FXYD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.54023233
2axonemal dynein complex assembly (GO:0070286)8.39107565
3keratinocyte proliferation (GO:0043616)7.46186089
4establishment of skin barrier (GO:0061436)6.99831728
5regulation of water loss via skin (GO:0033561)6.89409736
6viral transcription (GO:0019083)6.53025226
7cilium or flagellum-dependent cell motility (GO:0001539)6.27536651
8ribosomal small subunit biogenesis (GO:0042274)6.25541938
9regulation of phospholipase A2 activity (GO:0032429)6.12497387
10translational termination (GO:0006415)6.12298512
11sphingoid metabolic process (GO:0046519)5.96660273
12motile cilium assembly (GO:0044458)5.60740002
13cilium movement (GO:0003341)5.58483102
14bundle of His cell to Purkinje myocyte communication (GO:0086069)5.33581930
15keratinocyte development (GO:0003334)5.28967200
16ethanol metabolic process (GO:0006067)5.26858075
17negative regulation of keratinocyte proliferation (GO:0010839)5.20429692
18multicellular organismal water homeostasis (GO:0050891)5.20320790
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.07779475
20diterpenoid biosynthetic process (GO:0016102)5.05745092
21vitamin transmembrane transport (GO:0035461)5.03579602
22protein targeting to ER (GO:0045047)5.00487870
23cotranslational protein targeting to membrane (GO:0006613)4.96820039
24keratinization (GO:0031424)4.95995560
25interferon-gamma secretion (GO:0072643)4.90303517
26keratinocyte differentiation (GO:0030216)4.89961767
27calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.87333608
28establishment of protein localization to endoplasmic reticulum (GO:0072599)4.84797458
29sphingosine metabolic process (GO:0006670)4.79090745
30viral life cycle (GO:0019058)4.77251085
31translational elongation (GO:0006414)4.76916032
32ethanol oxidation (GO:0006069)4.74647513
33protein localization to endoplasmic reticulum (GO:0070972)4.64198510
34cellular protein complex disassembly (GO:0043624)4.61542609
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.60233492
36maturation of SSU-rRNA (GO:0030490)4.59810564
37pyrimidine-containing compound transmembrane transport (GO:0072531)4.55209433
38epithelial cilium movement (GO:0003351)4.55027931
39diol metabolic process (GO:0034311)4.50503960
40ribosomal small subunit assembly (GO:0000028)4.43037432
41epidermis development (GO:0008544)4.41755132
42O-glycan processing (GO:0016266)4.39377741
43water homeostasis (GO:0030104)4.38854879
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.33660671
45oligosaccharide biosynthetic process (GO:0009312)4.26700360
46molting cycle (GO:0042303)4.16228707
47hair cycle (GO:0042633)4.16228707
48epidermal cell differentiation (GO:0009913)4.08917594
49regulation of chemokine secretion (GO:0090196)3.99185663
50ribosomal large subunit biogenesis (GO:0042273)3.95076311
51regulation of ruffle assembly (GO:1900027)3.92951203
52intermediate filament organization (GO:0045109)3.91210518
53negative regulation of cell fate commitment (GO:0010454)3.88681242
54axoneme assembly (GO:0035082)3.87000908
55flavonoid metabolic process (GO:0009812)3.86473336
56regulation of cell proliferation involved in kidney development (GO:1901722)3.79035985
57protein complex disassembly (GO:0043241)3.79030001
58glucosamine-containing compound catabolic process (GO:1901072)3.74871869
59sperm capacitation (GO:0048240)3.73318978
60peptide cross-linking (GO:0018149)3.68534689
61gland morphogenesis (GO:0022612)3.67491930
62positive regulation of respiratory burst (GO:0060267)3.65414643
63primary alcohol metabolic process (GO:0034308)3.59437175
64protein targeting to membrane (GO:0006612)3.58485321
65terpenoid biosynthetic process (GO:0016114)3.56733812
66retinol metabolic process (GO:0042572)3.55753574
67translational initiation (GO:0006413)3.55699227
68positive regulation of Cdc42 GTPase activity (GO:0043089)3.54050199
69G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.50018570
70intestinal absorption (GO:0050892)3.49700364
71cellular glucuronidation (GO:0052695)3.49459271
72macromolecular complex disassembly (GO:0032984)3.47210209
73GDP-mannose metabolic process (GO:0019673)3.47066742
74positive regulation of chemokine secretion (GO:0090197)3.45885284
75atrioventricular valve morphogenesis (GO:0003181)3.45521985
76regulation of keratinocyte proliferation (GO:0010837)3.44713651
77positive regulation of interleukin-8 secretion (GO:2000484)3.43076622
78negative regulation of cell fate specification (GO:0009996)3.42755315
79uronic acid metabolic process (GO:0006063)3.39300242
80glucuronate metabolic process (GO:0019585)3.39300242
81glutathione biosynthetic process (GO:0006750)3.38456328
82phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.37636218
83cardiac right ventricle morphogenesis (GO:0003215)3.36183383
84limb bud formation (GO:0060174)3.35865382
85renal filtration (GO:0097205)3.35250137
86sodium ion homeostasis (GO:0055078)3.32233770
87retinoic acid metabolic process (GO:0042573)3.31549136
88regulation of guanylate cyclase activity (GO:0031282)3.31074797
89positive regulation of pseudopodium assembly (GO:0031274)3.31017467
90one-carbon compound transport (GO:0019755)3.30407658
91glomerular filtration (GO:0003094)3.26779968
92detection of bacterium (GO:0016045)3.25638942
93gap junction assembly (GO:0016264)3.25545194
94intestinal epithelial cell development (GO:0060576)3.20079750
95maintenance of gastrointestinal epithelium (GO:0030277)3.19713888
96epoxygenase P450 pathway (GO:0019373)3.19446076
97excretion (GO:0007588)3.19404758
98neural crest cell development (GO:0014032)3.16628263
99heart valve morphogenesis (GO:0003179)3.14609711
100regulation of respiratory burst (GO:0060263)3.13500215
101regulation of interleukin-8 secretion (GO:2000482)3.11134272
102positive regulation of odontogenesis (GO:0042482)3.10389568
103nonribosomal peptide biosynthetic process (GO:0019184)3.09659608
104amyloid precursor protein catabolic process (GO:0042987)3.09264672
105sympathetic nervous system development (GO:0048485)3.08145949
106lateral sprouting from an epithelium (GO:0060601)3.07466005
107skin morphogenesis (GO:0043589)3.06606678
108ectoderm development (GO:0007398)3.05257495
109fatty acid elongation (GO:0030497)3.04268278
110planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02955657
111epithelial cell-cell adhesion (GO:0090136)3.02490860
112regulation of apoptotic process involved in morphogenesis (GO:1902337)3.00713058
113sphingomyelin metabolic process (GO:0006684)3.00377636
114positive regulation of vesicle fusion (GO:0031340)2.99530019
115mesenchymal to epithelial transition (GO:0060231)2.99062635
116establishment of planar polarity (GO:0001736)2.98506053
117establishment of tissue polarity (GO:0007164)2.98506053
118renal system process involved in regulation of blood volume (GO:0001977)2.98280682
119glutathione derivative biosynthetic process (GO:1901687)2.94216272
120glutathione derivative metabolic process (GO:1901685)2.94216272
121regulation of pseudopodium assembly (GO:0031272)2.93449671
122protein O-linked glycosylation (GO:0006493)2.88992065
123negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.88553418
124negative regulation of interleukin-2 production (GO:0032703)2.88338142
125sulfate transmembrane transport (GO:1902358)2.87150811
126positive regulation of epidermis development (GO:0045684)2.86601790
127regulation of transforming growth factor beta1 production (GO:0032908)2.86296536
128negative regulation of kidney development (GO:0090185)2.85551944
129tight junction assembly (GO:0070830)2.83268821
130regulation of metalloenzyme activity (GO:0048552)2.82749308
131COPI coating of Golgi vesicle (GO:0048205)2.81927391
132Golgi transport vesicle coating (GO:0048200)2.81927391
133surfactant homeostasis (GO:0043129)2.81396659
134detection of other organism (GO:0098543)2.80999345
135auditory receptor cell differentiation (GO:0042491)2.80518725
136amyloid precursor protein metabolic process (GO:0042982)2.79897040
137phospholipid scrambling (GO:0017121)2.79475915
138regulation of viral release from host cell (GO:1902186)2.78449153
139regulation of keratinocyte differentiation (GO:0045616)2.76413775
140lymph vessel development (GO:0001945)2.76225792
141hair follicle morphogenesis (GO:0031069)2.76081902
142hypotonic response (GO:0006971)2.75515037
143lung epithelium development (GO:0060428)2.74580057
144regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.74552484
145glutathione metabolic process (GO:0006749)2.74494473
146eyelid development in camera-type eye (GO:0061029)2.73956104
147positive regulation of hair cycle (GO:0042635)2.73257131
148positive regulation of hair follicle development (GO:0051798)2.73257131
149phenylpropanoid metabolic process (GO:0009698)2.73174823
150angiotensin maturation (GO:0002003)2.72616858
151establishment of apical/basal cell polarity (GO:0035089)2.72418267
152transcytosis (GO:0045056)2.71067788
153negative regulation of T cell mediated immunity (GO:0002710)2.71026181
154ventricular cardiac muscle cell action potential (GO:0086005)2.70670497
155regulation of hypersensitivity (GO:0002883)2.70504867
156primary alcohol catabolic process (GO:0034310)2.69507399
157phenol-containing compound catabolic process (GO:0019336)2.69005939
158regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.68876431
159negative regulation of T cell differentiation in thymus (GO:0033085)2.68008017
160left/right pattern formation (GO:0060972)2.67510695
161response to phenylpropanoid (GO:0080184)2.67393949
162bile acid and bile salt transport (GO:0015721)2.65120372
163regulation of hair follicle development (GO:0051797)2.64615992
164negative regulation of interferon-gamma production (GO:0032689)2.63991251
165NADH metabolic process (GO:0006734)2.62749348
166regulation of autophagic vacuole assembly (GO:2000785)2.62304417
167odontogenesis (GO:0042476)2.60498386
168retinal metabolic process (GO:0042574)2.59991860
169phosphatidylserine acyl-chain remodeling (GO:0036150)2.59449536
170negative regulation of stress fiber assembly (GO:0051497)2.58591961
171icosanoid secretion (GO:0032309)2.58458548
172arachidonic acid secretion (GO:0050482)2.58458548
173antimicrobial humoral response (GO:0019730)2.58167935
174regulation of epidermis development (GO:0045682)2.57311779
175regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.56694184
176regulation of vitamin metabolic process (GO:0030656)2.55653376
177regulation of mesonephros development (GO:0061217)2.55433226
178odontogenesis of dentin-containing tooth (GO:0042475)2.55267978
179positive regulation of epidermal cell differentiation (GO:0045606)2.55023198
180drug metabolic process (GO:0017144)2.52713929
181renal absorption (GO:0070293)2.52614843
182desmosome organization (GO:0002934)12.5309160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.47157181
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.53311751
3* SOX9_24532713_ChIP-Seq_HFSC_Mouse3.25596550
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.88094893
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.74175047
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.59313948
7* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.44064110
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33825348
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22805626
10TP63_17297297_ChIP-ChIP_HaCaT_Human14.0579954
11* ESR2_21235772_ChIP-Seq_MCF-7_Human1.97519006
12AR_21572438_ChIP-Seq_LNCaP_Human1.92536219
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83663284
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.80919742
15SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.80919742
16SOX2_20726797_ChIP-Seq_SW620_Human1.69023163
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68395865
18* RXR_22158963_ChIP-Seq_LIVER_Mouse1.68175132
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66846624
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62602713
21* LXR_22292898_ChIP-Seq_THP-1_Human1.60549125
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.59634657
23* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.58733242
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58308799
25CJUN_26792858_Chip-Seq_BT549_Human1.42487239
26AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42098092
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.39719743
28TP53_18474530_ChIP-ChIP_U2OS_Human1.38895708
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.38849657
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36569536
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35094163
32TP53_20018659_ChIP-ChIP_R1E_Mouse1.31952900
33AHR_22903824_ChIP-Seq_MCF-7_Human1.31934297
34CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30767022
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28606064
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.27993045
37ZNF263_19887448_ChIP-Seq_K562_Human1.26205868
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25968036
39* KLF5_25053715_ChIP-Seq_YYC3_Human1.25170753
40SMC4_20622854_ChIP-Seq_HELA_Human1.24455957
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23835886
42TCF4_18268006_ChIP-ChIP_LS174T_Human1.23285144
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23045029
44BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.22854063
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22366245
46* TP63_23658742_ChIP-Seq_EP156T_Human1.21574255
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21204895
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20877964
49FOXA1_25552417_ChIP-Seq_VCAP_Human1.20860858
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20340894
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18428600
52* LXR_22158963_ChIP-Seq_LIVER_Mouse1.18380510
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.17970378
54CLOCK_20551151_ChIP-Seq_293T_Human1.17136935
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16041964
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15787797
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15756448
58CREB1_26743006_Chip-Seq_LNCaP_Human1.12980251
59GATA4_25053715_ChIP-Seq_YYC3_Human1.12838471
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12209954
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11138655
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09921294
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09755905
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09217462
65DROSHA_22980978_ChIP-Seq_HELA_Human1.08715410
66JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06824200
67* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06412330
68RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06366505
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06289615
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05937192
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05274199
72CTCF_27219007_Chip-Seq_Bcells_Human1.05231191
73RXR_22108803_ChIP-Seq_LS180_Human1.04114597
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04062498
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03959737
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03959737
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02437920
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.02104517
79BCAT_22108803_ChIP-Seq_LS180_Human1.01792183
80EZH2_27294783_Chip-Seq_ESCs_Mouse0.99995187
81GATA1_22025678_ChIP-Seq_K562_Human0.99928917
82STAT1_20625510_ChIP-Seq_HELA_Human0.99669056
83* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99659005
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99464518
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99312511
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98824640
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.98811806
88BCOR_27268052_Chip-Seq_Bcells_Human0.98724226
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97787219
90FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97671446
91TP53_16413492_ChIP-PET_HCT116_Human0.96950304
92TP63_22573176_ChIP-Seq_HFKS_Human0.96146881
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96053367
94P68_20966046_ChIP-Seq_HELA_Human0.95519711
95SA1_27219007_Chip-Seq_Bcells_Human0.95218372
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.95172354
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95141660
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.93683274
99SA1_27219007_Chip-Seq_ERYTHROID_Human0.92597239
100E2F1_20622854_ChIP-Seq_HELA_Human0.92146087
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92036371
102ELF5_23300383_ChIP-Seq_T47D_Human0.92019410
103GATA3_24758297_ChIP-Seq_MCF-7_Human0.91002958
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90602779
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90076773
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88938723
107ERG_21242973_ChIP-ChIP_JURKAT_Human0.88813069
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88000029
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87944449
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.87325552
111PHF8_20622854_ChIP-Seq_HELA_Human0.87209287
112TET1_21451524_ChIP-Seq_MESCs_Mouse0.86156183
113ELK3_25401928_ChIP-Seq_HUVEC_Human0.84473570
114EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84192204
115* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84168908
116RACK7_27058665_Chip-Seq_MCF-7_Human0.83355318
117FOXA2_19822575_ChIP-Seq_HepG2_Human0.83288239
118GATA6_25053715_ChIP-Seq_YYC3_Human0.83272924
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83149549
120SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82873474
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82781805
122CTCF_20526341_ChIP-Seq_ESCs_Human0.82311555
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.81605703
124UBF1/2_26484160_Chip-Seq_HMECs_Human0.81060867
125FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80572993
126CEBPB_22108803_ChIP-Seq_LS180_Human0.79780791
127BCL6_27268052_Chip-Seq_Bcells_Human0.79061035
128P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.78830214
129TCF4_22108803_ChIP-Seq_LS180_Human0.78683806
130MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78636588
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78542723
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77993014
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76860792
134GATA1_19941826_ChIP-Seq_K562_Human0.76414775
135P300_27268052_Chip-Seq_Bcells_Human0.75963248
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.75261632
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74941571
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74941571
139EGR1_19032775_ChIP-ChIP_M12_Human0.71253963
140GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.70257571
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69042221
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67007436
143RNF2_27304074_Chip-Seq_NSC_Mouse0.63658416
144EP300_21415370_ChIP-Seq_HL-1_Mouse0.63194989
145ATF3_27146783_Chip-Seq_COLON_Human0.62849705
146RING1B_27294783_Chip-Seq_NPCs_Mouse0.62657749
147GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.62546784
148KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.62170887
149KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.62170887
150KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.62170887
151FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61513511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.83186746
2MP0010234_abnormal_vibrissa_follicle5.31798079
3MP0004381_abnormal_hair_follicle4.56586799
4MP0003941_abnormal_skin_development4.36057747
5MP0002254_reproductive_system_inflammat4.14822165
6MP0005501_abnormal_skin_physiology3.45161593
7MP0005275_abnormal_skin_tensile3.44026396
8MP0000383_abnormal_hair_follicle3.43537302
9MP0002098_abnormal_vibrissa_morphology3.35067476
10MP0002060_abnormal_skin_morphology3.34291619
11MP0010678_abnormal_skin_adnexa3.29770372
12MP0004043_abnormal_pH_regulation3.17753888
13MP0002139_abnormal_hepatobiliary_system3.11428422
14MP0000579_abnormal_nail_morphology3.00022831
15MP0001216_abnormal_epidermal_layer2.99565119
16MP0001346_abnormal_lacrimal_gland2.95901871
17MP0009379_abnormal_foot_pigmentation2.84406111
18MP0008875_abnormal_xenobiotic_pharmacok2.78409931
19MP0000647_abnormal_sebaceous_gland2.75727543
20MP0002009_preneoplasia2.75192253
21MP0003453_abnormal_keratinocyte_physiol2.75015349
22MP0010771_integument_phenotype2.53305594
23MP0000377_abnormal_hair_follicle2.47466435
24MP0000566_synostosis2.42148512
25MP0003136_yellow_coat_color2.35793675
26MP0000467_abnormal_esophagus_morphology2.28686961
27MP0000762_abnormal_tongue_morphology2.20087766
28MP0000427_abnormal_hair_cycle2.13548220
29MP0001765_abnormal_ion_homeostasis2.08533266
30MP0010155_abnormal_intestine_physiology2.01869810
31MP0003866_abnormal_defecation1.98710408
32MP0005085_abnormal_gallbladder_physiolo1.88272832
33MP0005360_urolithiasis1.79940517
34MP0003011_delayed_dark_adaptation1.77584143
35MP0000537_abnormal_urethra_morphology1.75138347
36MP0001664_abnormal_digestion1.73814223
37MP0004947_skin_inflammation1.70439021
38MP0003566_abnormal_cell_adhesion1.70133569
39MP0005365_abnormal_bile_salt1.60915925
40MP0005083_abnormal_biliary_tract1.49874017
41MP0005451_abnormal_body_composition1.49718433
42MP0000477_abnormal_intestine_morphology1.46317462
43MP0005636_abnormal_mineral_homeostasis1.46082160
44MP0008004_abnormal_stomach_pH1.45298549
45MP0003705_abnormal_hypodermis_morpholog1.45088705
46MP0001191_abnormal_skin_condition1.41307300
47MP0001851_eye_inflammation1.41033884
48MP0002249_abnormal_larynx_morphology1.40457663
49MP0009643_abnormal_urine_homeostasis1.37992084
50MP0010030_abnormal_orbit_morphology1.35207113
51MP0009931_abnormal_skin_appearance1.33416606
52MP0009384_cardiac_valve_regurgitation1.32623012
53MP0003806_abnormal_nucleotide_metabolis1.31228551
54MP0000490_abnormal_crypts_of1.30699315
55MP0001340_abnormal_eyelid_morphology1.23358092
56MP0003183_abnormal_peptide_metabolism1.23114124
57MP0000516_abnormal_urinary_system1.21457699
58MP0005367_renal/urinary_system_phenotyp1.21457699
59MP0003191_abnormal_cellular_cholesterol1.19259259
60MP0003315_abnormal_perineum_morphology1.18893362
61MP0000367_abnormal_coat/_hair1.18693404
62MP0005408_hypopigmentation1.17446594
63MP0002282_abnormal_trachea_morphology1.16368479
64MP0001663_abnormal_digestive_system1.15162478
65MP0002909_abnormal_adrenal_gland1.14580719
66MP0001243_abnormal_dermal_layer1.13636500
67MP0001756_abnormal_urination1.13424678
68MP0004019_abnormal_vitamin_homeostasis1.11908788
69MP0008789_abnormal_olfactory_epithelium1.09466079
70MP0005381_digestive/alimentary_phenotyp1.07968673
71MP0004272_abnormal_basement_membrane1.07823909
72MP0004185_abnormal_adipocyte_glucose1.04848111
73MP0000627_abnormal_mammary_gland1.04636949
74MP0005165_increased_susceptibility_to1.04130284
75MP0002277_abnormal_respiratory_mucosa1.04039149
76MP0002136_abnormal_kidney_physiology1.02202367
77MP0002233_abnormal_nose_morphology0.97963098
78MP0005166_decreased_susceptibility_to0.97954216
79MP0002234_abnormal_pharynx_morphology0.97775835
80MP0002876_abnormal_thyroid_physiology0.96779036
81MP0009250_abnormal_appendicular_skeleto0.95795191
82MP0010352_gastrointestinal_tract_polyps0.92594211
83MP0000462_abnormal_digestive_system0.92432716
84MP0000538_abnormal_urinary_bladder0.89371540
85MP0009840_abnormal_foam_cell0.88131154
86MP0002653_abnormal_ependyma_morphology0.87411466
87MP0005508_abnormal_skeleton_morphology0.86304335
88MP0009053_abnormal_anal_canal0.83430022
89MP0004264_abnormal_extraembryonic_tissu0.82541537
90MP0002132_abnormal_respiratory_system0.82080313
91MP0000465_gastrointestinal_hemorrhage0.81681144
92MP0001849_ear_inflammation0.80806888
93MP0000613_abnormal_salivary_gland0.80791861
94MP0003755_abnormal_palate_morphology0.80329134
95MP0002166_altered_tumor_susceptibility0.76421877
96MP0005187_abnormal_penis_morphology0.76254198
97MP0000049_abnormal_middle_ear0.75949052
98MP0005023_abnormal_wound_healing0.75314557
99MP0003868_abnormal_feces_composition0.75299279
100MP0000858_altered_metastatic_potential0.75023265
101MP0005499_abnormal_olfactory_system0.73519446
102MP0005394_taste/olfaction_phenotype0.73519446
103MP0001881_abnormal_mammary_gland0.73501196
104MP0002006_tumorigenesis0.71949766
105MP0005058_abnormal_lysosome_morphology0.69234565
106MP0001666_abnormal_nutrient_absorption0.68585528
107MP0002177_abnormal_outer_ear0.67955776
108MP0004147_increased_porphyrin_level0.67953527
109MP0000470_abnormal_stomach_morphology0.67766437
110MP0000013_abnormal_adipose_tissue0.67703211
111MP0005310_abnormal_salivary_gland0.67374817
112MP0004858_abnormal_nervous_system0.67165536
113MP0001919_abnormal_reproductive_system0.66895333
114MP0002877_abnormal_melanocyte_morpholog0.65722537
115MP0004782_abnormal_surfactant_physiolog0.64555332
116MP0005319_abnormal_enzyme/_coenzyme0.62327428
117MP0000678_abnormal_parathyroid_gland0.60138947
118MP0000163_abnormal_cartilage_morphology0.57267570
119MP0003936_abnormal_reproductive_system0.56308355
120MP0000372_irregular_coat_pigmentation0.54960668
121MP0005076_abnormal_cell_differentiation0.54608984
122MP0003045_fibrosis0.54059167
123MP0002896_abnormal_bone_mineralization0.53500853
124MP0005409_darkened_coat_color0.53325082
125MP0003638_abnormal_response/metabolism_0.53256361
126MP0003938_abnormal_ear_development0.53078652
127MP0000681_abnormal_thyroid_gland0.53024345
128MP0005332_abnormal_amino_acid0.52787955
129MP0003300_gastrointestinal_ulcer0.51644538
130MP0002168_other_aberrant_phenotype0.51347797
131MP0010329_abnormal_lipoprotein_level0.50652146
132MP0000432_abnormal_head_morphology0.50330070
133MP0002118_abnormal_lipid_homeostasis0.49891125
134MP0008872_abnormal_physiological_respon0.49114404
135MP0005390_skeleton_phenotype0.48774445
136MP0010386_abnormal_urinary_bladder0.46430428
137MP0009780_abnormal_chondrocyte_physiolo0.45254257
138MP0001873_stomach_inflammation0.44051877
139MP0001270_distended_abdomen0.43558675
140MP0002111_abnormal_tail_morphology0.41865343
141MP0005248_abnormal_Harderian_gland0.41773998
142MP0003385_abnormal_body_wall0.39718453
143MP0002109_abnormal_limb_morphology0.39608735
144MP0002163_abnormal_gland_morphology0.38375638
145MP0005379_endocrine/exocrine_gland_phen0.37806276

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.47828340
2Hyperactive renin-angiotensin system (HP:0000841)7.16783139
3Fragile nails (HP:0001808)6.60444958
4Chronic bronchitis (HP:0004469)6.45716625
5Abnormal respiratory motile cilium morphology (HP:0005938)6.36953960
6Abnormal respiratory epithelium morphology (HP:0012253)6.36953960
7Abnormal respiratory motile cilium physiology (HP:0012261)6.33225394
8Onycholysis (HP:0001806)6.11648712
9Rhinitis (HP:0012384)6.05974256
10Abnormal ciliary motility (HP:0012262)6.01082861
11Absent/shortened dynein arms (HP:0200106)5.96820768
12Dynein arm defect of respiratory motile cilia (HP:0012255)5.96820768
13Hypotrichosis (HP:0001006)5.95724565
14Plantar hyperkeratosis (HP:0007556)5.62893136
15Parakeratosis (HP:0001036)5.54451092
16Lip pit (HP:0100267)5.17956621
17Woolly hair (HP:0002224)5.17288613
18Right ventricular cardiomyopathy (HP:0011663)5.13004760
19Bronchiectasis (HP:0002110)4.92056122
20Milia (HP:0001056)4.84408209
21Decreased circulating renin level (HP:0003351)4.82331056
22Nasal polyposis (HP:0100582)4.80679363
23Abnormality of cells of the erythroid lineage (HP:0012130)4.61243888
24Abnormality of the axillary hair (HP:0100134)4.39781829
25Abnormality of secondary sexual hair (HP:0009888)4.39781829
26Abnormality of the nasal mucosa (HP:0000433)4.33328146
27Abnormality of renin-angiotensin system (HP:0000847)4.18106372
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.11917559
29Palmoplantar hyperkeratosis (HP:0000972)4.08583819
30Congenital ichthyosiform erythroderma (HP:0007431)4.08317048
31Reticulocytopenia (HP:0001896)4.07135926
32Concave nail (HP:0001598)3.98374304
33Abnormal hemoglobin (HP:0011902)3.88227658
34Increased IgE level (HP:0003212)3.83934502
35Abnormal number of erythroid precursors (HP:0012131)3.81379896
36Palmar hyperkeratosis (HP:0010765)3.80397277
37Flat acetabular roof (HP:0003180)3.68083841
38Abnormal blistering of the skin (HP:0008066)3.51325888
39Hyperaldosteronism (HP:0000859)3.50342957
40Atrophic scars (HP:0001075)3.49075184
41Erythema (HP:0010783)3.45474161
42Abnormality of chloride homeostasis (HP:0011422)3.44721014
43Bronchitis (HP:0012387)3.40220666
44Popliteal pterygium (HP:0009756)3.39888496
45Pili torti (HP:0003777)3.39800347
46Sparse scalp hair (HP:0002209)3.39066094
47Malnutrition (HP:0004395)3.32193252
48Aplasia cutis congenita (HP:0001057)3.22986057
49Sparse eyelashes (HP:0000653)3.17587738
50Nail dystrophy (HP:0008404)3.09049871
51Natal tooth (HP:0000695)3.08953443
52Acanthosis nigricans (HP:0000956)3.07634933
53Abnormality of nail color (HP:0100643)3.05986369
54Hyperkalemia (HP:0002153)3.01566641
55Down-sloping shoulders (HP:0200021)2.97391011
56Oligodontia (HP:0000677)2.92849987
57Distal lower limb muscle weakness (HP:0009053)2.92588737
58Macrocytic anemia (HP:0001972)2.91362965
59Hyponatremia (HP:0002902)2.83664251
60Alkalosis (HP:0001948)2.83324546
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.83233813
62Ridged nail (HP:0001807)2.81734859
63Erythroderma (HP:0001019)2.78886258
64Anhidrosis (HP:0000970)2.77240353
65Renal salt wasting (HP:0000127)2.72443169
66Metabolic alkalosis (HP:0200114)2.71479999
67Aplasia involving bones of the upper limbs (HP:0009823)2.69543335
68Aplasia of the phalanges of the hand (HP:0009802)2.69543335
69Aplasia involving bones of the extremities (HP:0009825)2.69543335
70Chronic sinusitis (HP:0011109)2.67628349
71Congenital, generalized hypertrichosis (HP:0004540)2.66549413
72Absent eyebrow (HP:0002223)2.65403337
73Hypoplasia of dental enamel (HP:0006297)2.64653752
74Advanced eruption of teeth (HP:0006288)2.63606823
75Hypohidrosis (HP:0000966)2.61812626
76Pterygium (HP:0001059)2.61376721
77Hypoplastic labia majora (HP:0000059)2.59417038
78Pallor (HP:0000980)2.54809734
79Conical tooth (HP:0000698)2.51777265
80Recurrent otitis media (HP:0000403)2.51752515
81Abnormality of the 2nd finger (HP:0004100)2.48077018
82Hypodontia (HP:0000668)2.47862649
83Ectropion (HP:0000656)2.47593724
84Thick nail (HP:0001805)2.46920375
85Infertility (HP:0000789)2.44581950
86Stenosis of the external auditory canal (HP:0000402)2.43723597
87Male infertility (HP:0003251)2.42134341
88Curly hair (HP:0002212)2.41645864
89Alopecia of scalp (HP:0002293)2.41116429
90Corneal erosion (HP:0200020)2.37595541
91Abnormality of glutamine family amino acid metabolism (HP:0010902)2.37214764
92Abnormality of the labia majora (HP:0012881)2.35926582
93Recurrent sinusitis (HP:0011108)2.31397774
94Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.31029400
95Vascular calcification (HP:0004934)2.29093737
96Spinal cord compression (HP:0002176)2.26948949
97Abnormality of the phalanges of the 5th finger (HP:0004213)2.19468792
98Premature loss of primary teeth (HP:0006323)2.19432014
99Abdominal distention (HP:0003270)2.18722627
100Nasolacrimal duct obstruction (HP:0000579)2.18150395
101Hyporeflexia of lower limbs (HP:0002600)2.16964193
102Abnormality of sodium homeostasis (HP:0010931)2.16642081
103Ventricular tachycardia (HP:0004756)2.16524284
104Abnormality of the middle phalanges of the toes (HP:0010183)2.14926046
105Abnormality of the distal phalanges of the toes (HP:0010182)2.14827246
106Fragile skin (HP:0001030)2.12442955
107Abnormal hair laboratory examination (HP:0003328)2.11833536
108Sex reversal (HP:0012245)2.11765721
109Abnormal sex determination (HP:0012244)2.11765721
110Abnormality of the dental root (HP:0006486)2.11107428
111Taurodontia (HP:0000679)2.11107428
112Abnormality of permanent molar morphology (HP:0011071)2.11107428
113Bifid scrotum (HP:0000048)2.09482222
114Pruritus (HP:0000989)2.09424184
115Abnormality of the gastric mucosa (HP:0004295)2.05163498
116Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.04779921
117Atelectasis (HP:0100750)2.01835767
118Abnormality of the nasal septum (HP:0000419)2.00988380
119Absent hair (HP:0002298)2.00585080
120Chronic otitis media (HP:0000389)1.99509042
121Abnormality of the lacrimal duct (HP:0011481)1.98191074
122Hypotension (HP:0002615)1.96564340
123Synostosis involving the elbow (HP:0003938)1.96355268
124Humeroradial synostosis (HP:0003041)1.96355268
125Amelogenesis imperfecta (HP:0000705)1.96144503
126Bronchomalacia (HP:0002780)1.95386583
127Severe Myopia (HP:0011003)1.93982031
128Adrenal overactivity (HP:0002717)1.93588209
129Abnormality of molar (HP:0011077)1.92299599
130Abnormality of molar morphology (HP:0011070)1.92299599
131Symphalangism affecting the phalanges of the hand (HP:0009773)1.92185583
132Cardiovascular calcification (HP:0011915)1.91369736
133Flattened epiphyses (HP:0003071)1.89817362
134Abnormality of the salivary glands (HP:0010286)1.89290670
135Hyperparathyroidism (HP:0000843)1.88614464
136Villous atrophy (HP:0011473)1.88487266
137Abnormality of small intestinal villus morphology (HP:0011472)1.88487266
138Septate vagina (HP:0001153)1.87556801
13911 pairs of ribs (HP:0000878)1.87432228
140Esophageal atresia (HP:0002032)1.85858212
141Palmoplantar keratoderma (HP:0000982)1.85455830
142Syncope (HP:0001279)1.84854776
143Abnormality of the dental pulp (HP:0006479)1.83863366
144Dehydration (HP:0001944)1.83558743
145Xerostomia (HP:0000217)1.82489802
146Type I diabetes mellitus (HP:0100651)1.82307564
147Intrahepatic cholestasis (HP:0001406)1.81857011
148Brittle hair (HP:0002299)1.81550268
149Abnormality of potassium homeostasis (HP:0011042)1.81521382
150Pustule (HP:0200039)1.81273511
151Hyperphosphatemia (HP:0002905)1.79623836
152Upper limb muscle weakness (HP:0003484)1.78016122
153Blepharitis (HP:0000498)1.77967591
154Morphological abnormality of the middle ear (HP:0008609)1.77798539
155Hypokalemia (HP:0002900)1.76050213
156Hypoparathyroidism (HP:0000829)1.75985761
157Fat malabsorption (HP:0002630)1.75604748
158Abnormality of carpal bone ossification (HP:0006257)1.74024104
159Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70534921
160Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.68705149
161Growth hormone excess (HP:0000845)1.66107050
162Ileus (HP:0002595)1.64470563
163Conjugated hyperbilirubinemia (HP:0002908)1.62135624
164Focal segmental glomerulosclerosis (HP:0000097)1.61315805
165Glomerulosclerosis (HP:0000096)1.59284408
166Hemorrhage of the eye (HP:0011885)1.58722993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.92186991
2MST43.92807427
3EPHB23.85911685
4MAP3K33.74646623
5MAPKAPK33.43119584
6FER3.02414665
7RIPK12.97515480
8MAP3K22.87157096
9RPS6KB22.37827463
10LATS12.28291361
11MAP3K122.23706112
12EPHA22.21095128
13TRPM72.12576729
14ACVR1B2.02035596
15LRRK21.95059337
16ERN11.94922926
17MET1.93798256
18TRIB31.92002672
19SMG11.82057501
20STK241.78271590
21EPHA31.72048338
22BCR1.63806858
23PIK3CG1.61587924
24MAPK151.61344089
25ERBB31.46980583
26FGFR21.45546803
27BMPR1B1.42940471
28MAP2K21.30140920
29PAK41.28868274
30MAPKAPK51.25484707
31GRK11.21800123
32NME21.20942731
33PBK1.19910411
34PIM21.19404777
35FRK1.14730439
36MYLK1.13641292
37CASK1.09675835
38STK101.08920764
39ARAF1.03315975
40PTK61.01446761
41PRKG20.99752317
42CDK30.96327899
43FGFR40.96217451
44TAOK10.93069736
45TNK20.92115876
46TESK10.91049735
47HIPK20.87989380
48MAP3K10.86739972
49DYRK1B0.86265072
50NUAK10.81677047
51TYK20.81561164
52PKN20.80971323
53INSRR0.80607857
54EPHB10.78149184
55STK38L0.78137234
56ABL20.78104667
57STK390.77833577
58NEK60.76808102
59MAP3K140.76268908
60GRK60.75077495
61GRK70.69575811
62TGFBR10.69132271
63MAP2K60.69053505
64TBK10.68612047
65ERBB20.67900610
66CDC42BPA0.67514650
67PDPK10.66550414
68IKBKB0.65307080
69CDK60.64455143
70PRKD10.63739972
71FGFR30.63729605
72IRAK30.63336618
73TGFBR20.63286271
74MAP2K10.62452525
75PRKCE0.61783727
76NLK0.61525464
77MAPKAPK20.61290516
78SIK10.61150088
79ERBB40.60658619
80EEF2K0.57202562
81RIPK40.55553518
82EIF2AK20.55390146
83BMPR20.55044912
84IRAK10.54638709
85EPHA40.54054997
86LMTK20.53500439
87MAP3K60.51457694
88CDK190.49711156
89WNK40.48882759
90STK30.48004616
91YES10.46131333
92PRKD20.46095394
93IKBKE0.45830536
94BLK0.45700095
95CAMK2G0.45473458
96STK380.45470556
97ADRBK10.45328455
98MATK0.44931737
99ROCK10.44523875
100PIK3CA0.43636045
101MUSK0.41246814
102NME10.39522336
103ZAP700.38656535
104PTK20.38283306
105CSK0.37208373
106RPS6KA10.36060404
107RPS6KC10.35488321
108RPS6KL10.35488321
109TESK20.34822302
110PRKAA20.34005665
111ILK0.33979194
112OXSR10.33976541
113CAMK2D0.33215319
114PRKCD0.32815168
115PRKCI0.32147451
116RPS6KA20.32137513
117LATS20.31982657
118JAK20.31803761
119PHKG10.31724912
120PHKG20.31724912
121PAK30.30863067
122MAP3K70.30791434
123ITK0.30718003
124SCYL20.29685743
125CHUK0.29508114
126MAPK110.29360378
127DYRK1A0.27209051
128ABL10.27121772
129DMPK0.26865706
130IGF1R0.26815046
131SRC0.26554654
132STK110.26392907
133RET0.26372138
134DDR20.26328911
135NTRK10.20985780
136PRKCA0.19248123
137ROCK20.18634012
138CSNK1A10.17798895
139BMX0.17645819
140ICK0.15215018
141EIF2AK10.14042982

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.81807046
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.85490714
3Sphingolipid metabolism_Homo sapiens_hsa006002.86087744
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.53132198
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.50887106
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.47863621
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47404785
8Basal cell carcinoma_Homo sapiens_hsa052172.32746450
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.23704033
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22104062
11Nitrogen metabolism_Homo sapiens_hsa009102.21034642
12Retinol metabolism_Homo sapiens_hsa008302.16610555
13Fatty acid elongation_Homo sapiens_hsa000622.13992792
14Chemical carcinogenesis_Homo sapiens_hsa052042.13405993
15Linoleic acid metabolism_Homo sapiens_hsa005912.10609938
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05612020
17Phenylalanine metabolism_Homo sapiens_hsa003601.97417977
18Arachidonic acid metabolism_Homo sapiens_hsa005901.86936458
19Histidine metabolism_Homo sapiens_hsa003401.81747180
20Arginine biosynthesis_Homo sapiens_hsa002201.80746719
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.79385092
22ECM-receptor interaction_Homo sapiens_hsa045121.75579725
23Fructose and mannose metabolism_Homo sapiens_hsa000511.62034171
24Starch and sucrose metabolism_Homo sapiens_hsa005001.50762069
25Hippo signaling pathway_Homo sapiens_hsa043901.43599469
26Hedgehog signaling pathway_Homo sapiens_hsa043401.42883845
27Fatty acid biosynthesis_Homo sapiens_hsa000611.32538151
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31915244
29Adherens junction_Homo sapiens_hsa045201.28825923
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28452309
31Tyrosine metabolism_Homo sapiens_hsa003501.25477000
32Glutathione metabolism_Homo sapiens_hsa004801.24980751
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23665941
34Tight junction_Homo sapiens_hsa045301.23355190
35Melanogenesis_Homo sapiens_hsa049161.21581016
36Bladder cancer_Homo sapiens_hsa052191.20338618
37Caffeine metabolism_Homo sapiens_hsa002321.20160884
38Mineral absorption_Homo sapiens_hsa049781.18350381
39Sulfur metabolism_Homo sapiens_hsa009201.17608160
40Ether lipid metabolism_Homo sapiens_hsa005651.15806021
41Renin-angiotensin system_Homo sapiens_hsa046141.15257257
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15033029
43Bile secretion_Homo sapiens_hsa049761.14876162
44TGF-beta signaling pathway_Homo sapiens_hsa043501.10668279
45Other glycan degradation_Homo sapiens_hsa005111.09861309
46Protein digestion and absorption_Homo sapiens_hsa049741.09643132
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09604699
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08894512
49Axon guidance_Homo sapiens_hsa043601.06713103
50Arginine and proline metabolism_Homo sapiens_hsa003301.06466779
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06156733
52Pancreatic secretion_Homo sapiens_hsa049721.04079087
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02138371
54Proteoglycans in cancer_Homo sapiens_hsa052051.01626721
55Galactose metabolism_Homo sapiens_hsa000520.97657442
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97574528
57Amoebiasis_Homo sapiens_hsa051460.96478418
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95644120
59Gastric acid secretion_Homo sapiens_hsa049710.94152173
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92520392
61Phototransduction_Homo sapiens_hsa047440.90999561
62Sulfur relay system_Homo sapiens_hsa041220.84053435
63Wnt signaling pathway_Homo sapiens_hsa043100.83164075
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79456631
65Vibrio cholerae infection_Homo sapiens_hsa051100.79454981
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.77973278
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.77912220
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77755939
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.77519388
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76242240
71Fat digestion and absorption_Homo sapiens_hsa049750.74343151
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72519821
73beta-Alanine metabolism_Homo sapiens_hsa004100.72353395
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71862281
75Hepatitis C_Homo sapiens_hsa051600.71677771
76Peroxisome_Homo sapiens_hsa041460.67264307
77Renin secretion_Homo sapiens_hsa049240.67261358
78Tryptophan metabolism_Homo sapiens_hsa003800.66787307
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66585210
80Fatty acid degradation_Homo sapiens_hsa000710.64508046
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.63161046
82Vitamin digestion and absorption_Homo sapiens_hsa049770.62535389
83Glycerolipid metabolism_Homo sapiens_hsa005610.62005092
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.61892105
85Toxoplasmosis_Homo sapiens_hsa051450.61408756
86Huntingtons disease_Homo sapiens_hsa050160.60924160
87Small cell lung cancer_Homo sapiens_hsa052220.60579046
88Salivary secretion_Homo sapiens_hsa049700.58311050
89Thyroid cancer_Homo sapiens_hsa052160.57766995
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57263914
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56589401
92p53 signaling pathway_Homo sapiens_hsa041150.55754081
93Collecting duct acid secretion_Homo sapiens_hsa049660.55435904
94Melanoma_Homo sapiens_hsa052180.54584113
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.54560865
96Hematopoietic cell lineage_Homo sapiens_hsa046400.53872437
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53516692
98Lysosome_Homo sapiens_hsa041420.53511422
99MicroRNAs in cancer_Homo sapiens_hsa052060.52151337
100Ras signaling pathway_Homo sapiens_hsa040140.51003967
101Pertussis_Homo sapiens_hsa051330.50528558
102Pathways in cancer_Homo sapiens_hsa052000.50213715
103Oxidative phosphorylation_Homo sapiens_hsa001900.48847634
104Rap1 signaling pathway_Homo sapiens_hsa040150.48841406
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48258250
106Ovarian steroidogenesis_Homo sapiens_hsa049130.47947697
107ABC transporters_Homo sapiens_hsa020100.47741928
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47574776
109GnRH signaling pathway_Homo sapiens_hsa049120.46387124
110Fatty acid metabolism_Homo sapiens_hsa012120.45462575
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45419573
112VEGF signaling pathway_Homo sapiens_hsa043700.42417731
113Focal adhesion_Homo sapiens_hsa045100.42178870
114Metabolic pathways_Homo sapiens_hsa011000.41274769
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40166483
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.37144428
117Folate biosynthesis_Homo sapiens_hsa007900.36700339
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35530919
119Insulin resistance_Homo sapiens_hsa049310.35475191
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35209669
121Alzheimers disease_Homo sapiens_hsa050100.34869998
122Steroid biosynthesis_Homo sapiens_hsa001000.34017686
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33277550
124N-Glycan biosynthesis_Homo sapiens_hsa005100.33267401
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33110995
126Serotonergic synapse_Homo sapiens_hsa047260.32442082
127Prostate cancer_Homo sapiens_hsa052150.30601769
128PPAR signaling pathway_Homo sapiens_hsa033200.29769765
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.29485709
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29384099
131ErbB signaling pathway_Homo sapiens_hsa040120.28794988
132Circadian rhythm_Homo sapiens_hsa047100.28477879
133Malaria_Homo sapiens_hsa051440.27547712
134Notch signaling pathway_Homo sapiens_hsa043300.27145163
135Calcium signaling pathway_Homo sapiens_hsa040200.27100483
136Endocytosis_Homo sapiens_hsa041440.25822407
137Prolactin signaling pathway_Homo sapiens_hsa049170.24875712
138Endometrial cancer_Homo sapiens_hsa052130.24875649
139Choline metabolism in cancer_Homo sapiens_hsa052310.23618464
140Dorso-ventral axis formation_Homo sapiens_hsa043200.23380444
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21749203
142Butanoate metabolism_Homo sapiens_hsa006500.19715223
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14655050
144Pentose phosphate pathway_Homo sapiens_hsa000300.14125986
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.13165373
146Thyroid hormone synthesis_Homo sapiens_hsa049180.12963077
147Salmonella infection_Homo sapiens_hsa051320.12492080
148Pyruvate metabolism_Homo sapiens_hsa006200.11580101
149Primary bile acid biosynthesis_Homo sapiens_hsa001200.09953637

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