FXYD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of retinoic acid receptor signaling pathway (GO:0048385)8.67827977
2peptidyl-arginine modification (GO:0018195)6.84768058
3citrulline metabolic process (GO:0000052)6.83568272
4folic acid transport (GO:0015884)5.99034603
5phosphatidylserine acyl-chain remodeling (GO:0036150)5.23876009
6regulation of oxidative phosphorylation (GO:0002082)5.13150860
7polyol transport (GO:0015791)5.12720602
8phosphatidylinositol acyl-chain remodeling (GO:0036149)5.08800203
9vitamin transmembrane transport (GO:0035461)5.07146902
10lipoxygenase pathway (GO:0019372)5.05227172
11glucuronate metabolic process (GO:0019585)5.03087096
12uronic acid metabolic process (GO:0006063)5.03087096
13nucleotide-sugar biosynthetic process (GO:0009226)5.02035221
14interferon-gamma secretion (GO:0072643)4.90604984
15cyclooxygenase pathway (GO:0019371)4.85567783
16modified amino acid transport (GO:0072337)4.77140942
17iron ion import (GO:0097286)4.66965265
18cellular glucuronidation (GO:0052695)4.66712755
19cGMP-mediated signaling (GO:0019934)4.65823750
20thrombin receptor signaling pathway (GO:0070493)4.52385401
21response to water (GO:0009415)4.47349176
22benzene-containing compound metabolic process (GO:0042537)4.46298289
23glutathione derivative biosynthetic process (GO:1901687)4.36645358
24glutathione derivative metabolic process (GO:1901685)4.36645358
25regulation of cellular respiration (GO:0043457)4.31707812
26phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.29739906
27response to parathyroid hormone (GO:0071107)4.17461792
28ribosomal small subunit biogenesis (GO:0042274)4.17376399
29sodium ion homeostasis (GO:0055078)4.15305306
30negative regulation of keratinocyte proliferation (GO:0010839)4.12245855
31ectoderm development (GO:0007398)4.11868360
32ribosomal small subunit assembly (GO:0000028)4.10614775
33urate metabolic process (GO:0046415)4.04243354
34aggressive behavior (GO:0002118)4.03177997
35chaperone-mediated protein transport (GO:0072321)4.03010370
36response to mercury ion (GO:0046689)4.02531284
37pyrimidine-containing compound transmembrane transport (GO:0072531)3.96288712
38renal absorption (GO:0070293)3.95941087
39viral transcription (GO:0019083)3.95217121
40sphingomyelin metabolic process (GO:0006684)3.89005164
41phosphatidylserine metabolic process (GO:0006658)3.88624507
42translational termination (GO:0006415)3.86180443
43lung vasculature development (GO:0060426)3.85591953
44fat-soluble vitamin biosynthetic process (GO:0042362)3.85264717
45metanephric nephron tubule development (GO:0072234)3.83867791
46metanephric tubule development (GO:0072170)3.83867791
47potassium ion homeostasis (GO:0055075)3.83586823
48excretion (GO:0007588)3.77733035
49parturition (GO:0007567)3.77367214
50drug transmembrane transport (GO:0006855)3.73911960
51ribosome assembly (GO:0042255)3.73649035
52sphingosine metabolic process (GO:0006670)3.72014912
53prostaglandin biosynthetic process (GO:0001516)3.71954094
54prostanoid biosynthetic process (GO:0046457)3.71954094
55keratinocyte development (GO:0003334)3.71726153
56regulation of chemokine secretion (GO:0090196)3.68887620
57outflow tract septum morphogenesis (GO:0003148)3.68777302
58diol metabolic process (GO:0034311)3.66458507
59regulation of mitochondrial translation (GO:0070129)3.65943085
60detection of bacterium (GO:0016045)3.64781510
61phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.61559228
62transcription from mitochondrial promoter (GO:0006390)3.60694327
63intestinal epithelial cell development (GO:0060576)3.55338689
64regulation of gene expression by genetic imprinting (GO:0006349)3.54537196
65positive regulation of Cdc42 GTPase activity (GO:0043089)3.54451636
66drug transport (GO:0015893)3.53326161
67metanephric nephron epithelium development (GO:0072243)3.50573417
68detection of other organism (GO:0098543)3.46513266
69negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.42800355
70negative regulation of metanephros development (GO:0072217)3.41756651
71calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.41741507
72surfactant homeostasis (GO:0043129)3.37253259
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.35782292
74negative regulation of transcription by competitive promoter binding (GO:0010944)3.34782599
75alditol phosphate metabolic process (GO:0052646)3.33451420
76oligosaccharide catabolic process (GO:0009313)3.33212969
77negative regulation of epidermal cell differentiation (GO:0045605)3.31732043
78regulation of dendritic cell antigen processing and presentation (GO:0002604)3.26290507
79translational initiation (GO:0006413)3.23042583
80acrosome reaction (GO:0007340)3.22137296
81cell differentiation involved in metanephros development (GO:0072202)3.21585929
82keratinization (GO:0031424)3.21510977
83eyelid development in camera-type eye (GO:0061029)3.21154739
84translational elongation (GO:0006414)3.20163957
85nucleotide transmembrane transport (GO:1901679)3.19724946
86GDP-mannose metabolic process (GO:0019673)3.17507361
87viral life cycle (GO:0019058)3.16901085
88mesonephros development (GO:0001823)3.16819158
89vitamin transport (GO:0051180)3.13912971
90glomerulus development (GO:0032835)3.13225477
91autophagic vacuole assembly (GO:0000045)3.10976892
92regulation of transforming growth factor beta1 production (GO:0032908)3.10532164
93glutathione metabolic process (GO:0006749)3.08328982
94import into cell (GO:0098657)3.07795395
95amino sugar catabolic process (GO:0046348)3.07556073
96DNA integration (GO:0015074)3.07402910
97positive regulation of epidermal cell differentiation (GO:0045606)3.07119723
98cellular protein complex disassembly (GO:0043624)3.05375068
99proteasome assembly (GO:0043248)3.04754766
100diaphragm development (GO:0060539)3.03802881
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.03514278
102phosphatidylcholine acyl-chain remodeling (GO:0036151)3.02278854
103one-carbon compound transport (GO:0019755)3.02207821
104bone remodeling (GO:0046849)3.01785129
105positive regulation of respiratory burst (GO:0060267)3.01746524
106viral protein processing (GO:0019082)3.00496820
107regulation of transforming growth factor beta2 production (GO:0032909)2.98810970
108collecting duct development (GO:0072044)2.95647663
109ribonucleoprotein complex biogenesis (GO:0022613)2.95265472
110regulation of double-strand break repair via homologous recombination (GO:0010569)2.94582000
111cotranslational protein targeting to membrane (GO:0006613)2.93985659
112positive regulation of antigen processing and presentation (GO:0002579)2.93741879
113protein targeting to ER (GO:0045047)2.93317469
114tooth mineralization (GO:0034505)2.93301954
115prostaglandin metabolic process (GO:0006693)2.93194190
116prostanoid metabolic process (GO:0006692)2.93194190
117sphingoid metabolic process (GO:0046519)2.90876434
118tRNA methylation (GO:0030488)2.86838355
119regulation of mesenchymal cell apoptotic process (GO:2001053)2.86073287
120positive regulation of cardiac muscle cell differentiation (GO:2000727)2.85070080
121rRNA methylation (GO:0031167)2.83347188
122desmosome organization (GO:0002934)2.83032091
123protein localization to endoplasmic reticulum (GO:0070972)2.82971898
124response to folic acid (GO:0051593)2.82502386
125formation of translation preinitiation complex (GO:0001731)2.82368799
126regulation of cardioblast differentiation (GO:0051890)2.82313060
127lymph vessel development (GO:0001945)2.82071592
128wound healing, spreading of epidermal cells (GO:0035313)2.81888362
129establishment of protein localization to endoplasmic reticulum (GO:0072599)2.80969893
130hypotonic response (GO:0006971)2.80774037
131very-low-density lipoprotein particle assembly (GO:0034379)2.80322973
132definitive hemopoiesis (GO:0060216)2.80246410
133establishment of skin barrier (GO:0061436)2.80191979
134sulfur compound transport (GO:0072348)2.80042929
135galactose metabolic process (GO:0006012)2.79314917
136establishment of planar polarity (GO:0001736)2.77080028
137establishment of tissue polarity (GO:0007164)2.77080028
138mammary gland development (GO:0030879)2.76272159
139multicellular organismal water homeostasis (GO:0050891)2.76014445
140auditory receptor cell differentiation (GO:0042491)2.75304835
141notochord development (GO:0030903)2.73720491
142regulation of keratinocyte differentiation (GO:0045616)2.73254374
143translation (GO:0006412)2.72812625
144hemidesmosome assembly (GO:0031581)2.71334143
145sulfate transmembrane transport (GO:1902358)2.71051900
146S-adenosylmethionine metabolic process (GO:0046500)2.70805612
147chemical homeostasis within a tissue (GO:0048875)2.70245673
148ribosome biogenesis (GO:0042254)2.70046149
149regulation of clathrin-mediated endocytosis (GO:2000369)2.69904032
150ribosomal large subunit biogenesis (GO:0042273)2.69723325
151metanephric mesenchyme development (GO:0072075)2.68592053
152cardiac right ventricle morphogenesis (GO:0003215)2.68581586
153regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.68533829
154metanephric epithelium development (GO:0072207)2.67951342
155epithelial cell maturation (GO:0002070)2.67459497
156regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.67210476
157NADH metabolic process (GO:0006734)2.64117843
158cofactor transport (GO:0051181)2.63353750
159regulation of hexokinase activity (GO:1903299)2.62714289
160regulation of glucokinase activity (GO:0033131)2.62714289
161negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.61923367
162negative regulation of kidney development (GO:0090185)2.61654720
163positive regulation of interleukin-8 secretion (GO:2000484)2.61336217
164mesenchymal cell differentiation involved in renal system development (GO:2001012)2.61217298
165mesenchymal cell differentiation involved in kidney development (GO:0072161)2.61217298
166sodium-independent organic anion transport (GO:0043252)2.60552965
167rRNA modification (GO:0000154)2.59158928
168nucleotide-sugar metabolic process (GO:0009225)2.57595937
169protein K6-linked ubiquitination (GO:0085020)2.56383026
170regulation of cellular extravasation (GO:0002691)2.55179489
171ear development (GO:0043583)2.55033404
172sulfate transport (GO:0008272)2.53994842
173keratan sulfate catabolic process (GO:0042340)2.51591247
174negative regulation of chemokine production (GO:0032682)2.50874859
175phosphate ion homeostasis (GO:0055062)2.50718945
176trivalent inorganic anion homeostasis (GO:0072506)2.50718945
177xenobiotic catabolic process (GO:0042178)2.50203079
178glucosamine-containing compound catabolic process (GO:1901072)2.50092262
179regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.47795958
180positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.47795958
181response to nitrosative stress (GO:0051409)10.5114790
182citrulline biosynthetic process (GO:0019240)10.5058325
183negative regulation of retinoic acid receptor signaling pathway (GO:0048387)10.0996083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human4.77811271
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.40220180
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.04218507
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.86576557
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.61227960
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.56017700
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.22435033
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.98762880
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94175478
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87662433
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.73293715
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.71672717
13FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.70955685
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.48608723
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41603084
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30483203
17AR_21909140_ChIP-Seq_LNCAP_Human2.30094475
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26603756
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.26164263
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22966748
21ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.12711526
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.04335121
23VDR_22108803_ChIP-Seq_LS180_Human2.03905536
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00185926
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.91859318
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89763901
27RACK7_27058665_Chip-Seq_MCF-7_Human1.86822387
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.83809928
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.83423963
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79295841
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.76824777
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76717436
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76402808
34GATA1_22025678_ChIP-Seq_K562_Human1.76391130
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.76347820
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.75636365
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75603190
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.75069991
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73112589
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69709617
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68617193
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67570021
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67570021
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67002086
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.66575429
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.66371503
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66010765
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.64828314
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63774923
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63134362
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.60352192
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59541950
53SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.57245708
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54486339
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52977418
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.52609100
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52383782
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52044273
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.51380839
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.50172131
61SOX2_20726797_ChIP-Seq_SW620_Human1.49872776
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45505334
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45505334
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45505334
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45095236
66RXR_22108803_ChIP-Seq_LS180_Human1.44088502
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.43083218
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43033077
69* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.41210644
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.41201212
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41128695
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40172207
73GATA6_25053715_ChIP-Seq_YYC3_Human1.38806932
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38566074
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38290930
76AHR_22903824_ChIP-Seq_MCF-7_Human1.36322481
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36159960
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.35521021
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.34012728
80* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32853974
81GATA4_25053715_ChIP-Seq_YYC3_Human1.32661792
82BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.32044191
83TP53_18474530_ChIP-ChIP_U2OS_Human1.31943126
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.31820009
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31209302
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.29337455
87PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.29296942
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28994608
89TTF2_22483619_ChIP-Seq_HELA_Human1.26459394
90SOX17_20123909_ChIP-Seq_XEN_Mouse1.25001232
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.24399536
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23896133
93CJUN_26792858_Chip-Seq_BT549_Human1.23852036
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23736108
95TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23176323
96NANOG_18692474_ChIP-Seq_MEFs_Mouse1.20818702
97* RUNX1_27514584_Chip-Seq_MCF-7_Human1.20588674
98GABP_19822575_ChIP-Seq_HepG2_Human1.18909015
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.17690954
100CTCF_21964334_Chip-Seq_Bcells_Human1.16217307
101TP63_22573176_ChIP-Seq_HFKS_Human1.15921930
102SA1_27219007_Chip-Seq_Bcells_Human1.15239736
103NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15025534
104LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14529116
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.14526678
106XRN2_22483619_ChIP-Seq_HELA_Human1.13722751
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.13610498
108TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.13272347
109CTCF_20526341_ChIP-Seq_ESCs_Human1.13099666
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12498942
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12482788
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11850758
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11342142
114ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11038701
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10973722
116NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10179001
117KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10102871
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09860463
119NANOG_16153702_ChIP-ChIP_HESCs_Human1.09539072
120CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08308609
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07683268
122BP1_19119308_ChIP-ChIP_Hs578T_Human1.06224200
123POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05827082
124GBX2_23144817_ChIP-Seq_PC3_Human1.05635820
125E2F7_22180533_ChIP-Seq_HELA_Human1.04621099
126ATF3_27146783_Chip-Seq_COLON_Human1.04147187
127TCF4_18268006_ChIP-ChIP_LS174T_Human1.04084314
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02742230
129BCOR_27268052_Chip-Seq_Bcells_Human1.02593528
130GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02336919
131PHF8_20622853_ChIP-Seq_HELA_Human1.01897036
132SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01375729
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01284578
134* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01045010
135ARNT_22903824_ChIP-Seq_MCF-7_Human1.00501980
136NANOG_16518401_ChIP-PET_MESCs_Mouse0.99131278
137KLF5_25053715_ChIP-Seq_YYC3_Human0.98671132
138SMC4_20622854_ChIP-Seq_HELA_Human0.98332338
139SRF_21415370_ChIP-Seq_HL-1_Mouse0.97441827
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97220692
141* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97150704
142SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96604703
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95999503
144* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95515720
145SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95073384
146ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95024403
147* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93976094
148KDM5A_27292631_Chip-Seq_BREAST_Human0.93773988
149ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93718427
150PHF8_20622854_ChIP-Seq_HELA_Human0.93501075
151ETV1_20927104_ChIP-Seq_GIST48_Human0.93074138
152DCP1A_22483619_ChIP-Seq_HELA_Human0.92939795
153CDX2_22108803_ChIP-Seq_LS180_Human0.92829031
154* CTCF_27219007_Chip-Seq_Bcells_Human0.92392915
155JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91625541
156TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91524147
157NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90865580
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90857850
159AR_21572438_ChIP-Seq_LNCaP_Human0.90608976
160POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89096210
161GATA3_24758297_ChIP-Seq_MCF-7_Human0.88797256
162TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88753069
163TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87785684
164ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86799440
165CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86046541
166RBPJ_21746931_ChIP-Seq_IB4_Human0.84889692
167TAF15_26573619_Chip-Seq_HEK293_Human0.84838668
168FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84564854
169NANOG_18692474_ChIP-Seq_MESCs_Mouse0.84360293
170CLOCK_20551151_ChIP-Seq_293T_Human0.82882548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology4.85534495
2MP0005377_hearing/vestibular/ear_phenot4.85534495
3MP0003941_abnormal_skin_development3.69428254
4MP0001542_abnormal_bone_strength3.32144786
5MP0004019_abnormal_vitamin_homeostasis3.26145136
6MP0004147_increased_porphyrin_level3.02957057
7* MP0001756_abnormal_urination2.99909482
8MP0004043_abnormal_pH_regulation2.88200322
9MP0003195_calcinosis2.76146059
10MP0005503_abnormal_tendon_morphology2.71086080
11MP0002876_abnormal_thyroid_physiology2.42088170
12MP0010234_abnormal_vibrissa_follicle2.30822919
13MP0005670_abnormal_white_adipose2.13977674
14MP0003315_abnormal_perineum_morphology2.06410903
15MP0008004_abnormal_stomach_pH2.04072019
16MP0000566_synostosis2.03330464
17MP0002254_reproductive_system_inflammat2.00602714
18MP0010368_abnormal_lymphatic_system1.99489564
19MP0001919_abnormal_reproductive_system1.91571427
20MP0005367_renal/urinary_system_phenotyp1.84076920
21MP0000516_abnormal_urinary_system1.84076920
22MP0003718_maternal_effect1.82708843
23MP0008872_abnormal_physiological_respon1.72204606
24MP0003693_abnormal_embryo_hatching1.71884926
25MP0009643_abnormal_urine_homeostasis1.69720942
26MP0008260_abnormal_autophagy1.68768668
27MP0005275_abnormal_skin_tensile1.65732684
28MP0004484_altered_response_of1.62952922
29MP0002796_impaired_skin_barrier1.61734502
30MP0005084_abnormal_gallbladder_morpholo1.61292760
31MP0002098_abnormal_vibrissa_morphology1.56013473
32MP0000762_abnormal_tongue_morphology1.54753063
33MP0003566_abnormal_cell_adhesion1.53499738
34MP0002108_abnormal_muscle_morphology1.50930515
35MP0003786_premature_aging1.47185634
36MP0005389_reproductive_system_phenotype1.46445860
37MP0004185_abnormal_adipocyte_glucose1.42984221
38MP0004272_abnormal_basement_membrane1.40891289
39MP0003186_abnormal_redox_activity1.40674563
40* MP0002136_abnormal_kidney_physiology1.40397023
41MP0002132_abnormal_respiratory_system1.35743744
42MP0004957_abnormal_blastocyst_morpholog1.35608031
43MP0001905_abnormal_dopamine_level1.33917690
44MP0000383_abnormal_hair_follicle1.33756565
45* MP0001765_abnormal_ion_homeostasis1.29266373
46MP0003879_abnormal_hair_cell1.27560155
47MP0009333_abnormal_splenocyte_physiolog1.27168650
48MP0005451_abnormal_body_composition1.26891743
49MP0001764_abnormal_homeostasis1.26876397
50MP0000534_abnormal_ureter_morphology1.25992780
51MP0004264_abnormal_extraembryonic_tissu1.23030222
52MP0005508_abnormal_skeleton_morphology1.22523364
53MP0002115_abnormal_skeleton_extremities1.21596278
54MP0005501_abnormal_skin_physiology1.21511704
55MP0000647_abnormal_sebaceous_gland1.21204158
56MP0000538_abnormal_urinary_bladder1.19572159
57MP0001270_distended_abdomen1.17619371
58MP0010386_abnormal_urinary_bladder1.17458547
59MP0008007_abnormal_cellular_replicative1.17170027
60MP0000678_abnormal_parathyroid_gland1.15949858
61MP0005332_abnormal_amino_acid1.13166199
62MP0005394_taste/olfaction_phenotype1.11734400
63MP0005499_abnormal_olfactory_system1.11734400
64MP0003111_abnormal_nucleus_morphology1.10854809
65MP0009250_abnormal_appendicular_skeleto1.09866806
66MP0003950_abnormal_plasma_membrane1.09137300
67MP0005666_abnormal_adipose_tissue1.08393322
68MP0004782_abnormal_surfactant_physiolog1.07395650
69MP0010352_gastrointestinal_tract_polyps1.07097212
70MP0008789_abnormal_olfactory_epithelium1.06185462
71MP0003136_yellow_coat_color1.05437209
72MP0009053_abnormal_anal_canal1.03192946
73MP0003943_abnormal_hepatobiliary_system1.02625762
74MP0002138_abnormal_hepatobiliary_system1.02120451
75MP0005395_other_phenotype1.01988997
76MP0000163_abnormal_cartilage_morphology1.00089247
77MP0009278_abnormal_bone_marrow0.99985141
78MP0000627_abnormal_mammary_gland0.99611884
79MP0003191_abnormal_cellular_cholesterol0.98157222
80MP0003806_abnormal_nucleotide_metabolis0.95716880
81MP0003453_abnormal_keratinocyte_physiol0.95073213
82MP0003936_abnormal_reproductive_system0.94573783
83MP0001879_abnormal_lymphatic_vessel0.93869488
84MP0004381_abnormal_hair_follicle0.93621379
85MP0000613_abnormal_salivary_gland0.93540830
86MP0002896_abnormal_bone_mineralization0.93398732
87MP0002160_abnormal_reproductive_system0.90982130
88MP0006138_congestive_heart_failure0.90879834
89* MP0005636_abnormal_mineral_homeostasis0.88626060
90MP0005646_abnormal_pituitary_gland0.84751986
91MP0009379_abnormal_foot_pigmentation0.84207902
92MP0002113_abnormal_skeleton_development0.83978163
93MP0001188_hyperpigmentation0.83666758
94MP0005390_skeleton_phenotype0.83298457
95MP0001119_abnormal_female_reproductive0.81966629
96MP0001958_emphysema0.81681382
97MP0008875_abnormal_xenobiotic_pharmacok0.81206933
98MP0001664_abnormal_digestion0.80904850
99MP0004134_abnormal_chest_morphology0.80785012
100MP0003938_abnormal_ear_development0.80036044
101MP0005058_abnormal_lysosome_morphology0.79970024
102MP0000681_abnormal_thyroid_gland0.79728192
103MP0000026_abnormal_inner_ear0.79559893
104MP0002060_abnormal_skin_morphology0.79454418
105MP0002998_abnormal_bone_remodeling0.79392386
106MP0010678_abnormal_skin_adnexa0.78450961
107MP0003252_abnormal_bile_duct0.77804141
108MP0008058_abnormal_DNA_repair0.77036177
109MP0009780_abnormal_chondrocyte_physiolo0.76817666
110MP0010771_integument_phenotype0.75499588
111MP0002735_abnormal_chemical_nociception0.74647791
112MP0001963_abnormal_hearing_physiology0.74282694
113MP0002102_abnormal_ear_morphology0.73523144
114MP0003795_abnormal_bone_structure0.72032320
115MP0006035_abnormal_mitochondrial_morpho0.71933873
116MP0002127_abnormal_cardiovascular_syste0.71497030
117MP0000465_gastrointestinal_hemorrhage0.71325064
118MP0001672_abnormal_embryogenesis/_devel0.70788674
119MP0005380_embryogenesis_phenotype0.70788674
120MP0001216_abnormal_epidermal_layer0.70124511
121MP0000377_abnormal_hair_follicle0.69520564
122MP0002396_abnormal_hematopoietic_system0.68736134
123MP0003724_increased_susceptibility_to0.68145794
124MP0003984_embryonic_growth_retardation0.66066783
125MP0002088_abnormal_embryonic_growth/wei0.65263825
126MP0000470_abnormal_stomach_morphology0.64028754
127MP0005365_abnormal_bile_salt0.62975848
128MP0003183_abnormal_peptide_metabolism0.61577892
129MP0005423_abnormal_somatic_nervous0.60453298
130MP0003646_muscle_fatigue0.59803998
131MP0006036_abnormal_mitochondrial_physio0.59245897
132MP0002086_abnormal_extraembryonic_tissu0.58545930
133MP0001697_abnormal_embryo_size0.56771092
134MP0004885_abnormal_endolymph0.56729031
135MP0001730_embryonic_growth_arrest0.56700891
136MP0005375_adipose_tissue_phenotype0.53436259
137MP0001986_abnormal_taste_sensitivity0.53141649
138MP0001485_abnormal_pinna_reflex0.50877595
139MP0002085_abnormal_embryonic_tissue0.49841615
140MP0000358_abnormal_cell_content/0.49168579
141MP0002084_abnormal_developmental_patter0.47248620
142MP0008995_early_reproductive_senescence0.47056996
143MP0001346_abnormal_lacrimal_gland0.46879235
144MP0002135_abnormal_kidney_morphology0.46395777
145MP0000350_abnormal_cell_proliferation0.45932308
146MP0002080_prenatal_lethality0.44435550
147MP0002736_abnormal_nociception_after0.44417071
148MP0009672_abnormal_birth_weight0.44220906
149MP0003077_abnormal_cell_cycle0.43904875
150MP0002210_abnormal_sex_determination0.41926642
151MP0003567_abnormal_fetal_cardiomyocyte0.38167380
152MP0000467_abnormal_esophagus_morphology0.37475846
153MP0000367_abnormal_coat/_hair0.37035435
154MP0000477_abnormal_intestine_morphology0.36449778
155MP0003890_abnormal_embryonic-extraembry0.35985444
156MP0002163_abnormal_gland_morphology0.33554298

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)5.54550346
2Hyperactive renin-angiotensin system (HP:0000841)4.99785332
3Hypomagnesemia (HP:0002917)4.53242757
4Tetany (HP:0001281)4.49108046
5Abnormality of chloride homeostasis (HP:0011422)4.38192940
6Hypokalemic alkalosis (HP:0001949)4.23766681
7Abnormal tarsal ossification (HP:0008369)4.22699373
8Lip pit (HP:0100267)4.14949399
9Eczematoid dermatitis (HP:0000976)4.03257892
10Abnormality of magnesium homeostasis (HP:0004921)4.00591563
11Polyuria (HP:0000103)3.84894253
12Congenital, generalized hypertrichosis (HP:0004540)3.80662284
13Renal salt wasting (HP:0000127)3.79330879
14Hyperaldosteronism (HP:0000859)3.69282648
15Increased circulating renin level (HP:0000848)3.66806127
16Abnormal foot bone ossification (HP:0010675)3.64151803
17Ileus (HP:0002595)3.56711368
18Seborrheic dermatitis (HP:0001051)3.55850885
19Submucous cleft hard palate (HP:0000176)3.42403355
20Abnormal urine output (HP:0012590)3.40412917
21Distal lower limb muscle weakness (HP:0009053)3.32548039
22Abnormality of renal excretion (HP:0011036)3.28530237
23Cerebral palsy (HP:0100021)3.27066087
24Irregular epiphyses (HP:0010582)3.24582439
25Parakeratosis (HP:0001036)3.19834560
26Facial diplegia (HP:0001349)3.19217861
27Proximal tubulopathy (HP:0000114)3.17963841
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.16121926
29Abnormality of carpal bone ossification (HP:0006257)3.00044287
30Stillbirth (HP:0003826)2.98198187
31Gout (HP:0001997)2.93606246
32Abnormality of the salivary glands (HP:0010286)2.93256038
33Dehydration (HP:0001944)2.88977439
34Long foot (HP:0001833)2.88396300
35Abnormal drinking behavior (HP:0030082)2.88050244
36Polydipsia (HP:0001959)2.88050244
37Congenital ichthyosiform erythroderma (HP:0007431)2.87272103
38Abnormality of the distal phalanges of the toes (HP:0010182)2.84888892
39Abnormality of renin-angiotensin system (HP:0000847)2.79449554
40Adrenal overactivity (HP:0002717)2.79014941
41Papilledema (HP:0001085)2.78120021
42Flat acetabular roof (HP:0003180)2.70802097
43Growth hormone excess (HP:0000845)2.63354111
44Microvesicular hepatic steatosis (HP:0001414)2.61395929
45Alkalosis (HP:0001948)2.59151670
46Onycholysis (HP:0001806)2.57079208
47Amelogenesis imperfecta (HP:0000705)2.53182646
48Short nail (HP:0001799)2.51043103
49Concave nail (HP:0001598)2.50084855
50Neonatal short-limb short stature (HP:0008921)2.49766833
51Hypokalemia (HP:0002900)2.46744925
52Abnormality of urine glucose concentration (HP:0011016)2.46117218
53Glycosuria (HP:0003076)2.46117218
54Abnormality of permanent molar morphology (HP:0011071)2.45843334
55Abnormality of the dental root (HP:0006486)2.45843334
56Taurodontia (HP:0000679)2.45843334
57Microretrognathia (HP:0000308)2.45057070
58Premature rupture of membranes (HP:0001788)2.41440302
59Hypoplasia of the uterus (HP:0000013)2.35629795
60Glucose intolerance (HP:0000833)2.35174004
61Epiphyseal dysplasia (HP:0002656)2.35143401
62Abnormality of the aortic arch (HP:0012303)2.34555131
63Cervical subluxation (HP:0003308)2.34264997
64Insulin-resistant diabetes mellitus (HP:0000831)2.33118523
65Myopathic facies (HP:0002058)2.32663805
66Vitreoretinal degeneration (HP:0000655)2.32129263
67Abnormal pancreas size (HP:0012094)2.31899299
68Generalized aminoaciduria (HP:0002909)2.27947306
69Flat capital femoral epiphysis (HP:0003370)2.27602027
70Natal tooth (HP:0000695)2.26743904
71Anhidrosis (HP:0000970)2.25125015
72Petechiae (HP:0000967)2.24563727
73Delayed epiphyseal ossification (HP:0002663)2.24360037
74Abnormality of molar (HP:0011077)2.23830734
75Abnormality of molar morphology (HP:0011070)2.23830734
76Cupped ribs (HP:0000887)2.22667419
77Increased purine levels (HP:0004368)2.21059164
78Hyperuricemia (HP:0002149)2.21059164
79Nephrocalcinosis (HP:0000121)2.20907066
80Hyperkalemia (HP:0002153)2.16232430
81Metaphyseal irregularity (HP:0003025)2.16152821
82Aplasia/hypoplasia of the uterus (HP:0008684)2.15904754
83Abnormality of the dental pulp (HP:0006479)2.15063297
84Bilateral sensorineural hearing impairment (HP:0008619)2.14461975
85Redundant skin (HP:0001582)2.12818133
86Reduced subcutaneous adipose tissue (HP:0003758)2.12499565
87Chronic bronchitis (HP:0004469)2.11731758
88Ureteral duplication (HP:0000073)2.11070773
89Carpal bone hypoplasia (HP:0001498)2.11028358
90Advanced eruption of teeth (HP:0006288)2.10314513
91Abnormality of purine metabolism (HP:0004352)2.09664265
92Abnormality of monocarboxylic acid metabolism (HP:0010996)2.08744930
93Hypercalciuria (HP:0002150)2.05575217
94Aplasia of the musculature (HP:0100854)2.04505083
95Osteomalacia (HP:0002749)2.04026910
96Palmoplantar hyperkeratosis (HP:0000972)2.01845030
97Double outlet right ventricle (HP:0001719)2.00508617
98Congenital malformation of the right heart (HP:0011723)2.00508617
99Abnormal ossification of hand bones (HP:0005921)1.99857197
100Abnormal hand bone ossification (HP:0010660)1.98494163
101Rough bone trabeculation (HP:0100670)1.97660051
102Decreased circulating renin level (HP:0003351)1.97378059
103Hyperglycemia (HP:0003074)1.96702440
104Nasolacrimal duct obstruction (HP:0000579)1.96174917
105Septate vagina (HP:0001153)1.93400235
106Metaphyseal cupping (HP:0003021)1.93018600
107Abnormal trabecular bone morphology (HP:0100671)1.92994598
108Renal tubular acidosis (HP:0001947)1.92632660
109Abnormal vertebral ossification (HP:0100569)1.92025935
110Focal segmental glomerulosclerosis (HP:0000097)1.90676981
111Hyperglycinuria (HP:0003108)1.88932956
112Hyperphosphaturia (HP:0003109)1.88929077
113Choanal stenosis (HP:0000452)1.88185340
114Palmar hyperkeratosis (HP:0010765)1.87405648
115Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87365494
116Bicornuate uterus (HP:0000813)1.85992488
117Abnormality of potassium homeostasis (HP:0011042)1.84372779
118Upper limb muscle weakness (HP:0003484)1.84251318
119Alveolar cell carcinoma (HP:0006519)1.83208990
120Birth length less than 3rd percentile (HP:0003561)1.82909835
121Skin pits (HP:0100276)1.82222367
122Abnormality of the costochondral junction (HP:0000919)1.82112023
123Prolonged neonatal jaundice (HP:0006579)1.81330395
124Long clavicles (HP:0000890)1.81194973
125Hip contracture (HP:0003273)1.80639715
126Absent hand (HP:0004050)1.79541068
127Erythroderma (HP:0001019)1.78793285
128Abnormality of sodium homeostasis (HP:0010931)1.78173279
129Shawl scrotum (HP:0000049)1.76960818
130Stenosis of the external auditory canal (HP:0000402)1.76333533
131Genu varum (HP:0002970)1.76094148
132Conical tooth (HP:0000698)1.76041824
133Severe Myopia (HP:0011003)1.74438917
134Renal cortical cysts (HP:0000803)1.73978605
135Progressive visual loss (HP:0000529)1.73516042
136Patent foramen ovale (HP:0001655)1.72742995
137Cerebral hypomyelination (HP:0006808)1.72702195
138Alopecia of scalp (HP:0002293)1.72172058
139Hyponatremia (HP:0002902)1.71892211
140Curly hair (HP:0002212)1.71616430
141Abnormality of nucleobase metabolism (HP:0010932)1.71254023
142Sparse eyelashes (HP:0000653)1.69320794
143Abnormal glucose tolerance (HP:0001952)1.68786517
144Autoamputation (HP:0001218)1.68019828
145Multiple enchondromatosis (HP:0005701)1.67843514
146Abnormality of the fetal cardiovascular system (HP:0010948)1.67122730
147Abnormal umbilical cord blood vessels (HP:0011403)1.67122730
148Single umbilical artery (HP:0001195)1.67122730
149Increased density of long bones (HP:0006392)1.67038026
150Spinal cord compression (HP:0002176)1.67029733
151Pancreatic islet-cell hyperplasia (HP:0004510)1.66650222
152Breast hypoplasia (HP:0003187)1.66354056
153Rickets (HP:0002748)1.66011085
154Abnormality of the lacrimal duct (HP:0011481)1.65524280
155Absent eyebrow (HP:0002223)1.65217602
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.64764154
157Osteolytic defects of the hand bones (HP:0009699)1.64764154
158Abnormality of fatty-acid metabolism (HP:0004359)1.64370758
159Abnormality of cells of the erythroid lineage (HP:0012130)1.64137380
160Adrenal hypoplasia (HP:0000835)1.63562009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.24828468
2EPHA25.30470944
3PBK4.29702465
4AKT33.79278280
5STK393.63061106
6INSRR3.58904452
7TSSK63.15041352
8NME23.05910768
9MYLK2.98212888
10STK38L2.83393785
11WNK32.79784736
12CASK2.73773894
13GRK12.48477672
14ZAK2.44304525
15GRK52.10672782
16PINK12.05884505
17MAP3K31.98480372
18SGK21.87245625
19OXSR11.81118988
20FRK1.73947408
21MATK1.73797329
22SGK2231.69961866
23SGK4941.69961866
24PIM21.66096328
25MET1.63307958
26STK241.60772758
27TYRO31.53677485
28MST41.49150635
29TRPM71.46731168
30NUAK11.38960233
31LATS11.32093064
32SGK31.30007568
33EPHB21.17243868
34NLK1.16506078
35LMTK21.13776541
36FGR1.12330800
37SMG11.11460846
38PLK31.11385601
39MST1R1.11333739
40MAP3K121.09967065
41CCNB11.08587898
42WNK41.06440336
43LRRK21.06099884
44BUB11.03883252
45NME11.03787984
46TEC1.02449099
47PHKG21.01994313
48PHKG11.01994313
49PDK21.01545193
50PRKCI0.99080848
51MAP2K20.98204167
52TRIM280.97826049
53PRKCE0.96371673
54MAP3K140.95793597
55EIF2AK20.94438777
56ADRBK20.94158566
57BRAF0.88760161
58NEK60.87518997
59FER0.83861815
60PDK30.82194278
61PDK40.82194278
62WEE10.81766658
63ERBB30.77165079
64PLK20.75921017
65PRPF4B0.75637913
66TESK20.75594372
67EIF2AK10.72761816
68MAP3K20.72176006
69STK40.71891318
70ILK0.70219217
71MKNK20.69769375
72EIF2AK30.68545997
73RPS6KB20.67650710
74MAP3K70.67317057
75BMX0.60872692
76YES10.58276910
77AKT20.57804872
78PLK40.57737994
79RIPK10.56567867
80PRKCG0.56203298
81TAOK20.56096565
82STK100.55911723
83STK160.55235808
84VRK10.54061946
85MAP2K10.53241591
86NEK20.53201711
87TTK0.52963116
88ABL20.52419355
89DDR20.51785652
90IRAK30.51752785
91SRPK10.51066791
92PIM10.50809086
93WNK10.49936161
94MAP2K70.49043651
95MAP3K130.48624204
96DAPK30.48360374
97MKNK10.48206725
98RPS6KB10.47214159
99STK380.46424611
100CDK190.45699764
101CDK90.45135489
102TESK10.43442530
103MAPK70.41479853
104PAK40.40690491
105MAP3K80.39275200
106FGFR10.35965070
107CDK40.35242169
108ICK0.34475538
109TAOK10.34248059
110CAMK1D0.31983134
111PLK10.30357674
112PIK3CG0.30013122
113GSK3A0.29914804
114BCR0.29787200
115PRKAA10.29471507
116SGK10.29295039
117TXK0.29278785
118MAPKAPK20.28666548
119MAP2K60.27582657
120CSNK2A10.26188439
121CDK70.25750635
122NEK10.25562614
123CHEK10.25541540
124PRKCD0.25125988
125DMPK0.24565740
126AURKB0.24145893
127AURKA0.24131597
128PRKCZ0.24129877
129BRSK10.24073558
130BMPR20.23257416
131EPHA30.23157160
132CDK80.23064383
133GRK70.22887553
134LATS20.22750823
135RPS6KA10.22600196
136CHEK20.22398257
137CAMK2G0.22363768
138ROCK20.22005794
139STK30.20558219
140PRKD20.19872517
141PAK10.19503652
142ARAF0.19176732
143PTK20.18884819
144CDK30.18773476
145VRK20.18692714
146PRKCQ0.18659201
147MUSK0.18341816
148MTOR0.17881807
149ROCK10.17742401
150BMPR1B0.17375840
151MAP2K30.17029812
152CSNK1A10.16810819
153CDK120.16793486
154MARK20.16581516
155MELK0.15618670

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.53924042
2Pentose and glucuronate interconversions_Homo sapiens_hsa000403.12662629
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09915613
4Proteasome_Homo sapiens_hsa030503.04832546
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.84577474
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.61488271
7Collecting duct acid secretion_Homo sapiens_hsa049662.60584224
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.58815859
9Linoleic acid metabolism_Homo sapiens_hsa005912.56868305
10Rheumatoid arthritis_Homo sapiens_hsa053232.49183185
11Vitamin B6 metabolism_Homo sapiens_hsa007502.46743733
12Mineral absorption_Homo sapiens_hsa049782.44058785
13Vitamin digestion and absorption_Homo sapiens_hsa049772.21590864
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.02412251
15Fructose and mannose metabolism_Homo sapiens_hsa000512.01387547
16Arachidonic acid metabolism_Homo sapiens_hsa005901.98678991
17Bladder cancer_Homo sapiens_hsa052191.90877509
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.90732669
19Sulfur metabolism_Homo sapiens_hsa009201.86418255
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.84899205
21Glutathione metabolism_Homo sapiens_hsa004801.79032657
22Ether lipid metabolism_Homo sapiens_hsa005651.76757698
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75693356
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73041948
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72170776
26Fat digestion and absorption_Homo sapiens_hsa049751.70025861
27RNA polymerase_Homo sapiens_hsa030201.66042948
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59833416
29Sulfur relay system_Homo sapiens_hsa041221.57352160
30Sphingolipid metabolism_Homo sapiens_hsa006001.53484210
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52273834
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.46109300
33beta-Alanine metabolism_Homo sapiens_hsa004101.45612221
34Protein digestion and absorption_Homo sapiens_hsa049741.43568050
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36503763
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32389985
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.31836328
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31703014
39ECM-receptor interaction_Homo sapiens_hsa045121.28020522
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25894254
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.24348877
42Chemical carcinogenesis_Homo sapiens_hsa052041.20472610
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.20053736
44mRNA surveillance pathway_Homo sapiens_hsa030151.19434663
45Starch and sucrose metabolism_Homo sapiens_hsa005001.19189800
46* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16200052
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.09834041
48Tight junction_Homo sapiens_hsa045301.09640099
49Vibrio cholerae infection_Homo sapiens_hsa051101.07491900
50Renin-angiotensin system_Homo sapiens_hsa046141.06424985
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04926516
52Basal transcription factors_Homo sapiens_hsa030221.03286454
53Parkinsons disease_Homo sapiens_hsa050121.02820788
54Adherens junction_Homo sapiens_hsa045201.00222606
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99418209
56Galactose metabolism_Homo sapiens_hsa000520.98803225
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96320044
58Folate biosynthesis_Homo sapiens_hsa007900.95552441
59Pyrimidine metabolism_Homo sapiens_hsa002400.95376406
60Retinol metabolism_Homo sapiens_hsa008300.94163885
61Purine metabolism_Homo sapiens_hsa002300.94140039
62Huntingtons disease_Homo sapiens_hsa050160.92792922
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91637880
64Fanconi anemia pathway_Homo sapiens_hsa034600.90684640
65Regulation of autophagy_Homo sapiens_hsa041400.85472645
66Butanoate metabolism_Homo sapiens_hsa006500.85349119
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85029387
68Thyroid cancer_Homo sapiens_hsa052160.79378411
69Spliceosome_Homo sapiens_hsa030400.78855500
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75443973
71Base excision repair_Homo sapiens_hsa034100.74154835
72Inositol phosphate metabolism_Homo sapiens_hsa005620.72907289
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.72801056
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71871917
75Other glycan degradation_Homo sapiens_hsa005110.69476587
76Fatty acid elongation_Homo sapiens_hsa000620.68405027
77Legionellosis_Homo sapiens_hsa051340.68379182
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68361200
79Peroxisome_Homo sapiens_hsa041460.67928657
80Phenylalanine metabolism_Homo sapiens_hsa003600.66496267
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.63887132
82Gastric acid secretion_Homo sapiens_hsa049710.62531657
83Propanoate metabolism_Homo sapiens_hsa006400.61746975
84HIF-1 signaling pathway_Homo sapiens_hsa040660.61092214
85RNA transport_Homo sapiens_hsa030130.60862670
86Synaptic vesicle cycle_Homo sapiens_hsa047210.60425429
87Endocytosis_Homo sapiens_hsa041440.59071860
88Cardiac muscle contraction_Homo sapiens_hsa042600.58643810
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58522668
90Ovarian steroidogenesis_Homo sapiens_hsa049130.58264367
91ABC transporters_Homo sapiens_hsa020100.57981267
92Hippo signaling pathway_Homo sapiens_hsa043900.56552995
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55492408
94Thyroid hormone synthesis_Homo sapiens_hsa049180.54268297
95Hepatitis C_Homo sapiens_hsa051600.53673726
96Cell cycle_Homo sapiens_hsa041100.52745271
97Arginine and proline metabolism_Homo sapiens_hsa003300.52177595
98Autoimmune thyroid disease_Homo sapiens_hsa053200.51656993
99RNA degradation_Homo sapiens_hsa030180.51487270
100Bile secretion_Homo sapiens_hsa049760.50636395
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49809143
102Metabolic pathways_Homo sapiens_hsa011000.48513695
103Selenocompound metabolism_Homo sapiens_hsa004500.47673505
104Oxidative phosphorylation_Homo sapiens_hsa001900.46849051
105Graft-versus-host disease_Homo sapiens_hsa053320.46833765
106Hedgehog signaling pathway_Homo sapiens_hsa043400.46171538
107Circadian rhythm_Homo sapiens_hsa047100.45096007
108Phagosome_Homo sapiens_hsa041450.44939485
109TGF-beta signaling pathway_Homo sapiens_hsa043500.44045646
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42765213
111Fatty acid biosynthesis_Homo sapiens_hsa000610.42179456
112Histidine metabolism_Homo sapiens_hsa003400.40282845
113Pancreatic secretion_Homo sapiens_hsa049720.40248644
114Focal adhesion_Homo sapiens_hsa045100.39831794
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39319532
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37768404
117DNA replication_Homo sapiens_hsa030300.37675665
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36587370
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.34489999
120Carbon metabolism_Homo sapiens_hsa012000.34116578
121One carbon pool by folate_Homo sapiens_hsa006700.33579191
122Basal cell carcinoma_Homo sapiens_hsa052170.33248954
123Pentose phosphate pathway_Homo sapiens_hsa000300.33044147
124p53 signaling pathway_Homo sapiens_hsa041150.32936580
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32534991
126Epstein-Barr virus infection_Homo sapiens_hsa051690.31974718
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31713658
128Arginine biosynthesis_Homo sapiens_hsa002200.31597555
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30835006
130Homologous recombination_Homo sapiens_hsa034400.30758243
131PPAR signaling pathway_Homo sapiens_hsa033200.30611834
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30269252
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29081938
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25432146
135Lysosome_Homo sapiens_hsa041420.25142732
136Steroid biosynthesis_Homo sapiens_hsa001000.23324510
137Biosynthesis of amino acids_Homo sapiens_hsa012300.21288804
138Oocyte meiosis_Homo sapiens_hsa041140.20856961

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