1.67949146
33MP0005387_immune_system_phenotype1.67949146
34MP0010329_abnormal_lipoprotein_level1.65723704
35MP0003806_abnormal_nucleotide_metabolis1.60489362
36MP0005000_abnormal_immune_tolerance1.56845093
37MP0009278_abnormal_bone_marrow1.53678536
38MP0001533_abnormal_skeleton_physiology1.47908019
39MP0002166_altered_tumor_susceptibility1.47898737
40MP0008469_abnormal_protein_level1.42559300
41MP0010155_abnormal_intestine_physiology1.41243696
42MP0005397_hematopoietic_system_phenotyp1.39528153
43MP0001545_abnormal_hematopoietic_system1.39528153
44MP0004782_abnormal_surfactant_physiolog1.38796779
45MP0001845_abnormal_inflammatory_respons1.37527275
46MP0002136_abnormal_kidney_physiology1.36937768
47MP0005464_abnormal_platelet_physiology1.36908603
48MP0002452_abnormal_antigen_presenting1.36361633
49MP0001958_emphysema1.35195158
50MP0001756_abnormal_urination1.32810167
51MP0004947_skin_inflammation1.31247029
52MP0005636_abnormal_mineral_homeostasis1.29405264
53MP0001873_stomach_inflammation1.29230397
54MP0005275_abnormal_skin_tensile1.29054195
55MP0005083_abnormal_biliary_tract1.26475716
56MP0003329_amyloid_beta_deposits1.26460198
57MP0005319_abnormal_enzyme/_coenzyme1.26173510
58MP0003303_peritoneal_inflammation1.23651292
59MP0000609_abnormal_liver_physiology1.23414731
60MP0000920_abnormal_myelination1.23247387
61MP0001800_abnormal_humoral_immune1.22816020
62MP0005310_abnormal_salivary_gland1.22724117
63MP0010234_abnormal_vibrissa_follicle1.21370426
64MP0002723_abnormal_immune_serum1.19300633
65MP0002254_reproductive_system_inflammat1.18796166
66MP0003172_abnormal_lysosome_physiology1.14712001
67MP0010386_abnormal_urinary_bladder1.13815472
68MP0001765_abnormal_ion_homeostasis1.13813725
69MP0000604_amyloidosis1.13805731
70MP0005584_abnormal_enzyme/coenzyme_acti1.13316351
71MP0002118_abnormal_lipid_homeostasis1.11882229
72MP0009333_abnormal_splenocyte_physiolog1.11844832
73MP0005671_abnormal_response_to1.10239450
74MP0000343_altered_response_to1.08975148
75MP0002006_tumorigenesis1.08706135
76MP0002090_abnormal_vision1.08294224
77MP0001819_abnormal_immune_cell1.06380351
78MP0006054_spinal_hemorrhage1.05693899
79MP0002420_abnormal_adaptive_immunity1.05020634
80MP0003705_abnormal_hypodermis_morpholog1.03057931
81MP0003866_abnormal_defecation1.02599041
82MP0005165_increased_susceptibility_to1.02225377
83MP0002405_respiratory_system_inflammati1.01472790
84MP0000716_abnormal_immune_system1.00376773
85MP0003828_pulmonary_edema1.00257101
86MP0003075_altered_response_to1.00138322
87MP0002998_abnormal_bone_remodeling0.98752565
88MP0000858_altered_metastatic_potential0.98053333
89MP0001853_heart_inflammation0.97206509
90MP0003566_abnormal_cell_adhesion0.96878712
91MP0004043_abnormal_pH_regulation0.94152661
92MP0008260_abnormal_autophagy0.92576392
93MP0005166_decreased_susceptibility_to0.91865070
94MP0010307_abnormal_tumor_latency0.90914592
95MP0001663_abnormal_digestive_system0.90870721
96MP0003453_abnormal_keratinocyte_physiol0.90604131
97MP0009763_increased_sensitivity_to0.90097236
98MP0002933_joint_inflammation0.89930614
99MP0005257_abnormal_intraocular_pressure0.89274596
100MP0002295_abnormal_pulmonary_circulatio0.89237901
101MP0002837_dystrophic_cardiac_calcinosis0.87936637
102MP0003656_abnormal_erythrocyte_physiolo0.87716339
103MP0001542_abnormal_bone_strength0.86408904
104MP0002132_abnormal_respiratory_system0.85885595
105MP0002796_impaired_skin_barrier0.84982107
106MP0003634_abnormal_glial_cell0.84849097
107MP0008004_abnormal_stomach_pH0.84423338
108MP0005164_abnormal_response_to0.84108658
109MP0002277_abnormal_respiratory_mucosa0.81641951
110MP0000465_gastrointestinal_hemorrhage0.80958555
111MP0005408_hypopigmentation0.80835378
112MP0000538_abnormal_urinary_bladder0.80700003
113MP0001764_abnormal_homeostasis0.80610922
114MP0002060_abnormal_skin_morphology0.80188244
115MP0002877_abnormal_melanocyte_morpholog0.80168239
116MP0005451_abnormal_body_composition0.80085522
117MP0003879_abnormal_hair_cell0.79807011
118MP0003448_altered_tumor_morphology0.79627268
119MP0003183_abnormal_peptide_metabolism0.79584748
120MP0000689_abnormal_spleen_morphology0.78719873
121MP0003011_delayed_dark_adaptation0.77543740
122MP0005390_skeleton_phenotype0.77118177
123MP0002332_abnormal_exercise_endurance0.77074295
124MP0004883_abnormal_blood_vessel0.76230564
125MP0002429_abnormal_blood_cell0.73670636
126MP0003795_abnormal_bone_structure0.71926204
127MP0003633_abnormal_nervous_system0.68806976
128MP0002398_abnormal_bone_marrow0.67346715
129MP0000490_abnormal_crypts_of0.65403353
130MP0000371_diluted_coat_color0.60453796
131MP0002722_abnormal_immune_system0.59931494
132MP0005647_abnormal_sex_gland0.56593002
133MP0005595_abnormal_vascular_smooth0.56370750
134MP0003091_abnormal_cell_migration0.55271534
135MP0000249_abnormal_blood_vessel0.54419494

Predicted human phenotypes

RankGene SetZ-score
1Disinhibition (HP:0000734)5.57179450
2Mutism (HP:0002300)4.82247771
3* Vacuolated lymphocytes (HP:0001922)4.61669210
4Neurofibrillary tangles (HP:0002185)4.10628320
5Nuclear cataract (HP:0100018)3.82321866
6Systemic lupus erythematosus (HP:0002725)3.75686915
7Recurrent gram-negative bacterial infections (HP:0005420)3.60580523
8Eczematoid dermatitis (HP:0000976)3.55992197
9Abnormality of glutamine family amino acid metabolism (HP:0010902)3.51913114
10Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.50518310
11Recurrent abscess formation (HP:0002722)3.35406043
12* Dysostosis multiplex (HP:0000943)3.33499273
13Apathy (HP:0000741)3.29389860
14Agnosia (HP:0010524)3.28966434
15Recurrent bacterial skin infections (HP:0005406)3.25863964
16Diminished motivation (HP:0000745)3.22635682
17Abnormality of macrophages (HP:0004311)3.19432752
18Inappropriate behavior (HP:0000719)3.18149343
19Abnormality of aromatic amino acid family metabolism (HP:0004338)3.13951525
20Retinal atrophy (HP:0001105)3.09328689
21Mediastinal lymphadenopathy (HP:0100721)3.09265076
22Glomerulonephritis (HP:0000099)3.07528608
23Xanthomatosis (HP:0000991)3.05093808
24Neuronal loss in central nervous system (HP:0002529)3.03290467
25Increased cerebral lipofuscin (HP:0011813)3.02883509
26Complement deficiency (HP:0004431)2.98523486
27Upper motor neuron abnormality (HP:0002127)2.97795642
28* Mucopolysacchariduria (HP:0008155)2.92752431
29* Urinary glycosaminoglycan excretion (HP:0003541)2.92752431
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.88651076
31Cerebral inclusion bodies (HP:0100314)2.88335143
32Progressive neurologic deterioration (HP:0002344)2.87846369
33Hematochezia (HP:0002573)2.85838045
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.81169231
35Hydroxyprolinuria (HP:0003080)2.80281323
36Abnormality of proline metabolism (HP:0010907)2.80281323
37Axonal loss (HP:0003447)2.74953642
38Hyperactive renin-angiotensin system (HP:0000841)2.74226317
39Autoimmune thrombocytopenia (HP:0001973)2.73400053
40Vascular calcification (HP:0004934)2.71784487
41Intrahepatic cholestasis (HP:0001406)2.70723880
42Generalized aminoaciduria (HP:0002909)2.67549365
43* Abnormality of glycosaminoglycan metabolism (HP:0004371)2.67083450
44* Abnormality of mucopolysaccharide metabolism (HP:0011020)2.67083450
45* Abnormality of polysaccharide metabolism (HP:0011012)2.67083450
46Personality changes (HP:0000751)2.66823524
47Hepatosplenomegaly (HP:0001433)2.66203554
48Retrobulbar optic neuritis (HP:0100654)2.66045308
49Optic neuritis (HP:0100653)2.66045308
50Hyperglycinuria (HP:0003108)2.64799433
51Myocardial infarction (HP:0001658)2.63474157
52Metaphyseal irregularity (HP:0003025)2.63300909
53Stomatitis (HP:0010280)2.62807457
54Abnormality of complement system (HP:0005339)2.61598352
55Cardiovascular calcification (HP:0011915)2.59468707
56Joint hemorrhage (HP:0005261)2.59281436
57Abnormality of fatty-acid metabolism (HP:0004359)2.54234568
58Increased serum ferritin (HP:0003281)2.51672290
59Dementia (HP:0000726)2.48249085
60Interstitial pulmonary disease (HP:0006530)2.48197450
61Deep venous thrombosis (HP:0002625)2.46139459
62Prolonged neonatal jaundice (HP:0006579)2.41485249
63Fat malabsorption (HP:0002630)2.40720626
64* Abnormality of the vasculature of the conjunctiva (HP:0008054)2.39806844
65Abnormality of purine metabolism (HP:0004352)2.38621544
66Nephritis (HP:0000123)2.37388162
67Chronic obstructive pulmonary disease (HP:0006510)2.31744238
68Obstructive lung disease (HP:0006536)2.31744238
69Prolonged partial thromboplastin time (HP:0003645)2.31076543
70Hyperammonemia (HP:0001987)2.30570558
71Global brain atrophy (HP:0002283)2.27481087
72Peripheral demyelination (HP:0011096)2.24712452
73Alkalosis (HP:0001948)2.23575133
74Metabolic alkalosis (HP:0200114)2.23180550
75Loss of speech (HP:0002371)2.22299831
76Abnormality of urine glucose concentration (HP:0011016)2.21465325
77Glycosuria (HP:0003076)2.21465325
78Pathologic fracture (HP:0002756)2.19957042
79Asymmetric septal hypertrophy (HP:0001670)2.19821517
80Basal ganglia calcification (HP:0002135)2.19319973
81Pustule (HP:0200039)2.18815079
82Conjunctival telangiectasia (HP:0000524)2.18471281
83Proximal tubulopathy (HP:0000114)2.17474144
84Pulmonary infiltrates (HP:0002113)2.16033629
85Hyperlipoproteinemia (HP:0010980)2.15646944
86Abnormality of glycine metabolism (HP:0010895)2.15421220
87Abnormality of serine family amino acid metabolism (HP:0010894)2.15421220
88* Abnormality of chloride homeostasis (HP:0011422)2.15062520
89Steatorrhea (HP:0002570)2.14124943
90Amyloidosis (HP:0011034)2.13460899
91Esophageal varix (HP:0002040)2.12871466
92Abnormality of liposaccharide metabolism (HP:0010968)2.11685059
93Abnormality of glycosphingolipid metabolism (HP:0004343)2.11685059
94Abnormality of glycolipid metabolism (HP:0010969)2.11685059
95Pancreatitis (HP:0001733)2.11041388
96Urticaria (HP:0001025)2.10580091
97Increased CSF protein (HP:0002922)2.10259543
98Ketosis (HP:0001946)2.08940798
99Abnormality of the common coagulation pathway (HP:0010990)2.08432093
100Recurrent skin infections (HP:0001581)2.06572206
101Multiple enchondromatosis (HP:0005701)2.06483762
102Conjugated hyperbilirubinemia (HP:0002908)2.05947902
103Hypokalemic alkalosis (HP:0001949)2.05294255
104Abnormality of the periventricular white matter (HP:0002518)2.05259283
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04797217
106Nausea (HP:0002018)2.04796847
107Gingivitis (HP:0000230)2.04760976
108Elevated erythrocyte sedimentation rate (HP:0003565)2.03659276
109Abnormality of nucleobase metabolism (HP:0010932)2.01094695
110Purpura (HP:0000979)1.99822437
111Hypoglycemic coma (HP:0001325)1.99522450
112Progressive visual loss (HP:0000529)1.99343833
113Memory impairment (HP:0002354)1.97487495
114Thoracic kyphosis (HP:0002942)1.97265454
115Supranuclear gaze palsy (HP:0000605)1.97123575
116Abnormality of iron homeostasis (HP:0011031)1.96982170
117Petechiae (HP:0000967)1.96102193
118Bone pain (HP:0002653)1.95703895
119Malnutrition (HP:0004395)1.94404233
120Gingival bleeding (HP:0000225)1.93781347
121Myositis (HP:0100614)1.93332784
122Gout (HP:0001997)1.91392448
123Vertebral compression fractures (HP:0002953)1.90520264
124Abnormality of sulfur amino acid metabolism (HP:0004339)1.90138090
125Protuberant abdomen (HP:0001538)1.88488244
126Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88256807
127Periodontitis (HP:0000704)1.88211084
128Tetraparesis (HP:0002273)1.87308708
129Abdominal distention (HP:0003270)1.84435047
130Abnormal enzyme/coenzyme activity (HP:0012379)1.84160118
131Abnormality of renal excretion (HP:0011036)1.84144935
132Ketoacidosis (HP:0001993)1.84066195
133Menorrhagia (HP:0000132)1.82342921
134Hypobetalipoproteinemia (HP:0003563)1.81627024
135Dicarboxylic aciduria (HP:0003215)1.81317020
136Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81317020
137Abnormality of magnesium homeostasis (HP:0004921)1.80758692
138Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80137628
139Spontaneous hematomas (HP:0007420)1.80013075
140Orchitis (HP:0100796)1.79751585
141Urinary incontinence (HP:0000020)1.79188781
142* Polyneuropathy (HP:0001271)1.78620564
143Hypomagnesemia (HP:0002917)1.77890359
144Ileus (HP:0002595)1.76359989
145Abnormal tarsal ossification (HP:0008369)1.76290524
146Hemoptysis (HP:0002105)1.75883450
147Sensorimotor neuropathy (HP:0007141)1.75730109
148Keratoconjunctivitis sicca (HP:0001097)1.74371420
149Mucosal telangiectasiae (HP:0100579)1.72314124
150* Cardiomegaly (HP:0001640)1.72126770
151Abnormality of the basal ganglia (HP:0002134)1.70680075
152Abnormality of the nasal mucosa (HP:0000433)1.68519118
153Restrictive lung disease (HP:0002091)1.66868337
154J-shaped sella turcica (HP:0002680)1.63254884
155T lymphocytopenia (HP:0005403)1.62828914
156Vasculitis (HP:0002633)1.61186234
157Zonular cataract (HP:0010920)1.60667226
158Abnormality of transition element cation homeostasis (HP:0011030)1.59494379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.19574984
2GRK73.38498413
3ACVR1B3.10842111
4MST43.04865543
5TAOK33.01208078
6DDR22.95961066
7BLK2.71888563
8TBK12.57453609
9TAOK22.54380601
10BCKDK2.54025533
11MST1R2.23537305
12TGFBR22.19573443
13MAP3K142.17045517
14IRAK32.14481064
15FGR2.13541577
16TYK22.10788301
17TAOK12.05504493
18MAP4K11.94186367
19PRPF4B1.89569526
20PIM21.87968570
21NME21.85801946
22CAMKK21.82298733
23IRAK41.72383011
24EPHB11.72140388
25IKBKE1.66794149
26NEK91.66588225
27PBK1.57532566
28IKBKB1.53953622
29KIT1.50422275
30LRRK21.49984878
31ADRBK21.49834407
32FGFR41.47671519
33PIK3CG1.47367233
34JAK31.45034345
35LMTK21.40554971
36WNK41.38349194
37CDC42BPA1.36630056
38RIPK41.35552109
39TESK11.33551805
40TRIB31.32609131
41SIK11.32033059
42EPHA31.30399213
43FRK1.26965118
44MOS1.26126815
45KDR1.25809815
46ZAP701.25187627
47JAK11.23660097
48STK391.23533896
49CSK1.22978467
50BTK1.22789265
51MAP3K31.21735122
52MYLK1.20813529
53OXSR11.18897825
54BMPR21.17980254
55MAP2K21.17831570
56STK101.15020621
57TESK21.12022542
58PTK61.08165634
59CSF1R1.05440331
60MAP2K31.04521898
61ABL21.02505294
62FLT31.01221610
63TEC1.00521981
64EPHB20.98816884
65PRKG20.94391062
66MAP3K110.94217461
67TGFBR10.93214333
68EPHA20.91950368
69MAP3K50.91043023
70NLK0.84283602
71DAPK20.83436528
72JAK20.82967647
73DYRK1B0.78974375
74LYN0.76450462
75FES0.76421426
76CHUK0.76107552
77MARK30.75929819
78GRK60.75826978
79PKN20.75467799
80IRAK10.74286572
81MATK0.72867431
82SYK0.68636903
83TYRO30.68168058
84MET0.68156577
85TRPM70.66645503
86SIK30.65221199
87PIM10.64051281
88HCK0.64021151
89LCK0.63592762
90NUAK10.63325400
91RIPK10.62235178
92CAMK1G0.62022481
93PAK40.61391745
94ITK0.59611702
95CAMK1D0.56554237
96PRKCD0.55327557
97ARAF0.54768235
98TXK0.53807862
99GRK10.53654715
100MAPK150.53607355
101PDGFRA0.53318910
102INSRR0.52381795
103RPS6KA40.49489604
104PIK3CA0.49211606
105PDPK10.47169021
106ABL10.46939166
107BMX0.46736676
108ICK0.46158133
109RPS6KC10.44829281
110RPS6KL10.44829281
111MAP3K130.42496045
112IRAK20.41097628
113LIMK10.40891471
114MAPK40.40282970
115CAMKK10.40139287
116MAP3K10.38439500
117MAPKAPK30.38353214
118MAP2K60.38129395
119RPS6KA20.37848925
120DAPK30.36848340
121PDK20.36082592
122PTK20.35684016
123PRKCQ0.35497423
124PDK10.33229336
125TIE10.33204604
126RPS6KA60.33142338
127CDK60.32836149
128EIF2AK30.31979033
129GSK3A0.31627371
130IGF1R0.31340731
131EGFR0.30865195
132MAPK110.30129232
133MAPK70.27406791
134TNK20.26920837
135CDK40.23213648
136KSR10.22493795
137INSR0.19590532
138FYN0.18854351
139CLK10.18258457
140MAP3K80.17367672

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000402.94734351
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93631489
3Asthma_Homo sapiens_hsa053102.70631654
4Allograft rejection_Homo sapiens_hsa053302.48822908
5Staphylococcus aureus infection_Homo sapiens_hsa051502.47441522
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.22584668
7Sulfur metabolism_Homo sapiens_hsa009202.15910561
8* Other glycan degradation_Homo sapiens_hsa005112.13526023
9Autoimmune thyroid disease_Homo sapiens_hsa053202.07146269
10Fatty acid degradation_Homo sapiens_hsa000712.05702561
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00931576
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.97684291
13Complement and coagulation cascades_Homo sapiens_hsa046101.96281495
14Histidine metabolism_Homo sapiens_hsa003401.95167418
15Tryptophan metabolism_Homo sapiens_hsa003801.89827947
16* Lysosome_Homo sapiens_hsa041421.89812623
17Peroxisome_Homo sapiens_hsa041461.79544599
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76121020
19Type I diabetes mellitus_Homo sapiens_hsa049401.70733124
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62608521
21Salmonella infection_Homo sapiens_hsa051321.61526429
22Chemical carcinogenesis_Homo sapiens_hsa052041.57998405
23Collecting duct acid secretion_Homo sapiens_hsa049661.57411219
24PPAR signaling pathway_Homo sapiens_hsa033201.56786120
25Nitrogen metabolism_Homo sapiens_hsa009101.56537223
26Caffeine metabolism_Homo sapiens_hsa002321.51883985
27beta-Alanine metabolism_Homo sapiens_hsa004101.48347171
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47150797
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45026677
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37994695
31Folate biosynthesis_Homo sapiens_hsa007901.37525300
32Leishmaniasis_Homo sapiens_hsa051401.33177959
33Propanoate metabolism_Homo sapiens_hsa006401.31557629
34Prion diseases_Homo sapiens_hsa050201.30006604
35Starch and sucrose metabolism_Homo sapiens_hsa005001.28670956
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.27433134
37Glutathione metabolism_Homo sapiens_hsa004801.24697984
38Arginine biosynthesis_Homo sapiens_hsa002201.23682945
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.21718422
40Vitamin digestion and absorption_Homo sapiens_hsa049771.21663602
41Retinol metabolism_Homo sapiens_hsa008301.18385890
42Fatty acid metabolism_Homo sapiens_hsa012121.17042339
43Fat digestion and absorption_Homo sapiens_hsa049751.14778823
44Renin-angiotensin system_Homo sapiens_hsa046141.14064568
45Viral myocarditis_Homo sapiens_hsa054161.13307914
46Pertussis_Homo sapiens_hsa051331.10806970
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08539533
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08091448
49Malaria_Homo sapiens_hsa051441.07667416
50Butanoate metabolism_Homo sapiens_hsa006501.06987702
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04927220
52Mineral absorption_Homo sapiens_hsa049781.04567777
53ABC transporters_Homo sapiens_hsa020101.03598733
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.01199269
55Sulfur relay system_Homo sapiens_hsa041221.00992994
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00794098
57B cell receptor signaling pathway_Homo sapiens_hsa046621.00513035
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00123425
59Fatty acid elongation_Homo sapiens_hsa000620.99728488
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98947125
61Steroid biosynthesis_Homo sapiens_hsa001000.98826354
62Vibrio cholerae infection_Homo sapiens_hsa051100.97427158
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96067514
64Legionellosis_Homo sapiens_hsa051340.96059554
65Bile secretion_Homo sapiens_hsa049760.95593674
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94938558
67African trypanosomiasis_Homo sapiens_hsa051430.93254077
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91217673
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.90304915
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.85873655
71Herpes simplex infection_Homo sapiens_hsa051680.85308521
72Selenocompound metabolism_Homo sapiens_hsa004500.85227877
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.84871441
74Sphingolipid metabolism_Homo sapiens_hsa006000.84191791
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82881817
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.82713642
77Shigellosis_Homo sapiens_hsa051310.82599010
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82295265
79Glycerolipid metabolism_Homo sapiens_hsa005610.82176632
80Phenylalanine metabolism_Homo sapiens_hsa003600.81394102
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80966228
82Arginine and proline metabolism_Homo sapiens_hsa003300.80906674
83Bladder cancer_Homo sapiens_hsa052190.80853616
84Rheumatoid arthritis_Homo sapiens_hsa053230.79260920
85Pentose phosphate pathway_Homo sapiens_hsa000300.79092097
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78868445
87Pyruvate metabolism_Homo sapiens_hsa006200.78805704
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77312006
89Osteoclast differentiation_Homo sapiens_hsa043800.77279584
90Tuberculosis_Homo sapiens_hsa051520.76463544
91Galactose metabolism_Homo sapiens_hsa000520.75630854
92Phagosome_Homo sapiens_hsa041450.74749467
93Arachidonic acid metabolism_Homo sapiens_hsa005900.74544872
94Chemokine signaling pathway_Homo sapiens_hsa040620.73354338
95Amoebiasis_Homo sapiens_hsa051460.72690269
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72272198
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71881056
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67500617
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67137869
100Protein export_Homo sapiens_hsa030600.65972119
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.63011815
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.62473380
103Tyrosine metabolism_Homo sapiens_hsa003500.62137026
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61141407
105Hepatitis B_Homo sapiens_hsa051610.61125238
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60878297
107Hematopoietic cell lineage_Homo sapiens_hsa046400.60100200
108Fructose and mannose metabolism_Homo sapiens_hsa000510.58715973
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58703529
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58584333
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.58476120
112Protein digestion and absorption_Homo sapiens_hsa049740.58300185
113Toxoplasmosis_Homo sapiens_hsa051450.58234939
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.57609163
115Carbon metabolism_Homo sapiens_hsa012000.56408597
116Antigen processing and presentation_Homo sapiens_hsa046120.55812981
117Acute myeloid leukemia_Homo sapiens_hsa052210.55196736
118Measles_Homo sapiens_hsa051620.55061385
119Hepatitis C_Homo sapiens_hsa051600.54269663
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50408357
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49518200
122Influenza A_Homo sapiens_hsa051640.48990265
123TNF signaling pathway_Homo sapiens_hsa046680.48756325
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48637573
125T cell receptor signaling pathway_Homo sapiens_hsa046600.48391071
126Graft-versus-host disease_Homo sapiens_hsa053320.47702921
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47598372
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47114057
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46812502
130Synaptic vesicle cycle_Homo sapiens_hsa047210.45755641
131Epstein-Barr virus infection_Homo sapiens_hsa051690.45053889
132Apoptosis_Homo sapiens_hsa042100.44652945
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43947131
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43154092
135Prolactin signaling pathway_Homo sapiens_hsa049170.38860415
136Primary immunodeficiency_Homo sapiens_hsa053400.35521080
137Endocytosis_Homo sapiens_hsa041440.34384433
138Systemic lupus erythematosus_Homo sapiens_hsa053220.30844633
139VEGF signaling pathway_Homo sapiens_hsa043700.29845726
140HIF-1 signaling pathway_Homo sapiens_hsa040660.27587590
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24714941
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.24227393
143Type II diabetes mellitus_Homo sapiens_hsa049300.22421223
144Ether lipid metabolism_Homo sapiens_hsa005650.21616033
145HTLV-I infection_Homo sapiens_hsa051660.15059625
146Platelet activation_Homo sapiens_hsa046110.13785949
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13418813
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11210528
149Renal cell carcinoma_Homo sapiens_hsa052110.08690613
150GnRH signaling pathway_Homo sapiens_hsa049120.08160891
151Insulin resistance_Homo sapiens_hsa049310.06658500

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »