FXYD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.01535125
2positive regulation of gamma-delta T cell activation (GO:0046645)4.71891864
3neutrophil activation involved in immune response (GO:0002283)4.65415058
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.65249904
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.65249904
6immunoglobulin mediated immune response (GO:0016064)4.52992284
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.41349706
8regulation of B cell receptor signaling pathway (GO:0050855)4.33432456
9leukocyte aggregation (GO:0070486)4.30224932
10antigen processing and presentation of endogenous antigen (GO:0019883)4.26103396
11modulation by symbiont of host immune response (GO:0052553)4.24033690
12positive regulation by symbiont of host defense response (GO:0052509)4.24033690
13modulation by symbiont of host defense response (GO:0052031)4.24033690
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.24033690
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.24033690
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.24033690
17mast cell activation (GO:0045576)4.04755844
18respiratory burst (GO:0045730)3.87637428
19T cell migration (GO:0072678)3.82979054
20Arp2/3 complex-mediated actin nucleation (GO:0034314)3.80546317
21response to peptidoglycan (GO:0032494)3.74772290
22defense response to protozoan (GO:0042832)3.68712162
23positive regulation of interferon-alpha production (GO:0032727)3.67420816
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.66022479
25B cell mediated immunity (GO:0019724)3.62011251
26cellular response to type I interferon (GO:0071357)3.58707082
27type I interferon signaling pathway (GO:0060337)3.58707082
28response to type I interferon (GO:0034340)3.57446174
29antigen processing and presentation via MHC class Ib (GO:0002475)3.56506951
30regulation of interferon-alpha production (GO:0032647)3.53232266
31response to protozoan (GO:0001562)3.52662776
32response to interferon-beta (GO:0035456)3.50827027
33myeloid dendritic cell activation (GO:0001773)3.50780338
34regulation of interferon-beta biosynthetic process (GO:0045357)3.49870417
35interferon-gamma production (GO:0032609)3.43659566
36regulation of B cell differentiation (GO:0045577)3.40761598
37myeloid cell activation involved in immune response (GO:0002275)3.39016360
38cellular extravasation (GO:0045123)3.34004232
39myeloid dendritic cell differentiation (GO:0043011)3.32035057
40neutrophil activation (GO:0042119)3.31680744
41positive regulation of B cell differentiation (GO:0045579)3.30108123
42interferon-gamma-mediated signaling pathway (GO:0060333)3.30016470
43regulation of T cell mediated cytotoxicity (GO:0001914)3.25855780
44granulocyte activation (GO:0036230)3.24023393
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.23676604
46regulation of gamma-delta T cell differentiation (GO:0045586)3.23505510
47regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23101330
48negative regulation of cell killing (GO:0031342)3.21016663
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.21016663
50regulation of gamma-delta T cell activation (GO:0046643)3.19565225
51cellular response to interferon-beta (GO:0035458)3.18774092
52positive regulation of T cell mediated cytotoxicity (GO:0001916)3.18516701
53regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.16671152
54regulation of regulatory T cell differentiation (GO:0045589)3.16161745
55positive regulation of macrophage differentiation (GO:0045651)3.14886240
56production of molecular mediator involved in inflammatory response (GO:0002532)3.13823061
57negative thymic T cell selection (GO:0045060)3.12971668
58macrophage activation involved in immune response (GO:0002281)3.11873872
59autophagic vacuole fusion (GO:0000046)3.11706333
60positive regulation of mast cell activation (GO:0033005)3.10773660
61negative T cell selection (GO:0043383)3.09442515
62response to interferon-alpha (GO:0035455)3.09306401
63cellular response to zinc ion (GO:0071294)3.08434514
64negative regulation of T cell mediated immunity (GO:0002710)3.07775062
65negative regulation of erythrocyte differentiation (GO:0045647)3.06063317
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06058563
67negative regulation of interleukin-12 production (GO:0032695)3.03571885
68positive regulation of B cell mediated immunity (GO:0002714)3.00213089
69positive regulation of immunoglobulin mediated immune response (GO:0002891)3.00213089
70NIK/NF-kappaB signaling (GO:0038061)2.99717998
71thymic T cell selection (GO:0045061)2.99003179
72positive regulation of isotype switching (GO:0045830)2.98652200
73positive regulation of interleukin-17 production (GO:0032740)2.98188600
74regulation of T cell receptor signaling pathway (GO:0050856)2.98041876
75positive regulation of antigen processing and presentation (GO:0002579)2.97258176
76sequestering of actin monomers (GO:0042989)2.94691730
77positive regulation of granulocyte differentiation (GO:0030854)2.94154641
78negative regulation of myeloid cell apoptotic process (GO:0033033)2.94116182
79actin nucleation (GO:0045010)2.93975353
80positive T cell selection (GO:0043368)2.93500214
81lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93123673
82T cell selection (GO:0045058)2.91995483
83B cell receptor signaling pathway (GO:0050853)2.91068231
84leukocyte cell-cell adhesion (GO:0007159)2.90383236
85tolerance induction (GO:0002507)2.89970557
86cellular response to interleukin-15 (GO:0071350)2.89968168
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89319900
88positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88836373
89ribosomal small subunit assembly (GO:0000028)2.87977480
90positive thymic T cell selection (GO:0045059)2.87531165
91negative regulation of phagocytosis (GO:0050765)2.87326138
92regulation of natural killer cell mediated immunity (GO:0002715)2.87092845
93regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.87092845
94response to interleukin-15 (GO:0070672)2.87075670
95mast cell activation involved in immune response (GO:0002279)2.86829787
96mast cell degranulation (GO:0043303)2.86829787
97regulation of mast cell activation (GO:0033003)2.86669057
98leukocyte degranulation (GO:0043299)2.85847283
99negative regulation of lymphocyte mediated immunity (GO:0002707)2.84850277
100detection of bacterium (GO:0016045)2.83625563
101myeloid leukocyte activation (GO:0002274)2.83174527
102response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83146204
103response to host immune response (GO:0052572)2.83146204
104regulation of leukocyte mediated cytotoxicity (GO:0001910)2.81199014
105positive regulation of chemokine biosynthetic process (GO:0045080)2.81111494
106regulation of T cell tolerance induction (GO:0002664)2.80639838
107positive regulation of alpha-beta T cell proliferation (GO:0046641)2.80110072
108regulation of hypersensitivity (GO:0002883)2.78954650
109negative regulation of leukocyte mediated immunity (GO:0002704)2.78876817
110regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.78667301
111response to muramyl dipeptide (GO:0032495)2.77432600
112positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76499002
113regulation of mast cell activation involved in immune response (GO:0033006)2.76462458
114regulation of chemokine biosynthetic process (GO:0045073)2.76095966
115regulation of mast cell degranulation (GO:0043304)2.75602042
116positive regulation of interferon-beta production (GO:0032728)2.74213417
117regulation of alpha-beta T cell proliferation (GO:0046640)2.73587840
118detection of other organism (GO:0098543)2.72862041
119negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.72649603
120negative regulation of innate immune response (GO:0045824)2.72075081
121negative regulation of T cell receptor signaling pathway (GO:0050860)2.71646505
122germinal center formation (GO:0002467)2.70679951
123regulation of antigen processing and presentation (GO:0002577)2.70496399
124dendritic cell differentiation (GO:0097028)2.69773609
125positive regulation of mast cell degranulation (GO:0043306)2.69516989
126positive regulation of mast cell activation involved in immune response (GO:0033008)2.69516989
127regulation of dendritic cell antigen processing and presentation (GO:0002604)2.64493465
128positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.64165655
129positive regulation of natural killer cell differentiation (GO:0032825)2.63476400
130organelle membrane fusion (GO:0090174)2.62596678
131negative regulation of cytokine production involved in immune response (GO:0002719)2.62046513
132megakaryocyte development (GO:0035855)2.61929291
133regulation of interleukin-2 biosynthetic process (GO:0045076)2.61474125
134negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.58488422
135positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.58471643
136regulation of myeloid leukocyte mediated immunity (GO:0002886)2.57569505
137regulation of T cell apoptotic process (GO:0070232)2.56526858
138negative regulation of T cell apoptotic process (GO:0070233)2.55878441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.59607082
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.31351087
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.04740649
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.27937084
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.01174288
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.85982570
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.73495639
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.25433801
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.19228773
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.15731503
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15716579
12* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.96918595
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.95316375
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.92636912
15E2F7_22180533_ChIP-Seq_HELA_Human2.87376600
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.85102836
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.78153921
18SCL_19346495_ChIP-Seq_HPC-7_Human2.77862682
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.61287982
20SPI1_23547873_ChIP-Seq_NB4_Human2.58057439
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.42273071
22MYB_26560356_Chip-Seq_TH2_Human2.38010691
23* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.26883932
24RUNX_20019798_ChIP-Seq_JUKART_Human2.19646094
25MAF_26560356_Chip-Seq_TH1_Human2.15333158
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.12950301
27VDR_21846776_ChIP-Seq_THP-1_Human2.09458394
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09171414
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07105140
30* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05721392
31VDR_24763502_ChIP-Seq_THP-1_Human2.00735683
32* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00697983
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00437239
34MYC_22102868_ChIP-Seq_BL_Human1.95419839
35* MYB_26560356_Chip-Seq_TH1_Human1.92839608
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92595819
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89639645
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88553583
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80638848
40UTX_26944678_Chip-Seq_JUKART_Human1.78347840
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.69101953
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.67093412
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66863170
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66203258
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64849869
46SPI1_23127762_ChIP-Seq_K562_Human1.60455407
47PU_27001747_Chip-Seq_BMDM_Mouse1.53981439
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50555472
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46236495
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46160747
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45412201
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43741954
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42973210
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42932970
55GATA3_27048872_Chip-Seq_THYMUS_Human1.39274641
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38994266
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37802570
58MAF_26560356_Chip-Seq_TH2_Human1.35947061
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35033336
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33593854
61TCF7_22412390_ChIP-Seq_EML_Mouse1.31480998
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30914827
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30213788
64LXR_22292898_ChIP-Seq_THP-1_Human1.29244177
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26394605
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.23885912
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23424732
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22815782
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22010961
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20435505
71GATA3_26560356_Chip-Seq_TH2_Human1.18167964
72BCOR_27268052_Chip-Seq_Bcells_Human1.16215919
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15689153
74GATA1_19941826_ChIP-Seq_K562_Human1.14618940
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13352371
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10740479
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10264959
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.07645676
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06483177
80CIITA_25753668_ChIP-Seq_RAJI_Human1.05980657
81NCOR1_26117541_ChIP-Seq_K562_Human1.05801684
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05769343
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05739948
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05655559
85VDR_23849224_ChIP-Seq_CD4+_Human1.04989824
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.02623891
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02116196
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01755789
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01681248
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98988187
91STAT1_20625510_ChIP-Seq_HELA_Human0.98517718
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97440911
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97372172
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96411702
95ELK1_19687146_ChIP-ChIP_HELA_Human0.92403293
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92331197
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.90626113
98VDR_24787735_ChIP-Seq_THP-1_Human0.90167827
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.89892838
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89859725
101TFEB_21752829_ChIP-Seq_HELA_Human0.88482575
102GATA1_22025678_ChIP-Seq_K562_Human0.87507494
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87405922
104GABP_17652178_ChIP-ChIP_JURKAT_Human0.85670509
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82013488
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81875052
107FOXP3_21729870_ChIP-Seq_TREG_Human0.81522907
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78035212
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75202087
110SPI1_20517297_ChIP-Seq_HL60_Human0.74906272
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74034375
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72535413
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.72037021
114E2F4_17652178_ChIP-ChIP_JURKAT_Human0.71735043
115EST1_17652178_ChIP-ChIP_JURKAT_Human0.70965777
116KDM2B_26808549_Chip-Seq_DND41_Human0.69569498
117BCL6_27268052_Chip-Seq_Bcells_Human0.68520658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.60908312
2MP0009785_altered_susceptibility_to3.72812807
3MP0003436_decreased_susceptibility_to3.65860267
4MP0005671_abnormal_response_to3.61427881
5MP0002148_abnormal_hypersensitivity_rea3.25188907
6MP0005000_abnormal_immune_tolerance3.15844957
7MP0005025_abnormal_response_to3.06630977
8MP0000685_abnormal_immune_system3.00201335
9MP0003724_increased_susceptibility_to2.99091159
10MP0002419_abnormal_innate_immunity2.96543225
11MP0001800_abnormal_humoral_immune2.79077760
12MP0002452_abnormal_antigen_presenting2.75895712
13MP0006082_CNS_inflammation2.74382654
14MP0001790_abnormal_immune_system2.73008212
15MP0005387_immune_system_phenotype2.73008212
16MP0002723_abnormal_immune_serum2.71000573
17MP0002420_abnormal_adaptive_immunity2.62204351
18MP0001819_abnormal_immune_cell2.61956338
19MP0003763_abnormal_thymus_physiology2.53357160
20MP0003303_peritoneal_inflammation2.40032149
21MP0005464_abnormal_platelet_physiology2.36470715
22MP0009333_abnormal_splenocyte_physiolog2.34929070
23MP0002405_respiratory_system_inflammati2.29644414
24MP0002398_abnormal_bone_marrow2.18181261
25MP0002166_altered_tumor_susceptibility2.16963339
26MP0001853_heart_inflammation2.11109942
27MP0002396_abnormal_hematopoietic_system2.10138293
28MP0002006_tumorigenesis2.06983668
29MP0000716_abnormal_immune_system2.06506489
30MP0010155_abnormal_intestine_physiology1.99493799
31MP0004510_myositis1.93096194
32MP0001845_abnormal_inflammatory_respons1.90116136
33MP0005058_abnormal_lysosome_morphology1.89775508
34MP0001533_abnormal_skeleton_physiology1.87299408
35MP0000689_abnormal_spleen_morphology1.84611042
36MP0002722_abnormal_immune_system1.79481123
37MP0002429_abnormal_blood_cell1.73539873
38MP0004947_skin_inflammation1.71402490
39MP0001873_stomach_inflammation1.65770925
40MP0001545_abnormal_hematopoietic_system1.65533103
41MP0005397_hematopoietic_system_phenotyp1.65533103
42MP0003806_abnormal_nucleotide_metabolis1.62628927
43MP0000343_altered_response_to1.62351310
44MP0004808_abnormal_hematopoietic_stem1.58946847
45MP0000465_gastrointestinal_hemorrhage1.58535338
46MP0008469_abnormal_protein_level1.55453855
47MP0003448_altered_tumor_morphology1.54559535
48MP0002933_joint_inflammation1.51124929
49MP0005174_abnormal_tail_pigmentation1.50492771
50MP0002877_abnormal_melanocyte_morpholog1.49831625
51MP0000858_altered_metastatic_potential1.48770552
52MP0003300_gastrointestinal_ulcer1.47802989
53MP0000490_abnormal_crypts_of1.44212150
54MP0005310_abnormal_salivary_gland1.43700852
55MP0003866_abnormal_defecation1.41818302
56MP0003172_abnormal_lysosome_physiology1.41067494
57MP0000703_abnormal_thymus_morphology1.38680899
58MP0009764_decreased_sensitivity_to1.38671852
59MP0009278_abnormal_bone_marrow1.38080414
60MP0002998_abnormal_bone_remodeling1.25117521
61MP0001851_eye_inflammation1.09482079
62MP0003191_abnormal_cellular_cholesterol1.08791028
63MP0005075_abnormal_melanosome_morpholog1.04790331
64MP0005166_decreased_susceptibility_to1.02477714
65MP0003075_altered_response_to1.00736689
66MP0003828_pulmonary_edema0.98966768
67MP0002254_reproductive_system_inflammat0.97730582
68MP0009763_increased_sensitivity_to0.89097112
69MP0005390_skeleton_phenotype0.88560765
70MP0000015_abnormal_ear_pigmentation0.87382287
71MP0002019_abnormal_tumor_incidence0.86241400
72MP0010307_abnormal_tumor_latency0.83594573
73MP0002132_abnormal_respiratory_system0.83039223
74MP0000249_abnormal_blood_vessel0.78056169
75MP0004147_increased_porphyrin_level0.77115218
76MP0001542_abnormal_bone_strength0.75761194
77MP0003186_abnormal_redox_activity0.75731978
78MP0003786_premature_aging0.75627698
79MP0004782_abnormal_surfactant_physiolog0.74742320
80MP0005165_increased_susceptibility_to0.74222062
81MP0005167_abnormal_blood-brain_barrier0.74132537
82MP0002095_abnormal_skin_pigmentation0.72900352
83MP0003183_abnormal_peptide_metabolism0.72606393
84MP0001663_abnormal_digestive_system0.72379755
85MP0003795_abnormal_bone_structure0.71788669
86MP0006054_spinal_hemorrhage0.68820465
87MP0000372_irregular_coat_pigmentation0.66209852
88MP0008260_abnormal_autophagy0.65193837
89MP0008004_abnormal_stomach_pH0.64799767
90MP0005023_abnormal_wound_healing0.64447014
91MP0009840_abnormal_foam_cell0.62569723
92MP0005381_digestive/alimentary_phenotyp0.62121740
93MP0000371_diluted_coat_color0.61804558
94MP0005083_abnormal_biliary_tract0.61555591
95MP0004381_abnormal_hair_follicle0.59670430
96MP0005164_abnormal_response_to0.59033562
97MP0008007_abnormal_cellular_replicative0.58427013
98MP0002138_abnormal_hepatobiliary_system0.58235720
99MP0005451_abnormal_body_composition0.58180092
100MP0008873_increased_physiological_sensi0.56812523
101MP0003693_abnormal_embryo_hatching0.55106218
102MP0002277_abnormal_respiratory_mucosa0.54856607
103MP0003566_abnormal_cell_adhesion0.54043439
104MP0003453_abnormal_keratinocyte_physiol0.53106529
105MP0003638_abnormal_response/metabolism_0.52630719
106MP0010352_gastrointestinal_tract_polyps0.52236990
107MP0002136_abnormal_kidney_physiology0.51782102
108MP0000604_amyloidosis0.50164405
109MP0003279_aneurysm0.50152913
110MP0002693_abnormal_pancreas_physiology0.49969001
111MP0000313_abnormal_cell_death0.49291108
112MP0009765_abnormal_xenobiotic_induced0.49265227
113MP0005319_abnormal_enzyme/_coenzyme0.49132332
114MP0003656_abnormal_erythrocyte_physiolo0.47834877
115MP0004883_abnormal_blood_vessel0.44472036
116MP0003045_fibrosis0.42061400
117MP0008057_abnormal_DNA_replication0.41287590

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.42164342
2Eczematoid dermatitis (HP:0000976)5.90489686
3Elevated erythrocyte sedimentation rate (HP:0003565)5.63946792
4Recurrent bacterial skin infections (HP:0005406)5.48004387
5Myositis (HP:0100614)5.12253218
6Recurrent gram-negative bacterial infections (HP:0005420)4.35852103
7Mediastinal lymphadenopathy (HP:0100721)4.23300127
8Abnormality of macrophages (HP:0004311)4.16579781
9Recurrent fungal infections (HP:0002841)4.08190018
10Stomatitis (HP:0010280)4.07882891
11Orchitis (HP:0100796)4.02733851
12Obstructive lung disease (HP:0006536)3.90198999
13Chronic obstructive pulmonary disease (HP:0006510)3.90198999
14Recurrent skin infections (HP:0001581)3.88110530
15Optic neuritis (HP:0100653)3.83978679
16Retrobulbar optic neuritis (HP:0100654)3.83978679
17Vacuolated lymphocytes (HP:0001922)3.82354924
18IgM deficiency (HP:0002850)3.80502853
19Petechiae (HP:0000967)3.51379290
20Chronic otitis media (HP:0000389)3.51134474
21Chronic mucocutaneous candidiasis (HP:0002728)3.45348591
22Recurrent cutaneous fungal infections (HP:0011370)3.45348591
23Recurrent viral infections (HP:0004429)3.40616538
24Autoimmune thrombocytopenia (HP:0001973)3.32888971
25Gingivitis (HP:0000230)3.26693084
26Meningitis (HP:0001287)3.25898485
27Thrombocytosis (HP:0001894)3.25417519
28Vasculitis (HP:0002633)3.23602134
29Abnormality of T cell number (HP:0011839)3.20688861
30T lymphocytopenia (HP:0005403)3.18115235
31Increased neuronal autofluorescent lipopigment (HP:0002074)3.11397733
32Abnormality of T cells (HP:0002843)3.10324701
33Recurrent bronchitis (HP:0002837)3.08934404
34Increased cerebral lipofuscin (HP:0011813)3.06837776
35Pustule (HP:0200039)3.04649231
36Cellulitis (HP:0100658)2.89000707
37Spontaneous hematomas (HP:0007420)2.88930383
38Abnormality of T cell physiology (HP:0011840)2.85260601
39Nasal polyposis (HP:0100582)2.81470728
40Interstitial pulmonary disease (HP:0006530)2.79881057
41Abnormality of the nasal mucosa (HP:0000433)2.79464220
42Systemic lupus erythematosus (HP:0002725)2.77544643
43Pulmonary infiltrates (HP:0002113)2.76216020
44Basal ganglia calcification (HP:0002135)2.74181132
45Hemoptysis (HP:0002105)2.72972000
46IgG deficiency (HP:0004315)2.71365748
47Increased IgM level (HP:0003496)2.71163574
48Leukocytosis (HP:0001974)2.69962785
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.65406322
50Hypergammaglobulinemia (HP:0010702)2.64418154
51Hepatosplenomegaly (HP:0001433)2.63996230
52Prolonged bleeding time (HP:0003010)2.63674725
53Periodontitis (HP:0000704)2.60138261
54Lymphopenia (HP:0001888)2.54294175
55Epistaxis (HP:0000421)2.54010831
56Severe combined immunodeficiency (HP:0004430)2.53991138
57Arterial thrombosis (HP:0004420)2.52290267
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.50173092
59Autoimmune hemolytic anemia (HP:0001890)2.48473055
60Keratoconjunctivitis sicca (HP:0001097)2.48259565
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.47904788
62Combined immunodeficiency (HP:0005387)2.46826139
63Abnormality of the prostate (HP:0008775)2.46756414
64Loss of speech (HP:0002371)2.45313374
65Thyroiditis (HP:0100646)2.42539239
66Urticaria (HP:0001025)2.41853811
67Panhypogammaglobulinemia (HP:0003139)2.41604526
68Hypertensive crisis (HP:0100735)2.40659171
69Gingival bleeding (HP:0000225)2.38840467
70Purpura (HP:0000979)2.38714744
71Inflammation of the large intestine (HP:0002037)2.38026679
72Abnormality of liposaccharide metabolism (HP:0010968)2.31260645
73Abnormality of glycosphingolipid metabolism (HP:0004343)2.31260645
74Abnormality of glycolipid metabolism (HP:0010969)2.31260645
75Gastrointestinal inflammation (HP:0004386)2.30044952
76Increased serum ferritin (HP:0003281)2.29764464
77Dysostosis multiplex (HP:0000943)2.28475058
78Agnosia (HP:0010524)2.28055315
79Recurrent pneumonia (HP:0006532)2.27891106
80Gastrointestinal stroma tumor (HP:0100723)2.27008698
81Polyneuropathy (HP:0001271)2.26191076
82Encephalitis (HP:0002383)2.25895924
83Abnormality of eosinophils (HP:0001879)2.24272012
84Keratoconjunctivitis (HP:0001096)2.23474303
85Joint swelling (HP:0001386)2.22463510
86Chronic diarrhea (HP:0002028)2.21372553
87Episodic fever (HP:0001954)2.18057183
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17168178
89Abnormality of polysaccharide metabolism (HP:0011012)2.17168178
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17168178
91Glomerulopathy (HP:0100820)2.17000702
92Pulmonary fibrosis (HP:0002206)2.14658344
93Chest pain (HP:0100749)2.14248870
94Reduced antithrombin III activity (HP:0001976)2.14207077
95Poor head control (HP:0002421)2.13445036
96Eosinophilia (HP:0001880)2.12624846
97Pulmonary embolism (HP:0002204)2.12136647
98Osteomyelitis (HP:0002754)2.11851992
99Gangrene (HP:0100758)2.11812404
100Gastrointestinal infarctions (HP:0005244)2.10742528
101Abnormality of B cell number (HP:0010975)2.09023039
102Axonal loss (HP:0003447)2.08350019
103Disinhibition (HP:0000734)2.07738774
104Fatigue (HP:0012378)2.07698243
105Recurrent lower respiratory tract infections (HP:0002783)2.06859046
106Anorexia (HP:0002039)2.05688514
107Agammaglobulinemia (HP:0004432)2.05145900
108Lymphoma (HP:0002665)2.03596345
109Impaired platelet aggregation (HP:0003540)2.03002905
110Abnormal platelet function (HP:0011869)2.03002905
111Aplastic anemia (HP:0001915)2.02323215
112Abnormality of the pleura (HP:0002103)2.02240079
113Abnormality of iron homeostasis (HP:0011031)2.02176602
114Increased IgE level (HP:0003212)2.01359684
115Prostate neoplasm (HP:0100787)2.00808674
116Granulocytopenia (HP:0001913)2.00390757
117Skin ulcer (HP:0200042)1.99344322
118IgA deficiency (HP:0002720)1.98608591
119Albinism (HP:0001022)1.97731169
120Progressive neurologic deterioration (HP:0002344)1.97187498
121Spondylolisthesis (HP:0003302)1.96276864
122Mucopolysacchariduria (HP:0008155)1.96010647
123Urinary glycosaminoglycan excretion (HP:0003541)1.96010647
124Skin rash (HP:0000988)1.92833694

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.52662560
2TXK3.91401534
3BLK3.23666016
4KIT3.02663442
5IRAK43.00711041
6TBK12.76340932
7NME22.63635556
8ZAP702.55377323
9MAP3K142.53987319
10TYK22.43436446
11IKBKE2.41522347
12JAK32.41504086
13TEC2.39450349
14BTK2.19710041
15PIM22.14096666
16RIPK42.10956262
17TAOK11.95298101
18KDR1.92432947
19SYK1.78472548
20IKBKB1.74669820
21MAP3K121.69684535
22IRAK31.65667302
23ITK1.64441920
24CSF1R1.54427216
25TGFBR21.53598898
26LCK1.52511315
27HCK1.48553183
28MAP2K31.47861960
29JAK11.44718824
30ERN11.44002005
31CSK1.42198322
32STK101.41282875
33LYN1.37010470
34BMPR21.32526780
35FES1.29272729
36PIM11.26363006
37RPS6KA41.24050019
38FLT31.20303349
39PRPF4B1.18364155
40TAOK31.15958196
41LRRK21.14732383
42MKNK21.13546686
43NLK1.07508240
44MAP2K21.05545736
45CLK11.00700816
46FGFR40.95623580
47VRK20.95083068
48TGFBR10.94142079
49GRK60.89927738
50CHUK0.89725017
51TESK20.89117605
52MAP3K10.87867627
53MAPK70.85648580
54MAP3K110.82535900
55BCKDK0.80211684
56MST40.78647377
57MATK0.76710331
58FGFR30.76639907
59ADRBK20.74833411
60NEK90.74576673
61MAP2K60.74078973
62JAK20.72520657
63TNK20.71987347
64CAMKK20.70646104
65ARAF0.70160719
66ACVR1B0.70017692
67MOS0.68958691
68EPHB10.68121513
69MAP3K130.67183420
70TRPM70.66103101
71CDC42BPA0.63797710
72TLK10.61506344
73PTK2B0.60400274
74MARK30.57702582
75PKN20.57677860
76MAP3K30.54686751
77MAPK120.54414527
78PRKD20.54169163
79PRKCD0.54041069
80HIPK20.53760737
81EIF2AK30.53313130
82PAK40.53293790
83STK40.51401410
84PBK0.50239853
85STK160.50216758
86YES10.49554564
87BMX0.48486091
88PRKG20.48295306
89PDK10.47997290
90MUSK0.47813257
91ABL10.46867827
92SMG10.46370162
93MAPK110.46336782
94MYLK0.46109228
95PRKCQ0.45795551
96MAP3K50.45605517
97MAP3K80.44588891
98GRK70.44527258
99EIF2AK20.44070861
100ABL20.42210110
101MKNK10.41723682
102CDK40.41663695
103EEF2K0.41369437
104SIK30.40728013
105SCYL20.38709502
106IRAK10.38415430
107TAOK20.38098657
108RPS6KA60.37349207
109TESK10.36738138
110CDK60.36730787
111MAPKAPK20.36393103
112TIE10.35606151
113EIF2AK10.34707953
114MAPKAPK30.32811562
115MAPK40.31737454
116ILK0.31403372
117EGFR0.30815673
118TNIK0.29451859
119PDPK10.29422839
120RIPK10.28146665
121FYN0.27989555
122RPS6KA50.26411267
123PAK10.26400874
124FGR0.25835878
125IGF1R0.25637645
126VRK10.25581990
127DAPK10.23663951
128PIK3CG0.23431146

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.04874861
2Graft-versus-host disease_Homo sapiens_hsa053322.90665684
3Primary immunodeficiency_Homo sapiens_hsa053402.81195543
4Allograft rejection_Homo sapiens_hsa053302.59370979
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.58980167
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.44845467
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.35142366
8Measles_Homo sapiens_hsa051622.34446510
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.26881602
10Antigen processing and presentation_Homo sapiens_hsa046122.22331635
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.21976838
12Staphylococcus aureus infection_Homo sapiens_hsa051502.17579687
13Osteoclast differentiation_Homo sapiens_hsa043802.17228996
14Asthma_Homo sapiens_hsa053102.15896769
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08803478
16Hematopoietic cell lineage_Homo sapiens_hsa046402.08441371
17Legionellosis_Homo sapiens_hsa051341.97191527
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96378402
19Malaria_Homo sapiens_hsa051441.93760229
20Pertussis_Homo sapiens_hsa051331.80634645
21Other glycan degradation_Homo sapiens_hsa005111.75061622
22Tuberculosis_Homo sapiens_hsa051521.71465400
23B cell receptor signaling pathway_Homo sapiens_hsa046621.69306379
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64413133
25Herpes simplex infection_Homo sapiens_hsa051681.61466377
26T cell receptor signaling pathway_Homo sapiens_hsa046601.57072048
27Ribosome_Homo sapiens_hsa030101.56690273
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.53698409
29Shigellosis_Homo sapiens_hsa051311.47715487
30Lysosome_Homo sapiens_hsa041421.46527310
31Rheumatoid arthritis_Homo sapiens_hsa053231.43962002
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43921840
33Salmonella infection_Homo sapiens_hsa051321.43563100
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42834026
35DNA replication_Homo sapiens_hsa030301.41534941
36Influenza A_Homo sapiens_hsa051641.39783236
37Toxoplasmosis_Homo sapiens_hsa051451.39247815
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.31936568
39Autoimmune thyroid disease_Homo sapiens_hsa053201.27993241
40Apoptosis_Homo sapiens_hsa042101.27896193
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27029545
42TNF signaling pathway_Homo sapiens_hsa046681.26835318
43Type I diabetes mellitus_Homo sapiens_hsa049401.26346422
44Viral myocarditis_Homo sapiens_hsa054161.26078156
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20057274
46Chemokine signaling pathway_Homo sapiens_hsa040621.18881422
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15618921
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.13903138
49Phagosome_Homo sapiens_hsa041451.11025802
50Hepatitis B_Homo sapiens_hsa051611.10525413
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04318507
52Proteasome_Homo sapiens_hsa030500.99324742
53African trypanosomiasis_Homo sapiens_hsa051430.95009996
54Platelet activation_Homo sapiens_hsa046110.94164317
55Base excision repair_Homo sapiens_hsa034100.93279690
56Acute myeloid leukemia_Homo sapiens_hsa052210.92989229
57Caffeine metabolism_Homo sapiens_hsa002320.80108957
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79652114
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78006500
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77138727
61Mismatch repair_Homo sapiens_hsa034300.75563707
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75306459
63Epstein-Barr virus infection_Homo sapiens_hsa051690.74316725
64Hepatitis C_Homo sapiens_hsa051600.70061839
65Homologous recombination_Homo sapiens_hsa034400.69658847
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64218208
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60122605
68Pancreatic cancer_Homo sapiens_hsa052120.58497388
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56795754
70HTLV-I infection_Homo sapiens_hsa051660.56632973
71Viral carcinogenesis_Homo sapiens_hsa052030.54577911
72Chronic myeloid leukemia_Homo sapiens_hsa052200.54204255
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53787212
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50624470
75p53 signaling pathway_Homo sapiens_hsa041150.48757505
76Pyrimidine metabolism_Homo sapiens_hsa002400.47141094
77Non-homologous end-joining_Homo sapiens_hsa034500.45002953
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.44651159
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44647083
80Amoebiasis_Homo sapiens_hsa051460.44606219
81Protein export_Homo sapiens_hsa030600.44590035
82Collecting duct acid secretion_Homo sapiens_hsa049660.43086984
83Non-small cell lung cancer_Homo sapiens_hsa052230.43072449
84Pentose phosphate pathway_Homo sapiens_hsa000300.42250111
85Nucleotide excision repair_Homo sapiens_hsa034200.40431598
86Arachidonic acid metabolism_Homo sapiens_hsa005900.39456934
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38712168
88HIF-1 signaling pathway_Homo sapiens_hsa040660.37785046
89Spliceosome_Homo sapiens_hsa030400.35234481
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34605976
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34512337
92Renin-angiotensin system_Homo sapiens_hsa046140.34469757
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.33957021
94Prolactin signaling pathway_Homo sapiens_hsa049170.33869642
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33384993
96VEGF signaling pathway_Homo sapiens_hsa043700.33242449
97RNA polymerase_Homo sapiens_hsa030200.32806621
98N-Glycan biosynthesis_Homo sapiens_hsa005100.32354277
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.31994656
100Small cell lung cancer_Homo sapiens_hsa052220.31200392
101Galactose metabolism_Homo sapiens_hsa000520.29703577
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29127287
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29027088
104Bladder cancer_Homo sapiens_hsa052190.28269471
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.26904416
106Endocytosis_Homo sapiens_hsa041440.26849533
107Sulfur metabolism_Homo sapiens_hsa009200.26362567
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25312780
109Systemic lupus erythematosus_Homo sapiens_hsa053220.25245907
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24325862
111RNA degradation_Homo sapiens_hsa030180.23738133
112Sphingolipid metabolism_Homo sapiens_hsa006000.23654257
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23578938
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20219508
115MAPK signaling pathway_Homo sapiens_hsa040100.19619535
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.19045856

Most similar genes based on co-expression Upload to Enrichr

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