FUZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.54094647
2cilium movement (GO:0003341)9.24574693
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.70508810
4central nervous system myelination (GO:0022010)7.33685050
5axon ensheathment in central nervous system (GO:0032291)7.33685050
6axoneme assembly (GO:0035082)6.60730768
7left/right pattern formation (GO:0060972)6.17718300
8regulation of cilium movement (GO:0003352)6.01865547
9viral transcription (GO:0019083)5.04911347
10microtubule bundle formation (GO:0001578)4.80030078
11protein polyglutamylation (GO:0018095)4.68135132
12translational termination (GO:0006415)4.67855128
13ventricular system development (GO:0021591)4.64245191
14ribosomal small subunit assembly (GO:0000028)4.55457807
15sperm capacitation (GO:0048240)4.50168785
16regulation of microtubule-based movement (GO:0060632)4.49725807
17microtubule severing (GO:0051013)4.47926400
18cotranslational protein targeting to membrane (GO:0006613)4.22136081
19left/right axis specification (GO:0070986)4.21671495
20protein targeting to ER (GO:0045047)4.19238743
21DNA deamination (GO:0045006)4.15047043
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.14465554
23sperm motility (GO:0030317)4.05795617
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.05752338
25negative regulation of T cell differentiation in thymus (GO:0033085)4.04053202
26lung epithelium development (GO:0060428)4.03414196
27protein localization to endoplasmic reticulum (GO:0070972)3.98008226
28response to methylmercury (GO:0051597)3.89661025
29intraciliary transport (GO:0042073)3.83903624
30negative regulation of inclusion body assembly (GO:0090084)3.77655759
31neuronal action potential propagation (GO:0019227)3.74849282
32ensheathment of neurons (GO:0007272)3.72761940
33axon ensheathment (GO:0008366)3.72761940
34response to xenobiotic stimulus (GO:0009410)3.69553231
35creatine metabolic process (GO:0006600)3.69445264
36translational elongation (GO:0006414)3.69216432
37myelination (GO:0042552)3.61951690
38behavioral response to nicotine (GO:0035095)3.59497656
39cellular protein complex disassembly (GO:0043624)3.59272627
40ribosomal small subunit biogenesis (GO:0042274)3.58969173
41negative regulation of erythrocyte differentiation (GO:0045647)3.57789072
42centriole assembly (GO:0098534)3.52978097
43heme biosynthetic process (GO:0006783)3.52025144
44establishment of mitochondrion localization (GO:0051654)3.51076587
45* cilium organization (GO:0044782)3.47199134
46acrosome reaction (GO:0007340)3.44385869
47viral life cycle (GO:0019058)3.40053432
48* cilium assembly (GO:0042384)3.37955410
49protein localization to cilium (GO:0061512)3.33224627
50neuronal ion channel clustering (GO:0045161)3.32447474
51protein insertion into membrane (GO:0051205)3.31683401
52microtubule depolymerization (GO:0007019)3.31256182
53establishment of apical/basal cell polarity (GO:0035089)3.28827226
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27968164
55establishment or maintenance of monopolar cell polarity (GO:0061339)3.27375765
56establishment of monopolar cell polarity (GO:0061162)3.27375765
57protein complex disassembly (GO:0043241)3.26942125
58positive regulation of oligodendrocyte differentiation (GO:0048714)3.22706047
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.10685575
60negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10419659
61photoreceptor cell differentiation (GO:0046530)3.09413308
62eye photoreceptor cell differentiation (GO:0001754)3.09413308
63spermatid development (GO:0007286)3.06531526
64regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06153322
65microtubule polymerization or depolymerization (GO:0031109)3.02530518
66tolerance induction (GO:0002507)2.99114211
67macromolecular complex disassembly (GO:0032984)2.97434242
68regulation of inclusion body assembly (GO:0090083)2.96732656
69microtubule-based movement (GO:0007018)2.94705808
70L-serine transport (GO:0015825)2.93725387
71protein targeting to membrane (GO:0006612)2.91097765
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90836919
73antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90836919
74one-carbon compound transport (GO:0019755)2.88846162
75oligodendrocyte differentiation (GO:0048709)2.86271150
76negative regulation of purine nucleotide catabolic process (GO:0033122)2.86242705
77negative regulation of GTP catabolic process (GO:0033125)2.83162703
78negative regulation of GTPase activity (GO:0034260)2.83162703
79negative regulation of nucleotide catabolic process (GO:0030812)2.82581267
80nucleoside diphosphate phosphorylation (GO:0006165)2.76670945
81serine transport (GO:0032329)2.75889511
82negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.74668897
83pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74233005
84GTP biosynthetic process (GO:0006183)2.70689464
85porphyrin-containing compound biosynthetic process (GO:0006779)2.69968160
86oxygen transport (GO:0015671)2.69763573
87proline biosynthetic process (GO:0006561)2.69584099
88* cellular component assembly involved in morphogenesis (GO:0010927)2.69058951
89cytoplasmic microtubule organization (GO:0031122)2.68959869
90camera-type eye morphogenesis (GO:0048593)2.67232362
91cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.67230421
92tooth mineralization (GO:0034505)2.66701389
93translational initiation (GO:0006413)2.66644024
94establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.64105083
95mitochondrion transport along microtubule (GO:0047497)2.64105083
96negative regulation of DNA-templated transcription, elongation (GO:0032785)2.61280894
97mitochondrion degradation (GO:0000422)2.60513720
98* regulation of cilium assembly (GO:1902017)2.59791730
99regulation of interleukin-5 production (GO:0032674)2.59760136
100cranial nerve morphogenesis (GO:0021602)2.59738447
101regulation of interleukin-13 production (GO:0032656)2.59706075
102positive regulation of synapse maturation (GO:0090129)2.59349886
103short-term memory (GO:0007614)2.59057770
104regulation of amyloid precursor protein catabolic process (GO:1902991)2.59029265
105astrocyte differentiation (GO:0048708)2.58984574
106primary alcohol catabolic process (GO:0034310)2.58028823
107regulation of oligodendrocyte differentiation (GO:0048713)2.57425557
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57012677
109thalamus development (GO:0021794)2.56998386
110negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.55808977
111regulation of respiratory system process (GO:0044065)2.55552284
112oxidative demethylation (GO:0070989)2.55508937
113potassium ion homeostasis (GO:0055075)2.54569047
114cellular potassium ion homeostasis (GO:0030007)2.54441859
115regulation of beta-amyloid formation (GO:1902003)2.53771851
116neurotransmitter catabolic process (GO:0042135)2.52699577
117membrane tubulation (GO:0097320)2.52426016
118negative regulation of nucleoside metabolic process (GO:0045978)2.51463111
119regulation of ARF GTPase activity (GO:0032312)2.51164746
120pattern specification involved in kidney development (GO:0061004)2.51094398
121cell migration in hindbrain (GO:0021535)2.50650945
122fatty acid elongation (GO:0030497)2.50391911
123positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.50232058
124myelin maintenance (GO:0043217)2.47106547
125protein palmitoylation (GO:0018345)2.46972326
126positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46768436
127UTP biosynthetic process (GO:0006228)2.44989355
128segment specification (GO:0007379)2.44182003
129spinal cord motor neuron differentiation (GO:0021522)2.43378482
130positive regulation of cellular amine metabolic process (GO:0033240)2.43246100
131adult walking behavior (GO:0007628)2.43241784
132epithelial cilium movement (GO:0003351)2.42722856
133tetrapyrrole biosynthetic process (GO:0033014)2.42691821
134regulation of hydrogen peroxide-induced cell death (GO:1903205)2.42685086
135regulation of vacuole organization (GO:0044088)2.42631278
136Sertoli cell development (GO:0060009)2.42384258
137postsynaptic membrane organization (GO:0001941)2.40915507
138proline metabolic process (GO:0006560)2.40821069
139histone H4 deacetylation (GO:0070933)2.40480170
140metanephric nephron tubule development (GO:0072234)2.40210195
141metanephric tubule development (GO:0072170)2.40210195
142detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.39513057
143detection of temperature stimulus involved in sensory perception (GO:0050961)2.39513057
144antigen processing and presentation of endogenous antigen (GO:0019883)2.39384161
145positive thymic T cell selection (GO:0045059)2.39030231
146response to misfolded protein (GO:0051788)2.38608124
147negative regulation of immunoglobulin mediated immune response (GO:0002890)2.36937449
148negative regulation of B cell mediated immunity (GO:0002713)2.36937449
149vitamin transmembrane transport (GO:0035461)2.36841748
150regulation of germinal center formation (GO:0002634)2.36624357
151receptor clustering (GO:0043113)2.35995713
152maturation of SSU-rRNA (GO:0030490)2.35294962
153activated T cell proliferation (GO:0050798)2.35236548
154endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.34712585
155enteric nervous system development (GO:0048484)2.34463671
156neuron cell-cell adhesion (GO:0007158)2.34418606
157regulation of autophagic vacuole assembly (GO:2000785)2.34297039
158heme metabolic process (GO:0042168)2.33885844
159astrocyte development (GO:0014002)2.33774154
160calcium ion-dependent exocytosis (GO:0017156)2.33295311
161ethanol metabolic process (GO:0006067)2.32883014
162response to dietary excess (GO:0002021)2.32605334
163negative regulation of glycoprotein biosynthetic process (GO:0010561)2.32436683
164* cell projection assembly (GO:0030031)2.31642612
165telencephalon development (GO:0021537)2.31180120
166deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.30365464
167substrate-independent telencephalic tangential migration (GO:0021826)2.29926825
168substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.29926825
169negative regulation of Ras GTPase activity (GO:0034261)2.28615529
170negative regulation of response to reactive oxygen species (GO:1901032)2.27306236
171axonemal dynein complex assembly (GO:0070286)13.1023747
172cilium or flagellum-dependent cell motility (GO:0001539)10.3055757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.04281740
2VDR_21846776_ChIP-Seq_THP-1_Human3.74166791
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.32077116
4LXR_22292898_ChIP-Seq_THP-1_Human2.88348518
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.87414769
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30666499
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29449070
8KDM2B_26808549_Chip-Seq_DND41_Human2.17605630
9SMC4_20622854_ChIP-Seq_HELA_Human2.17185510
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10415673
11YY1_22570637_ChIP-Seq_MALME-3M_Human2.10118327
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.08481678
13* VDR_24763502_ChIP-Seq_THP-1_Human2.07086345
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05758181
15SCL_19346495_ChIP-Seq_HPC-7_Human2.03377737
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.98996347
17* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.86969310
18PHF8_20622854_ChIP-Seq_HELA_Human1.86340860
19SA1_27219007_Chip-Seq_ERYTHROID_Human1.80998184
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80902131
21CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77170605
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76077365
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71887725
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69225914
25TET1_21451524_ChIP-Seq_MESCs_Mouse1.68533705
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68471060
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.68021937
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67143939
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66776662
30* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.64758197
31P68_20966046_ChIP-Seq_HELA_Human1.63793367
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.62132365
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.57245097
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57142707
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57112311
36STAT1_20625510_ChIP-Seq_HELA_Human1.54652631
37MAF_26560356_Chip-Seq_TH2_Human1.54561848
38MYC_22102868_ChIP-Seq_BL_Human1.54380266
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53837939
40RACK7_27058665_Chip-Seq_MCF-7_Human1.53413880
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51502992
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49073653
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.48820030
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48709926
45TP63_22573176_ChIP-Seq_HFKS_Human1.48655546
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48333907
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48121037
48OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.47410784
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47179528
50MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.46179150
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45834452
52* CREB1_26743006_Chip-Seq_LNCaP_Human1.45497554
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45029235
54SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44682466
55CTCF_27219007_Chip-Seq_Bcells_Human1.44345838
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43250483
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42591932
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42265916
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42131082
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41215169
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39732818
62OCT4_19829295_ChIP-Seq_ESCs_Human1.38901603
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38800408
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38800408
65* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.38537947
66* TCF7_22412390_ChIP-Seq_EML_Mouse1.38430065
67SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.37879421
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37450717
69PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36514277
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.35490832
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.34228310
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33730677
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33308247
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33102956
75KDM2B_26808549_Chip-Seq_K562_Human1.32439309
76CTCF_26484167_Chip-Seq_Bcells_Mouse1.31963396
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31827006
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31590745
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.31566013
80* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31472077
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31254735
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29904813
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28625644
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28546463
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.28052623
86CTCF_21964334_ChIP-Seq_BJAB-B_Human1.27990672
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.27656529
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27622897
89UTX_26944678_Chip-Seq_JUKART_Human1.26922656
90ERA_21632823_ChIP-Seq_H3396_Human1.26314556
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25725204
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25649500
93SA1_27219007_Chip-Seq_Bcells_Human1.25449792
94ZNF263_19887448_ChIP-Seq_K562_Human1.25157427
95RAD21_21589869_ChIP-Seq_MESCs_Mouse1.25076481
96* FOXP1_21924763_ChIP-Seq_HESCs_Human1.24198028
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23850061
98* BCL6_27268052_Chip-Seq_Bcells_Human1.23709397
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23670367
100* BCOR_27268052_Chip-Seq_Bcells_Human1.23139724
101MAF_26560356_Chip-Seq_TH1_Human1.22623796
102RARA_24833708_ChIP-Seq_LIVER_Mouse1.22202354
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21515791
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19346111
105ELK3_25401928_ChIP-Seq_HUVEC_Human1.18968278
106CTCF_20526341_ChIP-Seq_ESCs_Human1.18727058
107RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18709325
108RARB_24833708_ChIP-Seq_LIVER_Mouse1.18675971
109P300_27268052_Chip-Seq_Bcells_Human1.18558360
110E2F1_20622854_ChIP-Seq_HELA_Human1.16446179
111* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15740573
112DROSHA_22980978_ChIP-Seq_HELA_Human1.15345578
113REST_21632747_ChIP-Seq_MESCs_Mouse1.14903941
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14551121
115RNF2_27304074_Chip-Seq_ESCs_Mouse1.14403417
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12113956
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11859337
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11416872
119* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11068328
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09748606
121EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09170441
122TP53_22127205_ChIP-Seq_IMR90_Human1.08434675
123CTCF_21964334_Chip-Seq_Bcells_Human1.08211729
124EZH2_22144423_ChIP-Seq_EOC_Human1.07982922
125EED_16625203_ChIP-ChIP_MESCs_Mouse1.07279024
126TAF2_19829295_ChIP-Seq_ESCs_Human1.02920684
127KLF4_19829295_ChIP-Seq_ESCs_Human1.02634361
128TET1_21490601_ChIP-Seq_MESCs_Mouse1.00130935
129SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99430359
130* SPI1_20517297_ChIP-Seq_HL60_Human0.99013572
131* YY1_21170310_ChIP-Seq_MESCs_Mouse0.97972460
132* TP53_23651856_ChIP-Seq_MEFs_Mouse0.96409004
133FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95817012
134SOX2_21211035_ChIP-Seq_LN229_Human0.95816381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.39626370
2MP0005377_hearing/vestibular/ear_phenot3.06407331
3MP0003878_abnormal_ear_physiology3.06407331
4MP0009379_abnormal_foot_pigmentation2.85358606
5MP0008789_abnormal_olfactory_epithelium2.82590235
6MP0003011_delayed_dark_adaptation2.77289916
7MP0000920_abnormal_myelination2.70829815
8MP0002822_catalepsy2.60508066
9MP0004142_abnormal_muscle_tone2.57645252
10MP0006072_abnormal_retinal_apoptosis2.50187512
11MP0004145_abnormal_muscle_electrophysio2.37306367
12MP0005394_taste/olfaction_phenotype2.30817581
13MP0005499_abnormal_olfactory_system2.30817581
14MP0005423_abnormal_somatic_nervous2.23626266
15MP0003329_amyloid_beta_deposits2.21839157
16MP0002132_abnormal_respiratory_system2.20762375
17MP0004043_abnormal_pH_regulation2.20139344
18MP0003303_peritoneal_inflammation2.13538674
19MP0005551_abnormal_eye_electrophysiolog2.12178943
20MP0004742_abnormal_vestibular_system2.06877098
21MP0000751_myopathy2.03669622
22MP0002277_abnormal_respiratory_mucosa2.03370357
23MP0000678_abnormal_parathyroid_gland1.97907340
24MP0008569_lethality_at_weaning1.92964095
25MP0001346_abnormal_lacrimal_gland1.84235803
26MP0005410_abnormal_fertilization1.82849325
27MP0009278_abnormal_bone_marrow1.77123084
28MP0005174_abnormal_tail_pigmentation1.75837573
29MP0000749_muscle_degeneration1.75211444
30MP0002272_abnormal_nervous_system1.74199234
31MP0003646_muscle_fatigue1.74047913
32MP0003634_abnormal_glial_cell1.72359962
33MP0002064_seizures1.69711237
34MP0003656_abnormal_erythrocyte_physiolo1.64451128
35MP0001486_abnormal_startle_reflex1.64437837
36MP0004885_abnormal_endolymph1.64255100
37MP0005409_darkened_coat_color1.59264787
38MP0002653_abnormal_ependyma_morphology1.58352050
39MP0008875_abnormal_xenobiotic_pharmacok1.58105446
40MP0005253_abnormal_eye_physiology1.56287521
41MP0000747_muscle_weakness1.54673114
42MP0000778_abnormal_nervous_system1.54258814
43MP0000462_abnormal_digestive_system1.53228325
44MP0000049_abnormal_middle_ear1.49280516
45MP0000003_abnormal_adipose_tissue1.48961945
46MP0002735_abnormal_chemical_nociception1.48772323
47MP0002229_neurodegeneration1.48355065
48MP0002734_abnormal_mechanical_nocicepti1.47168650
49MP0002909_abnormal_adrenal_gland1.46281220
50* MP0000955_abnormal_spinal_cord1.43959461
51MP0003137_abnormal_impulse_conducting1.41992592
52MP0003879_abnormal_hair_cell1.41124282
53MP0000685_abnormal_immune_system1.41059098
54MP0003635_abnormal_synaptic_transmissio1.39929272
55MP0005670_abnormal_white_adipose1.39208836
56MP0009046_muscle_twitch1.38314890
57MP0005623_abnormal_meninges_morphology1.38026807
58MP0004130_abnormal_muscle_cell1.35128925
59MP0001905_abnormal_dopamine_level1.33193122
60MP0002837_dystrophic_cardiac_calcinosis1.31073034
61MP0003698_abnormal_male_reproductive1.30796279
62MP0003866_abnormal_defecation1.30110378
63MP0005381_digestive/alimentary_phenotyp1.29944509
64MP0002067_abnormal_sensory_capabilities1.29452077
65MP0000026_abnormal_inner_ear1.29160954
66MP0002733_abnormal_thermal_nociception1.28866563
67MP0003787_abnormal_imprinting1.28715180
68MP0001485_abnormal_pinna_reflex1.28624731
69MP0001968_abnormal_touch/_nociception1.26503619
70* MP0002882_abnormal_neuron_morphology1.25180889
71MP0001529_abnormal_vocalization1.23993977
72MP0005375_adipose_tissue_phenotype1.23833333
73MP0005646_abnormal_pituitary_gland1.22300577
74MP0001970_abnormal_pain_threshold1.21778478
75MP0000013_abnormal_adipose_tissue1.21595003
76MP0004859_abnormal_synaptic_plasticity1.20888839
77MP0004381_abnormal_hair_follicle1.20804963
78MP0005645_abnormal_hypothalamus_physiol1.18988233
79MP0001984_abnormal_olfaction1.17856562
80MP0000681_abnormal_thyroid_gland1.17328897
81MP0005075_abnormal_melanosome_morpholog1.17188743
82MP0009840_abnormal_foam_cell1.17023831
83MP0004133_heterotaxia1.16666933
84MP0001188_hyperpigmentation1.15584479
85MP0000631_abnormal_neuroendocrine_gland1.15122131
86MP0006292_abnormal_olfactory_placode1.14776483
87MP0001348_abnormal_lacrimal_gland1.13880736
88MP0010030_abnormal_orbit_morphology1.13657109
89MP0003633_abnormal_nervous_system1.12978801
90MP0002249_abnormal_larynx_morphology1.11490187
91MP0002572_abnormal_emotion/affect_behav1.10308812
92MP0006036_abnormal_mitochondrial_physio1.09537725
93MP0009745_abnormal_behavioral_response1.07259767
94MP0001963_abnormal_hearing_physiology1.06339965
95MP0002752_abnormal_somatic_nervous1.05817583
96MP0006276_abnormal_autonomic_nervous1.05621138
97MP0005195_abnormal_posterior_eye1.04688537
98MP0005379_endocrine/exocrine_gland_phen1.03798365
99MP0004233_abnormal_muscle_weight1.02158341
100MP0003942_abnormal_urinary_system1.00896806
101MP0000467_abnormal_esophagus_morphology1.00444382
102MP0003172_abnormal_lysosome_physiology0.99923289
103MP0003136_yellow_coat_color0.99310402
104MP0002089_abnormal_postnatal_growth/wei0.98935122
105MP0001663_abnormal_digestive_system0.98795390
106MP0002066_abnormal_motor_capabilities/c0.97982004
107MP0001765_abnormal_ion_homeostasis0.97627500
108MP0004270_analgesia0.96853034
109MP0003300_gastrointestinal_ulcer0.94332776
110MP0004036_abnormal_muscle_relaxation0.91773307
111MP0000759_abnormal_skeletal_muscle0.91014793
112MP0001502_abnormal_circadian_rhythm0.89713718
113MP0000566_synostosis0.89579970
114MP0005248_abnormal_Harderian_gland0.89189751
115MP0002638_abnormal_pupillary_reflex0.89186627
116MP0005083_abnormal_biliary_tract0.87952841
117MP0003938_abnormal_ear_development0.86345080
118MP0000604_amyloidosis0.85975504
119MP0002557_abnormal_social/conspecific_i0.85972859
120MP0003283_abnormal_digestive_organ0.85915920
121MP0001929_abnormal_gametogenesis0.85498774
122* MP0002152_abnormal_brain_morphology0.84107988
123MP0002269_muscular_atrophy0.82436999
124MP0000465_gastrointestinal_hemorrhage0.82183513
125MP0005220_abnormal_exocrine_pancreas0.81562598
126MP0009053_abnormal_anal_canal0.81436981
127MP0001664_abnormal_digestion0.81096899
128MP0003690_abnormal_glial_cell0.80487075
129MP0003959_abnormal_lean_body0.77880765
130MP0001944_abnormal_pancreas_morphology0.76769587
131MP0005330_cardiomyopathy0.76176716
132MP0001986_abnormal_taste_sensitivity0.75601137
133* MP0005391_vision/eye_phenotype0.74037162
134MP0008874_decreased_physiological_sensi0.73825795
135MP0002161_abnormal_fertility/fecundity0.73004196
136MP0001270_distended_abdomen0.72832071
137MP0002932_abnormal_joint_morphology0.72516631
138MP0002063_abnormal_learning/memory/cond0.71892110
139* MP0003861_abnormal_nervous_system0.71732127
140MP0004811_abnormal_neuron_physiology0.70552135
141MP0000750_abnormal_muscle_regeneration0.70373789
142MP0001440_abnormal_grooming_behavior0.70271100
143MP0002106_abnormal_muscle_physiology0.69408692
144MP0003631_nervous_system_phenotype0.69244002
145MP0002116_abnormal_craniofacial_bone0.68346918
146MP0008260_abnormal_autophagy0.66484428
147MP0002160_abnormal_reproductive_system0.65995981
148MP0003123_paternal_imprinting0.65783625
149MP0002876_abnormal_thyroid_physiology0.64005411

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.76598538
2Abnormal respiratory motile cilium morphology (HP:0005938)9.48675464
3Abnormal respiratory epithelium morphology (HP:0012253)9.48675464
4Abnormal respiratory motile cilium physiology (HP:0012261)9.07920436
5Abnormal ciliary motility (HP:0012262)8.87985350
6Absent/shortened dynein arms (HP:0200106)8.31985945
7Dynein arm defect of respiratory motile cilia (HP:0012255)8.31985945
8Rhinitis (HP:0012384)7.70147477
9Chronic bronchitis (HP:0004469)5.75765186
10Bronchiectasis (HP:0002110)5.38868240
11Megalencephaly (HP:0001355)4.79401267
12Neurofibrillary tangles (HP:0002185)4.33994237
13Concave nail (HP:0001598)3.69823681
14Atelectasis (HP:0100750)3.62791978
15Chronic sinusitis (HP:0011109)3.49675983
16Infertility (HP:0000789)3.41347870
17Occipital encephalocele (HP:0002085)3.39656800
18Cerebral inclusion bodies (HP:0100314)3.39271115
19Pancreatic fibrosis (HP:0100732)3.30952496
20Split foot (HP:0001839)3.28704688
21Recurrent sinusitis (HP:0011108)3.28357210
22Retinal dysplasia (HP:0007973)3.20571978
23Alacrima (HP:0000522)3.18721880
24Nephronophthisis (HP:0000090)3.12103144
25Male infertility (HP:0003251)3.07411584
26Recurrent otitis media (HP:0000403)3.06643409
27Chronic otitis media (HP:0000389)2.99452608
28True hermaphroditism (HP:0010459)2.97104262
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.91996582
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.82462519
31Type II lissencephaly (HP:0007260)2.77926840
32Nasal polyposis (HP:0100582)2.77831899
33Diaphragmatic weakness (HP:0009113)2.76975875
34Muscle hypertrophy of the lower extremities (HP:0008968)2.72138622
35Cerebral hypomyelination (HP:0006808)2.68736707
36Generalized hypotonia (HP:0001290)2.65335939
37Pancreatic cysts (HP:0001737)2.63917206
38Bronchitis (HP:0012387)2.63769840
39Thickened helices (HP:0000391)2.61140112
40Clumsiness (HP:0002312)2.61023855
41Hyperthyroidism (HP:0000836)2.60284550
42Abnormality of cells of the erythroid lineage (HP:0012130)2.58988729
43Abnormal number of erythroid precursors (HP:0012131)2.56513122
44Decreased lacrimation (HP:0000633)2.56008390
45Cystic liver disease (HP:0006706)2.55576253
46Abnormality of the nasal mucosa (HP:0000433)2.55418913
47Broad distal phalanx of finger (HP:0009836)2.53745926
48Seborrheic dermatitis (HP:0001051)2.52061756
49Large eyes (HP:0001090)2.50055171
50Abnormal hemoglobin (HP:0011902)2.46891445
51Exercise-induced myalgia (HP:0003738)2.46885059
52Hepatocellular necrosis (HP:0001404)2.46693073
53Supranuclear gaze palsy (HP:0000605)2.45433572
54Abnormal rod and cone electroretinograms (HP:0008323)2.45107307
55Coronal craniosynostosis (HP:0004440)2.42816190
56Peripheral hypomyelination (HP:0007182)2.42741378
57Neuronal loss in central nervous system (HP:0002529)2.41100111
58Scanning speech (HP:0002168)2.40144924
59Molar tooth sign on MRI (HP:0002419)2.40058995
60Abnormality of midbrain morphology (HP:0002418)2.40058995
61Stridor (HP:0010307)2.37777848
62Anteriorly placed anus (HP:0001545)2.36690577
63Poor suck (HP:0002033)2.34602542
64Bell-shaped thorax (HP:0001591)2.32635974
65Chronic hepatic failure (HP:0100626)2.32215762
66Postaxial foot polydactyly (HP:0001830)2.28548327
67Asplenia (HP:0001746)2.28017996
68Increased circulating renin level (HP:0000848)2.27534683
69Partial agenesis of the corpus callosum (HP:0001338)2.26424277
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.26347741
71Progressive muscle weakness (HP:0003323)2.21251928
72Sensory axonal neuropathy (HP:0003390)2.17678163
73Colitis (HP:0002583)2.16936990
74Large for gestational age (HP:0001520)2.15304973
75Progressive neurologic deterioration (HP:0002344)2.12338977
76Loss of speech (HP:0002371)2.11792874
77Short femoral neck (HP:0100864)2.11719106
78Down-sloping shoulders (HP:0200021)2.11582198
79Panhypogammaglobulinemia (HP:0003139)2.10670804
80Sclerocornea (HP:0000647)2.10237530
81Choreoathetosis (HP:0001266)2.10009233
82Turricephaly (HP:0000262)2.09885101
83Abnormality of the renal medulla (HP:0100957)2.09737157
84Premature skin wrinkling (HP:0100678)2.07894983
85Partial duplication of thumb phalanx (HP:0009944)2.06965761
86Renal Fanconi syndrome (HP:0001994)2.06213986
87Truncus arteriosus (HP:0001660)2.05959563
88Deep palmar crease (HP:0006191)2.04405682
89Psychosis (HP:0000709)2.03954887
90Emotional lability (HP:0000712)2.03700302
91Ketoacidosis (HP:0001993)2.03500084
92Partial duplication of the phalanx of hand (HP:0009999)2.03061839
93Obstructive sleep apnea (HP:0002870)2.02076348
94Macrocytic anemia (HP:0001972)2.00257191
95Slow saccadic eye movements (HP:0000514)2.00131260
96Dysostosis multiplex (HP:0000943)1.99546438
97Poikiloderma (HP:0001029)1.97986734
98Hyperparathyroidism (HP:0000843)1.97739044
99Dysmetria (HP:0001310)1.97212834
100Pallor (HP:0000980)1.95982936
101Large earlobe (HP:0009748)1.94939336
102Gastrointestinal inflammation (HP:0004386)1.93276116
103Congenital hepatic fibrosis (HP:0002612)1.92790439
104Abnormality of the heme biosynthetic pathway (HP:0010472)1.92080079
105Cerebellar dysplasia (HP:0007033)1.90226495
106Inflammation of the large intestine (HP:0002037)1.89895078
107Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.89384638
108Reticulocytopenia (HP:0001896)1.88887064
109Aplasia/hypoplasia of the uterus (HP:0008684)1.88199274
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88072711
111Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87420188
112Degeneration of the lateral corticospinal tracts (HP:0002314)1.87420188
113* Anencephaly (HP:0002323)1.87128016
114Hypoplastic pelvis (HP:0008839)1.86573882
115Limb dystonia (HP:0002451)1.86117842
116Mitochondrial inheritance (HP:0001427)1.84903286
117Abnormality of the aortic arch (HP:0012303)1.83757106
118Severe visual impairment (HP:0001141)1.81746568
119Renal dysplasia (HP:0000110)1.81492612
120Synostosis involving the elbow (HP:0003938)1.79330084
121Humeroradial synostosis (HP:0003041)1.79330084
122Bowing of the arm (HP:0006488)1.79191053
123Bowed forearm bones (HP:0003956)1.79191053
124Retinitis pigmentosa (HP:0000510)1.78719755
125Abnormality of magnesium homeostasis (HP:0004921)1.77980990
126Increased intramyocellular lipid droplets (HP:0012240)1.76746265
127Abnormality of dental color (HP:0011073)1.76035725
128Optic nerve coloboma (HP:0000588)1.75736171
129Achilles tendon contracture (HP:0001771)1.75694862
130Exertional dyspnea (HP:0002875)1.75403553
131Hypomagnesemia (HP:0002917)1.73722469
132Agammaglobulinemia (HP:0004432)1.73469653
133Round ear (HP:0100830)1.73404775
134Congenital glaucoma (HP:0001087)1.72287449
135Esotropia (HP:0000565)1.69750973
136Hyperactive renin-angiotensin system (HP:0000841)1.69482032
137Rigidity (HP:0002063)1.68872641
138Plagiocephaly (HP:0001357)1.67402362
139Abnormality of calcium-phosphate metabolism (HP:0100530)1.67043628
140Neoplasm of the heart (HP:0100544)1.66924534
141Male pseudohermaphroditism (HP:0000037)1.66412831
142Leukodystrophy (HP:0002415)1.64854342
143Narrow nasal bridge (HP:0000446)1.64810926
144Myokymia (HP:0002411)1.61447791
145Hepatic necrosis (HP:0002605)1.60630631
146Fetal akinesia sequence (HP:0001989)1.56379139
147Myopathic facies (HP:0002058)1.56051049
148Gait imbalance (HP:0002141)1.56012816
149Nonprogressive disorder (HP:0003680)1.54801322
150Rectal prolapse (HP:0002035)1.53097993
151Abnormality of the intervertebral disk (HP:0005108)1.52571632
152Medial flaring of the eyebrow (HP:0010747)1.50069327
153Sleep apnea (HP:0010535)1.48158038
154Nephropathy (HP:0000112)1.47888398
155Bony spicule pigmentary retinopathy (HP:0007737)1.47827098
156Renal salt wasting (HP:0000127)1.47624552
157Increased muscle lipid content (HP:0009058)1.47540023
158Hyperkalemia (HP:0002153)1.46998920
159Decreased central vision (HP:0007663)1.42131623
160Annular pancreas (HP:0001734)1.41720238
161Visual hallucinations (HP:0002367)1.39501027
162Congenital primary aphakia (HP:0007707)1.37611579
163Hypercortisolism (HP:0001578)1.34919779
164Agitation (HP:0000713)1.34419749
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.33391403
166Absent epiphyses (HP:0010577)1.33391403
167Tubulointerstitial nephritis (HP:0001970)1.32807761
168Preaxial hand polydactyly (HP:0001177)1.32545290
169Aplasia/Hypoplasia of the tongue (HP:0010295)1.31739296
170Abnormality of the 4th metacarpal (HP:0010012)1.31631679
171Progressive cerebellar ataxia (HP:0002073)1.29000225
172Muscle fiber splitting (HP:0003555)1.27800498
173Tubular atrophy (HP:0000092)1.27555915
174Anomalous pulmonary venous return (HP:0010772)1.27348419
175Nephrogenic diabetes insipidus (HP:0009806)1.26114305
176Elevated erythrocyte sedimentation rate (HP:0003565)1.25845158
177Polycystic kidney dysplasia (HP:0000113)1.25216303
178Aplasia/hypoplasia of the femur (HP:0005613)1.24505334
179Depressed nasal ridge (HP:0000457)1.24145860
180Postaxial hand polydactyly (HP:0001162)1.23645692
181Abnormal ventriculo-arterial connection (HP:0011563)1.22759986
182Transposition of the great arteries (HP:0001669)1.22759986
183Abnormal connection of the cardiac segments (HP:0011545)1.22759986
184Decreased circulating renin level (HP:0003351)1.22422772
185Hyponatremia (HP:0002902)1.20867271
186Adrenal overactivity (HP:0002717)1.19199404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.41638110
2MAPK152.98145739
3TNIK2.83820681
4MAP3K102.66600739
5UHMK12.56014418
6ICK2.35029188
7PHKG12.29781775
8PHKG22.29781775
9CDK192.13976161
10STK392.09606953
11SMG12.08346951
12WNK42.07818848
13TNK22.07532627
14TESK12.04357216
15FES1.96249317
16MAPKAPK51.81447894
17NTRK11.79797383
18PRKD31.74476800
19MAP4K11.73756160
20MAP3K111.72651253
21DYRK21.64223720
22PRKD21.60773928
23BCKDK1.60000600
24PKN11.59042621
25CASK1.56795594
26TESK21.49285588
27IRAK21.48173480
28DYRK1B1.46899231
29ARAF1.42665155
30PRKCH1.39126604
31FGR1.34535616
32STK161.33806721
33CAMKK11.33609308
34HIPK21.30634688
35RPS6KA21.26919492
36KIT1.22984803
37NTRK31.21303313
38SIK11.20042805
39DAPK31.19581297
40FLT31.18852551
41MARK21.17428160
42OXSR11.14142711
43RPS6KA61.11424136
44RPS6KL11.11266432
45RPS6KC11.11266432
46EPHB11.09152363
47STK381.07801580
48IRAK11.05822964
49PINK11.03593262
50RIPK41.03545926
51AURKA1.01270573
52PBK0.98756065
53PLK40.96457051
54CSK0.96159522
55KSR20.93704728
56SGK2230.90460229
57SGK4940.90460229
58NTRK20.90360041
59CSF1R0.90296481
60BRAF0.89185457
61NME20.85343345
62MAP3K70.82646641
63PDPK10.81213029
64MAP2K40.80790181
65SIK20.80625223
66PIM20.77946107
67EPHA20.76205064
68ROCK20.76092021
69NME10.75232041
70MAP2K30.74597958
71BLK0.74158021
72TYRO30.73486492
73TAOK10.73317582
74ABL20.73057214
75MAP3K40.72515887
76GRK60.71396512
77BRD40.70827936
78CAMK2B0.69372882
79MATK0.69154755
80CAMK2D0.69038392
81BTK0.66176853
82OBSCN0.65653850
83MAPK110.65508564
84MARK10.65353121
85DYRK30.64211480
86TRIB30.63424936
87RPS6KA50.63212572
88MAP3K60.62134734
89CAMK2G0.61841495
90LCK0.61689995
91DYRK1A0.60140217
92MAP3K10.60132329
93WNK10.59846127
94VRK20.58989243
95CDK50.57874559
96PRKD10.57393992
97MAP2K20.57188100
98EEF2K0.56952305
99ILK0.56473123
100ERN10.55926677
101PRKCZ0.55851586
102MAP3K20.55571401
103PAK60.55157508
104MAPK120.54523153
105LIMK10.54206734
106MAPK40.54147564
107DDR20.53540155
108PRKCI0.51929178
109PDK10.51491565
110MAP2K70.51317491
111MAPK130.50786118
112CDK140.50650238
113CLK10.50271498
114MKNK20.49486924
115EPHA40.49017335
116RIPK10.48893282
117MUSK0.48833750
118RPS6KA10.48745007
119DMPK0.48643097
120STK110.45973185
121CDK11A0.45795900
122CAMK10.45605726
123EPHB20.44992044
124CSNK1G30.44840975
125MAP2K10.42562075
126MAP3K30.42412598
127YES10.42083967
128ZAK0.41218669
129SGK10.40470768
130INSRR0.40301944
131MTOR0.39888979
132DAPK10.39359006
133CDK150.39322910
134CHEK20.39016388
135CDC70.38695489
136TTN0.37255057
137MAP3K80.36992694
138CAMK40.36922486
139PRPF4B0.36604275
140PRKACA0.35818129
141CDK180.35506239
142LMTK20.35139777
143LYN0.34888975
144MAP3K90.34343930
145PAK20.33282470
146FYN0.33149331
147TAOK30.31602007
148PRKAA20.31484125
149IKBKE0.31029040
150PRKCQ0.30902985
151ADRBK10.30606057
152PNCK0.30191129
153LRRK20.29359911
154IRAK30.29330332

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.15664107
2Sulfur relay system_Homo sapiens_hsa041223.30867423
3Phenylalanine metabolism_Homo sapiens_hsa003602.71731139
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.38161041
5Oxidative phosphorylation_Homo sapiens_hsa001902.37316058
6Protein export_Homo sapiens_hsa030602.36838824
7Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.36156698
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31375725
9Parkinsons disease_Homo sapiens_hsa050122.28457461
10Fatty acid elongation_Homo sapiens_hsa000621.96172623
11Alzheimers disease_Homo sapiens_hsa050101.93076921
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89772767
13Fatty acid biosynthesis_Homo sapiens_hsa000611.88423490
14Tyrosine metabolism_Homo sapiens_hsa003501.76192905
15RNA polymerase_Homo sapiens_hsa030201.69050604
16Cardiac muscle contraction_Homo sapiens_hsa042601.67737480
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62009936
18Morphine addiction_Homo sapiens_hsa050321.58093827
19GABAergic synapse_Homo sapiens_hsa047271.55508379
20Primary immunodeficiency_Homo sapiens_hsa053401.50999115
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45484327
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43808815
23Insulin secretion_Homo sapiens_hsa049111.42251116
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38752727
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35515342
26beta-Alanine metabolism_Homo sapiens_hsa004101.32910878
27Hedgehog signaling pathway_Homo sapiens_hsa043401.31050232
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.29716116
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29079652
30Alcoholism_Homo sapiens_hsa050341.28881044
31Glutamatergic synapse_Homo sapiens_hsa047241.28829565
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26396037
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22643612
34B cell receptor signaling pathway_Homo sapiens_hsa046621.22423067
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.20876836
36Cocaine addiction_Homo sapiens_hsa050301.19905952
37Salivary secretion_Homo sapiens_hsa049701.18130063
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17383235
39Other glycan degradation_Homo sapiens_hsa005111.14651178
40Renal cell carcinoma_Homo sapiens_hsa052111.14494620
41Collecting duct acid secretion_Homo sapiens_hsa049661.14470514
42Notch signaling pathway_Homo sapiens_hsa043301.12650503
43Steroid biosynthesis_Homo sapiens_hsa001001.12529711
44Bladder cancer_Homo sapiens_hsa052191.10980823
45Gastric acid secretion_Homo sapiens_hsa049711.10218914
46Long-term depression_Homo sapiens_hsa047301.09442638
47Huntingtons disease_Homo sapiens_hsa050161.05535639
48Circadian entrainment_Homo sapiens_hsa047131.05219855
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04740679
50Olfactory transduction_Homo sapiens_hsa047401.03267722
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03026265
52Gap junction_Homo sapiens_hsa045401.02796269
53Sphingolipid signaling pathway_Homo sapiens_hsa040711.01917169
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01636322
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99730569
56Basal cell carcinoma_Homo sapiens_hsa052170.95721343
57Pancreatic secretion_Homo sapiens_hsa049720.95164293
58Melanogenesis_Homo sapiens_hsa049160.93478674
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93014692
60Arginine and proline metabolism_Homo sapiens_hsa003300.92611090
61Serotonergic synapse_Homo sapiens_hsa047260.92200631
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91701449
63Histidine metabolism_Homo sapiens_hsa003400.91636196
64ErbB signaling pathway_Homo sapiens_hsa040120.91388543
65ABC transporters_Homo sapiens_hsa020100.91097570
66Pyrimidine metabolism_Homo sapiens_hsa002400.89650815
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.89398171
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88082327
69Acute myeloid leukemia_Homo sapiens_hsa052210.87804080
70Phototransduction_Homo sapiens_hsa047440.87310599
71Sphingolipid metabolism_Homo sapiens_hsa006000.86366274
72Renin secretion_Homo sapiens_hsa049240.82607175
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82475808
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81869256
75GnRH signaling pathway_Homo sapiens_hsa049120.79797328
76Type II diabetes mellitus_Homo sapiens_hsa049300.79717610
77Dopaminergic synapse_Homo sapiens_hsa047280.78992989
78Nitrogen metabolism_Homo sapiens_hsa009100.78219312
79VEGF signaling pathway_Homo sapiens_hsa043700.76221080
80Long-term potentiation_Homo sapiens_hsa047200.75932200
81Cholinergic synapse_Homo sapiens_hsa047250.75888573
82Viral myocarditis_Homo sapiens_hsa054160.75732095
83Endometrial cancer_Homo sapiens_hsa052130.73805175
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73545384
85Chemical carcinogenesis_Homo sapiens_hsa052040.73396912
86Colorectal cancer_Homo sapiens_hsa052100.69837476
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67484297
88Wnt signaling pathway_Homo sapiens_hsa043100.67121161
89Fatty acid metabolism_Homo sapiens_hsa012120.66119885
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.65876189
91Dorso-ventral axis formation_Homo sapiens_hsa043200.65336102
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.65220887
93Dilated cardiomyopathy_Homo sapiens_hsa054140.64092451
94MAPK signaling pathway_Homo sapiens_hsa040100.63273709
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60586213
96Purine metabolism_Homo sapiens_hsa002300.59991502
97Autoimmune thyroid disease_Homo sapiens_hsa053200.58897116
98Axon guidance_Homo sapiens_hsa043600.58420549
99Glutathione metabolism_Homo sapiens_hsa004800.57638164
100Systemic lupus erythematosus_Homo sapiens_hsa053220.57252774
101Spliceosome_Homo sapiens_hsa030400.56743185
102Non-small cell lung cancer_Homo sapiens_hsa052230.55856556
103Nucleotide excision repair_Homo sapiens_hsa034200.54169222
104Ether lipid metabolism_Homo sapiens_hsa005650.53822175
105Choline metabolism in cancer_Homo sapiens_hsa052310.53697883
106Synaptic vesicle cycle_Homo sapiens_hsa047210.52662324
107Lysine degradation_Homo sapiens_hsa003100.52120842
108Calcium signaling pathway_Homo sapiens_hsa040200.50554775
109Graft-versus-host disease_Homo sapiens_hsa053320.50259442
110Allograft rejection_Homo sapiens_hsa053300.50213058
111Folate biosynthesis_Homo sapiens_hsa007900.49715661
112Linoleic acid metabolism_Homo sapiens_hsa005910.49702378
113DNA replication_Homo sapiens_hsa030300.49551272
114Taste transduction_Homo sapiens_hsa047420.49389131
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.48940616
116Insulin signaling pathway_Homo sapiens_hsa049100.48767021
117cAMP signaling pathway_Homo sapiens_hsa040240.47148333
118Pancreatic cancer_Homo sapiens_hsa052120.46992281
119Endocytosis_Homo sapiens_hsa041440.46331306
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45136950
121Amphetamine addiction_Homo sapiens_hsa050310.43916490
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42780655
123Base excision repair_Homo sapiens_hsa034100.42773079
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42559592
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41865724
126Nicotine addiction_Homo sapiens_hsa050330.41364823
127Regulation of autophagy_Homo sapiens_hsa041400.41109811
128Type I diabetes mellitus_Homo sapiens_hsa049400.41074649
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40976745
130Melanoma_Homo sapiens_hsa052180.40915240
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40747322
132Oxytocin signaling pathway_Homo sapiens_hsa049210.39237397
133mTOR signaling pathway_Homo sapiens_hsa041500.38992858
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.38718902
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37729514
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36943312

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