FUT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)5.33576702
2behavioral response to nicotine (GO:0035095)5.28855679
3desmosome organization (GO:0002934)5.02229352
4establishment of skin barrier (GO:0061436)4.79466873
5keratinocyte development (GO:0003334)4.52647854
6regulation of water loss via skin (GO:0033561)4.34012623
7DNA deamination (GO:0045006)4.26750271
8polyketide metabolic process (GO:0030638)4.18761665
9doxorubicin metabolic process (GO:0044598)4.18761665
10daunorubicin metabolic process (GO:0044597)4.18761665
11regulation of dendritic cell antigen processing and presentation (GO:0002604)4.16578172
12superoxide anion generation (GO:0042554)3.98923000
13regulation of phospholipase A2 activity (GO:0032429)3.83785191
14positive regulation of antigen processing and presentation (GO:0002579)3.83454178
15response to pheromone (GO:0019236)3.71217309
16exocrine pancreas development (GO:0031017)3.62514086
17negative regulation of telomere maintenance (GO:0032205)3.62234558
18negative regulation of keratinocyte proliferation (GO:0010839)3.58127466
19positive regulation of T-helper 1 type immune response (GO:0002827)3.55931154
20regulation of antigen processing and presentation (GO:0002577)3.55094555
21proteasome assembly (GO:0043248)3.54610695
22water-soluble vitamin biosynthetic process (GO:0042364)3.52981372
23positive regulation of Cdc42 GTPase activity (GO:0043089)3.49550965
24sphingoid metabolic process (GO:0046519)3.49464751
25dendritic cell chemotaxis (GO:0002407)3.49385972
26antigen processing and presentation of endogenous antigen (GO:0019883)3.49124748
27regulation of mesoderm development (GO:2000380)3.48050486
28regulation of interleukin-8 secretion (GO:2000482)3.47915973
29multicellular organismal water homeostasis (GO:0050891)3.42663154
30cellular ketone body metabolic process (GO:0046950)3.39339722
31kynurenine metabolic process (GO:0070189)3.38281065
32regulation of glucokinase activity (GO:0033131)3.38155546
33regulation of hexokinase activity (GO:1903299)3.38155546
34positive regulation of interleukin-1 beta secretion (GO:0050718)3.32528023
35protein-cofactor linkage (GO:0018065)3.30036106
36ganglion development (GO:0061548)3.29841962
37protein complex biogenesis (GO:0070271)3.29179713
38sympathetic nervous system development (GO:0048485)3.27001405
39intestinal cholesterol absorption (GO:0030299)3.26405279
40indolalkylamine metabolic process (GO:0006586)3.22723556
41indole-containing compound catabolic process (GO:0042436)3.21751372
42indolalkylamine catabolic process (GO:0046218)3.21751372
43tryptophan catabolic process (GO:0006569)3.21751372
44respiratory chain complex IV assembly (GO:0008535)3.19424491
45water homeostasis (GO:0030104)3.19244225
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.16184736
47long-chain fatty acid biosynthetic process (GO:0042759)3.14886441
48dendritic cell migration (GO:0036336)3.14548426
49mesonephros development (GO:0001823)3.14544982
50mitochondrial respiratory chain complex assembly (GO:0033108)3.12463145
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.11624132
52NADH dehydrogenase complex assembly (GO:0010257)3.11624132
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11624132
54* fucose catabolic process (GO:0019317)3.09869432
55* L-fucose metabolic process (GO:0042354)3.09869432
56* L-fucose catabolic process (GO:0042355)3.09869432
57kidney morphogenesis (GO:0060993)3.09430626
58regulation of activation of Janus kinase activity (GO:0010533)3.08797540
59somite rostral/caudal axis specification (GO:0032525)3.07173165
60positive regulation of interleukin-1 secretion (GO:0050716)3.06042597
61detection of other organism (GO:0098543)3.05761342
62ketone body metabolic process (GO:1902224)3.04222025
63protein polyglutamylation (GO:0018095)3.00649972
64regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.00124959
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00102681
66positive regulation of interleukin-8 secretion (GO:2000484)2.98731631
67cytochrome complex assembly (GO:0017004)2.95413751
68ubiquinone biosynthetic process (GO:0006744)2.94948042
69platelet dense granule organization (GO:0060155)2.93125604
70regulation of chemokine secretion (GO:0090196)2.92458141
71regulation of interleukin-1 beta secretion (GO:0050706)2.90515905
72tryptophan metabolic process (GO:0006568)2.89611250
73detection of bacterium (GO:0016045)2.87931251
74energy homeostasis (GO:0097009)2.87680359
75positive regulation of cell fate commitment (GO:0010455)2.86708067
76DNA replication checkpoint (GO:0000076)2.86553686
77nephron epithelium morphogenesis (GO:0072088)2.86374899
78nephron tubule morphogenesis (GO:0072078)2.86374899
79ubiquinone metabolic process (GO:0006743)2.86357190
80regulation of timing of cell differentiation (GO:0048505)2.85652317
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85632623
82regulation of mitotic spindle checkpoint (GO:1903504)2.85632623
83regulation of cilium movement (GO:0003352)2.85520214
84adenosine metabolic process (GO:0046085)2.84581558
85regulation of nuclear cell cycle DNA replication (GO:0033262)2.84121932
86piRNA metabolic process (GO:0034587)2.83874170
87positive regulation of heat generation (GO:0031652)2.81515519
88eyelid development in camera-type eye (GO:0061029)2.81067057
89substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.80373132
90substrate-independent telencephalic tangential migration (GO:0021826)2.80373132
91purinergic nucleotide receptor signaling pathway (GO:0035590)2.80310258
92cornea development in camera-type eye (GO:0061303)2.78692329
93nonmotile primary cilium assembly (GO:0035058)2.78461654
94positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.77510234
95DNA double-strand break processing (GO:0000729)2.75066826
96signal peptide processing (GO:0006465)2.73501901
97negative regulation of translation, ncRNA-mediated (GO:0040033)2.73199325
98regulation of translation, ncRNA-mediated (GO:0045974)2.73199325
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73199325
100sulfation (GO:0051923)2.73030186
101detection of light stimulus involved in sensory perception (GO:0050962)2.72988634
102detection of light stimulus involved in visual perception (GO:0050908)2.72988634
103pharyngeal system development (GO:0060037)2.71773802
104synapsis (GO:0007129)2.71630305
105replication fork processing (GO:0031297)2.70115253
106positive regulation of interleukin-17 production (GO:0032740)2.70084010
107regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.70074275
108lipoxygenase pathway (GO:0019372)2.69163201
109regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.69017491
110regulation of cell proliferation involved in kidney development (GO:1901722)2.68984227
111sphingosine metabolic process (GO:0006670)2.68617819
112DNA methylation involved in gamete generation (GO:0043046)2.67960380
113reciprocal DNA recombination (GO:0035825)2.67870490
114reciprocal meiotic recombination (GO:0007131)2.67870490
115pseudouridine synthesis (GO:0001522)2.67199786
116membrane lipid catabolic process (GO:0046466)2.67002397
117pyrimidine dimer repair (GO:0006290)2.65810222
118keratinization (GO:0031424)2.65252627
119keratinocyte proliferation (GO:0043616)2.64002338
120L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62922871
121regulation of telomere maintenance (GO:0032204)2.62810078
122negative regulation of DNA-dependent DNA replication (GO:2000104)2.62445662
123regulation of T-helper 1 type immune response (GO:0002825)2.61662411
124mesenchymal cell differentiation involved in renal system development (GO:2001012)2.60494797
125mesenchymal cell differentiation involved in kidney development (GO:0072161)2.60494797
126gamma-aminobutyric acid transport (GO:0015812)2.60197195
127preassembly of GPI anchor in ER membrane (GO:0016254)2.59914980
128regulation of T-helper 1 cell differentiation (GO:0045625)2.59384618
129negative regulation of leukocyte chemotaxis (GO:0002689)2.58982683
130chemical homeostasis within a tissue (GO:0048875)2.58593269
131positive regulation of granulocyte chemotaxis (GO:0071624)2.57958921
132reflex (GO:0060004)2.57438479
133glucosamine-containing compound catabolic process (GO:1901072)2.57118352
134dopamine transport (GO:0015872)2.56229934
135tongue development (GO:0043586)2.55917650
136neuronal action potential (GO:0019228)2.55565936
137limb bud formation (GO:0060174)2.55446371
138sphingolipid catabolic process (GO:0030149)2.55099923
139cranial nerve morphogenesis (GO:0021602)2.54183259
140G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.53905116
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53375254
142tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53375254
143urinary tract smooth muscle contraction (GO:0014848)2.52919279
144positive regulation of interleukin-1 beta production (GO:0032731)2.52829860
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.52649358
146ceramide catabolic process (GO:0046514)2.52617369
147axoneme assembly (GO:0035082)2.51438483
148regulation of interleukin-1 secretion (GO:0050704)2.50551363
149positive regulation of cellular amide metabolic process (GO:0034250)2.50387297
150regulation of keratinocyte proliferation (GO:0010837)2.50162935
151diol metabolic process (GO:0034311)2.50000456
152epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49938083
153purine ribonucleotide transport (GO:0015868)2.49274405
154epithelial cell maturation (GO:0002070)2.49060550
155negative regulation of cell fate specification (GO:0009996)2.47963598
156indole-containing compound metabolic process (GO:0042430)2.47918084
157regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47600743
158single strand break repair (GO:0000012)2.47321431
159tRNA processing (GO:0008033)2.46301777
160antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45685263
161antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45685263
162epithelial cilium movement (GO:0003351)2.45319052
163dentate gyrus development (GO:0021542)2.45237336
164mannosylation (GO:0097502)2.45151361
165male meiosis I (GO:0007141)2.44667594
166rRNA catabolic process (GO:0016075)2.44271779
167keratinocyte differentiation (GO:0030216)2.44188923
168regulation of Cdc42 GTPase activity (GO:0043088)2.43949086
169intra-S DNA damage checkpoint (GO:0031573)2.43714309
170recombinational repair (GO:0000725)2.42541266
171positive regulation of interleukin-1 production (GO:0032732)2.42177125
172nucleotide transmembrane transport (GO:1901679)2.41827449
173double-strand break repair via homologous recombination (GO:0000724)2.41435946
174regulation of action potential (GO:0098900)2.41152204
175negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.40696629
176positive regulation of monocyte chemotaxis (GO:0090026)2.40675816
177cilium organization (GO:0044782)2.40450162
178signal transduction involved in regulation of gene expression (GO:0023019)2.40218918
179G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.39819523
180positive regulation of natural killer cell differentiation (GO:0032825)2.39784381
181myoblast migration (GO:0051451)2.39729501
182maturation of 5.8S rRNA (GO:0000460)2.39253114
183positive regulation of T cell mediated cytotoxicity (GO:0001916)2.38747263
184inner ear morphogenesis (GO:0042472)2.38162422
185digestion (GO:0007586)2.38141144
186protein K6-linked ubiquitination (GO:0085020)2.37770609
187primary amino compound metabolic process (GO:1901160)2.37602491
188regulation of development, heterochronic (GO:0040034)2.37550295
189exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36744988
190nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.34950445
191multicellular organism reproduction (GO:0032504)2.33128764
192regulation of rhodopsin mediated signaling pathway (GO:0022400)2.32664050
193mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.31712151
194cilium morphogenesis (GO:0060271)2.30983938
195startle response (GO:0001964)2.30724548
196protein localization to cilium (GO:0061512)2.30450206
197cilium assembly (GO:0042384)2.30094400
198protein K11-linked deubiquitination (GO:0035871)2.29469038
199behavioral response to ethanol (GO:0048149)2.29294644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.31515606
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.29765041
3GBX2_23144817_ChIP-Seq_PC3_Human3.00302295
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68126506
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44889661
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37557646
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35461564
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.28605006
9FUS_26573619_Chip-Seq_HEK293_Human2.27647682
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26736997
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.24853424
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23059025
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22919699
14EWS_26573619_Chip-Seq_HEK293_Human2.21891796
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20915181
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19424546
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14356835
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.12018949
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09299389
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06645051
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.06186455
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.99929759
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.99686807
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.94959871
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.94735298
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.94233563
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.88443943
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85637815
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82830048
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81435825
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.78147440
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74156782
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73741146
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73432105
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72744728
36IRF1_19129219_ChIP-ChIP_H3396_Human1.72164704
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68437394
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.67822813
39MYC_18940864_ChIP-ChIP_HL60_Human1.65547099
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63257537
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.62930474
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62401577
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.61838685
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60496401
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60005394
46TP53_18474530_ChIP-ChIP_U2OS_Human1.59939566
47TP53_22573176_ChIP-Seq_HFKS_Human1.59787316
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57617761
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.56760887
50TAF15_26573619_Chip-Seq_HEK293_Human1.54627022
51VDR_22108803_ChIP-Seq_LS180_Human1.54262101
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53201053
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52418576
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50921723
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.50348016
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48733908
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48136643
58P300_19829295_ChIP-Seq_ESCs_Human1.47665588
59P53_22387025_ChIP-Seq_ESCs_Mouse1.46165070
60SUZ12_18555785_Chip-Seq_ESCs_Mouse1.45826060
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.45545904
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44981518
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.44899902
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44659743
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43463837
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.43463837
67RNF2_27304074_Chip-Seq_NSC_Mouse1.42752630
68ER_23166858_ChIP-Seq_MCF-7_Human1.42611899
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42034763
70CBP_20019798_ChIP-Seq_JUKART_Human1.41775499
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41775499
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40998602
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40998602
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39614059
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.38326129
76ELK1_19687146_ChIP-ChIP_HELA_Human1.38035104
77STAT3_23295773_ChIP-Seq_U87_Human1.37834340
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.37334850
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36781946
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.35486113
81EZH2_22144423_ChIP-Seq_EOC_Human1.35369436
82NMYC_18555785_Chip-Seq_ESCs_Mouse1.35010962
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34679397
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34384846
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.33506907
86OCT4_18555785_Chip-Seq_ESCs_Mouse1.33025891
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32427415
88* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32041461
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31268435
90RUNX1_27457419_Chip-Seq_LIVER_Mouse1.31056257
91HOXB7_26014856_ChIP-Seq_BT474_Human1.30749775
92NANOG_19829295_ChIP-Seq_ESCs_Human1.30663225
93SOX2_19829295_ChIP-Seq_ESCs_Human1.30663225
94DROSHA_22980978_ChIP-Seq_HELA_Human1.29840447
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28772451
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28549255
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28549255
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.28148601
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28143342
100GATA3_21878914_ChIP-Seq_MCF-7_Human1.28055370
101P300_18555785_Chip-Seq_ESCs_Mouse1.27222571
102SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26668737
103TCF4_23295773_ChIP-Seq_U87_Human1.26151307
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26027358
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.25946022
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25778393
107REST_21632747_ChIP-Seq_MESCs_Mouse1.25432446
108ZFX_18555785_Chip-Seq_ESCs_Mouse1.25091066
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24780546
110VDR_23849224_ChIP-Seq_CD4+_Human1.24510795
111IGF1R_20145208_ChIP-Seq_DFB_Human1.24462277
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22730386
113OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22606817
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21989022
115TCF4_22108803_ChIP-Seq_LS180_Human1.21760060
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21146538
117PU1_27457419_Chip-Seq_LIVER_Mouse1.21055931
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20504993
119AHR_22903824_ChIP-Seq_MCF-7_Human1.19977592
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17861605
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17453135
122ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17304015
123BP1_19119308_ChIP-ChIP_Hs578T_Human1.17243275
124POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16556966
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.16102103
126KLF4_18555785_Chip-Seq_ESCs_Mouse1.15955731
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15547589
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14382458
129AR_20517297_ChIP-Seq_VCAP_Human1.14211262
130MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14000922
131AR_21572438_ChIP-Seq_LNCaP_Human1.13429595
132ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13247815
133TAL1_26923725_Chip-Seq_HPCs_Mouse1.12878247
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.12611340
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12388035
136CTCF_18555785_Chip-Seq_ESCs_Mouse1.11970007
137TP53_16413492_ChIP-PET_HCT116_Human1.11799833
138SMAD3_21741376_ChIP-Seq_EPCs_Human1.11680876
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10779643
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10487570
141NCOR_22424771_ChIP-Seq_293T_Human1.09937428
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09892846
143KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09579533
144BCAT_22108803_ChIP-Seq_LS180_Human1.09482377
145AR_25329375_ChIP-Seq_VCAP_Human1.09414710
146SMAD4_21799915_ChIP-Seq_A2780_Human1.06635979
147ESR1_21235772_ChIP-Seq_MCF-7_Human1.06493450
148RUNX2_22187159_ChIP-Seq_PCA_Human1.06207525
149SRF_21415370_ChIP-Seq_HL-1_Mouse1.03672659
150JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98383811
151AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96721978
152CDX2_22108803_ChIP-Seq_LS180_Human0.96586936
153ETS1_20019798_ChIP-Seq_JURKAT_Human0.95476229
154* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94661977
155SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93267680
156TAF2_19829295_ChIP-Seq_ESCs_Human0.92869447
157ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92769434
158ETV1_20927104_ChIP-Seq_GIST48_Human0.92332506
159CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92332160
160* ERA_21632823_ChIP-Seq_H3396_Human0.91636568
161PHF8_20622853_ChIP-Seq_HELA_Human0.91348460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.06819077
2MP0001346_abnormal_lacrimal_gland4.06246008
3MP0002876_abnormal_thyroid_physiology3.66988010
4MP0008877_abnormal_DNA_methylation3.32161876
5MP0000566_synostosis2.90702733
6MP0001835_abnormal_antigen_presentation2.81137642
7MP0002277_abnormal_respiratory_mucosa2.80176626
8MP0008789_abnormal_olfactory_epithelium2.77428556
9MP0006292_abnormal_olfactory_placode2.65919961
10MP0004147_increased_porphyrin_level2.63951224
11MP0002796_impaired_skin_barrier2.59646426
12MP0005645_abnormal_hypothalamus_physiol2.58714347
13MP0004782_abnormal_surfactant_physiolog2.43812466
14MP0005394_taste/olfaction_phenotype2.28962501
15MP0005499_abnormal_olfactory_system2.28962501
16MP0005551_abnormal_eye_electrophysiolog2.26389594
17MP0003941_abnormal_skin_development2.20968084
18MP0000685_abnormal_immune_system2.18404228
19MP0005310_abnormal_salivary_gland2.11988590
20MP0006072_abnormal_retinal_apoptosis2.04153202
21MP0002098_abnormal_vibrissa_morphology1.96415976
22MP0001968_abnormal_touch/_nociception1.92350177
23MP0001873_stomach_inflammation1.92149791
24MP0000613_abnormal_salivary_gland1.91560398
25MP0002837_dystrophic_cardiac_calcinosis1.89552221
26MP0008058_abnormal_DNA_repair1.87769289
27MP0004133_heterotaxia1.85545475
28MP0009046_muscle_twitch1.84137623
29MP0002148_abnormal_hypersensitivity_rea1.80678307
30MP0000383_abnormal_hair_follicle1.80401717
31MP0002132_abnormal_respiratory_system1.79155958
32MP0009745_abnormal_behavioral_response1.79019752
33MP0005084_abnormal_gallbladder_morpholo1.76277589
34MP0008872_abnormal_physiological_respon1.75677262
35MP0003879_abnormal_hair_cell1.73353504
36MP0004885_abnormal_endolymph1.72048843
37MP0005253_abnormal_eye_physiology1.67486926
38MP0003283_abnormal_digestive_organ1.66632936
39MP0005451_abnormal_body_composition1.65879137
40MP0002938_white_spotting1.63171392
41MP0003011_delayed_dark_adaptation1.62852559
42MP0005501_abnormal_skin_physiology1.62557513
43MP0003718_maternal_effect1.60926310
44MP0003646_muscle_fatigue1.60854269
45MP0000579_abnormal_nail_morphology1.59236127
46MP0002102_abnormal_ear_morphology1.59056750
47MP0002928_abnormal_bile_duct1.58621935
48MP0004142_abnormal_muscle_tone1.57243640
49MP0003890_abnormal_embryonic-extraembry1.56338647
50MP0008004_abnormal_stomach_pH1.56196031
51MP0001188_hyperpigmentation1.56057025
52MP0009785_altered_susceptibility_to1.54229247
53MP0001529_abnormal_vocalization1.53298816
54MP0001485_abnormal_pinna_reflex1.53218754
55MP0002272_abnormal_nervous_system1.49541453
56MP0004381_abnormal_hair_follicle1.49390342
57MP0008875_abnormal_xenobiotic_pharmacok1.48766819
58MP0010678_abnormal_skin_adnexa1.48586927
59MP0002653_abnormal_ependyma_morphology1.45748781
60MP0006082_CNS_inflammation1.45448213
61MP0003880_abnormal_central_pattern1.44827803
62MP0000516_abnormal_urinary_system1.44388608
63MP0005367_renal/urinary_system_phenotyp1.44388608
64MP0010234_abnormal_vibrissa_follicle1.43898872
65MP0001790_abnormal_immune_system1.42649045
66MP0005387_immune_system_phenotype1.42649045
67MP0000569_abnormal_digit_pigmentation1.41580583
68MP0000427_abnormal_hair_cycle1.41228988
69MP0006276_abnormal_autonomic_nervous1.38102848
70MP0002638_abnormal_pupillary_reflex1.35366050
71MP0005220_abnormal_exocrine_pancreas1.34554528
72MP0005647_abnormal_sex_gland1.34121039
73MP0000681_abnormal_thyroid_gland1.33570927
74MP0005410_abnormal_fertilization1.32627000
75MP0001486_abnormal_startle_reflex1.31755416
76MP0005671_abnormal_response_to1.30503443
77MP0010386_abnormal_urinary_bladder1.30363565
78MP0003868_abnormal_feces_composition1.30203202
79MP0001984_abnormal_olfaction1.27879808
80MP0002249_abnormal_larynx_morphology1.27701755
81MP0002735_abnormal_chemical_nociception1.26216458
82MP0003763_abnormal_thymus_physiology1.24506111
83MP0001348_abnormal_lacrimal_gland1.23601520
84MP0005379_endocrine/exocrine_gland_phen1.23567179
85MP0002160_abnormal_reproductive_system1.22685507
86MP0004742_abnormal_vestibular_system1.22315875
87MP0000470_abnormal_stomach_morphology1.21591005
88MP0001501_abnormal_sleep_pattern1.21504559
89MP0003121_genomic_imprinting1.20966532
90MP0001666_abnormal_nutrient_absorption1.20470680
91MP0000372_irregular_coat_pigmentation1.20100825
92MP0004510_myositis1.19982124
93MP0003183_abnormal_peptide_metabolism1.19774730
94MP0008775_abnormal_heart_ventricle1.18579716
95MP0004043_abnormal_pH_regulation1.18538700
96MP0008995_early_reproductive_senescence1.17281792
97MP0003878_abnormal_ear_physiology1.17270385
98MP0005377_hearing/vestibular/ear_phenot1.17270385
99MP0004145_abnormal_muscle_electrophysio1.16747495
100MP0001986_abnormal_taste_sensitivity1.16746332
101MP0005389_reproductive_system_phenotype1.15090297
102MP0002733_abnormal_thermal_nociception1.14826012
103MP0001216_abnormal_epidermal_layer1.13931829
104MP0003119_abnormal_digestive_system1.12377943
105MP0005646_abnormal_pituitary_gland1.12041884
106MP0002572_abnormal_emotion/affect_behav1.11771015
107MP0000049_abnormal_middle_ear1.11459718
108MP0000678_abnormal_parathyroid_gland1.11416846
109MP0010771_integument_phenotype1.11200918
110MP0000026_abnormal_inner_ear1.11057491
111MP0009250_abnormal_appendicular_skeleto1.09979913
112MP0002060_abnormal_skin_morphology1.09810816
113MP0002557_abnormal_social/conspecific_i1.08518256
114MP0000762_abnormal_tongue_morphology1.08384415
115MP0003195_calcinosis1.07591396
116MP0004924_abnormal_behavior1.06935747
117MP0005386_behavior/neurological_phenoty1.06935747
118MP0003453_abnormal_keratinocyte_physiol1.06716725
119MP0005025_abnormal_response_to1.03436965
120MP0001800_abnormal_humoral_immune1.03079470
121MP0002064_seizures1.02896380
122MP0005248_abnormal_Harderian_gland1.02259495
123MP0002067_abnormal_sensory_capabilities1.00892318
124MP0001664_abnormal_digestion1.00703662
125MP0005000_abnormal_immune_tolerance1.00109383
126MP0003122_maternal_imprinting1.00077089
127MP0001919_abnormal_reproductive_system0.99830760
128MP0001970_abnormal_pain_threshold0.98292508
129MP0005195_abnormal_posterior_eye0.97509947
130MP0003693_abnormal_embryo_hatching0.95551559
131MP0001905_abnormal_dopamine_level0.95332625
132MP0002233_abnormal_nose_morphology0.95058361
133MP0003938_abnormal_ear_development0.93579374
134MP0003937_abnormal_limbs/digits/tail_de0.93052966
135MP0000647_abnormal_sebaceous_gland0.91466685
136MP0001929_abnormal_gametogenesis0.90720185
137* MP0003698_abnormal_male_reproductive0.88898690
138* MP0002693_abnormal_pancreas_physiology0.87399170
139MP0009764_decreased_sensitivity_to0.86245287
140MP0002751_abnormal_autonomic_nervous0.86233994
141MP0002752_abnormal_somatic_nervous0.85451288
142MP0002210_abnormal_sex_determination0.85152666
143MP0002736_abnormal_nociception_after0.84554841
144MP0002452_abnormal_antigen_presenting0.84088935
145MP0003136_yellow_coat_color0.83098291
146MP0002419_abnormal_innate_immunity0.82510257
147MP0002229_neurodegeneration0.81832888
148MP0001542_abnormal_bone_strength0.81096855
149MP0000230_abnormal_systemic_arterial0.80378619
150MP0002184_abnormal_innervation0.80316108
151MP0002163_abnormal_gland_morphology0.80017534
152MP0004215_abnormal_myocardial_fiber0.79772703
153MP0002734_abnormal_mechanical_nocicepti0.79089751
154MP0001663_abnormal_digestive_system0.78456830
155MP0002405_respiratory_system_inflammati0.78237931
156MP0003787_abnormal_imprinting0.78141979
157MP0005423_abnormal_somatic_nervous0.78017387
158MP0005636_abnormal_mineral_homeostasis0.77921063
159MP0003635_abnormal_synaptic_transmissio0.77194670
160MP0001944_abnormal_pancreas_morphology0.76977231
161MP0004134_abnormal_chest_morphology0.75913854
162MP0002138_abnormal_hepatobiliary_system0.75736148
163MP0002063_abnormal_learning/memory/cond0.75676102
164MP0001963_abnormal_hearing_physiology0.75247866
165MP0002723_abnormal_immune_serum0.75036657
166MP0008260_abnormal_autophagy0.73668886
167MP0000538_abnormal_urinary_bladder0.73006620
168MP0003724_increased_susceptibility_to0.71874629
169MP0001845_abnormal_inflammatory_respons0.71782864
170MP0000631_abnormal_neuroendocrine_gland0.71261821
171MP0009765_abnormal_xenobiotic_induced0.71076768
172MP0010155_abnormal_intestine_physiology0.69591357
173MP0002234_abnormal_pharynx_morphology0.69223516

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)5.04852629
2Lip pit (HP:0100267)4.82713248
3Type II lissencephaly (HP:0007260)3.90490497
4Pancreatic cysts (HP:0001737)3.80538646
5Birth length less than 3rd percentile (HP:0003561)3.72884946
6Congenital stationary night blindness (HP:0007642)3.72292205
7Molar tooth sign on MRI (HP:0002419)3.62014376
8Abnormality of midbrain morphology (HP:0002418)3.62014376
9True hermaphroditism (HP:0010459)3.49400926
10Pancreatic fibrosis (HP:0100732)3.45310442
11Aplasia cutis congenita (HP:0001057)3.38481420
12Aplasia/Hypoplasia of the spleen (HP:0010451)3.31758511
13Septo-optic dysplasia (HP:0100842)3.31487481
14Nephronophthisis (HP:0000090)3.20409800
15Recurrent cutaneous fungal infections (HP:0011370)3.17657736
16Chronic mucocutaneous candidiasis (HP:0002728)3.17657736
17Parakeratosis (HP:0001036)3.16241926
18Asplenia (HP:0001746)3.14313046
19Plantar hyperkeratosis (HP:0007556)3.13726379
20Keratoconjunctivitis (HP:0001096)3.11768301
21Right ventricular cardiomyopathy (HP:0011663)3.07102287
22Increased IgE level (HP:0003212)3.03705362
23Dry hair (HP:0011359)2.99647342
24Cerebellar dysplasia (HP:0007033)2.97235438
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.94643163
26Absent/shortened dynein arms (HP:0200106)2.94643163
27Eczematoid dermatitis (HP:0000976)2.94407519
28Conical tooth (HP:0000698)2.93123341
29Tubulointerstitial nephritis (HP:0001970)2.90813472
30Abnormality of the pons (HP:0007361)2.83695789
31Pendular nystagmus (HP:0012043)2.81316480
32Chronic hepatic failure (HP:0100626)2.80338424
33Upper limb muscle weakness (HP:0003484)2.78226955
34Prolonged neonatal jaundice (HP:0006579)2.77473602
35Abnormality of the renal medulla (HP:0100957)2.77322266
36Hypoplasia of the pons (HP:0012110)2.75908468
37Popliteal pterygium (HP:0009756)2.74687952
38Recurrent pneumonia (HP:0006532)2.73646686
39Large for gestational age (HP:0001520)2.70512400
40Renal cortical cysts (HP:0000803)2.70096292
41Agammaglobulinemia (HP:0004432)2.68397013
42Medial flaring of the eyebrow (HP:0010747)2.66900928
43Attenuation of retinal blood vessels (HP:0007843)2.65758901
44Optic neuritis (HP:0100653)2.60120449
45Retrobulbar optic neuritis (HP:0100654)2.60120449
46White forelock (HP:0002211)2.57479099
47Double outlet right ventricle (HP:0001719)2.54080374
48Congenital malformation of the right heart (HP:0011723)2.54080374
49Palmoplantar hyperkeratosis (HP:0000972)2.53285207
50Abnormality of incisor morphology (HP:0011063)2.48210693
51Abnormality of calcium-phosphate metabolism (HP:0100530)2.47925638
52Type 2 muscle fiber atrophy (HP:0003554)2.47059771
53Abnormality of the labia minora (HP:0012880)2.46855977
54Tubular atrophy (HP:0000092)2.44749955
55Abnormality of the renal collecting system (HP:0004742)2.43678536
56Reduced antithrombin III activity (HP:0001976)2.43379605
57Patchy hypopigmentation of hair (HP:0011365)2.43171557
58Palmar hyperkeratosis (HP:0010765)2.42774207
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42322468
60Chromsome breakage (HP:0040012)2.42261544
61Lissencephaly (HP:0001339)2.39863550
62Amelogenesis imperfecta (HP:0000705)2.38492822
63Congenital, generalized hypertrichosis (HP:0004540)2.37774355
64Xerostomia (HP:0000217)2.37526940
65Abnormal rod and cone electroretinograms (HP:0008323)2.37361232
66Abnormal drinking behavior (HP:0030082)2.37222930
67Polydipsia (HP:0001959)2.37222930
68Optic nerve hypoplasia (HP:0000609)2.36884902
69Abolished electroretinogram (ERG) (HP:0000550)2.36548535
70Hypotrichosis (HP:0001006)2.35365423
71Abnormal ciliary motility (HP:0012262)2.35160452
72Acute necrotizing encephalopathy (HP:0006965)2.34360920
73Ectropion (HP:0000656)2.33247242
74Natal tooth (HP:0000695)2.31762597
75Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.31670323
76Chronic sinusitis (HP:0011109)2.30299388
77Sclerocornea (HP:0000647)2.30205840
78Congenital ichthyosiform erythroderma (HP:0007431)2.28853063
79Gaze-evoked nystagmus (HP:0000640)2.25700437
80Type I diabetes mellitus (HP:0100651)2.24466971
81Abnormality of the neuromuscular junction (HP:0003398)2.22790632
82Fatigable weakness (HP:0003473)2.22790632
83Concave nail (HP:0001598)2.22698631
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20859287
85Abnormality of alanine metabolism (HP:0010916)2.20859287
86Hyperalaninemia (HP:0003348)2.20859287
87Patellar aplasia (HP:0006443)2.20675886
88Duplicated collecting system (HP:0000081)2.20469318
89Furrowed tongue (HP:0000221)2.19880637
90Cystic liver disease (HP:0006706)2.18706161
91Orchitis (HP:0100796)2.18022048
92Progressive macrocephaly (HP:0004481)2.17610714
93Acute encephalopathy (HP:0006846)2.17240399
94Absent septum pellucidum (HP:0001331)2.15137992
95Aplasia/Hypoplasia of the patella (HP:0006498)2.14562299
96Abnormality of the renal cortex (HP:0011035)2.13613001
97Hypohidrosis (HP:0000966)2.11398079
98Premature loss of primary teeth (HP:0006323)2.09954999
99Increased corneal curvature (HP:0100692)2.09120116
100Keratoconus (HP:0000563)2.09120116
101Increased CSF lactate (HP:0002490)2.07715967
102Corneal erosion (HP:0200020)2.07607291
103Hypothermia (HP:0002045)2.07599150
104B lymphocytopenia (HP:0010976)2.06779491
105Abnormality of B cell number (HP:0010975)2.06779491
106Mitochondrial inheritance (HP:0001427)2.06424501
107Anencephaly (HP:0002323)2.06174939
108Hypoplasia of the uterus (HP:0000013)2.04792890
109Ketoacidosis (HP:0001993)2.04198961
110Hypomagnesemia (HP:0002917)2.03923541
111Keratitis (HP:0000491)2.02406394
112Hypoplasia of dental enamel (HP:0006297)2.02156929
113Sparse scalp hair (HP:0002209)2.01726230
114Nasolacrimal duct obstruction (HP:0000579)2.01615185
115Gait imbalance (HP:0002141)2.01183668
116Severe visual impairment (HP:0001141)2.00569087
117Myositis (HP:0100614)2.00127237
118Hyperventilation (HP:0002883)2.00097728
119Abnormal respiratory motile cilium morphology (HP:0005938)1.99561385
120Abnormal respiratory epithelium morphology (HP:0012253)1.99561385
121Retinal dysplasia (HP:0007973)1.98754487
122Polyuria (HP:0000103)1.98533161
123Vascular calcification (HP:0004934)1.98376279
124Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.98298750
125Hyperinsulinemic hypoglycemia (HP:0000825)1.98127251
126Type I transferrin isoform profile (HP:0003642)1.97929602
127Alveolar cell carcinoma (HP:0006519)1.97912893
128Recurrent lower respiratory tract infections (HP:0002783)1.96147239
129Muscle fiber atrophy (HP:0100295)1.95649662
130Abnormality of the phalanges of the 5th finger (HP:0004213)1.95480929
131Abnormal mitochondria in muscle tissue (HP:0008316)1.95094117
132Decreased central vision (HP:0007663)1.94520006
133Stomach cancer (HP:0012126)1.94484006
134Weak cry (HP:0001612)1.93846030
135Congenital primary aphakia (HP:0007707)1.93513232
136Recurrent sinusitis (HP:0011108)1.92918313
137Aplasia/hypoplasia of the uterus (HP:0008684)1.92819788
138Short middle phalanx of the 5th finger (HP:0004220)1.92409183
139Erythema (HP:0010783)1.92217793
140Abnormal respiratory motile cilium physiology (HP:0012261)1.91664633
141Bony spicule pigmentary retinopathy (HP:0007737)1.90824932
142Gangrene (HP:0100758)1.90370731
143Inability to walk (HP:0002540)1.89607533
144Abnormality of DNA repair (HP:0003254)1.89234661
145Broad-based gait (HP:0002136)1.89211219
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88708177
147Thyroid-stimulating hormone excess (HP:0002925)1.88670610
148Methylmalonic acidemia (HP:0002912)1.88654018
149Recurrent skin infections (HP:0001581)1.88318637
150Aplasia/Hypoplasia of the tongue (HP:0010295)1.86702855
151Hyperphosphatemia (HP:0002905)1.86198509
152Lipid accumulation in hepatocytes (HP:0006561)1.85954159
153Abnormality of the septum pellucidum (HP:0007375)1.85495933
154Ectopic kidney (HP:0000086)1.85348314
155Chronic otitis media (HP:0000389)1.85278216
156Osteomalacia (HP:0002749)1.85096746
157Severe muscular hypotonia (HP:0006829)1.83548429
158Male pseudohermaphroditism (HP:0000037)1.83292620
159Absent thumb (HP:0009777)1.83201384
160Nephrogenic diabetes insipidus (HP:0009806)1.82666188
161Abnormality of cochlea (HP:0000375)1.82413464
162Increased hepatocellular lipid droplets (HP:0006565)1.82129625
163Ketosis (HP:0001946)1.82127153
164Chorioretinal atrophy (HP:0000533)1.81948259
165Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80162321
166Fragile nails (HP:0001808)1.79318283
167Aplasia/Hypoplasia of the uvula (HP:0010293)1.78473490
168Abnormality of nail color (HP:0100643)1.77044956
169Congenital hepatic fibrosis (HP:0002612)1.76579929
170Hepatic necrosis (HP:0002605)1.73354412
1713-Methylglutaconic aciduria (HP:0003535)1.72951902
172Dandy-Walker malformation (HP:0001305)1.71347030
173Abnormality of macular pigmentation (HP:0008002)1.70978857
174Genital tract atresia (HP:0001827)1.70692236
175Optic disc pallor (HP:0000543)1.70636688
176Progressive cerebellar ataxia (HP:0002073)1.70449760
177Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69913581
178Postaxial foot polydactyly (HP:0001830)1.69880627
179Decreased circulating renin level (HP:0003351)1.69010941
180Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68568580
181Bilateral microphthalmos (HP:0007633)1.67956788
182Occipital encephalocele (HP:0002085)1.67331200
183Tachypnea (HP:0002789)1.67124401
184Anterior segment dysgenesis (HP:0007700)1.66871951
185Abnormal biliary tract physiology (HP:0012439)1.66506039
186Bile duct proliferation (HP:0001408)1.66506039
187Vaginal atresia (HP:0000148)1.65633293
188Hepatocellular necrosis (HP:0001404)1.65432000
189Abnormal number of erythroid precursors (HP:0012131)1.64699014
190Hemiparesis (HP:0001269)1.62957750
191Pachygyria (HP:0001302)1.62219685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.24955297
2MAP3K144.16865557
3TLK14.03861722
4BLK3.82522211
5CASK2.84989240
6IRAK32.81692266
7IRAK42.69858812
8WNK32.57221737
9ACVR1B2.30185386
10NME22.29079219
11STK162.24940187
12PNCK2.15067352
13MAP3K132.11328841
14MKNK22.08968151
15WNK41.96504589
16FRK1.92120170
17ERBB31.91378228
18NLK1.89107964
19IRAK11.87260195
20OXSR11.86626359
21TSSK61.80567559
22EIF2AK21.75429575
23MAP4K21.71334297
24EPHA31.69387034
25ADRBK21.66266253
26GRK11.65072583
27BMPR21.62035936
28VRK11.57224739
29TIE11.55386639
30LMTK21.45071370
31SIK31.44947786
32TEC1.44712304
33NEK61.43508444
34IKBKB1.40058098
35PLK31.40005157
36TRPM71.38241897
37BRD41.36577566
38IKBKE1.33190023
39TRIM281.30808668
40STK391.30140448
41MKNK11.28257177
42CDK31.25592020
43WEE11.23784890
44MST41.21684167
45CHUK1.18131493
46PRPF4B1.17228335
47TYK21.16029897
48MUSK1.13480120
49GRK71.12277491
50PRKCG1.09962065
51ZAK1.08900281
52MAP3K41.08607876
53TGFBR11.07762733
54MAPK131.06070922
55ADRBK11.05059157
56DAPK21.04734632
57INSRR1.04166348
58NTRK31.03551154
59FGFR21.03104372
60PAK31.01273718
61DYRK1A1.00608268
62BCR1.00529319
63PLK20.98734145
64EPHA20.97363122
65PHKG10.97276582
66PHKG20.97276582
67SRPK10.92824683
68PLK40.88999077
69MAPKAPK50.87192605
70YES10.87159355
71CAMK1D0.85073010
72BRSK20.83373920
73TXK0.82104175
74JAK10.80640974
75CDK80.78817057
76TGFBR20.78496554
77TBK10.78425027
78STK38L0.78379745
79CSNK1G20.78338332
80STK30.77098703
81MAPK150.75975105
82CSNK1G10.74459883
83EPHB20.74277801
84STK240.74122652
85MAP2K70.73617599
86PRKG20.73556153
87TNK20.72826725
88CAMKK20.71910645
89BTK0.69887286
90PKN10.69429527
91CSNK1G30.66914223
92FER0.66823214
93IRAK20.64434919
94EIF2AK30.63282466
95SGK20.61890682
96NUAK10.60785114
97GRK50.60257665
98CAMK1G0.59034658
99PRKCE0.58287298
100PASK0.58096033
101PIM20.57376685
102PINK10.57274709
103TAF10.57013554
104MAP2K20.55040913
105CDK190.53419027
106EPHB10.53078819
107MST1R0.52057473
108PIK3CG0.51100807
109PLK10.50089896
110BUB10.49693122
111STK110.49242858
112PTK60.48950465
113PTK2B0.48812961
114BCKDK0.48345345
115CSNK1A1L0.48234043
116DYRK20.46801498
117SYK0.46746107
118MARK10.46628730
119MAP3K70.45674377
120SGK4940.44788524
121SGK2230.44788524
122NME10.43358126
123PIK3CA0.43225570
124RPS6KA50.42719663
125CAMK2A0.42103631
126MAP3K30.41658816
127MAPKAPK30.41202116
128RIPK40.40857582
129CLK10.40447976
130CDC70.39002558
131MAPK70.38752151
132LYN0.38193620
133PBK0.37573328
134PRKCI0.37519253
135ATM0.37223831
136MAP2K60.36189600
137BMPR1B0.35473423
138JAK30.34804621
139CSNK1D0.34580762
140PRKAA10.34156684
141ATR0.33948513
142VRK20.33774133
143ERN10.33061700
144CSNK1A10.31946768
145PRKG10.31842819
146MINK10.31230851
147CAMK10.30338923
148PRKACA0.29388204
149PRKCA0.29185552
150MAPK30.29158195
151CHEK20.29151308
152PRKAA20.28419002
153TAOK30.28352630
154MAPK120.28170356
155PRKCQ0.27899025
156CSNK2A10.25890071

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.02260249
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.82506387
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.77145867
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.55282103
5Butanoate metabolism_Homo sapiens_hsa006502.52137439
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42263562
7Selenocompound metabolism_Homo sapiens_hsa004502.38654795
8Sphingolipid metabolism_Homo sapiens_hsa006002.33064895
9Oxidative phosphorylation_Homo sapiens_hsa001902.31800299
10Pancreatic secretion_Homo sapiens_hsa049722.24417411
11Homologous recombination_Homo sapiens_hsa034402.24205428
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.17684680
13Histidine metabolism_Homo sapiens_hsa003402.05996866
14Nitrogen metabolism_Homo sapiens_hsa009102.04467243
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.01516741
16Fanconi anemia pathway_Homo sapiens_hsa034602.00900185
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00690411
18Caffeine metabolism_Homo sapiens_hsa002321.97455691
19Vitamin B6 metabolism_Homo sapiens_hsa007501.96061241
20RNA polymerase_Homo sapiens_hsa030201.93143249
21Arachidonic acid metabolism_Homo sapiens_hsa005901.92844031
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90534672
23Tryptophan metabolism_Homo sapiens_hsa003801.89960354
24Asthma_Homo sapiens_hsa053101.88162328
25Primary immunodeficiency_Homo sapiens_hsa053401.83242552
26Basal transcription factors_Homo sapiens_hsa030221.76905978
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.74663635
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73388810
29Parkinsons disease_Homo sapiens_hsa050121.73189196
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69398317
31Linoleic acid metabolism_Homo sapiens_hsa005911.66235733
32One carbon pool by folate_Homo sapiens_hsa006701.66034408
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65282813
34Rheumatoid arthritis_Homo sapiens_hsa053231.63192217
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61702545
36Steroid biosynthesis_Homo sapiens_hsa001001.61457660
37Allograft rejection_Homo sapiens_hsa053301.59160744
38Propanoate metabolism_Homo sapiens_hsa006401.57306677
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54428518
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54379539
41Chemical carcinogenesis_Homo sapiens_hsa052041.50709888
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.50599678
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50357990
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46684431
45Ether lipid metabolism_Homo sapiens_hsa005651.42370734
46Retinol metabolism_Homo sapiens_hsa008301.40536347
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40094729
48Protein digestion and absorption_Homo sapiens_hsa049741.39918346
49RNA degradation_Homo sapiens_hsa030181.39287501
50Autoimmune thyroid disease_Homo sapiens_hsa053201.31164585
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30122523
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27677544
53Vitamin digestion and absorption_Homo sapiens_hsa049771.20337275
54African trypanosomiasis_Homo sapiens_hsa051431.17814975
55Huntingtons disease_Homo sapiens_hsa050161.17069871
56Fatty acid elongation_Homo sapiens_hsa000621.17013402
57ABC transporters_Homo sapiens_hsa020101.14531388
58Phototransduction_Homo sapiens_hsa047441.13389514
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13096201
60Taste transduction_Homo sapiens_hsa047421.12446760
61Nicotine addiction_Homo sapiens_hsa050331.11963701
62Phenylalanine metabolism_Homo sapiens_hsa003601.11153860
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09126893
64Peroxisome_Homo sapiens_hsa041461.06621699
65Maturity onset diabetes of the young_Homo sapiens_hsa049501.06495064
66Other glycan degradation_Homo sapiens_hsa005111.05990754
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05832171
68Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05530566
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05216338
70Malaria_Homo sapiens_hsa051441.05153836
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05086800
72Alzheimers disease_Homo sapiens_hsa050101.04832010
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04398565
74Serotonergic synapse_Homo sapiens_hsa047261.04199289
75Proteasome_Homo sapiens_hsa030501.03289542
76Primary bile acid biosynthesis_Homo sapiens_hsa001201.03246677
77Legionellosis_Homo sapiens_hsa051341.02761702
78Olfactory transduction_Homo sapiens_hsa047401.02541043
79Basal cell carcinoma_Homo sapiens_hsa052171.01928221
80Leishmaniasis_Homo sapiens_hsa051401.01603793
81Folate biosynthesis_Homo sapiens_hsa007901.00580847
82Cardiac muscle contraction_Homo sapiens_hsa042601.00173458
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.99774194
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97739683
85Graft-versus-host disease_Homo sapiens_hsa053320.95227340
86Purine metabolism_Homo sapiens_hsa002300.93028024
87RNA transport_Homo sapiens_hsa030130.89888475
88Measles_Homo sapiens_hsa051620.89237667
89Sulfur metabolism_Homo sapiens_hsa009200.84490175
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.82571913
91GABAergic synapse_Homo sapiens_hsa047270.80137283
92Influenza A_Homo sapiens_hsa051640.78469224
93Hematopoietic cell lineage_Homo sapiens_hsa046400.78228747
94Ribosome_Homo sapiens_hsa030100.77683688
95TNF signaling pathway_Homo sapiens_hsa046680.77036356
96* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75482396
97Calcium signaling pathway_Homo sapiens_hsa040200.75418985
98Pyrimidine metabolism_Homo sapiens_hsa002400.73644339
99* Metabolic pathways_Homo sapiens_hsa011000.73461457
100Arginine and proline metabolism_Homo sapiens_hsa003300.68760983
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68646246
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68580075
103Nucleotide excision repair_Homo sapiens_hsa034200.68249447
104Mineral absorption_Homo sapiens_hsa049780.66187929
105beta-Alanine metabolism_Homo sapiens_hsa004100.64231617
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63286728
107Mismatch repair_Homo sapiens_hsa034300.62468229
108Tuberculosis_Homo sapiens_hsa051520.61528094
109Morphine addiction_Homo sapiens_hsa050320.61296349
110Vibrio cholerae infection_Homo sapiens_hsa051100.60812033
111Osteoclast differentiation_Homo sapiens_hsa043800.59764672
112Phagosome_Homo sapiens_hsa041450.59604308
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58912364
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58905186
115Fatty acid metabolism_Homo sapiens_hsa012120.58338571
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56876969
117p53 signaling pathway_Homo sapiens_hsa041150.56552450
118Melanoma_Homo sapiens_hsa052180.55589684
119Chemokine signaling pathway_Homo sapiens_hsa040620.55394970
120Fatty acid biosynthesis_Homo sapiens_hsa000610.53347531
121Herpes simplex infection_Homo sapiens_hsa051680.52886999
122Hepatitis C_Homo sapiens_hsa051600.52334780
123Glutamatergic synapse_Homo sapiens_hsa047240.51787994
124Salivary secretion_Homo sapiens_hsa049700.50524396
125Fat digestion and absorption_Homo sapiens_hsa049750.49372211
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48109211
127Pertussis_Homo sapiens_hsa051330.46939613
128Glycerolipid metabolism_Homo sapiens_hsa005610.46483123
129Glutathione metabolism_Homo sapiens_hsa004800.46224015
130Ras signaling pathway_Homo sapiens_hsa040140.45803656
131* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45232564
132Insulin secretion_Homo sapiens_hsa049110.42833808
133Non-homologous end-joining_Homo sapiens_hsa034500.42293498
134Amphetamine addiction_Homo sapiens_hsa050310.41421108
135Pyruvate metabolism_Homo sapiens_hsa006200.40554027
136Ovarian steroidogenesis_Homo sapiens_hsa049130.40433273
137Tyrosine metabolism_Homo sapiens_hsa003500.40373153
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39651277
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38076062
140Starch and sucrose metabolism_Homo sapiens_hsa005000.37443332
141Regulation of autophagy_Homo sapiens_hsa041400.37141039
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36342593
143Dopaminergic synapse_Homo sapiens_hsa047280.35326972
144Circadian entrainment_Homo sapiens_hsa047130.34970728
145Fatty acid degradation_Homo sapiens_hsa000710.34746061
146Collecting duct acid secretion_Homo sapiens_hsa049660.34718648
147Toxoplasmosis_Homo sapiens_hsa051450.34272761
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31143361
149Dorso-ventral axis formation_Homo sapiens_hsa043200.29886661
150Staphylococcus aureus infection_Homo sapiens_hsa051500.28332716
151Circadian rhythm_Homo sapiens_hsa047100.28036485

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