FUCA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)5.99801622
2COPI coating of Golgi vesicle (GO:0048205)5.42809567
3Golgi transport vesicle coating (GO:0048200)5.42809567
4tricarboxylic acid cycle (GO:0006099)5.10521572
5drug transmembrane transport (GO:0006855)4.69383949
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.65451285
7protein retention in ER lumen (GO:0006621)4.61001169
8NADH metabolic process (GO:0006734)4.44961176
9lysine metabolic process (GO:0006553)4.39901601
10lysine catabolic process (GO:0006554)4.39901601
11protein maturation by protein folding (GO:0022417)4.38784503
12organic cation transport (GO:0015695)4.23529467
13urate metabolic process (GO:0046415)4.22432718
14drug transport (GO:0015893)4.17900469
15* glycoside metabolic process (GO:0016137)4.14828842
16tricarboxylic acid metabolic process (GO:0072350)4.08221296
17L-phenylalanine metabolic process (GO:0006558)4.00300967
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.00300967
19toxin transport (GO:1901998)3.88752313
20relaxation of cardiac muscle (GO:0055119)3.85885580
21peptide catabolic process (GO:0043171)3.82588815
22very-low-density lipoprotein particle assembly (GO:0034379)3.73404222
23quaternary ammonium group transport (GO:0015697)3.71500126
24regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.66761314
25phosphate ion transport (GO:0006817)3.65035326
26cell adhesion mediated by integrin (GO:0033627)3.63545189
27succinate metabolic process (GO:0006105)3.63474413
28pyrimidine ribonucleoside catabolic process (GO:0046133)3.63192476
29peptidyl-glutamic acid carboxylation (GO:0017187)3.61317254
30protein carboxylation (GO:0018214)3.61317254
31valine metabolic process (GO:0006573)3.58211620
32regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.49361178
33positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.48857162
34glycosphingolipid catabolic process (GO:0046479)3.38455519
35regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.36767250
36branched-chain amino acid metabolic process (GO:0009081)3.33796146
37oxaloacetate metabolic process (GO:0006107)3.32000072
38negative regulation of fibrinolysis (GO:0051918)3.31159598
392-oxoglutarate metabolic process (GO:0006103)3.30042009
40nucleobase-containing small molecule interconversion (GO:0015949)3.29758585
41pinocytosis (GO:0006907)3.28592389
42oligosaccharide catabolic process (GO:0009313)3.27899470
43renal absorption (GO:0070293)3.23497602
44fibrinolysis (GO:0042730)3.21129492
45energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.20335792
46ATP hydrolysis coupled proton transport (GO:0015991)3.20335792
47sarcomere organization (GO:0045214)3.20044419
48proline biosynthetic process (GO:0006561)3.19352891
49hyaluronan catabolic process (GO:0030214)3.19302479
50phagosome maturation (GO:0090382)3.18604001
51nucleotide-sugar biosynthetic process (GO:0009226)3.17732925
52regulation of relaxation of muscle (GO:1901077)3.17477687
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.17004771
54regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.16810952
55respiratory electron transport chain (GO:0022904)3.16035959
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15165735
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.14647375
58L-phenylalanine catabolic process (GO:0006559)3.14647375
59regulation of actin filament-based movement (GO:1903115)3.13946694
60amino-acid betaine transport (GO:0015838)3.13783605
61carnitine transport (GO:0015879)3.13783605
62aspartate family amino acid catabolic process (GO:0009068)3.13645141
63regulation of fibrinolysis (GO:0051917)3.13217131
64glycolipid catabolic process (GO:0019377)3.12521004
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12284744
66phosphate ion transmembrane transport (GO:0035435)3.12248366
67fatty acid beta-oxidation (GO:0006635)3.10798880
68electron transport chain (GO:0022900)3.09567120
69angiotensin maturation (GO:0002003)3.09161024
70COPII vesicle coating (GO:0048208)3.06556046
71short-chain fatty acid metabolic process (GO:0046459)3.06372905
72heart contraction (GO:0060047)3.02339536
73heart process (GO:0003015)3.02339536
74skin morphogenesis (GO:0043589)3.01659078
75regulation of metalloenzyme activity (GO:0048552)3.00382710
764-hydroxyproline metabolic process (GO:0019471)2.99561781
77regulation of acyl-CoA biosynthetic process (GO:0050812)2.99094619
78retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.98277697
79modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97734028
80modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97734028
81positive regulation by organism of defense response of other organism involved in symbiotic interact2.97734028
82modulation by symbiont of host immune response (GO:0052553)2.97734028
83positive regulation by symbiont of host defense response (GO:0052509)2.97734028
84modulation by symbiont of host defense response (GO:0052031)2.97734028
85nonribosomal peptide biosynthetic process (GO:0019184)2.96736539
86excretion (GO:0007588)2.96674804
87surfactant homeostasis (GO:0043129)2.95105702
88response to thyroid hormone (GO:0097066)2.93483747
89regulation of cholesterol esterification (GO:0010872)2.93177028
90branched-chain amino acid catabolic process (GO:0009083)2.92610022
91plasma lipoprotein particle assembly (GO:0034377)2.91568304
92regulation of protein activation cascade (GO:2000257)2.90041811
93negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.88659437
94apoptotic cell clearance (GO:0043277)2.88226530
95cytidine deamination (GO:0009972)2.87046072
96cytidine metabolic process (GO:0046087)2.87046072
97cytidine catabolic process (GO:0006216)2.87046072
98basement membrane organization (GO:0071711)2.86713281
99regulation of complement activation (GO:0030449)2.83873764
100ATP synthesis coupled proton transport (GO:0015986)2.82427495
101energy coupled proton transport, down electrochemical gradient (GO:0015985)2.82427495
102regulation of cardiac muscle cell contraction (GO:0086004)2.81059809
103NADPH regeneration (GO:0006740)2.80265393
104bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79980806
105regulation of coenzyme metabolic process (GO:0051196)2.78168966
106regulation of cofactor metabolic process (GO:0051193)2.78168966
107carnitine metabolic process (GO:0009437)2.78098228
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77247267
109ribosome assembly (GO:0042255)2.75659413
110peptidyl-proline hydroxylation (GO:0019511)2.74394357
111daunorubicin metabolic process (GO:0044597)2.73870617
112polyketide metabolic process (GO:0030638)2.73870617
113doxorubicin metabolic process (GO:0044598)2.73870617
114glutathione biosynthetic process (GO:0006750)2.73809245
115negative regulation of protein activation cascade (GO:2000258)2.73486604
116regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73464513
117proteasome assembly (GO:0043248)2.73178076
118protein hydroxylation (GO:0018126)2.72854176
119protein-lipid complex assembly (GO:0065005)2.72454088
120cardiac muscle contraction (GO:0060048)2.71674497
121pentose-phosphate shunt (GO:0006098)2.71520446
122oxidative phosphorylation (GO:0006119)2.71513436
123neutrophil activation involved in immune response (GO:0002283)2.70830393
124ceramide catabolic process (GO:0046514)2.68595292
125regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.68528748
126lipid oxidation (GO:0034440)2.67027819
127keratan sulfate catabolic process (GO:0042340)2.66944352
128fatty acid oxidation (GO:0019395)2.66481823
129fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.65446300
130sphingolipid catabolic process (GO:0030149)2.65143947
131transferrin transport (GO:0033572)2.64396523
132regulation of cell communication by electrical coupling (GO:0010649)2.63901337
133glucose 6-phosphate metabolic process (GO:0051156)2.63515263
134protein N-linked glycosylation via asparagine (GO:0018279)2.63087329
135membrane lipid catabolic process (GO:0046466)2.61992106
136peptidyl-asparagine modification (GO:0018196)2.60518884
137response to mercury ion (GO:0046689)2.60414472
138cardiac myofibril assembly (GO:0055003)2.59680485
139cholesterol efflux (GO:0033344)2.59490659
140hydrogen ion transmembrane transport (GO:1902600)2.59379286
141regulation of plasminogen activation (GO:0010755)2.59355017
142histamine transport (GO:0051608)2.58148955
143respiratory burst (GO:0045730)2.57715509
144cell communication involved in cardiac conduction (GO:0086065)2.57095168
145low-density lipoprotein particle clearance (GO:0034383)2.56670993
146fatty acid catabolic process (GO:0009062)2.56547750
147negative regulation of complement activation (GO:0045916)2.56008576
148protein localization to endosome (GO:0036010)2.55763016
149response to host immune response (GO:0052572)2.55509765
150response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55509765
151regulation of interferon-beta biosynthetic process (GO:0045357)2.54835135
152ventricular cardiac muscle cell action potential (GO:0086005)2.54818061
153macrophage activation involved in immune response (GO:0002281)2.54725317
154glutamine family amino acid biosynthetic process (GO:0009084)2.53011779
155establishment of integrated proviral latency (GO:0075713)2.52694157
156hydrogen peroxide catabolic process (GO:0042744)2.52297580
157cellular response to zinc ion (GO:0071294)2.51380838
158negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.50291074
159protein N-linked glycosylation (GO:0006487)2.50020805
160barbed-end actin filament capping (GO:0051016)2.47295559
161membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.46556264
162ferric iron transport (GO:0015682)2.46548582
163trivalent inorganic cation transport (GO:0072512)2.46548582
164metanephric nephron tubule development (GO:0072234)2.46382185
165glucose catabolic process (GO:0006007)2.45912864
166vesicle coating (GO:0006901)2.43634432
167negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.43426844
168regulation of translational termination (GO:0006449)2.42984860
169plasma lipoprotein particle clearance (GO:0034381)2.42331829
170UDP-N-acetylglucosamine metabolic process (GO:0006047)2.42268177
171negative regulation of coagulation (GO:0050819)2.42195429
172activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42008583
173alpha-linolenic acid metabolic process (GO:0036109)2.41055462
174blood coagulation, intrinsic pathway (GO:0007597)2.40827955
175intestinal cholesterol absorption (GO:0030299)2.40070704
176proline metabolic process (GO:0006560)2.39821735
177regulation of apoptotic cell clearance (GO:2000425)2.38335049
178cellular copper ion homeostasis (GO:0006878)2.38164244
179positive regulation of nuclease activity (GO:0032075)2.34589280
180zinc ion transmembrane transport (GO:0071577)2.32931838
181endoplasmic reticulum unfolded protein response (GO:0030968)2.30531791
182negative regulation of blood coagulation (GO:0030195)2.29711347
183negative regulation of hemostasis (GO:1900047)2.29711347
184L-ascorbic acid metabolic process (GO:0019852)2.29475402
185positive regulation of extracellular matrix organization (GO:1903055)2.26143668
186platelet degranulation (GO:0002576)2.24606818
187cellular zinc ion homeostasis (GO:0006882)2.24493071
188nuclear envelope reassembly (GO:0031468)2.24409123
189mitotic nuclear envelope reassembly (GO:0007084)2.24409123
190adhesion of symbiont to host (GO:0044406)2.24180083
191urea cycle (GO:0000050)2.22670166
192cell redox homeostasis (GO:0045454)2.22599727
193lipopolysaccharide biosynthetic process (GO:0009103)2.22032260
194endodermal cell differentiation (GO:0035987)2.21651663
195purine ribonucleotide transport (GO:0015868)2.21280528
196GDP-mannose metabolic process (GO:0019673)2.20733949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.49879839
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.96881244
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.54788998
4E2F7_22180533_ChIP-Seq_HELA_Human3.49863038
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.41623563
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.29076406
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.83751569
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.76302316
9ZNF263_19887448_ChIP-Seq_K562_Human2.72555707
10AR_21909140_ChIP-Seq_LNCAP_Human2.66770832
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.57107569
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.56233279
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46946233
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46919501
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45457633
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.42770060
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.41219221
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34158958
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.32999523
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.22623618
21* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21941857
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21278618
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.20822954
24GATA1_22025678_ChIP-Seq_K562_Human2.20239752
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.18022396
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16758494
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14917716
28EP300_21415370_ChIP-Seq_HL-1_Mouse2.12750832
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11883577
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11795231
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09524682
32RXR_22158963_ChIP-Seq_LIVER_Mouse2.08524770
33MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08262688
34* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.07180659
35E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04635630
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98445572
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.95560130
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94146556
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.89556573
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89461223
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88608755
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87636095
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.82917372
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81578228
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.79680635
46TFEB_21752829_ChIP-Seq_HELA_Human1.79370863
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79264522
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.78820830
49DCP1A_22483619_ChIP-Seq_HELA_Human1.75644327
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75333895
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71976822
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.71412558
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68556941
54SOX2_20726797_ChIP-Seq_SW620_Human1.68174999
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66620665
56* TBX20_22328084_ChIP-Seq_HEART_Mouse1.66613137
57* TBX20_22080862_ChIP-Seq_HEART_Mouse1.66613137
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64191568
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61782408
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60594521
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59619647
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57399962
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55051055
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53198223
65VDR_24787735_ChIP-Seq_THP-1_Human1.50075383
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49974978
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.49839497
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49235712
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.48892896
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48877343
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48002474
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45078714
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.44482583
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.43723646
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43421029
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41959867
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41670106
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39961404
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39412359
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39412359
81GABP_19822575_ChIP-Seq_HepG2_Human1.36752968
82SPI1_23127762_ChIP-Seq_K562_Human1.36655988
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36513010
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35938733
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.35324839
86GABP_17652178_ChIP-ChIP_JURKAT_Human1.34247877
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33206498
88EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.32166110
89EGR1_19032775_ChIP-ChIP_M12_Human1.30924957
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30030563
91ATF3_27146783_Chip-Seq_COLON_Human1.29823999
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.29487900
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28849072
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.28469054
95CDX2_20551321_ChIP-Seq_CACO-2_Human1.28454403
96XRN2_22483619_ChIP-Seq_HELA_Human1.28387653
97SCL_19346495_ChIP-Seq_HPC-7_Human1.28303664
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27688954
99LXR_22158963_ChIP-Seq_LIVER_Mouse1.27271326
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26886920
101CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26742931
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26557205
103* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26470333
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26138774
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24292142
106SOX17_20123909_ChIP-Seq_XEN_Mouse1.23380004
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23097962
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21359143
109GATA2_19941826_ChIP-Seq_K562_Human1.21340970
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20229212
111SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18594941
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18594941
113CJUN_26792858_Chip-Seq_BT549_Human1.18452554
114SPI1_23547873_ChIP-Seq_NB4_Human1.18370445
115RACK7_27058665_Chip-Seq_MCF-7_Human1.18077427
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17363358
117GATA4_25053715_ChIP-Seq_YYC3_Human1.17326004
118STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16489262
119GATA3_26560356_Chip-Seq_TH2_Human1.15844326
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15652296
121FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14590259
122RUNX_20019798_ChIP-Seq_JUKART_Human1.14451173
123SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13973183
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12540418
125* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12378121
126* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11177441
127HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10289685
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10202478
129NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09339486
130TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08385723
131SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08236912
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07732563
133EGR1_19374776_ChIP-ChIP_THP-1_Human1.07721804
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07384529
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06588379
136STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06449570
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06266907
138FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05979338
139CLOCK_20551151_ChIP-Seq_293T_Human1.05844422
140TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.05553553
141GATA1_19941827_ChIP-Seq_MEL_Mouse1.04848525
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04142801
143PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04002578
144* PU_27001747_Chip-Seq_BMDM_Mouse1.03569880
145ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03507115
146ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02638692
147NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02281242
148ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01376963
149SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99988262
150VDR_24763502_ChIP-Seq_THP-1_Human0.98536571
151THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97029949
152TTF2_22483619_ChIP-Seq_HELA_Human0.96391592
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95814066
154MYB_26560356_Chip-Seq_TH2_Human0.95663526
155MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95499677
156GATA1_19941826_ChIP-Seq_K562_Human0.93576042
157E2F1_21310950_ChIP-Seq_MCF-7_Human0.93528479
158VDR_22108803_ChIP-Seq_LS180_Human0.92680823
159FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92506844
160CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92068665
161PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91790716
162CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89465985
163RUNX1_22412390_ChIP-Seq_EML_Mouse0.88680814
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88318449
165TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88291403
166AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88235195
167RXR_22108803_ChIP-Seq_LS180_Human0.88065872
168CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87756027
169MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.87101941
170SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86735142
171CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85691564
172* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85111691
173TP63_23658742_ChIP-Seq_EP156T_Human0.85039224
174SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84168920
175JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83973031
176P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83930952
177* GATA3_27048872_Chip-Seq_THYMUS_Human0.83097079
178KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81964482
179PIAS1_25552417_ChIP-Seq_VCAP_Human0.79959666
180ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79423242
181SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79134694
182GATA6_25053715_ChIP-Seq_YYC3_Human0.78919579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation4.54196051
2MP0008438_abnormal_cutaneous_collagen4.24507770
3MP0002837_dystrophic_cardiac_calcinosis3.90570034
4MP0005058_abnormal_lysosome_morphology3.68508806
5MP0003646_muscle_fatigue3.42758221
6MP0002139_abnormal_hepatobiliary_system3.40880717
7MP0004084_abnormal_cardiac_muscle3.36983354
8MP0009840_abnormal_foam_cell3.27913567
9MP0004272_abnormal_basement_membrane3.20733222
10MP0003183_abnormal_peptide_metabolism2.82317687
11MP0005257_abnormal_intraocular_pressure2.71671093
12MP0004215_abnormal_myocardial_fiber2.63741379
13MP0009643_abnormal_urine_homeostasis2.50217320
14MP0000751_myopathy2.49045154
15MP0001765_abnormal_ion_homeostasis2.47861153
16MP0002877_abnormal_melanocyte_morpholog2.43150263
17MP0003806_abnormal_nucleotide_metabolis2.39952906
18MP0005332_abnormal_amino_acid2.30404541
19MP0003705_abnormal_hypodermis_morpholog2.28152880
20MP0001958_emphysema2.27470609
21MP0005365_abnormal_bile_salt2.24985264
22MP0004036_abnormal_muscle_relaxation2.22114714
23MP0003195_calcinosis2.20123035
24MP0005451_abnormal_body_composition2.10059801
25MP0003172_abnormal_lysosome_physiology2.08941149
26MP0005360_urolithiasis2.08095409
27MP0004484_altered_response_of2.06280825
28MP0001756_abnormal_urination2.05824617
29MP0002972_abnormal_cardiac_muscle2.01280915
30MP0005330_cardiomyopathy1.95827471
31MP0010352_gastrointestinal_tract_polyps1.95338547
32MP0002136_abnormal_kidney_physiology1.93049984
33MP0004019_abnormal_vitamin_homeostasis1.89835806
34MP0008775_abnormal_heart_ventricle1.84254377
35MP0000343_altered_response_to1.83457914
36MP0005636_abnormal_mineral_homeostasis1.80641176
37MP0005408_hypopigmentation1.80124700
38MP0010234_abnormal_vibrissa_follicle1.78798562
39MP0003941_abnormal_skin_development1.75032327
40MP0009697_abnormal_copulation1.69921402
41MP0006036_abnormal_mitochondrial_physio1.67362161
42MP0003950_abnormal_plasma_membrane1.64280912
43MP0004147_increased_porphyrin_level1.64068235
44MP0001835_abnormal_antigen_presentation1.63683218
45MP0003191_abnormal_cellular_cholesterol1.56805082
46MP0003300_gastrointestinal_ulcer1.52768603
47MP0003828_pulmonary_edema1.52737041
48MP0003436_decreased_susceptibility_to1.51716650
49MP0003878_abnormal_ear_physiology1.49347602
50MP0005377_hearing/vestibular/ear_phenot1.49347602
51MP0002138_abnormal_hepatobiliary_system1.46533801
52MP0010368_abnormal_lymphatic_system1.46521858
53MP0000538_abnormal_urinary_bladder1.46171806
54MP0000749_muscle_degeneration1.45484470
55MP0002254_reproductive_system_inflammat1.45051303
56MP0000230_abnormal_systemic_arterial1.44521558
57MP0005165_increased_susceptibility_to1.43692834
58MP0001915_intracranial_hemorrhage1.42041701
59MP0002148_abnormal_hypersensitivity_rea1.41186294
60MP0002419_abnormal_innate_immunity1.40629362
61MP0005023_abnormal_wound_healing1.39865782
62MP0005085_abnormal_gallbladder_physiolo1.39750461
63MP0001544_abnormal_cardiovascular_syste1.37689958
64MP0005385_cardiovascular_system_phenoty1.37689958
65MP0003724_increased_susceptibility_to1.36946179
66MP0008007_abnormal_cellular_replicative1.34802283
67MP0004957_abnormal_blastocyst_morpholog1.33719656
68MP0006082_CNS_inflammation1.33547492
69MP0009785_altered_susceptibility_to1.29846927
70MP0008932_abnormal_embryonic_tissue1.29748924
71MP0004130_abnormal_muscle_cell1.29406314
72MP0005620_abnormal_muscle_contractility1.26367824
73MP0010386_abnormal_urinary_bladder1.25181019
74MP0003186_abnormal_redox_activity1.23914329
75MP0000858_altered_metastatic_potential1.21585600
76MP0008004_abnormal_stomach_pH1.19214102
77MP0001661_extended_life_span1.18762642
78MP0002060_abnormal_skin_morphology1.18394485
79MP0003868_abnormal_feces_composition1.16864916
80MP0002295_abnormal_pulmonary_circulatio1.16671065
81MP0005584_abnormal_enzyme/coenzyme_acti1.14918912
82MP0009764_decreased_sensitivity_to1.14259232
83MP0003111_abnormal_nucleus_morphology1.13328305
84MP0002876_abnormal_thyroid_physiology1.10925037
85MP0004087_abnormal_muscle_fiber1.09202508
86MP0000358_abnormal_cell_content/1.06950848
87MP0009780_abnormal_chondrocyte_physiolo1.06618203
88MP0010329_abnormal_lipoprotein_level1.05961229
89MP0002090_abnormal_vision1.05805424
90MP0003693_abnormal_embryo_hatching1.05756427
91MP0001533_abnormal_skeleton_physiology1.05545334
92MP0004510_myositis1.03799942
93MP0004233_abnormal_muscle_weight1.03716074
94MP0005025_abnormal_response_to1.03636114
95MP0008469_abnormal_protein_level1.02675256
96MP0000750_abnormal_muscle_regeneration1.02565781
97MP0003303_peritoneal_inflammation1.02333014
98MP0002896_abnormal_bone_mineralization1.01975727
99MP0000609_abnormal_liver_physiology1.01935977
100MP0005319_abnormal_enzyme/_coenzyme1.01813703
101MP0010630_abnormal_cardiac_muscle1.01778230
102MP0003221_abnormal_cardiomyocyte_apopto1.01757297
103MP0003075_altered_response_to1.01594187
104MP0006138_congestive_heart_failure1.01445173
105MP0008260_abnormal_autophagy1.00780607
106MP0005000_abnormal_immune_tolerance1.00493030
107MP0002998_abnormal_bone_remodeling1.00205454
108MP0005623_abnormal_meninges_morphology0.99632964
109MP0005535_abnormal_body_temperature0.99085683
110MP0005166_decreased_susceptibility_to0.97234418
111MP0005310_abnormal_salivary_gland0.97089832
112MP0003137_abnormal_impulse_conducting0.96998053
113MP0001845_abnormal_inflammatory_respons0.96318616
114MP0001243_abnormal_dermal_layer0.96313602
115MP0005167_abnormal_blood-brain_barrier0.95076648
116MP0001730_embryonic_growth_arrest0.94519140
117MP0003866_abnormal_defecation0.94304765
118MP0008875_abnormal_xenobiotic_pharmacok0.94132617
119MP0005197_abnormal_uvea_morphology0.92722494
120MP0004085_abnormal_heartbeat0.92444999
121MP0005084_abnormal_gallbladder_morpholo0.90040205
122MP0000747_muscle_weakness0.89703096
123MP0002909_abnormal_adrenal_gland0.88691041
124MP0001542_abnormal_bone_strength0.88668849
125MP0001853_heart_inflammation0.88251146
126MP0001849_ear_inflammation0.87204339
127MP0001663_abnormal_digestive_system0.86047557
128MP0003566_abnormal_cell_adhesion0.84956836
129MP0001666_abnormal_nutrient_absorption0.84796082
130MP0006054_spinal_hemorrhage0.84234752
131MP0009384_cardiac_valve_regurgitation0.84027221
132MP0003091_abnormal_cell_migration0.82527073
133MP0003453_abnormal_keratinocyte_physiol0.82524260
134MP0010094_abnormal_chromosome_stability0.81910143
135MP0005464_abnormal_platelet_physiology0.81091028
136MP0002332_abnormal_exercise_endurance0.80783956
137MP0005164_abnormal_response_to0.80732449
138MP0010030_abnormal_orbit_morphology0.79659290
139MP0001790_abnormal_immune_system0.79014040
140MP0005387_immune_system_phenotype0.79014040
141MP0010307_abnormal_tumor_latency0.77133020
142MP0003795_abnormal_bone_structure0.76633131
143MP0004264_abnormal_extraembryonic_tissu0.76554007
144MP0000598_abnormal_liver_morphology0.76547660
145MP0001764_abnormal_homeostasis0.76179613
146MP0000767_abnormal_smooth_muscle0.75609001
147MP0003656_abnormal_erythrocyte_physiolo0.75414014
148MP0003638_abnormal_response/metabolism_0.74818705
149MP0004782_abnormal_surfactant_physiolog0.74812238
150MP0000604_amyloidosis0.74652512
151MP0003279_aneurysm0.73967265
152MP0004858_abnormal_nervous_system0.73668018
153MP0000003_abnormal_adipose_tissue0.73042475
154MP0001664_abnormal_digestion0.72566271
155MP0002452_abnormal_antigen_presenting0.72482019
156MP0002933_joint_inflammation0.72223961
157MP0002135_abnormal_kidney_morphology0.71790767
158MP0002106_abnormal_muscle_physiology0.70889998
159MP0003718_maternal_effect0.69763430
160MP0002089_abnormal_postnatal_growth/wei0.69274209
161MP0003045_fibrosis0.69033869
162MP0000371_diluted_coat_color0.68900316
163MP0002938_white_spotting0.67476554
164MP0005501_abnormal_skin_physiology0.66911839
165MP0003984_embryonic_growth_retardation0.66386182
166MP0003077_abnormal_cell_cycle0.66234367
167MP0001881_abnormal_mammary_gland0.65355990
168MP0001672_abnormal_embryogenesis/_devel0.65289265
169MP0005380_embryogenesis_phenotype0.65289265
170MP0005384_cellular_phenotype0.64897714
171MP0001697_abnormal_embryo_size0.64852814
172MP0002080_prenatal_lethality0.64815718
173MP0005275_abnormal_skin_tensile0.63741638
174MP0005508_abnormal_skeleton_morphology0.63413034

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.96589385
2Hyperactive renin-angiotensin system (HP:0000841)4.81677592
3Increased circulating renin level (HP:0000848)4.57552930
4Metabolic alkalosis (HP:0200114)4.44324240
5Vacuolated lymphocytes (HP:0001922)4.38139475
6Hypokalemic alkalosis (HP:0001949)4.36678415
7Abnormality of chloride homeostasis (HP:0011422)4.33743040
8Hypomagnesemia (HP:0002917)4.29404275
9Vertebral compression fractures (HP:0002953)4.11277298
10Gout (HP:0001997)4.10512407
11Polyuria (HP:0000103)4.09566871
12Proximal tubulopathy (HP:0000114)4.00565863
13Abnormal urine output (HP:0012590)3.93275000
14Abnormality of renal excretion (HP:0011036)3.88689304
15Abnormality of magnesium homeostasis (HP:0004921)3.87466228
16Protrusio acetabuli (HP:0003179)3.85089891
17Deep venous thrombosis (HP:0002625)3.80508866
18Generalized aminoaciduria (HP:0002909)3.55339689
19Dysostosis multiplex (HP:0000943)3.54602914
20Abnormal drinking behavior (HP:0030082)3.45133442
21Polydipsia (HP:0001959)3.45133442
22Tetany (HP:0001281)3.37921675
23Hyperaldosteronism (HP:0000859)3.37326086
24Abnormality of renin-angiotensin system (HP:0000847)3.36725670
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.34782086
26Ketoacidosis (HP:0001993)3.33483798
27Mucopolysacchariduria (HP:0008155)3.20770518
28Urinary glycosaminoglycan excretion (HP:0003541)3.20770518
29Sudden death (HP:0001699)3.11110864
30Abnormality of mucopolysaccharide metabolism (HP:0011020)2.98321506
31Abnormality of polysaccharide metabolism (HP:0011012)2.98321506
32Abnormality of glycosaminoglycan metabolism (HP:0004371)2.98321506
33Abnormality of fatty-acid metabolism (HP:0004359)2.96727563
34Ventricular tachycardia (HP:0004756)2.94646977
35Increased cerebral lipofuscin (HP:0011813)2.93534082
36Increased purine levels (HP:0004368)2.93223874
37Hyperuricemia (HP:0002149)2.93223874
38Cardiovascular calcification (HP:0011915)2.91375104
39Renal salt wasting (HP:0000127)2.89581774
40Increased serum pyruvate (HP:0003542)2.89455539
41Systemic lupus erythematosus (HP:0002725)2.88205463
42Palpitations (HP:0001962)2.88107067
43Glycosuria (HP:0003076)2.87605922
44Abnormality of urine glucose concentration (HP:0011016)2.87605922
45Abnormality of glycolysis (HP:0004366)2.86562616
46Myocardial infarction (HP:0001658)2.86391424
47Vascular calcification (HP:0004934)2.84162437
48Hypobetalipoproteinemia (HP:0003563)2.82613593
49Xanthomatosis (HP:0000991)2.78337159
50Asymmetric septal hypertrophy (HP:0001670)2.75221910
51Intrahepatic cholestasis (HP:0001406)2.73685445
52Abnormality of glycolipid metabolism (HP:0010969)2.71203479
53Abnormality of liposaccharide metabolism (HP:0010968)2.71203479
54Abnormality of glycosphingolipid metabolism (HP:0004343)2.71203479
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.70349394
56Cervical subluxation (HP:0003308)2.66594085
57Abnormality of purine metabolism (HP:0004352)2.66451526
58Orthostatic hypotension (HP:0001278)2.63749783
59Hepatic necrosis (HP:0002605)2.63677737
60Mitral stenosis (HP:0001718)2.62946047
61Abnormality of macrophages (HP:0004311)2.61882385
62Atrial fibrillation (HP:0005110)2.58945395
63Right ventricular cardiomyopathy (HP:0011663)2.56722333
64Exercise-induced muscle cramps (HP:0003710)2.56596460
65Axonal loss (HP:0003447)2.53957683
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53781465
67Prolonged partial thromboplastin time (HP:0003645)2.51785417
68Abnormality of the common coagulation pathway (HP:0010990)2.50624897
69Abnormality of glutamine family amino acid metabolism (HP:0010902)2.50213854
70Hyperglycinuria (HP:0003108)2.48845433
71Syncope (HP:0001279)2.47821694
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.47318998
73Hypercalciuria (HP:0002150)2.46035213
74Complement deficiency (HP:0004431)2.45577465
75Recurrent abscess formation (HP:0002722)2.44917275
76Hypolipoproteinemia (HP:0010981)2.44417351
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44401537
78Dicarboxylic aciduria (HP:0003215)2.44401537
79Hypokalemia (HP:0002900)2.43975381
80Metaphyseal cupping (HP:0003021)2.41948961
81Cholecystitis (HP:0001082)2.41589042
82Abnormal gallbladder physiology (HP:0012438)2.41589042
83Osteolytic defects of the hand bones (HP:0009699)2.41193383
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.41193383
85Primary atrial arrhythmia (HP:0001692)2.40798247
86Nuclear cataract (HP:0100018)2.40559879
87Abnormality of complement system (HP:0005339)2.39811341
88Alkalosis (HP:0001948)2.39192399
89Abnormal mitochondria in muscle tissue (HP:0008316)2.39178385
90J-shaped sella turcica (HP:0002680)2.38680171
91Muscle fiber splitting (HP:0003555)2.35393199
92Hydroxyprolinuria (HP:0003080)2.34798527
93Abnormality of proline metabolism (HP:0010907)2.34798527
94Nausea (HP:0002018)2.34342811
95Supraventricular tachycardia (HP:0004755)2.32707489
96Neoplasm of head and neck (HP:0012288)2.30791646
97Esophageal neoplasm (HP:0100751)2.30791646
98Prolonged neonatal jaundice (HP:0006579)2.30731270
99Ankle contracture (HP:0006466)2.29384159
100Abnormality of the Achilles tendon (HP:0005109)2.29297215
101Hepatocellular necrosis (HP:0001404)2.28478403
102Abnormal delivery (HP:0001787)2.27940817
103Acute encephalopathy (HP:0006846)2.27675820
104Short nail (HP:0001799)2.26454369
105Abnormality of the acetabulum (HP:0003170)2.26266599
106Supraventricular arrhythmia (HP:0005115)2.25681772
107Glomerulonephritis (HP:0000099)2.22644742
108Hyperphosphaturia (HP:0003109)2.21055434
109Mitochondrial inheritance (HP:0001427)2.20913412
110Acute necrotizing encephalopathy (HP:0006965)2.20566240
111Lipoatrophy (HP:0100578)2.20281954
112Progressive neurologic deterioration (HP:0002344)2.19709348
113Ketosis (HP:0001946)2.19177691
114Eczematoid dermatitis (HP:0000976)2.18863966
115Loss of speech (HP:0002371)2.18500590
116Abnormality of dentin (HP:0010299)2.16907788
117Calf muscle hypertrophy (HP:0008981)2.16338356
118Nonimmune hydrops fetalis (HP:0001790)2.15792973
119Myoglobinuria (HP:0002913)2.15124599
120Abnormality of carpal bone ossification (HP:0006257)2.13716179
121Flat acetabular roof (HP:0003180)2.13484249
122Renal tubular acidosis (HP:0001947)2.13478849
123Abnormality of the umbilical cord (HP:0010881)2.13382152
124Type I transferrin isoform profile (HP:0003642)2.10980459
125Ovoid vertebral bodies (HP:0003300)2.09768788
126Abnormality of the calf musculature (HP:0001430)2.08969080
127Abnormal urine phosphate concentration (HP:0012599)2.08012499
128Skin nodule (HP:0200036)2.07994500
129Reduced antithrombin III activity (HP:0001976)2.06221816
130Hypoalphalipoproteinemia (HP:0003233)2.05331313
131Hypercholesterolemia (HP:0003124)2.05147467
132Dilated cardiomyopathy (HP:0001644)2.04812064
133Achilles tendon contracture (HP:0001771)2.04465442
134Abnormality of the intrinsic pathway (HP:0010989)2.03225381
135Pheochromocytoma (HP:0002666)2.01794291
136Wormian bones (HP:0002645)2.01375298
137Increased muscle lipid content (HP:0009058)2.00440903
138Vomiting (HP:0002013)2.00146730
139Neuroendocrine neoplasm (HP:0100634)2.00050821
140Increased CSF lactate (HP:0002490)1.99727975
141Methylmalonic aciduria (HP:0012120)1.99557191
142Interstitial pulmonary disease (HP:0006530)1.99019493
143Conjunctival hamartoma (HP:0100780)1.98577743
144Conjugated hyperbilirubinemia (HP:0002908)1.97945140
145Beaking of vertebral bodies (HP:0004568)1.97192465
146Respiratory failure (HP:0002878)1.97040281
147Hypokinesia (HP:0002375)1.96521267
148Decreased circulating renin level (HP:0003351)1.96378490
149Tetraparesis (HP:0002273)1.95039370
150Abnormality of potassium homeostasis (HP:0011042)1.94907427
151Distal lower limb muscle weakness (HP:0009053)1.94424000
152Metabolic acidosis (HP:0001942)1.93918504
153Abnormality of renal resorption (HP:0011038)1.93857475
154Soft skin (HP:0000977)1.90836520
155Blue sclerae (HP:0000592)1.90607761
156Elbow flexion contracture (HP:0002987)1.89984316
157Joint hemorrhage (HP:0005261)1.89233457
158Amyloidosis (HP:0011034)1.88603528
159Hypoglycemic coma (HP:0001325)1.88146938
160Abnormality of the fetal cardiovascular system (HP:0010948)1.87715170
161Abnormal umbilical cord blood vessels (HP:0011403)1.87715170
162Single umbilical artery (HP:0001195)1.87715170
163Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87686566
164Fat malabsorption (HP:0002630)1.85903214
165Back pain (HP:0003418)1.84371917
166Hyperammonemia (HP:0001987)1.81590789
167Cerebral aneurysm (HP:0004944)1.75261999
168Abnormality of the distal phalanges of the toes (HP:0010182)1.74698595
169Aortic dissection (HP:0002647)1.74185866
170Generalized amyotrophy (HP:0003700)1.73644776
171Purpura (HP:0000979)1.72978873
172Abnormal protein glycosylation (HP:0012346)1.71110902
173Abnormal glycosylation (HP:0012345)1.71110902
174Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71110902
175Abnormal protein N-linked glycosylation (HP:0012347)1.71110902
176Entropion (HP:0000621)1.70487615
177Upper limb amyotrophy (HP:0009129)1.69065489
178Distal upper limb amyotrophy (HP:0007149)1.69065489
179Cardiomegaly (HP:0001640)1.68571031
180Microglossia (HP:0000171)1.67530955
181Spinal rigidity (HP:0003306)1.66619067
182Abnormal ossification of hand bones (HP:0005921)1.66432484
183Rough bone trabeculation (HP:0100670)1.65724108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.22881345
2WNK33.95278015
3OXSR13.66489825
4MYLK2.97969164
5TESK12.85818149
6LMTK22.73495368
7EIF2AK12.59046797
8LIMK12.52024789
9PBK2.45896419
10MST42.44641950
11EPHA22.43352900
12PDK42.35304261
13PDK32.35304261
14TTN2.30865643
15BUB12.28450370
16PDK22.22721633
17GRK72.22459493
18BCKDK2.13840312
19STK392.09074066
20TGFBR21.94851639
21TESK21.77232256
22MAP3K121.74875095
23MAP3K31.67978971
24STK241.63624362
25NEK11.63481382
26TIE11.58787430
27ERBB41.57113841
28LATS21.54850870
29ERN11.52815940
30IRAK31.51042810
31KIT1.50121206
32EIF2AK31.49206534
33MET1.47594712
34PDGFRA1.47503816
35TTK1.44383929
36PKN21.43938995
37PTK21.40675108
38PHKG11.38556971
39PHKG21.38556971
40TBK11.33030311
41RIPK41.29790027
42NME21.29342357
43DDR21.29246186
44VRK21.29100927
45NEK91.28317581
46TRPM71.24099871
47SRPK11.23851625
48FRK1.23396358
49ICK1.18040653
50KDR1.16667015
51FGFR41.16451885
52MAP3K141.14272993
53IRAK41.14180687
54TYK21.10161973
55STK161.10054494
56WNK11.09959107
57BLK1.09134185
58LATS11.06662719
59MST1R1.03630851
60MAPKAPK31.00545711
61PIM21.00312782
62RIPK10.98315127
63MAP4K10.98007243
64ARAF0.96829709
65TAOK20.96461064
66MAP3K80.96050258
67SMG10.95119034
68CAMKK20.93735048
69MOS0.93264486
70LRRK20.93043805
71TRIB30.90225153
72MATK0.90024408
73STK38L0.88419791
74EPHB10.88178623
75SGK30.87386739
76TAOK30.85870316
77FLT30.85145219
78SGK20.84486673
79PLK30.83659842
80PAK20.83595735
81MAP2K30.83582703
82ZAP700.81678139
83SGK2230.81666344
84SGK4940.81666344
85JAK10.80024993
86TEC0.78595367
87BRSK10.78038817
88DMPK0.77139544
89PRKG20.76038915
90ILK0.74279454
91CSNK1G30.74267930
92CDK80.74229958
93CAMK2D0.72567866
94PIK3CA0.71566155
95CDK60.69761013
96CDK70.69269167
97PINK10.66660329
98STK30.66392454
99BMX0.65892597
100CLK10.64542881
101BTK0.64167897
102BRSK20.63900933
103STK40.63882807
104SCYL20.63489990
105RPS6KC10.63344663
106RPS6KL10.63344663
107RPS6KA60.62577790
108PRKCD0.61596524
109CSNK1A1L0.60769948
110SYK0.60272006
111CSF1R0.60191264
112TSSK60.59851837
113PLK10.59807949
114AURKB0.58529792
115NTRK10.57418629
116PRKCE0.57345434
117PAK40.56475149
118OBSCN0.55782063
119CSNK1G10.55042226
120PAK10.54313634
121PDPK10.53981695
122STK380.53882351
123GRK60.53563262
124RPS6KA20.52206712
125PAK30.50312991
126WEE10.49283178
127MAPK120.48847110
128PTK60.48737271
129CHEK20.47748350
130FES0.47173602
131STK100.47084698
132INSRR0.46417707
133PDK10.46158582
134TXK0.45068255
135DAPK30.44734899
136FER0.43563981
137AKT20.43111241
138DAPK10.42855548
139GRK50.42801426
140NEK20.42771941
141PRKD10.42721164
142PIK3CG0.42464594
143SIK10.41921421
144MAP3K50.41735362
145JAK20.41587823
146AURKA0.41484583
147RPS6KB20.41319794
148PTK2B0.41176418
149ERBB30.40184232
150EPHB20.40032851
151MAPKAPK50.39302840
152FGFR10.39187222
153ITK0.38683501
154CDC70.38672505
155MAP3K10.37827492
156ABL20.37540379
157ROCK10.36659508
158GSK3A0.35936323
159MAP3K20.35483621
160EEF2K0.34908967
161CAMK40.34029517
162CSNK2A10.33993282
163LYN0.33577432
164MUSK0.33346746
165CDK140.33164152
166CDK180.33145133
167MAP3K110.32929017

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.70018556
2Collecting duct acid secretion_Homo sapiens_hsa049663.04723400
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.01100951
4Oxidative phosphorylation_Homo sapiens_hsa001902.90943871
5Propanoate metabolism_Homo sapiens_hsa006402.63531946
6* Other glycan degradation_Homo sapiens_hsa005112.49556913
7Lysosome_Homo sapiens_hsa041422.47861178
8Proteasome_Homo sapiens_hsa030502.46499198
9Complement and coagulation cascades_Homo sapiens_hsa046102.38245785
10Parkinsons disease_Homo sapiens_hsa050122.30090014
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22158574
12Fatty acid degradation_Homo sapiens_hsa000712.10369818
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.06286402
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.92707279
15Butanoate metabolism_Homo sapiens_hsa006501.87231973
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83631185
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75760371
18Pyruvate metabolism_Homo sapiens_hsa006201.74618881
19Carbon metabolism_Homo sapiens_hsa012001.69375335
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67485039
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67346888
22Cardiac muscle contraction_Homo sapiens_hsa042601.67298639
23Alzheimers disease_Homo sapiens_hsa050101.66008874
24Steroid biosynthesis_Homo sapiens_hsa001001.64355312
25Renin-angiotensin system_Homo sapiens_hsa046141.63172090
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.60325734
27Sulfur metabolism_Homo sapiens_hsa009201.57271161
28Vibrio cholerae infection_Homo sapiens_hsa051101.55650510
29Vitamin B6 metabolism_Homo sapiens_hsa007501.53841330
30Mineral absorption_Homo sapiens_hsa049781.49757963
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48308527
32Rheumatoid arthritis_Homo sapiens_hsa053231.42281357
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41589695
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39729846
35Phagosome_Homo sapiens_hsa041451.35335636
36Arginine biosynthesis_Homo sapiens_hsa002201.34344867
37Fatty acid metabolism_Homo sapiens_hsa012121.34018125
38Protein digestion and absorption_Homo sapiens_hsa049741.31784272
39Folate biosynthesis_Homo sapiens_hsa007901.31368124
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30548790
41Peroxisome_Homo sapiens_hsa041461.30365194
42DNA replication_Homo sapiens_hsa030301.29082524
43beta-Alanine metabolism_Homo sapiens_hsa004101.23842533
44Starch and sucrose metabolism_Homo sapiens_hsa005001.20648836
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.19306044
46Vitamin digestion and absorption_Homo sapiens_hsa049771.18302294
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.17969265
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15727592
49Sulfur relay system_Homo sapiens_hsa041221.13794379
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11832751
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11806659
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11330825
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10943009
54Glutathione metabolism_Homo sapiens_hsa004801.10669312
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09704425
56Fat digestion and absorption_Homo sapiens_hsa049751.08340452
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06901166
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06232883
59Dilated cardiomyopathy_Homo sapiens_hsa054141.05614345
60Tyrosine metabolism_Homo sapiens_hsa003501.05289870
61Huntingtons disease_Homo sapiens_hsa050161.04999311
62Galactose metabolism_Homo sapiens_hsa000521.02485496
63One carbon pool by folate_Homo sapiens_hsa006701.00766721
64Fructose and mannose metabolism_Homo sapiens_hsa000510.99819198
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.99371134
66Leishmaniasis_Homo sapiens_hsa051400.96615043
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95828626
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94028103
69Mismatch repair_Homo sapiens_hsa034300.92366903
70Tuberculosis_Homo sapiens_hsa051520.92304359
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91411272
72Pyrimidine metabolism_Homo sapiens_hsa002400.91231474
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88349106
74Synaptic vesicle cycle_Homo sapiens_hsa047210.87080679
75Sphingolipid metabolism_Homo sapiens_hsa006000.86394954
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.86383499
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84953245
78Bladder cancer_Homo sapiens_hsa052190.84134609
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82028689
80Arginine and proline metabolism_Homo sapiens_hsa003300.80355703
81Tryptophan metabolism_Homo sapiens_hsa003800.79780073
82Legionellosis_Homo sapiens_hsa051340.79669752
83ECM-receptor interaction_Homo sapiens_hsa045120.78751464
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.74794383
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74702937
86Chemical carcinogenesis_Homo sapiens_hsa052040.74347198
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73084862
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70416316
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69984567
90Gastric acid secretion_Homo sapiens_hsa049710.69623666
91Base excision repair_Homo sapiens_hsa034100.68719899
92Nucleotide excision repair_Homo sapiens_hsa034200.68482396
93Retinol metabolism_Homo sapiens_hsa008300.67225936
94Fatty acid elongation_Homo sapiens_hsa000620.66197106
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65216841
96Prion diseases_Homo sapiens_hsa050200.62350078
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61303048
98Pancreatic secretion_Homo sapiens_hsa049720.60588287
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60139270
100Osteoclast differentiation_Homo sapiens_hsa043800.59885711
101Viral myocarditis_Homo sapiens_hsa054160.59485482
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57901329
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57132775
104Salmonella infection_Homo sapiens_hsa051320.56999857
105Non-homologous end-joining_Homo sapiens_hsa034500.55163259
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53446767
107Pertussis_Homo sapiens_hsa051330.53074926
108Thyroid hormone synthesis_Homo sapiens_hsa049180.53053814
109Shigellosis_Homo sapiens_hsa051310.52857985
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52167859
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52160158
112Caffeine metabolism_Homo sapiens_hsa002320.52055558
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.51645423
114RNA transport_Homo sapiens_hsa030130.50406034
115Arachidonic acid metabolism_Homo sapiens_hsa005900.49269622
116Toxoplasmosis_Homo sapiens_hsa051450.48794523
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47896483
118Proteoglycans in cancer_Homo sapiens_hsa052050.47519707
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46460323
120Selenocompound metabolism_Homo sapiens_hsa004500.46126554
121PPAR signaling pathway_Homo sapiens_hsa033200.45755801
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44584527
123Bile secretion_Homo sapiens_hsa049760.43765008
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42893257
125Metabolic pathways_Homo sapiens_hsa011000.41768838
126Protein export_Homo sapiens_hsa030600.40535407
127Cell cycle_Homo sapiens_hsa041100.40056578
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39390795
129Glycerolipid metabolism_Homo sapiens_hsa005610.38844566
130Pentose phosphate pathway_Homo sapiens_hsa000300.37067066
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.36309143
132Focal adhesion_Homo sapiens_hsa045100.35641443
133Malaria_Homo sapiens_hsa051440.35207580
134Hematopoietic cell lineage_Homo sapiens_hsa046400.34951142
135Small cell lung cancer_Homo sapiens_hsa052220.34289155
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34058293
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33535078
138Histidine metabolism_Homo sapiens_hsa003400.32913144
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.31497363
140Spliceosome_Homo sapiens_hsa030400.31075511
141Phenylalanine metabolism_Homo sapiens_hsa003600.29705452
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29446458
143Insulin resistance_Homo sapiens_hsa049310.28231537
144Amoebiasis_Homo sapiens_hsa051460.27734422
145Antigen processing and presentation_Homo sapiens_hsa046120.25508661
146N-Glycan biosynthesis_Homo sapiens_hsa005100.24873828
147Renin secretion_Homo sapiens_hsa049240.23348210
148Biosynthesis of amino acids_Homo sapiens_hsa012300.22171890
149HIF-1 signaling pathway_Homo sapiens_hsa040660.22070837
150Lysine degradation_Homo sapiens_hsa003100.21608472

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