FXN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.13996384
2ribosomal small subunit assembly (GO:0000028)5.71949409
3telomere maintenance via semi-conservative replication (GO:0032201)5.24360413
4DNA strand elongation involved in DNA replication (GO:0006271)5.02352065
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.94257841
6DNA strand elongation (GO:0022616)4.87494614
7DNA replication initiation (GO:0006270)4.61786331
8telomere maintenance via recombination (GO:0000722)4.56548080
9protein complex biogenesis (GO:0070271)4.46091740
10mitochondrial respiratory chain complex assembly (GO:0033108)4.36656844
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.25901518
12NADH dehydrogenase complex assembly (GO:0010257)4.25901518
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.25901518
14mitotic recombination (GO:0006312)4.20039879
15DNA replication checkpoint (GO:0000076)4.17205071
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.13147797
17viral transcription (GO:0019083)4.11559504
18maturation of SSU-rRNA (GO:0030490)4.07503076
19CENP-A containing nucleosome assembly (GO:0034080)4.03705337
20proteasome assembly (GO:0043248)4.02589902
21translational termination (GO:0006415)3.98457773
22establishment of protein localization to mitochondrial membrane (GO:0090151)3.98129083
23telomere maintenance via telomere lengthening (GO:0010833)3.97483887
24kinetochore organization (GO:0051383)3.93047524
25chromatin remodeling at centromere (GO:0031055)3.92913528
26regulation of mitochondrial translation (GO:0070129)3.92306660
27kinetochore assembly (GO:0051382)3.91359379
28ribosomal large subunit biogenesis (GO:0042273)3.89818172
29cytochrome complex assembly (GO:0017004)3.85238316
30nucleotide-excision repair, DNA gap filling (GO:0006297)3.78732438
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.75919207
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.75919207
33ATP synthesis coupled proton transport (GO:0015986)3.74719994
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.74719994
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.72232067
36ribosomal small subunit biogenesis (GO:0042274)3.70475268
37translational elongation (GO:0006414)3.66667319
38pseudouridine synthesis (GO:0001522)3.65857007
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.62150827
40chaperone-mediated protein transport (GO:0072321)3.59971871
41cotranslational protein targeting to membrane (GO:0006613)3.59594285
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.59005320
43protein targeting to ER (GO:0045047)3.57731229
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53655864
45peptidyl-histidine modification (GO:0018202)3.49951858
46DNA unwinding involved in DNA replication (GO:0006268)3.49918740
47deoxyribonucleotide biosynthetic process (GO:0009263)3.47771296
48* oxidative phosphorylation (GO:0006119)3.46523316
49protein neddylation (GO:0045116)3.43906595
50nucleobase biosynthetic process (GO:0046112)3.43678625
51ribonucleoprotein complex biogenesis (GO:0022613)3.42211620
52IMP biosynthetic process (GO:0006188)3.40395475
53protein localization to endoplasmic reticulum (GO:0070972)3.38561606
54deoxyribose phosphate biosynthetic process (GO:0046385)3.37945622
552-deoxyribonucleotide biosynthetic process (GO:0009265)3.37945622
56ubiquinone biosynthetic process (GO:0006744)3.37701348
57DNA replication-independent nucleosome assembly (GO:0006336)3.37597879
58DNA replication-independent nucleosome organization (GO:0034724)3.37597879
59spliceosomal snRNP assembly (GO:0000387)3.36312963
60establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36100214
61termination of RNA polymerase III transcription (GO:0006386)3.34008246
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.34008246
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32316592
64respiratory electron transport chain (GO:0022904)3.29938660
65electron transport chain (GO:0022900)3.28161659
66transcription-coupled nucleotide-excision repair (GO:0006283)3.27930467
67regulation of nuclear cell cycle DNA replication (GO:0033262)3.27387948
68translational initiation (GO:0006413)3.26772444
69purine nucleobase biosynthetic process (GO:0009113)3.26390486
70maturation of 5.8S rRNA (GO:0000460)3.25957317
71translation (GO:0006412)3.22595803
72mitotic metaphase plate congression (GO:0007080)3.22498228
73mitochondrial RNA metabolic process (GO:0000959)3.21990455
74rRNA modification (GO:0000154)3.19507998
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18907815
76ribosome biogenesis (GO:0042254)3.18723750
77protein targeting to mitochondrion (GO:0006626)3.17494754
78pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.16451422
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16295816
80ubiquinone metabolic process (GO:0006743)3.14348836
81viral life cycle (GO:0019058)3.14016169
82RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11484597
83water-soluble vitamin biosynthetic process (GO:0042364)3.11280778
84L-methionine salvage (GO:0071267)3.11178066
85L-methionine biosynthetic process (GO:0071265)3.11178066
86amino acid salvage (GO:0043102)3.11178066
87telomere maintenance (GO:0000723)3.11017112
88DNA double-strand break processing (GO:0000729)3.10468832
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09858328
90telomere organization (GO:0032200)3.09818521
91viral mRNA export from host cell nucleus (GO:0046784)3.08964908
92deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.08418364
93mannosylation (GO:0097502)3.08154344
94branched-chain amino acid catabolic process (GO:0009083)3.07398022
95cellular protein complex disassembly (GO:0043624)3.06296890
96formation of translation preinitiation complex (GO:0001731)3.05358548
97rRNA processing (GO:0006364)3.04687257
98tRNA methylation (GO:0030488)3.04148155
99somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03959152
100somatic hypermutation of immunoglobulin genes (GO:0016446)3.03959152
101maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.03957305
102tRNA processing (GO:0008033)3.03403151
103protein-cofactor linkage (GO:0018065)3.00596074
104cellular component biogenesis (GO:0044085)2.99749299
105folic acid-containing compound biosynthetic process (GO:0009396)2.99546286
106negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98900580
107spliceosomal complex assembly (GO:0000245)2.97477604
108deoxyribonucleotide catabolic process (GO:0009264)2.97017908
109rRNA metabolic process (GO:0016072)2.96923236
110establishment of protein localization to mitochondrion (GO:0072655)2.96218095
111histone exchange (GO:0043486)2.96150714
112rRNA methylation (GO:0031167)2.95733715
113negative regulation of ligase activity (GO:0051352)2.95604928
114negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95604928
115protein localization to chromosome, centromeric region (GO:0071459)2.95556478
116regulation of double-strand break repair via homologous recombination (GO:0010569)2.94589591
117replication fork processing (GO:0031297)2.93084493
118meiotic chromosome segregation (GO:0045132)2.92751369
119cullin deneddylation (GO:0010388)2.92405817
120metaphase plate congression (GO:0051310)2.91032274
121protein localization to kinetochore (GO:0034501)2.90332530
122base-excision repair, AP site formation (GO:0006285)2.89548699
123kynurenine metabolic process (GO:0070189)2.88725801
124regulation of cellular amino acid metabolic process (GO:0006521)2.88213428
125protein deneddylation (GO:0000338)2.87806470
126IMP metabolic process (GO:0046040)2.87547372
127pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.87515900
128RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.86909728
129mismatch repair (GO:0006298)2.86273725
130deoxyribose phosphate catabolic process (GO:0046386)2.86122521
131protein localization to mitochondrion (GO:0070585)2.84937879
132regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82391925
133anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82140467
134G1/S transition of mitotic cell cycle (GO:0000082)2.81373237
135cell cycle G1/S phase transition (GO:0044843)2.81373237
136DNA synthesis involved in DNA repair (GO:0000731)2.81096427
137DNA-dependent DNA replication (GO:0006261)2.80497909
138DNA replication (GO:0006260)2.78933447
139intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78338029
140signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78338029
141nucleobase-containing small molecule interconversion (GO:0015949)2.77362445
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77238228
143transcription from mitochondrial promoter (GO:0006390)2.76820944
144tRNA metabolic process (GO:0006399)2.76414755
145protein complex disassembly (GO:0043241)2.75213351
146establishment of chromosome localization (GO:0051303)2.74721782
147signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74055830
148signal transduction involved in DNA damage checkpoint (GO:0072422)2.74055830
149DNA catabolic process, exonucleolytic (GO:0000738)2.73563333
150ATP biosynthetic process (GO:0006754)2.73109664
151nuclear-transcribed mRNA catabolic process (GO:0000956)2.72817345
152signal transduction involved in cell cycle checkpoint (GO:0072395)2.72582834
153pyrimidine nucleotide catabolic process (GO:0006244)2.72541976
154DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72532072
155positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72108715
156signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71665598
157signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71665598
158signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71665598
159respiratory chain complex IV assembly (GO:0008535)2.71548211
160pteridine-containing compound biosynthetic process (GO:0042559)2.70713305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.71298426
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.10383973
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88802798
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86267793
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44850494
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.26788419
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.16715416
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.05724067
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04256290
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97111913
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.89890013
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.88003050
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.73366269
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72711968
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72285711
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68541282
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66511563
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52275277
19VDR_23849224_ChIP-Seq_CD4+_Human2.38959510
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29365632
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27121720
22XRN2_22483619_ChIP-Seq_HELA_Human2.22470240
23FOXP3_21729870_ChIP-Seq_TREG_Human2.20887372
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15012341
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13686738
26* SRF_21415370_ChIP-Seq_HL-1_Mouse2.12130553
27VDR_22108803_ChIP-Seq_LS180_Human2.09228709
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08468115
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07763907
30DCP1A_22483619_ChIP-Seq_HELA_Human2.07272041
31ZNF274_21170338_ChIP-Seq_K562_Hela2.02005547
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97267941
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.96726318
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94825770
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94417344
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92123652
37GABP_19822575_ChIP-Seq_HepG2_Human1.91683998
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89726620
39* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82749389
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82716134
41TTF2_22483619_ChIP-Seq_HELA_Human1.78895463
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.78057540
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74056153
44ELK1_19687146_ChIP-ChIP_HELA_Human1.73940321
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70874142
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.69736802
47IGF1R_20145208_ChIP-Seq_DFB_Human1.68818240
48CIITA_25753668_ChIP-Seq_RAJI_Human1.67101030
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66898428
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63845324
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60542872
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.59233781
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57693035
54AR_21909140_ChIP-Seq_LNCAP_Human1.53778562
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52801041
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50975071
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48285945
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47599843
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43809731
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42894276
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38535129
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38371073
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34719531
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32586056
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30656441
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29812950
67EWS_26573619_Chip-Seq_HEK293_Human1.28559257
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.27702441
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22555800
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21895589
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.20440961
72KDM5A_27292631_Chip-Seq_BREAST_Human1.18985287
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15871368
74* MYC_18940864_ChIP-ChIP_HL60_Human1.15441160
75SPI1_23547873_ChIP-Seq_NB4_Human1.12960686
76SCL_19346495_ChIP-Seq_HPC-7_Human1.12146912
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11936625
78TP53_22573176_ChIP-Seq_HFKS_Human1.10369261
79MYC_22102868_ChIP-Seq_BL_Human1.09498503
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09134460
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08764142
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07358624
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02005326
84FUS_26573619_Chip-Seq_HEK293_Human1.01262161
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00301850
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98658415
87* IRF1_19129219_ChIP-ChIP_H3396_Human0.98373371
88TAF15_26573619_Chip-Seq_HEK293_Human0.96546177
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96348150
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96196124
91IRF8_22096565_ChIP-ChIP_GC-B_Human0.95963456
92VDR_21846776_ChIP-Seq_THP-1_Human0.94630832
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.93591220
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93591220
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93049164
96AR_20517297_ChIP-Seq_VCAP_Human0.92423723
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92056643
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90615985
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89306080
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89058291
101STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87876979
102EGR1_19374776_ChIP-ChIP_THP-1_Human0.87729269
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86915379
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84624675
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84349696
106FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84343881
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82851748
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82296299
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82175937
110ELK1_22589737_ChIP-Seq_MCF10A_Human0.82162057
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82002727
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81961728
113TFEB_21752829_ChIP-Seq_HELA_Human0.81243226
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78827084
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78815203
116KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.78789276
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.78193219
118GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77607589
119CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76149887
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75865798
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75659460
122NCOR_22424771_ChIP-Seq_293T_Human0.72164751
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.71037802
124ERA_21632823_ChIP-Seq_H3396_Human0.70603060
125NANOG_20526341_ChIP-Seq_ESCs_Human0.70505030
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.69434712
127ER_23166858_ChIP-Seq_MCF-7_Human0.67293260
128FOXP1_21924763_ChIP-Seq_HESCs_Human0.66638920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.89082999
2MP0010094_abnormal_chromosome_stability4.11111838
3MP0003111_abnormal_nucleus_morphology3.75156279
4MP0008058_abnormal_DNA_repair3.52876316
5MP0003077_abnormal_cell_cycle3.37820464
6MP0008057_abnormal_DNA_replication3.31829718
7MP0004957_abnormal_blastocyst_morpholog3.30415065
8MP0008007_abnormal_cellular_replicative2.93573257
9MP0002396_abnormal_hematopoietic_system2.84540186
10MP0004147_increased_porphyrin_level2.58370458
11MP0006292_abnormal_olfactory_placode2.46609893
12MP0002132_abnormal_respiratory_system2.19272155
13* MP0006035_abnormal_mitochondrial_morpho2.13478069
14MP0009379_abnormal_foot_pigmentation2.13388615
15MP0008932_abnormal_embryonic_tissue2.09927619
16MP0000490_abnormal_crypts_of2.08492100
17MP0003806_abnormal_nucleotide_metabolis2.04189276
18MP0002234_abnormal_pharynx_morphology2.02841297
19MP0003656_abnormal_erythrocyte_physiolo2.01810898
20MP0002736_abnormal_nociception_after2.00660535
21MP0002837_dystrophic_cardiac_calcinosis1.84728667
22MP0005397_hematopoietic_system_phenotyp1.82464742
23MP0001545_abnormal_hematopoietic_system1.82464742
24MP0003786_premature_aging1.82176628
25MP0001835_abnormal_antigen_presentation1.77672245
26MP0003763_abnormal_thymus_physiology1.76524078
27* MP0003186_abnormal_redox_activity1.73607582
28MP0006072_abnormal_retinal_apoptosis1.71880809
29MP0004808_abnormal_hematopoietic_stem1.65150354
30MP0005075_abnormal_melanosome_morpholog1.64493339
31* MP0006036_abnormal_mitochondrial_physio1.60353258
32MP0001853_heart_inflammation1.57032673
33MP0006054_spinal_hemorrhage1.56747446
34MP0009333_abnormal_splenocyte_physiolog1.54653133
35MP0003195_calcinosis1.54370488
36MP0005645_abnormal_hypothalamus_physiol1.54306539
37MP0003252_abnormal_bile_duct1.54262669
38MP0008872_abnormal_physiological_respon1.51916278
39MP0008875_abnormal_xenobiotic_pharmacok1.51825816
40MP0009697_abnormal_copulation1.51038953
41MP0005646_abnormal_pituitary_gland1.46663182
42MP0001968_abnormal_touch/_nociception1.44249956
43MP0002398_abnormal_bone_marrow1.39767008
44* MP0000313_abnormal_cell_death1.38561216
45MP0001764_abnormal_homeostasis1.32579044
46MP0002019_abnormal_tumor_incidence1.30538981
47MP0000350_abnormal_cell_proliferation1.30183242
48MP0009785_altered_susceptibility_to1.29905937
49MP0000689_abnormal_spleen_morphology1.27765023
50MP0004145_abnormal_muscle_electrophysio1.26221514
51MP0005174_abnormal_tail_pigmentation1.26168704
52MP0002722_abnormal_immune_system1.24485555
53* MP0005636_abnormal_mineral_homeostasis1.24072654
54MP0005671_abnormal_response_to1.23738946
55MP0005253_abnormal_eye_physiology1.22384439
56MP0001529_abnormal_vocalization1.22098484
57MP0002095_abnormal_skin_pigmentation1.21774051
58MP0005551_abnormal_eye_electrophysiolog1.20487924
59MP0003718_maternal_effect1.19808681
60MP0000703_abnormal_thymus_morphology1.18109164
61MP0002429_abnormal_blood_cell1.15439294
62MP0000566_synostosis1.15055724
63MP0000653_abnormal_sex_gland1.11623013
64MP0004215_abnormal_myocardial_fiber1.07677738
65MP0001929_abnormal_gametogenesis1.07108017
66MP0005410_abnormal_fertilization1.07051114
67MP0003123_paternal_imprinting1.05962199
68MP0003011_delayed_dark_adaptation1.05734021
69MP0002876_abnormal_thyroid_physiology1.05326781
70* MP0000358_abnormal_cell_content/1.05255014
71MP0008789_abnormal_olfactory_epithelium1.04554205
72MP0000015_abnormal_ear_pigmentation1.04150114
73MP0000685_abnormal_immune_system1.04024203
74MP0002638_abnormal_pupillary_reflex1.03740985
75MP0002148_abnormal_hypersensitivity_rea1.03409256
76MP0000716_abnormal_immune_system1.02439706
77MP0005332_abnormal_amino_acid1.00250377
78MP0008877_abnormal_DNA_methylation0.99681931
79MP0003567_abnormal_fetal_cardiomyocyte0.99064100
80MP0005025_abnormal_response_to0.98273313
81MP0001188_hyperpigmentation0.95927723
82MP0008995_early_reproductive_senescence0.95700528
83MP0002160_abnormal_reproductive_system0.95338973
84MP0001800_abnormal_humoral_immune0.93810459
85MP0002420_abnormal_adaptive_immunity0.92595408
86MP0001819_abnormal_immune_cell0.92251544
87MP0001661_extended_life_span0.91877669
88MP0001119_abnormal_female_reproductive0.91788605
89MP0002452_abnormal_antigen_presenting0.89133269
90MP0003646_muscle_fatigue0.88670074
91MP0001905_abnormal_dopamine_level0.88587807
92MP0003787_abnormal_imprinting0.88130398
93MP0000858_altered_metastatic_potential0.86706021
94MP0000631_abnormal_neuroendocrine_gland0.86602726
95MP0003724_increased_susceptibility_to0.86156192
96MP0004133_heterotaxia0.85796292
97MP0002938_white_spotting0.85630812
98* MP0001730_embryonic_growth_arrest0.85232571
99MP0003698_abnormal_male_reproductive0.84820348
100* MP0002080_prenatal_lethality0.83666668
101MP0002723_abnormal_immune_serum0.83212767
102MP0001672_abnormal_embryogenesis/_devel0.82887062
103MP0005380_embryogenesis_phenotype0.82887062
104MP0001986_abnormal_taste_sensitivity0.82869616
105MP0002210_abnormal_sex_determination0.82117654
106MP0010307_abnormal_tumor_latency0.82052276
107MP0000678_abnormal_parathyroid_gland0.81012511
108MP0000749_muscle_degeneration0.81002890
109* MP0001697_abnormal_embryo_size0.80473975
110MP0005389_reproductive_system_phenotype0.79389689
111MP0005084_abnormal_gallbladder_morpholo0.79280059
112MP0004043_abnormal_pH_regulation0.79036406
113MP0005266_abnormal_metabolism0.78937903
114MP0000049_abnormal_middle_ear0.77178529
115MP0009046_muscle_twitch0.76666244
116MP0004782_abnormal_surfactant_physiolog0.76533791
117MP0010155_abnormal_intestine_physiology0.76472021
118MP0005377_hearing/vestibular/ear_phenot0.76181994
119MP0003878_abnormal_ear_physiology0.76181994
120MP0003943_abnormal_hepatobiliary_system0.75260929
121MP0003984_embryonic_growth_retardation0.75177698
122MP0000372_irregular_coat_pigmentation0.73763622
123MP0002163_abnormal_gland_morphology0.73541409
124MP0003119_abnormal_digestive_system0.73486700
125MP0001293_anophthalmia0.73204050
126MP0001919_abnormal_reproductive_system0.72885781
127MP0005395_other_phenotype0.72519054
128MP0002088_abnormal_embryonic_growth/wei0.70758558
129MP0002102_abnormal_ear_morphology0.68705322
130MP0008873_increased_physiological_sensi0.68209867
131MP0004142_abnormal_muscle_tone0.67141863
132MP0002405_respiratory_system_inflammati0.66686484
133MP0002138_abnormal_hepatobiliary_system0.66449243
134MP0002277_abnormal_respiratory_mucosa0.64996406
135MP0001485_abnormal_pinna_reflex0.64480034
136MP0008469_abnormal_protein_level0.64423208
137MP0003890_abnormal_embryonic-extraembry0.64132783
138MP0005647_abnormal_sex_gland0.64084564
139MP0005464_abnormal_platelet_physiology0.64026105
140MP0005000_abnormal_immune_tolerance0.63331485
141MP0005083_abnormal_biliary_tract0.62934733
142MP0005220_abnormal_exocrine_pancreas0.62890269
143MP0005670_abnormal_white_adipose0.62006928
144MP0003315_abnormal_perineum_morphology0.61707496
145MP0001145_abnormal_male_reproductive0.61616989
146MP0009764_decreased_sensitivity_to0.61544292
147MP0005379_endocrine/exocrine_gland_phen0.61497879
148MP0001186_pigmentation_phenotype0.61012786

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.86764905
2Abnormality of cells of the erythroid lineage (HP:0012130)4.57209351
3Reticulocytopenia (HP:0001896)4.56631148
4Aplastic anemia (HP:0001915)4.28859379
5Birth length less than 3rd percentile (HP:0003561)4.25489994
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.21784066
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.11387503
8Chromsome breakage (HP:0040012)3.95864633
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.41454676
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.41454676
11Abnormality of the preputium (HP:0100587)3.37695955
12Type I transferrin isoform profile (HP:0003642)3.16284113
13Mitochondrial inheritance (HP:0001427)3.14700961
14Meckel diverticulum (HP:0002245)3.14335368
15Oral leukoplakia (HP:0002745)3.13226385
16Pallor (HP:0000980)3.08023249
17Acute necrotizing encephalopathy (HP:0006965)3.04990618
18Abnormality of the ileum (HP:0001549)3.01995978
19Hepatocellular necrosis (HP:0001404)3.01167597
20Increased serum lactate (HP:0002151)3.00386152
21Hepatic necrosis (HP:0002605)2.99433241
22Increased CSF lactate (HP:0002490)2.96288706
23Abnormality of chromosome stability (HP:0003220)2.95755136
24Aplasia/Hypoplasia of the sacrum (HP:0008517)2.94837127
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.94018825
26Microretrognathia (HP:0000308)2.91078966
27Prostate neoplasm (HP:0100787)2.90753514
28Abnormal mitochondria in muscle tissue (HP:0008316)2.89653548
29Reduced antithrombin III activity (HP:0001976)2.87464354
30Macrocytic anemia (HP:0001972)2.80586340
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75833008
32Hyperglycinemia (HP:0002154)2.74915619
33Pancreatic cysts (HP:0001737)2.71155958
34Increased hepatocellular lipid droplets (HP:0006565)2.68168786
353-Methylglutaconic aciduria (HP:0003535)2.68105650
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.65144276
37Pancytopenia (HP:0001876)2.64292491
38Breast hypoplasia (HP:0003187)2.63728528
39Pancreatic fibrosis (HP:0100732)2.57433440
40Myelodysplasia (HP:0002863)2.57427998
41Bone marrow hypocellularity (HP:0005528)2.57023665
42Microvesicular hepatic steatosis (HP:0001414)2.55214183
43Acute encephalopathy (HP:0006846)2.53652677
44Petechiae (HP:0000967)2.52455445
45Exertional dyspnea (HP:0002875)2.50696876
46Abnormality of the anterior horn cell (HP:0006802)2.48394618
47Degeneration of anterior horn cells (HP:0002398)2.48394618
48Lethargy (HP:0001254)2.48243606
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46433981
50Lipid accumulation in hepatocytes (HP:0006561)2.44954358
51Duodenal stenosis (HP:0100867)2.43730711
52Small intestinal stenosis (HP:0012848)2.43730711
53Clubbing of toes (HP:0100760)2.43167615
5411 pairs of ribs (HP:0000878)2.41235604
55Patellar aplasia (HP:0006443)2.36278533
56Abnormality of DNA repair (HP:0003254)2.36124668
57Optic disc pallor (HP:0000543)2.34549918
58Absent thumb (HP:0009777)2.34195238
59Thrombocytosis (HP:0001894)2.33566639
60Abnormality of the prostate (HP:0008775)2.33136341
61Colon cancer (HP:0003003)2.32684356
62Hyperglycinuria (HP:0003108)2.32605995
63Lactic acidosis (HP:0003128)2.32234928
64Exercise intolerance (HP:0003546)2.30338742
65Progressive macrocephaly (HP:0004481)2.30260777
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26449450
67Abnormal protein N-linked glycosylation (HP:0012347)2.26449450
68Abnormal protein glycosylation (HP:0012346)2.26449450
69Abnormal glycosylation (HP:0012345)2.26449450
70Aplasia/Hypoplasia of the patella (HP:0006498)2.23518987
71Type 2 muscle fiber atrophy (HP:0003554)2.23208775
72Muscle fiber atrophy (HP:0100295)2.22963369
73Abnormality of serum amino acid levels (HP:0003112)2.22840248
74Renal cortical cysts (HP:0000803)2.22204590
75Rough bone trabeculation (HP:0100670)2.22179344
76Methylmalonic acidemia (HP:0002912)2.22134246
77Molar tooth sign on MRI (HP:0002419)2.21207037
78Abnormality of midbrain morphology (HP:0002418)2.21207037
79Premature graying of hair (HP:0002216)2.18803386
80Triphalangeal thumb (HP:0001199)2.16655600
81Abnormality of pyrimidine metabolism (HP:0004353)2.16433475
82True hermaphroditism (HP:0010459)2.14679721
83Abnormality of reticulocytes (HP:0004312)2.14172506
84Duplicated collecting system (HP:0000081)2.13746253
85Increased intramyocellular lipid droplets (HP:0012240)2.12997563
86Abnormality of alanine metabolism (HP:0010916)2.10567318
87Hyperalaninemia (HP:0003348)2.10567318
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10567318
89Neoplasm of the adrenal gland (HP:0100631)2.08474795
90Abnormality of serine family amino acid metabolism (HP:0010894)2.08432112
91Abnormality of glycine metabolism (HP:0010895)2.08432112
92Renal Fanconi syndrome (HP:0001994)2.08120469
93Abolished electroretinogram (ERG) (HP:0000550)2.05463320
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05222819
95Abnormal biliary tract physiology (HP:0012439)2.05110042
96Bile duct proliferation (HP:0001408)2.05110042
97Leukodystrophy (HP:0002415)2.04517494
98CNS demyelination (HP:0007305)2.03968895
99Abnormality of the renal collecting system (HP:0004742)1.98239642
100Methylmalonic aciduria (HP:0012120)1.96573031
101Cerebral hypomyelination (HP:0006808)1.95382778
102Neoplasm of the adrenal cortex (HP:0100641)1.94387125
103Respiratory difficulties (HP:0002880)1.94321422
104Abnormality of the duodenum (HP:0002246)1.93413000
105IgM deficiency (HP:0002850)1.92890446
106Abnormality of the renal cortex (HP:0011035)1.92233477
107Nausea (HP:0002018)1.91547837
108Progressive inability to walk (HP:0002505)1.91231981
109Sloping forehead (HP:0000340)1.90924563
110Nephronophthisis (HP:0000090)1.90599210
111Attenuation of retinal blood vessels (HP:0007843)1.90447339
112Selective tooth agenesis (HP:0001592)1.90006204
113Lymphoma (HP:0002665)1.88664770
114Generalized aminoaciduria (HP:0002909)1.87694788
115Sclerocornea (HP:0000647)1.87656894
116Respiratory failure (HP:0002878)1.87273958
117Optic nerve coloboma (HP:0000588)1.86923617
118Increased muscle lipid content (HP:0009058)1.86458061
119Medulloblastoma (HP:0002885)1.85790454
120Dicarboxylic aciduria (HP:0003215)1.85689172
121Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85689172
122Progressive microcephaly (HP:0000253)1.84776744
123Cerebral palsy (HP:0100021)1.84496229
124Abnormality of the carotid arteries (HP:0005344)1.83884454
125Gaze-evoked nystagmus (HP:0000640)1.82986085
126Severe visual impairment (HP:0001141)1.81301911
127Prolonged bleeding time (HP:0003010)1.80505672
128Type II lissencephaly (HP:0007260)1.76636162
129Cleft eyelid (HP:0000625)1.76620869
130Ectopic kidney (HP:0000086)1.76201539
131Medial flaring of the eyebrow (HP:0010747)1.75815004
132Cerebral edema (HP:0002181)1.75334160
133Cellular immunodeficiency (HP:0005374)1.75150938
134Aplasia/hypoplasia of the uterus (HP:0008684)1.74406492
135Hypoplasia of the pons (HP:0012110)1.73716184
136Bilateral microphthalmos (HP:0007633)1.72630505
137Glycosuria (HP:0003076)1.72441713
138Abnormality of urine glucose concentration (HP:0011016)1.72441713
139Hypochromic anemia (HP:0001931)1.72140893
140Poor head control (HP:0002421)1.71237760
141Sparse eyelashes (HP:0000653)1.70769976
142Pendular nystagmus (HP:0012043)1.70685748
143Increased serum pyruvate (HP:0003542)1.69739783
144Abnormal number of incisors (HP:0011064)1.69313713
145Congenital stationary night blindness (HP:0007642)1.68248423
146Tracheoesophageal fistula (HP:0002575)1.67719300
147Horseshoe kidney (HP:0000085)1.67212029
148Slender long bone (HP:0003100)1.66489475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.69015419
2STK163.80878016
3BUB13.74696358
4NME23.60953297
5NUAK13.59219653
6EIF2AK13.01506929
7WEE12.94403415
8FRK2.83329492
9MAP4K22.64519119
10CDC72.58949408
11TLK12.42318580
12SRPK12.37924103
13VRK12.32334360
14ACVR1B2.29297775
15ZAK2.17924065
16IRAK32.08525485
17TAF12.07894691
18PLK41.98955473
19EIF2AK31.98905315
20IRAK41.88793573
21MST41.85935366
22BRSK21.85409312
23OXSR11.83736081
24MKNK11.80479588
25CCNB11.76666666
26PIM21.71556126
27NEK21.66400147
28PBK1.64447485
29MKNK21.61329621
30BMPR1B1.60831048
31RPS6KA41.59098486
32BCKDK1.51645424
33GRK11.48574064
34DYRK31.46403661
35TRIM281.45262235
36EIF2AK21.42716813
37PLK11.42011335
38ATR1.38957211
39AURKB1.38415344
40TEC1.37346323
41TTK1.33929765
42CDK71.32955517
43CDK81.31909284
44FLT31.31529980
45WNK31.22608162
46MAP4K11.20075262
47CSNK1G31.18230180
48BRSK11.15574411
49WNK41.13125310
50STK41.12811725
51TAOK31.12148879
52PASK1.09315893
53AURKA1.08078609
54TAOK21.07081674
55CSNK1G11.03106443
56TXK1.02865106
57KDR1.02858625
58CDK191.01812232
59BCR0.97977098
60PDK20.97751037
61BTK0.96649365
62CSNK1G20.95711860
63TSSK60.95593444
64DAPK10.93611376
65PIM10.92927198
66KIT0.88666729
67NME10.87874601
68NEK90.86926273
69MAP3K110.86636639
70CHEK20.83992898
71CSNK1A1L0.83661901
72MUSK0.82989586
73NEK10.81873033
74MAPKAPK50.80585253
75CDK40.79548166
76BRAF0.76626658
77INSRR0.75973049
78RPS6KA50.75528529
79TNK20.75441793
80TGFBR10.74706637
81CSNK2A10.73891986
82RPS6KB20.72770406
83YES10.70465865
84IKBKB0.69856731
85MAP2K30.69478833
86PLK30.69167653
87BLK0.65072143
88CLK10.64445481
89SCYL20.63342978
90ADRBK20.61499763
91MAPKAPK30.60603670
92TYK20.59829955
93IKBKE0.58017314
94PINK10.57162305
95CHEK10.57005584
96ATM0.55182100
97JAK30.54475784
98TESK20.54200863
99TIE10.53952558
100CSNK2A20.53474549
101MYLK0.52810217
102TNIK0.52763909
103MAP3K80.51775305
104LYN0.51037107
105MAP2K70.50447733
106MAP2K60.49920379
107STK240.49783216
108STK390.49617002
109MAP3K120.49074660
110NLK0.48796256
111MAP3K100.46234865
112MAP3K40.45524598
113ZAP700.45399534
114SYK0.44586942
115OBSCN0.44149517
116ADRBK10.42793204
117BRD40.42098635
118ERBB30.42041812
119MAPK110.41479170
120CDK20.41217890
121CHUK0.40870722
122STK38L0.39999762
123RPS6KA60.38925582
124DYRK20.38462640
125PLK20.38308548
126LIMK10.37564833
127CDK30.37560497
128ABL20.37465724
129RPS6KC10.36934700
130RPS6KL10.36934700
131STK100.35861758
132CSNK1A10.35589671
133MAP3K140.34960505
134PRKCQ0.33633176
135PIK3CG0.33585682
136GRK50.31538811
137STK30.31066595
138ITK0.28511621
139RAF10.26070834
140PHKG20.25681470
141PHKG10.25681470

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.15694739
2Ribosome_Homo sapiens_hsa030104.05840391
3Mismatch repair_Homo sapiens_hsa034303.96308654
4Base excision repair_Homo sapiens_hsa034103.28958697
5Homologous recombination_Homo sapiens_hsa034403.15157199
6RNA polymerase_Homo sapiens_hsa030203.08412145
7Proteasome_Homo sapiens_hsa030503.06295353
8Pyrimidine metabolism_Homo sapiens_hsa002402.79203674
9Spliceosome_Homo sapiens_hsa030402.74320734
10Nucleotide excision repair_Homo sapiens_hsa034202.66700219
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60403500
12One carbon pool by folate_Homo sapiens_hsa006702.56832423
13Fanconi anemia pathway_Homo sapiens_hsa034602.41587134
14Cell cycle_Homo sapiens_hsa041102.02375034
15RNA transport_Homo sapiens_hsa030131.97948716
16Non-homologous end-joining_Homo sapiens_hsa034501.93639064
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85716128
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80480586
19RNA degradation_Homo sapiens_hsa030181.73401771
20Parkinsons disease_Homo sapiens_hsa050121.67103557
21Protein export_Homo sapiens_hsa030601.66027146
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63272430
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.58215313
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57444748
25Fatty acid elongation_Homo sapiens_hsa000621.57226496
26Oxidative phosphorylation_Homo sapiens_hsa001901.55207333
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54951742
28Purine metabolism_Homo sapiens_hsa002301.53496113
29Basal transcription factors_Homo sapiens_hsa030221.51695226
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37775893
31Folate biosynthesis_Homo sapiens_hsa007901.35633821
32* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34344702
33Huntingtons disease_Homo sapiens_hsa050161.31306148
34Butanoate metabolism_Homo sapiens_hsa006501.25197805
35Systemic lupus erythematosus_Homo sapiens_hsa053221.19008101
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17522771
37p53 signaling pathway_Homo sapiens_hsa041151.15813458
38Sulfur relay system_Homo sapiens_hsa041221.08743952
39Nitrogen metabolism_Homo sapiens_hsa009101.06995540
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04300577
41Herpes simplex infection_Homo sapiens_hsa051681.01924829
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.01677499
43Caffeine metabolism_Homo sapiens_hsa002320.98541542
44Tryptophan metabolism_Homo sapiens_hsa003800.97934336
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93225599
46Phototransduction_Homo sapiens_hsa047440.89773860
47Primary immunodeficiency_Homo sapiens_hsa053400.85699700
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84513575
49Alzheimers disease_Homo sapiens_hsa050100.84401818
50Epstein-Barr virus infection_Homo sapiens_hsa051690.80175256
51mRNA surveillance pathway_Homo sapiens_hsa030150.79795982
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79178712
53Fatty acid metabolism_Homo sapiens_hsa012120.78951788
54Linoleic acid metabolism_Homo sapiens_hsa005910.76861435
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.76140855
56Pentose phosphate pathway_Homo sapiens_hsa000300.72730247
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71962142
58Selenocompound metabolism_Homo sapiens_hsa004500.71184301
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.69224813
60Sulfur metabolism_Homo sapiens_hsa009200.68508047
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.68378739
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66973002
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64418936
64N-Glycan biosynthesis_Homo sapiens_hsa005100.64114709
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63173372
66Glutathione metabolism_Homo sapiens_hsa004800.60736274
67Antigen processing and presentation_Homo sapiens_hsa046120.60580271
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59646873
69Retinol metabolism_Homo sapiens_hsa008300.59154195
70Chemical carcinogenesis_Homo sapiens_hsa052040.58954625
71Measles_Homo sapiens_hsa051620.58778292
72Metabolic pathways_Homo sapiens_hsa011000.58736787
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58587559
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57001526
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54862730
76Legionellosis_Homo sapiens_hsa051340.54407077
77Arachidonic acid metabolism_Homo sapiens_hsa005900.53377415
78Vitamin B6 metabolism_Homo sapiens_hsa007500.53307300
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.50758682
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50608260
81Carbon metabolism_Homo sapiens_hsa012000.48171262
82Biosynthesis of amino acids_Homo sapiens_hsa012300.47873931
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.47312934
84Hematopoietic cell lineage_Homo sapiens_hsa046400.46935090
85Allograft rejection_Homo sapiens_hsa053300.45824756
86Tyrosine metabolism_Homo sapiens_hsa003500.44856163
87Galactose metabolism_Homo sapiens_hsa000520.44728013
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43275242
89Viral carcinogenesis_Homo sapiens_hsa052030.42938376
90Peroxisome_Homo sapiens_hsa041460.41954891
91Olfactory transduction_Homo sapiens_hsa047400.40068440
92beta-Alanine metabolism_Homo sapiens_hsa004100.39654531
93HTLV-I infection_Homo sapiens_hsa051660.38727446
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37178880
95Ether lipid metabolism_Homo sapiens_hsa005650.36914911
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.36158384
97Apoptosis_Homo sapiens_hsa042100.35763340
98Steroid biosynthesis_Homo sapiens_hsa001000.34734322
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34646545
100Asthma_Homo sapiens_hsa053100.34245724
101Arginine and proline metabolism_Homo sapiens_hsa003300.34142658
102Regulation of autophagy_Homo sapiens_hsa041400.33956406
103Thyroid cancer_Homo sapiens_hsa052160.33280511
104Other glycan degradation_Homo sapiens_hsa005110.32844190
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32394670
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31987304
107Fructose and mannose metabolism_Homo sapiens_hsa000510.31679857
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30527524
109Influenza A_Homo sapiens_hsa051640.29712936
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29537642
111Cardiac muscle contraction_Homo sapiens_hsa042600.28953276
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28471528
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28236487
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27370987
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26901854
116Graft-versus-host disease_Homo sapiens_hsa053320.26142333
117Oocyte meiosis_Homo sapiens_hsa041140.23393709
118Leishmaniasis_Homo sapiens_hsa051400.23381558
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22674146
120Alcoholism_Homo sapiens_hsa050340.21963856
121Hepatitis B_Homo sapiens_hsa051610.20801222
122Propanoate metabolism_Homo sapiens_hsa006400.19813798
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19348542
124Small cell lung cancer_Homo sapiens_hsa052220.18890317
125Vitamin digestion and absorption_Homo sapiens_hsa049770.17638271
126Autoimmune thyroid disease_Homo sapiens_hsa053200.16419250
127Pyruvate metabolism_Homo sapiens_hsa006200.16084704
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15529760
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15079839
130Fatty acid degradation_Homo sapiens_hsa000710.14703521
131Acute myeloid leukemia_Homo sapiens_hsa052210.13501169
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.13385713
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12852742

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »