ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	9.80235244
2	microtubule depolymerization (GO:0007019)	8.45461411
3	sperm capacitation (GO:0048240)	8.09808391
4	single strand break repair (GO:0000012)	8.02839779
5	chromosome condensation (GO:0030261)	7.93501784
6	DNA packaging (GO:0006323)	7.86431667
7	spermatid development (GO:0007286)	7.82084223
8	plasma membrane fusion (GO:0045026)	7.56677364
9	spermatid nucleus differentiation (GO:0007289)	7.26913695
10	rRNA methylation (GO:0031167)	7.03892976
11	response to pheromone (GO:0019236)	6.81475406
12	protein polyglutamylation (GO:0018095)	6.73149845
13	multicellular organism reproduction (GO:0032504)	6.67068394
14	microtubule polymerization or depolymerization (GO:0031109)	6.65363050
15	sperm-egg recognition (GO:0035036)	6.52785770
16	rRNA modification (GO:0000154)	6.38882541
17	reproduction (GO:0000003)	6.31427008
18	axonemal dynein complex assembly (GO:0070286)	6.29311098
19	sexual reproduction (GO:0019953)	6.20705562
20	protein targeting to Golgi (GO:0000042)	5.97247376
21	calcium ion-dependent exocytosis (GO:0017156)	5.73045281
22	regulation of cilium movement (GO:0003352)	5.72699014
23	establishment of protein localization to Golgi (GO:0072600)	5.72219252
24	centriole replication (GO:0007099)	5.64363325
25	cellular ketone body metabolic process (GO:0046950)	5.60173820
26	spermatogenesis (GO:0007283)	5.59672516
27	microtubule severing (GO:0051013)	5.59295407
28	male gamete generation (GO:0048232)	5.58371218
29	RNA destabilization (GO:0050779)	5.58228308
30	binding of sperm to zona pellucida (GO:0007339)	5.56401022
31	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.50928681
32	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.49198789
33	cell-cell recognition (GO:0009988)	5.30346406
34	phosphatidylethanolamine metabolic process (GO:0046337)	5.21662509
35	gamete generation (GO:0007276)	5.14495226
36	negative regulation of inclusion body assembly (GO:0090084)	5.13262436
37	ketone body metabolic process (GO:1902224)	4.93709598
38	epithelial cilium movement (GO:0003351)	4.93447444
39	cilium or flagellum-dependent cell motility (GO:0001539)	4.83712694
40	centriole assembly (GO:0098534)	4.83426754
41	cell wall macromolecule metabolic process (GO:0044036)	4.72651795
42	single fertilization (GO:0007338)	4.63156193
43	motile cilium assembly (GO:0044458)	4.37295810
44	regulation of microtubule-based movement (GO:0060632)	4.34668508
45	protein localization to Golgi apparatus (GO:0034067)	4.32557605
46	regulation of transcription involved in cell fate commitment (GO:0060850)	4.30835065
47	germ cell development (GO:0007281)	4.30731689
48	cilium movement (GO:0003341)	4.25031929
49	cell wall macromolecule catabolic process (GO:0016998)	4.23654997
50	multicellular organismal reproductive process (GO:0048609)	4.08959377
51	regulation of centriole replication (GO:0046599)	4.07673722
52	piRNA metabolic process (GO:0034587)	4.02976338
53	positive regulation of Rab GTPase activity (GO:0032851)	4.01028517
54	regulation of Rab GTPase activity (GO:0032313)	4.01028517
55	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.97125925
56	seminiferous tubule development (GO:0072520)	3.97081177
57	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.88606875
58	fertilization (GO:0009566)	3.86006688
59	polyamine biosynthetic process (GO:0006596)	3.81819708
60	organic cation transport (GO:0015695)	3.76322268
61	regulation of inclusion body assembly (GO:0090083)	3.66143212
62	DNA methylation involved in gamete generation (GO:0043046)	3.56136165
63	musculoskeletal movement (GO:0050881)	3.49147443
64	multicellular organismal movement (GO:0050879)	3.49147443
65	sequestering of actin monomers (GO:0042989)	3.38341530
66	glycerol ether metabolic process (GO:0006662)	3.32387460
67	regulation of interleukin-13 production (GO:0032656)	3.23928828
68	nucleus organization (GO:0006997)	3.23109452
69	histone exchange (GO:0043486)	3.18868498
70	microtubule nucleation (GO:0007020)	3.13422659
71	response to acidic pH (GO:0010447)	3.11355219
72	ether metabolic process (GO:0018904)	3.10083276
73	male meiosis (GO:0007140)	3.08419134
74	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.07579830
75	coenzyme catabolic process (GO:0009109)	3.06312781
76	regulation of somitogenesis (GO:0014807)	3.04552746
77	male meiosis I (GO:0007141)	3.04492456
78	chromatin silencing (GO:0006342)	2.99702619
79	multicellular organismal development (GO:0007275)	2.97627005
80	protein neddylation (GO:0045116)	2.94582493
81	positive regulation of endothelial cell differentiation (GO:0045603)	2.93316964
82	cellular response to pH (GO:0071467)	2.93074009
83	negative regulation of Rho protein signal transduction (GO:0035024)	2.90510794
84	spinal cord motor neuron differentiation (GO:0021522)	2.86658722
85	regulation of meiosis I (GO:0060631)	2.79027866
86	membrane protein intracellular domain proteolysis (GO:0031293)	2.77056137
87	pattern specification involved in kidney development (GO:0061004)	2.75257819
88	cell recognition (GO:0008037)	2.72923084
89	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.72084192
90	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.68925265
91	cerebral cortex neuron differentiation (GO:0021895)	2.68578992
92	cellular biogenic amine biosynthetic process (GO:0042401)	2.67786285
93	axoneme assembly (GO:0035082)	2.67536706
94	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.63116292
95	positive regulation of guanylate cyclase activity (GO:0031284)	2.59434907
96	cranial nerve morphogenesis (GO:0021602)	2.59144623
97	somite rostral/caudal axis specification (GO:0032525)	2.58186554
98	meiosis I (GO:0007127)	2.58118081
99	sperm motility (GO:0030317)	11.2072024
100	acrosome reaction (GO:0007340)	10.3445219

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.71712615
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.19352988
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.84337528
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.49694680
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.49694680
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.39662067
7	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.37332653
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35724691
9	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.24273365
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.19987944
11	VDR_22108803_ChIP-Seq_LS180_Human	2.17819251
12	FUS_26573619_Chip-Seq_HEK293_Human	2.14775572
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.08089769
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.00254008
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.94468968
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.91997491
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91284540
18	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.90469711
19	CBP_20019798_ChIP-Seq_JUKART_Human	1.90469711
20	ERA_21632823_ChIP-Seq_H3396_Human	1.83932736
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.77715462
22	P300_19829295_ChIP-Seq_ESCs_Human	1.72191623
23	TAF2_19829295_ChIP-Seq_ESCs_Human	1.71873596
24	AR_25329375_ChIP-Seq_VCAP_Human	1.65950846
25	NANOG_20526341_ChIP-Seq_ESCs_Human	1.64928065
26	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.63083922
27	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.62406522
28	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.61002131
29	ERG_20517297_ChIP-Seq_VCAP_Human	1.59335032
30	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.59329613
31	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.58206111
32	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.54354202
33	ZNF274_21170338_ChIP-Seq_K562_Hela	1.51860981
34	RAC3_21632823_ChIP-Seq_H3396_Human	1.48650350
35	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.47747953
36	MYC_19829295_ChIP-Seq_ESCs_Human	1.46829360
37	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.46296974
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.43813702
39	GBX2_23144817_ChIP-Seq_PC3_Human	1.43674833
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.43177533
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43118475
42	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.39770635
43	* RBPJ_21746931_ChIP-Seq_IB4_Human	1.39710975
44	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.39003467
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37711768
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37711768
47	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.37499429
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36714555
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36714555
50	OCT4_20526341_ChIP-Seq_ESCs_Human	1.36203559
51	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.36017545
52	* ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.35837703
53	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.35821522
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34554012
55	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.33942231
56	DROSHA_22980978_ChIP-Seq_HELA_Human	1.33600259
57	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31798754
58	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.28144381
59	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.27815902
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26480266
61	* ETV1_20927104_ChIP-Seq_GIST48_Human	1.26305338
62	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.26247122
63	CTCF_27219007_Chip-Seq_Bcells_Human	1.23949452
64	E2F1_20622854_ChIP-Seq_HELA_Human	1.23795174
65	BCL6_27268052_Chip-Seq_Bcells_Human	1.23219355
66	* YY1_22570637_ChIP-Seq_MALME-3M_Human	1.22587690
67	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.22181700
68	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.19778119
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19702550
70	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.19183007
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.19027229
72	CEBPB_22108803_ChIP-Seq_LS180_Human	1.17641066
73	CTCF_20526341_ChIP-Seq_ESCs_Human	1.17224220
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16422783
75	NFYB_21822215_ChIP-Seq_K562_Human	1.15755449
76	P300_27268052_Chip-Seq_Bcells_Human	1.15567445
77	PHF8_20622853_ChIP-Seq_HELA_Human	1.15134692
78	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.14759236
79	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.13265298
80	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.11761447
81	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10743353
82	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10713940
83	P53_21459846_ChIP-Seq_SAOS-2_Human	1.10211112
84	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.09009086
85	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08485065
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07880791
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07064642
88	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.05642154
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05578011
90	STAT3_23295773_ChIP-Seq_U87_Human	1.05291157
91	TBL1_22424771_ChIP-Seq_293T_Human	1.04642555
92	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.04197446
93	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.03318641
94	NFYA_21822215_ChIP-Seq_K562_Human	1.03038634
95	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.03037412
96	* PHF8_20622854_ChIP-Seq_HELA_Human	1.01936929
97	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01629277
98	NCOR_22424771_ChIP-Seq_293T_Human	1.00846975
99	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00531276
100	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99927361

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	4.22131280
2	MP0003878_abnormal_ear_physiology	4.22131280
3	MP0003698_abnormal_male_reproductive	3.94973488
4	MP0005670_abnormal_white_adipose	3.74783456
5	MP0001929_abnormal_gametogenesis	3.50362370
6	MP0002822_catalepsy	2.68556903
7	MP0003718_maternal_effect	2.54654406
8	MP0003011_delayed_dark_adaptation	2.34819154
9	MP0001348_abnormal_lacrimal_gland	2.33048092
10	MP0002161_abnormal_fertility/fecundity	2.21035241
11	MP0005410_abnormal_fertilization	10.3268120
12	MP0009379_abnormal_foot_pigmentation	1.94872397
13	MP0000566_synostosis	1.94231621
14	MP0003646_muscle_fatigue	1.83289033
15	MP0002210_abnormal_sex_determination	1.81718664
16	MP0001968_abnormal_touch/_nociception	1.78984436
17	MP0002234_abnormal_pharynx_morphology	1.73778362
18	MP0001485_abnormal_pinna_reflex	1.65145615
19	MP0002735_abnormal_chemical_nociception	1.60280849
20	MP0002653_abnormal_ependyma_morphology	1.50335182
21	MP0005423_abnormal_somatic_nervous	1.50258921
22	MP0008877_abnormal_DNA_methylation	1.46834001
23	MP0000653_abnormal_sex_gland	1.45603687
24	MP0001145_abnormal_male_reproductive	1.42362883
25	MP0001486_abnormal_startle_reflex	1.40853383
26	MP0002736_abnormal_nociception_after	1.38042732
27	MP0002132_abnormal_respiratory_system	1.36481971
28	MP0005551_abnormal_eye_electrophysiolog	1.35460888
29	MP0002282_abnormal_trachea_morphology	1.32854032
30	MP0009053_abnormal_anal_canal	1.32616248
31	MP0004742_abnormal_vestibular_system	1.30910554
32	MP0005084_abnormal_gallbladder_morpholo	1.27827442
33	MP0000678_abnormal_parathyroid_gland	1.25053186
34	MP0001905_abnormal_dopamine_level	1.22956610
35	MP0009697_abnormal_copulation	1.20124133
36	MP0003283_abnormal_digestive_organ	1.18195601
37	MP0004859_abnormal_synaptic_plasticity	1.15106194
38	MP0005379_endocrine/exocrine_gland_phen	1.13788627
39	MP0001765_abnormal_ion_homeostasis	1.10935210
40	MP0005646_abnormal_pituitary_gland	1.08666906
41	MP0001963_abnormal_hearing_physiology	1.07866291
42	MP0005310_abnormal_salivary_gland	1.06949610
43	MP0002138_abnormal_hepatobiliary_system	1.06715173
44	MP0000026_abnormal_inner_ear	1.06690665
45	MP0005253_abnormal_eye_physiology	1.06582029
46	MP0005645_abnormal_hypothalamus_physiol	1.04979925
47	MP0009745_abnormal_behavioral_response	1.04887063
48	MP0002928_abnormal_bile_duct	1.03663698
49	MP0002249_abnormal_larynx_morphology	0.99974541
50	MP0002272_abnormal_nervous_system	0.99189103
51	MP0004142_abnormal_muscle_tone	0.98989479
52	MP0003880_abnormal_central_pattern	0.98963673
53	MP0006292_abnormal_olfactory_placode	0.98516015
54	MP0002067_abnormal_sensory_capabilities	0.96992586
55	MP0005636_abnormal_mineral_homeostasis	0.92630618
56	MP0003879_abnormal_hair_cell	0.91156895
57	MP0005395_other_phenotype	0.90917527
58	MP0002733_abnormal_thermal_nociception	0.86150893
59	MP0008995_early_reproductive_senescence	0.85543850
60	MP0010386_abnormal_urinary_bladder	0.82950671
61	MP0002229_neurodegeneration	0.82802862
62	MP0006276_abnormal_autonomic_nervous	0.82601717
63	MP0005367_renal/urinary_system_phenotyp	0.79624994
64	MP0000516_abnormal_urinary_system	0.79624994
65	MP0002557_abnormal_social/conspecific_i	0.79442550
66	MP0004085_abnormal_heartbeat	0.78161771
67	MP0000049_abnormal_middle_ear	0.77728130
68	MP0000955_abnormal_spinal_cord	0.77009153
69	MP0002572_abnormal_emotion/affect_behav	0.76788123
70	MP0000534_abnormal_ureter_morphology	0.76036120
71	MP0001529_abnormal_vocalization	0.75958341
72	MP0002102_abnormal_ear_morphology	0.74209425
73	MP0005408_hypopigmentation	0.72318478
74	MP0009764_decreased_sensitivity_to	0.71859697
75	MP0001879_abnormal_lymphatic_vessel	0.69921012
76	MP0008789_abnormal_olfactory_epithelium	0.68317998
77	MP0001501_abnormal_sleep_pattern	0.67889012
78	MP0008569_lethality_at_weaning	0.67384406
79	MP0000230_abnormal_systemic_arterial	0.67213324
80	MP0001970_abnormal_pain_threshold	0.67096933
81	MP0001666_abnormal_nutrient_absorption	0.66565061
82	MP0001984_abnormal_olfaction	0.66557779
83	MP0000631_abnormal_neuroendocrine_gland	0.64050835
84	MP0009046_muscle_twitch	0.63913042
85	MP0001440_abnormal_grooming_behavior	0.63798833
86	MP0002734_abnormal_mechanical_nocicepti	0.63690494
87	MP0004510_myositis	0.62905077
88	MP0001188_hyperpigmentation	0.62308359
89	MP0005167_abnormal_blood-brain_barrier	0.57832354
90	MP0002064_seizures	0.57701199
91	MP0008872_abnormal_physiological_respon	0.56995394
92	MP0003119_abnormal_digestive_system	0.56786974
93	MP0001293_anophthalmia	0.55004283
94	MP0006072_abnormal_retinal_apoptosis	0.53655182
95	MP0000372_irregular_coat_pigmentation	0.53101322
96	MP0008875_abnormal_xenobiotic_pharmacok	0.50825898
97	MP0002938_white_spotting	0.49743673
98	MP0005464_abnormal_platelet_physiology	0.49080393
99	MP0008961_abnormal_basal_metabolism	0.48345534
100	MP0003137_abnormal_impulse_conducting	0.47698886

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	5.91277335
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.68255070
3	Absent/shortened dynein arms (HP:0200106)	5.68255070
4	Abnormal ciliary motility (HP:0012262)	4.62000086
5	Abnormal respiratory motile cilium physiology (HP:0012261)	4.51984419
6	Abnormal respiratory epithelium morphology (HP:0012253)	4.48343286
7	Abnormal respiratory motile cilium morphology (HP:0005938)	4.48343286
8	Chronic hepatic failure (HP:0100626)	4.41686549
9	Attenuation of retinal blood vessels (HP:0007843)	4.16175116
10	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.07255772
11	Bony spicule pigmentary retinopathy (HP:0007737)	3.90371130
12	Renal Fanconi syndrome (HP:0001994)	3.87514718
13	Infertility (HP:0000789)	3.66975248
14	Facial shape deformation (HP:0011334)	3.62504819
15	Potter facies (HP:0002009)	3.62504819
16	Tubulointerstitial nephritis (HP:0001970)	3.52111749
17	Enlarged epiphyses (HP:0010580)	3.41560915
18	Abnormality of macular pigmentation (HP:0008002)	3.37352441
19	Generalized aminoaciduria (HP:0002909)	3.35864907
20	Abnormal rod and cone electroretinograms (HP:0008323)	3.20151356
21	Nasal polyposis (HP:0100582)	3.18321540
22	Male infertility (HP:0003251)	3.14039377
23	Nephronophthisis (HP:0000090)	3.03443594
24	Abnormal spermatogenesis (HP:0008669)	3.03256892
25	Rhinitis (HP:0012384)	2.98687770
26	Hyperkalemia (HP:0002153)	2.97683549
27	Asymmetric septal hypertrophy (HP:0001670)	2.97423580
28	Abnormality of renal resorption (HP:0011038)	2.88118046
29	Impulsivity (HP:0100710)	2.87112614
30	Cone-rod dystrophy (HP:0000548)	2.82721534
31	Optic nerve hypoplasia (HP:0000609)	2.77585306
32	Myokymia (HP:0002411)	2.68856646
33	Azoospermia (HP:0000027)	2.65826197
34	Bell-shaped thorax (HP:0001591)	2.61080537
35	Progressive cerebellar ataxia (HP:0002073)	2.60982406
36	Osteomalacia (HP:0002749)	2.60133692
37	Abnormal urine output (HP:0012590)	2.55946746
38	Renal dysplasia (HP:0000110)	2.54768958
39	Abnormality of urine glucose concentration (HP:0011016)	2.53113260
40	Glycosuria (HP:0003076)	2.53113260
41	Abnormality of the renal medulla (HP:0100957)	2.51637036
42	Pancreatic cysts (HP:0001737)	2.49164542
43	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.48277708
44	Resting tremor (HP:0002322)	2.47794164
45	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.46766148
46	Hypoplastic ischia (HP:0003175)	2.43931915
47	Pendular nystagmus (HP:0012043)	2.36940810
48	Abnormality of the nasal mucosa (HP:0000433)	2.36710409
49	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.35598166
50	Polydipsia (HP:0001959)	2.35271748
51	Abnormal drinking behavior (HP:0030082)	2.35271748
52	Type II lissencephaly (HP:0007260)	2.32917440
53	Unilateral renal agenesis (HP:0000122)	2.27971552
54	Exertional dyspnea (HP:0002875)	2.24460779
55	Amelogenesis imperfecta (HP:0000705)	2.23702207
56	Polyuria (HP:0000103)	2.23401233
57	Progressive sensorineural hearing impairment (HP:0000408)	2.19941526
58	Postural instability (HP:0002172)	2.19423026
59	Portal hypertension (HP:0001409)	2.19151668
60	Abnormality of renal excretion (HP:0011036)	2.18751125
61	Chronic bronchitis (HP:0004469)	2.17948684
62	Pancreatic fibrosis (HP:0100732)	2.17587077
63	Hypophosphatemic rickets (HP:0004912)	2.14691291
64	Tubulointerstitial abnormality (HP:0001969)	2.12363535
65	3-Methylglutaconic aciduria (HP:0003535)	2.12295469
66	Abnormality of lateral ventricle (HP:0030047)	2.08623629
67	Bronchiectasis (HP:0002110)	2.07631502
68	Stage 5 chronic kidney disease (HP:0003774)	2.07253743
69	Decreased central vision (HP:0007663)	2.04594987
70	Recurrent corneal erosions (HP:0000495)	2.02559748
71	Optic disc pallor (HP:0000543)	2.02408207
72	Esophageal atresia (HP:0002032)	2.02397282
73	Acute necrotizing encephalopathy (HP:0006965)	2.02290278
74	Abnormality of potassium homeostasis (HP:0011042)	2.02071879
75	Abnormality of the costochondral junction (HP:0000919)	2.01493957
76	Abnormality of dental color (HP:0011073)	1.99892999
77	Abnormal pupillary function (HP:0007686)	1.98505989
78	Abnormality of the ischium (HP:0003174)	1.98401060
79	Abnormality of the hepatic vasculature (HP:0006707)	1.97541592
80	Menstrual irregularities (HP:0000858)	1.94908175
81	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.92462545
82	Increased hepatocellular lipid droplets (HP:0006565)	1.92238625
83	Hypoplasia of the thymus (HP:0000778)	1.91786558
84	Congenital, generalized hypertrichosis (HP:0004540)	1.89977981
85	Cerebellar dysplasia (HP:0007033)	1.89326589
86	Truncal obesity (HP:0001956)	1.85811939
87	Gastrointestinal atresia (HP:0002589)	1.85099578
88	Tubular atrophy (HP:0000092)	1.83848798
89	Hypoalphalipoproteinemia (HP:0003233)	1.82445857
90	Mitochondrial inheritance (HP:0001427)	1.80867005
91	Lipid accumulation in hepatocytes (HP:0006561)	1.79323511
92	Tetany (HP:0001281)	1.76457570
93	Absent thumb (HP:0009777)	1.74125211
94	Hyperphosphaturia (HP:0003109)	1.73049999
95	Bulbous nose (HP:0000414)	1.72698270
96	Median cleft lip (HP:0000161)	1.70860565
97	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.70814863
98	Abnormal mitochondria in muscle tissue (HP:0008316)	1.70752657
99	Acute encephalopathy (HP:0006846)	1.70424056
100	Upper limb muscle weakness (HP:0003484)	1.68472005

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.47491060
2	TESK1	4.73611887
3	PNCK	3.50824992
4	DDR2	3.23850703
5	PLK2	3.05190416
6	MAP4K2	3.03970214
7	INSRR	2.97102483
8	STK38	2.62884219
9	STK38L	2.56416263
10	MAPK15	2.42280592
11	ZAK	2.24765466
12	FRK	1.87810519
13	CAMK1G	1.84843506
14	TLK1	1.82588830
15	PRKD3	1.44423134
16	FGFR2	1.40834126
17	PIK3CG	1.40295938
18	VRK2	1.30017080
19	BRD4	1.26902475
20	VRK1	1.23739496
21	CDK7	1.18635604
22	ACVR1B	1.15824722
23	WNK1	1.15384865
24	ADRBK2	1.14716089
25	WNK4	1.11396661
26	SIK2	1.08884027
27	PDK1	1.08187344
28	NUAK1	1.05976988
29	PDPK1	1.05725340
30	NEK6	1.04910864
31	TIE1	0.99933527
32	BMPR1B	0.97878802
33	PTK2B	0.93530485
34	STK39	0.91836528
35	PRKG1	0.89329025
36	WNK3	0.89115153
37	TESK2	0.88134430
38	DYRK1B	0.86014844
39	PRKCG	0.83867467
40	DYRK2	0.80217557
41	MAP3K9	0.79818642
42	TXK	0.79544081
43	PINK1	0.78598622
44	GRK1	0.75769569
45	SRPK1	0.73704625
46	NME1	0.70330320
47	AKT3	0.70062559
48	TRIM28	0.68258693
49	GRK7	0.64789128
50	MARK1	0.62453259
51	TYRO3	0.61696163
52	TAOK3	0.59601336
53	TAF1	0.57821263
54	BRSK2	0.57687246
55	MINK1	0.56956859
56	NEK2	0.56550394
57	TNIK	0.56135496
58	MAP3K11	0.54086311
59	TEC	0.52414090
60	UHMK1	0.50731516
61	RIPK4	0.49300808
62	PHKG2	0.48488067
63	PHKG1	0.48488067
64	PRKG2	0.47990455
65	MST1R	0.46258589
66	CAMK1	0.45649281
67	MKNK2	0.45629397
68	MAP3K4	0.43913600
69	RPS6KA1	0.43716632
70	PLK3	0.42561969
71	PAK3	0.41445681
72	SGK223	0.41217489
73	SGK494	0.41217489
74	KSR2	0.40347715
75	MAP2K2	0.39468670
76	MAPK13	0.38935222
77	CCNB1	0.38505878
78	BRAF	0.38168691
79	PRKACA	0.37781096
80	CDK3	0.36815768
81	PRKCZ	0.36763580
82	PRKAA2	0.35715787
83	OXSR1	0.35127592
84	PRKCB	0.34087945
85	NTRK3	0.34036345
86	CDK1	0.33974813
87	MYLK	0.33742126
88	DYRK3	0.33327709
89	PRKCE	0.33065496
90	MUSK	0.33000017
91	SYK	0.32946313
92	STK16	0.32328004
93	ADRBK1	0.32027831
94	SGK1	0.31745688
95	ROCK1	0.31640670
96	PRKACB	0.31289526
97	MAP3K12	0.31120178
98	GRK5	0.29720068
99	GSK3B	0.28917088
100	PKN1	0.27862600

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.30300995
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.05670237
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.21256686
4	Olfactory transduction_Homo sapiens_hsa04740	2.86974248
5	Butanoate metabolism_Homo sapiens_hsa00650	2.63003224
6	Parkinsons disease_Homo sapiens_hsa05012	2.60256633
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.51469654
8	Huntingtons disease_Homo sapiens_hsa05016	2.42569786
9	Phototransduction_Homo sapiens_hsa04744	2.30586621
10	Ribosome_Homo sapiens_hsa03010	2.17803979
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.80218366
12	Alzheimers disease_Homo sapiens_hsa05010	1.72556727
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.58313188
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.48226350
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.47070816
16	Allograft rejection_Homo sapiens_hsa05330	1.46437835
17	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.45910506
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.45864681
19	Taste transduction_Homo sapiens_hsa04742	1.38507346
20	RNA polymerase_Homo sapiens_hsa03020	1.31315275
21	RNA transport_Homo sapiens_hsa03013	1.27698711
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.24218526
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21381091
24	Basal transcription factors_Homo sapiens_hsa03022	1.19329089
25	Nicotine addiction_Homo sapiens_hsa05033	1.17308837
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.16347562
27	Asthma_Homo sapiens_hsa05310	1.13304760
28	Fatty acid degradation_Homo sapiens_hsa00071	1.12876001
29	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.09929898
30	Purine metabolism_Homo sapiens_hsa00230	1.08900774
31	Proteasome_Homo sapiens_hsa03050	1.07734741
32	Morphine addiction_Homo sapiens_hsa05032	1.04971840
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.04134883
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00720906
35	Serotonergic synapse_Homo sapiens_hsa04726	1.00210622
36	Protein export_Homo sapiens_hsa03060	0.98715549
37	Antigen processing and presentation_Homo sapiens_hsa04612	0.98225764
38	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97712494
39	Circadian entrainment_Homo sapiens_hsa04713	0.96065906
40	Linoleic acid metabolism_Homo sapiens_hsa00591	0.95446043
41	Fatty acid metabolism_Homo sapiens_hsa01212	0.90618632
42	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87964910
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.87601660
44	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.85477196
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.82467976
46	Oocyte meiosis_Homo sapiens_hsa04114	0.81816058
47	Fat digestion and absorption_Homo sapiens_hsa04975	0.80991764
48	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.78179206
49	Salivary secretion_Homo sapiens_hsa04970	0.78002327
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.77655655
51	Homologous recombination_Homo sapiens_hsa03440	0.77440940
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.70600999
53	Calcium signaling pathway_Homo sapiens_hsa04020	0.69988210
54	Caffeine metabolism_Homo sapiens_hsa00232	0.69598829
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.68678251
56	Retinol metabolism_Homo sapiens_hsa00830	0.67915038
57	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.67032541
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66424445
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65828621
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65712569
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.65458797
62	GABAergic synapse_Homo sapiens_hsa04727	0.64282446
63	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.60533850
64	Metabolic pathways_Homo sapiens_hsa01100	0.59612007
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59439348
66	Tyrosine metabolism_Homo sapiens_hsa00350	0.57325652
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.55958496
68	Protein digestion and absorption_Homo sapiens_hsa04974	0.54735955
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.54550832
70	Renin-angiotensin system_Homo sapiens_hsa04614	0.51615588
71	Alcoholism_Homo sapiens_hsa05034	0.51505921
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.51256646
73	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.50974886
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49849414
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48785247
76	Peroxisome_Homo sapiens_hsa04146	0.46759524
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.46384144
78	Mismatch repair_Homo sapiens_hsa03430	0.45965355
79	PPAR signaling pathway_Homo sapiens_hsa03320	0.45369319
80	Phenylalanine metabolism_Homo sapiens_hsa00360	0.44717085
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44158549
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.43416734
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42229189
84	ABC transporters_Homo sapiens_hsa02010	0.42169075
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.41833819
86	Type II diabetes mellitus_Homo sapiens_hsa04930	0.40288847
87	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40173800
88	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.39988049
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39706821
90	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.36866945
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.36630403
92	Regulation of autophagy_Homo sapiens_hsa04140	0.36253122
93	Selenocompound metabolism_Homo sapiens_hsa00450	0.33504557
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32604827
95	Nucleotide excision repair_Homo sapiens_hsa03420	0.32562599
96	Renin secretion_Homo sapiens_hsa04924	0.32541479
97	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.29500472
98	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.28979269
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.28642618
100	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.27460767

FUNDC2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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