FUK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)4.16797214
2regulation of posttranscriptional gene silencing (GO:0060147)4.02992458
3regulation of gene silencing by miRNA (GO:0060964)4.02992458
4regulation of gene silencing by RNA (GO:0060966)4.02992458
5glycine metabolic process (GO:0006544)3.91936149
6regulation of translational fidelity (GO:0006450)3.80009990
7mitotic G1 DNA damage checkpoint (GO:0031571)3.72498055
8regulation of gamma-delta T cell differentiation (GO:0045586)3.67675123
9sulfur amino acid catabolic process (GO:0000098)3.66696326
10regulation of cholesterol homeostasis (GO:2000188)3.63608653
11regulation of hippo signaling (GO:0035330)3.58220380
12positive regulation of histone deacetylation (GO:0031065)3.53370106
13heterochromatin organization (GO:0070828)3.51508494
14regulation of gamma-delta T cell activation (GO:0046643)3.51255162
15regulation of translational termination (GO:0006449)3.48697904
16negative regulation of sterol transport (GO:0032372)3.46324293
17negative regulation of cholesterol transport (GO:0032375)3.46324293
18dicarboxylic acid biosynthetic process (GO:0043650)3.43845168
19maternal placenta development (GO:0001893)3.41304356
20positive regulation of gamma-delta T cell activation (GO:0046645)3.39992971
21pre-miRNA processing (GO:0031054)3.37856561
22serine family amino acid catabolic process (GO:0009071)3.36562241
23folic acid metabolic process (GO:0046655)3.35870731
24opioid receptor signaling pathway (GO:0038003)3.34025069
25positive regulation of CREB transcription factor activity (GO:0032793)3.33867335
26tolerance induction (GO:0002507)3.32683183
27rRNA catabolic process (GO:0016075)3.32114851
28fucose catabolic process (GO:0019317)3.29284908
29L-fucose metabolic process (GO:0042354)3.29284908
30L-fucose catabolic process (GO:0042355)3.29284908
31mannose metabolic process (GO:0006013)3.25384533
32lysine metabolic process (GO:0006553)3.23789092
33lysine catabolic process (GO:0006554)3.23789092
34N-acetylneuraminate metabolic process (GO:0006054)3.23559811
35serine family amino acid metabolic process (GO:0009069)3.21152969
36mitotic G1/S transition checkpoint (GO:0044819)3.19199206
37protein localization to kinetochore (GO:0034501)3.17247605
38cysteine metabolic process (GO:0006534)3.16192319
39serine family amino acid biosynthetic process (GO:0009070)3.13736364
40drug catabolic process (GO:0042737)3.10532370
41negative regulation of cAMP-mediated signaling (GO:0043951)3.06381513
42proline biosynthetic process (GO:0006561)3.05449204
43fatty acid homeostasis (GO:0055089)3.04079415
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.01547771
45glutathione biosynthetic process (GO:0006750)3.00908173
46focal adhesion assembly (GO:0048041)3.00197304
47cell-substrate adherens junction assembly (GO:0007045)3.00197304
48cellular response to epidermal growth factor stimulus (GO:0071364)2.99617942
49positive regulation of protein deacetylation (GO:0090312)2.99049345
50positive regulation of SMAD protein import into nucleus (GO:0060391)2.98963266
51fucosylation (GO:0036065)2.97443467
52adherens junction assembly (GO:0034333)2.97233013
53nuclear pore organization (GO:0006999)2.95118501
54cellular ketone body metabolic process (GO:0046950)2.94886243
55negative regulation of cell size (GO:0045792)2.94238725
56nuclear pore complex assembly (GO:0051292)2.94113952
57pentose-phosphate shunt (GO:0006098)2.92799243
58urea metabolic process (GO:0019627)2.92437361
59urea cycle (GO:0000050)2.92437361
60tetrahydrofolate metabolic process (GO:0046653)2.89786461
61one-carbon metabolic process (GO:0006730)2.89601079
62DNA unwinding involved in DNA replication (GO:0006268)2.87245247
63cell-substrate junction assembly (GO:0007044)2.86891970
64establishment of apical/basal cell polarity (GO:0035089)2.85866551
65antigen processing and presentation of endogenous antigen (GO:0019883)2.82655750
66homocysteine metabolic process (GO:0050667)2.82156186
67exogenous drug catabolic process (GO:0042738)2.81775425
68intestinal absorption (GO:0050892)2.81749148
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.81649543
70peptidyl-lysine dimethylation (GO:0018027)2.80695180
71G1 DNA damage checkpoint (GO:0044783)2.80391951
72cellular modified amino acid catabolic process (GO:0042219)2.80058724
73positive regulation of triglyceride biosynthetic process (GO:0010867)2.78294765
74apoptotic process involved in morphogenesis (GO:0060561)2.77997066
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.76899436
76L-phenylalanine metabolic process (GO:0006558)2.76643591
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.76643591
78negative regulation of histone methylation (GO:0031061)2.75478601
79paraxial mesoderm development (GO:0048339)2.75134484
80intestinal cholesterol absorption (GO:0030299)2.72971879
81nonribosomal peptide biosynthetic process (GO:0019184)2.72638220
82regulation of fatty acid beta-oxidation (GO:0031998)2.70380496
83triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.70303037
84macroautophagy (GO:0016236)2.70198740
85lysosome organization (GO:0007040)2.69858785
86lytic vacuole organization (GO:0080171)2.69858785
87regulation of triglyceride biosynthetic process (GO:0010866)2.69066830
88regulation of sister chromatid cohesion (GO:0007063)2.68226846
89kynurenine metabolic process (GO:0070189)2.66780813
90ketone body metabolic process (GO:1902224)2.64962525
91protein K11-linked deubiquitination (GO:0035871)2.64039358
92glyoxylate metabolic process (GO:0046487)2.63846793
93positive regulation of catenin import into nucleus (GO:0035413)2.63348393
944-hydroxyproline metabolic process (GO:0019471)2.62868451
95sulfate transmembrane transport (GO:1902358)2.62798301
96anterior/posterior axis specification, embryo (GO:0008595)2.62700388
97L-alpha-amino acid transmembrane transport (GO:1902475)2.62425274
98phosphatidylethanolamine biosynthetic process (GO:0006646)2.61921449
99hemidesmosome assembly (GO:0031581)2.61749089
100regulation of SMAD protein import into nucleus (GO:0060390)2.61513498
101interferon-gamma secretion (GO:0072643)2.61388728
102protein localization to endosome (GO:0036010)2.60772444
103positive regulation of T cell mediated cytotoxicity (GO:0001916)2.60564890
104negative regulation of fatty acid biosynthetic process (GO:0045717)2.59704841
105negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.58034013
106mitotic nuclear envelope disassembly (GO:0007077)2.57975310
107cytoskeletal anchoring at plasma membrane (GO:0007016)2.57908603
108tryptophan catabolic process (GO:0006569)2.57688831
109indole-containing compound catabolic process (GO:0042436)2.57688831
110indolalkylamine catabolic process (GO:0046218)2.57688831
111T-helper cell differentiation (GO:0042093)2.57251213
112CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.57251213
113positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56679354
114regulation of memory T cell differentiation (GO:0043380)2.56442977
115ethanol oxidation (GO:0006069)2.55514678
116amino-acid betaine metabolic process (GO:0006577)2.55443261
117nitrogen cycle metabolic process (GO:0071941)2.55305157
118negative regulation of cell killing (GO:0031342)2.55263074
119negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.55263074
120epithelial cell differentiation involved in prostate gland development (GO:0060742)2.54477269
121thymic T cell selection (GO:0045061)2.54052186
122DNA duplex unwinding (GO:0032508)2.53929399
123DNA geometric change (GO:0032392)2.53587766
124regulation of histone H3-K9 methylation (GO:0051570)2.53442925
125negative regulation of fibrinolysis (GO:0051918)2.52984733
126positive regulation of defense response to virus by host (GO:0002230)2.52922767
127alpha-linolenic acid metabolic process (GO:0036109)2.52754511
128IMP biosynthetic process (GO:0006188)2.52552530
129zinc ion homeostasis (GO:0055069)2.51824945
130carnitine shuttle (GO:0006853)2.51539498
131protein localization to chromosome, centromeric region (GO:0071459)2.51209922
132T cell selection (GO:0045058)2.50752378
133phosphatidylethanolamine metabolic process (GO:0046337)2.50577059
134folic acid-containing compound metabolic process (GO:0006760)2.49631320
135glutamate metabolic process (GO:0006536)2.49271170
136negative regulation of cell fate specification (GO:0009996)2.49269199
137S-adenosylmethionine metabolic process (GO:0046500)2.48819420
138phosphate ion transmembrane transport (GO:0035435)2.48508426
139cellular response to ATP (GO:0071318)2.48224511
140CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.47903702
141regulation of T cell mediated cytotoxicity (GO:0001914)2.47892156
142positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.47184383
143L-serine metabolic process (GO:0006563)2.46260698
144trophectodermal cell differentiation (GO:0001829)2.46157263
145nodal signaling pathway (GO:0038092)2.46136484
146negative regulation of TOR signaling (GO:0032007)2.46079922
147glutamine family amino acid biosynthetic process (GO:0009084)2.46062484
148blood vessel endothelial cell migration (GO:0043534)2.45807922
149aspartate family amino acid catabolic process (GO:0009068)2.45597953
150erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.45507422
151L-phenylalanine catabolic process (GO:0006559)2.45507422
152negative regulation of lipid transport (GO:0032369)2.45165518
153chromatin assembly (GO:0031497)2.45101087
154labyrinthine layer blood vessel development (GO:0060716)2.44315639
155ncRNA catabolic process (GO:0034661)2.44006736
156regulation of triglyceride catabolic process (GO:0010896)2.43765435
157positive thymic T cell selection (GO:0045059)2.41848998
158alkaloid metabolic process (GO:0009820)2.40413104
159positive regulation of triglyceride metabolic process (GO:0090208)2.39715376
160basic amino acid transport (GO:0015802)2.39042343
161negative thymic T cell selection (GO:0045060)2.38854086
162peptide biosynthetic process (GO:0043043)2.37896795
163phosphatidylglycerol biosynthetic process (GO:0006655)2.37009170
164cellular response to exogenous dsRNA (GO:0071360)2.36048006
165negative T cell selection (GO:0043383)2.35625137
166response to pheromone (GO:0019236)2.34975564
167amino sugar catabolic process (GO:0046348)2.34175625
168positive T cell selection (GO:0043368)2.30983100
169oxidative demethylation (GO:0070989)2.28239635
170alpha-beta T cell differentiation involved in immune response (GO:0002293)2.27633165
171alpha-beta T cell activation involved in immune response (GO:0002287)2.27633165
172T cell differentiation involved in immune response (GO:0002292)2.27633165
173cytochrome complex assembly (GO:0017004)2.24998306
174striated muscle atrophy (GO:0014891)2.24769757
175regulation of defense response to virus by host (GO:0050691)2.24741666
176indolalkylamine metabolic process (GO:0006586)2.24578948
177regulation of triglyceride metabolic process (GO:0090207)2.24417615
178negative regulation of protein oligomerization (GO:0032460)2.24360931
179protein targeting to lysosome (GO:0006622)2.23948349
180establishment of protein localization to vacuole (GO:0072666)2.23948349
181protein targeting to vacuole (GO:0006623)2.23948349
182preassembly of GPI anchor in ER membrane (GO:0016254)2.23875766
183response to misfolded protein (GO:0051788)2.23147111
184tryptophan metabolic process (GO:0006568)2.22236285
185flavonoid metabolic process (GO:0009812)2.20999045
186positive regulation of antigen processing and presentation (GO:0002579)2.20795042
187respiratory chain complex IV assembly (GO:0008535)2.19659774
188axoneme assembly (GO:0035082)2.18518182
189NAD biosynthetic process (GO:0009435)2.18487256
190protein kinase C signaling (GO:0070528)2.18436229
191Peyers patch development (GO:0048541)2.18379071
192mucosal-associated lymphoid tissue development (GO:0048537)2.18379071
193regulation of hydrogen peroxide metabolic process (GO:0010310)2.18327013
194organelle membrane fusion (GO:0090174)2.18279315
195organic cation transport (GO:0015695)2.17887046
196negative regulation of innate immune response (GO:0045824)2.17696416
197purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.17384746
1983-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.17384746
199nucleotide transmembrane transport (GO:1901679)2.17104712
200positive regulation of protein kinase C signaling (GO:0090037)2.16910552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.03149804
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.86456743
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.71387785
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.62096932
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.21566895
6ZNF263_19887448_ChIP-Seq_K562_Human3.00261934
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.70333573
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.67455139
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.60471540
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.58916557
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48756381
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.31162930
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.30668653
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29284708
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.29051569
16MYC_22102868_ChIP-Seq_BL_Human2.28117428
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24938690
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.22225147
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16406219
20* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14594014
21* BCL6_27268052_Chip-Seq_Bcells_Human2.03101255
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02429420
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01781487
24* BCOR_27268052_Chip-Seq_Bcells_Human2.00365305
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99143031
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92803797
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.89928064
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.86998915
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.86963597
30DROSHA_22980978_ChIP-Seq_HELA_Human1.86962829
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84191402
32ELF1_20517297_ChIP-Seq_JURKAT_Human1.81819709
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.78529903
34* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.77422029
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76498924
36RACK7_27058665_Chip-Seq_MCF-7_Human1.74898205
37* E2F1_20622854_ChIP-Seq_HELA_Human1.69925917
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.69411774
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68945450
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.68379314
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68098931
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67372002
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.67269410
44* PHF8_20622854_ChIP-Seq_HELA_Human1.66122370
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65744955
46ATF3_27146783_Chip-Seq_COLON_Human1.65684768
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64708635
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62841204
49MAF_26560356_Chip-Seq_TH2_Human1.62514609
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62362358
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62362358
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62362358
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62244862
54CLOCK_20551151_ChIP-Seq_293T_Human1.60798830
55SCL_19346495_ChIP-Seq_HPC-7_Human1.59871081
56ZNF274_21170338_ChIP-Seq_K562_Hela1.59559414
57LXR_22292898_ChIP-Seq_THP-1_Human1.59550396
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.58560974
59AR_21909140_ChIP-Seq_LNCAP_Human1.57785457
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57505196
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55788862
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.55584086
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55256548
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55159988
65* ERA_21632823_ChIP-Seq_H3396_Human1.54363118
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53734162
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51473323
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50553614
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50422228
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50063732
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47582513
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45171332
73* P300_27268052_Chip-Seq_Bcells_Human1.45036988
74KDM2B_26808549_Chip-Seq_DND41_Human1.44073234
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41147259
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.40713574
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39961533
78MAF_26560356_Chip-Seq_TH1_Human1.39942040
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39518314
80VDR_21846776_ChIP-Seq_THP-1_Human1.39351476
81* SA1_27219007_Chip-Seq_Bcells_Human1.38854502
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36484701
83VDR_24763502_ChIP-Seq_THP-1_Human1.35414825
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34938471
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34554980
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34149170
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34005136
88* RAC3_21632823_ChIP-Seq_H3396_Human1.33945699
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33120670
90SMC4_20622854_ChIP-Seq_HELA_Human1.32893059
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32344777
92TCF7_22412390_ChIP-Seq_EML_Mouse1.32064372
93XRN2_22483619_ChIP-Seq_HELA_Human1.31813145
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30577820
95RARB_24833708_ChIP-Seq_LIVER_Mouse1.30546614
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30531909
97OCT4_20526341_ChIP-Seq_ESCs_Human1.30181380
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29158598
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29117739
100MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29008587
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28652734
102GATA6_25053715_ChIP-Seq_YYC3_Human1.28384982
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.26779281
104* TET1_21451524_ChIP-Seq_MESCs_Mouse1.26449048
105CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26374609
106* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26212385
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25965339
108IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25850873
109* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25297397
110E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25272289
111GATA1_19941827_ChIP-Seq_MEL_Mouse1.25199048
112TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24717925
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24487432
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23924107
115P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23622195
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23428683
117* SA1_27219007_Chip-Seq_ERYTHROID_Human1.22920071
118CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22819944
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21826098
120UTX_26944678_Chip-Seq_JUKART_Human1.20974382
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20824113
122TP63_22573176_ChIP-Seq_HFKS_Human1.20778209
123KDM5A_27292631_Chip-Seq_BREAST_Human1.20311085
124CREB1_26743006_Chip-Seq_LNCaP_Human1.19809869
125RUNX1_22412390_ChIP-Seq_EML_Mouse1.19797336
126STAT1_20625510_ChIP-Seq_HELA_Human1.17757755
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17262445
128CTCF_20526341_ChIP-Seq_ESCs_Human1.17219078
129CHD1_26751641_Chip-Seq_LNCaP_Human1.16860968
130TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16722489
131TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16716259
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16709598
133SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16694381
134MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16628921
135OCT4_19829295_ChIP-Seq_ESCs_Human1.16589986
136NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16231686
137CTCF_27219007_Chip-Seq_Bcells_Human1.14444024
138* TAF2_19829295_ChIP-Seq_ESCs_Human1.14425350
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13871622
140RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13843300
141OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13189128
142E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12992121
143GATA1_19941826_ChIP-Seq_K562_Human1.12989292
144SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12718312
145CTCF_26484167_Chip-Seq_Bcells_Mouse1.11030580
146SPI1_23127762_ChIP-Seq_K562_Human1.10495615
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09535819
148NCOR1_26117541_ChIP-Seq_K562_Human1.09076376
149CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07360470
150RUNX1_27514584_Chip-Seq_MCF-7_Human1.06357663
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05957593
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05867658
153DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05598485
154NANOG_21062744_ChIP-ChIP_HESCs_Human1.05366048
155POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05268247
156BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.05196516
157GATA3_27048872_Chip-Seq_THYMUS_Human1.05020644
158* P68_20966046_ChIP-Seq_HELA_Human1.04112784
159GATA3_26560356_Chip-Seq_TH2_Human1.03517955
160ESR1_20079471_ChIP-ChIP_T-47D_Human1.03062911
161CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02698630
162SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02593855
163NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02050250
164P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.01912027
165* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01561172
166UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00846399
167* YY1_22570637_ChIP-Seq_MALME-3M_Human1.00817224
168KDM2B_26808549_Chip-Seq_K562_Human1.00503515
169IRF8_27001747_Chip-Seq_BMDM_Mouse0.99493718
170MYB_26560356_Chip-Seq_TH1_Human0.99484467
171SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99313004
172TP53_22127205_ChIP-Seq_IMR90_Human0.99275675
173ESR2_21235772_ChIP-Seq_MCF-7_Human0.99192325
174SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98899584
175EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98896819
176KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98588647
177FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98531590
178ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98140935
179SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97949789
180EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97466333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.67787043
2MP0005360_urolithiasis4.32420385
3MP0010234_abnormal_vibrissa_follicle3.70335307
4MP0010352_gastrointestinal_tract_polyps3.47786114
5MP0003172_abnormal_lysosome_physiology3.30049255
6MP0002139_abnormal_hepatobiliary_system3.23939064
7MP0000537_abnormal_urethra_morphology2.66293073
8MP0005085_abnormal_gallbladder_physiolo2.57070927
9MP0001873_stomach_inflammation2.57044816
10MP0005365_abnormal_bile_salt2.49700543
11MP0003806_abnormal_nucleotide_metabolis2.43119011
12MP0005075_abnormal_melanosome_morpholog2.39253782
13MP0005174_abnormal_tail_pigmentation2.36397460
14MP0001986_abnormal_taste_sensitivity2.33903913
15MP0003252_abnormal_bile_duct2.23340300
16MP0000015_abnormal_ear_pigmentation2.20983620
17MP0004043_abnormal_pH_regulation2.19847433
18MP0005058_abnormal_lysosome_morphology2.14647053
19MP0004381_abnormal_hair_follicle2.13379660
20MP0003183_abnormal_peptide_metabolism2.10566591
21MP0001849_ear_inflammation2.05615157
22MP0009840_abnormal_foam_cell2.05086767
23MP0009053_abnormal_anal_canal2.03407274
24MP0004264_abnormal_extraembryonic_tissu2.01685958
25MP0000685_abnormal_immune_system2.01053215
26MP0005076_abnormal_cell_differentiation1.96244796
27MP0002876_abnormal_thyroid_physiology1.93254390
28MP0002653_abnormal_ependyma_morphology1.91843711
29MP0005310_abnormal_salivary_gland1.90715418
30MP0008875_abnormal_xenobiotic_pharmacok1.89218556
31MP0002254_reproductive_system_inflammat1.89158579
32MP0003693_abnormal_embryo_hatching1.87330231
33MP0004957_abnormal_blastocyst_morpholog1.86407764
34MP0010307_abnormal_tumor_latency1.86318126
35MP0001790_abnormal_immune_system1.81413912
36MP0005387_immune_system_phenotype1.81413912
37MP0005671_abnormal_response_to1.80087231
38MP0001730_embryonic_growth_arrest1.79515932
39MP0001666_abnormal_nutrient_absorption1.78669611
40MP0003283_abnormal_digestive_organ1.78608565
41MP0003195_calcinosis1.78346529
42MP0010030_abnormal_orbit_morphology1.77812780
43MP0008872_abnormal_physiological_respon1.76059254
44MP0003763_abnormal_thymus_physiology1.72725364
45MP0010329_abnormal_lipoprotein_level1.71490075
46MP0003436_decreased_susceptibility_to1.68859078
47MP0001835_abnormal_antigen_presentation1.67734738
48MP0001800_abnormal_humoral_immune1.67296766
49MP0000371_diluted_coat_color1.58279956
50MP0003119_abnormal_digestive_system1.57920410
51MP0003566_abnormal_cell_adhesion1.56752337
52MP0003111_abnormal_nucleus_morphology1.55897332
53MP0003303_peritoneal_inflammation1.51454904
54MP0005025_abnormal_response_to1.46542448
55MP0004197_abnormal_fetal_growth/weight/1.44940642
56MP0005023_abnormal_wound_healing1.42837721
57MP0002723_abnormal_immune_serum1.40320461
58MP0008995_early_reproductive_senescence1.36623734
59MP0002084_abnormal_developmental_patter1.36250910
60MP0002086_abnormal_extraembryonic_tissu1.35874750
61MP0001765_abnormal_ion_homeostasis1.34826168
62MP0008961_abnormal_basal_metabolism1.33825698
63MP0001764_abnormal_homeostasis1.33812351
64MP0003045_fibrosis1.33723323
65MP0005083_abnormal_biliary_tract1.33579656
66MP0001672_abnormal_embryogenesis/_devel1.31087646
67MP0005380_embryogenesis_phenotype1.31087646
68MP0002796_impaired_skin_barrier1.30977755
69MP0001501_abnormal_sleep_pattern1.30323475
70MP0005670_abnormal_white_adipose1.29706876
71MP0005000_abnormal_immune_tolerance1.29228031
72MP0004185_abnormal_adipocyte_glucose1.29194253
73MP0010155_abnormal_intestine_physiology1.28887927
74MP0005332_abnormal_amino_acid1.28313638
75MP0001819_abnormal_immune_cell1.28230931
76MP0002420_abnormal_adaptive_immunity1.26507830
77MP0001697_abnormal_embryo_size1.26062183
78MP0000013_abnormal_adipose_tissue1.25793481
79MP0002085_abnormal_embryonic_tissue1.25560834
80MP0003300_gastrointestinal_ulcer1.25424510
81MP0005501_abnormal_skin_physiology1.25413906
82MP0003724_increased_susceptibility_to1.24878427
83MP0000427_abnormal_hair_cycle1.24689429
84MP0002452_abnormal_antigen_presenting1.23488018
85MP0002088_abnormal_embryonic_growth/wei1.21097537
86MP0002166_altered_tumor_susceptibility1.20880937
87MP0003984_embryonic_growth_retardation1.20875763
88MP0000350_abnormal_cell_proliferation1.20474456
89MP0005551_abnormal_eye_electrophysiolog1.19866584
90MP0002693_abnormal_pancreas_physiology1.19316739
91MP0001968_abnormal_touch/_nociception1.17717477
92MP0009785_altered_susceptibility_to1.17590340
93MP0001502_abnormal_circadian_rhythm1.17277061
94MP0002419_abnormal_innate_immunity1.16585576
95MP0002132_abnormal_respiratory_system1.16139705
96MP0000569_abnormal_digit_pigmentation1.15466754
97MP0003646_muscle_fatigue1.14823194
98MP0009333_abnormal_splenocyte_physiolog1.14751338
99MP0003077_abnormal_cell_cycle1.14282803
100MP0003115_abnormal_respiratory_system1.14220846
101MP0003866_abnormal_defecation1.12486289
102MP0002060_abnormal_skin_morphology1.11960182
103MP0002148_abnormal_hypersensitivity_rea1.11004837
104MP0002933_joint_inflammation1.10505713
105MP0005645_abnormal_hypothalamus_physiol1.10108987
106MP0002080_prenatal_lethality1.09060017
107MP0001663_abnormal_digestive_system1.08246019
108MP0001293_anophthalmia1.08062468
109MP0000609_abnormal_liver_physiology1.07763109
110MP0002877_abnormal_melanocyte_morpholog1.07752495
111MP0010094_abnormal_chromosome_stability1.06609796
112MP0003453_abnormal_keratinocyte_physiol1.06050610
113MP0001845_abnormal_inflammatory_respons1.03709304
114MP0005167_abnormal_blood-brain_barrier1.02533254
115MP0000467_abnormal_esophagus_morphology1.01976751
116MP0005666_abnormal_adipose_tissue1.00469320
117MP0004133_heterotaxia0.99437718
118MP0000477_abnormal_intestine_morphology0.98609233
119MP0003123_paternal_imprinting0.98268642
120MP0003890_abnormal_embryonic-extraembry0.98237190
121MP0002136_abnormal_kidney_physiology0.97949334
122MP0005187_abnormal_penis_morphology0.96899889
123MP0008469_abnormal_protein_level0.96808662
124MP0000716_abnormal_immune_system0.96525733
125MP0004233_abnormal_muscle_weight0.96336718
126MP0001664_abnormal_digestion0.95846049
127MP0002089_abnormal_postnatal_growth/wei0.94641389
128MP0002092_abnormal_eye_morphology0.94512568
129MP0002138_abnormal_hepatobiliary_system0.93701669
130MP0005248_abnormal_Harderian_gland0.93382999
131MP0008438_abnormal_cutaneous_collagen0.93038755
132MP0005636_abnormal_mineral_homeostasis0.92733867
133MP0000538_abnormal_urinary_bladder0.91374253
134MP0000003_abnormal_adipose_tissue0.90503801
135MP0002269_muscular_atrophy0.90340850
136MP0005319_abnormal_enzyme/_coenzyme0.90305421
137MP0004019_abnormal_vitamin_homeostasis0.90185790
138MP0002405_respiratory_system_inflammati0.88867753
139MP0009643_abnormal_urine_homeostasis0.88836875
140MP0005375_adipose_tissue_phenotype0.88189390
141MP0002111_abnormal_tail_morphology0.88023227
142MP0006036_abnormal_mitochondrial_physio0.85368016
143MP0003786_premature_aging0.85204852
144MP0004147_increased_porphyrin_level0.84504805
145MP0000383_abnormal_hair_follicle0.84255527
146MP0009384_cardiac_valve_regurgitation0.83899177
147MP0002697_abnormal_eye_size0.83462971
148MP0003091_abnormal_cell_migration0.83202103
149MP0000678_abnormal_parathyroid_gland0.82970845
150MP0005535_abnormal_body_temperature0.82345256
151MP0002234_abnormal_pharynx_morphology0.81928283
152MP0002075_abnormal_coat/hair_pigmentati0.81309998
153MP0000470_abnormal_stomach_morphology0.78967474
154MP0005623_abnormal_meninges_morphology0.78551930
155MP0002398_abnormal_bone_marrow0.78347727
156MP0000377_abnormal_hair_follicle0.77694552
157MP0001944_abnormal_pancreas_morphology0.77043880
158MP0006082_CNS_inflammation0.76336969
159MP0002078_abnormal_glucose_homeostasis0.76122522
160MP0005266_abnormal_metabolism0.75867783
161MP0001919_abnormal_reproductive_system0.75446568
162MP0010368_abnormal_lymphatic_system0.74533261
163MP0000490_abnormal_crypts_of0.73425642
164MP0002009_preneoplasia0.72712233
165MP0000598_abnormal_liver_morphology0.71492271
166MP0001915_intracranial_hemorrhage0.71329336
167MP0001216_abnormal_epidermal_layer0.70810350
168MP0005220_abnormal_exocrine_pancreas0.70491810
169MP0008770_decreased_survivor_rate0.69104569
170MP0003315_abnormal_perineum_morphology0.68727329
171MP0005499_abnormal_olfactory_system0.68517202
172MP0005394_taste/olfaction_phenotype0.68517202
173MP0001756_abnormal_urination0.66373407
174MP0009278_abnormal_bone_marrow0.64448282
175MP0000733_abnormal_muscle_development0.63547358
176MP0002118_abnormal_lipid_homeostasis0.63423321
177MP0003567_abnormal_fetal_cardiomyocyte0.61471956
178MP0002925_abnormal_cardiovascular_devel0.58449092
179MP0003191_abnormal_cellular_cholesterol0.57925723

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.90826727
2Increased neuronal autofluorescent lipopigment (HP:0002074)3.84343213
3Congenital stationary night blindness (HP:0007642)3.65129080
4Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.50124972
5Deep venous thrombosis (HP:0002625)3.40747557
6Abnormality of the lower motor neuron (HP:0002366)3.36258059
7Increased cerebral lipofuscin (HP:0011813)3.31553925
8Pseudobulbar signs (HP:0002200)3.19725703
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.17051920
10Pustule (HP:0200039)3.11886499
11Albinism (HP:0001022)3.11304441
12Abnormality of mucopolysaccharide metabolism (HP:0011020)3.04978610
13Abnormality of polysaccharide metabolism (HP:0011012)3.04978610
14Abnormality of glycosaminoglycan metabolism (HP:0004371)3.04978610
15Spastic diplegia (HP:0001264)3.02438425
16Hand muscle atrophy (HP:0009130)2.98233936
17Xanthomatosis (HP:0000991)2.93869153
18Cerebral aneurysm (HP:0004944)2.90109559
19Dysostosis multiplex (HP:0000943)2.87229746
20Stomatitis (HP:0010280)2.85904377
21Abnormality of the astrocytes (HP:0100707)2.81850163
22Astrocytoma (HP:0009592)2.81850163
23Mucopolysacchariduria (HP:0008155)2.81454496
24Urinary glycosaminoglycan excretion (HP:0003541)2.81454496
25Hypobetalipoproteinemia (HP:0003563)2.78617205
26Upper limb amyotrophy (HP:0009129)2.73704795
27Distal upper limb amyotrophy (HP:0007149)2.73704795
28Decreased circulating renin level (HP:0003351)2.67675122
29Hyperacusis (HP:0010780)2.65018121
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.64852831
31Tubular atrophy (HP:0000092)2.63775665
32Enlarged epiphyses (HP:0010580)2.63663327
33Recurrent fungal infections (HP:0002841)2.60466492
34Myositis (HP:0100614)2.59444773
35Ketosis (HP:0001946)2.56668536
36Mesangial abnormality (HP:0001966)2.55968295
37Angiofibromas (HP:0010615)2.55229576
38Adenoma sebaceum (HP:0009720)2.55229576
39Hematochezia (HP:0002573)2.54225455
40Retrobulbar optic neuritis (HP:0100654)2.53545682
41Optic neuritis (HP:0100653)2.53545682
42Abnormality of the Achilles tendon (HP:0005109)2.51223353
43Adactyly (HP:0009776)2.51210833
44Attenuation of retinal blood vessels (HP:0007843)2.50978797
45Abnormality of T cell physiology (HP:0011840)2.50252112
46Ketoacidosis (HP:0001993)2.49568300
47Right ventricular cardiomyopathy (HP:0011663)2.48955037
48Intrahepatic cholestasis (HP:0001406)2.48333770
49Biliary tract neoplasm (HP:0100574)2.47636828
50Orchitis (HP:0100796)2.46467678
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.43841872
52Basal cell carcinoma (HP:0002671)2.42176363
53Abnormal biliary tract physiology (HP:0012439)2.41927002
54Bile duct proliferation (HP:0001408)2.41927002
55Hyperglycinuria (HP:0003108)2.38650762
56Hyperventilation (HP:0002883)2.36959132
57Severe visual impairment (HP:0001141)2.35748319
58Lymphangioma (HP:0100764)2.33798398
59Ocular albinism (HP:0001107)2.33621343
60Abnormality of proline metabolism (HP:0010907)2.33439697
61Hydroxyprolinuria (HP:0003080)2.33439697
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.32825446
63Abnormality of B cell number (HP:0010975)2.32308420
64Achilles tendon contracture (HP:0001771)2.29994614
65J-shaped sella turcica (HP:0002680)2.28653937
66Hypochromic anemia (HP:0001931)2.25868302
67Ulnar bowing (HP:0003031)2.25840088
68Aneurysm (HP:0002617)2.25248337
69Hyperammonemia (HP:0001987)2.25057391
70Hyperglycinemia (HP:0002154)2.22494455
71Colon cancer (HP:0003003)2.21595115
72Abnormality of the renal cortex (HP:0011035)2.21404507
73Turricephaly (HP:0000262)2.19687308
74Stridor (HP:0010307)2.19525026
75Hypoalbuminemia (HP:0003073)2.18922369
76Abnormal albumin level (HP:0012116)2.18922369
77Shallow orbits (HP:0000586)2.18655993
78Genu recurvatum (HP:0002816)2.17926874
79Eczematoid dermatitis (HP:0000976)2.17923731
80Gout (HP:0001997)2.17707968
81Renovascular hypertension (HP:0100817)2.17391889
82Abnormal rod and cone electroretinograms (HP:0008323)2.17381441
83Abnormality of pyrimidine metabolism (HP:0004353)2.15183721
84Malnutrition (HP:0004395)2.14815620
85IgG deficiency (HP:0004315)2.11256593
86Recurrent cutaneous fungal infections (HP:0011370)2.11071199
87Chronic mucocutaneous candidiasis (HP:0002728)2.11071199
88Nephronophthisis (HP:0000090)2.10690894
89Reticulocytosis (HP:0001923)2.09787738
90Vacuolated lymphocytes (HP:0001922)2.09449030
91Elfin facies (HP:0004428)2.07331832
92Abnormality of transition element cation homeostasis (HP:0011030)2.07288077
93Panhypogammaglobulinemia (HP:0003139)2.06928530
94Hypolipoproteinemia (HP:0010981)2.06307412
95Abnormality of serine family amino acid metabolism (HP:0010894)2.05350735
96Abnormality of glycine metabolism (HP:0010895)2.05350735
97Abnormal drinking behavior (HP:0030082)2.04153260
98Polydipsia (HP:0001959)2.04153260
99Short phalanx of the thumb (HP:0009660)2.03877735
100Mitral valve prolapse (HP:0001634)2.03766458
101Hemoptysis (HP:0002105)2.02650423
102Neoplasm of striated muscle (HP:0009728)2.02625842
103Elevated erythrocyte sedimentation rate (HP:0003565)2.02578597
104Milia (HP:0001056)2.00960751
105Shawl scrotum (HP:0000049)2.00412696
106Alkalosis (HP:0001948)1.99075503
107Esophageal varix (HP:0002040)1.97811626
108Abnormality of the renal medulla (HP:0100957)1.97631125
109Congenital sensorineural hearing impairment (HP:0008527)1.96701958
110Mediastinal lymphadenopathy (HP:0100721)1.96554882
111Ankle contracture (HP:0006466)1.96511902
112Dicarboxylic aciduria (HP:0003215)1.95932720
113Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95932720
114Clumsiness (HP:0002312)1.94812065
115Renal duplication (HP:0000075)1.94442326
116Pancreatic cysts (HP:0001737)1.94121348
117Insomnia (HP:0100785)1.93055789
118Amelogenesis imperfecta (HP:0000705)1.92913221
119Fibroma (HP:0010614)1.92387260
120Protrusio acetabuli (HP:0003179)1.92207859
121Large for gestational age (HP:0001520)1.91633652
122Selective tooth agenesis (HP:0001592)1.91583274
123Glioma (HP:0009733)1.90444334
124Anal stenosis (HP:0002025)1.90158218
125Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.90144868
126Short 1st metacarpal (HP:0010034)1.90144868
127Recurrent bacterial skin infections (HP:0005406)1.88557968
128Ankyloglossia (HP:0010296)1.88550060
129Recurrent sinusitis (HP:0011108)1.88043385
130Flat acetabular roof (HP:0003180)1.87131771
131Radial bowing (HP:0002986)1.87088450
132Abnormality of renin-angiotensin system (HP:0000847)1.86753202
133Abnormality of liposaccharide metabolism (HP:0010968)1.84895280
134Abnormality of glycosphingolipid metabolism (HP:0004343)1.84895280
135Abnormality of glycolipid metabolism (HP:0010969)1.84895280
136Metabolic alkalosis (HP:0200114)1.83769498
137Polygenic inheritance (HP:0010982)1.83759670
138Neoplasm of the heart (HP:0100544)1.83478224
139Cystic liver disease (HP:0006706)1.82856477
140Fibrous tissue neoplasm (HP:0012316)1.82628884
141Hepatocellular necrosis (HP:0001404)1.81735959
142Pendular nystagmus (HP:0012043)1.81188896
143Abnormality of the 1st metacarpal (HP:0010009)1.81132765
144High pitched voice (HP:0001620)1.80779803
145Molar tooth sign on MRI (HP:0002419)1.80612195
146Abnormality of midbrain morphology (HP:0002418)1.80612195
147Hyperlipoproteinemia (HP:0010980)1.79605913
148Abnormality of T cells (HP:0002843)1.79518816
149Deviation of the thumb (HP:0009603)1.79322983
150Recurrent abscess formation (HP:0002722)1.79105751
151Abolished electroretinogram (ERG) (HP:0000550)1.78905960
152Increased connective tissue (HP:0009025)1.78869995
153Recurrent skin infections (HP:0001581)1.78585441
154Thin bony cortex (HP:0002753)1.78460142
155Vasculitis (HP:0002633)1.77321024
156Stomach cancer (HP:0012126)1.77083707
157Cheilitis (HP:0100825)1.76590856
158Testicular atrophy (HP:0000029)1.75720039
159Pulmonary infiltrates (HP:0002113)1.75224329
160Bony spicule pigmentary retinopathy (HP:0007737)1.75088596
161Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75043749
162Hepatic necrosis (HP:0002605)1.74293728
163Abnormal hemoglobin (HP:0011902)1.73973213
164Polyuria (HP:0000103)1.73463331
165Delayed CNS myelination (HP:0002188)1.73182814
166Type II lissencephaly (HP:0007260)1.73120900
167Metaphyseal cupping (HP:0003021)1.72824233
168Hypoalphalipoproteinemia (HP:0003233)1.71865518
169Abnormality of oral frenula (HP:0000190)1.70808787
170Encephalitis (HP:0002383)1.70490433
171Medulloblastoma (HP:0002885)1.69969330
172Global brain atrophy (HP:0002283)1.69095940
173Bowel diverticulosis (HP:0005222)1.68788914
174Back pain (HP:0003418)1.68726375
175Malignant gastrointestinal tract tumors (HP:0006749)1.67824843
176Gastrointestinal carcinoma (HP:0002672)1.67824843
177Bowed forearm bones (HP:0003956)1.67682239
178Bowing of the arm (HP:0006488)1.67682239
179Sandal gap (HP:0001852)1.67079962
180Missing ribs (HP:0000921)1.66625114
181Stroke (HP:0001297)1.65985086
182Deep palmar crease (HP:0006191)1.65865819
183Long toe (HP:0010511)1.64916814
184Proximal placement of thumb (HP:0009623)1.64200577
185Neonatal onset (HP:0003623)1.63407395
186Abnormality of the diencephalon (HP:0010662)1.63207710
187Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.63073937
188Rectal prolapse (HP:0002035)1.62973619
189Skin nodule (HP:0200036)1.62519428
190Hypoplastic toenails (HP:0001800)1.60771401
191Vertebral clefting (HP:0008428)1.60723148
192Abnormality of reticulocytes (HP:0004312)1.60389106
193Bladder diverticulum (HP:0000015)1.59683516
194Complement deficiency (HP:0004431)1.59378063

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.20862073
2CDK123.64328274
3EEF2K3.50956740
4MAP3K103.39862751
5TAOK33.16746723
6TRIB33.11493900
7PKN23.08477374
8MAP4K12.89370105
9TNK22.45469670
10EPHA22.27254483
11MAPKAPK32.23868989
12ERN12.07316546
13TXK2.06432014
14RPS6KB22.01969760
15NEK11.95905496
16RIPK11.95198387
17MAP2K61.94969599
18WNK41.87087423
19PTK61.84739877
20MAP3K91.82241493
21NEK21.77208426
22ADRBK21.75282568
23KSR21.74474416
24GRK61.59794107
25CDC71.54329419
26GRK11.53113515
27SIK21.50138941
28MAP3K81.49270226
29IKBKB1.45274983
30TTN1.44576220
31TBK11.41406778
32LATS11.39163250
33IKBKE1.36091270
34STK101.35846871
35MAP4K21.35064773
36PDGFRA1.33344861
37SIK11.33019748
38IRAK11.32821162
39ICK1.32803394
40TYRO31.31398456
41PAK41.30049016
42SCYL21.28765071
43CAMK1D1.28535440
44IRAK41.27907289
45FGFR41.26468964
46LRRK21.26256473
47LATS21.24103326
48PRKD21.22643521
49IRAK31.21737804
50PINK11.21380874
51ALK1.20805574
52MAP3K71.20680619
53MTOR1.20608543
54FES1.19593727
55EPHB21.19493569
56BUB11.18295653
57BCKDK1.15728064
58WEE11.14592705
59MAPK131.13732218
60BLK1.11181257
61ITK1.10476809
62BMX1.09771983
63TTK1.09596936
64MAP3K31.08675356
65KSR11.08220884
66MAP3K21.06491947
67PTK21.06364828
68TAOK11.04585459
69EPHA31.03635498
70ZAP701.01508371
71MAP3K131.00808529
72PDK20.97371337
73PAK20.96474770
74CHUK0.94654948
75JAK30.93854091
76FLT30.92517626
77CDK70.92291922
78PDK10.91846303
79CDK40.91322941
80TGFBR10.91297779
81BTK0.89939425
82MARK30.88745609
83MAP3K140.88069410
84DDR20.86763677
85PDPK10.86551799
86BMPR1B0.86313351
87MAP2K20.85664544
88CAMKK20.85035586
89FGFR20.84462065
90STK390.84280637
91PHKG10.83839385
92PHKG20.83839385
93INSRR0.83390908
94DYRK1B0.82984272
95SYK0.81557390
96CDC42BPA0.80980080
97HIPK20.79809390
98CDK60.79704414
99CSF1R0.79361054
100NME10.78150077
101MARK20.77693593
102FGFR30.76148444
103NTRK30.73959806
104BRD40.73049264
105AKT20.72268641
106MAPK110.71178632
107HCK0.70922083
108RAF10.70132646
109MAP2K30.69901572
110SIK30.69700198
111LCK0.68038365
112AURKB0.67126176
113TEC0.66820269
114EPHB10.65093005
115OXSR10.64535459
116CSK0.63685361
117MAPK150.63269889
118PRKAA20.63174670
119MAP2K10.60805316
120FER0.60794920
121KIT0.60462582
122LYN0.59591350
123CAMK1G0.59320630
124PRKCZ0.59068352
125MELK0.58891176
126RPS6KA60.58485013
127PDK30.57560224
128PDK40.57560224
129PRKCQ0.57105772
130MUSK0.56972028
131JAK10.56955782
132MAPK120.56353339
133RPS6KA20.56078832
134STK380.56061101
135TLK10.55958556
136PAK60.54093195
137SMG10.52592060
138PRKCI0.52437923
139MAP3K110.51979245
140DAPK10.51553775
141EIF2AK10.50913006
142ERBB20.50680996
143PTK2B0.50664543
144TGFBR20.50598085
145TRPM70.50500494
146PAK10.50411749
147CDK90.50037587
148AURKA0.49872899
149FGFR10.49659408
150NLK0.49444433
151PRKD30.49104730
152CHEK10.48995970
153MOS0.45976112
154PLK10.45949170
155ERBB40.45580434
156STK110.44314320
157CDK20.44261506
158PASK0.44054256
159MET0.42982787
160MST1R0.42817515
161CSNK1E0.41563117
162RPS6KA10.41450174
163RET0.41324146
164STK30.40837842
165BRSK10.40557303
166CAMKK10.39876543
167LMTK20.39320767
168TYK20.39032430
169DAPK20.38947730
170PRKAA10.38315286
171ACVR1B0.37531799

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.34802056
2Nitrogen metabolism_Homo sapiens_hsa009103.30012397
3Other glycan degradation_Homo sapiens_hsa005112.88633359
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.81446190
5Arginine biosynthesis_Homo sapiens_hsa002202.65660656
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.60280444
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.50710572
8Primary immunodeficiency_Homo sapiens_hsa053402.47119472
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.46569900
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.44113440
11Biosynthesis of amino acids_Homo sapiens_hsa012302.34200937
12Linoleic acid metabolism_Homo sapiens_hsa005912.33637681
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30079043
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28686619
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.28476012
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.25539839
17One carbon pool by folate_Homo sapiens_hsa006702.13106594
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10602279
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07714545
20Primary bile acid biosynthesis_Homo sapiens_hsa001202.02334966
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.94044869
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91398128
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79406348
24Carbon metabolism_Homo sapiens_hsa012001.77737181
25Ether lipid metabolism_Homo sapiens_hsa005651.74274414
26Fat digestion and absorption_Homo sapiens_hsa049751.65928571
27Bile secretion_Homo sapiens_hsa049761.62325471
28Lysine degradation_Homo sapiens_hsa003101.61713904
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59972009
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57480492
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56064971
32Selenocompound metabolism_Homo sapiens_hsa004501.54030469
33Allograft rejection_Homo sapiens_hsa053301.53203846
34Autoimmune thyroid disease_Homo sapiens_hsa053201.51154157
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.48934249
36Tryptophan metabolism_Homo sapiens_hsa003801.47722774
37Fatty acid degradation_Homo sapiens_hsa000711.46932035
38Lysosome_Homo sapiens_hsa041421.44542506
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.44495707
40Staphylococcus aureus infection_Homo sapiens_hsa051501.42073008
41Graft-versus-host disease_Homo sapiens_hsa053321.36099191
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33900332
43Bladder cancer_Homo sapiens_hsa052191.33883567
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.29183008
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28143673
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26644845
47Basal cell carcinoma_Homo sapiens_hsa052171.26078147
48mTOR signaling pathway_Homo sapiens_hsa041501.20936734
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.19986827
50Asthma_Homo sapiens_hsa053101.18280394
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.17607463
52Type I diabetes mellitus_Homo sapiens_hsa049401.16978592
53T cell receptor signaling pathway_Homo sapiens_hsa046601.11108117
54Arachidonic acid metabolism_Homo sapiens_hsa005901.10663994
55Pentose phosphate pathway_Homo sapiens_hsa000301.10369913
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09572913
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.09016096
58PPAR signaling pathway_Homo sapiens_hsa033201.08546886
59Sphingolipid metabolism_Homo sapiens_hsa006001.06922481
60Caffeine metabolism_Homo sapiens_hsa002321.05286975
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04987970
62Pyruvate metabolism_Homo sapiens_hsa006201.02900590
63Complement and coagulation cascades_Homo sapiens_hsa046101.00537845
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99415294
65Hedgehog signaling pathway_Homo sapiens_hsa043400.98935114
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98215932
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97204009
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95930300
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93711538
70* Fructose and mannose metabolism_Homo sapiens_hsa000510.93438520
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92720397
72Phenylalanine metabolism_Homo sapiens_hsa003600.91552881
73RNA transport_Homo sapiens_hsa030130.90048466
74Glucagon signaling pathway_Homo sapiens_hsa049220.89785760
75Ovarian steroidogenesis_Homo sapiens_hsa049130.88971949
76Hippo signaling pathway_Homo sapiens_hsa043900.87269640
77Systemic lupus erythematosus_Homo sapiens_hsa053220.86566023
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85890438
79Proteoglycans in cancer_Homo sapiens_hsa052050.83642712
80Sulfur relay system_Homo sapiens_hsa041220.81813782
81Retinol metabolism_Homo sapiens_hsa008300.81548992
82Folate biosynthesis_Homo sapiens_hsa007900.80581878
83Starch and sucrose metabolism_Homo sapiens_hsa005000.80482764
84Glycerolipid metabolism_Homo sapiens_hsa005610.79569340
85Osteoclast differentiation_Homo sapiens_hsa043800.78763853
86Mismatch repair_Homo sapiens_hsa034300.78135670
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77731593
88Propanoate metabolism_Homo sapiens_hsa006400.76085973
89B cell receptor signaling pathway_Homo sapiens_hsa046620.75579686
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73989774
91Adherens junction_Homo sapiens_hsa045200.73987523
92Galactose metabolism_Homo sapiens_hsa000520.73702134
93MicroRNAs in cancer_Homo sapiens_hsa052060.71438904
94Thyroid cancer_Homo sapiens_hsa052160.71033306
95Non-small cell lung cancer_Homo sapiens_hsa052230.70785591
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.70590935
97Insulin resistance_Homo sapiens_hsa049310.68528557
98Butanoate metabolism_Homo sapiens_hsa006500.68404120
99Sulfur metabolism_Homo sapiens_hsa009200.67752713
100Chemical carcinogenesis_Homo sapiens_hsa052040.66674668
101Insulin signaling pathway_Homo sapiens_hsa049100.65004294
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64828441
103Chronic myeloid leukemia_Homo sapiens_hsa052200.64572232
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63502048
105VEGF signaling pathway_Homo sapiens_hsa043700.62793316
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62599410
107Regulation of autophagy_Homo sapiens_hsa041400.62078524
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62025003
109Arginine and proline metabolism_Homo sapiens_hsa003300.61362878
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.61298342
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61129047
112Collecting duct acid secretion_Homo sapiens_hsa049660.60937126
113Dorso-ventral axis formation_Homo sapiens_hsa043200.60641561
114Acute myeloid leukemia_Homo sapiens_hsa052210.60597653
115Fatty acid metabolism_Homo sapiens_hsa012120.59353025
116Inositol phosphate metabolism_Homo sapiens_hsa005620.59047990
117Small cell lung cancer_Homo sapiens_hsa052220.58912421
118DNA replication_Homo sapiens_hsa030300.57588916
119Tuberculosis_Homo sapiens_hsa051520.56719020
120Histidine metabolism_Homo sapiens_hsa003400.56480690
121Phototransduction_Homo sapiens_hsa047440.55755307
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55586703
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55445047
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55272517
125Leishmaniasis_Homo sapiens_hsa051400.54096801
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53585698
127Endometrial cancer_Homo sapiens_hsa052130.53082530
128TNF signaling pathway_Homo sapiens_hsa046680.53075110
129Spliceosome_Homo sapiens_hsa030400.52797951
130Mineral absorption_Homo sapiens_hsa049780.52496524
131AMPK signaling pathway_Homo sapiens_hsa041520.52281703
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51294237
133mRNA surveillance pathway_Homo sapiens_hsa030150.51045137
134HIF-1 signaling pathway_Homo sapiens_hsa040660.50892033
135Protein digestion and absorption_Homo sapiens_hsa049740.49627793
136Estrogen signaling pathway_Homo sapiens_hsa049150.48430875
137Glioma_Homo sapiens_hsa052140.48194387
138p53 signaling pathway_Homo sapiens_hsa041150.47764267
139Hepatitis C_Homo sapiens_hsa051600.46327817
140Melanogenesis_Homo sapiens_hsa049160.45568555
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44934315
142Tyrosine metabolism_Homo sapiens_hsa003500.44242202
143Insulin secretion_Homo sapiens_hsa049110.44116367
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43634744
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43122450
146Peroxisome_Homo sapiens_hsa041460.42787794
147* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42693756
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42423221
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42294840
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42045994
151beta-Alanine metabolism_Homo sapiens_hsa004100.41799077
152Cell cycle_Homo sapiens_hsa041100.41784794
153Notch signaling pathway_Homo sapiens_hsa043300.40525795
154Hematopoietic cell lineage_Homo sapiens_hsa046400.40412010
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.39949001
156ABC transporters_Homo sapiens_hsa020100.39888592
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39318307
158TGF-beta signaling pathway_Homo sapiens_hsa043500.39141683
159Amoebiasis_Homo sapiens_hsa051460.39092649
160Focal adhesion_Homo sapiens_hsa045100.38005837
161Vitamin digestion and absorption_Homo sapiens_hsa049770.37935541
162Rheumatoid arthritis_Homo sapiens_hsa053230.37841579
163Antigen processing and presentation_Homo sapiens_hsa046120.36666177
164Choline metabolism in cancer_Homo sapiens_hsa052310.35987545

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