FUOM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.50404007
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.35105729
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.96133360
4ATP synthesis coupled proton transport (GO:0015986)5.96133360
5respiratory electron transport chain (GO:0022904)5.85729944
6electron transport chain (GO:0022900)5.71885974
7glycosphingolipid catabolic process (GO:0046479)4.16853530
8protein complex biogenesis (GO:0070271)3.87562001
9complement activation, alternative pathway (GO:0006957)3.85472689
10phospholipid efflux (GO:0033700)3.82525921
11glycolipid catabolic process (GO:0019377)3.77868557
12positive regulation of lipoprotein lipase activity (GO:0051006)3.74359134
13positive regulation of triglyceride lipase activity (GO:0061365)3.74359134
14fat-soluble vitamin biosynthetic process (GO:0042362)3.67147188
15L-phenylalanine catabolic process (GO:0006559)3.66799805
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.66799805
17hydrogen ion transmembrane transport (GO:1902600)3.60938357
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.60852816
19L-phenylalanine metabolic process (GO:0006558)3.60852816
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.59607998
21NADH dehydrogenase complex assembly (GO:0010257)3.59607998
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.59607998
23ATP biosynthetic process (GO:0006754)3.55734572
24oligosaccharide catabolic process (GO:0009313)3.50412945
25NADH metabolic process (GO:0006734)3.50209148
26immunoglobulin mediated immune response (GO:0016064)3.49471197
27negative regulation of sterol transport (GO:0032372)3.47349925
28negative regulation of cholesterol transport (GO:0032375)3.47349925
29mitochondrial respiratory chain complex assembly (GO:0033108)3.43800183
30urea metabolic process (GO:0019627)3.43574232
31epoxygenase P450 pathway (GO:0019373)3.41734699
32inner mitochondrial membrane organization (GO:0007007)3.35158854
33cellular ketone body metabolic process (GO:0046950)3.33142322
34purine nucleoside triphosphate biosynthetic process (GO:0009145)3.32510761
35succinate metabolic process (GO:0006105)3.32226469
36regulation of mononuclear cell migration (GO:0071675)3.31132672
37regulation of oxidative phosphorylation (GO:0002082)3.31094658
38purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.30924253
39energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.29206293
40ATP hydrolysis coupled proton transport (GO:0015991)3.29206293
41urea cycle (GO:0000050)3.27368686
42nitrogen cycle metabolic process (GO:0071941)3.27248224
43ceramide catabolic process (GO:0046514)3.27073262
44proton transport (GO:0015992)3.24481006
45hydrogen transport (GO:0006818)3.22623392
46very-low-density lipoprotein particle assembly (GO:0034379)3.17582063
47tricarboxylic acid cycle (GO:0006099)3.15895781
48chaperone-mediated protein transport (GO:0072321)3.13794400
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.11482827
50cholesterol efflux (GO:0033344)3.08447492
51regulation of fibrinolysis (GO:0051917)3.05568657
52fibrinolysis (GO:0042730)3.05225769
53plasma lipoprotein particle assembly (GO:0034377)3.04558600
54plasma lipoprotein particle clearance (GO:0034381)3.04497822
55negative regulation of fibrinolysis (GO:0051918)3.02564670
56omega-hydroxylase P450 pathway (GO:0097267)3.01317669
57regulation of cytokine secretion involved in immune response (GO:0002739)2.99991862
58oxidative phosphorylation (GO:0006119)2.97539204
59protein-lipid complex assembly (GO:0065005)2.95548899
60plasma lipoprotein particle remodeling (GO:0034369)2.95100483
61protein-lipid complex remodeling (GO:0034368)2.95100483
62macromolecular complex remodeling (GO:0034367)2.95100483
63detection of calcium ion (GO:0005513)2.93664697
64ketone body metabolic process (GO:1902224)2.93316258
65negative regulation of interleukin-12 production (GO:0032695)2.92480090
66negative regulation of myeloid cell apoptotic process (GO:0033033)2.91792821
67positive regulation of monocyte chemotaxis (GO:0090026)2.91656631
68positive regulation of fatty acid biosynthetic process (GO:0045723)2.90540731
69pinocytosis (GO:0006907)2.90311077
70sphingolipid catabolic process (GO:0030149)2.88751547
71neutrophil activation involved in immune response (GO:0002283)2.87321858
72presynaptic membrane assembly (GO:0097105)2.86353530
73NIK/NF-kappaB signaling (GO:0038061)2.85607948
74short-chain fatty acid metabolic process (GO:0046459)2.85084269
75membrane lipid catabolic process (GO:0046466)2.81881863
76negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.81593965
77B cell mediated immunity (GO:0019724)2.79933979
78amino sugar catabolic process (GO:0046348)2.79361007
79ribonucleoside triphosphate biosynthetic process (GO:0009201)2.78378397
80aldehyde catabolic process (GO:0046185)2.75683614
81aromatic amino acid family catabolic process (GO:0009074)2.75561610
82regulation of superoxide anion generation (GO:0032928)2.75122317
83establishment of protein localization to mitochondrial membrane (GO:0090151)2.74304886
84coenzyme catabolic process (GO:0009109)2.73949689
85regulation of macrophage chemotaxis (GO:0010758)2.73398177
86angiotensin maturation (GO:0002003)2.73145367
87fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.72397197
88GDP-mannose metabolic process (GO:0019673)2.70421154
89oxaloacetate metabolic process (GO:0006107)2.67749880
90response to thyroid hormone (GO:0097066)2.65315446
91response to peptidoglycan (GO:0032494)2.65268523
92low-density lipoprotein particle remodeling (GO:0034374)2.64902641
93drug catabolic process (GO:0042737)2.64421056
94exogenous drug catabolic process (GO:0042738)2.61945035
95presynaptic membrane organization (GO:0097090)2.60957458
96regulation of mitochondrial translation (GO:0070129)2.59625847
97acute-phase response (GO:0006953)2.59616633
98positive regulation of antigen processing and presentation (GO:0002579)2.57596094
99myeloid dendritic cell differentiation (GO:0043011)2.57325594
100generation of precursor metabolites and energy (GO:0006091)2.56845466
101respiratory chain complex IV assembly (GO:0008535)2.56070907
102response to interferon-beta (GO:0035456)2.55585262
103myeloid dendritic cell activation (GO:0001773)2.55487517
104high-density lipoprotein particle remodeling (GO:0034375)2.55013272
105protein carboxylation (GO:0018214)2.53773167
106peptidyl-glutamic acid carboxylation (GO:0017187)2.53773167
107purine deoxyribonucleotide catabolic process (GO:0009155)2.53061247
108negative regulation of nitric oxide biosynthetic process (GO:0045019)2.52804496
109negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.52221106
110cyclooxygenase pathway (GO:0019371)2.51895547
111eosinophil chemotaxis (GO:0048245)2.51352883
112bile acid biosynthetic process (GO:0006699)2.51210984
113lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51207458
114plasma lipoprotein particle organization (GO:0071827)2.50394494
115dicarboxylic acid catabolic process (GO:0043649)2.50008104
116hydrogen peroxide biosynthetic process (GO:0050665)2.49907312
117aerobic respiration (GO:0009060)2.49335308
118protein-lipid complex subunit organization (GO:0071825)2.48762785
119ubiquinone biosynthetic process (GO:0006744)2.47306617
120quinone biosynthetic process (GO:1901663)2.47306617
121positive regulation of chemokine biosynthetic process (GO:0045080)2.46361339
122regulation of protein activation cascade (GO:2000257)2.45836030
123aspartate family amino acid catabolic process (GO:0009068)2.45008798
124dopamine transport (GO:0015872)2.44209496
125glyoxylate metabolic process (GO:0046487)2.44183532
126regulation of triglyceride catabolic process (GO:0010896)2.44142175
127GTP biosynthetic process (GO:0006183)2.44088135
128nucleoside triphosphate biosynthetic process (GO:0009142)2.44025860
129cytochrome complex assembly (GO:0017004)2.43721125
130synaptic vesicle exocytosis (GO:0016079)2.43512516
131cellular response to thyroid hormone stimulus (GO:0097067)2.42974790
132reactive oxygen species biosynthetic process (GO:1903409)2.42379517
133regulation of chemokine biosynthetic process (GO:0045073)2.40649962
134proteasome assembly (GO:0043248)2.40551481
135negative regulation of blood coagulation (GO:0030195)2.40391390
136negative regulation of hemostasis (GO:1900047)2.40391390
137branched-chain amino acid catabolic process (GO:0009083)2.40358464
138complement activation (GO:0006956)2.40329382
139transferrin transport (GO:0033572)2.39521630
140neuron cell-cell adhesion (GO:0007158)2.39324410
141proline metabolic process (GO:0006560)2.38703331
142regulation of antigen processing and presentation (GO:0002577)2.38498222
143triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.36236410
144antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.35589433
145flavonoid metabolic process (GO:0009812)2.34867579
146vitamin biosynthetic process (GO:0009110)2.33929860
147T-helper 1 type immune response (GO:0042088)2.33064646
148regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.32609808
149negative regulation of coagulation (GO:0050819)2.32608699
150N-acetylneuraminate metabolic process (GO:0006054)2.32168063
151trivalent inorganic cation transport (GO:0072512)2.31989019
152ferric iron transport (GO:0015682)2.31989019
153protein localization to cilium (GO:0061512)2.31933303
154vocalization behavior (GO:0071625)2.31571929
155lipoprotein metabolic process (GO:0042157)2.31358745
156regulation of complement activation (GO:0030449)2.31150647
157aromatic amino acid family metabolic process (GO:0009072)2.30623212
158glycoside metabolic process (GO:0016137)2.30451700
159behavioral response to cocaine (GO:0048148)2.30269028
160fatty acid catabolic process (GO:0009062)2.30009346
161ubiquinone metabolic process (GO:0006743)2.25644231
162axoneme assembly (GO:0035082)2.24155396
163fatty acid beta-oxidation (GO:0006635)2.23867764
164neuronal action potential propagation (GO:0019227)2.23799862
165regulation of catecholamine metabolic process (GO:0042069)2.22939592
166regulation of dopamine metabolic process (GO:0042053)2.22939592
167regulation of cholesterol esterification (GO:0010872)2.22009972
168tyrosine metabolic process (GO:0006570)2.21761418
169regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.20961619
170cofactor catabolic process (GO:0051187)2.20940560
171membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.20791342
172regulation of cellular respiration (GO:0043457)2.19710909
173monocarboxylic acid catabolic process (GO:0072329)2.18834580
174regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.18829614
175negative regulation of synaptic transmission, GABAergic (GO:0032229)2.17283362
176lysine catabolic process (GO:0006554)2.14750888
177lysine metabolic process (GO:0006553)2.14750888
178lipid oxidation (GO:0034440)2.14187285
179glutamate metabolic process (GO:0006536)2.13386093
180gluconeogenesis (GO:0006094)2.12940831
181fatty acid oxidation (GO:0019395)2.12647754
182postsynaptic membrane organization (GO:0001941)2.12597944
183quinone metabolic process (GO:1901661)2.11148299
184cysteine metabolic process (GO:0006534)2.10755037
185calcium-mediated signaling using intracellular calcium source (GO:0035584)2.10273419
186cellular respiration (GO:0045333)2.09824580
187positive regulation of amino acid transport (GO:0051957)2.09536334
188regulation of glutamate secretion (GO:0014048)2.09450467
189striatum development (GO:0021756)2.08458652
190tryptophan catabolic process (GO:0006569)2.08031537
191indolalkylamine catabolic process (GO:0046218)2.08031537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.64377382
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.81753513
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.47496977
4GBX2_23144817_ChIP-Seq_PC3_Human3.45552049
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.02761133
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89814894
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.79391662
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.75646702
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43208465
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28813823
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27066536
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26874780
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.26138254
14VDR_21846776_ChIP-Seq_THP-1_Human2.20739039
15TAF15_26573619_Chip-Seq_HEK293_Human2.19839027
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04266011
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.90378046
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89858715
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88799096
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88145182
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87872109
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87280602
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87221362
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86795987
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86726932
26VDR_22108803_ChIP-Seq_LS180_Human1.86241823
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86137277
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85838103
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.83274059
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82131284
31REST_21632747_ChIP-Seq_MESCs_Mouse1.81847312
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.81570921
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80624867
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80107132
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80026757
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.76923386
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75906197
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74436438
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73358116
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72109746
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71849341
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70680015
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.70652796
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68741992
45LXR_22292898_ChIP-Seq_THP-1_Human1.68177354
46* SPI1_23547873_ChIP-Seq_NB4_Human1.66468070
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66126122
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66065255
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65170060
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65170060
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62996406
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61592926
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60229193
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60138374
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60059607
56VDR_24763502_ChIP-Seq_THP-1_Human1.59894692
57P300_19829295_ChIP-Seq_ESCs_Human1.59095164
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.55408014
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.52590120
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.51668799
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51290789
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.50175215
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47303541
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47263877
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47224889
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46450083
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.46330069
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45764232
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43688295
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43170586
71SMAD4_21799915_ChIP-Seq_A2780_Human1.43144981
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.42788648
73E2F7_22180533_ChIP-Seq_HELA_Human1.42200155
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42054515
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40870810
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40002589
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39465290
78MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38679242
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37664601
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37494450
81GABP_17652178_ChIP-ChIP_JURKAT_Human1.37476580
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35681452
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34935381
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34810029
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33758182
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33754491
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.31816439
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31218064
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31013468
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.26951346
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26698899
92DCP1A_22483619_ChIP-Seq_HELA_Human1.25591457
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24992811
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23592090
95TFEB_21752829_ChIP-Seq_HELA_Human1.23230615
96FUS_26573619_Chip-Seq_HEK293_Human1.23097940
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.22349218
98BCL6_27268052_Chip-Seq_Bcells_Human1.22276819
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21918339
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21677109
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20942405
102TET1_21451524_ChIP-Seq_MESCs_Mouse1.20037801
103NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19464366
104RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18052527
105ER_23166858_ChIP-Seq_MCF-7_Human1.17456168
106HTT_18923047_ChIP-ChIP_STHdh_Human1.17145667
107MYC_22102868_ChIP-Seq_BL_Human1.15987382
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14892865
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.14259126
110BCAT_22108803_ChIP-Seq_LS180_Human1.13651271
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13383385
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13201219
113ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13087622
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12698220
115RNF2_27304074_Chip-Seq_ESCs_Mouse1.12444002
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12408281
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12032915
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11628143
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11597891
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11450118
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11050658
122GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10882282
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10635785
124EST1_17652178_ChIP-ChIP_JURKAT_Human1.10387710
125BCOR_27268052_Chip-Seq_Bcells_Human1.09151874
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08551245
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08123576
128DROSHA_22980978_ChIP-Seq_HELA_Human1.08040171
129KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07639360
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06215480
131RUNX1_22412390_ChIP-Seq_EML_Mouse1.05821555
132NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05608540
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05271148
134PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04763472
135CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04725669
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04493938
137HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04101250
138GABP_19822575_ChIP-Seq_HepG2_Human1.03549914
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03260277
140MAF_26560356_Chip-Seq_TH1_Human1.03247582
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02714107
142CTCF_26484167_Chip-Seq_Bcells_Mouse1.02703179
143CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02698100
144HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02625673
145HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02120100
146SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00901527
147GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00479470
148CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00361034
149ZNF263_19887448_ChIP-Seq_K562_Human0.99881848
150AR_25329375_ChIP-Seq_VCAP_Human0.99849349
151MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99527519
152BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97781957
153CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97536646
154XRN2_22483619_ChIP-Seq_HELA_Human0.97310304
155P53_22387025_ChIP-Seq_ESCs_Mouse0.96952021
156NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96777294
157FLI1_27457419_Chip-Seq_LIVER_Mouse0.96412598
158OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96340001
159NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95736254
160TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95677649
161PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94452400
162STAT3_18555785_Chip-Seq_ESCs_Mouse0.93555430
163SOX2_18555785_Chip-Seq_ESCs_Mouse0.92675368
164RARB_27405468_Chip-Seq_BRAIN_Mouse0.92076122
165ERG_21242973_ChIP-ChIP_JURKAT_Human0.91404973
166NANOG_18555785_Chip-Seq_ESCs_Mouse0.91335518
167RNF2_27304074_Chip-Seq_NSC_Mouse0.90525888
168NFE2_27457419_Chip-Seq_LIVER_Mouse0.89264276
169RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88983387
170CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88056132
171OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87744450
172SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87589974
173MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87244925
174CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87118123
175RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86819033
176EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86381407
177E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85675643
178EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85359610
179E2F1_18555785_Chip-Seq_ESCs_Mouse0.85164235
180TAL1_26923725_Chip-Seq_HPCs_Mouse0.84748724
181CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84654454
182PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83460206
183P300_18555785_Chip-Seq_ESCs_Mouse0.83447527
184TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83133717
185EZH2_27294783_Chip-Seq_NPCs_Mouse0.82958539
186RUNX2_22187159_ChIP-Seq_PCA_Human0.82891452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell4.13039507
2MP0005058_abnormal_lysosome_morphology3.99893546
3MP0002837_dystrophic_cardiac_calcinosis3.25526605
4MP0002139_abnormal_hepatobiliary_system3.05339249
5MP0005360_urolithiasis2.79160947
6MP0005085_abnormal_gallbladder_physiolo2.72181954
7MP0006082_CNS_inflammation2.66444192
8MP0002148_abnormal_hypersensitivity_rea2.60241233
9MP0003880_abnormal_central_pattern2.58545828
10MP0003191_abnormal_cellular_cholesterol2.52351948
11MP0005451_abnormal_body_composition2.47327050
12MP0005365_abnormal_bile_salt2.44900754
13MP0003303_peritoneal_inflammation2.42674280
14MP0001835_abnormal_antigen_presentation2.36120309
15MP0002822_catalepsy2.32919683
16MP0004043_abnormal_pH_regulation2.29113880
17MP0008875_abnormal_xenobiotic_pharmacok2.28813357
18MP0009785_altered_susceptibility_to2.28540464
19MP0003195_calcinosis2.17530582
20MP0005646_abnormal_pituitary_gland2.16104748
21MP0006276_abnormal_autonomic_nervous2.15266359
22MP0010386_abnormal_urinary_bladder2.15242895
23MP0003436_decreased_susceptibility_to2.15219857
24MP0002254_reproductive_system_inflammat2.11641323
25MP0002876_abnormal_thyroid_physiology2.10051800
26MP0005671_abnormal_response_to2.08279355
27MP0002638_abnormal_pupillary_reflex2.06679691
28MP0001529_abnormal_vocalization2.01223217
29MP0002419_abnormal_innate_immunity2.00343957
30MP0003172_abnormal_lysosome_physiology1.98617714
31MP0005025_abnormal_response_to1.96580999
32MP0009745_abnormal_behavioral_response1.91132783
33MP0002138_abnormal_hepatobiliary_system1.89072607
34MP0003186_abnormal_redox_activity1.85133632
35MP0001853_heart_inflammation1.82256125
36MP0009764_decreased_sensitivity_to1.82197759
37MP0000604_amyloidosis1.82167819
38MP0002064_seizures1.79057880
39MP0006036_abnormal_mitochondrial_physio1.78369612
40MP0005332_abnormal_amino_acid1.77404272
41MP0001984_abnormal_olfaction1.77137493
42MP0005000_abnormal_immune_tolerance1.75756997
43MP0002736_abnormal_nociception_after1.74434737
44MP0005387_immune_system_phenotype1.72251067
45MP0001790_abnormal_immune_system1.72251067
46MP0005464_abnormal_platelet_physiology1.71538369
47MP0005379_endocrine/exocrine_gland_phen1.71331349
48MP0003635_abnormal_synaptic_transmissio1.70551258
49MP0001968_abnormal_touch/_nociception1.69597734
50MP0008469_abnormal_protein_level1.67549970
51MP0003075_altered_response_to1.66235753
52MP0000685_abnormal_immune_system1.66180451
53MP0009333_abnormal_splenocyte_physiolog1.65989034
54MP0001501_abnormal_sleep_pattern1.65757783
55MP0000343_altered_response_to1.63841417
56MP0009046_muscle_twitch1.62294555
57MP0001440_abnormal_grooming_behavior1.61652814
58MP0002572_abnormal_emotion/affect_behav1.59751927
59MP0004215_abnormal_myocardial_fiber1.59458559
60MP0002272_abnormal_nervous_system1.58017660
61MP0004142_abnormal_muscle_tone1.56425327
62MP0005551_abnormal_eye_electrophysiolog1.53171254
63MP0005645_abnormal_hypothalamus_physiol1.52864880
64MP0002452_abnormal_antigen_presenting1.50658217
65MP0001845_abnormal_inflammatory_respons1.50145669
66MP0003646_muscle_fatigue1.49231126
67MP0002723_abnormal_immune_serum1.48460644
68MP0002734_abnormal_mechanical_nocicepti1.47224730
69MP0002063_abnormal_learning/memory/cond1.46995779
70MP0005535_abnormal_body_temperature1.46967358
71MP0001905_abnormal_dopamine_level1.46055600
72MP0004510_myositis1.40623812
73MP0010155_abnormal_intestine_physiology1.39952186
74MP0004270_analgesia1.39862016
75MP0001486_abnormal_startle_reflex1.39755013
76MP0000751_myopathy1.39493577
77MP0004019_abnormal_vitamin_homeostasis1.37572668
78MP0001800_abnormal_humoral_immune1.36767656
79MP0003806_abnormal_nucleotide_metabolis1.36063584
80MP0003724_increased_susceptibility_to1.35796161
81MP0001545_abnormal_hematopoietic_system1.35368435
82MP0005397_hematopoietic_system_phenotyp1.35368435
83MP0000858_altered_metastatic_potential1.35049945
84MP0004859_abnormal_synaptic_plasticity1.33836530
85MP0003011_delayed_dark_adaptation1.33745028
86MP0001666_abnormal_nutrient_absorption1.31261043
87MP0009379_abnormal_foot_pigmentation1.29890588
88MP0002067_abnormal_sensory_capabilities1.29565645
89MP0002420_abnormal_adaptive_immunity1.28406434
90MP0001819_abnormal_immune_cell1.28157449
91MP0008004_abnormal_stomach_pH1.27050358
92MP0005319_abnormal_enzyme/_coenzyme1.25767045
93MP0003137_abnormal_impulse_conducting1.25625417
94MP0010329_abnormal_lipoprotein_level1.24951550
95MP0001502_abnormal_circadian_rhythm1.24728902
96MP0002735_abnormal_chemical_nociception1.24586400
97MP0002909_abnormal_adrenal_gland1.24556877
98MP0005386_behavior/neurological_phenoty1.24207673
99MP0004924_abnormal_behavior1.24207673
100MP0006054_spinal_hemorrhage1.24093450
101MP0005166_decreased_susceptibility_to1.20979577
102MP0000609_abnormal_liver_physiology1.19566805
103MP0006035_abnormal_mitochondrial_morpho1.19454665
104MP0000013_abnormal_adipose_tissue1.18547119
105MP0001533_abnormal_skeleton_physiology1.17880640
106MP0001188_hyperpigmentation1.16578701
107MP0003252_abnormal_bile_duct1.15792264
108MP0001970_abnormal_pain_threshold1.14803042
109MP0003448_altered_tumor_morphology1.14307970
110MP0004036_abnormal_muscle_relaxation1.13965838
111MP0002557_abnormal_social/conspecific_i1.13428321
112MP0005636_abnormal_mineral_homeostasis1.13186414
113MP0005084_abnormal_gallbladder_morpholo1.12715996
114MP0005083_abnormal_biliary_tract1.11341183
115MP0009763_increased_sensitivity_to1.10964974
116MP0009278_abnormal_bone_marrow1.10934336
117MP0006072_abnormal_retinal_apoptosis1.10023074
118MP0008260_abnormal_autophagy1.08336458
119MP0008872_abnormal_physiological_respon1.08110460
120MP0003879_abnormal_hair_cell1.07137794
121MP0002163_abnormal_gland_morphology1.05626403
122MP0001764_abnormal_homeostasis1.04658694
123MP0002733_abnormal_thermal_nociception1.04538350
124MP0002405_respiratory_system_inflammati1.03608785
125MP0002078_abnormal_glucose_homeostasis1.02391908
126MP0004085_abnormal_heartbeat1.02362889
127MP0000230_abnormal_systemic_arterial1.01566122
128MP0001664_abnormal_digestion1.01297597
129MP0002998_abnormal_bone_remodeling1.00999940
130MP0000490_abnormal_crypts_of1.00760470
131MP0003122_maternal_imprinting0.98719936
132MP0001765_abnormal_ion_homeostasis0.98177133
133MP0001485_abnormal_pinna_reflex0.97822231
134MP0002118_abnormal_lipid_homeostasis0.97008835
135MP0000716_abnormal_immune_system0.96115959
136MP0002132_abnormal_respiratory_system0.94643798
137MP0005310_abnormal_salivary_gland0.93157248
138MP0009697_abnormal_copulation0.92206029
139MP0000749_muscle_degeneration0.92085873
140MP0000538_abnormal_urinary_bladder0.89420764
141MP0002090_abnormal_vision0.88760446
142MP0002229_neurodegeneration0.86728809
143MP0000689_abnormal_spleen_morphology0.86670237
144MP0001986_abnormal_taste_sensitivity0.86409534
145MP0002693_abnormal_pancreas_physiology0.85457622
146MP0002429_abnormal_blood_cell0.85380188
147MP0003329_amyloid_beta_deposits0.84732771
148MP0009643_abnormal_urine_homeostasis0.84669316
149MP0005165_increased_susceptibility_to0.84405214
150MP0005584_abnormal_enzyme/coenzyme_acti0.83963016
151MP0005330_cardiomyopathy0.83860353
152MP0005167_abnormal_blood-brain_barrier0.82411700
153MP0005253_abnormal_eye_physiology0.82165680
154MP0005408_hypopigmentation0.81823474
155MP0005620_abnormal_muscle_contractility0.81800292
156MP0003300_gastrointestinal_ulcer0.81349401
157MP0004947_skin_inflammation0.80587449
158MP0004145_abnormal_muscle_electrophysio0.80284227
159MP0002398_abnormal_bone_marrow0.80248869
160MP0009780_abnormal_chondrocyte_physiolo0.79907921
161MP0002972_abnormal_cardiac_muscle0.79745004
162MP0003953_abnormal_hormone_level0.79212762
163MP0003183_abnormal_peptide_metabolism0.78661164
164MP0003868_abnormal_feces_composition0.78413831
165MP0009765_abnormal_xenobiotic_induced0.78253370
166MP0004883_abnormal_blood_vessel0.74914990
167MP0002722_abnormal_immune_system0.74643311
168MP0000598_abnormal_liver_morphology0.69363061
169MP0001663_abnormal_digestive_system0.67441074
170MP0003453_abnormal_keratinocyte_physiol0.67178836
171MP0005164_abnormal_response_to0.66991785
172MP0010307_abnormal_tumor_latency0.65606452
173MP0001873_stomach_inflammation0.64999554
174MP0003690_abnormal_glial_cell0.63680040
175MP0003656_abnormal_erythrocyte_physiolo0.61994279
176MP0005376_homeostasis/metabolism_phenot0.60496203
177MP0001727_abnormal_embryo_implantation0.59485418

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.35716215
2Acute necrotizing encephalopathy (HP:0006965)5.78531258
3Abnormality of glycolipid metabolism (HP:0010969)5.77445587
4Abnormality of liposaccharide metabolism (HP:0010968)5.77445587
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.77445587
6Abnormal mitochondria in muscle tissue (HP:0008316)5.48786953
7Acute encephalopathy (HP:0006846)5.33037162
8Mitochondrial inheritance (HP:0001427)5.10773692
9Progressive macrocephaly (HP:0004481)4.99301111
10Complement deficiency (HP:0004431)4.71509633
11Hepatocellular necrosis (HP:0001404)4.46296068
12Hepatic necrosis (HP:0002605)4.42539164
13Increased CSF lactate (HP:0002490)4.38210137
14Cerebral edema (HP:0002181)4.25538483
15Vacuolated lymphocytes (HP:0001922)3.94818083
16Abnormality of complement system (HP:0005339)3.91475308
17Increased cerebral lipofuscin (HP:0011813)3.85575516
18Glomerulonephritis (HP:0000099)3.77396752
19Abnormality of macrophages (HP:0004311)3.59363860
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.48989253
21Hypobetalipoproteinemia (HP:0003563)3.47327356
22Recurrent gram-negative bacterial infections (HP:0005420)3.46732735
23Dysostosis multiplex (HP:0000943)3.45654245
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.40181605
25Increased hepatocellular lipid droplets (HP:0006565)3.39415116
26Lipid accumulation in hepatocytes (HP:0006561)3.35763031
27Deep venous thrombosis (HP:0002625)3.33686067
28Increased intramyocellular lipid droplets (HP:0012240)3.32751711
29Optic disc pallor (HP:0000543)3.30972301
30Renal Fanconi syndrome (HP:0001994)3.25402430
31Lactic acidosis (HP:0003128)3.23999990
32Increased muscle lipid content (HP:0009058)3.10796090
33Purpura (HP:0000979)3.10565130
34Respiratory failure (HP:0002878)3.08630221
35Exercise intolerance (HP:0003546)3.06677690
36Upper motor neuron abnormality (HP:0002127)3.05953443
37Loss of speech (HP:0002371)3.00756393
38Recurrent abscess formation (HP:0002722)3.00158586
39Focal motor seizures (HP:0011153)2.92560970
40Ketoacidosis (HP:0001993)2.91874812
41Recurrent bacterial skin infections (HP:0005406)2.88011699
42Abnormality of pyrimidine metabolism (HP:0004353)2.86560635
43Axonal loss (HP:0003447)2.86396693
44Glycosuria (HP:0003076)2.86268917
45Abnormality of urine glucose concentration (HP:0011016)2.86268917
46Pheochromocytoma (HP:0002666)2.86215862
47Increased serum pyruvate (HP:0003542)2.86020820
48Abnormality of glycolysis (HP:0004366)2.86020820
49Disinhibition (HP:0000734)2.84189899
50Lethargy (HP:0001254)2.81656142
51Neuroendocrine neoplasm (HP:0100634)2.78716583
52Obstructive lung disease (HP:0006536)2.77090287
53Chronic obstructive pulmonary disease (HP:0006510)2.77090287
54Abnormality of renal resorption (HP:0011038)2.76998925
55Nausea (HP:0002018)2.71964609
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70613080
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70613080
58Hypoglycemic coma (HP:0001325)2.70535460
59Ketosis (HP:0001946)2.69661292
60Eczematoid dermatitis (HP:0000976)2.69246017
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68833790
62Abnormality of polysaccharide metabolism (HP:0011012)2.68833790
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68833790
64Myocardial infarction (HP:0001658)2.66837711
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66092248
66Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65640771
67Increased serum lactate (HP:0002151)2.64390184
68Petechiae (HP:0000967)2.63302859
69Increased serum ferritin (HP:0003281)2.63264333
70Leukodystrophy (HP:0002415)2.56560526
71Mucopolysacchariduria (HP:0008155)2.53629482
72Urinary glycosaminoglycan excretion (HP:0003541)2.53629482
73Conjugated hyperbilirubinemia (HP:0002908)2.48138055
74Hyperphosphaturia (HP:0003109)2.48085130
75Hyperventilation (HP:0002883)2.47194163
76Hepatosplenomegaly (HP:0001433)2.46749889
77Hypolipoproteinemia (HP:0010981)2.39622269
78Prolonged neonatal jaundice (HP:0006579)2.38324058
79Mediastinal lymphadenopathy (HP:0100721)2.38027261
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35719642
81Dicarboxylic aciduria (HP:0003215)2.35719642
82Generalized aminoaciduria (HP:0002909)2.35055576
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34062924
84CNS demyelination (HP:0007305)2.33777393
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.33391841
86Metabolic acidosis (HP:0001942)2.31421756
87Amyloidosis (HP:0011034)2.31345189
88Joint hemorrhage (HP:0005261)2.29824981
89Hyperglycinemia (HP:0002154)2.27008793
90Medial flaring of the eyebrow (HP:0010747)2.25157395
91Methylmalonic aciduria (HP:0012120)2.25066273
92Multiple enchondromatosis (HP:0005701)2.24453107
93Hyperglycinuria (HP:0003108)2.22809819
94Prolonged partial thromboplastin time (HP:0003645)2.22166469
95Palpitations (HP:0001962)2.21876350
963-Methylglutaconic aciduria (HP:0003535)2.21647234
97Hypothermia (HP:0002045)2.21547883
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21255417
99Ventricular fibrillation (HP:0001663)2.20064146
100Neoplasm of head and neck (HP:0012288)2.19967171
101Esophageal neoplasm (HP:0100751)2.19967171
102Vomiting (HP:0002013)2.19782506
103Methylmalonic acidemia (HP:0002912)2.17066167
104Abnormal ciliary motility (HP:0012262)2.16302479
105Syncope (HP:0001279)2.15551462
106Mutism (HP:0002300)2.14348715
107Gait imbalance (HP:0002141)2.13768985
108Abnormality of iron homeostasis (HP:0011031)2.13255299
109Malnutrition (HP:0004395)2.13099507
110Nephritis (HP:0000123)2.12430825
111Epileptic encephalopathy (HP:0200134)2.11600018
112Abnormal pupillary function (HP:0007686)2.10790496
113Abnormality of fatty-acid metabolism (HP:0004359)2.09644371
114Congenital primary aphakia (HP:0007707)2.09581028
115Abnormal urine phosphate concentration (HP:0012599)2.08953646
116Myokymia (HP:0002411)2.08699417
117Intrahepatic cholestasis (HP:0001406)2.08250004
118Agnosia (HP:0010524)2.07550199
119Progressive neurologic deterioration (HP:0002344)2.07247485
120Autoimmune thrombocytopenia (HP:0001973)2.07040698
121X-linked dominant inheritance (HP:0001423)2.05839562
122Hyperammonemia (HP:0001987)2.05548536
123Congenital sensorineural hearing impairment (HP:0008527)2.05268224
124Ragged-red muscle fibers (HP:0003200)2.03159120
125Abnormal respiratory motile cilium physiology (HP:0012261)2.02467005
126Nephrogenic diabetes insipidus (HP:0009806)2.01271920
127Abnormality of glycine metabolism (HP:0010895)2.01063119
128Abnormality of serine family amino acid metabolism (HP:0010894)2.01063119
129Prolonged QT interval (HP:0001657)2.00894326
130Hypoglycemic seizures (HP:0002173)2.00861627
131Hyperinsulinemic hypoglycemia (HP:0000825)1.99534213
132Sudden death (HP:0001699)1.98715279
133Vertebral compression fractures (HP:0002953)1.97348024
134Emotional lability (HP:0000712)1.94864171
135Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.92693824
136Hypoalphalipoproteinemia (HP:0003233)1.91503807
137Symptomatic seizures (HP:0011145)1.91175049
138Pathologic fracture (HP:0002756)1.91157600
139Exertional dyspnea (HP:0002875)1.90367530
140Renal cortical cysts (HP:0000803)1.89349324
141Poor head control (HP:0002421)1.89320490
142Atonic seizures (HP:0010819)1.88556064
143Gout (HP:0001997)1.88381305
144Absence seizures (HP:0002121)1.88251445
145Reduced antithrombin III activity (HP:0001976)1.87078491
146Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84226874
147Dialeptic seizures (HP:0011146)1.83732064
148Thoracic kyphosis (HP:0002942)1.83669091
149Recurrent skin infections (HP:0001581)1.83545637
150Hydroxyprolinuria (HP:0003080)1.83420845
151Abnormality of proline metabolism (HP:0010907)1.83420845
152Myoglobinuria (HP:0002913)1.82524623
153Renal tubular dysfunction (HP:0000124)1.82237735
154Retinal atrophy (HP:0001105)1.81398074
155Exercise-induced myalgia (HP:0003738)1.81321046
156Generalized tonic-clonic seizures (HP:0002069)1.80941483
157Abnormal trabecular bone morphology (HP:0100671)1.80825311
158Abnormal gallbladder physiology (HP:0012438)1.80662340
159Cholecystitis (HP:0001082)1.80662340
160Personality changes (HP:0000751)1.80368935
161Meningitis (HP:0001287)1.79519824
162Rough bone trabeculation (HP:0100670)1.79215840
163Febrile seizures (HP:0002373)1.78803926
164Decreased circulating renin level (HP:0003351)1.75409090
165Conjunctival telangiectasia (HP:0000524)1.74302294
166Metaphyseal irregularity (HP:0003025)1.74226753
167Peripheral demyelination (HP:0011096)1.73638939
168Hyperlipoproteinemia (HP:0010980)1.72706611
169Increased IgM level (HP:0003496)1.72099669
170Nuclear cataract (HP:0100018)1.72060857
171Abnormality of transition element cation homeostasis (HP:0011030)1.71897457
172Myositis (HP:0100614)1.71688113
173Left ventricular hypertrophy (HP:0001712)1.71428535
174Muscle hypertrophy of the lower extremities (HP:0008968)1.71086339
175Abnormality of monocarboxylic acid metabolism (HP:0010996)1.70805613
176Xanthomatosis (HP:0000991)1.70250248
177Hypertensive crisis (HP:0100735)1.69258687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.93182772
2CASK3.83775805
3BCKDK3.16178849
4PIM23.10560779
5NME12.96954718
6LMTK22.95146230
7INSRR2.79443800
8ERN12.75325264
9NTRK32.72416234
10TESK22.54936652
11VRK22.50692112
12EPHA42.47312509
13MAP3K122.36171178
14MAP3K112.35785795
15WNK42.20350138
16MAP2K72.18316561
17MYLK2.15391811
18MAPK152.14521359
19TAOK22.12405837
20GRK72.05099260
21TYK22.03016799
22MAP4K12.01406111
23MAP2K31.83723828
24KDR1.78747695
25ACVR1B1.76463496
26TGFBR21.74322236
27TBK11.73373969
28MAP3K41.71050453
29PHKG11.67099785
30PHKG21.67099785
31OXSR11.66041228
32MAP3K31.63224054
33GRK51.61248057
34BLK1.59704066
35OBSCN1.57870215
36MAP3K141.52588223
37STK161.44036211
38MATK1.42461646
39STK391.41505468
40FRK1.40525341
41MAP2K41.40193242
42PINK11.37931663
43NEK11.37375681
44AKT31.37357567
45BUB11.37284851
46BMPR21.36068141
47WNK31.35953047
48MUSK1.34646788
49IRAK31.33857966
50DAPK21.30190222
51JAK31.29743501
52IKBKB1.28435519
53CAMK2D1.27232700
54TNIK1.27189289
55CAMK2B1.27147326
56CAMK2A1.25508267
57PAK41.22179506
58ADRBK21.21645423
59ARAF1.20138708
60MST41.16093574
61PRKCG1.15811210
62TESK11.15610675
63PNCK1.12836537
64BCR1.12586630
65MAP3K11.12489896
66PRKCE1.12007985
67STK38L1.11254045
68CAMK2G1.10837913
69FGR1.08609681
70SMG11.07397860
71EIF2AK11.06430901
72DDR21.05312925
73CSF1R1.04982830
74CSK1.04781575
75MINK10.96372430
76IRAK40.95839168
77PDK20.95396030
78PLK20.94620529
79BMPR1B0.91096793
80PRPF4B0.91048003
81MST1R0.90263193
82ADRBK10.89713785
83ZAP700.89163131
84MAPK130.89131962
85GRK10.88448817
86PDK40.87114193
87PDK30.87114193
88PAK30.86781229
89EIF2AK30.86760835
90LYN0.85778433
91PRKACA0.84565492
92IRAK20.84333155
93IKBKE0.83538264
94SYK0.83182039
95TAOK10.82876531
96KIT0.82546936
97PIK3CG0.81601491
98MAP3K80.81383990
99STK100.80609320
100PIK3CA0.80346511
101NTRK10.79605928
102FES0.78136343
103ERBB40.77628557
104SGK4940.76690253
105SGK2230.76690253
106TLK10.76419501
107BTK0.75498107
108PBK0.72623745
109PAK10.72028160
110BRAF0.71404683
111MOS0.71108150
112VRK10.70779954
113DAPK30.70298689
114PIM10.70258849
115TXK0.69867455
116SCYL20.69244447
117PRKG20.65884790
118MARK10.63501809
119MAP3K20.63284903
120DAPK10.62957333
121PKN10.62297656
122MAPK120.62233604
123CDK190.61987475
124CAMKK20.61745462
125CDK50.61369861
126NTRK20.60476980
127IRAK10.60376867
128ZAK0.59839442
129PRKCA0.59576551
130LRRK20.58801088
131ILK0.57999471
132RIPK40.57705318
133ABL20.56965138
134LIMK10.56557616
135NEK60.54755124
136UHMK10.54575346
137PRKACG0.54399151
138SIK30.53431757
139LCK0.53355798
140MAP3K50.52790956
141TIE10.52584530
142DYRK1A0.52166441
143PRKG10.51971211
144ITK0.50868979
145CDK40.50375468
146CDC70.49020160
147MAP2K10.47851365
148MAPK110.46431054
149TEC0.44427518
150MAPK70.44256959
151MAP2K60.43339576
152CDC42BPA0.43128703
153CSNK2A10.43079218
154CDK80.41416672
155HCK0.40467604
156NEK90.40182516
157CSNK1G30.39749953
158PDPK10.39667022
159PRKCQ0.38520995
160MARK30.38037965
161CDK60.36781694
162CLK10.36256564
163PRKAA20.35553105
164MAP2K20.35377721
165PRKCZ0.34604238
166CSNK1A10.34307862
167SGK20.34180016
168PRKCD0.33576024
169RPS6KC10.33195230
170RPS6KL10.33195230
171SRPK10.31144019
172CCNB10.30406410
173STK40.30168674
174RPS6KA50.29132427

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.71809965
2Parkinsons disease_Homo sapiens_hsa050123.76079752
3Alzheimers disease_Homo sapiens_hsa050102.99788135
4Staphylococcus aureus infection_Homo sapiens_hsa051502.75883371
5Other glycan degradation_Homo sapiens_hsa005112.75071548
6Huntingtons disease_Homo sapiens_hsa050162.53457796
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.43700282
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.42227246
9Cardiac muscle contraction_Homo sapiens_hsa042602.22096220
10Collecting duct acid secretion_Homo sapiens_hsa049662.18407104
11Asthma_Homo sapiens_hsa053102.15404782
12Propanoate metabolism_Homo sapiens_hsa006402.04879609
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.96537174
14Allograft rejection_Homo sapiens_hsa053301.93644080
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92558274
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89798434
17Lysosome_Homo sapiens_hsa041421.89756179
18Butanoate metabolism_Homo sapiens_hsa006501.88989222
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84009685
20Caffeine metabolism_Homo sapiens_hsa002321.83175892
21Sulfur metabolism_Homo sapiens_hsa009201.81813275
22Protein export_Homo sapiens_hsa030601.80098708
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.76783377
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75676396
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69771426
26Pyruvate metabolism_Homo sapiens_hsa006201.67170125
27Graft-versus-host disease_Homo sapiens_hsa053321.62861255
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61415779
29Autoimmune thyroid disease_Homo sapiens_hsa053201.61133331
30Nicotine addiction_Homo sapiens_hsa050331.59214776
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57604449
32Fatty acid elongation_Homo sapiens_hsa000621.57593628
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.51233637
34Vibrio cholerae infection_Homo sapiens_hsa051101.50479566
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.49040657
36Synaptic vesicle cycle_Homo sapiens_hsa047211.48614334
37Fatty acid degradation_Homo sapiens_hsa000711.48073564
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39861361
39Antigen processing and presentation_Homo sapiens_hsa046121.39693129
40Tryptophan metabolism_Homo sapiens_hsa003801.37310719
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.30764551
42Leishmaniasis_Homo sapiens_hsa051401.29983735
43Phenylalanine metabolism_Homo sapiens_hsa003601.28311762
44Peroxisome_Homo sapiens_hsa041461.26512194
45Pertussis_Homo sapiens_hsa051331.19949039
46Arginine biosynthesis_Homo sapiens_hsa002201.19679568
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19484522
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19077874
49Fatty acid metabolism_Homo sapiens_hsa012121.16909221
50Tyrosine metabolism_Homo sapiens_hsa003501.16597338
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15974195
52Histidine metabolism_Homo sapiens_hsa003401.14703588
53GABAergic synapse_Homo sapiens_hsa047271.14457380
54Type I diabetes mellitus_Homo sapiens_hsa049401.14328202
55Ribosome_Homo sapiens_hsa030101.13720387
56Carbon metabolism_Homo sapiens_hsa012001.09714581
57Prion diseases_Homo sapiens_hsa050201.08340732
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07036308
59Insulin secretion_Homo sapiens_hsa049111.06330747
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04831837
61Taste transduction_Homo sapiens_hsa047421.01243306
62Systemic lupus erythematosus_Homo sapiens_hsa053221.00408234
63Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00272953
64beta-Alanine metabolism_Homo sapiens_hsa004100.99154625
65DNA replication_Homo sapiens_hsa030300.96755646
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94261123
67PPAR signaling pathway_Homo sapiens_hsa033200.93092416
68Osteoclast differentiation_Homo sapiens_hsa043800.92417970
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90600479
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89880861
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89171445
72Chemical carcinogenesis_Homo sapiens_hsa052040.88894441
73Starch and sucrose metabolism_Homo sapiens_hsa005000.87439566
74Tuberculosis_Homo sapiens_hsa051520.86793170
75Morphine addiction_Homo sapiens_hsa050320.86304559
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86295964
77Folate biosynthesis_Homo sapiens_hsa007900.86052271
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.85655116
79Metabolic pathways_Homo sapiens_hsa011000.84960892
80Arginine and proline metabolism_Homo sapiens_hsa003300.83871274
81Olfactory transduction_Homo sapiens_hsa047400.81922298
82Renin-angiotensin system_Homo sapiens_hsa046140.81156518
83Viral myocarditis_Homo sapiens_hsa054160.80798825
84Arachidonic acid metabolism_Homo sapiens_hsa005900.80217972
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80168323
86Pentose phosphate pathway_Homo sapiens_hsa000300.79338522
87Amphetamine addiction_Homo sapiens_hsa050310.78973571
88Bile secretion_Homo sapiens_hsa049760.78731562
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77182697
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76897988
91Fat digestion and absorption_Homo sapiens_hsa049750.76345194
92Phagosome_Homo sapiens_hsa041450.75915688
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.75467204
94Pyrimidine metabolism_Homo sapiens_hsa002400.74756838
95Primary immunodeficiency_Homo sapiens_hsa053400.74185187
96Base excision repair_Homo sapiens_hsa034100.73861006
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73671305
98Fructose and mannose metabolism_Homo sapiens_hsa000510.72829021
99Legionellosis_Homo sapiens_hsa051340.70651819
100Circadian entrainment_Homo sapiens_hsa047130.68229664
101Retinol metabolism_Homo sapiens_hsa008300.68072859
102Serotonergic synapse_Homo sapiens_hsa047260.67255663
103Salmonella infection_Homo sapiens_hsa051320.61950374
104Hematopoietic cell lineage_Homo sapiens_hsa046400.61307054
105Cocaine addiction_Homo sapiens_hsa050300.59838349
106Malaria_Homo sapiens_hsa051440.58407064
107Steroid biosynthesis_Homo sapiens_hsa001000.58043129
108Galactose metabolism_Homo sapiens_hsa000520.57133700
109Phototransduction_Homo sapiens_hsa047440.55652457
110Complement and coagulation cascades_Homo sapiens_hsa046100.55599233
111Herpes simplex infection_Homo sapiens_hsa051680.55555696
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54598782
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.54424649
114Rheumatoid arthritis_Homo sapiens_hsa053230.53879116
115Renin secretion_Homo sapiens_hsa049240.53546136
116Nitrogen metabolism_Homo sapiens_hsa009100.53434820
117One carbon pool by folate_Homo sapiens_hsa006700.53023163
118Glutamatergic synapse_Homo sapiens_hsa047240.52868495
119Pancreatic secretion_Homo sapiens_hsa049720.52789671
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52386940
121Biosynthesis of amino acids_Homo sapiens_hsa012300.52175973
122Mismatch repair_Homo sapiens_hsa034300.52162842
123Salivary secretion_Homo sapiens_hsa049700.51696597
124African trypanosomiasis_Homo sapiens_hsa051430.50105019
125Vitamin B6 metabolism_Homo sapiens_hsa007500.49486778
126Calcium signaling pathway_Homo sapiens_hsa040200.48843669
127Dopaminergic synapse_Homo sapiens_hsa047280.48345455
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48257737
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48125737
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44887285
131Vitamin digestion and absorption_Homo sapiens_hsa049770.44242608
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.43967808
133Glutathione metabolism_Homo sapiens_hsa004800.43108564
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42583354
135Mineral absorption_Homo sapiens_hsa049780.41459345
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40266796
137Regulation of autophagy_Homo sapiens_hsa041400.39846421
138Proteasome_Homo sapiens_hsa030500.38993129
139Gastric acid secretion_Homo sapiens_hsa049710.38272198
140Glycerolipid metabolism_Homo sapiens_hsa005610.37960003
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35427031
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35155245
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35101612
144Sulfur relay system_Homo sapiens_hsa041220.34784738

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