FUT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.41141524
2bundle of His cell to Purkinje myocyte communication (GO:0086069)7.21891174
3hemidesmosome assembly (GO:0031581)6.96059560
4intestinal epithelial cell development (GO:0060576)6.30693774
5maintenance of gastrointestinal epithelium (GO:0030277)6.03883565
6regulation of water loss via skin (GO:0033561)5.78418128
7establishment of skin barrier (GO:0061436)5.50294543
8behavioral response to nicotine (GO:0035095)5.12752886
9diol metabolic process (GO:0034311)5.03519557
10keratinocyte proliferation (GO:0043616)4.95227374
11sphingoid metabolic process (GO:0046519)4.88301458
12epithelial structure maintenance (GO:0010669)4.77099803
13branching involved in prostate gland morphogenesis (GO:0060442)4.74991615
14interferon-gamma secretion (GO:0072643)4.48948495
15negative regulation of keratinocyte proliferation (GO:0010839)4.46328115
16calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.35301300
17UDP-N-acetylglucosamine metabolic process (GO:0006047)4.25236337
18multicellular organismal water homeostasis (GO:0050891)4.18622440
19keratinization (GO:0031424)4.16191544
20* L-fucose catabolic process (GO:0042355)4.13138074
21* fucose catabolic process (GO:0019317)4.13138074
22* L-fucose metabolic process (GO:0042354)4.13138074
23prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.12129920
24sphingosine metabolic process (GO:0006670)4.05317384
25cellular ketone body metabolic process (GO:0046950)4.03071949
26purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.00446030
273-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.00446030
28O-glycan processing (GO:0016266)3.91113861
29keratinocyte differentiation (GO:0030216)3.89915942
30positive regulation of respiratory burst (GO:0060267)3.82183309
31flavonoid metabolic process (GO:0009812)3.79696645
32indolalkylamine catabolic process (GO:0046218)3.77860207
33tryptophan catabolic process (GO:0006569)3.77860207
34indole-containing compound catabolic process (GO:0042436)3.77860207
35transcytosis (GO:0045056)3.75914846
36lung secretory cell differentiation (GO:0061140)3.74040062
37regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.70372514
38galactose catabolic process (GO:0019388)3.66780844
39cGMP-mediated signaling (GO:0019934)3.66625055
40indolalkylamine metabolic process (GO:0006586)3.62179825
41ketone body metabolic process (GO:1902224)3.61618387
42regulation of guanylate cyclase activity (GO:0031282)3.57698129
43sulfation (GO:0051923)3.57167405
44kynurenine metabolic process (GO:0070189)3.52791064
45hepatocyte apoptotic process (GO:0097284)3.49660120
46uterus development (GO:0060065)3.47734093
47water-soluble vitamin biosynthetic process (GO:0042364)3.47625172
48kidney morphogenesis (GO:0060993)3.47047233
49phosphatidylserine acyl-chain remodeling (GO:0036150)3.44238378
50water homeostasis (GO:0030104)3.42971972
51epidermal cell differentiation (GO:0009913)3.39838274
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33416447
53tryptophan metabolic process (GO:0006568)3.32110393
54exogenous drug catabolic process (GO:0042738)3.30669971
55sulfur amino acid catabolic process (GO:0000098)3.29906992
56response to pheromone (GO:0019236)3.28703462
57arginine metabolic process (GO:0006525)3.28582025
58positive regulation of epidermal cell differentiation (GO:0045606)3.24587743
59regulation of respiratory burst (GO:0060263)3.24561285
60prostate gland epithelium morphogenesis (GO:0060740)3.24171832
61ventricular cardiac muscle cell action potential (GO:0086005)3.24049024
62drug catabolic process (GO:0042737)3.22087024
63axoneme assembly (GO:0035082)3.20905459
64phosphatidylserine metabolic process (GO:0006658)3.20796274
65sulfate transmembrane transport (GO:1902358)3.16677706
66positive regulation of interleukin-8 secretion (GO:2000484)3.15955622
67epithelial cell maturation (GO:0002070)3.14778506
68positive regulation of epidermis development (GO:0045684)3.14757046
69detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.13330299
70N-glycan processing (GO:0006491)3.11606536
71glandular epithelial cell differentiation (GO:0002067)3.10455668
72regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.08200169
73positive regulation of guanylate cyclase activity (GO:0031284)3.06475899
74ectoderm development (GO:0007398)3.05979257
75intestinal absorption (GO:0050892)3.03373947
76vitamin transmembrane transport (GO:0035461)3.02966145
77phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.02786498
78* fucosylation (GO:0036065)3.01016217
79regulation of chemokine secretion (GO:0090196)2.99571129
80negative regulation of cell fate commitment (GO:0010454)2.97486985
81striated muscle atrophy (GO:0014891)2.94296939
82positive regulation of fatty acid beta-oxidation (GO:0032000)2.94176816
83positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.94145381
84quinone biosynthetic process (GO:1901663)2.93459970
85positive regulation of fatty acid transport (GO:2000193)2.93457444
86pyrimidine-containing compound transmembrane transport (GO:0072531)2.91141048
87positive regulation of fatty acid oxidation (GO:0046321)2.90837525
88transepithelial transport (GO:0070633)2.89305276
89phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.88953380
90epithelial cilium movement (GO:0003351)2.88708042
91peptide cross-linking (GO:0018149)2.88103684
92protein autoprocessing (GO:0016540)2.87960854
93respiratory chain complex IV assembly (GO:0008535)2.87439128
94detection of light stimulus involved in visual perception (GO:0050908)2.86593830
95detection of light stimulus involved in sensory perception (GO:0050962)2.86593830
96sulfate transport (GO:0008272)2.86156066
97nucleotide-sugar biosynthetic process (GO:0009226)2.85584067
98epidermis development (GO:0008544)2.84001179
99epithelial cell differentiation involved in prostate gland development (GO:0060742)2.81344187
100primary amino compound metabolic process (GO:1901160)2.81239669
101hormone catabolic process (GO:0042447)2.79355329
102digestion (GO:0007586)2.78767307
103regulation of interleukin-8 secretion (GO:2000482)2.78089066
104epithelial cell-cell adhesion (GO:0090136)2.77916558
105antibacterial humoral response (GO:0019731)2.77547130
106indole-containing compound metabolic process (GO:0042430)2.77338980
107positive regulation of Cdc42 GTPase activity (GO:0043089)2.76924255
108regulation of action potential (GO:0098900)2.76317583
109phosphatidylinositol acyl-chain remodeling (GO:0036149)2.75386153
110glucuronate metabolic process (GO:0019585)2.74851664
111uronic acid metabolic process (GO:0006063)2.74851664
112cellular biogenic amine catabolic process (GO:0042402)2.73701764
113amine catabolic process (GO:0009310)2.73701764
114nephron epithelium morphogenesis (GO:0072088)2.73674522
115nephron tubule morphogenesis (GO:0072078)2.73674522
116sulfur compound transport (GO:0072348)2.73631949
117DNA deamination (GO:0045006)2.73577608
118oligosaccharide biosynthetic process (GO:0009312)2.73347704
119regulation of cardioblast differentiation (GO:0051890)2.72564180
120pharyngeal system development (GO:0060037)2.72273999
121hypotonic response (GO:0006971)2.72017035
122branching involved in mammary gland duct morphogenesis (GO:0060444)2.71997426
123tight junction assembly (GO:0070830)2.71534913
124phosphatidylcholine acyl-chain remodeling (GO:0036151)2.71018745
125cilium or flagellum-dependent cell motility (GO:0001539)2.70697035
126negative regulation of T cell differentiation in thymus (GO:0033085)2.70634471
127digestive system process (GO:0022600)2.68560413
128neuronal action potential (GO:0019228)2.67959255
129antimicrobial humoral response (GO:0019730)2.67225761
130thyroid hormone metabolic process (GO:0042403)2.67195449
131cellular glucuronidation (GO:0052695)2.65402079
132skeletal muscle adaptation (GO:0043501)2.65327302
133auditory receptor cell differentiation (GO:0042491)2.64763021
134rRNA catabolic process (GO:0016075)2.64369615
135gland morphogenesis (GO:0022612)2.63877316
136ubiquinone biosynthetic process (GO:0006744)2.63165023
137cell communication involved in cardiac conduction (GO:0086065)2.62335639
138preassembly of GPI anchor in ER membrane (GO:0016254)2.61928404
139positive regulation of keratinocyte differentiation (GO:0045618)2.61267602
140cilium movement (GO:0003341)2.60925310
141cell differentiation involved in embryonic placenta development (GO:0060706)2.60380265
142regulation of viral release from host cell (GO:1902186)2.59502521
143photoreceptor cell maintenance (GO:0045494)2.59422586
144neurotransmitter metabolic process (GO:0042133)2.58297688
145potassium ion homeostasis (GO:0055075)2.58050073
146intermediate filament organization (GO:0045109)2.56967825
147positive regulation of prostaglandin secretion (GO:0032308)2.56909632
148regulation of heart rate by cardiac conduction (GO:0086091)2.56545200
149bile acid and bile salt transport (GO:0015721)2.55781510
150bicarbonate transport (GO:0015701)2.55193451
151behavioral response to ethanol (GO:0048149)2.54919248
152parturition (GO:0007567)2.54805579
153mitochondrial calcium ion transport (GO:0006851)2.54662445
154nucleotide-sugar metabolic process (GO:0009225)2.54336443
155axonemal dynein complex assembly (GO:0070286)2.53575505
156reflex (GO:0060004)2.52600888
157phospholipid scrambling (GO:0017121)2.52429873
158platelet dense granule organization (GO:0060155)2.52296792
159arginine catabolic process (GO:0006527)2.52153425
160multicellular organism reproduction (GO:0032504)2.51830754
161regulation of pH (GO:0006885)2.51014708
162detection of bacterium (GO:0016045)2.50895524
163cellular response to ATP (GO:0071318)2.50592693
164membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.50376615
165proline transport (GO:0015824)2.50331165
166NAD biosynthetic process (GO:0009435)2.50212935
167positive regulation of sodium ion transmembrane transport (GO:1902307)2.50030828
168positive regulation of icosanoid secretion (GO:0032305)2.48756344
169cardiac conduction (GO:0061337)2.47971025
170GDP-mannose metabolic process (GO:0019673)2.47722181
171regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.47715824
172negative regulation of telomere maintenance (GO:0032205)2.47353564
173negative regulation of mast cell activation (GO:0033004)2.47199393
174galactose metabolic process (GO:0006012)2.45377128
175cytochrome complex assembly (GO:0017004)2.44811429
176detection of other organism (GO:0098543)2.44793489
177columnar/cuboidal epithelial cell development (GO:0002066)2.44584271
178piRNA metabolic process (GO:0034587)2.43248306
179auditory receptor cell stereocilium organization (GO:0060088)2.42802703
180alkaloid metabolic process (GO:0009820)2.42648506
181cellular response to exogenous dsRNA (GO:0071360)2.42370844
182protein polyglutamylation (GO:0018095)2.40426795
183ubiquinone metabolic process (GO:0006743)2.39863698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.01206112
2ZNF274_21170338_ChIP-Seq_K562_Hela3.78824528
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.28080068
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.12474923
5SOX2_27498859_Chip-Seq_STOMACH_Mouse2.87538574
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.64137188
7* SOX2_20726797_ChIP-Seq_SW620_Human2.61473625
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.55347731
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.45367229
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.41124916
11EZH2_22144423_ChIP-Seq_EOC_Human2.36983104
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.31219831
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26268941
14ZNF217_24962896_ChIP-Seq_MCF-7_Human2.22328125
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.21159594
16* GATA4_25053715_ChIP-Seq_YYC3_Human2.20224461
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19559959
18GBX2_23144817_ChIP-Seq_PC3_Human2.17969220
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13497990
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.04006640
21SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.00128922
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.00128922
23TP63_17297297_ChIP-ChIP_HaCaT_Human10.0198598
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.99861311
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.93860365
26GATA6_25053715_ChIP-Seq_YYC3_Human1.93011576
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89474902
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88138336
29SOX9_24532713_ChIP-Seq_HFSC_Mouse1.81439766
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79854461
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.75353097
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.75160079
33ZNF263_19887448_ChIP-Seq_K562_Human1.74932915
34ER_23166858_ChIP-Seq_MCF-7_Human1.68761794
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68248535
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67924702
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67897898
38KLF5_25053715_ChIP-Seq_YYC3_Human1.67721022
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.67560478
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66684391
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66211878
42P300_19829295_ChIP-Seq_ESCs_Human1.63880587
43AHR_22903824_ChIP-Seq_MCF-7_Human1.63348930
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62106735
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.61952795
46FUS_26573619_Chip-Seq_HEK293_Human1.61638983
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.60323689
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58426733
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50673387
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.49255153
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49255153
52IGF1R_20145208_ChIP-Seq_DFB_Human1.49127978
53* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48323383
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48168063
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48126779
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45927153
57VDR_22108803_ChIP-Seq_LS180_Human1.45365795
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.41956423
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40949997
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37868723
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.37863909
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.37863909
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.37863909
64EWS_26573619_Chip-Seq_HEK293_Human1.37825145
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.37653345
66GATA3_24758297_ChIP-Seq_MCF-7_Human1.36857159
67TCF4_22108803_ChIP-Seq_LS180_Human1.36150660
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36084892
69DROSHA_22980978_ChIP-Seq_HELA_Human1.35641971
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34092020
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.33914860
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33792706
73RACK7_27058665_Chip-Seq_MCF-7_Human1.33608890
74FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.32482707
75SOX2_19829295_ChIP-Seq_ESCs_Human1.32448635
76NANOG_19829295_ChIP-Seq_ESCs_Human1.32448635
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32319994
78AR_25329375_ChIP-Seq_VCAP_Human1.32199331
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.31082855
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30841646
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30736428
82IRF1_19129219_ChIP-ChIP_H3396_Human1.30376387
83REST_21632747_ChIP-Seq_MESCs_Mouse1.29836638
84STAT3_23295773_ChIP-Seq_U87_Human1.29481727
85AR_20517297_ChIP-Seq_VCAP_Human1.28444093
86TP53_22573176_ChIP-Seq_HFKS_Human1.27826636
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27566860
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27547438
89NCOR_22424771_ChIP-Seq_293T_Human1.26349956
90CBP_20019798_ChIP-Seq_JUKART_Human1.25756469
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25756469
92HOXB7_26014856_ChIP-Seq_BT474_Human1.25595026
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25193597
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24997575
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24967995
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22456404
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22368136
98TCF4_23295773_ChIP-Seq_U87_Human1.21703379
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19190150
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18595819
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.18460417
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.17926545
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17813191
104PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17750344
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17631042
106RXR_22108803_ChIP-Seq_LS180_Human1.17194432
107IRF8_22096565_ChIP-ChIP_GC-B_Human1.16398887
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16307766
109SMAD4_21799915_ChIP-Seq_A2780_Human1.16259673
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15603087
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15543214
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.14738267
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14537182
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14450364
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14221495
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14073615
117TAF2_19829295_ChIP-Seq_ESCs_Human1.13853542
118TAF15_26573619_Chip-Seq_HEK293_Human1.13782557
119SMAD3_21741376_ChIP-Seq_EPCs_Human1.13772224
120CJUN_26792858_Chip-Seq_BT549_Human1.13757248
121* NANOG_20526341_ChIP-Seq_ESCs_Human1.12206373
122AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10766994
123RUNX2_22187159_ChIP-Seq_PCA_Human1.10383428
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.10331856
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.09040949
126ERA_21632823_ChIP-Seq_H3396_Human1.08810500
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08564682
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08400898
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08242151
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08242151
131KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08199619
132SMAD_19615063_ChIP-ChIP_OVARY_Human1.06560532
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05632149
134MYC_19829295_ChIP-Seq_ESCs_Human1.04455772
135FOXH1_21741376_ChIP-Seq_ESCs_Human1.02872437
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02026576
137EZH2_27294783_Chip-Seq_NPCs_Mouse1.01556868
138P53_21459846_ChIP-Seq_SAOS-2_Human1.01215711
139TP63_23658742_ChIP-Seq_EP156T_Human1.01177129
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.99982926
141BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99250348
142GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99245163
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.98843647
144NOTCH1_21737748_ChIP-Seq_TLL_Human0.97722604
145ETV1_20927104_ChIP-Seq_GIST48_Human0.96825426
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96310793
147GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96141031
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94939648
149RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94609253
150BCAT_22108803_ChIP-Seq_LS180_Human0.92733243
151ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92059788
152JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91873845
153CDX2_22108803_ChIP-Seq_LS180_Human0.89893131
154FOXA1_25552417_ChIP-Seq_VCAP_Human0.89629562
155TP53_16413492_ChIP-PET_HCT116_Human0.88055505
156ATF3_27146783_Chip-Seq_COLON_Human0.87264991
157SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83945083
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81202942
159CLOCK_20551151_ChIP-Seq_293T_Human0.80920172
160NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80453044
161NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80453044
162SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80367085
163ISL1_27105846_Chip-Seq_CPCs_Mouse0.79866452
164SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.79748403
165* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78987992
166JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78932959
167EED_16625203_ChIP-ChIP_MESCs_Mouse0.78854110
168ERG_21242973_ChIP-ChIP_JURKAT_Human0.78787947
169TP63_22573176_ChIP-Seq_HFKS_Human0.77331263
170JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77049496
171EZH2_27294783_Chip-Seq_ESCs_Mouse0.76244456
172SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76164688
173SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73162060
174RNF2_18974828_ChIP-Seq_MESCs_Mouse0.72562406
175EZH2_18974828_ChIP-Seq_MESCs_Mouse0.72562406
176SUZ12_27294783_Chip-Seq_ESCs_Mouse0.72154249
177IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.69707725
178FOXA2_19822575_ChIP-Seq_HepG2_Human0.69652574
179TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68263151
180SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.67204275
181PPARA_22158963_ChIP-Seq_LIVER_Mouse0.66419659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.37544632
2MP0008004_abnormal_stomach_pH4.13028425
3MP0002796_impaired_skin_barrier4.07643401
4MP0000537_abnormal_urethra_morphology3.47580254
5MP0004264_abnormal_extraembryonic_tissu3.45017618
6MP0003941_abnormal_skin_development3.35787118
7MP0001873_stomach_inflammation3.12034662
8MP0006054_spinal_hemorrhage3.09159614
9MP0003195_calcinosis2.77261024
10MP0010678_abnormal_skin_adnexa2.61461748
11MP0000566_synostosis2.58265647
12MP0005275_abnormal_skin_tensile2.51024353
13MP0005501_abnormal_skin_physiology2.50583517
14MP0008872_abnormal_physiological_respon2.49870276
15MP0005360_urolithiasis2.46188844
16MP0002254_reproductive_system_inflammat2.42063007
17MP0000462_abnormal_digestive_system2.25010547
18MP0001664_abnormal_digestion2.23499306
19MP0002060_abnormal_skin_morphology2.19466262
20MP0005365_abnormal_bile_salt2.16672990
21MP0003866_abnormal_defecation2.12765371
22MP0001666_abnormal_nutrient_absorption2.09724201
23MP0000538_abnormal_urinary_bladder2.09668399
24MP0003300_gastrointestinal_ulcer2.08301836
25MP0002098_abnormal_vibrissa_morphology2.07912489
26MP0001485_abnormal_pinna_reflex2.06742065
27MP0001501_abnormal_sleep_pattern2.06229562
28MP0005551_abnormal_eye_electrophysiolog2.02555823
29MP0001216_abnormal_epidermal_layer2.02544212
30MP0002102_abnormal_ear_morphology2.00672454
31MP0010155_abnormal_intestine_physiology1.98770533
32MP0001849_ear_inflammation1.96231913
33MP0004885_abnormal_endolymph1.95294917
34MP0002139_abnormal_hepatobiliary_system1.87140624
35MP0002138_abnormal_hepatobiliary_system1.85476323
36MP0002009_preneoplasia1.84256376
37MP0002653_abnormal_ependyma_morphology1.82527749
38MP0003315_abnormal_perineum_morphology1.82024917
39MP0000383_abnormal_hair_follicle1.80310419
40MP0005310_abnormal_salivary_gland1.80114273
41MP0003453_abnormal_keratinocyte_physiol1.77752058
42MP0009384_cardiac_valve_regurgitation1.74019761
43MP0004947_skin_inflammation1.72584270
44MP0000516_abnormal_urinary_system1.70582063
45MP0005367_renal/urinary_system_phenotyp1.70582063
46MP0001765_abnormal_ion_homeostasis1.68462923
47MP0002166_altered_tumor_susceptibility1.62138696
48MP0008877_abnormal_DNA_methylation1.59607652
49MP0000470_abnormal_stomach_morphology1.58168874
50MP0010771_integument_phenotype1.57333095
51MP0002822_catalepsy1.57301774
52MP0001968_abnormal_touch/_nociception1.56136136
53MP0000467_abnormal_esophagus_morphology1.55122580
54MP0005645_abnormal_hypothalamus_physiol1.54493438
55MP0009745_abnormal_behavioral_response1.54212237
56MP0001986_abnormal_taste_sensitivity1.53652409
57MP0010386_abnormal_urinary_bladder1.49772376
58MP0005377_hearing/vestibular/ear_phenot1.48779817
59MP0003878_abnormal_ear_physiology1.48779817
60* MP0005381_digestive/alimentary_phenotyp1.48384366
61MP0000490_abnormal_crypts_of1.48340534
62MP0000477_abnormal_intestine_morphology1.47775642
63MP0000579_abnormal_nail_morphology1.44389149
64MP0002006_tumorigenesis1.41817163
65MP0003705_abnormal_hypodermis_morpholog1.41555437
66MP0002733_abnormal_thermal_nociception1.40156589
67MP0002272_abnormal_nervous_system1.40037781
68MP0004133_heterotaxia1.38311074
69MP0002837_dystrophic_cardiac_calcinosis1.38305074
70MP0005332_abnormal_amino_acid1.38147215
71* MP0001663_abnormal_digestive_system1.37409043
72MP0010352_gastrointestinal_tract_polyps1.36939292
73MP0003566_abnormal_cell_adhesion1.35061288
74MP0000377_abnormal_hair_follicle1.34729840
75MP0000230_abnormal_systemic_arterial1.31883078
76MP0010329_abnormal_lipoprotein_level1.30742826
77MP0001346_abnormal_lacrimal_gland1.30109363
78MP0004782_abnormal_surfactant_physiolog1.29080115
79MP0000631_abnormal_neuroendocrine_gland1.29058542
80MP0001970_abnormal_pain_threshold1.26804587
81MP0003646_muscle_fatigue1.26683042
82MP0000613_abnormal_salivary_gland1.26021829
83MP0003011_delayed_dark_adaptation1.25665591
84MP0009379_abnormal_foot_pigmentation1.25221373
85MP0002163_abnormal_gland_morphology1.25194893
86MP0000762_abnormal_tongue_morphology1.23705128
87MP0004043_abnormal_pH_regulation1.23597537
88MP0005083_abnormal_biliary_tract1.23308337
89MP0003136_yellow_coat_color1.22593940
90MP0005647_abnormal_sex_gland1.21473579
91MP0005174_abnormal_tail_pigmentation1.21199208
92MP0003718_maternal_effect1.20935680
93MP0002876_abnormal_thyroid_physiology1.20856522
94MP0004742_abnormal_vestibular_system1.20314422
95MP0003787_abnormal_imprinting1.18109087
96MP0009046_muscle_twitch1.16376878
97MP0004142_abnormal_muscle_tone1.14864501
98MP0002736_abnormal_nociception_after1.14771873
99MP0004215_abnormal_myocardial_fiber1.12655076
100MP0002735_abnormal_chemical_nociception1.11112898
101MP0005167_abnormal_blood-brain_barrier1.08872802
102MP0006072_abnormal_retinal_apoptosis1.07092268
103MP0001502_abnormal_circadian_rhythm1.06852489
104MP0002938_white_spotting1.04651950
105MP0002909_abnormal_adrenal_gland1.02223190
106MP0006292_abnormal_olfactory_placode1.02068922
107MP0002277_abnormal_respiratory_mucosa1.01749094
108MP0009780_abnormal_chondrocyte_physiolo1.01588094
109MP0005253_abnormal_eye_physiology1.01393038
110MP0003283_abnormal_digestive_organ1.01290651
111MP0005636_abnormal_mineral_homeostasis1.01280731
112MP0000427_abnormal_hair_cycle1.00493442
113MP0005646_abnormal_pituitary_gland0.99542852
114MP0008775_abnormal_heart_ventricle0.99147467
115MP0004858_abnormal_nervous_system0.99075165
116MP0003879_abnormal_hair_cell0.98974351
117MP0002638_abnormal_pupillary_reflex0.97990147
118MP0001486_abnormal_startle_reflex0.97932558
119MP0001764_abnormal_homeostasis0.96307728
120MP0005248_abnormal_Harderian_gland0.96237691
121MP0002064_seizures0.95660431
122MP0005448_abnormal_energy_balance0.95006516
123MP0000647_abnormal_sebaceous_gland0.94895230
124MP0005670_abnormal_white_adipose0.94393216
125MP0000372_irregular_coat_pigmentation0.94217776
126MP0004381_abnormal_hair_follicle0.91636473
127MP0000569_abnormal_digit_pigmentation0.91088955
128MP0009931_abnormal_skin_appearance0.90434312
129MP0006276_abnormal_autonomic_nervous0.90281482
130MP0002557_abnormal_social/conspecific_i0.89667421
131MP0001756_abnormal_urination0.89146811
132MP0003119_abnormal_digestive_system0.87837705
133MP0009643_abnormal_urine_homeostasis0.86631031
134MP0000026_abnormal_inner_ear0.86610921
135MP0003191_abnormal_cellular_cholesterol0.85958805
136MP0002572_abnormal_emotion/affect_behav0.85209873
137MP0008875_abnormal_xenobiotic_pharmacok0.85206320
138MP0005166_decreased_susceptibility_to0.84498834
139MP0004019_abnormal_vitamin_homeostasis0.83987041
140MP0001905_abnormal_dopamine_level0.83843682
141MP0001188_hyperpigmentation0.83072187
142MP0001191_abnormal_skin_condition0.82538210
143MP0000627_abnormal_mammary_gland0.81163364
144MP0002160_abnormal_reproductive_system0.80977979
145MP0002693_abnormal_pancreas_physiology0.80942477
146MP0002734_abnormal_mechanical_nocicepti0.80651232
147MP0004272_abnormal_basement_membrane0.80533945
148MP0005389_reproductive_system_phenotype0.79593728
149MP0004185_abnormal_adipocyte_glucose0.76743251
150MP0009053_abnormal_anal_canal0.72516738
151MP0002234_abnormal_pharynx_morphology0.71182134
152MP0009764_decreased_sensitivity_to0.71093079
153MP0002136_abnormal_kidney_physiology0.70144705
154MP0005023_abnormal_wound_healing0.67028250
155MP0003252_abnormal_bile_duct0.67027289
156MP0000465_gastrointestinal_hemorrhage0.65624558
157MP0001881_abnormal_mammary_gland0.61455094
158MP0002896_abnormal_bone_mineralization0.61107770
159MP0003936_abnormal_reproductive_system0.59505269
160MP0003638_abnormal_response/metabolism_0.59488153
161MP0000367_abnormal_coat/_hair0.59486606
162MP0003183_abnormal_peptide_metabolism0.59124010
163MP0005187_abnormal_penis_morphology0.54317671
164MP0003045_fibrosis0.52601323
165MP0004147_increased_porphyrin_level0.51675336
166MP0003693_abnormal_embryo_hatching0.51547500
167MP0005085_abnormal_gallbladder_physiolo0.50919823

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.32303759
2Onycholysis (HP:0001806)6.57957521
3Fragile nails (HP:0001808)4.96042033
4Milia (HP:0001056)4.91492134
5Plantar hyperkeratosis (HP:0007556)4.72272030
6Decreased circulating renin level (HP:0003351)4.38622314
7Woolly hair (HP:0002224)4.37345128
8Atrophic scars (HP:0001075)4.29767201
9Pancreatic cysts (HP:0001737)4.11435132
10Molar tooth sign on MRI (HP:0002419)3.98545384
11Abnormality of midbrain morphology (HP:0002418)3.98545384
12Congenital stationary night blindness (HP:0007642)3.95523021
13True hermaphroditism (HP:0010459)3.72075664
14Pancreatic fibrosis (HP:0100732)3.70677359
15Pili torti (HP:0003777)3.56987779
16Symphalangism affecting the phalanges of the hand (HP:0009773)3.46409811
17Congenital ichthyosiform erythroderma (HP:0007431)3.44061708
18Abnormality of renin-angiotensin system (HP:0000847)3.38969821
19Abnormality of the renal cortex (HP:0011035)3.35502128
20Lip pit (HP:0100267)3.32676956
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.28483234
22Absent/shortened dynein arms (HP:0200106)3.28483234
23Tubular atrophy (HP:0000092)3.27507871
24Nephronophthisis (HP:0000090)3.26839699
25Metabolic alkalosis (HP:0200114)3.26748105
26Hyperactive renin-angiotensin system (HP:0000841)3.18107465
27Abnormality of secondary sexual hair (HP:0009888)3.17043510
28Abnormality of the axillary hair (HP:0100134)3.17043510
29Curly hair (HP:0002212)3.15709609
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.13988427
31Ureteral stenosis (HP:0000071)3.13030409
32Palmoplantar hyperkeratosis (HP:0000972)3.05673873
33Abnormality of the renal medulla (HP:0100957)3.01391362
34Hypoplasia of dental enamel (HP:0006297)3.00221775
35Pustule (HP:0200039)2.99817128
36Abdominal distention (HP:0003270)2.97221373
37Ureteral obstruction (HP:0006000)2.94361491
38Alkalosis (HP:0001948)2.91086665
39Nail dystrophy (HP:0008404)2.86819682
40Abnormality of the 2nd finger (HP:0004100)2.85837305
41Palmar hyperkeratosis (HP:0010765)2.82958305
42Abolished electroretinogram (ERG) (HP:0000550)2.82941768
43Ventricular tachycardia (HP:0004756)2.81746429
44Septate vagina (HP:0001153)2.80033080
45Alopecia of scalp (HP:0002293)2.78922527
46Pendular nystagmus (HP:0012043)2.77885339
47Hyperventilation (HP:0002883)2.75753929
48Type II lissencephaly (HP:0007260)2.74487772
49Cystic liver disease (HP:0006706)2.71313394
50Hypotrichosis (HP:0001006)2.67924442
51Abnormal respiratory epithelium morphology (HP:0012253)2.67707748
52Abnormal respiratory motile cilium morphology (HP:0005938)2.67707748
53Mildly elevated creatine phosphokinase (HP:0008180)2.67264402
54Abnormality of alanine metabolism (HP:0010916)2.65573605
55Hyperalaninemia (HP:0003348)2.65573605
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65573605
57Fragile skin (HP:0001030)2.65268406
58Ileus (HP:0002595)2.63815308
59Furrowed tongue (HP:0000221)2.62309026
60Abnormality of the 1st metacarpal (HP:0010009)2.61984899
61Congenital, generalized hypertrichosis (HP:0004540)2.60460502
62Congenital sensorineural hearing impairment (HP:0008527)2.57946917
63Inability to walk (HP:0002540)2.55129168
64Biliary tract neoplasm (HP:0100574)2.54338211
65Abnormality of vitamin B metabolism (HP:0004340)2.54090149
66Attenuation of retinal blood vessels (HP:0007843)2.52662961
67Aplasia involving bones of the upper limbs (HP:0009823)2.50821431
68Aplasia of the phalanges of the hand (HP:0009802)2.50821431
69Aplasia involving bones of the extremities (HP:0009825)2.50821431
70Abnormality of the gastric mucosa (HP:0004295)2.49722210
71Decreased central vision (HP:0007663)2.49409047
72Concave nail (HP:0001598)2.48465014
73Abnormality of the vitamin B12 metabolism (HP:0004341)2.45832286
74Chronic hepatic failure (HP:0100626)2.45699878
75Abnormality of the middle phalanges of the toes (HP:0010183)2.44589461
76Abnormal rod and cone electroretinograms (HP:0008323)2.43998183
77Corneal erosion (HP:0200020)2.40364558
78Short hallux (HP:0010109)2.40117266
79Abnormality of chloride homeostasis (HP:0011422)2.36828604
80Abnormal blistering of the skin (HP:0008066)2.35660028
81Dehydration (HP:0001944)2.34870517
82Ectropion (HP:0000656)2.34811289
83Stomach cancer (HP:0012126)2.33954692
84Hyperaldosteronism (HP:0000859)2.33871683
85Large for gestational age (HP:0001520)2.32746531
86Hyperglycinuria (HP:0003108)2.31651460
87Confusion (HP:0001289)2.31642385
88Medial flaring of the eyebrow (HP:0010747)2.31517424
89Polydipsia (HP:0001959)2.31254596
90Abnormal drinking behavior (HP:0030082)2.31254596
91Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.29297789
92Increased IgE level (HP:0003212)2.29084018
93Abnormal ciliary motility (HP:0012262)2.27466908
94Aortic dissection (HP:0002647)2.26497533
95Malnutrition (HP:0004395)2.26151104
96Aplasia cutis congenita (HP:0001057)2.22657081
97Hypothermia (HP:0002045)2.20094480
98Popliteal pterygium (HP:0009756)2.17294437
99Abnormality of nail color (HP:0100643)2.16232005
100Villous atrophy (HP:0011473)2.13788632
101Abnormality of small intestinal villus morphology (HP:0011472)2.13788632
102Widely patent fontanelles and sutures (HP:0004492)2.13093540
103Hyperparathyroidism (HP:0000843)2.12602803
104Rectal prolapse (HP:0002035)2.12529384
105Micronodular cirrhosis (HP:0001413)2.11189707
106Hypoplastic labia majora (HP:0000059)2.10657625
107Hypoplasia of the uterus (HP:0000013)2.10188212
108Chorioretinal atrophy (HP:0000533)2.10167075
109Abnormal hair laboratory examination (HP:0003328)2.09338817
110Flat acetabular roof (HP:0003180)2.08555880
111Abnormality of cochlea (HP:0000375)2.08436789
112Aplasia/Hypoplasia of the hallux (HP:0008362)2.06689207
113Increased corneal curvature (HP:0100692)2.06321316
114Keratoconus (HP:0000563)2.06321316
115Polyuria (HP:0000103)2.06056911
116Pterygium (HP:0001059)2.05326646
117Cupped ribs (HP:0000887)2.05199923
118Abnormal respiratory motile cilium physiology (HP:0012261)2.04837513
119Absent phalangeal crease (HP:0006109)2.04357768
120Gaze-evoked nystagmus (HP:0000640)2.03420496
121Abnormality of renal excretion (HP:0011036)2.02522339
122Congenital hepatic fibrosis (HP:0002612)2.02386430
123Sclerocornea (HP:0000647)2.02089755
124Progressive sensorineural hearing impairment (HP:0000408)2.01318425
125Male pseudohermaphroditism (HP:0000037)2.00954293
126Genetic anticipation (HP:0003743)2.00787876
127Abnormality of the distal phalanx of the thumb (HP:0009617)2.00201662
128Renal cortical cysts (HP:0000803)2.00094801
129Vacuolated lymphocytes (HP:0001922)2.00071682
130Abnormality of the proximal phalanges of the hand (HP:0009834)1.99945103
131Aortic aneurysm (HP:0004942)1.99781018
132Abnormal finger flexion creases (HP:0006143)1.98678090
133Ventricular fibrillation (HP:0001663)1.98531419
134Abnormality of glycine metabolism (HP:0010895)1.98438387
135Abnormality of serine family amino acid metabolism (HP:0010894)1.98438387
136Vascular calcification (HP:0004934)1.97776582
137Methylmalonic aciduria (HP:0012120)1.97003567
138Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96589805
139Cone-rod dystrophy (HP:0000548)1.96324438
140Abnormal tarsal ossification (HP:0008369)1.95666947
141Progressive inability to walk (HP:0002505)1.93499502
142Glycosuria (HP:0003076)1.93224034
143Abnormality of urine glucose concentration (HP:0011016)1.93224034
144Abnormality of proline metabolism (HP:0010907)1.93090656
145Hydroxyprolinuria (HP:0003080)1.93090656
146Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92986248
147Focal segmental glomerulosclerosis (HP:0000097)1.91674311
148Hypokalemia (HP:0002900)1.91591081
149Mucopolysacchariduria (HP:0008155)1.91557258
150Urinary glycosaminoglycan excretion (HP:0003541)1.91557258
151Abnormal biliary tract morphology (HP:0012440)1.91514972
152Syncope (HP:0001279)1.91509244
153Palpitations (HP:0001962)1.90578878
154Distal lower limb muscle weakness (HP:0009053)1.89437819
155Progressive cerebellar ataxia (HP:0002073)1.88992377
156Chronic bronchitis (HP:0004469)1.88756775
157Hypoplastic nipples (HP:0002557)1.88710888
158Abnormality of the labia majora (HP:0012881)1.86605955
159Fibular aplasia (HP:0002990)1.86410585
160Goiter (HP:0000853)1.85958863
161Renal salt wasting (HP:0000127)1.84855692
162Conjunctival hamartoma (HP:0100780)1.84832204
163Abnormality of macular pigmentation (HP:0008002)1.84390250
164Hypoalbuminemia (HP:0003073)1.83738516
165Abnormal albumin level (HP:0012116)1.83738516
166Severe muscular hypotonia (HP:0006829)1.83057995
167Abnormal urine output (HP:0012590)1.82955225
168Abnormal foot bone ossification (HP:0010675)1.82667950
169Abnormality of vitamin metabolism (HP:0100508)1.81741610
170Amelogenesis imperfecta (HP:0000705)1.81570298
171Abnormality of the pons (HP:0007361)1.81547044
172Abnormal vertebral ossification (HP:0100569)1.80980215
173Methylmalonic acidemia (HP:0002912)1.80716602
174Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80711004
175Abnormality of polysaccharide metabolism (HP:0011012)1.80711004
176Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80711004
177Bile duct proliferation (HP:0001408)1.79890362
178Abnormal biliary tract physiology (HP:0012439)1.79890362
179Fatigable weakness (HP:0003473)1.79312689
180Abnormality of the neuromuscular junction (HP:0003398)1.79312689
181Bronchiectasis (HP:0002110)1.78781438
182Anencephaly (HP:0002323)1.78466735
183Abnormality of potassium homeostasis (HP:0011042)1.77859943
184Ketosis (HP:0001946)1.76791536
185Ketoacidosis (HP:0001993)1.74307989
186Delayed CNS myelination (HP:0002188)1.73874422
187Optic disc pallor (HP:0000543)1.73751920
188Tachypnea (HP:0002789)1.73024055
189Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71399407
190Aplasia/hypoplasia of the uterus (HP:0008684)1.71076192
1913-Methylglutaconic aciduria (HP:0003535)1.71006602
192Occipital encephalocele (HP:0002085)1.70757850
193Aplasia/Hypoplasia of the tongue (HP:0010295)1.70411009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.01057179
2MST1R5.00247436
3AKT34.28596326
4ACVR1B4.26525795
5FRK4.24476518
6ADRBK24.18438105
7EPHA23.76547626
8DDR23.32814551
9ERN12.64629637
10WNK42.63983492
11MAP2K22.61398731
12TLK12.52428167
13BMPR1B2.51975321
14LATS12.50588252
15ZAK2.35772259
16MYLK2.25651797
17MAP4K22.23055929
18PINK12.19541593
19LMTK22.18988915
20PIK3CA2.14466887
21FER2.09985243
22PTK62.08638317
23MAP3K22.03253668
24EPHB21.97819328
25WNK31.93589016
26MET1.84257680
27TESK11.76215950
28ERBB41.72226803
29DAPK21.65882938
30MAPKAPK31.64570234
31TNIK1.54347211
32DMPK1.51351331
33TAOK31.50503869
34NUAK11.39087864
35MAPK131.37606615
36MATK1.35229983
37MAPK151.33915097
38PIK3CG1.30032050
39PDK21.29288882
40STK391.27238015
41ADRBK11.26879739
42RPS6KB21.22447868
43RIPK11.17047593
44STK101.16725152
45TXK1.16094662
46PRKG21.09292852
47MAP2K11.03554155
48TRPM71.02808336
49MAP3K41.02431059
50INSRR1.00383789
51EEF2K0.96583745
52LRRK20.94072751
53MAP3K30.93871771
54PTK20.93466468
55NLK0.93010174
56PRKCI0.92822029
57PHKG20.89872107
58PHKG10.89872107
59TGFBR10.89657741
60PDGFRA0.89569943
61TBK10.89216690
62BRAF0.83791679
63PRKCG0.83706920
64DYRK20.81931179
65MKNK20.81441579
66STK38L0.80662438
67BRSK20.79071889
68TTN0.77836227
69IKBKB0.76386539
70CDC42BPA0.75671308
71CAMKK20.75227211
72CASK0.75021117
73NTRK30.74073304
74MAP3K140.72226097
75NME10.71806007
76FGR0.71784093
77PRKCQ0.71582115
78LIMK10.71078490
79PTK2B0.70944267
80TAOK10.69172055
81GRK10.66668182
82STK30.60998185
83OXSR10.56519343
84MAP3K70.56100050
85IKBKE0.55648603
86PNCK0.54585315
87TYRO30.53545922
88CHUK0.53388543
89IRAK30.53163467
90EPHB10.52495564
91PDPK10.52058437
92MAPKAPK50.51760535
93PAK40.51664680
94CSNK1A10.51171856
95MAP3K80.51025578
96MAP3K10.51019914
97GRK60.50909128
98CAMK2A0.50492381
99ROCK10.50136227
100ERBB20.48628055
101PIM20.46786667
102MARK10.46580065
103PRKACA0.46152108
104MAP2K70.44482530
105CSNK1G10.44093586
106FGFR20.43584699
107DYRK1B0.43215822
108KIT0.43176605
109BCR0.42841098
110PRKCZ0.42766382
111MAP2K60.42727703
112ITK0.42189838
113CSK0.41966672
114PAK20.40778518
115PAK30.40561732
116EPHA40.40408977
117TRIM280.40087775
118IRAK10.40012697
119CSNK1G20.38621813
120RPS6KA50.38353760
121TIE10.38179797
122SRC0.38177284
123TGFBR20.37729676
124NEK20.37615163
125KSR20.37467481
126AKT20.37373952
127TYK20.35835682
128IGF1R0.34264938
129SIK10.34043975
130TEC0.33965202
131PRKAA20.33827801
132ROCK20.33510032
133CSNK1G30.33089220
134PRKCE0.31801099
135PDK10.31546766
136ICK0.30665987
137MUSK0.30148756
138CAMK2D0.29845953
139STK110.29144166
140PRKCA0.28289729
141CSNK1A1L0.28254627
142VRK10.27697269
143TNK20.27564619
144ERBB30.27054530
145MAP3K120.26672888
146BCKDK0.25811862
147PDGFRB0.25404835
148PRKACG0.24839133
149MAPKAPK20.20646564
150STK240.19709130
151RPS6KA20.19560526
152AURKB0.18713696
153CAMK2G0.18549766
154FYN0.17252285
155JAK20.16403392
156PRKAA10.15858993
157FGFR30.15442573
158KDR0.14751500
159EPHA30.11297606
160RPS6KA10.10315586

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.98846821
2Mineral absorption_Homo sapiens_hsa049783.20828648
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.03703460
4Nitrogen metabolism_Homo sapiens_hsa009102.85106594
5* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.61633425
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.47357847
7Linoleic acid metabolism_Homo sapiens_hsa005912.21052196
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10052744
9Butanoate metabolism_Homo sapiens_hsa006502.08283793
10Fat digestion and absorption_Homo sapiens_hsa049752.04941026
11Tight junction_Homo sapiens_hsa045302.03390434
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.97361944
13Tryptophan metabolism_Homo sapiens_hsa003801.94858445
14Sphingolipid metabolism_Homo sapiens_hsa006001.80220491
15Selenocompound metabolism_Homo sapiens_hsa004501.76731310
16Phototransduction_Homo sapiens_hsa047441.75438174
17* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71143151
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68312031
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.66880354
20Adherens junction_Homo sapiens_hsa045201.61760427
21Arachidonic acid metabolism_Homo sapiens_hsa005901.58714299
22Pancreatic secretion_Homo sapiens_hsa049721.55366930
23ECM-receptor interaction_Homo sapiens_hsa045121.44110300
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42685499
25Gastric acid secretion_Homo sapiens_hsa049711.42243587
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38579984
27Bladder cancer_Homo sapiens_hsa052191.37315792
28Other glycan degradation_Homo sapiens_hsa005111.36927777
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35178161
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.34769097
31Nicotine addiction_Homo sapiens_hsa050331.31889236
32Histidine metabolism_Homo sapiens_hsa003401.30511026
33Thyroid hormone synthesis_Homo sapiens_hsa049181.30132643
34Oxidative phosphorylation_Homo sapiens_hsa001901.29944620
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28745445
36Thyroid cancer_Homo sapiens_hsa052161.28102893
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26451142
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19490738
39Peroxisome_Homo sapiens_hsa041461.17529821
40Fructose and mannose metabolism_Homo sapiens_hsa000511.17166469
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16994137
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15912334
43Protein digestion and absorption_Homo sapiens_hsa049741.13867907
44Hepatitis C_Homo sapiens_hsa051601.13050588
45Salivary secretion_Homo sapiens_hsa049701.12829001
46Taste transduction_Homo sapiens_hsa047421.12177559
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09033629
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08927634
49Asthma_Homo sapiens_hsa053101.07800590
50Chemical carcinogenesis_Homo sapiens_hsa052041.07483864
51Ether lipid metabolism_Homo sapiens_hsa005651.04751449
52Renin-angiotensin system_Homo sapiens_hsa046141.03873707
53Bile secretion_Homo sapiens_hsa049761.02521916
54Propanoate metabolism_Homo sapiens_hsa006401.01285707
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00326420
56ABC transporters_Homo sapiens_hsa020100.99210586
57Insulin secretion_Homo sapiens_hsa049110.96149090
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.94990335
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.93241690
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.90956200
61Amoebiasis_Homo sapiens_hsa051460.90656913
62Focal adhesion_Homo sapiens_hsa045100.88502665
63Toxoplasmosis_Homo sapiens_hsa051450.88316367
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86472503
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85953987
66N-Glycan biosynthesis_Homo sapiens_hsa005100.85676900
67Small cell lung cancer_Homo sapiens_hsa052220.84752541
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83160448
69Parkinsons disease_Homo sapiens_hsa050120.80783455
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79644854
71Galactose metabolism_Homo sapiens_hsa000520.79098613
72beta-Alanine metabolism_Homo sapiens_hsa004100.78876694
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78481214
74Retinol metabolism_Homo sapiens_hsa008300.77092283
75Hippo signaling pathway_Homo sapiens_hsa043900.76521417
76Serotonergic synapse_Homo sapiens_hsa047260.75980755
77Salmonella infection_Homo sapiens_hsa051320.74711608
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74007905
79Vibrio cholerae infection_Homo sapiens_hsa051100.73671114
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73224350
81Glutathione metabolism_Homo sapiens_hsa004800.72650677
82Arginine biosynthesis_Homo sapiens_hsa002200.72498084
83Arginine and proline metabolism_Homo sapiens_hsa003300.72309588
84Type I diabetes mellitus_Homo sapiens_hsa049400.72237270
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.70710868
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68348931
87Morphine addiction_Homo sapiens_hsa050320.66424350
88TGF-beta signaling pathway_Homo sapiens_hsa043500.65847830
89Sulfur relay system_Homo sapiens_hsa041220.64358269
90Olfactory transduction_Homo sapiens_hsa047400.63962557
91Fatty acid biosynthesis_Homo sapiens_hsa000610.62585753
92Vitamin digestion and absorption_Homo sapiens_hsa049770.62271963
93Proteoglycans in cancer_Homo sapiens_hsa052050.61807634
94Ovarian steroidogenesis_Homo sapiens_hsa049130.61691875
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59297911
96Cardiac muscle contraction_Homo sapiens_hsa042600.59237076
97Fatty acid degradation_Homo sapiens_hsa000710.58276360
98VEGF signaling pathway_Homo sapiens_hsa043700.58200563
99African trypanosomiasis_Homo sapiens_hsa051430.58074382
100Caffeine metabolism_Homo sapiens_hsa002320.58005411
101Endometrial cancer_Homo sapiens_hsa052130.57375012
102Alzheimers disease_Homo sapiens_hsa050100.56827897
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.56774181
104Pertussis_Homo sapiens_hsa051330.56127343
105* Metabolic pathways_Homo sapiens_hsa011000.55971426
106Prostate cancer_Homo sapiens_hsa052150.55703403
107Starch and sucrose metabolism_Homo sapiens_hsa005000.55064657
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52654900
109Huntingtons disease_Homo sapiens_hsa050160.50630670
110Basal transcription factors_Homo sapiens_hsa030220.50205739
111Circadian entrainment_Homo sapiens_hsa047130.49808664
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49444832
113GnRH signaling pathway_Homo sapiens_hsa049120.49444365
114Rap1 signaling pathway_Homo sapiens_hsa040150.49080818
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.48812332
116Melanoma_Homo sapiens_hsa052180.48775975
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48673420
118Graft-versus-host disease_Homo sapiens_hsa053320.48583905
119Glycerolipid metabolism_Homo sapiens_hsa005610.48552127
120Influenza A_Homo sapiens_hsa051640.48337402
121Glutamatergic synapse_Homo sapiens_hsa047240.47965243
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47676594
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47535973
124Allograft rejection_Homo sapiens_hsa053300.46217143
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45909974
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45690422
127Protein export_Homo sapiens_hsa030600.43478693
128Homologous recombination_Homo sapiens_hsa034400.42815031
129Dilated cardiomyopathy_Homo sapiens_hsa054140.42656556
130Inositol phosphate metabolism_Homo sapiens_hsa005620.41969454
131Renin secretion_Homo sapiens_hsa049240.41865178
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.41806965
133Gap junction_Homo sapiens_hsa045400.40411750
134Calcium signaling pathway_Homo sapiens_hsa040200.40138968
135Basal cell carcinoma_Homo sapiens_hsa052170.40077247
136TNF signaling pathway_Homo sapiens_hsa046680.39888135
137Regulation of autophagy_Homo sapiens_hsa041400.39244740
138Dorso-ventral axis formation_Homo sapiens_hsa043200.38501581
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38401139
140ErbB signaling pathway_Homo sapiens_hsa040120.38093628
141Autoimmune thyroid disease_Homo sapiens_hsa053200.38054492
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.37905858
143Primary immunodeficiency_Homo sapiens_hsa053400.36972871
144PPAR signaling pathway_Homo sapiens_hsa033200.36892568
145Pathways in cancer_Homo sapiens_hsa052000.36545629
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35463801
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.34807373
148One carbon pool by folate_Homo sapiens_hsa006700.34449192
149Choline metabolism in cancer_Homo sapiens_hsa052310.34302699
150Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34214844
151Fatty acid metabolism_Homo sapiens_hsa012120.33551562
152Melanogenesis_Homo sapiens_hsa049160.32704913
153GABAergic synapse_Homo sapiens_hsa047270.32389010
154Collecting duct acid secretion_Homo sapiens_hsa049660.31321871
155RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30593971
156Estrogen signaling pathway_Homo sapiens_hsa049150.30591762

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