FXR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.74003917
2pre-miRNA processing (GO:0031054)4.60019360
3sarcoplasmic reticulum calcium ion transport (GO:0070296)4.51985472
4plasma membrane repair (GO:0001778)4.48493794
5negative regulation of potassium ion transmembrane transport (GO:1901380)4.46750141
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.31627350
7regulation of translational termination (GO:0006449)4.18886000
8muscle filament sliding (GO:0030049)4.16126681
9actin-myosin filament sliding (GO:0033275)4.16126681
10regulation of gene silencing by RNA (GO:0060966)4.12224600
11regulation of posttranscriptional gene silencing (GO:0060147)4.12224600
12regulation of gene silencing by miRNA (GO:0060964)4.12224600
13heterochromatin organization (GO:0070828)4.11110962
14cerebellar granule cell differentiation (GO:0021707)4.02421585
15regulation of translational fidelity (GO:0006450)3.98359610
16regulation of hippo signaling (GO:0035330)3.97709229
17determination of adult lifespan (GO:0008340)3.86334243
18regulation of early endosome to late endosome transport (GO:2000641)3.85005027
19cytoskeletal anchoring at plasma membrane (GO:0007016)3.83539670
20peptidyl-lysine dimethylation (GO:0018027)3.82196736
21negative regulation of cell size (GO:0045792)3.76600119
22establishment of apical/basal cell polarity (GO:0035089)3.54166948
23positive regulation of synapse maturation (GO:0090129)3.50131026
24adherens junction assembly (GO:0034333)3.44004426
25mitotic G1 DNA damage checkpoint (GO:0031571)3.43315070
26actin-mediated cell contraction (GO:0070252)3.30010184
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28226436
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.23604634
29glutamate secretion (GO:0014047)3.23466883
30regulation of mammary gland epithelial cell proliferation (GO:0033599)3.22449288
31polarized epithelial cell differentiation (GO:0030859)3.21055192
32striated muscle contraction (GO:0006941)3.14836849
33DNA damage induced protein phosphorylation (GO:0006975)3.12251979
34negative regulation of histone methylation (GO:0031061)3.11696299
35cell-substrate adherens junction assembly (GO:0007045)3.09203703
36focal adhesion assembly (GO:0048041)3.09203703
37sodium ion export (GO:0071436)3.06972046
38NLS-bearing protein import into nucleus (GO:0006607)3.06739455
39regulation of short-term neuronal synaptic plasticity (GO:0048172)3.06442814
40paraxial mesoderm development (GO:0048339)3.03294516
41positive regulation of SMAD protein import into nucleus (GO:0060391)3.02647683
42establishment of monopolar cell polarity (GO:0061162)3.01201436
43establishment or maintenance of monopolar cell polarity (GO:0061339)3.01201436
44cell communication by electrical coupling (GO:0010644)3.01141780
45cellular potassium ion homeostasis (GO:0030007)3.00159770
46chromatin assembly (GO:0031497)2.96762994
47dopamine receptor signaling pathway (GO:0007212)2.95505792
48nuclear pore organization (GO:0006999)2.95096712
49mitotic G1/S transition checkpoint (GO:0044819)2.94487482
50nuclear pore complex assembly (GO:0051292)2.91898396
51negative regulation of organelle assembly (GO:1902116)2.91615560
52adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.90310495
53planar cell polarity pathway involved in neural tube closure (GO:0090179)2.88043072
54cell communication involved in cardiac conduction (GO:0086065)2.87175495
55anterior/posterior axis specification, embryo (GO:0008595)2.84198869
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.83809538
57cardiac myofibril assembly (GO:0055003)2.83625717
58creatine metabolic process (GO:0006600)2.83072992
59activation of protein kinase A activity (GO:0034199)2.81901721
60establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.81740620
61layer formation in cerebral cortex (GO:0021819)2.81616389
62histone H2A monoubiquitination (GO:0035518)2.79677428
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79177552
64artery development (GO:0060840)2.78831741
65protein targeting to plasma membrane (GO:0072661)2.77947101
66positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.77625101
67neuromuscular process controlling balance (GO:0050885)2.77462656
68peptidyl-arginine omega-N-methylation (GO:0035247)2.75510874
69cellular response to catecholamine stimulus (GO:0071870)2.75090525
70cellular response to monoamine stimulus (GO:0071868)2.75090525
71protein localization to endosome (GO:0036010)2.74706639
72actin filament-based movement (GO:0030048)2.74473645
73response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.73678673
74G1 DNA damage checkpoint (GO:0044783)2.73391104
75stress fiber assembly (GO:0043149)2.72990587
76apoptotic process involved in morphogenesis (GO:0060561)2.72247875
77establishment of mitochondrion localization (GO:0051654)2.69717903
78epithelial cell-cell adhesion (GO:0090136)2.69130703
79negative regulation of nucleotide catabolic process (GO:0030812)2.68836919
80positive regulation of myotube differentiation (GO:0010831)2.68728909
81response to parathyroid hormone (GO:0071107)2.67794767
82vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.67569317
83intracellular estrogen receptor signaling pathway (GO:0030520)2.67311841
84neuronal ion channel clustering (GO:0045161)2.67247599
85regulation of SMAD protein import into nucleus (GO:0060390)2.66458162
86regulation of synapse structural plasticity (GO:0051823)2.65831515
87sarcomere organization (GO:0045214)2.65821654
88peptidyl-tyrosine autophosphorylation (GO:0038083)2.65784135
89activation of Rac GTPase activity (GO:0032863)2.64866275
90regulation of synapse maturation (GO:0090128)2.63848891
91respiratory system process (GO:0003016)2.62208156
92cell-substrate junction assembly (GO:0007044)2.60694478
93regulation of NFAT protein import into nucleus (GO:0051532)2.60535994
94positive regulation of RNA splicing (GO:0033120)2.60365115
95regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59994728
96axon extension (GO:0048675)2.59431628
97stress granule assembly (GO:0034063)2.58694739
98semaphorin-plexin signaling pathway (GO:0071526)2.58636916
99actomyosin structure organization (GO:0031032)2.58581590
100spliceosomal tri-snRNP complex assembly (GO:0000244)2.56994349
101hippo signaling (GO:0035329)2.56151972
102negative regulation of catenin import into nucleus (GO:0035414)2.56035634
103skeletal muscle contraction (GO:0003009)2.55844421
104synaptic vesicle exocytosis (GO:0016079)2.55642697
105negative regulation of potassium ion transport (GO:0043267)2.55477290
106embryonic foregut morphogenesis (GO:0048617)2.54599123
107regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.53580955
108maternal placenta development (GO:0001893)2.53470940
109regulation of synaptic vesicle exocytosis (GO:2000300)2.53424373
110bundle of His cell to Purkinje myocyte communication (GO:0086069)2.53365286
111positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.52568632
112response to epidermal growth factor (GO:0070849)2.52337854
113positive regulation of histone deacetylation (GO:0031065)2.52089131
114regulation of glycogen (starch) synthase activity (GO:2000465)2.50921089
115positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.50359993
116trophectodermal cell differentiation (GO:0001829)2.48565606
117morphogenesis of an epithelial fold (GO:0060571)2.48202291
118folic acid-containing compound biosynthetic process (GO:0009396)2.48116066
119activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.47502212
120protein retention in ER lumen (GO:0006621)2.47098235
121nodal signaling pathway (GO:0038092)2.46895547
122peptidyl-arginine N-methylation (GO:0035246)2.46081598
123peptidyl-arginine methylation (GO:0018216)2.46081598
124regulation of actin filament-based movement (GO:1903115)2.46033649
125neuron remodeling (GO:0016322)2.45397295
126positive regulation of protein dephosphorylation (GO:0035307)2.44558191
127camera-type eye morphogenesis (GO:0048593)2.44378736
128mitochondrion transport along microtubule (GO:0047497)2.44077263
129establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.44077263
130glial cell proliferation (GO:0014009)2.43809314
131cell migration in hindbrain (GO:0021535)2.43456141
132RNA stabilization (GO:0043489)2.43363492
133mRNA stabilization (GO:0048255)2.43363492
134regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.43338429
135activation of MAPKKK activity (GO:0000185)2.42534033
136kidney mesenchyme development (GO:0072074)2.42387217
137regulation of tight junction assembly (GO:2000810)2.41492575
138regulation of ARF protein signal transduction (GO:0032012)2.40748589
139histone H4-K12 acetylation (GO:0043983)2.40426591
140negative regulation of fatty acid transport (GO:2000192)2.39714959
141cellular protein complex localization (GO:0034629)2.39662707
142chromatin silencing (GO:0006342)2.39455985
143neuron projection extension (GO:1990138)2.39164375
144positive regulation of nuclease activity (GO:0032075)2.38960675
145mating behavior (GO:0007617)2.38911487
146regulation of histone H3-K9 methylation (GO:0051570)2.38662876
147mitochondrial fusion (GO:0008053)2.38054042
148carnitine shuttle (GO:0006853)2.37937019
149gene silencing (GO:0016458)2.37815257
150G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.37530221
151hemidesmosome assembly (GO:0031581)2.36769241
152cardiac muscle contraction (GO:0060048)2.36021944
153establishment of nucleus localization (GO:0040023)2.35343637
154cardiac muscle hypertrophy (GO:0003300)2.34443814
155COPI coating of Golgi vesicle (GO:0048205)2.34408590
156Golgi transport vesicle coating (GO:0048200)2.34408590
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.34086545
158cell-cell junction maintenance (GO:0045217)2.33451194
159ventricular cardiac muscle cell action potential (GO:0086005)2.33373143
160regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.32638021
161establishment or maintenance of apical/basal cell polarity (GO:0035088)2.32430015
162establishment or maintenance of bipolar cell polarity (GO:0061245)2.32430015
163basement membrane organization (GO:0071711)2.32247645
164positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.31516785
165regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.31516785
166negative regulation of purine nucleotide catabolic process (GO:0033122)2.31345065
167positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.28666136
168myofibril assembly (GO:0030239)2.28638611
169regulation of ARF GTPase activity (GO:0032312)2.28423264
170synaptic vesicle maturation (GO:0016188)2.27404067
171regulation of RNA export from nucleus (GO:0046831)2.27173009
172gene silencing by RNA (GO:0031047)2.25929653
173protein localization to kinetochore (GO:0034501)2.24718488
174negative regulation of telomerase activity (GO:0051974)2.24176241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96617889
2FOXM1_23109430_ChIP-Seq_U2OS_Human2.89903330
3E2F7_22180533_ChIP-Seq_HELA_Human2.75308590
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73728272
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.54549825
6ZNF263_19887448_ChIP-Seq_K562_Human2.54185918
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.53959864
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.52013304
9MYC_22102868_ChIP-Seq_BL_Human2.50693919
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.50207142
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49789799
12KDM2B_26808549_Chip-Seq_DND41_Human2.36856825
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.33277280
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.25645012
15ZFP281_27345836_Chip-Seq_ESCs_Mouse2.11636595
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.11368370
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10407897
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.06381703
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.02800092
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96808968
21KDM2B_26808549_Chip-Seq_K562_Human1.96402246
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93326750
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92003178
24EZH2_22144423_ChIP-Seq_EOC_Human1.91567631
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.86802992
26LXR_22292898_ChIP-Seq_THP-1_Human1.84558912
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.83811793
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.83811793
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.83811793
30TCF7_22412390_ChIP-Seq_EML_Mouse1.82664768
31RACK7_27058665_Chip-Seq_MCF-7_Human1.78587092
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.77752003
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74276602
34CREB1_26743006_Chip-Seq_LNCaP_Human1.72885620
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.72832136
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.71357517
37ATF3_27146783_Chip-Seq_COLON_Human1.70767061
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.70602677
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68420755
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67735367
41CLOCK_20551151_ChIP-Seq_293T_Human1.66171540
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64592470
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61418961
44CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.59523210
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58878765
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57692404
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57692404
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56359588
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.56119872
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.54386718
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.52690479
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52385691
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51418594
54* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50538768
55VDR_21846776_ChIP-Seq_THP-1_Human1.49720743
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.49677173
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.46056372
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42024985
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41669849
60NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.40487188
61SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.40194752
62* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39312710
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38510070
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38363482
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37173548
66* P68_20966046_ChIP-Seq_HELA_Human1.37076847
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36746836
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35972415
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35795932
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.35634703
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.35454894
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.35277603
73TET1_21490601_ChIP-Seq_MESCs_Mouse1.34966362
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34017275
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.33063215
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.32315545
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.32065096
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30828804
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.30685474
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29990081
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29831450
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29793592
83MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.29196731
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27955704
85POU5F1_16518401_ChIP-PET_MESCs_Mouse1.27181739
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26831463
87TP53_22127205_ChIP-Seq_IMR90_Human1.26027902
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25705508
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.25319424
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23471042
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23383168
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22562099
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21182561
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.20839973
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20717851
96GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.20415090
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18596268
98MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17895533
99SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17509183
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17025627
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16797126
102STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.16165970
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14457311
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14204722
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13845031
106EED_16625203_ChIP-ChIP_MESCs_Mouse1.13034467
107UBF1/2_26484160_Chip-Seq_HMECs_Human1.12984334
108NCOR1_26117541_ChIP-Seq_K562_Human1.11520035
109SMC4_20622854_ChIP-Seq_HELA_Human1.11114370
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10767607
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10506309
112TP53_23651856_ChIP-Seq_MEFs_Mouse1.10410264
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09452627
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09412720
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09361035
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09278043
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09270381
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08360544
119PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.07978383
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07798317
121SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07535891
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07350886
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05857250
124CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05441233
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04871026
126* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04704833
127SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04572351
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02150470
129SA1_27219007_Chip-Seq_ERYTHROID_Human1.01911281
130* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01815494
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01552742
132CTCF_27219007_Chip-Seq_Bcells_Human1.00937137
133ELF1_20517297_ChIP-Seq_JURKAT_Human1.00228883
134THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99381978
135STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99198987
136* TBX20_22328084_ChIP-Seq_HEART_Mouse0.97789804
137* TBX20_22080862_ChIP-Seq_HEART_Mouse0.97789804
138TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97267531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.87754406
2MP0010234_abnormal_vibrissa_follicle3.16094086
3MP0000751_myopathy2.99769028
4MP0005451_abnormal_body_composition2.76303271
5MP0005257_abnormal_intraocular_pressure2.71397286
6MP0005076_abnormal_cell_differentiation2.69299222
7MP0003283_abnormal_digestive_organ2.54429546
8MP0004185_abnormal_adipocyte_glucose2.51302137
9MP0010352_gastrointestinal_tract_polyps2.39344129
10MP0005423_abnormal_somatic_nervous2.36901766
11MP0004084_abnormal_cardiac_muscle2.31718973
12MP0005623_abnormal_meninges_morphology2.30343208
13MP0004270_analgesia2.20977544
14MP0004233_abnormal_muscle_weight2.11232548
15MP0000747_muscle_weakness2.03860911
16MP0004087_abnormal_muscle_fiber2.01647050
17MP0005377_hearing/vestibular/ear_phenot1.96477116
18MP0003878_abnormal_ear_physiology1.96477116
19MP0002837_dystrophic_cardiac_calcinosis1.96070407
20MP0003329_amyloid_beta_deposits1.95820390
21MP0002269_muscular_atrophy1.93523516
22MP0003566_abnormal_cell_adhesion1.93351799
23MP0001849_ear_inflammation1.93102205
24MP0003646_muscle_fatigue1.84803156
25MP0004510_myositis1.82405240
26MP0002653_abnormal_ependyma_morphology1.80173587
27MP0003123_paternal_imprinting1.77401885
28MP0004130_abnormal_muscle_cell1.75997202
29MP0005409_darkened_coat_color1.75576574
30MP0008438_abnormal_cutaneous_collagen1.75320562
31MP0004145_abnormal_muscle_electrophysio1.75275161
32MP0002822_catalepsy1.73867896
33MP0000733_abnormal_muscle_development1.71911643
34MP0008961_abnormal_basal_metabolism1.71022952
35MP0004858_abnormal_nervous_system1.67884135
36MP0004859_abnormal_synaptic_plasticity1.67746657
37MP0003879_abnormal_hair_cell1.66019037
38MP0005670_abnormal_white_adipose1.64074510
39MP0001730_embryonic_growth_arrest1.62986268
40MP0004197_abnormal_fetal_growth/weight/1.58311882
41MP0005666_abnormal_adipose_tissue1.58082234
42MP0004036_abnormal_muscle_relaxation1.55406774
43* MP0003635_abnormal_synaptic_transmissio1.54515880
44MP0003119_abnormal_digestive_system1.52686314
45MP0010307_abnormal_tumor_latency1.51615154
46MP0000013_abnormal_adipose_tissue1.50983823
47MP0000750_abnormal_muscle_regeneration1.50867090
48MP0000537_abnormal_urethra_morphology1.50624249
49MP0002084_abnormal_developmental_patter1.48684860
50MP0010630_abnormal_cardiac_muscle1.48091977
51MP0000003_abnormal_adipose_tissue1.45991737
52MP0000759_abnormal_skeletal_muscle1.40689673
53MP0000749_muscle_degeneration1.39547075
54MP0002332_abnormal_exercise_endurance1.38706283
55MP0002877_abnormal_melanocyte_morpholog1.38704477
56MP0005167_abnormal_blood-brain_barrier1.34623653
57MP0005330_cardiomyopathy1.33778038
58MP0002106_abnormal_muscle_physiology1.33611493
59MP0002085_abnormal_embryonic_tissue1.32322289
60MP0003111_abnormal_nucleus_morphology1.31930820
61MP0005375_adipose_tissue_phenotype1.31711616
62MP0000678_abnormal_parathyroid_gland1.31280532
63MP0001672_abnormal_embryogenesis/_devel1.31133642
64MP0005380_embryogenesis_phenotype1.31133642
65MP0000579_abnormal_nail_morphology1.30591504
66MP0000350_abnormal_cell_proliferation1.28259217
67MP0002086_abnormal_extraembryonic_tissu1.26583659
68MP0003984_embryonic_growth_retardation1.26417027
69* MP0002063_abnormal_learning/memory/cond1.26411079
70MP0002088_abnormal_embryonic_growth/wei1.25726076
71MP0002249_abnormal_larynx_morphology1.23522426
72MP0009053_abnormal_anal_canal1.23072322
73MP0001697_abnormal_embryo_size1.22824253
74MP0001348_abnormal_lacrimal_gland1.17335071
75MP0002909_abnormal_adrenal_gland1.14553106
76MP0002234_abnormal_pharynx_morphology1.14128310
77MP0002080_prenatal_lethality1.13681553
78MP0004272_abnormal_basement_membrane1.12004477
79MP0009780_abnormal_chondrocyte_physiolo1.10448054
80MP0004957_abnormal_blastocyst_morpholog1.10243972
81MP0008775_abnormal_heart_ventricle1.10185710
82MP0003634_abnormal_glial_cell1.09312909
83MP0003942_abnormal_urinary_system1.09019528
84MP0009672_abnormal_birth_weight1.08701313
85MP0000778_abnormal_nervous_system1.07589770
86MP0008569_lethality_at_weaning1.06219145
87MP0000534_abnormal_ureter_morphology1.03770275
88MP0005369_muscle_phenotype1.03741241
89MP0001299_abnormal_eye_distance/1.03520041
90MP0004811_abnormal_neuron_physiology1.03491367
91MP0009278_abnormal_bone_marrow1.01447954
92MP0000266_abnormal_heart_morphology1.00778440
93MP0002089_abnormal_postnatal_growth/wei1.00125354
94MP0003045_fibrosis1.00021192
95MP0002734_abnormal_mechanical_nocicepti0.98411831
96MP0003300_gastrointestinal_ulcer0.98307293
97MP0010030_abnormal_orbit_morphology0.97941749
98MP0001346_abnormal_lacrimal_gland0.97661326
99MP0003385_abnormal_body_wall0.97544963
100MP0000428_abnormal_craniofacial_morphol0.96725767
101MP0002064_seizures0.96428868
102MP0004215_abnormal_myocardial_fiber0.96349303
103MP0000955_abnormal_spinal_cord0.95128198
104MP0003880_abnormal_central_pattern0.94794038
105MP0002925_abnormal_cardiovascular_devel0.92856360
106MP0005187_abnormal_penis_morphology0.91608719
107MP0000762_abnormal_tongue_morphology0.90339026
108MP0004885_abnormal_endolymph0.89776761
109MP0009703_decreased_birth_body0.89597491
110MP0005620_abnormal_muscle_contractility0.89345920
111MP0003279_aneurysm0.89164168
112MP0003221_abnormal_cardiomyocyte_apopto0.88970772
113MP0003567_abnormal_fetal_cardiomyocyte0.88207502
114MP0008770_decreased_survivor_rate0.87732881
115MP0005058_abnormal_lysosome_morphology0.87007689
116MP0003137_abnormal_impulse_conducting0.86886770
117MP0003115_abnormal_respiratory_system0.86428475
118MP0002108_abnormal_muscle_morphology0.86198929
119MP0009840_abnormal_foam_cell0.85845225
120MP0008260_abnormal_autophagy0.84591059
121MP0002896_abnormal_bone_mineralization0.84486402
122MP0003091_abnormal_cell_migration0.83429372
123MP0006138_congestive_heart_failure0.81850081
124MP0003935_abnormal_craniofacial_develop0.80269138
125MP0008874_decreased_physiological_sensi0.79203946
126MP0005023_abnormal_wound_healing0.78852919
127MP0004133_heterotaxia0.78676843
128MP0002184_abnormal_innervation0.78337020
129MP0003941_abnormal_skin_development0.77349065
130MP0002882_abnormal_neuron_morphology0.76516330
131MP0002152_abnormal_brain_morphology0.76237855
132MP0005385_cardiovascular_system_phenoty0.76230603
133MP0001544_abnormal_cardiovascular_syste0.76230603
134MP0003077_abnormal_cell_cycle0.76143565
135MP0003890_abnormal_embryonic-extraembry0.75880489
136MP0001958_emphysema0.75070519
137MP0003861_abnormal_nervous_system0.74539121
138MP0002972_abnormal_cardiac_muscle0.72253099
139MP0009250_abnormal_appendicular_skeleto0.71690490
140MP0003453_abnormal_keratinocyte_physiol0.71548304
141MP0010368_abnormal_lymphatic_system0.71016697
142MP0008877_abnormal_DNA_methylation0.70993009
143* MP0002066_abnormal_motor_capabilities/c0.70576101
144MP0001502_abnormal_circadian_rhythm0.67844381
145MP0001661_extended_life_span0.65231734
146MP0000767_abnormal_smooth_muscle0.64913474

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)4.16785569
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.15161081
3Nemaline bodies (HP:0003798)3.94579038
4Abnormality of the lower motor neuron (HP:0002366)3.57498066
5Difficulty running (HP:0009046)3.46676328
6Centrally nucleated skeletal muscle fibers (HP:0003687)3.38413031
7Difficulty climbing stairs (HP:0003551)3.35662190
8Hyporeflexia of lower limbs (HP:0002600)3.25855731
9Cerebral aneurysm (HP:0004944)3.16052355
10Ependymoma (HP:0002888)3.14349975
11Distal upper limb amyotrophy (HP:0007149)3.05727074
12Upper limb amyotrophy (HP:0009129)3.05727074
13Exercise-induced muscle cramps (HP:0003710)3.05136473
14Distal lower limb muscle weakness (HP:0009053)3.04805798
15Hyperacusis (HP:0010780)3.01613038
16Increased connective tissue (HP:0009025)2.97534952
17Astrocytoma (HP:0009592)2.88234571
18Abnormality of the astrocytes (HP:0100707)2.88234571
19Exercise-induced myalgia (HP:0003738)2.82641774
20Sudden death (HP:0001699)2.78190261
21Spinal rigidity (HP:0003306)2.77670975
22Hand muscle atrophy (HP:0009130)2.77443344
23Right ventricular cardiomyopathy (HP:0011663)2.75326767
24Premature rupture of membranes (HP:0001788)2.69252863
25Obstructive sleep apnea (HP:0002870)2.58730102
26Achilles tendon contracture (HP:0001771)2.56847780
27Shallow orbits (HP:0000586)2.51295134
28Ventricular tachycardia (HP:0004756)2.50714074
29Foot dorsiflexor weakness (HP:0009027)2.50247135
30Bundle branch block (HP:0011710)2.48807818
31Muscle fiber splitting (HP:0003555)2.47983111
32Back pain (HP:0003418)2.46910813
33EMG: neuropathic changes (HP:0003445)2.43829326
34Insomnia (HP:0100785)2.43399652
35Supranuclear gaze palsy (HP:0000605)2.40098110
36Abnormality of the foot musculature (HP:0001436)2.36117693
37Cerebral inclusion bodies (HP:0100314)2.35833300
38Calcaneovalgus deformity (HP:0001848)2.35206518
39Abnormality of the Achilles tendon (HP:0005109)2.33157621
40Dysmetric saccades (HP:0000641)2.33115662
41Resting tremor (HP:0002322)2.27117246
42Abnormality of the calf musculature (HP:0001430)2.26153344
43Myoglobinuria (HP:0002913)2.24563538
44Scapular winging (HP:0003691)2.21421031
45Type 1 muscle fiber predominance (HP:0003803)2.17964647
46Renal duplication (HP:0000075)2.17786591
47Turricephaly (HP:0000262)2.15944897
48Pointed chin (HP:0000307)2.15726030
49Myokymia (HP:0002411)2.14077174
50Elfin facies (HP:0004428)2.13495592
51Pelvic girdle muscle weakness (HP:0003749)2.12333886
52Increased variability in muscle fiber diameter (HP:0003557)2.11867758
53Neurofibrillary tangles (HP:0002185)2.10636448
54Hyperparathyroidism (HP:0000843)2.09352678
55Atrioventricular block (HP:0001678)2.08183129
56Ventricular fibrillation (HP:0001663)2.07801920
57Pseudobulbar signs (HP:0002200)2.07711984
58Broad face (HP:0000283)2.06321260
59Mitral regurgitation (HP:0001653)2.04793229
60Renovascular hypertension (HP:0100817)2.03915788
61Bowel diverticulosis (HP:0005222)2.01131840
62Lipoatrophy (HP:0100578)2.01114865
63Neck muscle weakness (HP:0000467)2.00238925
64Deformed tarsal bones (HP:0008119)1.98339403
65Distal arthrogryposis (HP:0005684)1.97578302
66Muscle stiffness (HP:0003552)1.97366817
67Ulnar bowing (HP:0003031)1.96860311
68Shoulder girdle muscle weakness (HP:0003547)1.96825613
69Selective tooth agenesis (HP:0001592)1.95785494
70Oligomenorrhea (HP:0000876)1.95450266
71Angiofibromas (HP:0010615)1.95346215
72Adenoma sebaceum (HP:0009720)1.95346215
73Protrusio acetabuli (HP:0003179)1.94362489
74Fragile skin (HP:0001030)1.93526128
75Macroorchidism (HP:0000053)1.93510958
76Myotonia (HP:0002486)1.93409747
77Ragged-red muscle fibers (HP:0003200)1.93042586
78Annular pancreas (HP:0001734)1.92727049
79Enlarged penis (HP:0000040)1.92482870
80Mildly elevated creatine phosphokinase (HP:0008180)1.91221162
81Rhabdomyolysis (HP:0003201)1.90388606
82Fibroma (HP:0010614)1.90211503
83Abnormality of skeletal muscle fiber size (HP:0012084)1.89546634
84Vertebral compression fractures (HP:0002953)1.88872192
85Heterotopia (HP:0002282)1.88651881
86Glioma (HP:0009733)1.88106734
87Ankle clonus (HP:0011448)1.87819250
88Metaphyseal cupping (HP:0003021)1.87245350
89Missing ribs (HP:0000921)1.86967968
90Round ear (HP:0100830)1.86558492
91Genu recurvatum (HP:0002816)1.86301704
92Aneurysm (HP:0002617)1.86199644
93Termporal pattern (HP:0011008)1.85163107
94Insidious onset (HP:0003587)1.85163107
95Progressive muscle weakness (HP:0003323)1.84282980
96Rib fusion (HP:0000902)1.84277086
97Abnormality of the hip-girdle musculature (HP:0001445)1.83708391
98Abnormality of the musculature of the pelvis (HP:0001469)1.83708391
99Malnutrition (HP:0004395)1.83468633
100Long palpebral fissure (HP:0000637)1.83392990
101Limb-girdle muscle atrophy (HP:0003797)1.82604750
102Overriding aorta (HP:0002623)1.82358423
103Bladder diverticulum (HP:0000015)1.81890525
104Abnormality of the calcaneus (HP:0008364)1.81818591
105Heart block (HP:0012722)1.81598136
106Biliary tract neoplasm (HP:0100574)1.81585358
107Bulbar palsy (HP:0001283)1.79404856
108Lymphangioma (HP:0100764)1.79332954
109Ankle contracture (HP:0006466)1.79047545
110Ventricular arrhythmia (HP:0004308)1.77269324
111Fibrous tissue neoplasm (HP:0012316)1.76750793
112Vertebral arch anomaly (HP:0008438)1.76009737
113Lower limb amyotrophy (HP:0007210)1.75682532
114Disproportionate tall stature (HP:0001519)1.74729686
115Rapidly progressive (HP:0003678)1.74048460
116Myopathic facies (HP:0002058)1.73854502
117Depression (HP:0000716)1.73732758
118Abnormal atrioventricular conduction (HP:0005150)1.73706876
119Frequent falls (HP:0002359)1.73209611
120Atrial fibrillation (HP:0005110)1.72722840
121EMG: myopathic abnormalities (HP:0003458)1.72367952
122Muscle hypertrophy of the lower extremities (HP:0008968)1.72105126
123Supraventricular tachycardia (HP:0004755)1.71452612
124Hypoventilation (HP:0002791)1.71095893
125Asymmetric septal hypertrophy (HP:0001670)1.70617652
126Supraventricular arrhythmia (HP:0005115)1.70044248
127Atrophic scars (HP:0001075)1.69862422
128Rimmed vacuoles (HP:0003805)1.69743878
129Hammertoe (HP:0001765)1.68515729
130Generalized muscle weakness (HP:0003324)1.68329947
131Slender build (HP:0001533)1.67976702
132Subaortic stenosis (HP:0001682)1.67924189
133Abnormality of the left ventricular outflow tract (HP:0011103)1.67924189
134Primary atrial arrhythmia (HP:0001692)1.67715745
135Flat acetabular roof (HP:0003180)1.67609862
136Spastic diplegia (HP:0001264)1.66724159
137Distal lower limb amyotrophy (HP:0008944)1.66402854
138Truncus arteriosus (HP:0001660)1.66342833
139Limb-girdle muscle weakness (HP:0003325)1.65881440
140Dilated cardiomyopathy (HP:0001644)1.65803923
141Rectal prolapse (HP:0002035)1.65535602
142Broad metatarsal (HP:0001783)1.65275506
143Neoplasm of the heart (HP:0100544)1.64848471
144Hypercortisolism (HP:0001578)1.64287626
145Ulnar deviation of the wrist (HP:0003049)1.64115389
146Mitral valve prolapse (HP:0001634)1.63745800
147Hypopigmentation of the fundus (HP:0007894)1.61393770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KSR23.81760348
2TRIB33.68102236
3MST1R3.63533820
4EEF2K3.32449742
5PKN23.13580431
6MAP3K22.92828166
7PRPF4B2.69788171
8SMG12.61995680
9CDK122.57470659
10TTN2.54431523
11MAP3K102.27360489
12PIK3CA2.17475486
13IRAK32.11036869
14NEK12.07462829
15PRKD32.00395182
16OBSCN1.99651405
17MET1.98738256
18ICK1.95930859
19TYRO31.76656228
20PDGFRA1.74093425
21MAP3K91.69321878
22LATS21.66849748
23RIPK11.66521979
24ALK1.66332858
25ARAF1.64500932
26RET1.46222205
27TAOK21.42807331
28PTK61.35856158
29NME21.32875144
30MARK11.29449045
31BMX1.29095440
32DDR21.28620500
33MAP2K21.27980197
34PAK61.23712595
35EPHA21.23502635
36SCYL21.19798714
37MARK21.16998527
38MTOR1.15537253
39PHKG11.14482034
40PHKG21.14482034
41BRAF1.13912250
42RPS6KB21.11935046
43PDK31.11329743
44PDK41.11329743
45MAP2K11.06975633
46TAOK11.06168264
47NEK21.05827642
48MAP3K111.05703039
49LMTK21.05428230
50MAP3K81.02174098
51MAPKAPK31.01898211
52MOS1.01182797
53STK380.97189818
54DMPK0.95718319
55LATS10.95707262
56MAPK120.92542398
57WNK10.90154060
58PAK40.89364448
59MAP3K10.86525506
60CDK40.86380550
61MAP3K130.85176893
62CDC70.84326584
63SGK30.83033521
64TESK10.81173643
65PDPK10.80852538
66PNCK0.79854469
67PTK20.79844230
68LIMK10.79122999
69EPHB20.78758994
70CAMK1G0.77150765
71RPS6KC10.75093930
72RPS6KL10.75093930
73TTK0.74468256
74CAMKK10.73630355
75NTRK10.73625321
76EPHA40.73384827
77NTRK20.68012660
78MAP3K60.66586911
79CDK60.64647007
80CDK11A0.63495847
81MAP3K70.63226047
82CDC42BPA0.62732190
83LRRK20.62594520
84SIK10.62315814
85CAMK1D0.62212273
86PAK20.60774920
87MAP3K30.59593414
88MAP3K40.59592723
89CAMK2G0.59479597
90CAMK40.59212554
91FGFR10.58659374
92RPS6KA60.58606691
93PAK30.58050725
94FGFR40.54986413
95RAF10.54962401
96CDK90.54588677
97CDK180.53306343
98CAMK2B0.52877823
99MAP2K30.51769378
100PDGFRB0.51641986
101MAPK110.51593300
102CAMK10.51432051
103CDK140.51218862
104UHMK10.49079964
105FER0.48889911
106NTRK30.48640648
107AURKA0.48486526
108PIM20.48343317
109PASK0.47647286
110DAPK20.47194835
111PRKCH0.46872243
112CDK50.46425921
113CSNK1E0.45882493
114AKT20.45164122
115MAPK100.44778915
116SGK4940.44464920
117SGK2230.44464920
118CHEK10.44094482
119ABL20.43897728
120CSNK1D0.43049029
121SIK20.42991724
122STK110.42714257
123PDK20.41155917
124ILK0.41117496
125NME10.41082224
126RPS6KA10.40950004
127HIPK20.40669290
128CDK20.40049042
129MAP2K40.39630874
130PRKAA10.38093311
131PRKD10.36072023
132DAPK30.35396132
133KSR10.35193946
134JAK20.35192554
135ERN10.32708486
136FLT30.31134717
137MINK10.30971226
138EPHB10.29061840
139RPS6KA20.28483057
140RPS6KA30.28260119
141DYRK1B0.27054730
142PRKD20.26089064
143CDK150.25711095
144PRKDC0.25222543

Predicted pathways (KEGG)

RankGene SetZ-score
1mTOR signaling pathway_Homo sapiens_hsa041502.13171260
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94240580
3Nitrogen metabolism_Homo sapiens_hsa009101.93624956
4Dorso-ventral axis formation_Homo sapiens_hsa043201.89296208
5Central carbon metabolism in cancer_Homo sapiens_hsa052301.81390706
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81115063
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79883985
8Thyroid cancer_Homo sapiens_hsa052161.72148971
9Bladder cancer_Homo sapiens_hsa052191.70560044
10Type II diabetes mellitus_Homo sapiens_hsa049301.61264527
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54646198
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53492193
13Chronic myeloid leukemia_Homo sapiens_hsa052201.50096823
14Dilated cardiomyopathy_Homo sapiens_hsa054141.47616433
15Glioma_Homo sapiens_hsa052141.47452054
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46384295
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42068007
18Tight junction_Homo sapiens_hsa045301.41585927
19Adherens junction_Homo sapiens_hsa045201.40217549
20Insulin signaling pathway_Homo sapiens_hsa049101.39804449
21Endometrial cancer_Homo sapiens_hsa052131.35684976
22VEGF signaling pathway_Homo sapiens_hsa043701.35378776
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.33738466
24Estrogen signaling pathway_Homo sapiens_hsa049151.33080797
25Non-small cell lung cancer_Homo sapiens_hsa052231.29279199
26Cardiac muscle contraction_Homo sapiens_hsa042601.27999908
27Hippo signaling pathway_Homo sapiens_hsa043901.27416280
28Proteoglycans in cancer_Homo sapiens_hsa052051.23919621
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23887092
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22733343
31Focal adhesion_Homo sapiens_hsa045101.19915371
32Biosynthesis of amino acids_Homo sapiens_hsa012301.19523836
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17926843
34Long-term potentiation_Homo sapiens_hsa047201.17915723
35Bile secretion_Homo sapiens_hsa049761.16222228
36Oocyte meiosis_Homo sapiens_hsa041141.15148098
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15039544
38Sulfur relay system_Homo sapiens_hsa041221.13877376
39Glucagon signaling pathway_Homo sapiens_hsa049221.13272718
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11775878
41Gap junction_Homo sapiens_hsa045401.10314458
42GnRH signaling pathway_Homo sapiens_hsa049121.10247933
43Axon guidance_Homo sapiens_hsa043601.09629957
44Insulin resistance_Homo sapiens_hsa049311.08693500
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08541677
46Cocaine addiction_Homo sapiens_hsa050301.07868067
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07633577
48Renal cell carcinoma_Homo sapiens_hsa052111.04431627
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03795708
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.02547818
51Lysine degradation_Homo sapiens_hsa003101.01830851
52AMPK signaling pathway_Homo sapiens_hsa041521.01537044
53Prion diseases_Homo sapiens_hsa050201.01356984
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01098690
55Oxytocin signaling pathway_Homo sapiens_hsa049211.01086424
56Phenylalanine metabolism_Homo sapiens_hsa003600.99900741
57Colorectal cancer_Homo sapiens_hsa052100.99817047
58HIF-1 signaling pathway_Homo sapiens_hsa040660.99618402
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97976184
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96578876
61Carbon metabolism_Homo sapiens_hsa012000.95047252
62Amphetamine addiction_Homo sapiens_hsa050310.94757334
63MicroRNAs in cancer_Homo sapiens_hsa052060.94383970
64ErbB signaling pathway_Homo sapiens_hsa040120.94171356
65Pentose phosphate pathway_Homo sapiens_hsa000300.93944353
66mRNA surveillance pathway_Homo sapiens_hsa030150.91861552
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91847223
68Dopaminergic synapse_Homo sapiens_hsa047280.90148581
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89140086
70Salivary secretion_Homo sapiens_hsa049700.86289282
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84885000
72Melanogenesis_Homo sapiens_hsa049160.84843926
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.84817754
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83690696
75Basal cell carcinoma_Homo sapiens_hsa052170.83348770
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82563360
77Gastric acid secretion_Homo sapiens_hsa049710.82483029
78Circadian entrainment_Homo sapiens_hsa047130.81608510
79Arginine biosynthesis_Homo sapiens_hsa002200.80417333
80Fatty acid biosynthesis_Homo sapiens_hsa000610.80144480
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.79687524
82* RNA transport_Homo sapiens_hsa030130.78655715
83Hedgehog signaling pathway_Homo sapiens_hsa043400.78340401
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77487523
85Notch signaling pathway_Homo sapiens_hsa043300.76624473
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75942408
87Calcium signaling pathway_Homo sapiens_hsa040200.75744544
88Acute myeloid leukemia_Homo sapiens_hsa052210.75130091
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74744331
90Arginine and proline metabolism_Homo sapiens_hsa003300.74442050
91Mineral absorption_Homo sapiens_hsa049780.73368767
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73335882
93Inositol phosphate metabolism_Homo sapiens_hsa005620.72990442
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72740909
95Insulin secretion_Homo sapiens_hsa049110.72542171
96cAMP signaling pathway_Homo sapiens_hsa040240.72176654
97Glutamatergic synapse_Homo sapiens_hsa047240.72164813
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71306017
99Small cell lung cancer_Homo sapiens_hsa052220.70829636
100Vibrio cholerae infection_Homo sapiens_hsa051100.70391854
101Prolactin signaling pathway_Homo sapiens_hsa049170.70304681
102Melanoma_Homo sapiens_hsa052180.70093577
103GABAergic synapse_Homo sapiens_hsa047270.69913686
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69346487
105Fructose and mannose metabolism_Homo sapiens_hsa000510.68637815
106Rap1 signaling pathway_Homo sapiens_hsa040150.68370988
107Galactose metabolism_Homo sapiens_hsa000520.67353807
108Morphine addiction_Homo sapiens_hsa050320.66654438
109Pancreatic cancer_Homo sapiens_hsa052120.65312536
110MAPK signaling pathway_Homo sapiens_hsa040100.64926128
111Amoebiasis_Homo sapiens_hsa051460.64791776
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64450615
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64356211
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62682005
115Synaptic vesicle cycle_Homo sapiens_hsa047210.62453007
116Choline metabolism in cancer_Homo sapiens_hsa052310.62138349
117TGF-beta signaling pathway_Homo sapiens_hsa043500.61519124
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60930092
119Endocytosis_Homo sapiens_hsa041440.60795797
120Viral carcinogenesis_Homo sapiens_hsa052030.60276410
121Olfactory transduction_Homo sapiens_hsa047400.60130823
122Long-term depression_Homo sapiens_hsa047300.59864250
123ECM-receptor interaction_Homo sapiens_hsa045120.57922709
124Viral myocarditis_Homo sapiens_hsa054160.57815756
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57453385
126FoxO signaling pathway_Homo sapiens_hsa040680.55609274
127Cholinergic synapse_Homo sapiens_hsa047250.55556132

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