ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of type B pancreatic cell apoptotic process (GO:2000674)	5.04906725
2	cellular ketone body metabolic process (GO:0046950)	5.00191329
3	ketone body metabolic process (GO:1902224)	4.41372783
4	epithelial cell fate commitment (GO:0072148)	4.28842586
5	insulin secretion (GO:0030073)	4.27191017
6	glycerophospholipid catabolic process (GO:0046475)	4.22789714
7	regulation of glucokinase activity (GO:0033131)	4.21608323
8	regulation of hexokinase activity (GO:1903299)	4.21608323
9	endocrine pancreas development (GO:0031018)	4.20164380
10	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	4.08443421
11	detection of calcium ion (GO:0005513)	3.97024772
12	inositol phosphate catabolic process (GO:0071545)	3.83041727
13	positive regulation of insulin secretion (GO:0032024)	3.82874569
14	nitric oxide mediated signal transduction (GO:0007263)	3.65537471
15	water-soluble vitamin biosynthetic process (GO:0042364)	3.60338082
16	respiratory chain complex IV assembly (GO:0008535)	3.57245778
17	peptide hormone processing (GO:0016486)	3.55955914
18	positive regulation of glycolytic process (GO:0045821)	3.52586115
19	auditory receptor cell differentiation (GO:0042491)	3.48337033
20	positive regulation of peptide hormone secretion (GO:0090277)	3.46334367
21	signal peptide processing (GO:0006465)	3.46182662
22	dendritic spine morphogenesis (GO:0060997)	3.46178011
23	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.42160701
24	positive regulation of peptide secretion (GO:0002793)	3.37616588
25	negative regulation of execution phase of apoptosis (GO:1900118)	3.36497493
26	L-phenylalanine catabolic process (GO:0006559)	3.34785008
27	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.34785008
28	inositol phosphate dephosphorylation (GO:0046855)	3.32093369
29	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.32093369
30	lactate metabolic process (GO:0006089)	3.27983993
31	cytochrome complex assembly (GO:0017004)	3.24171372
32	protein complex biogenesis (GO:0070271)	3.22995098
33	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.16766671
34	positive regulation of meiosis (GO:0045836)	3.15449385
35	xenobiotic catabolic process (GO:0042178)	3.15427782
36	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.08314056
37	L-phenylalanine metabolic process (GO:0006558)	3.08314056
38	L-alpha-amino acid transmembrane transport (GO:1902475)	3.06307278
39	glandular epithelial cell differentiation (GO:0002067)	3.02447097
40	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.01476002
41	kidney morphogenesis (GO:0060993)	2.98419521
42	regulation of insulin secretion (GO:0050796)	2.96594768
43	dentate gyrus development (GO:0021542)	2.96227439
44	regulation of mitochondrial translation (GO:0070129)	2.95828326
45	negative regulation of neurological system process (GO:0031645)	2.94277093
46	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.94162316
47	positive regulation of meiotic cell cycle (GO:0051446)	2.92828364
48	platelet dense granule organization (GO:0060155)	2.88902130
49	protein prenylation (GO:0018342)	2.86389639
50	prenylation (GO:0097354)	2.86389639
51	L-fucose catabolic process (GO:0042355)	2.85737408
52	fucose catabolic process (GO:0019317)	2.85737408
53	L-fucose metabolic process (GO:0042354)	2.85737408
54	brain morphogenesis (GO:0048854)	2.85534868
55	peptide hormone secretion (GO:0030072)	2.85141321
56	phenylpropanoid metabolic process (GO:0009698)	2.83520870
57	mitochondrial respiratory chain complex assembly (GO:0033108)	2.83181957
58	regulation of autophagic vacuole assembly (GO:2000785)	2.81948337
59	glucosamine-containing compound catabolic process (GO:1901072)	2.76949767
60	peptide secretion (GO:0002790)	2.76154164
61	polyol catabolic process (GO:0046174)	2.75851891
62	regulation of peptide hormone secretion (GO:0090276)	2.73688329
63	axoneme assembly (GO:0035082)	2.71843092
64	protein localization to cilium (GO:0061512)	2.71705581
65	negative regulation of gluconeogenesis (GO:0045721)	2.69834920
66	regulation of peptide secretion (GO:0002791)	2.68452216
67	aromatic amino acid family catabolic process (GO:0009074)	2.67077922
68	sphingomyelin metabolic process (GO:0006684)	2.66247043
69	pigment granule transport (GO:0051904)	2.65599858
70	dopamine transport (GO:0015872)	2.65526382
71	response to pheromone (GO:0019236)	2.65304880
72	melanosome transport (GO:0032402)	2.63722097
73	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.62261347
74	neuron fate determination (GO:0048664)	2.61867020
75	negative regulation of protein oligomerization (GO:0032460)	2.60691509
76	positive regulation of calcium ion import (GO:0090280)	2.60151717
77	positive regulation of hormone secretion (GO:0046887)	2.58492056
78	pteridine-containing compound biosynthetic process (GO:0042559)	2.57503224
79	protein localization to Golgi apparatus (GO:0034067)	2.56339712
80	protein targeting to Golgi (GO:0000042)	2.55806387
81	positive regulation of gluconeogenesis (GO:0045722)	2.54580862
82	nonmotile primary cilium assembly (GO:0035058)	2.53371867
83	alanine transport (GO:0032328)	2.52448186
84	pancreas development (GO:0031016)	2.51753186
85	intra-Golgi vesicle-mediated transport (GO:0006891)	2.50826201
86	establishment of pigment granule localization (GO:0051905)	2.50777301
87	zinc ion homeostasis (GO:0055069)	2.49568590
88	proline transport (GO:0015824)	2.49360975
89	keratinocyte development (GO:0003334)	2.48763090
90	establishment of melanosome localization (GO:0032401)	2.48311140
91	regulation of hormone secretion (GO:0046883)	2.46163925
92	establishment of protein localization to Golgi (GO:0072600)	2.44141403
93	nitric oxide biosynthetic process (GO:0006809)	2.42837824
94	adaptation of signaling pathway (GO:0023058)	2.42791118
95	response to dietary excess (GO:0002021)	2.40547752
96	regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)	2.40125637
97	regulation of vacuole organization (GO:0044088)	2.39093734
98	neuron fate specification (GO:0048665)	2.38701398
99	toxin metabolic process (GO:0009404)	2.38209697
100	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.37085624

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	8.29406785
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.21803530
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.72373460
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.44610201
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40641292
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.39375465
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36373546
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.14323486
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.08492595
10	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.03516084
11	VDR_22108803_ChIP-Seq_LS180_Human	1.95475581
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92579188
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92287461
14	FUS_26573619_Chip-Seq_HEK293_Human	1.92184596
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.82368595
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74781125
17	P300_19829295_ChIP-Seq_ESCs_Human	1.73297745
18	BCAT_22108803_ChIP-Seq_LS180_Human	1.70400161
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68612133
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.66217210
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64516768
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62987234
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.61573239
24	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.58464169
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.57444814
26	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.56025397
27	AR_25329375_ChIP-Seq_VCAP_Human	1.54554090
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49268802
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46615502
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46088801
31	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.45033305
32	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44677407
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44155319
34	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43047776
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.41960828
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41960828
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40181634
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.39815216
39	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.39039430
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38099470
41	HTT_18923047_ChIP-ChIP_STHdh_Human	1.36296604
42	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.32786404
43	STAT3_23295773_ChIP-Seq_U87_Human	1.32167588
44	EWS_26573619_Chip-Seq_HEK293_Human	1.31587156
45	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.31201913
46	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.29800159
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29013066
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27750052
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27750052
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27723569
51	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.25620299
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25604186
53	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24915127
54	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.23930236
55	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.22973374
56	TCF4_23295773_ChIP-Seq_U87_Human	1.20682516
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.19901333
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18459050
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18459050
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18052421
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17155393
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.15862139
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.15056128
64	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14968090
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.13468281
66	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.12709797
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11724262
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11009622
69	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.10889666
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10696428
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10520701
72	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.10254351
73	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.08782359
74	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.08768380
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08271075
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07620877
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.06807940
78	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06803589
79	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06023246
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05549044
81	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.05409518
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04457826
83	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.03957972
84	AR_20517297_ChIP-Seq_VCAP_Human	1.03084193
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03026004
86	PHF8_20622853_ChIP-Seq_HELA_Human	1.02481202
87	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.02093155
88	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02073777
89	EZH2_22144423_ChIP-Seq_EOC_Human	1.00726885
90	NCOR_22424771_ChIP-Seq_293T_Human	1.00638252
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00333159
92	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00203347
93	P300_18555785_Chip-Seq_ESCs_Mouse	0.98616951
94	TBL1_22424771_ChIP-Seq_293T_Human	0.98434651
95	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.98229913
96	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.98154547
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97853248
98	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.97465461
99	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.96842545
100	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.96469822

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	5.21443020
2	MP0005379_endocrine/exocrine_gland_phen	3.73098666
3	MP0002909_abnormal_adrenal_gland	3.36373740
4	MP0003787_abnormal_imprinting	3.22783120
5	MP0002163_abnormal_gland_morphology	2.89509959
6	MP0005645_abnormal_hypothalamus_physiol	2.77644683
7	MP0006072_abnormal_retinal_apoptosis	2.74487279
8	MP0003195_calcinosis	2.71752954
9	MP0003122_maternal_imprinting	2.71691257
10	MP0009780_abnormal_chondrocyte_physiolo	2.62093326
11	MP0000013_abnormal_adipose_tissue	2.55607242
12	MP0003283_abnormal_digestive_organ	2.49464330
13	MP0008877_abnormal_DNA_methylation	2.49293619
14	MP0001944_abnormal_pancreas_morphology	2.41603380
15	MP0002876_abnormal_thyroid_physiology	2.33952563
16	MP0009046_muscle_twitch	2.27918973
17	MP0002693_abnormal_pancreas_physiology	2.16752467
18	MP0010386_abnormal_urinary_bladder	2.03904632
19	MP0010234_abnormal_vibrissa_follicle	1.96700612
20	MP0004270_analgesia	1.90401562
21	MP0001984_abnormal_olfaction	1.90292908
22	MP0001501_abnormal_sleep_pattern	1.86917035
23	MP0005220_abnormal_exocrine_pancreas	1.84449178
24	MP0005646_abnormal_pituitary_gland	1.83296174
25	MP0003121_genomic_imprinting	1.74226488
26	MP0002254_reproductive_system_inflammat	1.72457983
27	MP0001756_abnormal_urination	1.69601681
28	MP0005332_abnormal_amino_acid	1.64603885
29	MP0005551_abnormal_eye_electrophysiolog	1.59855488
30	MP0002078_abnormal_glucose_homeostasis	1.58145856
31	MP0002139_abnormal_hepatobiliary_system	1.56847094
32	MP0002272_abnormal_nervous_system	1.56833784
33	MP0009745_abnormal_behavioral_response	1.54584283
34	MP0005253_abnormal_eye_physiology	1.50418907
35	MP0004215_abnormal_myocardial_fiber	1.48739091
36	MP0010329_abnormal_lipoprotein_level	1.44375016
37	MP0000631_abnormal_neuroendocrine_gland	1.42340905
38	MP0004019_abnormal_vitamin_homeostasis	1.38216332
39	MP0002638_abnormal_pupillary_reflex	1.38107125
40	MP0005084_abnormal_gallbladder_morpholo	1.36263962
41	MP0000569_abnormal_digit_pigmentation	1.31893050
42	MP0002064_seizures	1.30452523
43	MP0004043_abnormal_pH_regulation	1.28250898
44	MP0004133_heterotaxia	1.27318392
45	MP0003011_delayed_dark_adaptation	1.26844759
46	MP0001905_abnormal_dopamine_level	1.24255816
47	MP0002557_abnormal_social/conspecific_i	1.23028140
48	MP0004885_abnormal_endolymph	1.18848950
49	MP0004142_abnormal_muscle_tone	1.18542559
50	MP0006036_abnormal_mitochondrial_physio	1.17377292
51	MP0003123_paternal_imprinting	1.17085155
52	MP0002572_abnormal_emotion/affect_behav	1.17064029
53	MP0002928_abnormal_bile_duct	1.16231412
54	MP0006276_abnormal_autonomic_nervous	1.15144133
55	MP0005174_abnormal_tail_pigmentation	1.12554573
56	MP0002734_abnormal_mechanical_nocicepti	1.11469932
57	MP0003172_abnormal_lysosome_physiology	1.11340454
58	MP0002090_abnormal_vision	1.10939400
59	MP0002938_white_spotting	1.10029853
60	MP0000427_abnormal_hair_cycle	1.09802254
61	MP0005448_abnormal_energy_balance	1.09384120
62	MP0000639_abnormal_adrenal_gland	1.08907440
63	MP0003953_abnormal_hormone_level	1.08224133
64	MP0005636_abnormal_mineral_homeostasis	1.07899049
65	MP0001529_abnormal_vocalization	1.07628946
66	MP0004924_abnormal_behavior	1.02803128
67	MP0005386_behavior/neurological_phenoty	1.02803128
68	MP0004085_abnormal_heartbeat	1.01138943
69	MP0000538_abnormal_urinary_bladder	1.00564617
70	MP0001968_abnormal_touch/_nociception	0.98848134
71	MP0005535_abnormal_body_temperature	0.97789784
72	MP0001765_abnormal_ion_homeostasis	0.96887200
73	MP0003879_abnormal_hair_cell	0.96840992
74	MP0001970_abnormal_pain_threshold	0.96674595
75	MP0003633_abnormal_nervous_system	0.95736853
76	MP0001486_abnormal_startle_reflex	0.91082861
77	MP0000516_abnormal_urinary_system	0.89308076
78	MP0005367_renal/urinary_system_phenotyp	0.89308076
79	MP0002102_abnormal_ear_morphology	0.85969168
80	MP0002069_abnormal_eating/drinking_beha	0.85907861
81	MP0000372_irregular_coat_pigmentation	0.85862413
82	MP0002229_neurodegeneration	0.85307920
83	MP0001485_abnormal_pinna_reflex	0.84647966
84	MP0005389_reproductive_system_phenotype	0.83029943
85	MP0002733_abnormal_thermal_nociception	0.81358936
86	MP0000003_abnormal_adipose_tissue	0.80675636
87	MP0003137_abnormal_impulse_conducting	0.79495305
88	MP0005187_abnormal_penis_morphology	0.78693787
89	MP0008872_abnormal_physiological_respon	0.78653540
90	MP0002063_abnormal_learning/memory/cond	0.78504957
91	MP0001502_abnormal_circadian_rhythm	0.78286730
92	MP0001661_extended_life_span	0.77544429
93	MP0002160_abnormal_reproductive_system	0.76294752
94	MP0003635_abnormal_synaptic_transmissio	0.76149755
95	MP0001764_abnormal_homeostasis	0.74591495
96	MP0002295_abnormal_pulmonary_circulatio	0.73476580
97	MP0008775_abnormal_heart_ventricle	0.73371701
98	MP0005075_abnormal_melanosome_morpholog	0.72486011
99	MP0002118_abnormal_lipid_homeostasis	0.72284619
100	MP0001986_abnormal_taste_sensitivity	0.71248257

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic coma (HP:0001325)	4.85696100
2	Hypoglycemic seizures (HP:0002173)	4.63531423
3	Hypothermia (HP:0002045)	4.57763289
4	Hyperinsulinemic hypoglycemia (HP:0000825)	4.36157858
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.93467632
6	Ketoacidosis (HP:0001993)	3.83679591
7	Hypomagnesemia (HP:0002917)	3.76612418
8	Large for gestational age (HP:0001520)	3.69199325
9	Hyperglycemia (HP:0003074)	3.60490683
10	Progressive macrocephaly (HP:0004481)	3.21635743
11	Symptomatic seizures (HP:0011145)	3.20210084
12	Abnormality of endocrine pancreas physiology (HP:0012093)	3.12147623
13	Abnormality of the pancreatic islet cells (HP:0006476)	3.12147623
14	Medial flaring of the eyebrow (HP:0010747)	3.05591214
15	Ketosis (HP:0001946)	2.92390833
16	Abnormality of magnesium homeostasis (HP:0004921)	2.89297283
17	Acute necrotizing encephalopathy (HP:0006965)	2.89238293
18	Congenital malformation of the right heart (HP:0011723)	2.85302225
19	Double outlet right ventricle (HP:0001719)	2.85302225
20	Abnormality of the renal cortex (HP:0011035)	2.82563632
21	Abnormality of vitamin B metabolism (HP:0004340)	2.79085097
22	Hemiparesis (HP:0001269)	2.76705808
23	Intestinal atresia (HP:0011100)	2.75474091
24	EEG with generalized epileptiform discharges (HP:0011198)	2.74751616
25	Renal cortical cysts (HP:0000803)	2.69095009
26	Epileptiform EEG discharges (HP:0011182)	2.67001246
27	Agitation (HP:0000713)	2.62095168
28	Hypsarrhythmia (HP:0002521)	2.60434644
29	Pancreatic fibrosis (HP:0100732)	2.54967928
30	Hepatic necrosis (HP:0002605)	2.53709317
31	Late onset (HP:0003584)	2.53433581
32	Pancreatic cysts (HP:0001737)	2.50425387
33	Gait imbalance (HP:0002141)	2.45362672
34	Tongue fasciculations (HP:0001308)	2.44359916
35	Nephronophthisis (HP:0000090)	2.44358360
36	Mitochondrial inheritance (HP:0001427)	2.43961791
37	Poor suck (HP:0002033)	2.39844277
38	Glycosuria (HP:0003076)	2.39487904
39	Abnormality of urine glucose concentration (HP:0011016)	2.39487904
40	Methylmalonic acidemia (HP:0002912)	2.37344872
41	Congenital primary aphakia (HP:0007707)	2.37200566
42	Insulin-resistant diabetes mellitus (HP:0000831)	2.36523764
43	Enlarged penis (HP:0000040)	2.35914855
44	Abnormal mitochondria in muscle tissue (HP:0008316)	2.33559090
45	Increased CSF lactate (HP:0002490)	2.30593086
46	Polyphagia (HP:0002591)	2.29803998
47	Pancreatic islet-cell hyperplasia (HP:0004510)	2.27626920
48	Lipid accumulation in hepatocytes (HP:0006561)	2.26598320
49	Acute encephalopathy (HP:0006846)	2.25044284
50	Generalized aminoaciduria (HP:0002909)	2.23403350
51	Arthropathy (HP:0003040)	2.21135928
52	True hermaphroditism (HP:0010459)	2.18962493
53	Muscular hypotonia of the trunk (HP:0008936)	2.17622711
54	Increased hepatocellular lipid droplets (HP:0006565)	2.17368452
55	Tubular atrophy (HP:0000092)	2.17284541
56	Limb dystonia (HP:0002451)	2.15211187
57	Congenital stationary night blindness (HP:0007642)	2.15038381
58	Polydipsia (HP:0001959)	2.11661746
59	Abnormal drinking behavior (HP:0030082)	2.11661746
60	Sex reversal (HP:0012245)	2.11385890
61	Abnormal sex determination (HP:0012244)	2.11385890
62	Abnormality of vitamin metabolism (HP:0100508)	2.11022390
63	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.10756446
64	Hypoplasia of the fovea (HP:0007750)	2.10756446
65	Nephrogenic diabetes insipidus (HP:0009806)	2.07102012
66	Methylmalonic aciduria (HP:0012120)	2.07058757
67	Increased CSF protein (HP:0002922)	2.04480520
68	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.03009635
69	Furrowed tongue (HP:0000221)	2.02025003
70	Abnormality of the renal medulla (HP:0100957)	2.01448389
71	Neoplasm of the adrenal cortex (HP:0100641)	2.01302786
72	Abnormality of the labia minora (HP:0012880)	1.99869341
73	Muscle fibrillation (HP:0010546)	1.99863329
74	Hepatocellular necrosis (HP:0001404)	1.96811812
75	3-Methylglutaconic aciduria (HP:0003535)	1.91067344
76	Progressive neurologic deterioration (HP:0002344)	1.89823314
77	Severe muscular hypotonia (HP:0006829)	1.88822025
78	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.88017464
79	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.88017464
80	Unilateral renal agenesis (HP:0000122)	1.87884725
81	Hyperventilation (HP:0002883)	1.86702303
82	Congenital sensorineural hearing impairment (HP:0008527)	1.85133375
83	Anxiety (HP:0000739)	1.82704258
84	Abnormality of midbrain morphology (HP:0002418)	1.81803430
85	Molar tooth sign on MRI (HP:0002419)	1.81803430
86	Abnormal albumin level (HP:0012116)	1.80640112
87	Hypoalbuminemia (HP:0003073)	1.80640112
88	Hematochezia (HP:0002573)	1.78571394
89	Dicarboxylic aciduria (HP:0003215)	1.78005586
90	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.78005586
91	Abnormal pancreas size (HP:0012094)	1.77998490
92	Hypokinesia (HP:0002375)	1.77696472
93	Genital tract atresia (HP:0001827)	1.77655613
94	Type II lissencephaly (HP:0007260)	1.76986509
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.75439491
96	Gaze-evoked nystagmus (HP:0000640)	1.74909778
97	Abnormality of fatty-acid metabolism (HP:0004359)	1.74601865
98	Type I diabetes mellitus (HP:0100651)	1.73059324
99	Cerebral edema (HP:0002181)	1.72976372
100	Renal Fanconi syndrome (HP:0001994)	1.71045071

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.85323993
2	MAP4K2	3.73556353
3	FGFR2	3.29813659
4	PINK1	3.14127183
5	WNK3	3.12717275
6	PHKG2	2.64632951
7	PHKG1	2.64632951
8	MST4	2.53130744
9	ADRBK2	2.22620730
10	GRK1	2.11059183
11	NTRK3	1.90744535
12	BMPR1B	1.89898801
13	MAP3K4	1.89630423
14	CASK	1.84475852
15	PAK3	1.81108500
16	FER	1.68109090
17	DAPK2	1.62382946
18	EIF2AK3	1.52469961
19	MAP2K6	1.49507124
20	PRKCE	1.46146238
21	ZAK	1.42448947
22	PNCK	1.39164765
23	TAOK1	1.38261231
24	EPHA3	1.30166275
25	TNIK	1.29384785
26	MAPK13	1.25484980
27	STK38L	1.20355850
28	NLK	1.19908753
29	INSRR	1.19869827
30	PASK	1.19520064
31	CSNK1G1	1.18386550
32	PLK2	1.16457024
33	PRKCG	1.11095050
34	MAP3K9	1.08763230
35	FGFR3	1.04684458
36	ERBB3	1.04155907
37	WNK4	1.02336124
38	MAP3K2	0.98280763
39	MARK1	0.96775530
40	MAPKAPK3	0.96351026
41	CSNK1G3	0.92186158
42	STK3	0.91127163
43	MAP2K7	0.90865094
44	CSNK1G2	0.88275055
45	CAMK2D	0.86777490
46	ACVR1B	0.84181032
47	MAP3K12	0.83592596
48	AKT3	0.80446414
49	NME1	0.79556429
50	TLK1	0.76268266
51	IRAK2	0.75337773
52	UHMK1	0.74059368
53	CDK3	0.73674130
54	YES1	0.69566617
55	DYRK2	0.68706343
56	STK11	0.68388747
57	TRPM7	0.65768632
58	PRKCI	0.62602879
59	PLK3	0.62238069
60	IRAK1	0.61030149
61	LIMK1	0.59812044
62	PRKG1	0.59186977
63	MKNK2	0.57357543
64	PRKAA1	0.55403548
65	CAMK2A	0.55185160
66	CSNK1A1L	0.53388499
67	SGK2	0.51879322
68	PRKACA	0.51022058
69	PRKG2	0.50926145
70	TIE1	0.49948470
71	HIPK2	0.49457822
72	OBSCN	0.48676793
73	SGK494	0.48134188
74	SGK223	0.48134188
75	MYLK	0.43872774
76	OXSR1	0.43134620
77	PRKCZ	0.41402184
78	PTK2B	0.41401474
79	PRKD2	0.41113522
80	ADRBK1	0.40869071
81	PRKAA2	0.40042107
82	CSNK1A1	0.39766496
83	PRKACB	0.39017772
84	CAMKK2	0.38448369
85	STK4	0.38242529
86	NUAK1	0.37535073
87	ROCK1	0.36228824
88	DAPK3	0.35925456
89	CAMK1	0.33550635
90	NTRK2	0.32349797
91	RPS6KA5	0.31765139
92	PRKCA	0.31410256
93	CAMK2B	0.30164726
94	SGK1	0.29804487
95	CSNK1D	0.29216093
96	STK39	0.29125296
97	PIK3CA	0.28818909
98	VRK1	0.27495759
99	LMTK2	0.26369402
100	CDK5	0.25972513

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	5.66060071
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.98119535
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.93879513
4	Butanoate metabolism_Homo sapiens_hsa00650	2.91849150
5	Protein export_Homo sapiens_hsa03060	2.88640680
6	Insulin secretion_Homo sapiens_hsa04911	2.56074001
7	Folate biosynthesis_Homo sapiens_hsa00790	2.22479162
8	Collecting duct acid secretion_Homo sapiens_hsa04966	2.18821703
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.02476549
10	Parkinsons disease_Homo sapiens_hsa05012	1.98385724
11	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.85079252
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80574479
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.79260112
14	Sulfur metabolism_Homo sapiens_hsa00920	1.73755228
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.69290946
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.56432258
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.52577193
18	Alzheimers disease_Homo sapiens_hsa05010	1.45098004
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.44753166
20	Regulation of autophagy_Homo sapiens_hsa04140	1.42670170
21	Peroxisome_Homo sapiens_hsa04146	1.40975571
22	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.37912981
23	Phototransduction_Homo sapiens_hsa04744	1.29848123
24	Circadian rhythm_Homo sapiens_hsa04710	1.29789007
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.28979977
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.27258440
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24349554
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.19564651
29	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.18302619
30	Renin secretion_Homo sapiens_hsa04924	1.15934509
31	Mineral absorption_Homo sapiens_hsa04978	1.15678654
32	GABAergic synapse_Homo sapiens_hsa04727	1.15317743
33	Circadian entrainment_Homo sapiens_hsa04713	1.14874550
34	Huntingtons disease_Homo sapiens_hsa05016	1.13371902
35	Amphetamine addiction_Homo sapiens_hsa05031	1.10822688
36	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.10363122
37	Propanoate metabolism_Homo sapiens_hsa00640	1.09768338
38	Fatty acid elongation_Homo sapiens_hsa00062	1.05279915
39	Sphingolipid metabolism_Homo sapiens_hsa00600	1.04383175
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01041833
41	Vibrio cholerae infection_Homo sapiens_hsa05110	1.00239993
42	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99906367
43	Type I diabetes mellitus_Homo sapiens_hsa04940	0.99392630
44	Linoleic acid metabolism_Homo sapiens_hsa00591	0.98313586
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96413019
46	Serotonergic synapse_Homo sapiens_hsa04726	0.95864388
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.95453229
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95119493
49	ABC transporters_Homo sapiens_hsa02010	0.93720935
50	Nicotine addiction_Homo sapiens_hsa05033	0.92086348
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.91173274
52	Type II diabetes mellitus_Homo sapiens_hsa04930	0.90375941
53	Taste transduction_Homo sapiens_hsa04742	0.88663805
54	Glutamatergic synapse_Homo sapiens_hsa04724	0.88651575
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88035926
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83993909
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83078113
58	Cocaine addiction_Homo sapiens_hsa05030	0.82828521
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81285665
60	Salivary secretion_Homo sapiens_hsa04970	0.81218047
61	Morphine addiction_Homo sapiens_hsa05032	0.75023420
62	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.72612902
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70391889
64	RNA polymerase_Homo sapiens_hsa03020	0.70261287
65	Caffeine metabolism_Homo sapiens_hsa00232	0.69080823
66	Fatty acid degradation_Homo sapiens_hsa00071	0.68579966
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.67359796
68	Glucagon signaling pathway_Homo sapiens_hsa04922	0.67279337
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.66816856
70	Metabolic pathways_Homo sapiens_hsa01100	0.66600283
71	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.66433408
72	Long-term depression_Homo sapiens_hsa04730	0.65862011
73	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65784705
74	Retinol metabolism_Homo sapiens_hsa00830	0.64123450
75	Basal transcription factors_Homo sapiens_hsa03022	0.63351390
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62096786
77	Glutathione metabolism_Homo sapiens_hsa00480	0.61989922
78	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.59484954
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.55705977
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55213962
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54717085
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.54601851
83	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.53553462
84	RNA degradation_Homo sapiens_hsa03018	0.53079564
85	Pancreatic secretion_Homo sapiens_hsa04972	0.52432252
86	Arginine biosynthesis_Homo sapiens_hsa00220	0.52215265
87	Olfactory transduction_Homo sapiens_hsa04740	0.50560733
88	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.47895875
89	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.47029402
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.45983699
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.45851961
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.45794180
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.45229913
94	Purine metabolism_Homo sapiens_hsa00230	0.45045020
95	Gastric acid secretion_Homo sapiens_hsa04971	0.42903707
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.41944186
97	Histidine metabolism_Homo sapiens_hsa00340	0.39772362
98	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38457378
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38442666
100	Bile secretion_Homo sapiens_hsa04976	0.37143825

FXYD6-FXYD2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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