FUT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)5.95439132
2angiotensin maturation (GO:0002003)5.48710382
3regulation of guanylate cyclase activity (GO:0031282)5.46263139
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.29395862
5vitamin transmembrane transport (GO:0035461)5.04404244
6epoxygenase P450 pathway (GO:0019373)4.85866641
7exogenous drug catabolic process (GO:0042738)4.55773305
8drug catabolic process (GO:0042737)4.55248579
9ethanol oxidation (GO:0006069)4.42573194
10positive regulation of guanylate cyclase activity (GO:0031284)4.34310615
11transepithelial transport (GO:0070633)4.29513303
12flavonoid metabolic process (GO:0009812)4.16058370
13drug metabolic process (GO:0017144)4.15556107
14very-low-density lipoprotein particle assembly (GO:0034379)4.12591635
15arginine metabolic process (GO:0006525)4.09013186
16ethanol metabolic process (GO:0006067)4.07635727
17uronic acid metabolic process (GO:0006063)4.07583156
18glucuronate metabolic process (GO:0019585)4.07583156
19maintenance of gastrointestinal epithelium (GO:0030277)4.03829306
20cellular glucuronidation (GO:0052695)4.01678084
21fat-soluble vitamin biosynthetic process (GO:0042362)3.96787728
22primary alcohol catabolic process (GO:0034310)3.79678874
23regulation of systemic arterial blood pressure by hormone (GO:0001990)3.75889184
24regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.75889184
25endocrine process (GO:0050886)3.75889184
26bile acid and bile salt transport (GO:0015721)3.71363420
27regulation of triglyceride catabolic process (GO:0010896)3.69806631
28intestinal cholesterol absorption (GO:0030299)3.62168840
29drug transmembrane transport (GO:0006855)3.61779620
30plasma lipoprotein particle assembly (GO:0034377)3.57585587
313-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.56012400
32purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.56012400
33positive regulation of respiratory burst (GO:0060267)3.55735203
34glutathione biosynthetic process (GO:0006750)3.54878108
35regulation of bile acid biosynthetic process (GO:0070857)3.54083189
36calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.47007778
37sulfate transmembrane transport (GO:1902358)3.46601647
38bile acid metabolic process (GO:0008206)3.41676971
39protein-lipid complex remodeling (GO:0034368)3.40131374
40macromolecular complex remodeling (GO:0034367)3.40131374
41plasma lipoprotein particle remodeling (GO:0034369)3.40131374
42oligosaccharide biosynthetic process (GO:0009312)3.36317077
43O-glycan processing (GO:0016266)3.32344714
44nonribosomal peptide biosynthetic process (GO:0019184)3.31781277
45low-density lipoprotein particle remodeling (GO:0034374)3.31137133
46excretion (GO:0007588)3.30309809
47L-ascorbic acid metabolic process (GO:0019852)3.29968156
48quinone biosynthetic process (GO:1901663)3.29134632
49lipoprotein transport (GO:0042953)3.28695843
50regulation of cGMP biosynthetic process (GO:0030826)3.27923019
51diacylglycerol metabolic process (GO:0046339)3.27233477
52high-density lipoprotein particle remodeling (GO:0034375)3.25515786
53lipoprotein metabolic process (GO:0042157)3.21347538
54digestive system process (GO:0022600)3.21177920
55receptor guanylyl cyclase signaling pathway (GO:0007168)3.21132038
56regulation of systemic arterial blood pressure (GO:0003073)3.21074278
57NADH metabolic process (GO:0006734)3.20712015
58drug transport (GO:0015893)3.16367013
59vitamin biosynthetic process (GO:0009110)3.14288149
60sulfur compound transport (GO:0072348)3.13850896
61sulfation (GO:0051923)3.11595002
62glycerol metabolic process (GO:0006071)3.11240135
63vitamin transport (GO:0051180)3.09716929
64transcytosis (GO:0045056)3.08949923
65plasma lipoprotein particle organization (GO:0071827)3.07132392
66urate metabolic process (GO:0046415)3.07036439
67alkaloid metabolic process (GO:0009820)3.06320433
68digestion (GO:0007586)3.04829411
69hormone catabolic process (GO:0042447)3.02653949
70regulation of cholesterol homeostasis (GO:2000188)3.00317771
71regulation of cholesterol esterification (GO:0010872)2.99189290
72cellular ketone body metabolic process (GO:0046950)2.95827575
73protein-lipid complex assembly (GO:0065005)2.93065692
74* L-fucose catabolic process (GO:0042355)2.92611775
75* fucose catabolic process (GO:0019317)2.92611775
76* L-fucose metabolic process (GO:0042354)2.92611775
77axonemal dynein complex assembly (GO:0070286)2.90961614
78reverse cholesterol transport (GO:0043691)2.90527938
79sodium ion homeostasis (GO:0055078)2.89806474
80cholesterol efflux (GO:0033344)2.89727418
81triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.86311835
82cilium or flagellum-dependent cell motility (GO:0001539)2.86003174
83renal absorption (GO:0070293)2.84340275
84alditol metabolic process (GO:0019400)2.81773867
85regulation of cellular extravasation (GO:0002691)2.81367898
86primary alcohol metabolic process (GO:0034308)2.80854752
87fructose metabolic process (GO:0006000)2.79983428
88proline metabolic process (GO:0006560)2.76660187
89cholesterol homeostasis (GO:0042632)2.76023600
90auditory receptor cell differentiation (GO:0042491)2.75735716
91protein-lipid complex subunit organization (GO:0071825)2.74997491
92peptide hormone processing (GO:0016486)2.74088821
93regulation of memory T cell differentiation (GO:0043380)2.73843448
94complement activation, classical pathway (GO:0006958)2.73310770
95renal system process involved in regulation of blood volume (GO:0001977)2.71696825
96phosphatidylserine acyl-chain remodeling (GO:0036150)2.71436944
97trivalent inorganic anion homeostasis (GO:0072506)2.69690816
98phosphate ion homeostasis (GO:0055062)2.69690816
99sterol homeostasis (GO:0055092)2.69516046
100pyrimidine-containing compound transmembrane transport (GO:0072531)2.69297095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human3.62889445
2VDR_22108803_ChIP-Seq_LS180_Human3.41715941
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.35501711
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.12701699
5ZNF274_21170338_ChIP-Seq_K562_Hela2.83838743
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65822419
7GATA4_25053715_ChIP-Seq_YYC3_Human2.57616702
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.50075663
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.47017273
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.39260837
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.36998567
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.33447179
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.17488422
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.14290041
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.02465600
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84937635
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80078910
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.73856691
19GATA6_25053715_ChIP-Seq_YYC3_Human1.72175532
20BCAT_22108803_ChIP-Seq_LS180_Human1.70782135
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70764070
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.70511864
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68033635
24DROSHA_22980978_ChIP-Seq_HELA_Human1.59557231
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58625487
26CDX2_22108803_ChIP-Seq_LS180_Human1.57565789
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.57554107
28SOX2_20726797_ChIP-Seq_SW620_Human1.55254551
29ETV2_25802403_ChIP-Seq_MESCs_Mouse1.55139488
30PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.54611328
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.53509462
32CEBPB_22108803_ChIP-Seq_LS180_Human1.41592652
33* TAF2_19829295_ChIP-Seq_ESCs_Human1.41275531
34FOXA1_25329375_ChIP-Seq_VCAP_Human1.39808558
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39808558
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39063381
37EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.39017948
38NANOG_20526341_ChIP-Seq_ESCs_Human1.38898044
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.38761651
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37818932
41AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37064944
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32542342
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31867062
44MYC_19829295_ChIP-Seq_ESCs_Human1.31147621
45AR_20517297_ChIP-Seq_VCAP_Human1.30816857
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30280819
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29062835
48ERA_21632823_ChIP-Seq_H3396_Human1.28538649
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26608163
50NCOR_22424771_ChIP-Seq_293T_Human1.26236616
51P53_21459846_ChIP-Seq_SAOS-2_Human1.24975063
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.24061209
53OCT4_20526341_ChIP-Seq_ESCs_Human1.22998740
54KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22152702
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21942699
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21268695
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.20823547
58* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20171025
59FOXH1_21741376_ChIP-Seq_ESCs_Human1.19485909
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18777454
61TCF4_22108803_ChIP-Seq_LS180_Human1.18324536
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.18289997
63IGF1R_20145208_ChIP-Seq_DFB_Human1.15279977
64FOXA1_25552417_ChIP-Seq_VCAP_Human1.14499329
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.14475133
66FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13350752
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13141538
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.11970541
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11740115
70GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.09562553
71STAT1_20625510_ChIP-Seq_HELA_Human1.09130838
72* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08629607
73* E2F1_20622854_ChIP-Seq_HELA_Human1.08184647
74ETV1_20927104_ChIP-Seq_GIST48_Human1.07301356
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06377987
76NANOG_19829295_ChIP-Seq_ESCs_Human1.04658446
77SOX2_19829295_ChIP-Seq_ESCs_Human1.04658446
78HOXB7_26014856_ChIP-Seq_BT474_Human1.04578222
79RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04409710
80RAC3_21632823_ChIP-Seq_H3396_Human1.04145984
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03457201
82ER_23166858_ChIP-Seq_MCF-7_Human1.02689499
83RBPJ_21746931_ChIP-Seq_IB4_Human1.02028849
84PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99432947
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99164283
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98087550
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97795262
88* BCL6_27268052_Chip-Seq_Bcells_Human0.97550487
89CTCF_20526341_ChIP-Seq_ESCs_Human0.97080513
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96288953
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95607410
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94459150
93PHF8_20622854_ChIP-Seq_HELA_Human0.93924744
94P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93427801
95SA1_27219007_Chip-Seq_Bcells_Human0.92705396
96P300_27268052_Chip-Seq_Bcells_Human0.91502820
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91058285
98* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91002567
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.90579331
100CBX2_22325352_ChIP-Seq_293T-Rex_Human0.86831872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.29980298
2MP0002139_abnormal_hepatobiliary_system5.23724901
3MP0005085_abnormal_gallbladder_physiolo4.52818293
4MP0004043_abnormal_pH_regulation4.06360626
5MP0005365_abnormal_bile_salt3.94070532
6MP0001666_abnormal_nutrient_absorption3.87164727
7MP0008875_abnormal_xenobiotic_pharmacok3.87013537
8MP0003195_calcinosis3.24888088
9MP0010234_abnormal_vibrissa_follicle2.90920582
10MP0003252_abnormal_bile_duct2.89038996
11MP0004019_abnormal_vitamin_homeostasis2.84526473
12MP0002876_abnormal_thyroid_physiology2.55729759
13MP0010329_abnormal_lipoprotein_level2.54156320
14MP0003183_abnormal_peptide_metabolism2.36540979
15MP0002138_abnormal_hepatobiliary_system2.32682052
16MP0005332_abnormal_amino_acid2.27631768
17MP0004147_increased_porphyrin_level2.22537845
18MP0010155_abnormal_intestine_physiology2.15067010
19MP0004264_abnormal_extraembryonic_tissu2.07606976
20MP0000566_synostosis1.99046335
21MP0003866_abnormal_defecation1.94685090
22MP0001765_abnormal_ion_homeostasis1.90802675
23MP0009643_abnormal_urine_homeostasis1.87651294
24MP0005636_abnormal_mineral_homeostasis1.87175585
25MP0009840_abnormal_foam_cell1.67957985
26MP0001764_abnormal_homeostasis1.64486410
27MP0001664_abnormal_digestion1.63664441
28MP0001873_stomach_inflammation1.51645277
29MP0008872_abnormal_physiological_respon1.44329903
30MP0001501_abnormal_sleep_pattern1.37002641
31MP0002118_abnormal_lipid_homeostasis1.36702601
32MP0001756_abnormal_urination1.35548063
33MP0003868_abnormal_feces_composition1.32641189
34MP0001663_abnormal_digestive_system1.31493165
35MP0003718_maternal_effect1.29109730
36MP0002136_abnormal_kidney_physiology1.26744793
37MP0002102_abnormal_ear_morphology1.26566462
38MP0001485_abnormal_pinna_reflex1.19970117
39MP0003806_abnormal_nucleotide_metabolis1.16456641
40MP0000538_abnormal_urinary_bladder1.14552235
41MP0002098_abnormal_vibrissa_morphology1.06114950
42MP0004782_abnormal_surfactant_physiolog1.06047558
43MP0005319_abnormal_enzyme/_coenzyme1.05225938
44MP0003879_abnormal_hair_cell1.04470261
45MP0009785_altered_susceptibility_to1.03107928
46MP0000609_abnormal_liver_physiology1.02656782
47MP0009379_abnormal_foot_pigmentation1.01960288
48MP0000477_abnormal_intestine_morphology1.01678081
49MP0005381_digestive/alimentary_phenotyp0.97825263
50MP0001986_abnormal_taste_sensitivity0.92747146
51MP0000678_abnormal_parathyroid_gland0.92057753
52MP0005551_abnormal_eye_electrophysiolog0.91860539
53MP0000230_abnormal_systemic_arterial0.88835063
54MP0000465_gastrointestinal_hemorrhage0.87289051
55MP0010678_abnormal_skin_adnexa0.86516411
56MP0002909_abnormal_adrenal_gland0.85802732
57MP0005448_abnormal_energy_balance0.85074772
58MP0009780_abnormal_chondrocyte_physiolo0.84538550
59MP0005083_abnormal_biliary_tract0.82550481
60MP0009642_abnormal_blood_homeostasis0.80785039
61MP0004885_abnormal_endolymph0.78682416
62MP0003878_abnormal_ear_physiology0.75031298
63MP0005377_hearing/vestibular/ear_phenot0.75031298
64MP0001845_abnormal_inflammatory_respons0.70298170
65MP0005670_abnormal_white_adipose0.69079743
66MP0005166_decreased_susceptibility_to0.69015077
67MP0005645_abnormal_hypothalamus_physiol0.68523446
68MP0001835_abnormal_antigen_presentation0.68121446
69MP0008469_abnormal_protein_level0.67752633
70MP0003953_abnormal_hormone_level0.66164018
71MP0003011_delayed_dark_adaptation0.65934883
72MP0005584_abnormal_enzyme/coenzyme_acti0.63990447
73MP0005395_other_phenotype0.61594275
74MP0000427_abnormal_hair_cycle0.61436363
75MP0005387_immune_system_phenotype0.61187655
76MP0001790_abnormal_immune_system0.61187655
77MP0001188_hyperpigmentation0.60559571
78MP0000467_abnormal_esophagus_morphology0.59951451
79MP0002132_abnormal_respiratory_system0.59417114
80MP0002078_abnormal_glucose_homeostasis0.59095347
81MP0000490_abnormal_crypts_of0.58644959
82MP0009764_decreased_sensitivity_to0.58531206
83MP0008775_abnormal_heart_ventricle0.58387719
84MP0000383_abnormal_hair_follicle0.57483886
85MP0001984_abnormal_olfaction0.53535079
86MP0005535_abnormal_body_temperature0.52676307
87MP0004742_abnormal_vestibular_system0.50335206
88MP0003638_abnormal_response/metabolism_0.45418309
89MP0005410_abnormal_fertilization0.45352934
90MP0005310_abnormal_salivary_gland0.45188654
91MP0000470_abnormal_stomach_morphology0.44828364
92MP0002822_catalepsy0.44056217
93MP0001270_distended_abdomen0.44029384
94MP0005025_abnormal_response_to0.43487810
95MP0004270_analgesia0.43328887
96MP0000685_abnormal_immune_system0.43260265
97MP0005671_abnormal_response_to0.43031660
98MP0002135_abnormal_kidney_morphology0.42977301
99MP0002069_abnormal_eating/drinking_beha0.42548729
100MP0002089_abnormal_postnatal_growth/wei0.42371911

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)6.11836491
2Hyperactive renin-angiotensin system (HP:0000841)5.10625560
3Decreased circulating renin level (HP:0003351)4.68591073
4Hydroxyprolinuria (HP:0003080)4.52061340
5Abnormality of proline metabolism (HP:0010907)4.52061340
6Abnormality of renin-angiotensin system (HP:0000847)4.19033313
7Hypobetalipoproteinemia (HP:0003563)4.12325381
8Alkalosis (HP:0001948)3.83762908
9Metabolic alkalosis (HP:0200114)3.79488446
10Malnutrition (HP:0004395)3.78642751
11Abnormality of the vitamin B12 metabolism (HP:0004341)3.45866022
12Hyperglycinuria (HP:0003108)3.43027997
13Abnormality of vitamin B metabolism (HP:0004340)3.35668080
14Abnormality of serine family amino acid metabolism (HP:0010894)3.25501209
15Abnormality of glycine metabolism (HP:0010895)3.25501209
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.25165762
17Abnormality of chloride homeostasis (HP:0011422)3.24433786
18Hyperaldosteronism (HP:0000859)3.09521091
19Congenital sensorineural hearing impairment (HP:0008527)3.07690129
20Widely patent fontanelles and sutures (HP:0004492)3.05863106
21Glycosuria (HP:0003076)3.03712594
22Abnormality of urine glucose concentration (HP:0011016)3.03712594
23Chronic diarrhea (HP:0002028)3.02840387
24Fat malabsorption (HP:0002630)3.02651137
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.94432946
26Absent/shortened dynein arms (HP:0200106)2.94432946
27Abnormality of vitamin metabolism (HP:0100508)2.91562975
28Systemic lupus erythematosus (HP:0002725)2.90975556
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.85887063
30Chronic bronchitis (HP:0004469)2.81030751
31Hemorrhage of the eye (HP:0011885)2.78571025
32Abnormal respiratory epithelium morphology (HP:0012253)2.78089073
33Abnormal respiratory motile cilium morphology (HP:0005938)2.78089073
34Conjugated hyperbilirubinemia (HP:0002908)2.76051312
35Pigmentary retinal degeneration (HP:0001146)2.73522174
36Abnormality of magnesium homeostasis (HP:0004921)2.67240208
37Xanthomatosis (HP:0000991)2.65040774
38Confusion (HP:0001289)2.65018277
39Proximal tubulopathy (HP:0000114)2.62475612
40Ileus (HP:0002595)2.62176386
41Delayed CNS myelination (HP:0002188)2.59755078
42Abnormal respiratory motile cilium physiology (HP:0012261)2.55549390
43Abnormal ciliary motility (HP:0012262)2.54186925
44Potter facies (HP:0002009)2.51120364
45Facial shape deformation (HP:0011334)2.51120364
46Prolonged partial thromboplastin time (HP:0003645)2.45163997
47Abnormality of the renal cortex (HP:0011035)2.44684455
48Complement deficiency (HP:0004431)2.44170370
49Hypomagnesemia (HP:0002917)2.39778293
50Hypokalemia (HP:0002900)2.38597464
51Glomerulonephritis (HP:0000099)2.31503309
52Renal salt wasting (HP:0000127)2.30281356
53Abnormality of renal excretion (HP:0011036)2.29711013
54Hyperglycinemia (HP:0002154)2.27834925
55Gout (HP:0001997)2.26907893
56Hyperammonemia (HP:0001987)2.25543874
57Acanthocytosis (HP:0001927)2.24876874
58Metabolic acidosis (HP:0001942)2.24604017
59Tubular atrophy (HP:0000092)2.23579179
60Intrahepatic cholestasis (HP:0001406)2.21939521
61Deep venous thrombosis (HP:0002625)2.21621383
62Epidermoid cyst (HP:0200040)2.21547683
63Bronchiectasis (HP:0002110)2.20637244
64Renal cortical cysts (HP:0000803)2.19916160
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17302351
66Dicarboxylic aciduria (HP:0003215)2.17302351
67Rhinitis (HP:0012384)2.15860695
68Pancreatic cysts (HP:0001737)2.15121522
69Generalized aminoaciduria (HP:0002909)2.15050970
70Abnormal urine output (HP:0012590)2.13570146
71Abnormality of potassium homeostasis (HP:0011042)2.13372713
72Increased purine levels (HP:0004368)2.12386133
73Hyperuricemia (HP:0002149)2.12386133
74Hypothermia (HP:0002045)2.11724280
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10723707
76Ketosis (HP:0001946)2.10454940
77Abnormality of purine metabolism (HP:0004352)2.08622595
78Nausea (HP:0002018)2.06770436
79Focal segmental glomerulosclerosis (HP:0000097)2.03268875
80Glomerulosclerosis (HP:0000096)2.01413577
81Ketoacidosis (HP:0001993)1.97317907
82Lethargy (HP:0001254)1.95265659
83Abnormality of nucleobase metabolism (HP:0010932)1.92496699
84Nephrolithiasis (HP:0000787)1.90928945
85Cerebral palsy (HP:0100021)1.90754388
86Hypophosphatemic rickets (HP:0004912)1.87601547
87Steatorrhea (HP:0002570)1.86509372
88Hypolipoproteinemia (HP:0010981)1.86219558
89Abnormality of serum amino acid levels (HP:0003112)1.83706681
90Hyperkalemia (HP:0002153)1.83402285
91Nephritis (HP:0000123)1.82806260
92Hypoalbuminemia (HP:0003073)1.82752116
93Abnormal albumin level (HP:0012116)1.82752116
94Decreased central vision (HP:0007663)1.81464128
95Vascular calcification (HP:0004934)1.81297155
96Pancreatitis (HP:0001733)1.80333581
97Pustule (HP:0200039)1.80227444
98Cystic liver disease (HP:0006706)1.79377594
99True hermaphroditism (HP:0010459)1.79092228
100Hypokalemic alkalosis (HP:0001949)1.78444152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.78353846
2WNK44.39640759
3MST1R3.80082216
4FRK3.69510542
5OXSR13.40313236
6EPHA23.26931556
7STK392.91832916
8ADRBK22.62989526
9MAP4K22.55747230
10WNK32.42024865
11PIK3CA2.29589368
12GRK12.23741850
13ERN12.22374186
14NME12.14233762
15BMPR1B2.07520868
16MAPKAPK31.93621371
17MET1.80951496
18MST41.68067516
19PINK11.57367531
20FGFR41.48548674
21PRKG21.47479733
22EPHA31.46608570
23MAP2K61.45259908
24FGFR31.42880429
25FER1.34100556
26TXK1.31140475
27TLK11.25371614
28MAPK151.21623007
29ZAK1.21215588
30LMTK21.20871005
31CDK191.07997613
32BCR1.07860537
33PRKAA21.06756150
34MAP4K11.04414991
35MAP3K21.01653698
36STK161.01000696
37TAOK30.96662955
38INSRR0.94586581
39ITK0.94250880
40MATK0.92317748
41RIPK10.88406597
42ERBB20.83472884
43PRKCI0.82858858
44TNIK0.80046562
45EPHA40.79012169
46NUAK10.75242691
47EIF2AK30.74112907
48TIE10.70068388
49ADRBK10.68759656
50PRKCZ0.67418033
51MAPKAPK50.67314456
52PTK60.65936464
53CASK0.65148658
54WNK10.63679480
55GRK60.63587390
56PRKCE0.62700482
57NLK0.60639513
58PAK30.59410540
59PRKCA0.58840931
60AKT30.58660854
61IRAK10.56975933
62TEC0.53918016
63MAP2K20.53266411
64DAPK20.52735017
65MAP3K40.51446761
66PHKG10.50450000
67PHKG20.50450000
68IGF1R0.49903690
69PDPK10.49345888
70PRKACG0.48415417
71PDK20.47814104
72CSNK1A10.47792367
73PDK10.47414920
74MAP3K70.47292168
75BCKDK0.45610180
76STK240.45103436
77FGFR20.42548220
78MAPK110.39898243
79FLT30.39245858
80MAP3K120.38938154
81PRKACA0.37834271
82IKBKB0.37790296
83CAMK2D0.37577874
84CHUK0.37449439
85TRIM280.36304442
86PRKCQ0.35606545
87DYRK20.35406121
88PRKAA10.35396863
89EPHB10.33141059
90CSF1R0.31405560
91PRKCD0.30812125
92TBK10.30572610
93MAP2K70.30350264
94TESK20.29882626
95ERBB30.29660425
96PRKCG0.29483266
97SRC0.28664731
98MUSK0.27848611
99SGK10.27588152
100MAPK130.26417741

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.02905584
2Fat digestion and absorption_Homo sapiens_hsa049753.29292216
3Caffeine metabolism_Homo sapiens_hsa002323.11618780
4Histidine metabolism_Homo sapiens_hsa003402.70198543
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68098431
6Vitamin digestion and absorption_Homo sapiens_hsa049772.67790858
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.34320831
8Chemical carcinogenesis_Homo sapiens_hsa052042.33939865
9Retinol metabolism_Homo sapiens_hsa008302.27799134
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22552806
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.21164069
12Linoleic acid metabolism_Homo sapiens_hsa005912.18181391
13Sulfur metabolism_Homo sapiens_hsa009202.12257324
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.07292509
15Arginine biosynthesis_Homo sapiens_hsa002202.06294276
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04107505
17* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.98929321
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97753044
19Renin-angiotensin system_Homo sapiens_hsa046141.95780147
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.95100534
21Fatty acid degradation_Homo sapiens_hsa000711.80250426
22Mineral absorption_Homo sapiens_hsa049781.79698379
23Tryptophan metabolism_Homo sapiens_hsa003801.75654074
24Starch and sucrose metabolism_Homo sapiens_hsa005001.72499372
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72386918
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.64565388
27Nitrogen metabolism_Homo sapiens_hsa009101.61261218
28PPAR signaling pathway_Homo sapiens_hsa033201.51151741
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.49732450
30Arginine and proline metabolism_Homo sapiens_hsa003301.48266275
31Asthma_Homo sapiens_hsa053101.43534081
32Butanoate metabolism_Homo sapiens_hsa006501.41538302
33Arachidonic acid metabolism_Homo sapiens_hsa005901.41282124
34Bile secretion_Homo sapiens_hsa049761.37073447
35Phenylalanine metabolism_Homo sapiens_hsa003601.36056909
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.35531235
37Fructose and mannose metabolism_Homo sapiens_hsa000511.32868259
38Ether lipid metabolism_Homo sapiens_hsa005651.30590360
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27656319
40Glycerolipid metabolism_Homo sapiens_hsa005611.27277287
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25758177
42Peroxisome_Homo sapiens_hsa041461.24943294
43Complement and coagulation cascades_Homo sapiens_hsa046101.22116741
44Protein digestion and absorption_Homo sapiens_hsa049741.11338737
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10411385
46Staphylococcus aureus infection_Homo sapiens_hsa051501.09551515
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08724897
48Propanoate metabolism_Homo sapiens_hsa006401.06043321
49Allograft rejection_Homo sapiens_hsa053301.04690590
50Tyrosine metabolism_Homo sapiens_hsa003501.04163579
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03067515
52ABC transporters_Homo sapiens_hsa020101.01177351
53Type I diabetes mellitus_Homo sapiens_hsa049400.96676088
54Autoimmune thyroid disease_Homo sapiens_hsa053200.92609406
55Galactose metabolism_Homo sapiens_hsa000520.89665011
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89601970
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86756329
58beta-Alanine metabolism_Homo sapiens_hsa004100.86151161
59Glutathione metabolism_Homo sapiens_hsa004800.86135845
60Fatty acid metabolism_Homo sapiens_hsa012120.82595949
61Fatty acid biosynthesis_Homo sapiens_hsa000610.81347670
62Graft-versus-host disease_Homo sapiens_hsa053320.77273279
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72565771
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72437502
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67635992
66Pyruvate metabolism_Homo sapiens_hsa006200.64534902
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64206021
68Sphingolipid metabolism_Homo sapiens_hsa006000.58266275
69Phototransduction_Homo sapiens_hsa047440.56391478
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54910063
71* Metabolic pathways_Homo sapiens_hsa011000.54709657
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50555659
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49320823
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46737312
75Pancreatic secretion_Homo sapiens_hsa049720.46737087
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45383543
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.44467310
78Selenocompound metabolism_Homo sapiens_hsa004500.43448218
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36686231
80Sulfur relay system_Homo sapiens_hsa041220.35347053
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33091822
82Thyroid hormone synthesis_Homo sapiens_hsa049180.32759878
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31924076
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28843820
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.26394925
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.23498829
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23141590
88Taste transduction_Homo sapiens_hsa047420.20868632
89Fatty acid elongation_Homo sapiens_hsa000620.20577645
90Antigen processing and presentation_Homo sapiens_hsa046120.20217359
91Ovarian steroidogenesis_Homo sapiens_hsa049130.18472779
92Pertussis_Homo sapiens_hsa051330.18400105
93Salivary secretion_Homo sapiens_hsa049700.17648184
94Steroid biosynthesis_Homo sapiens_hsa001000.17471209
95Insulin resistance_Homo sapiens_hsa049310.17245919
96Other glycan degradation_Homo sapiens_hsa005110.16758226
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15882748
98Rheumatoid arthritis_Homo sapiens_hsa053230.15435427
99Insulin secretion_Homo sapiens_hsa049110.14219086
100Serotonergic synapse_Homo sapiens_hsa047260.10470622

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