FUT10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.43151144
2protein prenylation (GO:0018342)6.39221665
3prenylation (GO:0097354)6.39221665
4positive regulation of mitotic sister chromatid separation (GO:1901970)5.33875512
5positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.33875512
6positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.33875512
7DNA unwinding involved in DNA replication (GO:0006268)4.87513214
8non-recombinational repair (GO:0000726)4.24518559
9double-strand break repair via nonhomologous end joining (GO:0006303)4.24518559
10kidney mesenchyme development (GO:0072074)4.17155511
11acrosome assembly (GO:0001675)4.04907039
12replication fork processing (GO:0031297)3.89288542
13mitotic sister chromatid cohesion (GO:0007064)3.82784287
14positive regulation of chromosome segregation (GO:0051984)3.81209643
15mitotic chromosome condensation (GO:0007076)3.64753024
16DNA double-strand break processing (GO:0000729)3.61654498
17protein localization to kinetochore (GO:0034501)3.51484734
18cell proliferation involved in metanephros development (GO:0072203)3.48288883
19regulation of spindle organization (GO:0090224)3.45089614
20metanephric mesenchyme development (GO:0072075)3.43368582
21proteasome assembly (GO:0043248)3.38159042
22negative regulation of Ras GTPase activity (GO:0034261)3.35881014
23DNA replication-dependent nucleosome assembly (GO:0006335)3.34057940
24DNA replication-dependent nucleosome organization (GO:0034723)3.34057940
25chondrocyte proliferation (GO:0035988)3.33937391
26IMP biosynthetic process (GO:0006188)3.32734508
27recombinational repair (GO:0000725)3.30163656
28sister chromatid segregation (GO:0000819)3.30006714
29double-strand break repair via homologous recombination (GO:0000724)3.28901604
30negative regulation of DNA repair (GO:0045738)3.25401936
31G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.24478459
32attachment of spindle microtubules to kinetochore (GO:0008608)3.22659263
33DNA integration (GO:0015074)3.19537684
34telomere maintenance via recombination (GO:0000722)3.17783107
35neural tube formation (GO:0001841)3.17083193
36kinetochore organization (GO:0051383)3.16067145
37DNA strand elongation involved in DNA replication (GO:0006271)3.14082680
38mitotic spindle assembly checkpoint (GO:0007094)3.13692793
39outer ear morphogenesis (GO:0042473)3.13651277
40regulation of mitotic spindle organization (GO:0060236)3.12729617
41mitotic metaphase plate congression (GO:0007080)3.12365776
42mitochondrial RNA metabolic process (GO:0000959)3.12016264
43spindle assembly checkpoint (GO:0071173)3.07697013
44regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.07507086
45DNA replication initiation (GO:0006270)3.07257993
46mitotic sister chromatid segregation (GO:0000070)3.06228456
47IMP metabolic process (GO:0046040)3.05677711
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.03769624
49response to nitrosative stress (GO:0051409)3.03498664
50negative regulation of mitotic sister chromatid separation (GO:2000816)3.02545519
51negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02545519
52negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02545519
53negative regulation of sister chromatid segregation (GO:0033046)3.02545519
54mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.00917503
55branched-chain amino acid catabolic process (GO:0009083)3.00483127
56negative regulation of chromosome segregation (GO:0051985)2.98993272
57maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98773684
58regulation of meiosis I (GO:0060631)2.98497515
59methionine biosynthetic process (GO:0009086)2.97905320
60paraxial mesoderm development (GO:0048339)2.97828332
61definitive hemopoiesis (GO:0060216)2.97747374
62regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.97415431
63mitotic spindle checkpoint (GO:0071174)2.97167927
64meiotic chromosome segregation (GO:0045132)2.96674266
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95257155
66gonadal mesoderm development (GO:0007506)2.94899688
67histone-serine phosphorylation (GO:0035404)2.94670613
68negative regulation of DNA-dependent DNA replication (GO:2000104)2.94552521
69DNA strand elongation (GO:0022616)2.94477160
70bone trabecula formation (GO:0060346)2.93907491
71L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92615745
72spindle checkpoint (GO:0031577)2.92474637
73negative regulation of fibroblast apoptotic process (GO:2000270)2.91344709
74protein heterotrimerization (GO:0070208)2.90821988
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.90591141
76response to X-ray (GO:0010165)2.90214255
77detection of light stimulus involved in visual perception (GO:0050908)2.90097793
78detection of light stimulus involved in sensory perception (GO:0050962)2.90097793
79nuclear pore organization (GO:0006999)2.90014753
80regulation of hippo signaling (GO:0035330)2.89406326
81peptidyl-lysine dimethylation (GO:0018027)2.88993736
82histone H3-K9 methylation (GO:0051567)2.88983274
83preassembly of GPI anchor in ER membrane (GO:0016254)2.87343348
84collagen fibril organization (GO:0030199)2.85949619
85CENP-A containing nucleosome assembly (GO:0034080)2.84588580
86somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84323510
87somatic hypermutation of immunoglobulin genes (GO:0016446)2.84323510
88seminiferous tubule development (GO:0072520)2.82318972
89regulation of translation, ncRNA-mediated (GO:0045974)2.82153428
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82153428
91negative regulation of translation, ncRNA-mediated (GO:0040033)2.82153428
92cullin deneddylation (GO:0010388)2.81757590
93mesenchymal cell proliferation (GO:0010463)2.81016587
94hippo signaling (GO:0035329)2.80818889
95protein localization to chromosome, centromeric region (GO:0071459)2.80475386
96regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80427884
97synapsis (GO:0007129)2.79006643
98polarized epithelial cell differentiation (GO:0030859)2.78227069
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.78203314
100metaphase plate congression (GO:0051310)2.78137164
101methionine metabolic process (GO:0006555)2.77737879
102sequestering of extracellular ligand from receptor (GO:0035581)2.77265397
103photoreceptor cell maintenance (GO:0045494)2.77176283
104histone H2A acetylation (GO:0043968)2.76966546
105establishment of integrated proviral latency (GO:0075713)2.76554273
106oxidative demethylation (GO:0070989)2.76099212
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75298640
108branch elongation of an epithelium (GO:0060602)2.75225000
109DNA replication-independent nucleosome organization (GO:0034724)2.74747276
110DNA replication-independent nucleosome assembly (GO:0006336)2.74747276
111cell proliferation involved in kidney development (GO:0072111)2.74461250
112coenzyme A biosynthetic process (GO:0015937)2.73729694
113DNA duplex unwinding (GO:0032508)2.71749493
114regulation of chromosome segregation (GO:0051983)2.71506184
115nucleobase biosynthetic process (GO:0046112)2.71346149
116DNA geometric change (GO:0032392)2.71168604
117reciprocal meiotic recombination (GO:0007131)2.71079443
118reciprocal DNA recombination (GO:0035825)2.71079443
119tachykinin receptor signaling pathway (GO:0007217)2.70629287
120glucocorticoid receptor signaling pathway (GO:0042921)2.70274500
121respiratory chain complex IV assembly (GO:0008535)2.70192444
122protein polyglutamylation (GO:0018095)2.69883225
123vesicle fusion (GO:0006906)2.69874785
124planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69458329
125mitotic nuclear envelope disassembly (GO:0007077)2.68549703
126regulation of sister chromatid cohesion (GO:0007063)2.67383282
127regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66852853
128regulation of mitotic spindle checkpoint (GO:1903504)2.66852853
129telomere maintenance via semi-conservative replication (GO:0032201)2.66847927
130chromatin remodeling at centromere (GO:0031055)2.66762573
131protein deneddylation (GO:0000338)2.65966939
132telomere maintenance (GO:0000723)2.65517200
133translesion synthesis (GO:0019985)2.65226185
134auditory receptor cell stereocilium organization (GO:0060088)2.65183067
135cellular ketone body metabolic process (GO:0046950)2.65013165
136regulation of sister chromatid segregation (GO:0033045)2.64456077
137regulation of mitotic sister chromatid separation (GO:0010965)2.64456077
138regulation of mitotic sister chromatid segregation (GO:0033047)2.64456077
139negative regulation of mitosis (GO:0045839)2.64431047
140kinetochore assembly (GO:0051382)2.64044172
141response to pheromone (GO:0019236)2.63197133
142centrosome duplication (GO:0051298)2.61518973
143telomere organization (GO:0032200)2.61511223
144resolution of meiotic recombination intermediates (GO:0000712)2.60136931
145nuclear envelope disassembly (GO:0051081)2.60114787
146membrane disassembly (GO:0030397)2.60114787
147regulation of gene silencing by RNA (GO:0060966)2.59627208
148regulation of posttranscriptional gene silencing (GO:0060147)2.59627208
149regulation of gene silencing by miRNA (GO:0060964)2.59627208
150UDP-N-acetylglucosamine metabolic process (GO:0006047)2.59570793
151DNA demethylation (GO:0080111)2.57949604
152craniofacial suture morphogenesis (GO:0097094)2.57609570
153inner ear receptor stereocilium organization (GO:0060122)2.57585408
154nuclear pore complex assembly (GO:0051292)2.57571623
155protein localization to chromosome (GO:0034502)2.57379295
156mesenchyme development (GO:0060485)2.56378379
157regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56329509
158regulation of nuclear cell cycle DNA replication (GO:0033262)2.55438912
159regulation of cellular senescence (GO:2000772)2.54228060
160dermatan sulfate biosynthetic process (GO:0030208)2.53481420
161detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.52190415
162retinal cone cell development (GO:0046549)2.52145393
163establishment of chromosome localization (GO:0051303)2.52134735
164mesenchymal-epithelial cell signaling (GO:0060638)2.51927877
165mitotic recombination (GO:0006312)2.51908609
166nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51693154
167organ growth (GO:0035265)2.51645997
168sulfur amino acid biosynthetic process (GO:0000097)2.51108696
169DNA strand renaturation (GO:0000733)2.50695249
170histone exchange (GO:0043486)2.49805018
171DNA dealkylation (GO:0035510)2.49740040
172establishment of mitotic spindle localization (GO:0040001)2.48212142
173ketone body metabolic process (GO:1902224)2.47868843
174pattern specification involved in kidney development (GO:0061004)2.47818651
175regulation of centrosome duplication (GO:0010824)2.47793157
176mitotic cytokinesis (GO:0000281)2.47347018
177regulation of centrosome cycle (GO:0046605)2.47281087
178platelet dense granule organization (GO:0060155)2.46990988
179ncRNA 3-end processing (GO:0043628)2.46230476
180chromatin assembly or disassembly (GO:0006333)2.43271222
181DNA damage induced protein phosphorylation (GO:0006975)2.43260263
182negative regulation of chondrocyte differentiation (GO:0032331)2.41375777
183postreplication repair (GO:0006301)2.41314757
184regulation of non-canonical Wnt signaling pathway (GO:2000050)2.40620695
185positive regulation of SMAD protein import into nucleus (GO:0060391)2.40433054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.57255952
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.95990959
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.43738784
4RBPJ_22232070_ChIP-Seq_NCS_Mouse4.28347981
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82508608
6* MYC_18555785_ChIP-Seq_MESCs_Mouse3.46261038
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.41406972
8VDR_22108803_ChIP-Seq_LS180_Human3.25390389
9GBX2_23144817_ChIP-Seq_PC3_Human3.06931068
10ZNF274_21170338_ChIP-Seq_K562_Hela2.86593871
11AR_21909140_ChIP-Seq_LNCAP_Human2.83632990
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72281979
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.49198897
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43897589
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43243551
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.42178083
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.40929918
18TAF15_26573619_Chip-Seq_HEK293_Human2.32242875
19* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31601612
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31156870
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.29350918
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21265860
23* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19463618
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18613581
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17960423
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16131529
27XRN2_22483619_ChIP-Seq_HELA_Human2.08437341
28* P300_19829295_ChIP-Seq_ESCs_Human2.07541120
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.07219754
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06816690
31STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06680478
32EGR1_19374776_ChIP-ChIP_THP-1_Human2.06162234
33IGF1R_20145208_ChIP-Seq_DFB_Human2.04128561
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02779136
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99259794
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.97328916
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95115677
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.94078420
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92915056
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88138698
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87990450
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.86877150
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.79731138
44* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79698472
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79099982
46* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78918540
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77742557
48IRF1_19129219_ChIP-ChIP_H3396_Human1.73227999
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67364313
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66885536
51GATA1_22025678_ChIP-Seq_K562_Human1.63600078
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60632693
53BCAT_22108803_ChIP-Seq_LS180_Human1.60000291
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.58750160
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.58436200
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57239790
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55640841
58SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.55277060
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52409786
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52334281
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52222463
62TTF2_22483619_ChIP-Seq_HELA_Human1.51134001
63STAT3_23295773_ChIP-Seq_U87_Human1.50805960
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50386875
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.50003363
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49695426
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48965618
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48793973
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48207716
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47953828
71* SMAD4_21799915_ChIP-Seq_A2780_Human1.47093967
72CBP_20019798_ChIP-Seq_JUKART_Human1.45960229
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45960229
74ELK1_19687146_ChIP-ChIP_HELA_Human1.45410202
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44502700
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.44333038
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43604478
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.42912040
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39420715
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.39375348
81AR_21572438_ChIP-Seq_LNCaP_Human1.39130970
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38333377
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38111871
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37618761
85ER_23166858_ChIP-Seq_MCF-7_Human1.37084150
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34419476
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34097506
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33633974
89CLOCK_20551151_ChIP-Seq_293T_Human1.32614204
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32554641
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.32457130
92BRD4_25478319_ChIP-Seq_HGPS_Human1.32364475
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32159992
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30997292
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30972831
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30811836
97TCF4_23295773_ChIP-Seq_U87_Human1.30257757
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28759946
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28177705
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.27918632
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.26001918
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25065817
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24286260
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24286260
105CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23923125
106* TCF4_22108803_ChIP-Seq_LS180_Human1.23272168
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23076304
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22975802
109MYC_22102868_ChIP-Seq_BL_Human1.22765752
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21608219
111* FOXP3_21729870_ChIP-Seq_TREG_Human1.21248486
112GABP_17652178_ChIP-ChIP_JURKAT_Human1.20676613
113RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20504841
114CIITA_25753668_ChIP-Seq_RAJI_Human1.20256828
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19238122
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19222688
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17337035
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.16940746
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16617042
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15312278
121* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14126756
122MYC_18940864_ChIP-ChIP_HL60_Human1.13850437
123* NANOG_19829295_ChIP-Seq_ESCs_Human1.13216121
124* SOX2_19829295_ChIP-Seq_ESCs_Human1.13216121
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13175333
126* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13164383
127HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11886628
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11322943
129AR_25329375_ChIP-Seq_VCAP_Human1.10595901
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.10542482
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10461021
132TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10247711
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09919109
134* TP53_22573176_ChIP-Seq_HFKS_Human1.09246304
135TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08595594
136NANOG_18555785_Chip-Seq_ESCs_Mouse1.07848155
137TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07414157
138CDX2_22108803_ChIP-Seq_LS180_Human1.06653494
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06565955
140CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04787182
141EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04744802
142RUNX2_22187159_ChIP-Seq_PCA_Human1.04740925
143JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03611491
144PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03498482
145CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02968949
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01733306
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01704280
148GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01498255
149TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01422872
150GABP_19822575_ChIP-Seq_HepG2_Human1.01417363
151TP53_16413492_ChIP-PET_HCT116_Human1.01090598
152* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00816031
153CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00647933
154CHD1_26751641_Chip-Seq_LNCaP_Human1.00552738
155NANOG_21062744_ChIP-ChIP_HESCs_Human1.00391840
156TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99767604
157MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98596337
158E2F1_18555785_Chip-Seq_ESCs_Mouse0.98389998
159TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98333121
160EZH2_22144423_ChIP-Seq_EOC_Human0.98057133
161VDR_23849224_ChIP-Seq_CD4+_Human0.97645547
162TFEB_21752829_ChIP-Seq_HELA_Human0.97586536
163SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96605625
164CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95510793
165FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95405551
166TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94270048
167FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94061202
168ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93225496
169FUS_26573619_Chip-Seq_HEK293_Human0.93028515
170EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92625777
171POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91701852
172KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90954467
173KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90954467
174KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90954467
175* SOX17_20123909_ChIP-Seq_XEN_Mouse0.90723369
176EWS_26573619_Chip-Seq_HEK293_Human0.88047100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.50633168
2MP0000566_synostosis3.98555896
3MP0005503_abnormal_tendon_morphology3.33152994
4MP0010030_abnormal_orbit_morphology3.11563286
5MP0000372_irregular_coat_pigmentation2.97707378
6MP0003195_calcinosis2.85337485
7MP0006054_spinal_hemorrhage2.66280377
8MP0003136_yellow_coat_color2.65153051
9MP0003718_maternal_effect2.63137583
10MP0005623_abnormal_meninges_morphology2.59912165
11MP0003705_abnormal_hypodermis_morpholog2.54905690
12MP0003279_aneurysm2.48204901
13MP0003123_paternal_imprinting2.44473566
14MP0006292_abnormal_olfactory_placode2.42843290
15MP0000569_abnormal_digit_pigmentation2.37121871
16MP0008007_abnormal_cellular_replicative2.30041855
17MP0010094_abnormal_chromosome_stability2.19130419
18MP0009697_abnormal_copulation2.17289492
19MP0003111_abnormal_nucleus_morphology2.07086327
20MP0002938_white_spotting2.06644859
21MP0003942_abnormal_urinary_system2.03704284
22MP0006072_abnormal_retinal_apoptosis2.02134406
23MP0003077_abnormal_cell_cycle1.99911096
24MP0000383_abnormal_hair_follicle1.98319424
25MP0009250_abnormal_appendicular_skeleto1.98263726
26MP0005275_abnormal_skin_tensile1.96430640
27MP0005551_abnormal_eye_electrophysiolog1.94408477
28MP0002102_abnormal_ear_morphology1.91169414
29MP0000534_abnormal_ureter_morphology1.90950080
30MP0003937_abnormal_limbs/digits/tail_de1.88363524
31MP0003385_abnormal_body_wall1.86111940
32MP0004272_abnormal_basement_membrane1.85225500
33MP0005253_abnormal_eye_physiology1.79439391
34MP0000537_abnormal_urethra_morphology1.79182206
35MP0001293_anophthalmia1.73998986
36MP0002751_abnormal_autonomic_nervous1.73380596
37MP0003121_genomic_imprinting1.72881280
38MP0001299_abnormal_eye_distance/1.69035932
39MP0001958_emphysema1.68531361
40MP0004957_abnormal_blastocyst_morpholog1.68080856
41MP0004233_abnormal_muscle_weight1.67299687
42MP0000428_abnormal_craniofacial_morphol1.66462165
43MP0002932_abnormal_joint_morphology1.65838036
44MP0002249_abnormal_larynx_morphology1.64685282
45MP0010368_abnormal_lymphatic_system1.61326020
46MP0005508_abnormal_skeleton_morphology1.60786373
47MP0010352_gastrointestinal_tract_polyps1.60448635
48MP0003646_muscle_fatigue1.57345094
49MP0009053_abnormal_anal_canal1.56277999
50MP0000733_abnormal_muscle_development1.55486410
51MP0004147_increased_porphyrin_level1.54746122
52MP0000049_abnormal_middle_ear1.54443913
53MP0003122_maternal_imprinting1.51078711
54MP0006276_abnormal_autonomic_nervous1.48322339
55MP0001661_extended_life_span1.47293648
56MP0005395_other_phenotype1.46709732
57MP0009384_cardiac_valve_regurgitation1.46617918
58MP0008057_abnormal_DNA_replication1.45956928
59MP0004134_abnormal_chest_morphology1.45677150
60MP0008932_abnormal_embryonic_tissue1.43141871
61MP0003941_abnormal_skin_development1.42846483
62MP0003935_abnormal_craniofacial_develop1.42107247
63MP0002396_abnormal_hematopoietic_system1.38614897
64MP0001730_embryonic_growth_arrest1.36922886
65MP0010678_abnormal_skin_adnexa1.32540831
66MP0002085_abnormal_embryonic_tissue1.32337394
67MP0003890_abnormal_embryonic-extraembry1.31633879
68MP0000631_abnormal_neuroendocrine_gland1.31004283
69MP0000350_abnormal_cell_proliferation1.28454062
70MP0003115_abnormal_respiratory_system1.27877384
71MP0003755_abnormal_palate_morphology1.26925822
72MP0001485_abnormal_pinna_reflex1.26885822
73MP0002084_abnormal_developmental_patter1.26603406
74MP0003878_abnormal_ear_physiology1.25482528
75MP0005377_hearing/vestibular/ear_phenot1.25482528
76MP0001764_abnormal_homeostasis1.25256306
77MP0003693_abnormal_embryo_hatching1.24703422
78MP0005187_abnormal_penis_morphology1.24213383
79MP0008058_abnormal_DNA_repair1.24161526
80MP0003567_abnormal_fetal_cardiomyocyte1.21910216
81MP0008789_abnormal_olfactory_epithelium1.21040285
82MP0003283_abnormal_digestive_organ1.20868911
83MP0002092_abnormal_eye_morphology1.18266229
84MP0010307_abnormal_tumor_latency1.18256726
85MP0004808_abnormal_hematopoietic_stem1.16807458
86MP0001529_abnormal_vocalization1.16793776
87MP0004197_abnormal_fetal_growth/weight/1.16261712
88MP0002638_abnormal_pupillary_reflex1.15972590
89MP0002736_abnormal_nociception_after1.15641043
90MP0001879_abnormal_lymphatic_vessel1.15488146
91MP0001697_abnormal_embryo_size1.14787125
92MP0005023_abnormal_wound_healing1.13467975
93MP0001929_abnormal_gametogenesis1.12994195
94MP0002116_abnormal_craniofacial_bone1.12907912
95MP0002233_abnormal_nose_morphology1.12506050
96MP0000432_abnormal_head_morphology1.12166963
97MP0000358_abnormal_cell_content/1.10166442
98MP0002109_abnormal_limb_morphology1.10036658
99MP0004133_heterotaxia1.09679124
100MP0005174_abnormal_tail_pigmentation1.09069517
101MP0001324_abnormal_eye_pigmentation1.08142351
102MP0005408_hypopigmentation1.07850248
103MP0002210_abnormal_sex_determination1.06615982
104MP0005171_absent_coat_pigmentation1.06433708
105MP0008775_abnormal_heart_ventricle1.05772244
106MP0000516_abnormal_urinary_system1.05417431
107MP0005367_renal/urinary_system_phenotyp1.05417431
108MP0000647_abnormal_sebaceous_gland1.05008049
109MP0002114_abnormal_axial_skeleton1.04680270
110MP0002877_abnormal_melanocyte_morpholog1.04062890
111MP0000427_abnormal_hair_cycle1.03087652
112MP0001915_intracranial_hemorrhage1.03071751
113MP0005391_vision/eye_phenotype1.02367408
114MP0003786_premature_aging1.00241329
115MP0002090_abnormal_vision0.99769227
116MP0003950_abnormal_plasma_membrane0.99510757
117MP0001672_abnormal_embryogenesis/_devel0.99336211
118MP0005380_embryogenesis_phenotype0.99336211
119MP0001984_abnormal_olfaction0.97804712
120MP0005645_abnormal_hypothalamus_physiol0.97787610
121MP0002111_abnormal_tail_morphology0.97278620
122MP0000653_abnormal_sex_gland0.97274825
123MP0009046_muscle_twitch0.96572137
124MP0002876_abnormal_thyroid_physiology0.95838461
125MP0000767_abnormal_smooth_muscle0.95711501
126MP0005389_reproductive_system_phenotype0.95703264
127MP0002282_abnormal_trachea_morphology0.95212649
128MP0005220_abnormal_exocrine_pancreas0.94749881
129MP0005257_abnormal_intraocular_pressure0.93354211
130MP0003315_abnormal_perineum_morphology0.93070386
131MP0000163_abnormal_cartilage_morphology0.92614336
132MP0005410_abnormal_fertilization0.92162578
133MP0002925_abnormal_cardiovascular_devel0.92161069
134MP0002234_abnormal_pharynx_morphology0.92034481
135MP0002080_prenatal_lethality0.91598237
136MP0002697_abnormal_eye_size0.91042630
137MP0001919_abnormal_reproductive_system0.90777496
138MP0001664_abnormal_digestion0.89009909
139MP0003698_abnormal_male_reproductive0.88235026
140MP0002095_abnormal_skin_pigmentation0.87070587
141MP0003984_embryonic_growth_retardation0.86922812
142MP0002086_abnormal_extraembryonic_tissu0.86544175
143MP0008872_abnormal_physiological_respon0.85860762
144MP0002115_abnormal_skeleton_extremities0.85075708
145MP0002108_abnormal_muscle_morphology0.84454275
146MP0002177_abnormal_outer_ear0.84437641
147MP0002088_abnormal_embryonic_growth/wei0.83910025
148MP0001145_abnormal_male_reproductive0.83854734
149MP0005075_abnormal_melanosome_morpholog0.83490397
150MP0009278_abnormal_bone_marrow0.83332217
151MP0009703_decreased_birth_body0.82606786
152MP0002168_other_aberrant_phenotype0.82412331
153MP0001286_abnormal_eye_development0.82358858
154MP0002128_abnormal_blood_circulation0.81841226
155MP0005076_abnormal_cell_differentiation0.81598402
156MP0001119_abnormal_female_reproductive0.81225910
157MP0005646_abnormal_pituitary_gland0.80392296
158MP0002837_dystrophic_cardiac_calcinosis0.80284929
159MP0003943_abnormal_hepatobiliary_system0.80243639
160MP0002060_abnormal_skin_morphology0.80222254
161MP0009672_abnormal_birth_weight0.79979611
162MP0002113_abnormal_skeleton_development0.79058818
163MP0002184_abnormal_innervation0.78927491
164MP0001614_abnormal_blood_vessel0.77855777
165MP0001963_abnormal_hearing_physiology0.77054368
166MP0005195_abnormal_posterior_eye0.76201585
167MP0000015_abnormal_ear_pigmentation0.75784045
168MP0003861_abnormal_nervous_system0.74890961
169MP0008877_abnormal_DNA_methylation0.74872055
170MP0003252_abnormal_bile_duct0.73604010
171MP0004215_abnormal_myocardial_fiber0.72960086
172MP0001501_abnormal_sleep_pattern0.71600226
173MP0005332_abnormal_amino_acid0.70184027
174MP0001486_abnormal_startle_reflex0.67686533

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.58846443
2Short 4th metacarpal (HP:0010044)4.55484909
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.55484909
4Premature rupture of membranes (HP:0001788)4.49347226
5Shallow orbits (HP:0000586)3.93916340
6Duplicated collecting system (HP:0000081)3.62400127
7Abnormality of dentin (HP:0010299)3.53926535
8Soft skin (HP:0000977)3.33197224
9Ankle contracture (HP:0006466)3.31414799
10Abnormality of the renal collecting system (HP:0004742)3.28019077
11Abnormality of the 4th metacarpal (HP:0010012)3.26388503
12Pancreatic cysts (HP:0001737)3.22616399
13Abnormality of the labia minora (HP:0012880)3.19340408
14Broad metatarsal (HP:0001783)3.11727441
15Bladder diverticulum (HP:0000015)3.06183489
16Aortic dissection (HP:0002647)3.01917375
17Pancreatic fibrosis (HP:0100732)2.98299245
18Abnormality of midbrain morphology (HP:0002418)2.98231217
19Molar tooth sign on MRI (HP:0002419)2.98231217
20True hermaphroditism (HP:0010459)2.97945879
21Bifid tongue (HP:0010297)2.91705559
22Aortic aneurysm (HP:0004942)2.91366451
23Hypoplastic pelvis (HP:0008839)2.90432809
24Chromsome breakage (HP:0040012)2.86070781
25Hypoplasia of the fovea (HP:0007750)2.79846242
26Aplasia/Hypoplasia of the fovea (HP:0008060)2.79846242
27Renal duplication (HP:0000075)2.77834526
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77521124
29Adactyly (HP:0009776)2.76447553
30Large for gestational age (HP:0001520)2.71859127
31Bowel diverticulosis (HP:0005222)2.63115249
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.62931683
33Medial flaring of the eyebrow (HP:0010747)2.61076853
34Congenital stationary night blindness (HP:0007642)2.60450240
35Acute lymphatic leukemia (HP:0006721)2.58685358
36Clubbing of toes (HP:0100760)2.54524138
37Chronic hepatic failure (HP:0100626)2.53403361
38Central scotoma (HP:0000603)2.52472342
39Abnormality of the fovea (HP:0000493)2.52091393
40Nephronophthisis (HP:0000090)2.51920682
41Abnormality of chromosome stability (HP:0003220)2.50125320
42Abnormality of macular pigmentation (HP:0008002)2.49503791
43Abnormal auditory evoked potentials (HP:0006958)2.47891691
44Colon cancer (HP:0003003)2.47739027
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.46965646
46Attenuation of retinal blood vessels (HP:0007843)2.46616349
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.44922539
48Biconcave vertebral bodies (HP:0004586)2.44299528
49Long foot (HP:0001833)2.41145187
50Broad-based gait (HP:0002136)2.39842531
51Hyperglycinemia (HP:0002154)2.39506705
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.37885137
53Cerebral aneurysm (HP:0004944)2.37461813
54Abnormality of the renal cortex (HP:0011035)2.37307547
55Meckel diverticulum (HP:0002245)2.35199119
56Spinal cord lesions (HP:0100561)2.34043244
57Syringomyelia (HP:0003396)2.34043244
58Gaze-evoked nystagmus (HP:0000640)2.33251885
59Abnormality of the ileum (HP:0001549)2.32996114
60Abolished electroretinogram (ERG) (HP:0000550)2.31869210
61Abnormality of the renal medulla (HP:0100957)2.31845938
62Mesomelia (HP:0003027)2.28471726
63Genital tract atresia (HP:0001827)2.26713067
64Increased nuchal translucency (HP:0010880)2.25334789
65Albinism (HP:0001022)2.23792392
66Deviation of the hallux (HP:0010051)2.22421622
67Progressive inability to walk (HP:0002505)2.21154037
68Thin bony cortex (HP:0002753)2.19869409
69Wormian bones (HP:0002645)2.19525627
70Abnormality of the parietal bone (HP:0002696)2.19314644
71Abnormality of the calcaneus (HP:0008364)2.18366274
72Dilatation of the ascending aorta (HP:0005111)2.18333642
73Congenital primary aphakia (HP:0007707)2.17945000
74Vaginal atresia (HP:0000148)2.17066629
75Selective tooth agenesis (HP:0001592)2.15955243
76Bell-shaped thorax (HP:0001591)2.13337469
77Hallux valgus (HP:0001822)2.13161427
78Broad distal phalanx of finger (HP:0009836)2.13103630
79Decreased lacrimation (HP:0000633)2.12102950
80Coronal craniosynostosis (HP:0004440)2.10378552
81Intestinal atresia (HP:0011100)2.09224720
82Hypomagnesemia (HP:0002917)2.09099158
83Vascular tortuosity (HP:0004948)2.08982985
84Sloping forehead (HP:0000340)2.07047450
85Blue sclerae (HP:0000592)2.07023398
86Short nail (HP:0001799)2.06674257
87Abnormal protein glycosylation (HP:0012346)2.06338789
88Abnormal glycosylation (HP:0012345)2.06338789
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06338789
90Abnormal protein N-linked glycosylation (HP:0012347)2.06338789
91Broad long bones (HP:0005622)2.04974773
92Mitral regurgitation (HP:0001653)2.04597696
93Abnormality of the preputium (HP:0100587)2.04466328
94Abnormal lung lobation (HP:0002101)2.04294040
95Genu recurvatum (HP:0002816)2.02135340
96Flat cornea (HP:0007720)2.02061037
97Asymmetry of the thorax (HP:0001555)2.01551111
98Spinal rigidity (HP:0003306)2.01057773
99Broad toe (HP:0001837)2.00502327
100Deformed tarsal bones (HP:0008119)2.00094887
101Gait imbalance (HP:0002141)1.99806534
102Methylmalonic acidemia (HP:0002912)1.98986675
103Type I transferrin isoform profile (HP:0003642)1.96760097
104Arterial tortuosity (HP:0005116)1.96226051
105Astigmatism (HP:0000483)1.95825316
106Joint laxity (HP:0001388)1.95318036
107Broad phalanges of the hand (HP:0009768)1.94666237
108Medulloblastoma (HP:0002885)1.94415431
109Calcaneovalgus deformity (HP:0001848)1.94040335
110Embryonal renal neoplasm (HP:0011794)1.93512220
111Nephroblastoma (Wilms tumor) (HP:0002667)1.92346564
112Volvulus (HP:0002580)1.91014069
113Wrist flexion contracture (HP:0001239)1.90965588
114Oligodactyly (hands) (HP:0001180)1.90581310
115Neonatal short-limb short stature (HP:0008921)1.89866756
116Small intestinal stenosis (HP:0012848)1.89467615
117Duodenal stenosis (HP:0100867)1.89467615
118Ectopic kidney (HP:0000086)1.89047864
119Renal cortical cysts (HP:0000803)1.88433229
120Broad phalanx (HP:0006009)1.88223464
121Preaxial hand polydactyly (HP:0001177)1.88073727
122Nephrogenic diabetes insipidus (HP:0009806)1.88023897
123Tubulointerstitial nephritis (HP:0001970)1.87584751
124Bile duct proliferation (HP:0001408)1.85924130
125Abnormal biliary tract physiology (HP:0012439)1.85924130
126Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85837721
127Broad finger (HP:0001500)1.85329599
128Hypoplasia of the pons (HP:0012110)1.84689074
129Postaxial foot polydactyly (HP:0001830)1.83948954
130Abnormality of the peritoneum (HP:0002585)1.83304406
131Supernumerary spleens (HP:0009799)1.82907966
132Glioma (HP:0009733)1.82531386
133Cystic liver disease (HP:0006706)1.82177794
134Abnormality of the duodenum (HP:0002246)1.81990990
135Aortic regurgitation (HP:0001659)1.81854127
136Hyperglycinuria (HP:0003108)1.81654853
137Abnormality of the pons (HP:0007361)1.81203106
138Short tibia (HP:0005736)1.80058845
139Hypoplastic iliac wings (HP:0002866)1.80000336
140Chorioretinal coloboma (HP:0000567)1.79882984
141Congenital hepatic fibrosis (HP:0002612)1.79588073
142Severe muscular hypotonia (HP:0006829)1.79190328
143Missing ribs (HP:0000921)1.78693424
144Sclerocornea (HP:0000647)1.78392675
145Abnormality of methionine metabolism (HP:0010901)1.78351831
146Overriding aorta (HP:0002623)1.76562547
147Postaxial hand polydactyly (HP:0001162)1.76405605
148Mitral valve prolapse (HP:0001634)1.76340626
149Broad thumb (HP:0011304)1.76171124
150Overgrowth (HP:0001548)1.75669906
151Ependymoma (HP:0002888)1.73703549
152Widely spaced teeth (HP:0000687)1.73553624
153Buphthalmos (HP:0000557)1.73218408
154Microglossia (HP:0000171)1.72641597
155Abnormal number of incisors (HP:0011064)1.72340060
156Cutaneous melanoma (HP:0012056)1.71100396
157Hypothermia (HP:0002045)1.70793789
15811 pairs of ribs (HP:0000878)1.70244881
159Infantile muscular hypotonia (HP:0008947)1.70015892
160Methylmalonic aciduria (HP:0012120)1.70007418
161Trigonocephaly (HP:0000243)1.69760802
162Increased number of teeth (HP:0011069)1.69237845
163Abnormality of serine family amino acid metabolism (HP:0010894)1.69064439
164Abnormality of glycine metabolism (HP:0010895)1.69064439
165Oculomotor apraxia (HP:0000657)1.68757705
166Broad palm (HP:0001169)1.68375090
167Dry hair (HP:0011359)1.68022369
168Absent radius (HP:0003974)1.67982844
169Vertebral compression fractures (HP:0002953)1.67839726
170Small hand (HP:0200055)1.67417446
171Type 1 muscle fiber predominance (HP:0003803)1.66953820
172Peritonitis (HP:0002586)1.66101015
173Renovascular hypertension (HP:0100817)1.65721603
174Abnormality of the distal phalanx of the thumb (HP:0009617)1.65446501
175Neoplasm of the oral cavity (HP:0100649)1.65316421
176Fragile skin (HP:0001030)1.65191373
177Wide cranial sutures (HP:0010537)1.64486938
178Abnormality of the acetabulum (HP:0003170)1.63022582
179Broad hallux (HP:0010055)1.62595586
180Abnormal delivery (HP:0001787)1.60201413
181Atrophic scars (HP:0001075)1.59107639
182Broad ribs (HP:0000885)1.58629249
183Short hallux (HP:0010109)1.57272143
184Limb-girdle muscle weakness (HP:0003325)1.56803687
185Delayed cranial suture closure (HP:0000270)1.56792472
186Preaxial foot polydactyly (HP:0001841)1.55201464
187Subacute progressive viral hepatitis (HP:0006572)1.54644281
188Breech presentation (HP:0001623)1.53522141
189Deviation of the thumb (HP:0009603)1.52264897
190Atresia of the external auditory canal (HP:0000413)1.52056298
191Camptodactyly of toe (HP:0001836)1.51636104
192Spondylolisthesis (HP:0003302)1.51609397
193Prominent occiput (HP:0000269)1.50387033
194Midline defect of the nose (HP:0004122)1.49765100
195Abnormality of the fetal cardiovascular system (HP:0010948)1.49081446
196Abnormal umbilical cord blood vessels (HP:0011403)1.49081446
197Single umbilical artery (HP:0001195)1.49081446
198Decreased skull ossification (HP:0004331)1.48966081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.17030841
2CDC73.36480115
3PASK2.95082350
4EEF2K2.52746338
5LATS12.39699517
6BMPR1B2.27364462
7MKNK12.23269873
8NEK22.20487701
9MAP4K22.16327906
10PKN22.13655250
11ACVR1B2.13213545
12WEE12.08335333
13PDGFRA2.06934542
14LATS21.94013821
15DDR21.92819940
16TTN1.92156657
17WNK31.84428591
18TGFBR11.70997122
19EPHB21.69769401
20TNIK1.68976894
21EIF2AK31.67788467
22MAP2K31.64583923
23MST41.62045485
24LIMK11.60020554
25NUAK11.55443681
26TRIM281.54129990
27TSSK61.52741008
28MAP3K41.51278892
29NEK11.51277943
30FGFR11.51107119
31TAOK11.50415532
32TTK1.48936105
33PAK21.46103646
34ERBB31.43983288
35RPS6KA41.42250549
36PRKD31.41608482
37EIF2AK11.39769548
38NEK91.39743701
39PIK3CG1.39434830
40PLK31.38459812
41CDK81.38157952
42FLT31.36319729
43TESK21.27931300
44MAP3K101.26659378
45ATR1.25694446
46ILK1.22660278
47PLK11.22067157
48MKNK21.19270922
49MAP3K81.18505899
50AURKB1.14996191
51FGFR21.13618560
52BRSK21.09145908
53PAK41.09044348
54PINK11.07737403
55STK391.05083799
56GRK11.04576672
57RPS6KB21.04546360
58TRIB31.04000292
59CCNB11.03798267
60PLK21.03682189
61INSRR1.02588365
62ADRBK21.00827845
63SRPK10.97567583
64FER0.96179314
65OXSR10.95457098
66CDK60.93622526
67CDK70.91966000
68EPHA40.90882871
69CSNK1G10.90012791
70STK30.89854252
71MET0.89737259
72FRK0.88992340
73CHEK10.87796786
74PLK40.86997640
75TAF10.86781882
76ZAK0.86746466
77PDK20.84666032
78DYRK1A0.83896034
79DYRK30.83760714
80PBK0.83650386
81MAPK130.82005497
82PRPF4B0.81697465
83DMPK0.79706487
84STK38L0.78036563
85MELK0.75962169
86CDK40.74540854
87AKT30.74381269
88CLK10.74146164
89LRRK20.73908365
90BCKDK0.73698259
91MTOR0.73567786
92TLK10.72480685
93CHEK20.72379288
94ATM0.71512789
95MAP3K30.70748301
96PAK10.69342306
97MAP3K60.69182812
98CASK0.68955417
99CSNK1G30.68108425
100CAMK1D0.65525498
101CDK20.64702095
102TIE10.64607262
103TGFBR20.63880432
104CDK10.63679187
105TRPM70.61871385
106KSR10.61427216
107MUSK0.60908400
108PAK30.60746873
109PRKCE0.59650945
110VRK10.59602065
111ABL20.58904364
112ROCK20.58024919
113CSF1R0.57227240
114CDK180.57211206
115TAOK20.56998270
116VRK20.56497235
117MAP3K50.56012070
118CDK150.54781602
119JAK30.53353342
120STK100.52031039
121CSNK1G20.51114076
122WNK10.51094643
123CDK140.50153606
124MAP2K70.48582768
125MAP3K110.48071564
126PTK60.47866254
127AURKA0.47709972
128BCR0.47086290
129NLK0.46152711
130CDK11A0.45794188
131CSNK1A1L0.43934350
132ERBB20.43498717
133CAMK1G0.43491031
134ALK0.43395534
135TESK10.41076493
136BRD40.40842750
137MAPKAPK50.39905175
138CSNK1A10.39839921
139PRKDC0.39189151
140PNCK0.38876415
141ERBB40.38410286
142CDK190.37989643
143SIK10.37706539
144ADRBK10.37541565
145CDK30.35182970
146EIF2AK20.33252102
147BRSK10.32961161
148PTK2B0.31421845
149DYRK20.28606574
150NEK60.28038482
151MARK30.25078166
152RPS6KA50.23328268

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.95279971
2Cell cycle_Homo sapiens_hsa041103.42565576
3Mismatch repair_Homo sapiens_hsa034303.26623152
4Propanoate metabolism_Homo sapiens_hsa006403.04930414
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76876403
6Spliceosome_Homo sapiens_hsa030402.59058776
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.57697853
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54652506
9Butanoate metabolism_Homo sapiens_hsa006502.54215994
10Base excision repair_Homo sapiens_hsa034102.51301205
11RNA transport_Homo sapiens_hsa030132.17247642
12Basal cell carcinoma_Homo sapiens_hsa052172.16574887
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16177421
14Homologous recombination_Homo sapiens_hsa034402.16172521
15Nucleotide excision repair_Homo sapiens_hsa034202.12435675
16Proteasome_Homo sapiens_hsa030502.02530094
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90404117
18Non-homologous end-joining_Homo sapiens_hsa034501.82832112
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77661324
20MicroRNAs in cancer_Homo sapiens_hsa052061.75325570
21ECM-receptor interaction_Homo sapiens_hsa045121.72367896
22Hippo signaling pathway_Homo sapiens_hsa043901.71745889
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71528528
24One carbon pool by folate_Homo sapiens_hsa006701.69203440
25RNA degradation_Homo sapiens_hsa030181.67571787
26Fanconi anemia pathway_Homo sapiens_hsa034601.62699019
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.61357781
28TGF-beta signaling pathway_Homo sapiens_hsa043501.60343317
29Hedgehog signaling pathway_Homo sapiens_hsa043401.59605437
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59155773
31Tryptophan metabolism_Homo sapiens_hsa003801.59031004
32mRNA surveillance pathway_Homo sapiens_hsa030151.58561378
33p53 signaling pathway_Homo sapiens_hsa041151.55078942
34Fatty acid elongation_Homo sapiens_hsa000621.54587937
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.50835122
36Systemic lupus erythematosus_Homo sapiens_hsa053221.50365753
37Small cell lung cancer_Homo sapiens_hsa052221.47225368
38Oocyte meiosis_Homo sapiens_hsa041141.46077747
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.43557592
40RNA polymerase_Homo sapiens_hsa030201.43095404
41Focal adhesion_Homo sapiens_hsa045101.40785992
42Proteoglycans in cancer_Homo sapiens_hsa052051.38908432
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38660088
44HTLV-I infection_Homo sapiens_hsa051661.36697058
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30105575
46Fatty acid metabolism_Homo sapiens_hsa012121.28125687
47Steroid biosynthesis_Homo sapiens_hsa001001.27894021
48Pyrimidine metabolism_Homo sapiens_hsa002401.27587188
49Viral carcinogenesis_Homo sapiens_hsa052031.27116750
50Taste transduction_Homo sapiens_hsa047421.26633643
51Chronic myeloid leukemia_Homo sapiens_hsa052201.25943686
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24751877
53Colorectal cancer_Homo sapiens_hsa052101.24584761
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23607168
55Fatty acid degradation_Homo sapiens_hsa000711.20811512
56Basal transcription factors_Homo sapiens_hsa030221.18924782
57Nitrogen metabolism_Homo sapiens_hsa009101.17759149
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15837401
59Pyruvate metabolism_Homo sapiens_hsa006201.13889828
60Peroxisome_Homo sapiens_hsa041461.13777685
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11701408
62beta-Alanine metabolism_Homo sapiens_hsa004101.09585311
63Pancreatic cancer_Homo sapiens_hsa052121.07713628
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07088783
65Pathways in cancer_Homo sapiens_hsa052001.06935440
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05444721
67Purine metabolism_Homo sapiens_hsa002301.04365821
68Prostate cancer_Homo sapiens_hsa052151.03868866
69Alcoholism_Homo sapiens_hsa050341.02783872
70Thyroid cancer_Homo sapiens_hsa052161.01786035
71Adherens junction_Homo sapiens_hsa045201.00945137
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00092228
73Ribosome_Homo sapiens_hsa030100.99638698
74Wnt signaling pathway_Homo sapiens_hsa043100.99092370
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96878964
76Bladder cancer_Homo sapiens_hsa052190.95863688
77Notch signaling pathway_Homo sapiens_hsa043300.95633172
78Melanoma_Homo sapiens_hsa052180.95252300
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.93812611
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91943122
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91643787
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91205667
83Protein export_Homo sapiens_hsa030600.89337759
84N-Glycan biosynthesis_Homo sapiens_hsa005100.89003721
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88859251
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85141137
87Tight junction_Homo sapiens_hsa045300.84551154
88Caffeine metabolism_Homo sapiens_hsa002320.84267483
89Linoleic acid metabolism_Homo sapiens_hsa005910.83785952
90Ether lipid metabolism_Homo sapiens_hsa005650.83753866
91Dilated cardiomyopathy_Homo sapiens_hsa054140.78900215
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.78191107
93Glycerolipid metabolism_Homo sapiens_hsa005610.77894178
94Endometrial cancer_Homo sapiens_hsa052130.77730552
95Phototransduction_Homo sapiens_hsa047440.77653171
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76187916
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75179545
98Non-small cell lung cancer_Homo sapiens_hsa052230.75089586
99Glioma_Homo sapiens_hsa052140.74186728
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.73882548
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73579309
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73381508
103Glutathione metabolism_Homo sapiens_hsa004800.72222130
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71373242
105Metabolic pathways_Homo sapiens_hsa011000.71065805
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70917697
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69580022
108Melanogenesis_Homo sapiens_hsa049160.68039173
109Regulation of autophagy_Homo sapiens_hsa041400.68035040
110Olfactory transduction_Homo sapiens_hsa047400.67722913
111Nicotine addiction_Homo sapiens_hsa050330.66129805
112ABC transporters_Homo sapiens_hsa020100.65155722
113Platelet activation_Homo sapiens_hsa046110.64694115
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64494704
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64031851
116Shigellosis_Homo sapiens_hsa051310.62391845
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.62273524
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61074482
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60659440
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60613963
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60477844
122Selenocompound metabolism_Homo sapiens_hsa004500.59330645
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57540285
124Retinol metabolism_Homo sapiens_hsa008300.57167921
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.57045015
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56868333
127Rap1 signaling pathway_Homo sapiens_hsa040150.56769989
128Biosynthesis of amino acids_Homo sapiens_hsa012300.56657127
129Renal cell carcinoma_Homo sapiens_hsa052110.56079013
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55877510
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55624924
132Epstein-Barr virus infection_Homo sapiens_hsa051690.55613677
133Malaria_Homo sapiens_hsa051440.53935897
134Hepatitis B_Homo sapiens_hsa051610.53607445
135FoxO signaling pathway_Homo sapiens_hsa040680.52776474
136Chemical carcinogenesis_Homo sapiens_hsa052040.52377792
137Gap junction_Homo sapiens_hsa045400.50919078
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49853174
139Amoebiasis_Homo sapiens_hsa051460.49483289
140Axon guidance_Homo sapiens_hsa043600.48262128
141Vitamin digestion and absorption_Homo sapiens_hsa049770.46995515
1422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45957161
143Circadian rhythm_Homo sapiens_hsa047100.45802662
144mTOR signaling pathway_Homo sapiens_hsa041500.44219837
145Ovarian steroidogenesis_Homo sapiens_hsa049130.43961560
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43360352
147Huntingtons disease_Homo sapiens_hsa050160.42432883
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41397698
149Sulfur metabolism_Homo sapiens_hsa009200.40462743
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39941639
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39835908
152Vitamin B6 metabolism_Homo sapiens_hsa007500.39622565
153Viral myocarditis_Homo sapiens_hsa054160.38492775
154Carbon metabolism_Homo sapiens_hsa012000.38068773
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36803507
156Arginine and proline metabolism_Homo sapiens_hsa003300.34478616
157Arachidonic acid metabolism_Homo sapiens_hsa005900.33778821
158Fat digestion and absorption_Homo sapiens_hsa049750.33085788
159Serotonergic synapse_Homo sapiens_hsa047260.32341034
160Protein digestion and absorption_Homo sapiens_hsa049740.32059776
161cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31790092
162Sphingolipid metabolism_Homo sapiens_hsa006000.30709651
163Lysine degradation_Homo sapiens_hsa003100.30496568
164Estrogen signaling pathway_Homo sapiens_hsa049150.28991355
165Folate biosynthesis_Homo sapiens_hsa007900.28414467

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