FXYD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)7.54319325
2actin-mediated cell contraction (GO:0070252)6.87934590
3skeletal muscle contraction (GO:0003009)6.65017901
4creatine metabolic process (GO:0006600)6.02936304
5striated muscle contraction (GO:0006941)5.69630778
6regulation of relaxation of muscle (GO:1901077)5.66142744
7regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.31348709
8L-phenylalanine catabolic process (GO:0006559)5.20959367
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.20959367
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.12631265
11actin filament-based movement (GO:0030048)5.10982017
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.09198349
13L-phenylalanine metabolic process (GO:0006558)5.09198349
14response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.90758639
15regulation of cell communication by electrical coupling (GO:0010649)4.75352153
16lysine metabolic process (GO:0006553)4.74787985
17lysine catabolic process (GO:0006554)4.74787985
18regulation of actin filament-based movement (GO:1903115)4.64171362
19kynurenine metabolic process (GO:0070189)4.62457815
20glyoxylate metabolic process (GO:0046487)4.61241008
21alpha-linolenic acid metabolic process (GO:0036109)4.60315873
22aromatic amino acid family catabolic process (GO:0009074)4.58312433
23regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.57545061
24response to muscle activity (GO:0014850)4.55731064
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.51872018
26NADH metabolic process (GO:0006734)4.49451922
272-oxoglutarate metabolic process (GO:0006103)4.44402821
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.44071095
29regulation of triglyceride catabolic process (GO:0010896)4.34955988
30skeletal muscle fiber development (GO:0048741)4.34273210
31cardiac muscle hypertrophy (GO:0003300)4.34011847
32carnitine shuttle (GO:0006853)4.31352986
33fatty acid transmembrane transport (GO:1902001)4.29609243
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.28431791
35* muscle contraction (GO:0006936)4.25795511
36cellular ketone body metabolic process (GO:0046950)4.21832148
37aspartate family amino acid catabolic process (GO:0009068)4.21091551
38sarcomere organization (GO:0045214)4.20179259
39regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.17043777
40striated muscle hypertrophy (GO:0014897)4.14813196
41high-density lipoprotein particle remodeling (GO:0034375)4.14747950
42bile acid biosynthetic process (GO:0006699)4.14080057
43tryptophan catabolic process (GO:0006569)4.12889892
44indole-containing compound catabolic process (GO:0042436)4.12889892
45indolalkylamine catabolic process (GO:0046218)4.12889892
46fatty acid beta-oxidation (GO:0006635)4.04712263
47amino-acid betaine metabolic process (GO:0006577)4.02434782
48regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.99255286
49sulfur amino acid catabolic process (GO:0000098)3.93293136
50regulation of cholesterol esterification (GO:0010872)3.91551011
51negative regulation of fibrinolysis (GO:0051918)3.90439494
52glycogen catabolic process (GO:0005980)3.88902820
53myotube cell development (GO:0014904)3.88866826
54cardiac myofibril assembly (GO:0055003)3.85775572
55tryptophan metabolic process (GO:0006568)3.85540497
56response to inactivity (GO:0014854)3.85447297
57* muscle system process (GO:0003012)3.85241483
58short-chain fatty acid metabolic process (GO:0046459)3.84644951
59reverse cholesterol transport (GO:0043691)3.82379124
60acetyl-CoA metabolic process (GO:0006084)3.81597355
61actomyosin structure organization (GO:0031032)3.79488957
62peptidyl-glutamic acid carboxylation (GO:0017187)3.76352612
63protein carboxylation (GO:0018214)3.76352612
64regulation of fibrinolysis (GO:0051917)3.75509602
65muscle hypertrophy (GO:0014896)3.75266339
66serine family amino acid catabolic process (GO:0009071)3.74173709
67regulation of protein activation cascade (GO:2000257)3.73496761
68fatty acid oxidation (GO:0019395)3.71946396
69dicarboxylic acid biosynthetic process (GO:0043650)3.71225455
70complement activation, alternative pathway (GO:0006957)3.71171639
71tricarboxylic acid cycle (GO:0006099)3.70989341
72alpha-amino acid catabolic process (GO:1901606)3.70733888
73positive regulation of fatty acid beta-oxidation (GO:0032000)3.69715159
74lipid oxidation (GO:0034440)3.69229202
75protein-lipid complex remodeling (GO:0034368)3.68648923
76macromolecular complex remodeling (GO:0034367)3.68648923
77plasma lipoprotein particle remodeling (GO:0034369)3.68648923
78fatty acid catabolic process (GO:0009062)3.68250412
79cysteine metabolic process (GO:0006534)3.64314388
80neuronal action potential propagation (GO:0019227)3.63922724
81ketone body metabolic process (GO:1902224)3.63174146
82regulation of sequestering of triglyceride (GO:0010889)3.63128317
83glucan catabolic process (GO:0009251)3.62681051
84cardiac muscle adaptation (GO:0014887)3.62672619
85cardiac muscle hypertrophy in response to stress (GO:0014898)3.62672619
86muscle hypertrophy in response to stress (GO:0003299)3.62672619
87phospholipid homeostasis (GO:0055091)3.59926114
88carnitine metabolic process (GO:0009437)3.59061080
89positive regulation of fatty acid oxidation (GO:0046321)3.58814231
90ethanol oxidation (GO:0006069)3.58562733
91myofibril assembly (GO:0030239)3.58340374
92urea cycle (GO:0000050)3.58145177
93urea metabolic process (GO:0019627)3.58145177
94monocarboxylic acid catabolic process (GO:0072329)3.57407076
95striated muscle adaptation (GO:0014888)3.56615134
96muscle filament sliding (GO:0030049)3.54175890
97actin-myosin filament sliding (GO:0033275)3.54175890
98homocysteine metabolic process (GO:0050667)3.54022994
99plasma membrane repair (GO:0001778)3.53370208
100acylglycerol homeostasis (GO:0055090)3.52454587
101triglyceride homeostasis (GO:0070328)3.52454587
102regulation of complement activation (GO:0030449)3.50907348
103regulation of fatty acid oxidation (GO:0046320)3.49802742
104positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.49025912
105plasma lipoprotein particle clearance (GO:0034381)3.48776089
106regulation of calcium ion transmembrane transport (GO:1903169)3.48294413
107regulation of calcium ion transmembrane transporter activity (GO:1901019)3.48294413
108cellular amino acid catabolic process (GO:0009063)3.48276322
109branched-chain amino acid catabolic process (GO:0009083)3.47467249
110bile acid metabolic process (GO:0008206)3.47368206
111skeletal muscle adaptation (GO:0043501)3.47241674
112cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46646653
113regulation of striated muscle contraction (GO:0006942)3.45706435
114phospholipid efflux (GO:0033700)3.44818654
115coenzyme catabolic process (GO:0009109)3.44361527
116glucan biosynthetic process (GO:0009250)3.43640361
117glycogen biosynthetic process (GO:0005978)3.43640361
118carnitine transmembrane transport (GO:1902603)3.39169841
119cellular modified amino acid catabolic process (GO:0042219)3.37954448
120response to mercury ion (GO:0046689)3.36799854
121valine metabolic process (GO:0006573)3.36392318
122glutamate metabolic process (GO:0006536)3.35994488
123cellular polysaccharide catabolic process (GO:0044247)3.35893520
124positive regulation of lipid catabolic process (GO:0050996)3.33599587
125fructose metabolic process (GO:0006000)3.33062384
126regulation of skeletal muscle contraction (GO:0014819)3.32587236
127organic acid catabolic process (GO:0016054)3.31215840
128carboxylic acid catabolic process (GO:0046395)3.31215840
129nitrogen cycle metabolic process (GO:0071941)3.31146174
130negative regulation of calcium ion transmembrane transport (GO:1903170)3.30950348
131negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.30950348
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.30256510
133negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.29042763
134aromatic amino acid family metabolic process (GO:0009072)3.27011363
135regulation of membrane repolarization (GO:0060306)3.25520247
136muscle fiber development (GO:0048747)3.23906269
137regulation of the force of heart contraction (GO:0002026)3.22758418
138negative regulation of sterol transport (GO:0032372)3.22022672
139negative regulation of cholesterol transport (GO:0032375)3.22022672
140carnitine transport (GO:0015879)3.21075945
141amino-acid betaine transport (GO:0015838)3.21075945
142low-density lipoprotein particle remodeling (GO:0034374)3.17178512
143biotin metabolic process (GO:0006768)3.17062904
144gluconeogenesis (GO:0006094)3.16725715
145skeletal muscle tissue development (GO:0007519)3.16625455
146tyrosine metabolic process (GO:0006570)3.16233450
147cardiac muscle contraction (GO:0060048)3.16119367
148cellular glucuronidation (GO:0052695)3.15590538
149branched-chain amino acid metabolic process (GO:0009081)3.14801893
150positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.11123117
151bundle of His cell to Purkinje myocyte communication (GO:0086069)3.09679171
152negative regulation of potassium ion transmembrane transport (GO:1901380)3.09033115
153regulation of fatty acid beta-oxidation (GO:0031998)3.07671134
154oxaloacetate metabolic process (GO:0006107)3.06408911
155muscle tissue morphogenesis (GO:0060415)3.05349376
156adult heart development (GO:0007512)3.05277670
157cardiac muscle tissue morphogenesis (GO:0055008)3.05023773
158polysaccharide catabolic process (GO:0000272)2.99723287
159relaxation of muscle (GO:0090075)2.90466244
160positive regulation of synapse maturation (GO:0090129)2.89507535
161muscle adaptation (GO:0043500)2.89389540
162cell communication by electrical coupling (GO:0010644)2.84337555
163hexose biosynthetic process (GO:0019319)2.83876768
164glycogen metabolic process (GO:0005977)2.83594254
165muscle cell cellular homeostasis (GO:0046716)2.78917826
166positive regulation of myotube differentiation (GO:0010831)2.77496952
167cellular glucan metabolic process (GO:0006073)2.77045837
168glucan metabolic process (GO:0044042)2.77045837
169heart contraction (GO:0060047)2.76775609
170heart process (GO:0003015)2.76775609
171regulation of plasminogen activation (GO:0010755)2.74022836
172negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.72391288
173regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.67660288
174synaptic vesicle docking involved in exocytosis (GO:0016081)2.67039945
175neuromuscular synaptic transmission (GO:0007274)2.65959796
176positive regulation of cation channel activity (GO:2001259)2.65762618
177cell communication involved in cardiac conduction (GO:0086065)2.64825861
178cellular potassium ion homeostasis (GO:0030007)2.63323494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.15577298
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.47848863
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.21476817
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.45332590
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.04446782
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.42950611
7* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.24165858
8EZH2_22144423_ChIP-Seq_EOC_Human3.99065070
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.59667780
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.10304215
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.95330506
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.29348556
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05965523
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05398301
15CLOCK_20551151_ChIP-Seq_293T_Human1.97623357
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.94929918
17EP300_21415370_ChIP-Seq_HL-1_Mouse1.87487273
18EZH2_27294783_Chip-Seq_ESCs_Mouse1.86997894
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85440999
20TBX20_22080862_ChIP-Seq_HEART_Mouse1.81216485
21TBX20_22328084_ChIP-Seq_HEART_Mouse1.81216485
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.80958785
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77154333
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72165543
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68817930
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67169216
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.67038440
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.64782383
29* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62513117
30* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62513117
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57011345
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48692382
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.48607625
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48372382
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45533103
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41546879
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.41003896
38ZNF263_19887448_ChIP-Seq_K562_Human1.39125659
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.34273029
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33486427
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.29660078
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27541613
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25958888
44HTT_18923047_ChIP-ChIP_STHdh_Human1.25957705
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24896624
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23768311
47* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21517036
48SMC4_20622854_ChIP-Seq_HELA_Human1.20943492
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15096179
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13851136
51KDM2B_26808549_Chip-Seq_K562_Human1.11276862
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.10750221
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10638568
54SA1_27219007_Chip-Seq_Bcells_Human1.09545714
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.09353598
56GATA1_22025678_ChIP-Seq_K562_Human1.07411474
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.06376764
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03791571
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03004458
60HNF4A_19822575_ChIP-Seq_HepG2_Human1.02062918
61AR_21572438_ChIP-Seq_LNCaP_Human1.01823828
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01670538
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01581887
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00404514
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00259547
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99815126
67REST_21632747_ChIP-Seq_MESCs_Mouse0.99465792
68P68_20966046_ChIP-Seq_HELA_Human0.98032921
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97962092
70OCT4_19829295_ChIP-Seq_ESCs_Human0.96651042
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96228918
72SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94695738
73AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94275844
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94206750
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93059755
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90570849
77* LXR_22292898_ChIP-Seq_THP-1_Human0.90342809
78KDM2B_26808549_Chip-Seq_DND41_Human0.89551080
79WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88997803
80CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87223163
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85856459
82RING1B_27294783_Chip-Seq_ESCs_Mouse0.84817008
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84625304
84TP53_20018659_ChIP-ChIP_R1E_Mouse0.84078194
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83937771
86CTCF_27219007_Chip-Seq_Bcells_Human0.83236959
87TET1_21490601_ChIP-Seq_MESCs_Mouse0.83177484
88SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83168275
89TET1_21451524_ChIP-Seq_MESCs_Mouse0.82867061
90SA1_27219007_Chip-Seq_ERYTHROID_Human0.82789137
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82585766
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82363366
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.82242502
94NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82184972
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82184972
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79829176
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79562954
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77221157
99RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76641808
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76517757
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.75552199
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75372821
103BCAT_22108803_ChIP-Seq_LS180_Human0.73039289
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72882545
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72783243
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.70913971
107GATA4_21415370_ChIP-Seq_HL-1_Mouse0.70589943
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68387936
109GATA1_19941826_ChIP-Seq_K562_Human0.66300119
110SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.66183980
111DNAJC2_21179169_ChIP-ChIP_NT2_Human0.65700351
112MYC_27129775_Chip-Seq_CORNEA_Mouse0.64965386
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.64879059
114* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63984041
115EGR1_19032775_ChIP-ChIP_M12_Human0.62972247
116DROSHA_22980978_ChIP-Seq_HELA_Human0.62661660
117SMC3_22415368_ChIP-Seq_MEFs_Mouse0.62605947
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.62571890
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.62446778
120RACK7_27058665_Chip-Seq_MCF-7_Human0.61202653
121OCT4_20526341_ChIP-Seq_ESCs_Human0.60902947
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.60588073
123CSB_26484114_Chip-Seq_FIBROBLAST_Human0.60054823
124TP63_22573176_ChIP-Seq_HFKS_Human0.59675894
125* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.59626699
126GATA2_19941826_ChIP-Seq_K562_Human0.59426119
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59115463
128* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.58721858
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58361357
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.57355902
131GATA2_21666600_ChIP-Seq_HMVEC_Human0.56767142
132CBP_21632823_ChIP-Seq_H3396_Human0.56518592
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.55615443
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.55120229
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.54664566
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.54169758
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.54032753
138STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.53780909
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.53493843
140CJUN_26792858_Chip-Seq_BT549_Human0.53411217
141CEBPB_22108803_ChIP-Seq_LS180_Human0.53036281
142TAF2_19829295_ChIP-Seq_ESCs_Human0.52990599
143PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.52544878
144BP1_19119308_ChIP-ChIP_Hs578T_Human0.52522353
145SOX9_24532713_ChIP-Seq_HFSC_Mouse0.52156263
146TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.51845482
147SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.51077984
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.51050453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.34027831
2MP0002837_dystrophic_cardiac_calcinosis4.97985448
3MP0005360_urolithiasis4.62919543
4MP0005085_abnormal_gallbladder_physiolo4.31700014
5MP0005365_abnormal_bile_salt4.21779910
6MP0003646_muscle_fatigue3.90887279
7MP0000751_myopathy3.26299157
8MP0008875_abnormal_xenobiotic_pharmacok3.23888142
9MP0003806_abnormal_nucleotide_metabolis3.18350196
10MP0004084_abnormal_cardiac_muscle3.10744554
11MP0009840_abnormal_foam_cell2.74036232
12MP0004036_abnormal_muscle_relaxation2.72352326
13MP0004215_abnormal_myocardial_fiber2.66081401
14MP0010329_abnormal_lipoprotein_level2.60106821
15MP0000749_muscle_degeneration2.60064464
16MP0003252_abnormal_bile_duct2.53137731
17MP0005330_cardiomyopathy2.52363108
18MP0004130_abnormal_muscle_cell2.29827266
19MP0004270_analgesia2.23638936
20MP0005083_abnormal_biliary_tract2.23088079
21MP0005332_abnormal_amino_acid2.13945146
22MP0003195_calcinosis2.04079098
23MP0004087_abnormal_muscle_fiber1.96156898
24MP0005670_abnormal_white_adipose1.83339405
25MP0004859_abnormal_synaptic_plasticity1.82901380
26* MP0002972_abnormal_cardiac_muscle1.81960014
27MP0003137_abnormal_impulse_conducting1.78163733
28MP0005620_abnormal_muscle_contractility1.77473902
29MP0009780_abnormal_chondrocyte_physiolo1.71844453
30MP0002269_muscular_atrophy1.71251393
31MP0002118_abnormal_lipid_homeostasis1.70828520
32MP0003879_abnormal_hair_cell1.66253422
33MP0008775_abnormal_heart_ventricle1.65985180
34MP0006036_abnormal_mitochondrial_physio1.62844953
35* MP0005385_cardiovascular_system_phenoty1.60379839
36* MP0001544_abnormal_cardiovascular_syste1.60379839
37MP0006138_congestive_heart_failure1.59510287
38MP0003191_abnormal_cellular_cholesterol1.58553041
39MP0000750_abnormal_muscle_regeneration1.58442828
40MP0001666_abnormal_nutrient_absorption1.57511217
41MP0005319_abnormal_enzyme/_coenzyme1.55907559
42MP0010630_abnormal_cardiac_muscle1.53657529
43MP0002106_abnormal_muscle_physiology1.47309281
44MP0005666_abnormal_adipose_tissue1.45650089
45MP0000609_abnormal_liver_physiology1.44027430
46MP0000747_muscle_weakness1.38377385
47MP0003705_abnormal_hypodermis_morpholog1.37401707
48MP0010368_abnormal_lymphatic_system1.37378251
49MP0000733_abnormal_muscle_development1.36072657
50MP0004145_abnormal_muscle_electrophysio1.29938139
51MP0005423_abnormal_somatic_nervous1.28532400
52MP0005584_abnormal_enzyme/coenzyme_acti1.26988101
53MP0005451_abnormal_body_composition1.26069908
54MP0004085_abnormal_heartbeat1.24962320
55MP0005369_muscle_phenotype1.24119977
56MP0008569_lethality_at_weaning1.23952388
57MP0003011_delayed_dark_adaptation1.20119189
58MP0000759_abnormal_skeletal_muscle1.19860155
59MP0004484_altered_response_of1.12845643
60MP0000013_abnormal_adipose_tissue1.11446402
61MP0005503_abnormal_tendon_morphology1.09765294
62MP0004019_abnormal_vitamin_homeostasis1.08035571
63MP0003635_abnormal_synaptic_transmissio1.06754332
64MP0002127_abnormal_cardiovascular_syste1.05056167
65MP0002064_seizures1.04867850
66MP0002971_abnormal_brown_adipose1.04722549
67MP0003279_aneurysm1.01976260
68MP0003221_abnormal_cardiomyocyte_apopto0.99944641
69MP0002332_abnormal_exercise_endurance0.97495881
70MP0003186_abnormal_redox_activity0.96604685
71MP0003656_abnormal_erythrocyte_physiolo0.93464922
72MP0002272_abnormal_nervous_system0.91416657
73MP0003828_pulmonary_edema0.90983812
74MP0001764_abnormal_homeostasis0.90652278
75MP0002734_abnormal_mechanical_nocicepti0.89943409
76MP0009643_abnormal_urine_homeostasis0.88496217
77MP0003690_abnormal_glial_cell0.88468891
78MP0003868_abnormal_feces_composition0.88347446
79MP0004233_abnormal_muscle_weight0.88240807
80MP0005266_abnormal_metabolism0.87605527
81MP0009745_abnormal_behavioral_response0.87602981
82MP0005165_increased_susceptibility_to0.86983042
83MP0006035_abnormal_mitochondrial_morpho0.86903449
84MP0004185_abnormal_adipocyte_glucose0.86581445
85MP0001486_abnormal_startle_reflex0.85988756
86MP0002078_abnormal_glucose_homeostasis0.85298155
87MP0003880_abnormal_central_pattern0.84680775
88MP0002822_catalepsy0.82356555
89MP0000230_abnormal_systemic_arterial0.82170036
90MP0005375_adipose_tissue_phenotype0.82098180
91MP0009697_abnormal_copulation0.81494601
92MP0009384_cardiac_valve_regurgitation0.80828165
93MP0002138_abnormal_hepatobiliary_system0.79581296
94MP0002063_abnormal_learning/memory/cond0.79334960
95MP0005535_abnormal_body_temperature0.78615997
96MP0003329_amyloid_beta_deposits0.78253151
97MP0000343_altered_response_to0.76948288
98MP0001501_abnormal_sleep_pattern0.75428287
99MP0003950_abnormal_plasma_membrane0.75051424
100MP0002108_abnormal_muscle_morphology0.75034900
101MP0005334_abnormal_fat_pad0.74427855
102MP0005647_abnormal_sex_gland0.73659138
103MP0000604_amyloidosis0.73569296
104MP0001661_extended_life_span0.73234955
105MP0002876_abnormal_thyroid_physiology0.71463188
106MP0000003_abnormal_adipose_tissue0.70491771
107MP0003075_altered_response_to0.69995920
108MP0008438_abnormal_cutaneous_collagen0.69882415
109MP0004510_myositis0.69486341
110MP0005166_decreased_susceptibility_to0.67545264
111MP0002638_abnormal_pupillary_reflex0.67326044
112MP0008874_decreased_physiological_sensi0.65993329
113MP0001440_abnormal_grooming_behavior0.64814178
114MP0000598_abnormal_liver_morphology0.64778525
115MP0005376_homeostasis/metabolism_phenot0.64716606
116MP0002128_abnormal_blood_circulation0.62369043
117MP0009642_abnormal_blood_homeostasis0.61530238
118MP0009764_decreased_sensitivity_to0.61508015
119MP0002066_abnormal_motor_capabilities/c0.60959590
120MP0002254_reproductive_system_inflammat0.60375877
121MP0009763_increased_sensitivity_to0.60011256
122MP0002933_joint_inflammation0.59306919
123MP0003633_abnormal_nervous_system0.58607945
124MP0000920_abnormal_myelination0.58518773
125MP0002249_abnormal_larynx_morphology0.58376353
126MP0001502_abnormal_circadian_rhythm0.57236617
127MP0002909_abnormal_adrenal_gland0.55321440
128MP0005167_abnormal_blood-brain_barrier0.55215480
129MP0002572_abnormal_emotion/affect_behav0.54591571
130MP0001958_emphysema0.53463325
131MP0005595_abnormal_vascular_smooth0.53303023
132* MP0000266_abnormal_heart_morphology0.53044131
133MP0004043_abnormal_pH_regulation0.52784558
134MP0009115_abnormal_fat_cell0.52736731
135MP0005636_abnormal_mineral_homeostasis0.52146378
136MP0005275_abnormal_skin_tensile0.51066613
137MP0009046_muscle_twitch0.50006065

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.97745937
2Nemaline bodies (HP:0003798)8.96196990
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.68566091
4Distal arthrogryposis (HP:0005684)4.98035380
5Sudden death (HP:0001699)4.92922779
6Round ear (HP:0100830)4.86390661
7Myopathic facies (HP:0002058)4.85069687
8Deep venous thrombosis (HP:0002625)4.68631924
9Exercise-induced myalgia (HP:0003738)4.59370618
10Intrahepatic cholestasis (HP:0001406)4.40520576
11Ulnar deviation of the wrist (HP:0003049)4.37830497
12Xanthomatosis (HP:0000991)4.36268934
13Abnormality of aromatic amino acid family metabolism (HP:0004338)4.33749450
14Exercise-induced muscle cramps (HP:0003710)4.26994202
15Centrally nucleated skeletal muscle fibers (HP:0003687)4.22197145
16Ventricular tachycardia (HP:0004756)4.20580264
17Calf muscle hypertrophy (HP:0008981)4.19505160
18Myoglobinuria (HP:0002913)4.17153181
19Ketosis (HP:0001946)4.16208314
20Hypoglycemic coma (HP:0001325)4.11507318
21Hyperlipoproteinemia (HP:0010980)4.10147031
22Abnormality of skeletal muscle fiber size (HP:0012084)4.09020434
23Neck muscle weakness (HP:0000467)3.98428761
24Distal lower limb muscle weakness (HP:0009053)3.97773860
25Hyperammonemia (HP:0001987)3.95363874
26Muscle hypertrophy of the lower extremities (HP:0008968)3.89627315
27Hyperglycinuria (HP:0003108)3.84059628
28Prolonged partial thromboplastin time (HP:0003645)3.82572270
29Hypoalphalipoproteinemia (HP:0003233)3.80969486
30Ketoacidosis (HP:0001993)3.78543222
31Abnormality of monocarboxylic acid metabolism (HP:0010996)3.69448877
32Muscle fiber splitting (HP:0003555)3.68859691
33Abnormality of fatty-acid metabolism (HP:0004359)3.64931642
34Increased variability in muscle fiber diameter (HP:0003557)3.55596536
35Right ventricular cardiomyopathy (HP:0011663)3.55567717
36Hyporeflexia of lower limbs (HP:0002600)3.55159520
37Abnormality of serine family amino acid metabolism (HP:0010894)3.54570054
38Abnormality of glycine metabolism (HP:0010895)3.54570054
39Hypobetalipoproteinemia (HP:0003563)3.52501770
40Atrial fibrillation (HP:0005110)3.47531292
41Rimmed vacuoles (HP:0003805)3.47082431
42Hypolipoproteinemia (HP:0010981)3.47065037
43Lipoatrophy (HP:0100578)3.42997273
44Hyperglycinemia (HP:0002154)3.41122868
45Abnormality of the calf musculature (HP:0001430)3.35972404
46Complement deficiency (HP:0004431)3.30048492
47Calcaneovalgus deformity (HP:0001848)3.26491972
48EMG: neuropathic changes (HP:0003445)3.20430465
49Primary atrial arrhythmia (HP:0001692)3.19552140
50Rhabdomyolysis (HP:0003201)3.19515994
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.15273604
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.14257344
53Abnormality of the left ventricular outflow tract (HP:0011103)3.13646320
54Subaortic stenosis (HP:0001682)3.13646320
55Abnormality of dicarboxylic acid metabolism (HP:0010995)3.10979958
56Dicarboxylic aciduria (HP:0003215)3.10979958
57Palpitations (HP:0001962)3.10832427
58Asymmetric septal hypertrophy (HP:0001670)3.09098679
59Supraventricular tachycardia (HP:0004755)3.06518003
60Cerebral edema (HP:0002181)3.05223737
61Frequent falls (HP:0002359)3.04283263
62Atrioventricular block (HP:0001678)3.03552709
63Supraventricular arrhythmia (HP:0005115)2.99863723
64Dilated cardiomyopathy (HP:0001644)2.97792125
65Areflexia of lower limbs (HP:0002522)2.97551651
66Syncope (HP:0001279)2.92658763
67Absent phalangeal crease (HP:0006109)2.92498803
68Deformed tarsal bones (HP:0008119)2.85155740
69Heart block (HP:0012722)2.84068672
70EMG: myopathic abnormalities (HP:0003458)2.83606410
71Increased connective tissue (HP:0009025)2.81472737
72Epidermoid cyst (HP:0200040)2.78688532
73Mildly elevated creatine phosphokinase (HP:0008180)2.70127660
74Abnormal atrioventricular conduction (HP:0005150)2.67358640
75Bundle branch block (HP:0011710)2.66789047
76Joint hemorrhage (HP:0005261)2.66024745
77Ventricular arrhythmia (HP:0004308)2.65814556
78Malignant hyperthermia (HP:0002047)2.64985292
79Abnormality of methionine metabolism (HP:0010901)2.59991540
80Cholelithiasis (HP:0001081)2.59031935
81Metabolic acidosis (HP:0001942)2.58507904
82Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56745994
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.55379284
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.53205995
85Bulbar palsy (HP:0001283)2.53102777
86Hepatic necrosis (HP:0002605)2.51163855
87Lethargy (HP:0001254)2.50870216
88Generalized muscle weakness (HP:0003324)2.50725171
89Abnormality of the common coagulation pathway (HP:0010990)2.49307382
90Distal lower limb amyotrophy (HP:0008944)2.48659794
91Abnormal gallbladder morphology (HP:0012437)2.47973684
92Abnormality of the foot musculature (HP:0001436)2.47819904
93Prolonged QT interval (HP:0001657)2.47384015
94Hyperinsulinemic hypoglycemia (HP:0000825)2.45960506
95Hypercholesterolemia (HP:0003124)2.41823698
96Skin nodule (HP:0200036)2.39811442
97Difficulty running (HP:0009046)2.39301161
98Fetal akinesia sequence (HP:0001989)2.37690043
99Myotonia (HP:0002486)2.37012928
100Gowers sign (HP:0003391)2.36290159
101Acute encephalopathy (HP:0006846)2.34854824
102Foot dorsiflexor weakness (HP:0009027)2.34337757
103Abnormality of serum amino acid levels (HP:0003112)2.31974077
104Muscle stiffness (HP:0003552)2.31938943
105Abnormal finger flexion creases (HP:0006143)2.31571950
106Abnormality of the intrinsic pathway (HP:0010989)2.30946543
107Hyperbilirubinemia (HP:0002904)2.29278611
108Generalized aminoaciduria (HP:0002909)2.26341837
109Late onset (HP:0003584)2.26218845
110Abnormality of complement system (HP:0005339)2.25405770
111Scapular winging (HP:0003691)2.23717623
112Fat malabsorption (HP:0002630)2.21928182
113Weak cry (HP:0001612)2.18794794
114Delayed CNS myelination (HP:0002188)2.16123302
115Increased muscle lipid content (HP:0009058)2.14406380
116Hip contracture (HP:0003273)2.13151874
117Type 1 muscle fiber predominance (HP:0003803)2.13142815
118Lower limb amyotrophy (HP:0007210)2.12935812
119Ragged-red muscle fibers (HP:0003200)2.12811240
120Vomiting (HP:0002013)2.09855731
121Difficulty climbing stairs (HP:0003551)2.06225806
122Hypoglycemic seizures (HP:0002173)2.06145238
123Gout (HP:0001997)2.04367502
124Slender build (HP:0001533)2.02900802
125Ventricular fibrillation (HP:0001663)2.02500517
126Hyperglycemia (HP:0003074)2.01803948
127Abnormal mitochondria in muscle tissue (HP:0008316)1.99487045
128Spinal rigidity (HP:0003306)1.98608839
129Waddling gait (HP:0002515)1.97326356
130Limb-girdle muscle atrophy (HP:0003797)1.95245638
131Myocardial infarction (HP:0001658)1.92260312
132Abnormality of purine metabolism (HP:0004352)1.91986255
133Acute necrotizing encephalopathy (HP:0006965)1.91345984
134Vascular calcification (HP:0004934)1.85950895
135Hepatocellular necrosis (HP:0001404)1.84940938
136Fatigable weakness (HP:0003473)1.84294372
137Abnormality of the neuromuscular junction (HP:0003398)1.84294372
138Proximal amyotrophy (HP:0007126)1.83490743
139Abnormal gallbladder physiology (HP:0012438)1.81582599
140Cholecystitis (HP:0001082)1.81582599
141Lactic acidosis (HP:0003128)1.81200506
142Hyperkalemia (HP:0002153)1.80602798
143Systemic lupus erythematosus (HP:0002725)1.78886649
144Respiratory insufficiency due to muscle weakness (HP:0002747)1.78586595
145Abnormality of the calcaneus (HP:0008364)1.73403072
146Progressive muscle weakness (HP:0003323)1.72802157
147Limited hip movement (HP:0008800)1.71321009
148Muscular dystrophy (HP:0003560)1.67821859
149Myokymia (HP:0002411)1.65976947
150Abnormal EKG (HP:0003115)1.64871191
151Obstructive sleep apnea (HP:0002870)1.63502062
152Ankle clonus (HP:0011448)1.62775163
153Abnormality of the shoulder girdle musculature (HP:0001435)1.60223559
154Nonprogressive disorder (HP:0003680)1.55899205
155Oligomenorrhea (HP:0000876)1.54062363
156Exercise intolerance (HP:0003546)1.53217278
157Focal motor seizures (HP:0011153)1.49951336
158Facial diplegia (HP:0001349)1.49501980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.05009823
2TTN4.40752152
3PHKG23.68773102
4PHKG13.68773102
5OBSCN3.58169811
6LMTK23.44699740
7MYLK3.04822434
8TRIB33.04235145
9SIK12.71954806
10PKN22.62653038
11PDK42.52879644
12PDK32.52879644
13PINK12.21273640
14MARK11.96063912
15ERN11.95694277
16PIK3CA1.92274840
17INSRR1.91026838
18DMPK1.88515009
19MUSK1.88290973
20FGFR41.85258437
21TIE11.82011170
22PAK61.47725082
23PDK21.46328363
24MAPK121.38465133
25NEK11.36763997
26MAP3K71.30455322
27PRPF4B1.29268506
28NTRK31.18253415
29PRKAA21.15125893
30MAP2K41.12488620
31FLT31.11215536
32PIK3CG1.10672260
33PAK31.09706207
34STK38L1.06355360
35ARAF1.02548497
36MAP2K31.02520331
37LIMK11.01649247
38STK241.01314084
39PRKD11.01112727
40UHMK10.93078970
41PRKAA10.89959557
42RIPK10.89366425
43EEF2K0.88098566
44EPHB10.87665250
45PTK60.87471625
46MAP3K30.86969390
47ROCK10.86622450
48CAMK2B0.86450840
49CAMK2D0.86213312
50KSR20.83699168
51NEK90.81929156
52MAPK110.81162251
53DYRK1B0.79140856
54LATS10.78271085
55GRK50.74813468
56CAMK1D0.72242054
57MAP3K130.72235893
58GRK70.71892898
59PKN10.71227683
60CAMK2G0.70952485
61KDR0.70521567
62PRKD30.69951618
63MOS0.69017499
64MARK20.68877239
65CAMK40.68085214
66TGFBR20.67647068
67CDC42BPA0.67124242
68SGK30.66955149
69ERBB40.66817559
70PDGFRA0.66803968
71MAP3K50.66264058
72NME10.64880435
73MAP3K110.58649450
74DAPK30.58510216
75ILK0.57205245
76* PRKACG0.56878663
77SGK20.54772429
78SGK10.53648733
79CAMKK10.53509417
80MAP2K60.52773264
81PTK2B0.52492811
82STK380.52415989
83CCNB10.52010164
84MAPKAPK30.51075189
85CDK50.50626355
86JAK20.50272037
87MST1R0.50257335
88JAK10.50007528
89MAPK40.49683005
90PDPK10.49572305
91RPS6KA30.49455076
92EPHA30.49285797
93ICK0.49008799
94ABL20.48677609
95CAMK2A0.48645130
96PRKACB0.48281618
97MAPK70.48277242
98MAPK100.47621099
99CAMK1G0.46736225
100MAP3K90.45860838
101NTRK20.44803045
102MAP3K10.44093496
103LATS20.42540759
104MAPK130.42471774
105ZAK0.42353793
106* PRKACA0.41846753
107DAPK20.41198730
108EPHB20.39512793
109STK110.39236088
110WNK40.38235000
111TNK20.38229416
112PRKCH0.37997196
113SGK4940.37117866
114SGK2230.37117866
115TYK20.37006099
116CAMK10.36510604
117TRPM70.36307224
118MAP3K60.35481328
119TBK10.34986766
120EPHA40.34306023
121PRKCE0.34037221
122ROCK20.33514264
123MAP2K10.32245534
124MAP2K20.31510759
125RPS6KL10.31410735
126RPS6KC10.31410735
127TAOK30.31098199
128PDK10.30226191
129TESK10.29970244
130RET0.29715554
131AKT20.29024954
132TAOK20.28346162
133PRKG10.27493463
134MINK10.27413452
135FGFR20.27278874
136PRKG20.27039969

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.72965735
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.37214277
3Fatty acid degradation_Homo sapiens_hsa000713.18075011
4Nitrogen metabolism_Homo sapiens_hsa009103.02133126
5Propanoate metabolism_Homo sapiens_hsa006402.90526985
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.84512928
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.83268902
8Arginine biosynthesis_Homo sapiens_hsa002202.69861792
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63254135
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.60341220
11Fatty acid metabolism_Homo sapiens_hsa012122.48445465
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47780320
13Tryptophan metabolism_Homo sapiens_hsa003802.38094828
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.36763756
15Butanoate metabolism_Homo sapiens_hsa006502.22248137
16PPAR signaling pathway_Homo sapiens_hsa033202.15433117
17Complement and coagulation cascades_Homo sapiens_hsa046102.00097104
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93140541
19Peroxisome_Homo sapiens_hsa041461.89977219
20Carbon metabolism_Homo sapiens_hsa012001.84573444
21Pyruvate metabolism_Homo sapiens_hsa006201.81278866
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70537522
23beta-Alanine metabolism_Homo sapiens_hsa004101.64521345
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.63387097
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62493881
26Fatty acid elongation_Homo sapiens_hsa000621.61298287
27Starch and sucrose metabolism_Homo sapiens_hsa005001.55867117
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50616585
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45422959
30Chemical carcinogenesis_Homo sapiens_hsa052041.44049087
31Oxytocin signaling pathway_Homo sapiens_hsa049211.41711426
32Phenylalanine metabolism_Homo sapiens_hsa003601.41516626
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41204124
34Biosynthesis of amino acids_Homo sapiens_hsa012301.39010132
35Long-term potentiation_Homo sapiens_hsa047201.34327868
36Caffeine metabolism_Homo sapiens_hsa002321.32752906
37Cardiac muscle contraction_Homo sapiens_hsa042601.32317182
38Bile secretion_Homo sapiens_hsa049761.28331999
39Histidine metabolism_Homo sapiens_hsa003401.21961272
40Tyrosine metabolism_Homo sapiens_hsa003501.20421267
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.19890554
42Gastric acid secretion_Homo sapiens_hsa049711.18840672
43Circadian entrainment_Homo sapiens_hsa047131.17641555
44Retinol metabolism_Homo sapiens_hsa008301.14157219
45Insulin secretion_Homo sapiens_hsa049111.12284417
46Fatty acid biosynthesis_Homo sapiens_hsa000611.11909680
47Arginine and proline metabolism_Homo sapiens_hsa003301.09306122
48Staphylococcus aureus infection_Homo sapiens_hsa051501.08959193
49Sulfur metabolism_Homo sapiens_hsa009201.08549804
50Dilated cardiomyopathy_Homo sapiens_hsa054141.08204845
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.07998198
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07245929
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06439037
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05875296
55Renin secretion_Homo sapiens_hsa049241.04374468
56Amphetamine addiction_Homo sapiens_hsa050311.03247726
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03203066
58Fat digestion and absorption_Homo sapiens_hsa049751.01691782
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.98307743
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97298422
61GABAergic synapse_Homo sapiens_hsa047270.96022466
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94730694
63Selenocompound metabolism_Homo sapiens_hsa004500.91601748
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90295140
65Oxidative phosphorylation_Homo sapiens_hsa001900.90203610
66Parkinsons disease_Homo sapiens_hsa050120.88676586
67Lysine degradation_Homo sapiens_hsa003100.88375597
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84726536
69ABC transporters_Homo sapiens_hsa020100.84555818
70Synaptic vesicle cycle_Homo sapiens_hsa047210.76426700
71GnRH signaling pathway_Homo sapiens_hsa049120.75254529
72Sulfur relay system_Homo sapiens_hsa041220.74913132
73Glutamatergic synapse_Homo sapiens_hsa047240.71524804
74Salivary secretion_Homo sapiens_hsa049700.69508495
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.67102315
76Cholinergic synapse_Homo sapiens_hsa047250.66908545
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66187356
78Glycerolipid metabolism_Homo sapiens_hsa005610.65752814
79Folate biosynthesis_Homo sapiens_hsa007900.65349748
80Alzheimers disease_Homo sapiens_hsa050100.64883180
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64625491
82Insulin resistance_Homo sapiens_hsa049310.64474688
83Morphine addiction_Homo sapiens_hsa050320.64194330
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62029110
85Dopaminergic synapse_Homo sapiens_hsa047280.59411853
86Nicotine addiction_Homo sapiens_hsa050330.57895580
87Glucagon signaling pathway_Homo sapiens_hsa049220.57012312
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56218949
89* cAMP signaling pathway_Homo sapiens_hsa040240.55073434
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54822421
91Galactose metabolism_Homo sapiens_hsa000520.52844064
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51506082
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51492726
94Steroid biosynthesis_Homo sapiens_hsa001000.50994470
95Glutathione metabolism_Homo sapiens_hsa004800.50248723
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49148905
97Metabolic pathways_Homo sapiens_hsa011000.47424117
98Fructose and mannose metabolism_Homo sapiens_hsa000510.46981720
99Pentose phosphate pathway_Homo sapiens_hsa000300.46550666
100Vitamin B6 metabolism_Homo sapiens_hsa007500.43113857
101Tight junction_Homo sapiens_hsa045300.42380252
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42330097
103Vitamin digestion and absorption_Homo sapiens_hsa049770.42137892
104Cocaine addiction_Homo sapiens_hsa050300.41886817
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.41597392
106Pancreatic secretion_Homo sapiens_hsa049720.39593625
107Serotonergic synapse_Homo sapiens_hsa047260.37929240
108Arachidonic acid metabolism_Homo sapiens_hsa005900.36722239
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.35399909
110Huntingtons disease_Homo sapiens_hsa050160.35026693
111Focal adhesion_Homo sapiens_hsa045100.33931150
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31875506
113AMPK signaling pathway_Homo sapiens_hsa041520.31852857
114Insulin signaling pathway_Homo sapiens_hsa049100.31744631
115Melanogenesis_Homo sapiens_hsa049160.29890895
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26744995
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21446815
118Prion diseases_Homo sapiens_hsa050200.18525490
119Viral myocarditis_Homo sapiens_hsa054160.14489633
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.12279759
121Linoleic acid metabolism_Homo sapiens_hsa005910.11009224
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08377878
123Ovarian steroidogenesis_Homo sapiens_hsa049130.05919972
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.05590983
125Circadian rhythm_Homo sapiens_hsa047100.04388957
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.04092683
127Type II diabetes mellitus_Homo sapiens_hsa049300.01508971
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.00652004
129Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0403348
130ECM-receptor interaction_Homo sapiens_hsa04512-0.0391266
131Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0236995
132Calcium signaling pathway_Homo sapiens_hsa04020-0.0140496

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