FXYD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]. SAMEA1966682, SAMEA1968968 [ECO:0000348] NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)7.99562326
2synaptic vesicle exocytosis (GO:0016079)5.81010397
3negative regulation of dendrite morphogenesis (GO:0050774)5.43799273
4neuronal action potential propagation (GO:0019227)5.41095039
5synaptic vesicle maturation (GO:0016188)5.36156257
6glutamate secretion (GO:0014047)5.29448178
7cellular potassium ion homeostasis (GO:0030007)5.16943032
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.11956781
9regulation of synaptic vesicle exocytosis (GO:2000300)4.84694953
10cell migration in hindbrain (GO:0021535)4.67304458
11neurotransmitter secretion (GO:0007269)4.57939066
12sodium ion export (GO:0071436)4.51401590
13positive regulation of synapse maturation (GO:0090129)4.49481518
14cerebellar granule cell differentiation (GO:0021707)4.49329204
15detection of temperature stimulus involved in sensory perception (GO:0050961)4.46367004
16detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.46367004
17protein localization to synapse (GO:0035418)4.43562664
18detection of temperature stimulus (GO:0016048)4.33332258
19vocalization behavior (GO:0071625)4.27744684
20neuron cell-cell adhesion (GO:0007158)4.25986182
21calcium-mediated signaling using intracellular calcium source (GO:0035584)4.21194657
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.20811936
23negative regulation of microtubule polymerization (GO:0031115)4.20388765
24gamma-aminobutyric acid transport (GO:0015812)4.18556982
25regulation of synaptic vesicle transport (GO:1902803)4.18352310
26L-amino acid import (GO:0043092)4.18093070
27negative regulation of dendrite development (GO:2000171)4.16724217
28positive regulation of dendritic spine development (GO:0060999)4.15421003
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.11036863
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.10978848
31synaptic vesicle docking involved in exocytosis (GO:0016081)4.07742666
32neuronal ion channel clustering (GO:0045161)3.95455861
33positive regulation of dendritic spine morphogenesis (GO:0061003)3.94928532
34neuromuscular process controlling posture (GO:0050884)3.89166951
35positive regulation of membrane potential (GO:0045838)3.88852297
36proline transport (GO:0015824)3.87377783
37central nervous system myelination (GO:0022010)3.84367640
38axon ensheathment in central nervous system (GO:0032291)3.84367640
39dendritic spine morphogenesis (GO:0060997)3.73324222
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.72394421
41intermediate filament organization (GO:0045109)3.71064636
42amino acid import (GO:0043090)3.70415341
43sleep (GO:0030431)3.67217165
44exploration behavior (GO:0035640)3.66844211
45regulation of synapse maturation (GO:0090128)3.63205604
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.63025648
47regulation of neuronal synaptic plasticity (GO:0048168)3.62486427
48locomotory exploration behavior (GO:0035641)3.60499407
49potassium ion homeostasis (GO:0055075)3.60335587
50axon cargo transport (GO:0008088)3.56243622
51neurotransmitter transport (GO:0006836)3.55222806
52acidic amino acid transport (GO:0015800)3.52462063
53regulation of glutamate receptor signaling pathway (GO:1900449)3.51959884
54regulation of dendritic spine morphogenesis (GO:0061001)3.51593772
55cerebellar Purkinje cell differentiation (GO:0021702)3.48267245
56neuromuscular synaptic transmission (GO:0007274)3.46304823
57auditory behavior (GO:0031223)3.43965344
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.41875291
59negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.41850415
60activation of protein kinase A activity (GO:0034199)3.41717074
61positive regulation of neurotransmitter transport (GO:0051590)3.39925224
62innervation (GO:0060384)3.39349841
63regulation of vesicle fusion (GO:0031338)3.39302257
64regulation of dendritic spine development (GO:0060998)3.38694299
65long-term memory (GO:0007616)3.38639660
66regulation of neurotransmitter levels (GO:0001505)3.38409880
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36561692
68positive regulation of neurotransmitter secretion (GO:0001956)3.35302402
69cell differentiation in hindbrain (GO:0021533)3.35043283
70dendritic spine organization (GO:0097061)3.34516728
71cellular sodium ion homeostasis (GO:0006883)3.33449696
72potassium ion import (GO:0010107)3.31226289
73positive regulation of fibroblast migration (GO:0010763)3.31039766
74regulation of ARF protein signal transduction (GO:0032012)3.26607726
75regulation of synaptic transmission (GO:0050804)3.26267438
76membrane depolarization during action potential (GO:0086010)3.22852913
77establishment of mitochondrion localization (GO:0051654)3.21443330
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18732537
79regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.17733929
80L-glutamate transport (GO:0015813)3.17218840
81mitochondrion transport along microtubule (GO:0047497)3.16501600
82establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.16501600
83regulation of synaptic transmission, glutamatergic (GO:0051966)3.15625762
84negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14490439
85long-term synaptic potentiation (GO:0060291)3.13411620
86regulation of neurotransmitter secretion (GO:0046928)3.11578359
87cerebellar Purkinje cell layer development (GO:0021680)3.10340283
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10301707
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.09903676
90energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.08785853
91ATP hydrolysis coupled proton transport (GO:0015991)3.08785853
92negative regulation of calcium ion transport into cytosol (GO:0010523)3.07100521
93regulation of cell communication by electrical coupling (GO:0010649)3.03448864
94response to gravity (GO:0009629)3.01422375
95detection of calcium ion (GO:0005513)2.99805807
96cell communication by electrical coupling (GO:0010644)2.99784104
97regulation of sodium ion transmembrane transporter activity (GO:2000649)2.99203418
98adult walking behavior (GO:0007628)2.98285011
99regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96113813
100regulation of synapse structural plasticity (GO:0051823)2.95427640
101calcium ion-dependent exocytosis (GO:0017156)2.94903896
102regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.94266954
103neuromuscular process controlling balance (GO:0050885)2.93158020
104prepulse inhibition (GO:0060134)2.92429102
105organelle transport along microtubule (GO:0072384)2.92169287
106positive regulation of potassium ion transmembrane transport (GO:1901381)2.90503797
107mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88909423
108synaptic vesicle transport (GO:0048489)2.88805276
109establishment of synaptic vesicle localization (GO:0097480)2.88805276
110neuron recognition (GO:0008038)2.88710392
111synaptic vesicle endocytosis (GO:0048488)2.87372352
112neuron-neuron synaptic transmission (GO:0007270)2.87322319
113synaptic transmission, glutamatergic (GO:0035249)2.87197138
114response to acidic pH (GO:0010447)2.86596693
115regulation of neurotransmitter transport (GO:0051588)2.85522495
116neurotransmitter-gated ion channel clustering (GO:0072578)2.85337884
117ionotropic glutamate receptor signaling pathway (GO:0035235)2.85315120
118neuromuscular process (GO:0050905)2.85043745
119synaptic transmission (GO:0007268)2.84466262
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84312384
121transferrin transport (GO:0033572)2.81318821
122peripheral nervous system neuron development (GO:0048935)2.80765787
123regulation of synaptic plasticity (GO:0048167)2.78076955
124postsynaptic membrane organization (GO:0001941)2.77746294
125layer formation in cerebral cortex (GO:0021819)2.76472161
126regulation of excitatory postsynaptic membrane potential (GO:0060079)2.76368989
127synapse assembly (GO:0007416)2.74611055
128establishment of vesicle localization (GO:0051650)2.74115754
129regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.73895972
130G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.73405329
131regulation of amyloid precursor protein catabolic process (GO:1902991)2.73313213
132membrane depolarization (GO:0051899)2.72414438
133vesicle transport along microtubule (GO:0047496)2.71958032
134axon development (GO:0061564)2.70960230
135regulation of voltage-gated calcium channel activity (GO:1901385)2.70504882
136regulation of postsynaptic membrane potential (GO:0060078)2.70420278
137negative regulation of cation channel activity (GO:2001258)2.68443746
138glutamate receptor signaling pathway (GO:0007215)2.68371940
139neuronal action potential (GO:0019228)2.67719727
140presynaptic membrane assembly (GO:0097105)2.67308711
141transmission of nerve impulse (GO:0019226)2.66744461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57429445
2GBX2_23144817_ChIP-Seq_PC3_Human3.73686896
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.40230310
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.31745251
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.27592186
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.99400417
7REST_21632747_ChIP-Seq_MESCs_Mouse2.90009556
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89884237
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89884237
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72007556
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.67505374
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66973779
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65696164
14TAF15_26573619_Chip-Seq_HEK293_Human2.62376114
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.55013216
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54312205
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.42554697
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33095720
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25300697
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.24352844
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.23361374
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.20226304
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.18817941
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18710886
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18075560
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.10989457
27BMI1_23680149_ChIP-Seq_NPCS_Mouse2.07328280
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02907419
29AR_21572438_ChIP-Seq_LNCaP_Human1.92777577
30DROSHA_22980978_ChIP-Seq_HELA_Human1.89343983
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.88569844
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85622103
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79260934
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68538180
35SMAD4_21799915_ChIP-Seq_A2780_Human1.67847630
36IGF1R_20145208_ChIP-Seq_DFB_Human1.65651957
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61827492
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51670800
39P300_19829295_ChIP-Seq_ESCs_Human1.51372465
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41587763
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41294306
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40134957
43ZNF274_21170338_ChIP-Seq_K562_Hela1.39609668
44* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38768652
45AR_25329375_ChIP-Seq_VCAP_Human1.38094020
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36168215
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35954959
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35097315
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.33989165
50RNF2_27304074_Chip-Seq_NSC_Mouse1.27560456
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26472866
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.26044670
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25286737
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.24048656
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.22850555
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21946552
57* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21268714
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21103232
59* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20646226
60CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.20121168
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17771176
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12579291
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.09777411
64JUN_21703547_ChIP-Seq_K562_Human1.08347046
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.08265059
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.07083965
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06469571
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05876032
69BCAT_22108803_ChIP-Seq_LS180_Human1.04907982
70OCT4_19829295_ChIP-Seq_ESCs_Human1.03617355
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02415613
72STAT3_23295773_ChIP-Seq_U87_Human1.01701636
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01690030
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01682824
75* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01549437
76EGR1_19032775_ChIP-ChIP_M12_Human1.01164630
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99742977
78AR_19668381_ChIP-Seq_PC3_Human0.97859905
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97656371
80* CTCF_27219007_Chip-Seq_Bcells_Human0.96928340
81* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96905185
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96296103
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96198003
84ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95605940
85SMAD3_21741376_ChIP-Seq_ESCs_Human0.94852859
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93953410
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92866099
88GATA1_26923725_Chip-Seq_HPCs_Mouse0.91726595
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91212192
90RUNX2_22187159_ChIP-Seq_PCA_Human0.90332069
91P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90085941
92AHR_22903824_ChIP-Seq_MCF-7_Human0.89946691
93WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89756550
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88669670
95RING1B_27294783_Chip-Seq_NPCs_Mouse0.88455733
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.88286739
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.88218264
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88195044
99* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88121732
100YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87452833
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86931947
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.85077679
103* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84790908
104TCF4_23295773_ChIP-Seq_U87_Human0.84570428
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84506984
106* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84131311
107KDM2B_26808549_Chip-Seq_K562_Human0.83797774
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83701617
109VDR_22108803_ChIP-Seq_LS180_Human0.83428006
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82984089
111* DPY_21335234_ChIP-Seq_ESCs_Mouse0.81253018
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80886085
113KLF4_19829295_ChIP-Seq_ESCs_Human0.80341524
114SMC4_20622854_ChIP-Seq_HELA_Human0.79922102
115KDM2B_26808549_Chip-Seq_REH_Human0.79593058
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79464421
117SMAD_19615063_ChIP-ChIP_OVARY_Human0.79115451
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.79062981
119P68_20966046_ChIP-Seq_HELA_Human0.77737824
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75128828
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.73386578
122LXR_22292898_ChIP-Seq_THP-1_Human0.72532494
123SMAD4_21741376_ChIP-Seq_ESCs_Human0.68854419
124CTCF_20526341_ChIP-Seq_ESCs_Human0.66716901
125MYC_19915707_ChIP-ChIP_AK7_Human0.64882166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.96043121
2MP0003880_abnormal_central_pattern4.49315291
3MP0002735_abnormal_chemical_nociception4.48643138
4MP0004270_analgesia4.29828344
5MP0006276_abnormal_autonomic_nervous3.78364517
6MP0001968_abnormal_touch/_nociception3.66541116
7MP0003635_abnormal_synaptic_transmissio3.49636665
8MP0002736_abnormal_nociception_after3.29979694
9MP0004858_abnormal_nervous_system3.17126417
10MP0002734_abnormal_mechanical_nocicepti3.16145103
11MP0009046_muscle_twitch2.96018901
12MP0009745_abnormal_behavioral_response2.94721710
13MP0002733_abnormal_thermal_nociception2.83642994
14MP0002064_seizures2.78944087
15MP0002063_abnormal_learning/memory/cond2.73127904
16MP0001970_abnormal_pain_threshold2.61821058
17MP0002272_abnormal_nervous_system2.59485327
18MP0002572_abnormal_emotion/affect_behav2.36959993
19MP0002184_abnormal_innervation2.35027733
20MP0002822_catalepsy2.29627036
21MP0001486_abnormal_startle_reflex2.24330741
22MP0003329_amyloid_beta_deposits2.21686181
23MP0002067_abnormal_sensory_capabilities2.12742201
24MP0005423_abnormal_somatic_nervous2.08642020
25MP0004142_abnormal_muscle_tone2.05783674
26MP0001440_abnormal_grooming_behavior1.98706534
27MP0000955_abnormal_spinal_cord1.97161811
28MP0004811_abnormal_neuron_physiology1.84546175
29MP0001529_abnormal_vocalization1.75409236
30MP0008569_lethality_at_weaning1.73902349
31MP0004924_abnormal_behavior1.72843828
32MP0005386_behavior/neurological_phenoty1.72843828
33MP0001501_abnormal_sleep_pattern1.69265395
34MP0001905_abnormal_dopamine_level1.59073466
35MP0002557_abnormal_social/conspecific_i1.56742954
36MP0003879_abnormal_hair_cell1.52820978
37MP0000778_abnormal_nervous_system1.52232048
38MP0000751_myopathy1.49032479
39MP0002751_abnormal_autonomic_nervous1.48362765
40MP0002882_abnormal_neuron_morphology1.47976329
41MP0001984_abnormal_olfaction1.47435230
42MP0002909_abnormal_adrenal_gland1.42799823
43MP0003122_maternal_imprinting1.39255421
44MP0008877_abnormal_DNA_methylation1.37560098
45MP0001986_abnormal_taste_sensitivity1.36170294
46MP0002066_abnormal_motor_capabilities/c1.35805902
47MP0004147_increased_porphyrin_level1.27766094
48MP0003690_abnormal_glial_cell1.26910257
49MP0002229_neurodegeneration1.26573422
50MP0005646_abnormal_pituitary_gland1.24196892
51MP0001348_abnormal_lacrimal_gland1.24104483
52MP0003633_abnormal_nervous_system1.23889975
53MP0010386_abnormal_urinary_bladder1.15947017
54MP0001177_atelectasis1.13701877
55MP0000604_amyloidosis1.11701419
56MP0008872_abnormal_physiological_respon1.11488623
57MP0005551_abnormal_eye_electrophysiolog1.07834822
58MP0001502_abnormal_circadian_rhythm1.07367200
59MP0002752_abnormal_somatic_nervous1.06309620
60MP0003631_nervous_system_phenotype1.05855359
61MP0002837_dystrophic_cardiac_calcinosis1.05733535
62MP0001963_abnormal_hearing_physiology1.04051289
63MP0009780_abnormal_chondrocyte_physiolo1.04008094
64MP0005535_abnormal_body_temperature0.92344463
65MP0004145_abnormal_muscle_electrophysio0.86316629
66MP0005167_abnormal_blood-brain_barrier0.86146245
67MP0003634_abnormal_glial_cell0.85811073
68MP0004885_abnormal_endolymph0.84822020
69MP0001188_hyperpigmentation0.84421575
70MP0004742_abnormal_vestibular_system0.83017600
71MP0005645_abnormal_hypothalamus_physiol0.81848747
72MP0001485_abnormal_pinna_reflex0.80956114
73MP0002638_abnormal_pupillary_reflex0.80468232
74MP0002152_abnormal_brain_morphology0.79564163
75MP0003123_paternal_imprinting0.78180126
76MP0008874_decreased_physiological_sensi0.77710215
77MP0004085_abnormal_heartbeat0.77510845
78MP0000372_irregular_coat_pigmentation0.77440173
79MP0002069_abnormal_eating/drinking_beha0.75945087
80MP0004130_abnormal_muscle_cell0.74852561
81MP0002876_abnormal_thyroid_physiology0.74466218
82MP0002332_abnormal_exercise_endurance0.72887924
83MP0000538_abnormal_urinary_bladder0.70092820
84MP0003121_genomic_imprinting0.69813957
85MP0005623_abnormal_meninges_morphology0.66618329
86MP0003075_altered_response_to0.66600845
87MP0003787_abnormal_imprinting0.65995502
88MP0000534_abnormal_ureter_morphology0.64485459
89MP0003632_abnormal_nervous_system0.63326121
90MP0002653_abnormal_ependyma_morphology0.62337334
91MP0001299_abnormal_eye_distance/0.62312399
92MP0000920_abnormal_myelination0.61500296
93MP0003183_abnormal_peptide_metabolism0.59845905
94MP0000026_abnormal_inner_ear0.59533684
95MP0001943_abnormal_respiration0.59092233
96MP0006072_abnormal_retinal_apoptosis0.58922622
97MP0001664_abnormal_digestion0.57926155
98MP0005499_abnormal_olfactory_system0.57006063
99MP0005394_taste/olfaction_phenotype0.57006063
100MP0000749_muscle_degeneration0.55554840
101MP0006035_abnormal_mitochondrial_morpho0.54831421
102MP0004883_abnormal_blood_vessel0.54620207
103MP0001346_abnormal_lacrimal_gland0.53782975
104MP0004043_abnormal_pH_regulation0.53740278
105MP0004036_abnormal_muscle_relaxation0.52915301
106MP0000747_muscle_weakness0.50802280
107MP0005171_absent_coat_pigmentation0.49603517
108MP0004484_altered_response_of0.48953659
109MP0009379_abnormal_foot_pigmentation0.48804133
110MP0002102_abnormal_ear_morphology0.47473986
111MP0002873_normal_phenotype0.46591318
112MP0010768_mortality/aging0.46542139
113MP0003137_abnormal_impulse_conducting0.45893344
114MP0003956_abnormal_body_size0.45679324
115MP0002082_postnatal_lethality0.45412728
116MP0002169_no_abnormal_phenotype0.45214845
117MP0010769_abnormal_survival0.45049933
118MP0010770_preweaning_lethality0.44379563
119MP0005253_abnormal_eye_physiology0.43258276
120MP0002083_premature_death0.41481446

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.51286034
2Ulnar claw (HP:0001178)6.34510670
3Focal motor seizures (HP:0011153)6.03663534
4Atonic seizures (HP:0010819)5.00961340
5Abnormality of binocular vision (HP:0011514)4.92867847
6Diplopia (HP:0000651)4.92867847
7Action tremor (HP:0002345)4.72247044
8Focal seizures (HP:0007359)4.71964641
9Febrile seizures (HP:0002373)4.49998392
10Pheochromocytoma (HP:0002666)4.29758838
11Supranuclear gaze palsy (HP:0000605)4.15519590
12Visual hallucinations (HP:0002367)4.09535924
13Progressive cerebellar ataxia (HP:0002073)4.04227468
14Neuroendocrine neoplasm (HP:0100634)3.92178845
15Epileptic encephalopathy (HP:0200134)3.80703304
16Intention tremor (HP:0002080)3.61985008
17Absence seizures (HP:0002121)3.61329657
18Hypothermia (HP:0002045)3.54071317
19Generalized tonic-clonic seizures (HP:0002069)3.32412029
20Termporal pattern (HP:0011008)3.31695444
21Insidious onset (HP:0003587)3.31695444
22Dialeptic seizures (HP:0011146)3.23023349
23Failure to thrive in infancy (HP:0001531)3.22093201
24Neurofibrillary tangles (HP:0002185)3.22003375
25Status epilepticus (HP:0002133)3.19730829
26Amblyopia (HP:0000646)3.17041433
27Ankle clonus (HP:0011448)3.09353947
28Poor suck (HP:0002033)3.02622516
29Papilledema (HP:0001085)3.02356549
30Hemiplegia (HP:0002301)2.94974148
31Abnormal eating behavior (HP:0100738)2.92910662
32Foot dorsiflexor weakness (HP:0009027)2.91055350
33Peripheral hypomyelination (HP:0007182)2.88289331
34Cerebral hypomyelination (HP:0006808)2.87385740
35Tetraplegia (HP:0002445)2.86983039
36Acute necrotizing encephalopathy (HP:0006965)2.86732395
37Segmental peripheral demyelination/remyelination (HP:0003481)2.81722640
38Steppage gait (HP:0003376)2.80227004
39Anxiety (HP:0000739)2.77322456
40Hammertoe (HP:0001765)2.75927186
41Impaired vibration sensation in the lower limbs (HP:0002166)2.74579683
42Hypoventilation (HP:0002791)2.73900274
43Delusions (HP:0000746)2.73705299
44Annular pancreas (HP:0001734)2.72912442
45Urinary urgency (HP:0000012)2.71662725
46Myotonia (HP:0002486)2.71004149
47Urinary bladder sphincter dysfunction (HP:0002839)2.69082426
48Neuronal loss in central nervous system (HP:0002529)2.68495015
49Impaired pain sensation (HP:0007328)2.67025539
50Abnormality of pain sensation (HP:0010832)2.67025539
51Spastic gait (HP:0002064)2.66961791
52Abnormal mitochondria in muscle tissue (HP:0008316)2.63167162
53Truncal ataxia (HP:0002078)2.60970254
54Abnormality of the foot musculature (HP:0001436)2.59679339
55Impaired smooth pursuit (HP:0007772)2.59607961
56Neoplasm of the peripheral nervous system (HP:0100007)2.58071870
57Hemiparesis (HP:0001269)2.56293843
58Limb dystonia (HP:0002451)2.56096294
59Depression (HP:0000716)2.55177463
60Progressive macrocephaly (HP:0004481)2.54914452
61Abnormal hair whorl (HP:0010721)2.53298347
62Clonus (HP:0002169)2.52661769
63Fetal akinesia sequence (HP:0001989)2.52187086
64Abnormality of the corticospinal tract (HP:0002492)2.52132111
65Polyphagia (HP:0002591)2.51487240
66Hypsarrhythmia (HP:0002521)2.46330638
67Mitochondrial inheritance (HP:0001427)2.45654617
68Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.43665808
69Amyotrophic lateral sclerosis (HP:0007354)2.37696641
70Cerebral inclusion bodies (HP:0100314)2.37641221
71Apathy (HP:0000741)2.37507448
72Abnormality of the vocal cords (HP:0008777)2.37346976
73Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.37189628
74Hypercortisolism (HP:0001578)2.30973084
75Scanning speech (HP:0002168)2.30438246
76Morphological abnormality of the pyramidal tract (HP:0002062)2.29297320
77Ventricular fibrillation (HP:0001663)2.28408747
78Dysmetria (HP:0001310)2.27723685
79Sleep apnea (HP:0010535)2.25912300
80Distal sensory impairment (HP:0002936)2.25441397
81Gaze-evoked nystagmus (HP:0000640)2.22688358
82Diminished motivation (HP:0000745)2.22271669
83Acute encephalopathy (HP:0006846)2.20503215
84Progressive inability to walk (HP:0002505)2.19014490
85Abnormality of the lower motor neuron (HP:0002366)2.18718209
86Aplasia/Hypoplasia of the brainstem (HP:0007362)2.16971838
87Hypoplasia of the brainstem (HP:0002365)2.16971838
88Abnormality of ocular smooth pursuit (HP:0000617)2.16050700
89Decreased motor nerve conduction velocity (HP:0003431)2.12928921
90Incomplete penetrance (HP:0003829)2.11379819
91Bradykinesia (HP:0002067)2.10860623
92Akinesia (HP:0002304)2.10820376
93Oligomenorrhea (HP:0000876)2.10215987
94Hyperventilation (HP:0002883)2.10065276
95Hepatocellular necrosis (HP:0001404)2.07621170
96Dysdiadochokinesis (HP:0002075)2.06728411
97Increased CSF lactate (HP:0002490)2.06499988
98Rigidity (HP:0002063)2.05713833
99Abnormality of saccadic eye movements (HP:0000570)2.05220218
100Generalized hypotonia (HP:0001290)2.03699135
101Torticollis (HP:0000473)2.01927331
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01483905
103Degeneration of the lateral corticospinal tracts (HP:0002314)2.01483905
104Narrow nasal bridge (HP:0000446)1.98673363
105CNS hypomyelination (HP:0003429)1.98646651
106Retinal dysplasia (HP:0007973)1.97575799
107Lower limb muscle weakness (HP:0007340)1.97492448
108Dysmetric saccades (HP:0000641)1.97229122
109Postural instability (HP:0002172)1.96782995
110Broad-based gait (HP:0002136)1.96559331
111Gait imbalance (HP:0002141)1.96306788
112Bradycardia (HP:0001662)1.96229944
113Mutism (HP:0002300)1.94704944
114Muscle stiffness (HP:0003552)1.92273643
115Poor eye contact (HP:0000817)1.91896123
116Spastic tetraparesis (HP:0001285)1.91590769
117Focal dystonia (HP:0004373)1.91466306
118Epileptiform EEG discharges (HP:0011182)1.90620217
119Abnormal social behavior (HP:0012433)1.90200682
120Impaired social interactions (HP:0000735)1.90200682
121Inability to walk (HP:0002540)1.88974495
122Gait ataxia (HP:0002066)1.88749878
123Split foot (HP:0001839)1.88675722
124Drooling (HP:0002307)1.87372928
125Emotional lability (HP:0000712)1.86870666
126Craniofacial dystonia (HP:0012179)1.85203675
127Impaired vibratory sensation (HP:0002495)1.85102243
128Autoamputation (HP:0001218)1.85082592
129Obstructive sleep apnea (HP:0002870)1.84552760
130EEG with generalized epileptiform discharges (HP:0011198)1.82988380
131Choreoathetosis (HP:0001266)1.82813133
132Slow saccadic eye movements (HP:0000514)1.82809198
133Specific learning disability (HP:0001328)1.81941494
134Onion bulb formation (HP:0003383)1.80910468
135Rapidly progressive (HP:0003678)1.80742720
136Memory impairment (HP:0002354)1.80595366
137Spastic tetraplegia (HP:0002510)1.80340052
138Increased circulating renin level (HP:0000848)1.77027088
139Bundle branch block (HP:0011710)1.76885823
140Excessive salivation (HP:0003781)1.75956554
141Stereotypic behavior (HP:0000733)1.73111130
142Insomnia (HP:0100785)1.72122633
143Absent speech (HP:0001344)1.70194673
144Genetic anticipation (HP:0003743)1.69320551
145Abnormal EKG (HP:0003115)1.67655672
146Spinal canal stenosis (HP:0003416)1.65490686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MINK14.26523045
2NTRK34.23128563
3MAP3K123.80747970
4CASK3.25100965
5LMTK23.24701951
6MAP3K43.06605168
7MAP3K93.02788551
8MAP2K72.73623648
9MARK12.56206516
10NTRK12.50636211
11MAP2K42.41757035
12LATS22.21631186
13GRK51.91826203
14KSR21.81579315
15PHKG11.77829576
16PHKG21.77829576
17EPHA41.76830957
18CDK191.75380066
19PAK61.72491164
20MAPKAPK31.69613298
21LIMK11.68189549
22DAPK21.66550271
23MAPK131.64211384
24ARAF1.53507825
25PLK21.49058127
26GRK71.42751947
27SIK31.37774278
28TXK1.33663639
29CAMKK11.30381186
30CAMKK21.27608756
31CDK51.26655612
32PRKCG1.22669277
33ADRBK11.20990503
34MAP2K21.20304316
35DAPK11.18500745
36NTRK21.10878754
37SCYL21.05203903
38KSR11.02289651
39WNK11.01903018
40TESK11.01791405
41NEK61.01257241
42RET0.99198918
43MAP3K20.97980773
44TYRO30.97837090
45MAP2K10.97435053
46DYRK1A0.97380226
47BMPR20.94543466
48TAOK30.94148856
49MARK20.93688594
50PNCK0.89462050
51MAPK120.89232431
52CAMK2A0.88991398
53UHMK10.88087460
54NEK10.85705608
55MAP3K110.85021160
56PKN10.84853287
57NME10.84470909
58SGK4940.82774183
59SGK2230.82774183
60FER0.81859037
61MATK0.81194980
62OXSR10.80335642
63ALK0.78070988
64STK390.77976870
65CDK180.77325862
66CDK140.76414862
67ADRBK20.76306865
68CAMK2G0.76053784
69WNK40.74739862
70RIPK40.73541558
71STK380.71895229
72BCR0.70670069
73TNK20.70469203
74CDK150.68710846
75GRK60.66499674
76SGK20.65657041
77CAMK40.64569993
78PTK2B0.64337458
79BRSK10.62623149
80CSNK1G20.62039062
81FYN0.61094591
82SIK20.61010797
83MAP3K130.60502085
84SGK10.60077482
85PAK30.60026054
86PRPF4B0.59568727
87RPS6KA30.59153036
88CDK11A0.59109841
89TNIK0.59079699
90MAPK100.57801091
91TESK20.57241751
92PRKCE0.55724021
93MAP3K10.54640747
94RPS6KA20.54628809
95FES0.51347833
96PDK40.49350394
97PDK30.49350394
98PDPK10.49046536
99CAMK2B0.47801037
100PRKCH0.47223988
101PRKCA0.46572039
102ROCK20.44517168
103MAPK40.43550434
104PDK10.43031641
105PINK10.42791975
106JAK10.40907662
107CAMK10.40539049
108DAPK30.40440204
109DYRK20.39266517
110MAP2K60.38752868
111TAOK10.38691661
112CCNB10.38273322
113CAMK2D0.38131467
114SGK30.37919066
115BRAF0.37198930
116CSNK1G30.37131051
117CSNK1A10.36069596
118PRKCZ0.35991591
119PRKD30.35970603
120CSNK1E0.35933967
121MUSK0.35083950
122PRKACA0.34875838
123PRKG20.34809362
124CSNK1A1L0.34678187
125AKT30.33625127
126PRKG10.32600056
127STK110.32265331
128RAF10.32242200
129MYLK0.31785975
130CSNK1D0.31106317
131PRKCB0.29240572
132SRC0.29138615
133MAPK80.28985731

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.47536812
2Nicotine addiction_Homo sapiens_hsa050332.84753452
3Olfactory transduction_Homo sapiens_hsa047402.70832200
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.69490707
5Oxidative phosphorylation_Homo sapiens_hsa001902.69250564
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.65204309
7Collecting duct acid secretion_Homo sapiens_hsa049662.49805936
8Parkinsons disease_Homo sapiens_hsa050122.31881264
9Long-term potentiation_Homo sapiens_hsa047202.22400170
10Circadian entrainment_Homo sapiens_hsa047132.13840748
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10322168
12Dopaminergic synapse_Homo sapiens_hsa047282.06914418
13Amphetamine addiction_Homo sapiens_hsa050312.05495271
14Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.01129388
15Cholinergic synapse_Homo sapiens_hsa047251.98830465
16Alzheimers disease_Homo sapiens_hsa050101.96311926
17GABAergic synapse_Homo sapiens_hsa047271.90502680
18Taste transduction_Homo sapiens_hsa047421.81012492
19Glutamatergic synapse_Homo sapiens_hsa047241.79272865
20Insulin secretion_Homo sapiens_hsa049111.77951440
21Cardiac muscle contraction_Homo sapiens_hsa042601.68803735
22Salivary secretion_Homo sapiens_hsa049701.67788901
23Morphine addiction_Homo sapiens_hsa050321.67700699
24Vibrio cholerae infection_Homo sapiens_hsa051101.60056738
25Gastric acid secretion_Homo sapiens_hsa049711.59987909
26Huntingtons disease_Homo sapiens_hsa050161.55815501
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55050016
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54353894
29Serotonergic synapse_Homo sapiens_hsa047261.52890024
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.48775041
31Renin secretion_Homo sapiens_hsa049241.40947646
32Calcium signaling pathway_Homo sapiens_hsa040201.33708599
33GnRH signaling pathway_Homo sapiens_hsa049121.33705323
34Oxytocin signaling pathway_Homo sapiens_hsa049211.30602098
35Gap junction_Homo sapiens_hsa045401.29420146
36Cocaine addiction_Homo sapiens_hsa050301.25907157
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24958351
38Long-term depression_Homo sapiens_hsa047301.17423562
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11443263
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09726577
41Vitamin B6 metabolism_Homo sapiens_hsa007501.07878518
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03571836
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02059727
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00644113
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98819896
46Oocyte meiosis_Homo sapiens_hsa041140.95776096
47Axon guidance_Homo sapiens_hsa043600.93112425
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91323968
49ErbB signaling pathway_Homo sapiens_hsa040120.90820838
50Glioma_Homo sapiens_hsa052140.88431562
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.86831043
52cAMP signaling pathway_Homo sapiens_hsa040240.86382961
53Melanogenesis_Homo sapiens_hsa049160.86082196
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82988699
55Estrogen signaling pathway_Homo sapiens_hsa049150.81581737
56Phototransduction_Homo sapiens_hsa047440.78122473
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76246637
58Dorso-ventral axis formation_Homo sapiens_hsa043200.75067475
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74675773
60Phagosome_Homo sapiens_hsa041450.74009569
61Glucagon signaling pathway_Homo sapiens_hsa049220.73844290
62Nitrogen metabolism_Homo sapiens_hsa009100.73086834
63Pyruvate metabolism_Homo sapiens_hsa006200.72543360
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.67683955
65Type II diabetes mellitus_Homo sapiens_hsa049300.66568060
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64143260
67Insulin signaling pathway_Homo sapiens_hsa049100.61144983
68Circadian rhythm_Homo sapiens_hsa047100.60523302
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56815886
70VEGF signaling pathway_Homo sapiens_hsa043700.54881053
71MAPK signaling pathway_Homo sapiens_hsa040100.54617585
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54301585
73Rheumatoid arthritis_Homo sapiens_hsa053230.53305482
74Prion diseases_Homo sapiens_hsa050200.52762615
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52474610
76Endocytosis_Homo sapiens_hsa041440.51010713
77Ras signaling pathway_Homo sapiens_hsa040140.49182054
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.47590797
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.47176348
80Thyroid hormone synthesis_Homo sapiens_hsa049180.46663938
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45429710
82Pancreatic secretion_Homo sapiens_hsa049720.44848424
83Choline metabolism in cancer_Homo sapiens_hsa052310.43741790
84Salmonella infection_Homo sapiens_hsa051320.43296853
85Dilated cardiomyopathy_Homo sapiens_hsa054140.42660455
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38892820
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37529464
88Inositol phosphate metabolism_Homo sapiens_hsa005620.37117347
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37027095
90Rap1 signaling pathway_Homo sapiens_hsa040150.36825172
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.36418721
92Melanoma_Homo sapiens_hsa052180.34045225
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33701128
94Regulation of autophagy_Homo sapiens_hsa041400.33070816
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32871716
96Bile secretion_Homo sapiens_hsa049760.31030554
97Alcoholism_Homo sapiens_hsa050340.30744196
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27732536
99Arginine and proline metabolism_Homo sapiens_hsa003300.27412307
100Thyroid cancer_Homo sapiens_hsa052160.27210272
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26425967
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25061718
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24209237
104Phenylalanine metabolism_Homo sapiens_hsa003600.23196866
105Histidine metabolism_Homo sapiens_hsa003400.23178382
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22789996
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22540741
108Prolactin signaling pathway_Homo sapiens_hsa049170.22372841
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.20908056
110Wnt signaling pathway_Homo sapiens_hsa043100.20550466
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20453330
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20243523
113Chemokine signaling pathway_Homo sapiens_hsa040620.18838974
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18481977
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17627563
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15645970
117Mineral absorption_Homo sapiens_hsa049780.14623964
118beta-Alanine metabolism_Homo sapiens_hsa004100.11941310
119T cell receptor signaling pathway_Homo sapiens_hsa046600.08776037
120Ether lipid metabolism_Homo sapiens_hsa005650.07913529

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