FXR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.15045836
2nuclear pore organization (GO:0006999)5.95195279
3pore complex assembly (GO:0046931)4.59609228
4mitotic sister chromatid cohesion (GO:0007064)4.54903656
5piRNA metabolic process (GO:0034587)4.33948449
6DNA replication-dependent nucleosome assembly (GO:0006335)4.20387625
7DNA replication-dependent nucleosome organization (GO:0034723)4.20387625
8chaperone-mediated protein complex assembly (GO:0051131)4.06736578
9fusion of sperm to egg plasma membrane (GO:0007342)4.02136411
10synaptonemal complex assembly (GO:0007130)3.99355675
11binding of sperm to zona pellucida (GO:0007339)3.96056969
12sarcoplasmic reticulum calcium ion transport (GO:0070296)3.93246987
13regulation of posttranscriptional gene silencing (GO:0060147)3.92667842
14regulation of gene silencing by miRNA (GO:0060964)3.92667842
15regulation of gene silencing by RNA (GO:0060966)3.92667842
16synaptonemal complex organization (GO:0070193)3.89894277
17sperm-egg recognition (GO:0035036)3.88636494
18regulation of histone H3-K9 methylation (GO:0051570)3.88122963
19regulation of RNA export from nucleus (GO:0046831)3.84228940
20mitotic nuclear envelope disassembly (GO:0007077)3.82050583
21mitotic chromosome condensation (GO:0007076)3.79233475
22male meiosis (GO:0007140)3.75583056
23heterochromatin organization (GO:0070828)3.72620825
24regulation of centriole replication (GO:0046599)3.70018307
25mitotic metaphase plate congression (GO:0007080)3.69452592
26positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.64197369
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.64197369
28positive regulation of mitotic sister chromatid separation (GO:1901970)3.64197369
29membrane disassembly (GO:0030397)3.61245011
30nuclear envelope disassembly (GO:0051081)3.61245011
31protein localization to kinetochore (GO:0034501)3.60297256
32protein localization to chromosome, centromeric region (GO:0071459)3.59214406
33monoubiquitinated protein deubiquitination (GO:0035520)3.56629060
34skeletal muscle contraction (GO:0003009)3.56044633
35negative regulation of DNA repair (GO:0045738)3.55263318
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.55118710
37positive regulation of chromosome segregation (GO:0051984)3.54526866
38microtubule depolymerization (GO:0007019)3.51357986
39DNA unwinding involved in DNA replication (GO:0006268)3.47484078
40regulation of mitotic spindle organization (GO:0060236)3.46904169
41regulation of spindle organization (GO:0090224)3.42960650
42metaphase plate congression (GO:0051310)3.42220923
43pre-miRNA processing (GO:0031054)3.41761119
44cell-cell recognition (GO:0009988)3.40501955
45chromosome condensation (GO:0030261)3.39496581
46establishment of integrated proviral latency (GO:0075713)3.36474019
47notochord development (GO:0030903)3.35126875
48muscle filament sliding (GO:0030049)3.31720681
49actin-myosin filament sliding (GO:0033275)3.31720681
50IMP metabolic process (GO:0046040)3.31482434
51acrosome assembly (GO:0001675)3.30656056
52chromatin assembly (GO:0031497)3.30207094
53mitotic sister chromatid segregation (GO:0000070)3.30093384
54sister chromatid segregation (GO:0000819)3.29590354
55paraxial mesoderm development (GO:0048339)3.28706108
56regulation of centrosome cycle (GO:0046605)3.25350410
57actin filament-based movement (GO:0030048)3.25089179
58chromosome organization involved in meiosis (GO:0070192)3.23717070
59histone exchange (GO:0043486)3.22718783
60cilium or flagellum-dependent cell motility (GO:0001539)3.21947850
61negative regulation of histone methylation (GO:0031061)3.20779273
62gene silencing by RNA (GO:0031047)3.20572179
63IMP biosynthetic process (GO:0006188)3.18440681
64regulation of helicase activity (GO:0051095)3.18175333
65sperm motility (GO:0030317)3.16527872
66NLS-bearing protein import into nucleus (GO:0006607)3.16381388
67regulation of sister chromatid cohesion (GO:0007063)3.14808524
68negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.13507048
69spermatid development (GO:0007286)3.13488540
70myofibril assembly (GO:0030239)3.12635589
71DNA packaging (GO:0006323)3.12103751
72regulation of chromosome segregation (GO:0051983)3.09518347
73regulation of meiosis I (GO:0060631)3.07356952
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06163207
75formation of translation preinitiation complex (GO:0001731)3.04394277
76meiotic nuclear division (GO:0007126)3.04208076
77sarcomere organization (GO:0045214)3.02762696
78DNA methylation involved in gamete generation (GO:0043046)3.02383879
79histone H2A monoubiquitination (GO:0035518)3.01513390
80plasma membrane fusion (GO:0045026)3.00530959
81cell wall macromolecule metabolic process (GO:0044036)3.00062508
82cell wall macromolecule catabolic process (GO:0016998)3.00062508
83multicellular organism reproduction (GO:0032504)2.99644443
84kinetochore organization (GO:0051383)2.98253153
85protein K6-linked ubiquitination (GO:0085020)2.98107545
86DNA geometric change (GO:0032392)2.96854481
87DNA duplex unwinding (GO:0032508)2.95695333
88protein localization to chromosome (GO:0034502)2.95092249
89chromatin remodeling at centromere (GO:0031055)2.93658184
90ribosome assembly (GO:0042255)2.91859053
91regulation of skeletal muscle contraction (GO:0014819)2.90710127
92response to muscle activity (GO:0014850)2.90469764
93sister chromatid cohesion (GO:0007062)2.88213040
94regulation of translational fidelity (GO:0006450)2.88201878
95establishment of chromosome localization (GO:0051303)2.87869354
96positive regulation of SMAD protein import into nucleus (GO:0060391)2.87484324
97DNA topological change (GO:0006265)2.85654628
98CENP-A containing nucleosome assembly (GO:0034080)2.85564734
99regulation of centrosome duplication (GO:0010824)2.83986497
100meiotic chromosome segregation (GO:0045132)2.83850384
101regulation of nucleobase-containing compound transport (GO:0032239)2.83590956
102attachment of spindle microtubules to kinetochore (GO:0008608)2.83321070
103nuclear envelope organization (GO:0006998)2.83113185
104regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82875449
105regulation of telomere maintenance via telomerase (GO:0032210)2.81033608
106cardiac myofibril assembly (GO:0055003)2.80544113
107actin-mediated cell contraction (GO:0070252)2.78152405
108DNA conformation change (GO:0071103)2.77414135
109spindle checkpoint (GO:0031577)2.77251617
110regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76957925
111spindle assembly involved in mitosis (GO:0090307)2.76783068
112non-recombinational repair (GO:0000726)2.76270037
113double-strand break repair via nonhomologous end joining (GO:0006303)2.76270037
114mitotic spindle checkpoint (GO:0071174)2.74198628
115DNA replication initiation (GO:0006270)2.73620087
116protein complex localization (GO:0031503)2.72213220
117regulation of DNA endoreduplication (GO:0032875)2.70971283
118plasma membrane repair (GO:0001778)2.70356200
119response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.65626996
120striated muscle contraction (GO:0006941)2.65307174
121negative regulation of potassium ion transmembrane transport (GO:1901380)2.62692719
122mitotic G2/M transition checkpoint (GO:0044818)2.58351802
123regulation of relaxation of muscle (GO:1901077)2.58226987
124hippo signaling (GO:0035329)2.55761429
125ATP-dependent chromatin remodeling (GO:0043044)2.51212388
126cellular protein complex localization (GO:0034629)2.50465961
127regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.48207919
128regulation of sister chromatid segregation (GO:0033045)2.48063179
129regulation of mitotic sister chromatid separation (GO:0010965)2.48063179
130regulation of mitotic sister chromatid segregation (GO:0033047)2.48063179
131negative regulation of chromosome segregation (GO:0051985)2.45752143
132DNA replication-independent nucleosome organization (GO:0034724)2.45539096
133DNA replication-independent nucleosome assembly (GO:0006336)2.45539096
134skeletal muscle fiber development (GO:0048741)2.45360841
135actomyosin structure organization (GO:0031032)2.45056746
136cardiac muscle cell development (GO:0055013)2.44462591
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.43582001
138negative regulation of sister chromatid segregation (GO:0033046)2.43582001
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.43582001
140negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.43582001
141negative regulation of mitotic sister chromatid segregation (GO:0033048)2.43582001
142otic vesicle formation (GO:0030916)2.41377686
143mRNA stabilization (GO:0048255)2.40798987
144RNA stabilization (GO:0043489)2.40798987
145mitotic G2 DNA damage checkpoint (GO:0007095)2.40627905
146adult heart development (GO:0007512)2.40029661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.84100626
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.34406208
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.77710988
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84453205
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.51839538
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.36237477
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.25175318
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05013646
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.85831953
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64196609
11AR_21909140_ChIP-Seq_LNCAP_Human2.57467607
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.37371589
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30469218
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28976416
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15767239
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15302257
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15302257
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15302257
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06044995
20MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97590235
21E2F1_21310950_ChIP-Seq_MCF-7_Human1.93519767
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93453749
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90545084
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.84793038
25* WT1_19549856_ChIP-ChIP_CCG9911_Human1.77667412
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.76308045
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76304364
28SOX2_18555785_ChIP-Seq_MESCs_Mouse1.73482163
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72292331
30* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.70161279
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.69941860
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69232389
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67665406
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65594662
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63717819
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61547207
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.57411387
38XRN2_22483619_ChIP-Seq_HELA_Human1.56852918
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56738418
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54334997
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52927990
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51673732
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.51419602
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50990942
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.50739601
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48143283
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48134352
48TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46703867
49* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42290948
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.37560708
51ELK1_19687146_ChIP-ChIP_HELA_Human1.37390608
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37130594
53NANOG_21062744_ChIP-ChIP_HESCs_Human1.35115662
54EWS_26573619_Chip-Seq_HEK293_Human1.30562280
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29634136
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29503968
57VDR_23849224_ChIP-Seq_CD4+_Human1.28537981
58CLOCK_20551151_ChIP-Seq_293T_Human1.27118158
59ZNF263_19887448_ChIP-Seq_K562_Human1.27023441
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.25919402
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25587801
62FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24889489
63SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.23860680
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23358361
65TTF2_22483619_ChIP-Seq_HELA_Human1.22763173
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20945084
67KDM5A_27292631_Chip-Seq_BREAST_Human1.20711659
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18146842
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13922333
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13363722
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.13081774
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12821340
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12794822
74NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12435815
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11849941
76SOX9_26525672_Chip-Seq_HEART_Mouse1.10959083
77SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10292790
78DCP1A_22483619_ChIP-Seq_HELA_Human1.09779978
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09580838
80GATA4_21415370_ChIP-Seq_HL-1_Mouse1.08600558
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08449563
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07564279
83NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06622174
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.06329762
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06095297
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05780447
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05308978
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05242950
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04621015
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04255569
91FOXP3_21729870_ChIP-Seq_TREG_Human1.03694096
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02128759
93SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01520300
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00134446
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99902624
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99609055
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99522185
98POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99185052
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98431590
100NANOG_18692474_ChIP-Seq_MESCs_Mouse0.98260129
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95731557
102* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95083881
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94976998
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94819289
105FUS_26573619_Chip-Seq_HEK293_Human0.93873622
106ISL1_27105846_Chip-Seq_CPCs_Mouse0.92976463
107FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91840950
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91774255
109CHD1_26751641_Chip-Seq_LNCaP_Human0.91062360
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90918856
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90078722
112TAF15_26573619_Chip-Seq_HEK293_Human0.89396960
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89386184
114TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89171340
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88903684
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88903646
117TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88835078
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87678227
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.87297948
120YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86950658
121EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85947148
122TFEB_21752829_ChIP-Seq_HELA_Human0.85702811
123GABP_19822575_ChIP-Seq_HepG2_Human0.85570229
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84735831
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84523554
126PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84272675
127TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.84176733
128NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83113441
129POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.83010327
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82814996
131MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.81825227
132* NANOG_16153702_ChIP-ChIP_HESCs_Human0.81544738
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.80207053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.29781065
2MP0010094_abnormal_chromosome_stability2.98223853
3MP0008877_abnormal_DNA_methylation2.80653503
4MP0008057_abnormal_DNA_replication2.69885239
5MP0004957_abnormal_blastocyst_morpholog2.67536180
6MP0003111_abnormal_nucleus_morphology2.61942512
7MP0003077_abnormal_cell_cycle2.53788740
8MP0004084_abnormal_cardiac_muscle2.38544296
9MP0003693_abnormal_embryo_hatching2.37396529
10MP0010352_gastrointestinal_tract_polyps2.26082486
11MP0003646_muscle_fatigue2.23295397
12MP0004145_abnormal_muscle_electrophysio2.22175967
13MP0001730_embryonic_growth_arrest2.17585152
14MP0003950_abnormal_plasma_membrane2.15376311
15MP0005623_abnormal_meninges_morphology2.13601543
16MP0004036_abnormal_muscle_relaxation2.02103409
17MP0000749_muscle_degeneration2.00210276
18MP0004233_abnormal_muscle_weight1.99499057
19MP0003123_paternal_imprinting1.97820471
20MP0000751_myopathy1.96025905
21MP0010307_abnormal_tumor_latency1.95226248
22MP0003705_abnormal_hypodermis_morpholog1.92356471
23MP0001929_abnormal_gametogenesis1.88770260
24MP0000750_abnormal_muscle_regeneration1.82074051
25MP0008932_abnormal_embryonic_tissue1.78022660
26MP0008058_abnormal_DNA_repair1.77828400
27MP0004197_abnormal_fetal_growth/weight/1.77357290
28MP0002084_abnormal_developmental_patter1.76951634
29MP0002269_muscular_atrophy1.74244343
30* MP0004087_abnormal_muscle_fiber1.70838752
31MP0001672_abnormal_embryogenesis/_devel1.70667648
32MP0005380_embryogenesis_phenotype1.70667648
33* MP0000733_abnormal_muscle_development1.70499962
34MP0002106_abnormal_muscle_physiology1.69595408
35MP0003567_abnormal_fetal_cardiomyocyte1.68079947
36MP0000350_abnormal_cell_proliferation1.67235274
37MP0000747_muscle_weakness1.66052092
38MP0003698_abnormal_male_reproductive1.64798707
39* MP0002210_abnormal_sex_determination1.61729808
40MP0003806_abnormal_nucleotide_metabolis1.60705164
41MP0001697_abnormal_embryo_size1.60318909
42MP0008007_abnormal_cellular_replicative1.60090190
43MP0002085_abnormal_embryonic_tissue1.59536254
44MP0003984_embryonic_growth_retardation1.56380788
45MP0009697_abnormal_copulation1.55295963
46MP0002088_abnormal_embryonic_growth/wei1.54162424
47MP0005076_abnormal_cell_differentiation1.52688705
48MP0000759_abnormal_skeletal_muscle1.43793331
49MP0004185_abnormal_adipocyte_glucose1.42283159
50MP0000537_abnormal_urethra_morphology1.40603904
51MP0002086_abnormal_extraembryonic_tissu1.40388917
52MP0005369_muscle_phenotype1.39393933
53MP0003121_genomic_imprinting1.37002757
54* MP0001145_abnormal_male_reproductive1.36924962
55MP0003937_abnormal_limbs/digits/tail_de1.36655314
56MP0001293_anophthalmia1.36390657
57MP0002080_prenatal_lethality1.29709341
58MP0002837_dystrophic_cardiac_calcinosis1.29679436
59MP0003890_abnormal_embryonic-extraembry1.28089014
60MP0002653_abnormal_ependyma_morphology1.27492508
61* MP0010630_abnormal_cardiac_muscle1.27336949
62MP0008438_abnormal_cutaneous_collagen1.21888457
63MP0001286_abnormal_eye_development1.19959573
64MP0003221_abnormal_cardiomyocyte_apopto1.19571307
65MP0010030_abnormal_orbit_morphology1.18649757
66MP0003566_abnormal_cell_adhesion1.17743748
67* MP0000653_abnormal_sex_gland1.17172844
68MP0002233_abnormal_nose_morphology1.15249954
69MP0000762_abnormal_tongue_morphology1.14565848
70MP0005330_cardiomyopathy1.13993899
71MP0005666_abnormal_adipose_tissue1.12060879
72MP0001346_abnormal_lacrimal_gland1.11908368
73MP0003755_abnormal_palate_morphology1.10401595
74MP0002877_abnormal_melanocyte_morpholog1.09505014
75MP0000566_synostosis1.07955230
76MP0005620_abnormal_muscle_contractility1.07316558
77MP0009053_abnormal_anal_canal1.06587174
78MP0004215_abnormal_myocardial_fiber1.04709382
79MP0006292_abnormal_olfactory_placode1.03225267
80MP0002938_white_spotting1.02108481
81MP0000428_abnormal_craniofacial_morphol1.01233442
82MP0005451_abnormal_body_composition1.01053237
83MP0002108_abnormal_muscle_morphology1.00758343
84MP0003136_yellow_coat_color1.00601831
85MP0002161_abnormal_fertility/fecundity0.99984332
86MP0003935_abnormal_craniofacial_develop0.99893931
87MP0003786_premature_aging0.98846381
88MP0009672_abnormal_birth_weight0.98096920
89MP0009703_decreased_birth_body0.96651157
90MP0004133_heterotaxia0.96260587
91MP0006138_congestive_heart_failure0.95362557
92MP0002009_preneoplasia0.95035214
93MP0002234_abnormal_pharynx_morphology0.91996884
94MP0002697_abnormal_eye_size0.90726851
95MP0009250_abnormal_appendicular_skeleto0.87474861
96MP0000432_abnormal_head_morphology0.87237167
97MP0002925_abnormal_cardiovascular_devel0.86512182
98* MP0000266_abnormal_heart_morphology0.86157527
99MP0008775_abnormal_heart_ventricle0.84894164
100MP0003861_abnormal_nervous_system0.84788014
101MP0004272_abnormal_basement_membrane0.84409174
102MP0003119_abnormal_digestive_system0.83477398
103MP0001849_ear_inflammation0.83434759
104MP0002114_abnormal_axial_skeleton0.83151733
105MP0010234_abnormal_vibrissa_follicle0.82640072
106MP0002092_abnormal_eye_morphology0.82311141
107MP0002111_abnormal_tail_morphology0.82265481
108MP0003718_maternal_effect0.82019719
109MP0004130_abnormal_muscle_cell0.81987394
110MP0002127_abnormal_cardiovascular_syste0.81423835
111MP0003315_abnormal_perineum_morphology0.81347909
112MP0001299_abnormal_eye_distance/0.79880836
113MP0000313_abnormal_cell_death0.78647380
114MP0001661_extended_life_span0.77648263
115MP0005187_abnormal_penis_morphology0.77418228
116MP0003385_abnormal_body_wall0.76950391
117MP0002972_abnormal_cardiac_muscle0.76887497
118MP0001915_intracranial_hemorrhage0.76159663
119MP0003941_abnormal_skin_development0.75774882
120MP0005375_adipose_tissue_phenotype0.75367677
121MP0005248_abnormal_Harderian_gland0.75300952
122MP0005385_cardiovascular_system_phenoty0.74945680
123MP0001544_abnormal_cardiovascular_syste0.74945680
124MP0003942_abnormal_urinary_system0.74254230
125MP0003115_abnormal_respiratory_system0.73775585
126MP0000534_abnormal_ureter_morphology0.73319618
127MP0000579_abnormal_nail_morphology0.73219091
128* MP0002081_perinatal_lethality0.73124004

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.03537957
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.96883884
3Exercise-induced muscle cramps (HP:0003710)4.62420668
4Nemaline bodies (HP:0003798)4.58174884
5Type 1 muscle fiber predominance (HP:0003803)3.89702979
6Muscle fiber splitting (HP:0003555)3.82138148
7Hyporeflexia of lower limbs (HP:0002600)3.79861813
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.62814754
9Ependymoma (HP:0002888)3.53914855
10Difficulty running (HP:0009046)3.50582807
11Exercise-induced myalgia (HP:0003738)3.42681980
12Increased connective tissue (HP:0009025)3.36008089
13Distal arthrogryposis (HP:0005684)3.29499342
14Muscle hypertrophy of the lower extremities (HP:0008968)3.29396980
15Round ear (HP:0100830)3.27788196
16Difficulty climbing stairs (HP:0003551)3.19287597
17Ulnar deviation of the wrist (HP:0003049)3.12756096
18Calf muscle hypertrophy (HP:0008981)3.07539214
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.01438562
20Absent/shortened dynein arms (HP:0200106)3.01438562
21Abnormality of the astrocytes (HP:0100707)2.99026775
22Astrocytoma (HP:0009592)2.99026775
23Calcaneovalgus deformity (HP:0001848)2.77072790
24Rhabdomyolysis (HP:0003201)2.63529602
25Abnormality of the labia minora (HP:0012880)2.61573761
26Centrally nucleated skeletal muscle fibers (HP:0003687)2.59543987
27Myoglobinuria (HP:0002913)2.58945769
28Selective tooth agenesis (HP:0001592)2.58876970
29Deformed tarsal bones (HP:0008119)2.55436801
30Pelvic girdle muscle weakness (HP:0003749)2.53817802
31Shoulder girdle muscle weakness (HP:0003547)2.52662371
32Abnormality of the calcaneus (HP:0008364)2.51470375
33Neoplasm of the oral cavity (HP:0100649)2.50680526
34Biliary tract neoplasm (HP:0100574)2.48650534
35Medulloblastoma (HP:0002885)2.47523424
36Colon cancer (HP:0003003)2.43399210
37Myopathic facies (HP:0002058)2.42780043
38EMG: myopathic abnormalities (HP:0003458)2.42207929
39Glioma (HP:0009733)2.35714262
40Hypoplastic ischia (HP:0003175)2.34811265
41Abnormality of the calf musculature (HP:0001430)2.34469511
42Supernumerary spleens (HP:0009799)2.31847994
43Abnormality of the musculature of the pelvis (HP:0001469)2.30643120
44Abnormality of the hip-girdle musculature (HP:0001445)2.30643120
45Nephroblastoma (Wilms tumor) (HP:0002667)2.29241860
46Rimmed vacuoles (HP:0003805)2.28837620
47Limb-girdle muscle weakness (HP:0003325)2.27557366
48Volvulus (HP:0002580)2.27326028
49Abnormality of the left ventricular outflow tract (HP:0011103)2.24299006
50Subaortic stenosis (HP:0001682)2.24299006
51Embryonal renal neoplasm (HP:0011794)2.24194086
52Popliteal pterygium (HP:0009756)2.23322715
53Rhabdomyosarcoma (HP:0002859)2.22557583
54EMG: neuropathic changes (HP:0003445)2.18034345
55Malignant hyperthermia (HP:0002047)2.15910288
56Abnormal finger flexion creases (HP:0006143)2.13050357
57Aplasia/hypoplasia of the humerus (HP:0006507)2.11186395
58Chromsome breakage (HP:0040012)2.10559669
59Spinal rigidity (HP:0003306)2.10392967
60Short humerus (HP:0005792)2.10266204
61Missing ribs (HP:0000921)2.09243474
62Bell-shaped thorax (HP:0001591)2.08425391
63Absent phalangeal crease (HP:0006109)2.08356782
64Sudden death (HP:0001699)2.06690819
65Impulsivity (HP:0100710)2.05303062
66Papillary thyroid carcinoma (HP:0002895)2.03203075
67Abnormality of the ischium (HP:0003174)2.00234987
68Wrist flexion contracture (HP:0001239)1.97080958
69Abnormal respiratory motile cilium physiology (HP:0012261)1.96985165
70Long clavicles (HP:0000890)1.94711744
71Progressive muscle weakness (HP:0003323)1.93809487
72Increased nuchal translucency (HP:0010880)1.93407505
73Neoplasm of striated muscle (HP:0009728)1.92405325
74Absent radius (HP:0003974)1.87748236
75Hip contracture (HP:0003273)1.86945390
76Abnormality of the shoulder girdle musculature (HP:0001435)1.85910730
77Proximal placement of thumb (HP:0009623)1.85402091
78Deviation of the thumb (HP:0009603)1.84073371
79Scapular winging (HP:0003691)1.82259949
80Proximal amyotrophy (HP:0007126)1.81399164
81Supernumerary ribs (HP:0005815)1.80999787
82Fetal akinesia sequence (HP:0001989)1.79892872
83Cystic hygroma (HP:0000476)1.79563679
84Areflexia of lower limbs (HP:0002522)1.79098009
85Generalized muscle weakness (HP:0003324)1.77240954
86Heterotopia (HP:0002282)1.76348479
87Distal lower limb muscle weakness (HP:0009053)1.76104210
88Neck muscle weakness (HP:0000467)1.75274455
89Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74468539
90Male infertility (HP:0003251)1.74400962
91Hyperkalemia (HP:0002153)1.74049990
92Absent forearm bone (HP:0003953)1.73006117
93Aplasia involving forearm bones (HP:0009822)1.73006117
94Supernumerary bones of the axial skeleton (HP:0009144)1.72323592
95Bundle branch block (HP:0011710)1.71387064
96Increased variability in muscle fiber diameter (HP:0003557)1.71373854
97Abnormal respiratory epithelium morphology (HP:0012253)1.71236017
98Abnormal respiratory motile cilium morphology (HP:0005938)1.71236017
99Ankle contracture (HP:0006466)1.70389269
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70011624
101Abnormality of skeletal muscle fiber size (HP:0012084)1.69575167
102Neoplasm of the small intestine (HP:0100833)1.69440188
103Abnormality of chromosome stability (HP:0003220)1.69364979
104Abnormality of the septum pellucidum (HP:0007375)1.69041851
105Agnosia (HP:0010524)1.68117040
106Ectopic kidney (HP:0000086)1.67983975
107Thin ribs (HP:0000883)1.67808197
108Hepatoblastoma (HP:0002884)1.66841722
109Neoplasm of the rectum (HP:0100743)1.66825129
110Mildly elevated creatine phosphokinase (HP:0008180)1.66577488
111Abnormality of the salivary glands (HP:0010286)1.66333791
112Limb-girdle muscle atrophy (HP:0003797)1.66259418
113Chronic bronchitis (HP:0004469)1.66007191
114Ovarian neoplasm (HP:0100615)1.65371497
115Pterygium (HP:0001059)1.64908272
116Breech presentation (HP:0001623)1.64837121
117Progressive external ophthalmoplegia (HP:0000590)1.64542273
118Muscle stiffness (HP:0003552)1.63383390
119Metaphyseal cupping (HP:0003021)1.63174268
120Gowers sign (HP:0003391)1.62987100
121Myotonia (HP:0002486)1.61637536
122Weak cry (HP:0001612)1.61576383
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.60796187
124Rhinitis (HP:0012384)1.60079381
125Frequent falls (HP:0002359)1.59530410
126Breast hypoplasia (HP:0003187)1.59453661
127Ventricular tachycardia (HP:0004756)1.58900524
128Metatarsus adductus (HP:0001840)1.56010336
129Dilated cardiomyopathy (HP:0001644)1.54314529
130Abnormal lung lobation (HP:0002101)1.53910402
131Cortical dysplasia (HP:0002539)1.50964344
132Ulnar deviation of finger (HP:0009465)1.48700840
133Absent septum pellucidum (HP:0001331)1.47653151
134Distal lower limb amyotrophy (HP:0008944)1.46316549
135Lower limb amyotrophy (HP:0007210)1.46183558
136Limited hip movement (HP:0008800)1.46005643
137Webbed neck (HP:0000465)1.45322637
138Multiple enchondromatosis (HP:0005701)1.44468060
139Abnormality of the neuromuscular junction (HP:0003398)1.41951869
140Fatigable weakness (HP:0003473)1.41951869
141Anal stenosis (HP:0002025)1.41825242
142Amniotic constriction ring (HP:0009775)1.41725095
143Abnormality of placental membranes (HP:0011409)1.41725095
144Septo-optic dysplasia (HP:0100842)1.41391045
145Narrow face (HP:0000275)1.40929204
146Lipoatrophy (HP:0100578)1.40866865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.37584807
2PDK44.37584807
3CDC73.46082068
4PDK22.89488475
5CDK122.83638811
6TTN2.80337312
7OBSCN2.78071955
8NEK12.72980855
9PNCK2.57632671
10WEE12.50038046
11TTK2.38346677
12NEK22.26023997
13TAF12.16275586
14LATS12.10251361
15TNIK1.91396901
16ICK1.79071061
17PKN21.62677071
18EPHA21.53543800
19RPS6KB21.52709629
20STK31.44954571
21TESK11.42233073
22PLK11.38591564
23EIF2AK31.33561516
24STK38L1.33496508
25SRPK11.33375959
26BUB11.33262105
27EEF2K1.32938453
28MKNK11.31957591
29CHEK11.30100366
30PLK41.29182349
31MET1.24269784
32PASK1.20212755
33CHEK21.19307359
34TSSK61.16189747
35PLK31.15784007
36BRD41.15060572
37AURKB1.12435564
38CAMK1G1.11813565
39ERBB31.11594925
40STK391.09862971
41LATS21.09645374
42ATR1.09311910
43EIF2AK11.04497082
44STK241.01874149
45CDK71.01546269
46TRIM281.01462927
47PRKD31.00708043
48ATM1.00572759
49MTOR0.99353754
50ZAK0.97333853
51BRSK20.95992807
52STK100.94609682
53CDK60.93171401
54CDK40.93122645
55MAP3K80.91253975
56STK40.88432043
57AKT30.87824219
58MST40.85938803
59MELK0.84933304
60PHKG20.83719242
61PHKG10.83719242
62MKNK20.81771827
63ALK0.81238610
64VRK20.80085002
65FLT30.79579917
66CSNK1D0.78268604
67MAP3K90.77828177
68CDK20.77252340
69WNK10.76589145
70PAK40.72183119
71CCNB10.70926211
72PAK20.70321365
73SCYL20.70098107
74ACVR1B0.69941583
75DYRK30.66380429
76EIF2AK20.65796028
77TGFBR10.64890335
78BRSK10.64837721
79CDK10.64661630
80CSNK1E0.64366705
81MAP3K100.63872333
82TYRO30.63671666
83AURKA0.61789436
84WNK40.60902563
85FGFR10.60579992
86PDGFRA0.60394301
87DMPK0.59507144
88KSR10.58630391
89BRAF0.56684549
90CAMK1D0.55968272
91MUSK0.55684783
92PLK20.54691688
93TLK10.54168107
94FGFR20.53778808
95PIK3CG0.53170501
96CASK0.52845509
97BMPR1B0.52766199
98NME10.52547247
99NLK0.51267540
100CSNK2A20.50191354
101TRPM70.49668300
102SMG10.49444632
103NEK90.48320275
104LIMK10.48083754
105MAP3K70.47975591
106PBK0.47824864
107CDK90.47382451
108PRKDC0.46428967
109ERBB40.45994472
110AKT20.42905762
111DDR20.42239090
112YES10.42011006
113RPS6KA50.42006617
114LRRK20.40232394
115MAPK100.39517059
116CDK80.38060573
117DYRK1B0.36582296
118RPS6KA40.36557609
119NTRK10.36328104
120BCR0.34907569
121PIM10.34169650
122PTK60.31684041
123MAPK140.31548297
124PDGFRB0.31225410
125GSK3B0.30708054
126PRKAA10.29880679
127MOS0.29862788
128ILK0.29854721
129PTK2B0.29822077
130BMX0.28997463

Predicted pathways (KEGG)

RankGene SetZ-score
1* RNA transport_Homo sapiens_hsa030133.39495048
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.28101592
3Mismatch repair_Homo sapiens_hsa034303.12709758
4DNA replication_Homo sapiens_hsa030302.73462039
5Spliceosome_Homo sapiens_hsa030402.66722317
6Cell cycle_Homo sapiens_hsa041102.66665302
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56834363
8mRNA surveillance pathway_Homo sapiens_hsa030152.42901370
9Basal transcription factors_Homo sapiens_hsa030222.25134638
10Nucleotide excision repair_Homo sapiens_hsa034202.18274929
11Homologous recombination_Homo sapiens_hsa034402.14435863
12Fanconi anemia pathway_Homo sapiens_hsa034602.14391301
13One carbon pool by folate_Homo sapiens_hsa006702.06763857
14Non-homologous end-joining_Homo sapiens_hsa034502.04350611
15RNA degradation_Homo sapiens_hsa030182.01328035
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.91206706
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87375912
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.77717248
19Systemic lupus erythematosus_Homo sapiens_hsa053221.77572005
20Oocyte meiosis_Homo sapiens_hsa041141.60374777
21RNA polymerase_Homo sapiens_hsa030201.57627006
22Proteasome_Homo sapiens_hsa030501.53115978
23p53 signaling pathway_Homo sapiens_hsa041151.50795752
24Base excision repair_Homo sapiens_hsa034101.49532014
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.44047485
26Carbon metabolism_Homo sapiens_hsa012001.38141557
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36276307
28Viral carcinogenesis_Homo sapiens_hsa052031.31918010
29Pyruvate metabolism_Homo sapiens_hsa006201.29192277
30Tight junction_Homo sapiens_hsa045301.28294499
31Adherens junction_Homo sapiens_hsa045201.28010236
32Biosynthesis of amino acids_Homo sapiens_hsa012301.26774345
33Ribosome_Homo sapiens_hsa030101.24076515
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22900125
35Circadian rhythm_Homo sapiens_hsa047101.22774139
36Hippo signaling pathway_Homo sapiens_hsa043901.22615001
37MicroRNAs in cancer_Homo sapiens_hsa052061.19340693
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19218566
39TGF-beta signaling pathway_Homo sapiens_hsa043501.18913560
40Propanoate metabolism_Homo sapiens_hsa006401.17753115
41Basal cell carcinoma_Homo sapiens_hsa052171.16991928
42Dilated cardiomyopathy_Homo sapiens_hsa054141.13985743
43Cardiac muscle contraction_Homo sapiens_hsa042601.12743726
44Selenocompound metabolism_Homo sapiens_hsa004501.11629300
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07836046
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07595909
47Vitamin B6 metabolism_Homo sapiens_hsa007501.05066317
48Small cell lung cancer_Homo sapiens_hsa052221.02904023
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.02271763
50Dorso-ventral axis formation_Homo sapiens_hsa043201.01259231
51Glucagon signaling pathway_Homo sapiens_hsa049221.00582484
52Hedgehog signaling pathway_Homo sapiens_hsa043401.00433865
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99828711
54Viral myocarditis_Homo sapiens_hsa054160.99731292
55Protein export_Homo sapiens_hsa030600.98718827
56Epstein-Barr virus infection_Homo sapiens_hsa051690.97917629
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94525912
58mTOR signaling pathway_Homo sapiens_hsa041500.92589255
59Pyrimidine metabolism_Homo sapiens_hsa002400.92568608
60Fatty acid biosynthesis_Homo sapiens_hsa000610.89906002
61Endometrial cancer_Homo sapiens_hsa052130.88868213
62ECM-receptor interaction_Homo sapiens_hsa045120.81160935
63Lysine degradation_Homo sapiens_hsa003100.80596869
64Huntingtons disease_Homo sapiens_hsa050160.78373907
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.77875745
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77269644
67Focal adhesion_Homo sapiens_hsa045100.77131641
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76907779
69Arginine biosynthesis_Homo sapiens_hsa002200.76199950
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76116482
71HTLV-I infection_Homo sapiens_hsa051660.74463319
72Antigen processing and presentation_Homo sapiens_hsa046120.74215998
73Proteoglycans in cancer_Homo sapiens_hsa052050.71323037
74Purine metabolism_Homo sapiens_hsa002300.70213211
75HIF-1 signaling pathway_Homo sapiens_hsa040660.67728721
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67263249
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64319129
78Pentose phosphate pathway_Homo sapiens_hsa000300.64023616
79Melanogenesis_Homo sapiens_hsa049160.63017252
80AMPK signaling pathway_Homo sapiens_hsa041520.62327493
81Alcoholism_Homo sapiens_hsa050340.60159320
82Thyroid cancer_Homo sapiens_hsa052160.59936373
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58423870
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58395227
85Renal cell carcinoma_Homo sapiens_hsa052110.57184974
86Prostate cancer_Homo sapiens_hsa052150.56805835
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55026244
88Pathways in cancer_Homo sapiens_hsa052000.54943797
89Wnt signaling pathway_Homo sapiens_hsa043100.54466260
90Glioma_Homo sapiens_hsa052140.53936322
91Pancreatic cancer_Homo sapiens_hsa052120.53594726
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53144951
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52285700
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51016660
95Linoleic acid metabolism_Homo sapiens_hsa005910.50946648
96Insulin signaling pathway_Homo sapiens_hsa049100.50030342
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49050510
98Colorectal cancer_Homo sapiens_hsa052100.47738884
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43963465
100ErbB signaling pathway_Homo sapiens_hsa040120.43692008
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43679436
102Notch signaling pathway_Homo sapiens_hsa043300.42191375
103Chronic myeloid leukemia_Homo sapiens_hsa052200.41988417
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41925048
105Non-small cell lung cancer_Homo sapiens_hsa052230.41552074
106Herpes simplex infection_Homo sapiens_hsa051680.41106762
107Steroid biosynthesis_Homo sapiens_hsa001000.39411626
108Fructose and mannose metabolism_Homo sapiens_hsa000510.39076384
109FoxO signaling pathway_Homo sapiens_hsa040680.38228610
110Oxytocin signaling pathway_Homo sapiens_hsa049210.37049459
111Melanoma_Homo sapiens_hsa052180.37043007
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36192687
113Axon guidance_Homo sapiens_hsa043600.35950771
114Bladder cancer_Homo sapiens_hsa052190.34687343
115Legionellosis_Homo sapiens_hsa051340.34249242
116Insulin resistance_Homo sapiens_hsa049310.33491987
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30907848
118Fatty acid metabolism_Homo sapiens_hsa012120.27776075
119Arginine and proline metabolism_Homo sapiens_hsa003300.27081492
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26789837
121Fatty acid degradation_Homo sapiens_hsa000710.25652196

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