FUS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.00028028
2pre-miRNA processing (GO:0031054)4.37170507
33-UTR-mediated mRNA stabilization (GO:0070935)4.26419037
4regulation of histone H3-K27 methylation (GO:0061085)4.17018129
5negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.06070289
6negative regulation of mRNA processing (GO:0050686)3.85597527
7DNA topological change (GO:0006265)3.80632606
8positive regulation of RNA splicing (GO:0033120)3.71046909
9mitotic sister chromatid segregation (GO:0000070)3.68898841
10cytoplasmic mRNA processing body assembly (GO:0033962)3.65763047
11DNA strand elongation involved in DNA replication (GO:0006271)3.65120195
12regulation of mammary gland epithelial cell proliferation (GO:0033599)3.60983104
13DNA strand elongation (GO:0022616)3.55926684
14alternative mRNA splicing, via spliceosome (GO:0000380)3.55875795
15DNA replication initiation (GO:0006270)3.52596045
16regulation of translational fidelity (GO:0006450)3.51831678
17negative regulation of erythrocyte differentiation (GO:0045647)3.50151368
18regulation of NFAT protein import into nucleus (GO:0051532)3.50060929
19mRNA splice site selection (GO:0006376)3.49720868
20sister chromatid segregation (GO:0000819)3.48887140
21negative regulation of RNA splicing (GO:0033119)3.46841273
22DNA duplex unwinding (GO:0032508)3.45252859
23negative regulation of mRNA metabolic process (GO:1903312)3.42009375
24nuclear pore organization (GO:0006999)3.40573265
25mitotic sister chromatid cohesion (GO:0007064)3.38684305
26chromosome condensation (GO:0030261)3.38270339
27mRNA stabilization (GO:0048255)3.37581100
28RNA stabilization (GO:0043489)3.37581100
29histone H3-K4 trimethylation (GO:0080182)3.35881154
30lateral sprouting from an epithelium (GO:0060601)3.28489176
31planar cell polarity pathway involved in neural tube closure (GO:0090179)3.25586220
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.25060450
33DNA geometric change (GO:0032392)3.19784984
34dosage compensation (GO:0007549)3.14214997
35regulation of RNA export from nucleus (GO:0046831)3.12501428
36apoptotic process involved in morphogenesis (GO:0060561)3.11634596
37DNA conformation change (GO:0071103)3.07581882
38layer formation in cerebral cortex (GO:0021819)3.06961346
39head development (GO:0060322)3.05310902
40protein localization to chromosome, centromeric region (GO:0071459)3.04311897
41heterochromatin organization (GO:0070828)3.04287795
42cellular response to epidermal growth factor stimulus (GO:0071364)3.03534106
43peptidyl-lysine dimethylation (GO:0018027)3.03490770
44telomere maintenance via semi-conservative replication (GO:0032201)3.01627746
45glucocorticoid receptor signaling pathway (GO:0042921)2.99385241
46regulation of somitogenesis (GO:0014807)2.98458465
47protein complex localization (GO:0031503)2.97152214
48regulation of chromatin binding (GO:0035561)2.96680304
49pore complex assembly (GO:0046931)2.94820121
50cytoskeletal anchoring at plasma membrane (GO:0007016)2.94383262
51protein export from nucleus (GO:0006611)2.93628402
52* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.93066777
53* mRNA splicing, via spliceosome (GO:0000398)2.93066777
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89897657
55mitotic nuclear envelope disassembly (GO:0007077)2.89631340
56cellular protein complex localization (GO:0034629)2.86002540
57ribosomal small subunit biogenesis (GO:0042274)2.85042844
58* RNA splicing, via transesterification reactions (GO:0000375)2.82731515
59negative regulation of translation, ncRNA-mediated (GO:0040033)2.82654352
60regulation of translation, ncRNA-mediated (GO:0045974)2.82654352
61negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82654352
62membrane disassembly (GO:0030397)2.82570759
63nuclear envelope disassembly (GO:0051081)2.82570759
64convergent extension (GO:0060026)2.82559798
65mRNA transport (GO:0051028)2.82024467
66regulation of DNA damage checkpoint (GO:2000001)2.81112028
67modulation by virus of host process (GO:0019054)2.77925872
68mannose metabolic process (GO:0006013)2.77138300
69DNA packaging (GO:0006323)2.76950275
70regulation of mRNA stability (GO:0043488)2.76204007
71histone H3-K4 methylation (GO:0051568)2.73589412
72G1 DNA damage checkpoint (GO:0044783)2.72244318
73mitotic G1 DNA damage checkpoint (GO:0031571)2.70667976
74protein localization to kinetochore (GO:0034501)2.69756022
75proline biosynthetic process (GO:0006561)2.68855040
76negative regulation of histone methylation (GO:0031061)2.68216549
77trophectodermal cell differentiation (GO:0001829)2.67885871
78histone arginine methylation (GO:0034969)2.67821540
79regulation of nucleobase-containing compound transport (GO:0032239)2.67683854
80polarized epithelial cell differentiation (GO:0030859)2.66459644
81positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.66127077
82response to epidermal growth factor (GO:0070849)2.65340093
83regulation of histone methylation (GO:0031060)2.65140663
84NLS-bearing protein import into nucleus (GO:0006607)2.64640428
85insulin-like growth factor receptor signaling pathway (GO:0048009)2.64379024
86cellular hyperosmotic response (GO:0071474)2.63240271
87intracellular estrogen receptor signaling pathway (GO:0030520)2.63202809
88mRNA export from nucleus (GO:0006406)2.62568963
89stress granule assembly (GO:0034063)2.61830197
90regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.60538839
91maternal placenta development (GO:0001893)2.60510513
92hippo signaling (GO:0035329)2.60222407
93positive regulation of DNA-dependent DNA replication (GO:2000105)2.59719304
94V(D)J recombination (GO:0033151)2.57896549
95nuclear envelope organization (GO:0006998)2.57680549
96peptidyl-lysine trimethylation (GO:0018023)2.57663575
97chromatin assembly (GO:0031497)2.56952334
98establishment of nucleus localization (GO:0040023)2.56681035
99folic acid-containing compound biosynthetic process (GO:0009396)2.56514356
100gastrulation with mouth forming second (GO:0001702)2.55852292
101maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55274054
102Golgi transport vesicle coating (GO:0048200)2.53842822
103COPI coating of Golgi vesicle (GO:0048205)2.53842822
104poly(A)+ mRNA export from nucleus (GO:0016973)2.53818914
105positive regulation of histone deacetylation (GO:0031065)2.53502451
106cell migration in hindbrain (GO:0021535)2.52983912
107negative regulation of catenin import into nucleus (GO:0035414)2.52902127
108positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.51180868
109regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.51180868
110regulation of establishment of planar polarity (GO:0090175)2.51059068
111regulation of RNA stability (GO:0043487)2.50530874
112paraxial mesoderm development (GO:0048339)2.49586431
113Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.48006051
114positive regulation of gene expression, epigenetic (GO:0045815)2.46814166
115DNA unwinding involved in DNA replication (GO:0006268)2.46791974
116proximal/distal pattern formation (GO:0009954)2.41346660
117adherens junction assembly (GO:0034333)2.40949789
118positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.40581366
119regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.40581366
120histone H4-K16 acetylation (GO:0043984)2.39533201
121histone lysine methylation (GO:0034968)2.37746653
122establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.37043292
123protein-DNA complex disassembly (GO:0032986)2.36817443
124nucleosome disassembly (GO:0006337)2.36817443
125regulation of histone H3-K4 methylation (GO:0051569)2.35362317
126corticosteroid receptor signaling pathway (GO:0031958)2.34766671
127neural tube closure (GO:0001843)2.33173207
128spliceosomal tri-snRNP complex assembly (GO:0000244)2.33143289
129cortical actin cytoskeleton organization (GO:0030866)2.32793073
130body morphogenesis (GO:0010171)2.32462943
131nuclear pore complex assembly (GO:0051292)2.32202376
132tube closure (GO:0060606)2.31111199
133positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.30591278
134regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.29740525
135peptidyl-arginine omega-N-methylation (GO:0035247)2.27480841
136heart morphogenesis (GO:0003007)2.26524640
137establishment of tissue polarity (GO:0007164)2.26368377
138establishment of planar polarity (GO:0001736)2.26368377
139dendritic spine morphogenesis (GO:0060997)2.25842879
140histone H3-K36 demethylation (GO:0070544)2.24680157
141histone methylation (GO:0016571)2.24138778
142peptidyl-arginine methylation (GO:0018216)2.22289291
143peptidyl-arginine N-methylation (GO:0035246)2.22289291
144glial cell proliferation (GO:0014009)2.21569576
145establishment of apical/basal cell polarity (GO:0035089)2.20422868
146negative regulation of glial cell proliferation (GO:0060253)2.19986759
147histone H3-K9 methylation (GO:0051567)2.19651520
148gonadal mesoderm development (GO:0007506)2.18860529
149chromatin silencing (GO:0006342)2.18547753
150non-canonical Wnt signaling pathway (GO:0035567)2.18114245
151negative regulation of cell killing (GO:0031342)2.17807749
152negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.17807749
153peptidyl-lysine methylation (GO:0018022)2.17728207
154locomotory exploration behavior (GO:0035641)2.17281444
155positive regulation of dendrite morphogenesis (GO:0050775)2.16633087
156positive thymic T cell selection (GO:0045059)2.16182710
157sodium ion export (GO:0071436)2.16092818
158cochlea morphogenesis (GO:0090103)2.15841603
159regulation of RNA splicing (GO:0043484)2.15764696
160focal adhesion assembly (GO:0048041)2.13304624
161cell-substrate adherens junction assembly (GO:0007045)2.13304624
162regulation of mRNA splicing, via spliceosome (GO:0048024)2.13064548
163neuronal stem cell maintenance (GO:0097150)2.11899311
164regulation of mRNA 3-end processing (GO:0031440)2.11444654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.59978055
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.13025124
3E2F7_22180533_ChIP-Seq_HELA_Human3.35966573
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.10315833
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93927001
6MYC_22102868_ChIP-Seq_BL_Human2.76805686
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.67559764
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67081562
9KDM2B_26808549_Chip-Seq_DND41_Human2.58869990
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.52769749
11ZFP281_27345836_Chip-Seq_ESCs_Mouse2.48405343
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.44999852
13* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.44739812
14* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.44468406
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.40354501
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37505942
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.32120343
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21593803
19KDM2B_26808549_Chip-Seq_JURKAT_Human2.20369545
20TCF7_22412390_ChIP-Seq_EML_Mouse2.16806840
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.15273448
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13842744
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.05917834
24* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03150964
25DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.01920922
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01782091
27KDM2B_26808549_Chip-Seq_K562_Human2.01282197
28EZH2_22144423_ChIP-Seq_EOC_Human1.97644670
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97016532
30VDR_21846776_ChIP-Seq_THP-1_Human1.96869150
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.95829398
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.93745091
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88644482
34* XRN2_22483619_ChIP-Seq_HELA_Human1.76604680
35PKCTHETA_26484144_Chip-Seq_BREAST_Human1.74494127
36* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73495154
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73060869
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72642956
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69014164
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.67633911
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63014329
42FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.61281582
43* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59896341
44* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58754719
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.57906506
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.57132682
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56391153
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56391153
49* ELK3_25401928_ChIP-Seq_HUVEC_Human1.54658598
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54455907
51CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.54163264
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53766689
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.51104828
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50858678
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.49467516
56DROSHA_22980978_ChIP-Seq_HELA_Human1.46072315
57* E2F1_21310950_ChIP-Seq_MCF-7_Human1.45791559
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43521435
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41653949
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41425674
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39949977
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39629274
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.39332702
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37412978
65CREB1_26743006_Chip-Seq_LNCaP_Human1.36075501
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34259627
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34172639
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.32289410
69* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31450995
70MAF_26560356_Chip-Seq_TH2_Human1.31406576
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31186975
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.28672532
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28515896
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28515896
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28515896
76* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27278036
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26221742
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25281522
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.25002766
80* UTX_26944678_Chip-Seq_JUKART_Human1.23546191
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22989111
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22896093
83LXR_22292898_ChIP-Seq_THP-1_Human1.21770590
84AR_21909140_ChIP-Seq_LNCAP_Human1.21133493
85* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20132570
86P68_20966046_ChIP-Seq_HELA_Human1.19514393
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18739928
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18524409
89AR_21572438_ChIP-Seq_LNCaP_Human1.17601562
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16450811
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.16217103
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15242661
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14911415
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.14859822
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14419246
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14093657
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13730217
98THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13375773
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12471878
100TP53_20018659_ChIP-ChIP_R1E_Mouse1.12168238
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11310471
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10753634
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.10670435
104CIITA_25753668_ChIP-Seq_RAJI_Human1.09889604
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09740421
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08452988
107* KDM5A_27292631_Chip-Seq_BREAST_Human1.06586389
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05867018
109SMC4_20622854_ChIP-Seq_HELA_Human1.04642065
110* TTF2_22483619_ChIP-Seq_HELA_Human1.03573302
111RACK7_27058665_Chip-Seq_MCF-7_Human1.02319485
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02203932
113RUNX1_27514584_Chip-Seq_MCF-7_Human1.02097057
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01803234
115POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01461403
116TP53_16413492_ChIP-PET_HCT116_Human1.01315867
117* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01263465
118* NCOR1_26117541_ChIP-Seq_K562_Human0.99486859
119* MAF_26560356_Chip-Seq_TH1_Human0.99216350
120* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98844013
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98787924
122* VDR_24763502_ChIP-Seq_THP-1_Human0.98401418
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97991934
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97803002
125RUNX1_22412390_ChIP-Seq_EML_Mouse0.97799351
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.97455089
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97219683
128STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96996633
129SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96890321
130DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96806548
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96794782
132WT1_19549856_ChIP-ChIP_CCG9911_Human0.96583499
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96177365
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95907367
135SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95867699
136SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95193179
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94560881
138EED_16625203_ChIP-ChIP_MESCs_Mouse0.94175709
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93914826
140EZH2_27294783_Chip-Seq_ESCs_Mouse0.93685350
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93409161
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92863783
143CHD1_26751641_Chip-Seq_LNCaP_Human0.91871441
144TP53_22127205_ChIP-Seq_IMR90_Human0.91867924
145* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91185941
146ZNF263_19887448_ChIP-Seq_K562_Human0.90957307
147* CLOCK_20551151_ChIP-Seq_293T_Human0.90900898
148MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90884741
149SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90800502
150* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88967557
151SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87593286
152TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.86192425
153HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85742442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching2.98530077
2MP0005076_abnormal_cell_differentiation2.94492803
3MP0002396_abnormal_hematopoietic_system2.90055286
4* MP0010094_abnormal_chromosome_stability2.67392827
5MP0003077_abnormal_cell_cycle2.48456047
6MP0000537_abnormal_urethra_morphology2.38572726
7MP0004957_abnormal_blastocyst_morpholog2.37235353
8MP0005451_abnormal_body_composition2.21810649
9MP0009278_abnormal_bone_marrow2.19511458
10MP0003122_maternal_imprinting2.13596165
11MP0000569_abnormal_digit_pigmentation2.10191466
12MP0003705_abnormal_hypodermis_morpholog2.07111375
13MP0003121_genomic_imprinting2.05196020
14MP0008961_abnormal_basal_metabolism2.01843968
15MP0005623_abnormal_meninges_morphology1.98912412
16MP0003123_paternal_imprinting1.97126798
17MP0002877_abnormal_melanocyte_morpholog1.90852939
18MP0003385_abnormal_body_wall1.88186644
19MP0010030_abnormal_orbit_morphology1.87374935
20MP0000428_abnormal_craniofacial_morphol1.87298280
21MP0002089_abnormal_postnatal_growth/wei1.81654965
22MP0000733_abnormal_muscle_development1.80539714
23MP0009053_abnormal_anal_canal1.79016835
24MP0003303_peritoneal_inflammation1.77517794
25MP0004859_abnormal_synaptic_plasticity1.77432643
26MP0008932_abnormal_embryonic_tissue1.76145876
27MP0004197_abnormal_fetal_growth/weight/1.68513866
28MP0003787_abnormal_imprinting1.65199130
29MP0004858_abnormal_nervous_system1.65047032
30MP0001348_abnormal_lacrimal_gland1.63343287
31MP0002084_abnormal_developmental_patter1.61927835
32MP0002009_preneoplasia1.58451856
33MP0003763_abnormal_thymus_physiology1.54677350
34MP0003935_abnormal_craniofacial_develop1.54259361
35MP0000566_synostosis1.51948517
36MP0003283_abnormal_digestive_organ1.49674926
37MP0003115_abnormal_respiratory_system1.47793425
38MP0003119_abnormal_digestive_system1.47377938
39MP0002085_abnormal_embryonic_tissue1.46754242
40MP0003861_abnormal_nervous_system1.46118199
41MP0005187_abnormal_penis_morphology1.44420499
42MP0001346_abnormal_lacrimal_gland1.40203501
43MP0000778_abnormal_nervous_system1.39617502
44MP0003755_abnormal_palate_morphology1.39495259
45MP0010307_abnormal_tumor_latency1.37466545
46MP0010352_gastrointestinal_tract_polyps1.37391757
47MP0000313_abnormal_cell_death1.35952267
48MP0003567_abnormal_fetal_cardiomyocyte1.35029116
49MP0002932_abnormal_joint_morphology1.34303101
50MP0003937_abnormal_limbs/digits/tail_de1.32726247
51MP0008007_abnormal_cellular_replicative1.31323877
52MP0003938_abnormal_ear_development1.31278366
53MP0002697_abnormal_eye_size1.29443218
54MP0001849_ear_inflammation1.29431487
55MP0008057_abnormal_DNA_replication1.28967136
56MP0010678_abnormal_skin_adnexa1.27593387
57MP0004264_abnormal_extraembryonic_tissu1.26231193
58MP0009703_decreased_birth_body1.24561417
59MP0005409_darkened_coat_color1.24440507
60MP0004185_abnormal_adipocyte_glucose1.24172208
61MP0000383_abnormal_hair_follicle1.22930804
62MP0002116_abnormal_craniofacial_bone1.22421655
63MP0005621_abnormal_cell_physiology1.22296977
64MP0009333_abnormal_splenocyte_physiolog1.20072981
65MP0000049_abnormal_middle_ear1.20059525
66MP0005380_embryogenesis_phenotype1.19720952
67MP0001672_abnormal_embryogenesis/_devel1.19720952
68MP0003890_abnormal_embryonic-extraembry1.19362757
69MP0000432_abnormal_head_morphology1.18955887
70MP0003942_abnormal_urinary_system1.18210794
71MP0002925_abnormal_cardiovascular_devel1.18057291
72MP0009672_abnormal_birth_weight1.17877827
73MP0005666_abnormal_adipose_tissue1.16114805
74MP0000350_abnormal_cell_proliferation1.15222936
75MP0000490_abnormal_crypts_of1.14637347
76MP0002088_abnormal_embryonic_growth/wei1.14417727
77MP0000678_abnormal_parathyroid_gland1.14333661
78MP0003984_embryonic_growth_retardation1.13683648
79MP0005058_abnormal_lysosome_morphology1.13368089
80MP0005257_abnormal_intraocular_pressure1.12609043
81MP0004272_abnormal_basement_membrane1.12348536
82MP0000003_abnormal_adipose_tissue1.10515185
83MP0002234_abnormal_pharynx_morphology1.10236101
84MP0003300_gastrointestinal_ulcer1.10153289
85MP0001730_embryonic_growth_arrest1.09985931
86MP0002086_abnormal_extraembryonic_tissu1.07778381
87MP0001697_abnormal_embryo_size1.06861626
88MP0004233_abnormal_muscle_weight1.06850678
89MP0002249_abnormal_larynx_morphology1.06175884
90MP0002114_abnormal_axial_skeleton1.05838780
91MP0002092_abnormal_eye_morphology1.03985426
92* MP0002081_perinatal_lethality1.03751650
93MP0002398_abnormal_bone_marrow1.03054064
94MP0003091_abnormal_cell_migration1.02944664
95MP0002653_abnormal_ependyma_morphology1.02383355
96MP0001293_anophthalmia1.01905213
97MP0001545_abnormal_hematopoietic_system1.01537801
98MP0005397_hematopoietic_system_phenotyp1.01537801
99MP0000534_abnormal_ureter_morphology1.00950996
100MP0000751_myopathy1.00214685
101MP0010234_abnormal_vibrissa_follicle1.00213262
102MP0004885_abnormal_endolymph1.00142712
103MP0001286_abnormal_eye_development0.99807043
104MP0009250_abnormal_appendicular_skeleto0.99647687
105MP0002019_abnormal_tumor_incidence0.99434373
106MP0001299_abnormal_eye_distance/0.98456597
107MP0003453_abnormal_keratinocyte_physiol0.96959190
108MP0002111_abnormal_tail_morphology0.96758230
109MP0008770_decreased_survivor_rate0.96730628
110* MP0002152_abnormal_brain_morphology0.96444531
111MP0001784_abnormal_fluid_regulation0.93789428
112MP0010630_abnormal_cardiac_muscle0.93490210
113MP0000858_altered_metastatic_potential0.93335201
114MP0004808_abnormal_hematopoietic_stem0.90687413
115MP0001340_abnormal_eyelid_morphology0.90588922
116MP0002282_abnormal_trachea_morphology0.89907456
117MP0001915_intracranial_hemorrhage0.88739593
118MP0003635_abnormal_synaptic_transmissio0.87927884
119MP0005384_cellular_phenotype0.86869059
120* MP0003111_abnormal_nucleus_morphology0.86655320
121MP0005248_abnormal_Harderian_gland0.86500481
122MP0005375_adipose_tissue_phenotype0.84865708
123MP0005423_abnormal_somatic_nervous0.84420322
124MP0002233_abnormal_nose_morphology0.83766394
125MP0002080_prenatal_lethality0.83489029
126MP0005501_abnormal_skin_physiology0.83198252
127MP0003941_abnormal_skin_development0.82806759
128MP0003172_abnormal_lysosome_physiology0.81334957
129MP0002166_altered_tumor_susceptibility0.81178071
130MP0003566_abnormal_cell_adhesion0.81045115
131MP0008438_abnormal_cutaneous_collagen0.80107117
132MP0004947_skin_inflammation0.79511162
133MP0000477_abnormal_intestine_morphology0.79416563
134* MP0002722_abnormal_immune_system0.79367820
135MP0008058_abnormal_DNA_repair0.79139469
136MP0000467_abnormal_esophagus_morphology0.78575715
137MP0001853_heart_inflammation0.78411535
138MP0000631_abnormal_neuroendocrine_gland0.77939567
139MP0008260_abnormal_autophagy0.77768205
140MP0000462_abnormal_digestive_system0.76508172
141MP0002970_abnormal_white_adipose0.76042101
142MP0003315_abnormal_perineum_morphology0.75217008
143MP0000266_abnormal_heart_morphology0.75005443
144MP0008569_lethality_at_weaning0.74584837
145MP0000955_abnormal_spinal_cord0.73769003
146* MP0000703_abnormal_thymus_morphology0.71037653

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.45402153
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.45402153
3Hyperacusis (HP:0010780)3.42901754
4Renal duplication (HP:0000075)3.03752474
5Shallow orbits (HP:0000586)2.93702679
6Abnormality of the 4th metacarpal (HP:0010012)2.87086686
7Overriding aorta (HP:0002623)2.82126368
8Macroorchidism (HP:0000053)2.81043766
9Elfin facies (HP:0004428)2.69780514
10Broad face (HP:0000283)2.59466867
11Long palpebral fissure (HP:0000637)2.56276541
12Insomnia (HP:0100785)2.54415632
13Increased nuchal translucency (HP:0010880)2.52875264
14Supernumerary ribs (HP:0005815)2.50394632
15Renovascular hypertension (HP:0100817)2.49382483
16Progressive muscle weakness (HP:0003323)2.47069870
17Obstructive sleep apnea (HP:0002870)2.45614487
18Neoplasm of the heart (HP:0100544)2.42011044
19Abnormality of the fingertips (HP:0001211)2.37482520
20Trigonocephaly (HP:0000243)2.36599286
21Pointed chin (HP:0000307)2.35787323
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31642451
23Volvulus (HP:0002580)2.27212574
24Selective tooth agenesis (HP:0001592)2.24519243
25Broad palm (HP:0001169)2.23884306
26Broad distal phalanx of finger (HP:0009836)2.23756343
27Cerebral aneurysm (HP:0004944)2.22710320
28Abnormality of the diencephalon (HP:0010662)2.22210080
29Dysmetric saccades (HP:0000641)2.22165800
30Abnormality of the calcaneus (HP:0008364)2.21674884
31Obsessive-compulsive behavior (HP:0000722)2.20850899
32Syringomyelia (HP:0003396)2.20610782
33Spinal cord lesions (HP:0100561)2.20610782
34Arnold-Chiari malformation (HP:0002308)2.19191631
35Dislocated radial head (HP:0003083)2.17427406
36Heterotopia (HP:0002282)2.17107490
37Supernumerary bones of the axial skeleton (HP:0009144)2.16851507
38Overlapping toe (HP:0001845)2.15906095
39Long eyelashes (HP:0000527)2.13947574
40Protrusio acetabuli (HP:0003179)2.13786016
41Ependymoma (HP:0002888)2.12894212
42Chromsome breakage (HP:0040012)2.12603609
43Flat cornea (HP:0007720)2.12451925
44Deep palmar crease (HP:0006191)2.11212939
45Biconcave vertebral bodies (HP:0004586)2.10637926
46Bladder diverticulum (HP:0000015)2.10224985
47Abnormal number of incisors (HP:0011064)2.08493240
48Broad thumb (HP:0011304)2.06441742
49Bronchomalacia (HP:0002780)2.04344254
50Narrow palate (HP:0000189)2.04001223
51High anterior hairline (HP:0009890)2.03446344
52Astrocytoma (HP:0009592)2.00878566
53Abnormality of the astrocytes (HP:0100707)2.00878566
54Bowel diverticulosis (HP:0005222)1.99701213
55Abnormality of the radial head (HP:0003995)1.98706321
56Spina bifida occulta (HP:0003298)1.97076687
57Thin ribs (HP:0000883)1.97035895
58Rectal prolapse (HP:0002035)1.96912812
59Abnormality of the parietal bone (HP:0002696)1.96614378
60Proximal placement of thumb (HP:0009623)1.95992853
61Large earlobe (HP:0009748)1.95497583
62Mitral valve prolapse (HP:0001634)1.93611832
63Sacral dimple (HP:0000960)1.92703667
64Metaphyseal cupping (HP:0003021)1.92178048
65Ulnar bowing (HP:0003031)1.90080157
66Esophageal atresia (HP:0002032)1.89768928
67Deviation of the hallux (HP:0010051)1.89338544
68Abnormality of the thoracic spine (HP:0100711)1.88706578
69Skull defect (HP:0001362)1.88358780
70Vertebral arch anomaly (HP:0008438)1.87871217
71Midline defect of the nose (HP:0004122)1.87383449
72Centrally nucleated skeletal muscle fibers (HP:0003687)1.85055248
73Hallux valgus (HP:0001822)1.84616619
74Flat acetabular roof (HP:0003180)1.84358923
75Persistence of primary teeth (HP:0006335)1.83755679
76Disproportionate tall stature (HP:0001519)1.83668291
77Flared metaphyses (HP:0003015)1.83470324
78Broad metatarsal (HP:0001783)1.83403814
79Sparse lateral eyebrow (HP:0005338)1.82430157
80Abnormality of the columella (HP:0009929)1.82299227
81Achilles tendon contracture (HP:0001771)1.82257523
82Deviation of the thumb (HP:0009603)1.81436745
83Buphthalmos (HP:0000557)1.79455208
84Progressive external ophthalmoplegia (HP:0000590)1.77050746
85Ankyloglossia (HP:0010296)1.76933860
86Myelomeningocele (HP:0002475)1.76320193
87Patellar dislocation (HP:0002999)1.76179042
88Abnormality of the phalanges of the hallux (HP:0010057)1.75488203
89Short phalanx of the thumb (HP:0009660)1.74878038
90Neoplasm of the oral cavity (HP:0100649)1.74314355
91Segmental peripheral demyelination/remyelination (HP:0003481)1.73961553
92Vertebral fusion (HP:0002948)1.73790471
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71602010
94Preauricular skin tag (HP:0000384)1.71480713
95* Pseudobulbar signs (HP:0002200)1.70773060
96Coronal craniosynostosis (HP:0004440)1.69967273
97Deep philtrum (HP:0002002)1.69518539
98Abnormality of the intervertebral disk (HP:0005108)1.69470084
99Vesicoureteral reflux (HP:0000076)1.69242004
100Trismus (HP:0000211)1.68339889
101Increased density of long bones (HP:0006392)1.67910866
102Termporal pattern (HP:0011008)1.67821295
103Insidious onset (HP:0003587)1.67821295
104Broad phalanges of the hand (HP:0009768)1.67662269
105Abnormality of the humeroradial joint (HP:0100744)1.67643594
106Abnormality of the lower motor neuron (HP:0002366)1.66881779
107Skin tags (HP:0010609)1.66366868
108Premature rupture of membranes (HP:0001788)1.66322999
109Limited elbow extension (HP:0001377)1.66286188
110Facial hemangioma (HP:0000329)1.66020498
111Atresia of the external auditory canal (HP:0000413)1.65136826
112Abnormality of cochlea (HP:0000375)1.64812137
113Abnormality of oral frenula (HP:0000190)1.64190631
114Scapular winging (HP:0003691)1.64024307
115Annular pancreas (HP:0001734)1.63792085
116Broad finger (HP:0001500)1.63624487
117Duplication of thumb phalanx (HP:0009942)1.63292822
118Premature skin wrinkling (HP:0100678)1.62745405
119Partial duplication of thumb phalanx (HP:0009944)1.62234577
120Hemivertebrae (HP:0002937)1.62186226
121Distal lower limb amyotrophy (HP:0008944)1.61441975
122Medulloblastoma (HP:0002885)1.60996435
123Midface retrusion (HP:0011800)1.60017518
124Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.58671724
125Anteriorly placed anus (HP:0001545)1.58553728
126Small epiphyses (HP:0010585)1.56853914
127Urethral obstruction (HP:0000796)1.56779994
128Acute lymphatic leukemia (HP:0006721)1.56768916
129Hypoplasia of the maxilla (HP:0000327)1.55593099
130Megalocornea (HP:0000485)1.55319970
131Gastrointestinal carcinoma (HP:0002672)1.54835019
132Malignant gastrointestinal tract tumors (HP:0006749)1.54835019
133Neoplasm of striated muscle (HP:0009728)1.54782092
134Abnormality of the distal phalanx of the thumb (HP:0009617)1.54305445
135Abnormality of the Achilles tendon (HP:0005109)1.54216282
136Genetic anticipation (HP:0003743)1.53996607
137Mitral regurgitation (HP:0001653)1.53723069
138Genu recurvatum (HP:0002816)1.53583476
139Asymmetry of the thorax (HP:0001555)1.52746849
140Cupped ribs (HP:0000887)1.52724763
141Self-mutilation (HP:0000742)1.52620365
142Abnormality of the labia minora (HP:0012880)1.52399582
143Anal stenosis (HP:0002025)1.52191701
144Calcaneovalgus deformity (HP:0001848)1.52177743
145Abnormality of the salivary glands (HP:0010286)1.52124303
146Turricephaly (HP:0000262)1.51961447
147Precocious puberty (HP:0000826)1.51918192
148Thick eyebrow (HP:0000574)1.51615300
149Abnormality of the antihelix (HP:0009738)1.51170370
150Abnormality of the nasal septum (HP:0000419)1.50755652
151Hypoplastic ischia (HP:0003175)1.50282197
152Abnormality of chromosome segregation (HP:0002916)1.50243383
153Bowel incontinence (HP:0002607)1.48857917
154Attention deficit hyperactivity disorder (HP:0007018)1.48525234
155Broad phalanx (HP:0006009)1.47946708
156Absent frontal sinuses (HP:0002688)1.47388668
157Broad toe (HP:0001837)1.45634815

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.50087465
2SMG14.28283013
3BRD43.53326005
4MAP3K102.95542609
5EEF2K2.85685427
6PRPF4B2.84948535
7SIK22.55428953
8CAMK1G2.54020052
9FGFR42.53982376
10ICK2.44110109
11TRIB32.30462386
12PNCK2.14040854
13ALK2.02733007
14ERN12.02217186
15PKN21.90623857
16TYRO31.89465093
17CAMK1D1.73052866
18PDGFRA1.72209386
19CDC71.69106157
20MKNK21.60854440
21MKNK11.59381592
22PTK61.57677311
23MAP3K131.48731635
24TTN1.43060070
25MTOR1.39096828
26NME21.38779441
27VRK21.37535206
28RIPK11.36654846
29LATS11.35966829
30UHMK11.32848993
31CDK61.29379970
32FGFR21.28880905
33WNK11.28506434
34BMX1.22339402
35DMPK1.22127626
36IRAK31.18079312
37DDR21.15837027
38PAK21.12821174
39PDGFRB1.10196647
40CDC42BPA1.09864739
41MAP3K141.02054709
42MAP4K11.01049145
43MAPK111.00691297
44MARK21.00387680
45NEK21.00260273
46SRPK10.99858350
47EPHB10.98607104
48CDK90.98583182
49EPHB20.97051873
50NTRK20.96690466
51CDK40.96455485
52SIK10.94100410
53PAK60.93290930
54PASK0.92937160
55LATS20.92735196
56CHEK20.91771282
57MAP3K40.90527990
58RPS6KB20.90265636
59STK110.85258269
60FES0.84413740
61BUB10.83351421
62NTRK30.83097801
63FGFR10.82422105
64PRKD30.81787114
65PRKD20.80764979
66MAP3K70.80375282
67TAOK10.79885016
68CLK10.78594222
69FGR0.78185396
70TAF10.77719687
71MAP3K80.77334039
72MAP3K90.76992682
73CDK70.74250062
74STK100.73450100
75CHEK10.73390122
76PRKCH0.70068273
77TAOK20.69642175
78CSNK1A1L0.68995006
79TESK20.68722175
80RET0.67914734
81PAK40.67818179
82CDK20.66470357
83CSNK1E0.65982565
84PTK20.65967824
85ERBB20.65559148
86CSNK1D0.64584862
87KSR10.64498020
88MAPK100.62857447
89WEE10.62561010
90SCYL20.61679397
91HIPK20.60540796
92RPS6KA20.60423922
93MAP2K30.59840146
94MAP2K20.59590535
95MELK0.59342969
96STK30.59213292
97ROCK20.57833078
98KSR20.57804249
99RPS6KL10.57153832
100RPS6KC10.57153832
101MAPK140.56696111
102* PRKDC0.56650400
103HCK0.56372370
104GSK3B0.55821416
105CDK10.55682567
106DYRK1B0.54564124
107LRRK20.53015047
108PRKD10.51330078
109CDK80.50077390
110SIK30.49817585
111MAPK80.49354053
112NTRK10.49181287
113MAPK90.48219746
114ITK0.48170069
115DYRK1A0.46945569
116EPHA40.46804518
117* ATM0.46392924
118AURKB0.45505288
119CDK11A0.45368955
120MAPK10.44951556
121CAMK40.43865728
122STK380.42278079
123TTK0.42205528
124ATR0.41857838
125CDK150.41303489
126FYN0.39807042
127MARK10.39149351
128SRC0.39083802
129RPS6KA10.38925660
130RPS6KA60.38808864
131MAP3K10.38072057
132BRSK10.37614929
133AKT10.36829484
134JAK30.36380515
135RPS6KA30.35621072
136FGFR30.35482515
137CDK180.33791135
138AURKA0.33380235
139RIPK40.32702443

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.43896036
2Base excision repair_Homo sapiens_hsa034102.12869393
3Basal cell carcinoma_Homo sapiens_hsa052171.86284769
4Thyroid cancer_Homo sapiens_hsa052161.80263859
5Dorso-ventral axis formation_Homo sapiens_hsa043201.69810978
6Lysine degradation_Homo sapiens_hsa003101.65838512
7Chronic myeloid leukemia_Homo sapiens_hsa052201.65770914
8Hedgehog signaling pathway_Homo sapiens_hsa043401.63027159
9Notch signaling pathway_Homo sapiens_hsa043301.61082295
10Axon guidance_Homo sapiens_hsa043601.60979344
11mRNA surveillance pathway_Homo sapiens_hsa030151.59021067
12MicroRNAs in cancer_Homo sapiens_hsa052061.51367971
13Mismatch repair_Homo sapiens_hsa034301.49745422
14Glioma_Homo sapiens_hsa052141.40433118
15RNA transport_Homo sapiens_hsa030131.36815128
16Colorectal cancer_Homo sapiens_hsa052101.36549615
17Hippo signaling pathway_Homo sapiens_hsa043901.36039224
18Renal cell carcinoma_Homo sapiens_hsa052111.35951136
19mTOR signaling pathway_Homo sapiens_hsa041501.35331538
20Proteoglycans in cancer_Homo sapiens_hsa052051.35102616
21Wnt signaling pathway_Homo sapiens_hsa043101.33623606
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32357761
23Estrogen signaling pathway_Homo sapiens_hsa049151.32120451
24Long-term potentiation_Homo sapiens_hsa047201.29507056
25Thyroid hormone signaling pathway_Homo sapiens_hsa049191.28385045
26Non-small cell lung cancer_Homo sapiens_hsa052231.28363324
27One carbon pool by folate_Homo sapiens_hsa006701.28186368
28Biosynthesis of amino acids_Homo sapiens_hsa012301.27110384
29Adherens junction_Homo sapiens_hsa045201.25702446
30Other glycan degradation_Homo sapiens_hsa005111.25595320
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23976232
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22372176
33Hepatitis B_Homo sapiens_hsa051611.21630200
34ErbB signaling pathway_Homo sapiens_hsa040121.21045576
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20843846
36Type II diabetes mellitus_Homo sapiens_hsa049301.19923248
37Endometrial cancer_Homo sapiens_hsa052131.19885022
38Spliceosome_Homo sapiens_hsa030401.17918601
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15534870
40GnRH signaling pathway_Homo sapiens_hsa049121.15317211
41Melanogenesis_Homo sapiens_hsa049161.15145136
42Focal adhesion_Homo sapiens_hsa045101.14968792
43VEGF signaling pathway_Homo sapiens_hsa043701.14887828
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.14664597
45Herpes simplex infection_Homo sapiens_hsa051681.14330720
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12750299
47Small cell lung cancer_Homo sapiens_hsa052221.12290112
48Gastric acid secretion_Homo sapiens_hsa049711.11953546
49Long-term depression_Homo sapiens_hsa047301.11514216
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10878207
51Gap junction_Homo sapiens_hsa045401.10708055
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10610979
53Pentose phosphate pathway_Homo sapiens_hsa000301.10562647
54Nucleotide excision repair_Homo sapiens_hsa034201.09341007
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08360347
56Oxytocin signaling pathway_Homo sapiens_hsa049211.08160278
57B cell receptor signaling pathway_Homo sapiens_hsa046621.07827724
58Glutamatergic synapse_Homo sapiens_hsa047241.07288125
59Prion diseases_Homo sapiens_hsa050201.07031988
60Viral myocarditis_Homo sapiens_hsa054161.06414216
61T cell receptor signaling pathway_Homo sapiens_hsa046601.05462435
62Epstein-Barr virus infection_Homo sapiens_hsa051691.04062095
63Prostate cancer_Homo sapiens_hsa052151.03806688
64Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03609111
65Fructose and mannose metabolism_Homo sapiens_hsa000511.03364556
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03359753
67Phospholipase D signaling pathway_Homo sapiens_hsa040721.02338104
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00686762
69Renin secretion_Homo sapiens_hsa049241.00213638
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.99789228
71Viral carcinogenesis_Homo sapiens_hsa052030.99767748
72Apoptosis_Homo sapiens_hsa042100.99349005
73Choline metabolism in cancer_Homo sapiens_hsa052310.98792438
74Dilated cardiomyopathy_Homo sapiens_hsa054140.97914031
75Circadian entrainment_Homo sapiens_hsa047130.97753870
76Dopaminergic synapse_Homo sapiens_hsa047280.97203952
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96437107
78ECM-receptor interaction_Homo sapiens_hsa045120.96089092
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95305291
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95070540
81Pancreatic cancer_Homo sapiens_hsa052120.94901630
82Cocaine addiction_Homo sapiens_hsa050300.94730994
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94655628
84HTLV-I infection_Homo sapiens_hsa051660.94380836
85Pathways in cancer_Homo sapiens_hsa052000.94308020
86Rap1 signaling pathway_Homo sapiens_hsa040150.93748321
87MAPK signaling pathway_Homo sapiens_hsa040100.92994574
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91531169
89TGF-beta signaling pathway_Homo sapiens_hsa043500.91402817
90Oocyte meiosis_Homo sapiens_hsa041140.89678968
91Amphetamine addiction_Homo sapiens_hsa050310.89564897
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88682424
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88120232
94Tight junction_Homo sapiens_hsa045300.87682919
95Cholinergic synapse_Homo sapiens_hsa047250.86869972
96* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86105046
97Salivary secretion_Homo sapiens_hsa049700.85508430
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85042875
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84734311
100Acute myeloid leukemia_Homo sapiens_hsa052210.84204548
101Influenza A_Homo sapiens_hsa051640.84088996
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83805395
103cAMP signaling pathway_Homo sapiens_hsa040240.83207833
104Bladder cancer_Homo sapiens_hsa052190.83085291
105Morphine addiction_Homo sapiens_hsa050320.82271649
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.80423061
107Non-homologous end-joining_Homo sapiens_hsa034500.80254087
108Nicotine addiction_Homo sapiens_hsa050330.78393354
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78145881
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.77997685
111Platelet activation_Homo sapiens_hsa046110.77656062
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.77505800
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76215172
114Hepatitis C_Homo sapiens_hsa051600.74779064
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72645837
116GABAergic synapse_Homo sapiens_hsa047270.72106832
117Pyrimidine metabolism_Homo sapiens_hsa002400.70574933
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70023631
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69508910
120Prolactin signaling pathway_Homo sapiens_hsa049170.69400292
121Cell cycle_Homo sapiens_hsa041100.68903341
122FoxO signaling pathway_Homo sapiens_hsa040680.68827878
123Amoebiasis_Homo sapiens_hsa051460.68240206
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68148024
125Measles_Homo sapiens_hsa051620.68086513
126AMPK signaling pathway_Homo sapiens_hsa041520.64908921
127Homologous recombination_Homo sapiens_hsa034400.64815827
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64713605
129Insulin signaling pathway_Homo sapiens_hsa049100.64686184
130Ras signaling pathway_Homo sapiens_hsa040140.64239383
131Primary immunodeficiency_Homo sapiens_hsa053400.62640755
132HIF-1 signaling pathway_Homo sapiens_hsa040660.58560226
133Shigellosis_Homo sapiens_hsa051310.58229011
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53794889
135Inositol phosphate metabolism_Homo sapiens_hsa005620.53396081
136Sulfur relay system_Homo sapiens_hsa041220.53142670
137Ribosome_Homo sapiens_hsa030100.51947576
138TNF signaling pathway_Homo sapiens_hsa046680.51378278
139Melanoma_Homo sapiens_hsa052180.51167170
140Fanconi anemia pathway_Homo sapiens_hsa034600.50539488
141Toxoplasmosis_Homo sapiens_hsa051450.48317696
142Carbon metabolism_Homo sapiens_hsa012000.46672643

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