FYCO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)5.92405157
2doxorubicin metabolic process (GO:0044598)5.92405157
3daunorubicin metabolic process (GO:0044597)5.92405157
4cardiac myofibril assembly (GO:0055003)5.39571098
5regulation of skeletal muscle contraction (GO:0014819)5.34795888
6sarcomere organization (GO:0045214)5.20702203
7myofibril assembly (GO:0030239)5.18528301
8regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.01050151
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.99395769
10response to inactivity (GO:0014854)4.98388182
11response to muscle activity (GO:0014850)4.96645810
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.90854812
13muscle filament sliding (GO:0030049)4.71939354
14actin-myosin filament sliding (GO:0033275)4.71939354
15NADH metabolic process (GO:0006734)4.67299103
16negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.57667513
17sarcoplasmic reticulum calcium ion transport (GO:0070296)4.52258978
18regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.47672442
19carnitine shuttle (GO:0006853)4.39728549
20skeletal muscle fiber development (GO:0048741)4.20345159
21plasma membrane repair (GO:0001778)4.15401678
22actin-mediated cell contraction (GO:0070252)4.10502406
23cardiac muscle contraction (GO:0060048)4.06790700
24negative regulation of potassium ion transmembrane transport (GO:1901380)4.06243285
25regulation of cell communication by electrical coupling (GO:0010649)4.03464670
26regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.99892997
27fatty acid transmembrane transport (GO:1902001)3.96908990
28glucan catabolic process (GO:0009251)3.95925331
29regulation of relaxation of muscle (GO:1901077)3.88881985
30cardiac muscle hypertrophy (GO:0003300)3.87230807
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84122440
32skeletal muscle tissue development (GO:0007519)3.81408311
33myotube cell development (GO:0014904)3.80721351
34regulation of sarcomere organization (GO:0060297)3.77945405
35ventricular cardiac muscle cell action potential (GO:0086005)3.76802265
36striated muscle contraction (GO:0006941)3.73963488
37cellular polysaccharide catabolic process (GO:0044247)3.73775470
38striated muscle hypertrophy (GO:0014897)3.71907936
39aminoglycoside antibiotic metabolic process (GO:0030647)3.65146286
40regulation of actin filament-based movement (GO:1903115)3.63909781
41regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.62486316
42glycogen biosynthetic process (GO:0005978)3.62107487
43glucan biosynthetic process (GO:0009250)3.62107487
44bundle of His cell to Purkinje myocyte communication (GO:0086069)3.61174219
45actomyosin structure organization (GO:0031032)3.61003542
46adult heart development (GO:0007512)3.55446841
47actin filament-based movement (GO:0030048)3.52488407
48regulation of membrane repolarization (GO:0060306)3.52438717
49regulation of striated muscle contraction (GO:0006942)3.49408431
50regulation of sequestering of triglyceride (GO:0010889)3.47613919
51positive regulation of myotube differentiation (GO:0010831)3.47181191
52muscle fiber development (GO:0048747)3.46661697
53regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.45154500
54cell communication involved in cardiac conduction (GO:0086065)3.44360090
55carnitine transmembrane transport (GO:1902603)3.38947387
56cardiac muscle cell development (GO:0055013)3.35083696
57polysaccharide catabolic process (GO:0000272)3.33504255
58heart contraction (GO:0060047)3.31939556
59heart process (GO:0003015)3.31939556
60response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.31292794
61muscle hypertrophy (GO:0014896)3.29289741
62relaxation of cardiac muscle (GO:0055119)3.27247862
63skeletal muscle contraction (GO:0003009)3.23359090
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22227703
65muscle adaptation (GO:0043500)3.21018679
66muscle cell cellular homeostasis (GO:0046716)3.18566913
67skeletal muscle adaptation (GO:0043501)3.18337048
68cell communication by electrical coupling (GO:0010644)3.18325255
69regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.16323274
70cardiac cell development (GO:0055006)3.15379207
71positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.14996835
72cardiac muscle cell action potential (GO:0086001)3.12155870
73carnitine transport (GO:0015879)3.10121993
74amino-acid betaine transport (GO:0015838)3.10121993
75glycogen metabolic process (GO:0005977)3.05686024
76muscle organ development (GO:0007517)3.05631670
77myoblast fusion (GO:0007520)3.04893756
78muscle structure development (GO:0061061)3.03317721
79positive regulation of glycolytic process (GO:0045821)3.02596757
80cardiac conduction (GO:0061337)3.00533651
81cellular glucan metabolic process (GO:0006073)3.00230950
82glucan metabolic process (GO:0044042)3.00230950
83muscle cell fate commitment (GO:0042693)2.99951794
84regulation of cardiac muscle contraction (GO:0055117)2.99544572
85cardiac muscle tissue morphogenesis (GO:0055008)2.99438190
86striated muscle cell development (GO:0055002)2.98874895
87positive regulation of cation channel activity (GO:2001259)2.97397256
88response to epinephrine (GO:0071871)2.95830705
89negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95418323
90cardiac muscle cell action potential involved in contraction (GO:0086002)2.95202112
91regulation of the force of heart contraction (GO:0002026)2.94923688
92negative regulation of protein localization to cell surface (GO:2000009)2.93462417
93tricarboxylic acid cycle (GO:0006099)2.90578422
94striated muscle tissue development (GO:0014706)2.87550994
95cellular response to epinephrine stimulus (GO:0071872)2.87223911
96regulation of muscle system process (GO:0090257)2.87008477
97focal adhesion assembly (GO:0048041)2.85794373
98cell-substrate adherens junction assembly (GO:0007045)2.85794373
99desmosome organization (GO:0002934)2.85702961
100negative regulation of necroptotic process (GO:0060546)2.85692113
101relaxation of muscle (GO:0090075)2.85052193
102syncytium formation by plasma membrane fusion (GO:0000768)2.83364581
103fructose metabolic process (GO:0006000)2.83060535
104regulation of myoblast differentiation (GO:0045661)2.82243841
105regulation of acyl-CoA biosynthetic process (GO:0050812)2.81846670
106skeletal muscle tissue regeneration (GO:0043403)2.81508314
107neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.80259537
108detection of calcium ion (GO:0005513)2.79863352
109response to pheromone (GO:0019236)2.79319631
110striated muscle adaptation (GO:0014888)2.78819461
111cardiac muscle adaptation (GO:0014887)2.77425867
112cardiac muscle hypertrophy in response to stress (GO:0014898)2.77425867
113muscle hypertrophy in response to stress (GO:0003299)2.77425867
114regulation of heart rate by cardiac conduction (GO:0086091)2.76527386
1152-oxoglutarate metabolic process (GO:0006103)2.75153471
116striated muscle atrophy (GO:0014891)2.73544534
117muscle tissue morphogenesis (GO:0060415)2.72832651
118detection of molecule of bacterial origin (GO:0032490)2.72519048
119regulation of calcium ion transmembrane transporter activity (GO:1901019)2.72421904
120regulation of calcium ion transmembrane transport (GO:1903169)2.72421904
121ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.71174004
122potassium ion import (GO:0010107)2.70817140
123venous blood vessel morphogenesis (GO:0048845)2.70407635
124muscle contraction (GO:0006936)2.70207372
125regulation of heart rate (GO:0002027)2.69448206
126positive regulation of vascular permeability (GO:0043117)2.64022579
127regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.62131264
128muscle system process (GO:0003012)2.58502974
129regulation of fatty acid oxidation (GO:0046320)2.55894974
130regulation of heart contraction (GO:0008016)2.55094651
131glycogen catabolic process (GO:0005980)2.50981193
132negative regulation of potassium ion transport (GO:0043267)2.50913047
133intracellular lipid transport (GO:0032365)2.50878781
134creatine metabolic process (GO:0006600)2.48656302
135heart trabecula formation (GO:0060347)2.48419511
136pyrimidine ribonucleoside catabolic process (GO:0046133)2.48323297
137regulation of cardiac muscle cell contraction (GO:0086004)2.48023398
138positive regulation of heart rate (GO:0010460)2.46719281
139muscle atrophy (GO:0014889)2.43974770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.40972198
2RARG_19884340_ChIP-ChIP_MEFs_Mouse2.75820388
3GBX2_23144817_ChIP-Seq_PC3_Human2.45115031
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.37435590
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36973936
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.32784731
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.29644099
8DROSHA_22980978_ChIP-Seq_HELA_Human2.11087786
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09305926
10CLOCK_20551151_ChIP-Seq_293T_Human1.95806626
11* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92933720
12BP1_19119308_ChIP-ChIP_Hs578T_Human1.88888873
13TP63_17297297_ChIP-ChIP_HaCaT_Human1.87940696
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86241327
15MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.84122599
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81859833
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.81113957
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.77355245
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66602364
20TBX20_22080862_ChIP-Seq_HEART_Mouse1.63568329
21TBX20_22328084_ChIP-Seq_HEART_Mouse1.63568329
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.62137317
23NFIB_24661679_ChIP-Seq_LUNG_Mouse1.60860573
24* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.60089256
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58354672
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57805216
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57014352
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52039547
29ZNF263_19887448_ChIP-Seq_K562_Human1.50368878
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49919280
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49764957
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48900086
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48244351
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47498621
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44139669
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42544518
37GATA4_21415370_ChIP-Seq_HL-1_Mouse1.40487419
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37235238
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37235238
40SMAD4_21799915_ChIP-Seq_A2780_Human1.36085917
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36059737
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.33801245
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32050169
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31023157
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30645252
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28741084
47PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28600102
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28295242
49TCF7_22412390_ChIP-Seq_EML_Mouse1.27940113
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27810353
51RACK7_27058665_Chip-Seq_MCF-7_Human1.27579448
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.25100657
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.23959621
54SMAD3_21741376_ChIP-Seq_HESCs_Human1.21684510
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21115434
56* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20311322
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18612550
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18221134
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17493486
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16929114
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16013552
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.15979516
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.15798867
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15586487
65STAT3_23295773_ChIP-Seq_U87_Human1.15498840
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15440401
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14609994
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14205322
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13988072
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13716971
71* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13507714
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13353443
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.13268417
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11506569
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11506569
76EED_16625203_ChIP-ChIP_MESCs_Mouse1.11496391
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.11446573
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11109232
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10598670
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.10124499
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09964176
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09895300
83KDM2B_26808549_Chip-Seq_DND41_Human1.09825734
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09764357
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.09664210
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09211118
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.09092658
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.09021355
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08825428
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08337492
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08317407
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08272786
93PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08204744
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08118182
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08086353
96TP53_16413492_ChIP-PET_HCT116_Human1.07537106
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07504901
98TCF4_23295773_ChIP-Seq_U87_Human1.06636984
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06462253
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06280848
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05332695
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05332695
103BCAT_22108803_ChIP-Seq_LS180_Human1.05016193
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04994310
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04968178
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04605690
107JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04405072
108* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04332161
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.04152278
110RXR_22158963_ChIP-Seq_LIVER_Mouse1.04107189
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.03854437
112AHR_22903824_ChIP-Seq_MCF-7_Human1.03713930
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03172452
114TBL1_22424771_ChIP-Seq_293T_Human1.03010266
115SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02867859
116RXR_22108803_ChIP-Seq_LS180_Human1.02261836
117AR_25329375_ChIP-Seq_VCAP_Human1.01710645
118CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00607740
119AR_21572438_ChIP-Seq_LNCaP_Human1.00348257
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99919226
121* AR_19668381_ChIP-Seq_PC3_Human0.99895046
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99687035
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98518755
124SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98197721
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97233468
126GATA1_22025678_ChIP-Seq_K562_Human0.96865054
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.96250068
128TCF4_18268006_ChIP-ChIP_LS174T_Human0.96084138
129LXR_22292898_ChIP-Seq_THP-1_Human0.96072523
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96027655
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96027655
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95448597
133VDR_24787735_ChIP-Seq_THP-1_Human0.94751700
134P300_19829295_ChIP-Seq_ESCs_Human0.94432796
135CJUN_26792858_Chip-Seq_BT549_Human0.94263782
136NFE2_27457419_Chip-Seq_LIVER_Mouse0.94234876
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93805960
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93298027
139KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92719708
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92589534
141WT1_19549856_ChIP-ChIP_CCG9911_Human0.91826868
142GATA1_19941826_ChIP-Seq_K562_Human0.91318021
143ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91146539
144SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91137966
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91124209
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90553395
147EZH2_27294783_Chip-Seq_NPCs_Mouse0.90233190
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89854646
149CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89517075
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89322448
151E2F1_18555785_Chip-Seq_ESCs_Mouse0.89280249
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88913433
153ISL1_27105846_Chip-Seq_CPCs_Mouse0.88793409
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88383881
155* RUNX_20019798_ChIP-Seq_JUKART_Human0.87497332
156P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87172950
157GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86887685
158GATA2_19941826_ChIP-Seq_K562_Human0.86541685
159FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86508517
160TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86256973
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.86200768
162AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85356694
163TP53_23651856_ChIP-Seq_MEFs_Mouse0.85242609
164CBP_20019798_ChIP-Seq_JUKART_Human0.85211207
165RUNX1_27514584_Chip-Seq_MCF-7_Human0.84442669
166STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84120431
167DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82544899
168BRD4_25478319_ChIP-Seq_HGPS_Human0.82373055
169UBF1/2_26484160_Chip-Seq_HMECs_Human0.80653821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.88422268
2MP0002837_dystrophic_cardiac_calcinosis5.53971124
3MP0000751_myopathy4.41194487
4MP0004084_abnormal_cardiac_muscle4.37666089
5MP0004215_abnormal_myocardial_fiber4.00754813
6MP0004036_abnormal_muscle_relaxation3.75398188
7MP0000749_muscle_degeneration3.67034305
8MP0005330_cardiomyopathy2.92205591
9MP0004130_abnormal_muscle_cell2.84353455
10MP0004145_abnormal_muscle_electrophysio2.73245023
11MP0005670_abnormal_white_adipose2.72374768
12MP0004087_abnormal_muscle_fiber2.62545123
13MP0005620_abnormal_muscle_contractility2.57729517
14MP0008775_abnormal_heart_ventricle2.52777831
15MP0002972_abnormal_cardiac_muscle2.49732212
16MP0004484_altered_response_of2.33207942
17MP0002106_abnormal_muscle_physiology2.28730200
18MP0003137_abnormal_impulse_conducting2.21208274
19MP0003950_abnormal_plasma_membrane2.12943034
20MP0004510_myositis2.12469261
21MP0000750_abnormal_muscle_regeneration2.07652430
22MP0005666_abnormal_adipose_tissue2.05586552
23MP0010630_abnormal_cardiac_muscle1.97762538
24MP0004085_abnormal_heartbeat1.97732042
25MP0002269_muscular_atrophy1.95718716
26MP0000759_abnormal_skeletal_muscle1.89800603
27MP0005369_muscle_phenotype1.88498054
28MP0008438_abnormal_cutaneous_collagen1.87207682
29MP0001544_abnormal_cardiovascular_syste1.86188144
30MP0005385_cardiovascular_system_phenoty1.86188144
31MP0000013_abnormal_adipose_tissue1.85654509
32MP0005551_abnormal_eye_electrophysiolog1.83975136
33MP0006138_congestive_heart_failure1.79772423
34MP0004185_abnormal_adipocyte_glucose1.76239204
35MP0004233_abnormal_muscle_weight1.74267005
36MP0003705_abnormal_hypodermis_morpholog1.67440416
37MP0003828_pulmonary_edema1.67218228
38MP0000747_muscle_weakness1.63170278
39MP0008004_abnormal_stomach_pH1.60605351
40MP0005275_abnormal_skin_tensile1.55150896
41MP0002127_abnormal_cardiovascular_syste1.55020581
42MP0003045_fibrosis1.48503284
43MP0001661_extended_life_span1.46307129
44MP0005377_hearing/vestibular/ear_phenot1.32781305
45MP0003878_abnormal_ear_physiology1.32781305
46MP0005375_adipose_tissue_phenotype1.29903563
47MP0005365_abnormal_bile_salt1.29873230
48MP0010368_abnormal_lymphatic_system1.21694450
49MP0002332_abnormal_exercise_endurance1.17401856
50MP0002971_abnormal_brown_adipose1.15222444
51MP0005085_abnormal_gallbladder_physiolo1.12153854
52MP0002108_abnormal_muscle_morphology1.10021789
53MP0001958_emphysema1.09961505
54MP0003252_abnormal_bile_duct1.06461466
55MP0005503_abnormal_tendon_morphology1.03903444
56MP0004272_abnormal_basement_membrane1.02658990
57MP0005266_abnormal_metabolism0.97974897
58MP0009697_abnormal_copulation0.96648269
59MP0008961_abnormal_basal_metabolism0.90680185
60MP0003011_delayed_dark_adaptation0.89875966
61MP0005253_abnormal_eye_physiology0.88467674
62MP0003279_aneurysm0.88094955
63MP0000266_abnormal_heart_morphology0.86478593
64MP0005334_abnormal_fat_pad0.83395554
65MP0000230_abnormal_systemic_arterial0.83012543
66MP0003221_abnormal_cardiomyocyte_apopto0.81156736
67MP0004043_abnormal_pH_regulation0.80230613
68MP0000003_abnormal_adipose_tissue0.79159494
69MP0003091_abnormal_cell_migration0.78743210
70MP0001324_abnormal_eye_pigmentation0.78643095
71MP0002896_abnormal_bone_mineralization0.78283665
72MP0000566_synostosis0.78204410
73MP0000569_abnormal_digit_pigmentation0.77616212
74MP0003868_abnormal_feces_composition0.77089354
75MP0000733_abnormal_muscle_development0.76906892
76MP0001879_abnormal_lymphatic_vessel0.76585838
77MP0002078_abnormal_glucose_homeostasis0.75859730
78MP0009840_abnormal_foam_cell0.75580018
79MP0005409_darkened_coat_color0.72983682
80MP0006072_abnormal_retinal_apoptosis0.72623059
81MP0010329_abnormal_lipoprotein_level0.71477958
82MP0002090_abnormal_vision0.71143211
83MP0002118_abnormal_lipid_homeostasis0.70602005
84MP0001502_abnormal_circadian_rhythm0.70346632
85MP0003191_abnormal_cellular_cholesterol0.69656414
86MP0003879_abnormal_hair_cell0.68683534
87MP0009115_abnormal_fat_cell0.67957269
88MP0005165_increased_susceptibility_to0.66868244
89MP0003656_abnormal_erythrocyte_physiolo0.65990946
90MP0002128_abnormal_blood_circulation0.63867603
91MP0002234_abnormal_pharynx_morphology0.63381996
92MP0000343_altered_response_to0.62383482
93MP0005257_abnormal_intraocular_pressure0.61774450
94MP0004859_abnormal_synaptic_plasticity0.60893888
95MP0002877_abnormal_melanocyte_morpholog0.60243937
96MP0005023_abnormal_wound_healing0.60227697
97MP0005195_abnormal_posterior_eye0.59534103
98MP0006036_abnormal_mitochondrial_physio0.58614753
99MP0001486_abnormal_startle_reflex0.57015613
100MP0005646_abnormal_pituitary_gland0.55471517
101MP0005535_abnormal_body_temperature0.54364556
102MP0000579_abnormal_nail_morphology0.52020696
103MP0008874_decreased_physiological_sensi0.51878942
104MP0002909_abnormal_adrenal_gland0.51305243
105MP0002638_abnormal_pupillary_reflex0.50845312
106MP0000767_abnormal_smooth_muscle0.50756856
107MP0004134_abnormal_chest_morphology0.50699575
108MP0002060_abnormal_skin_morphology0.50537572
109MP0005645_abnormal_hypothalamus_physiol0.50149430
110MP0005319_abnormal_enzyme/_coenzyme0.49970071
111MP0009780_abnormal_chondrocyte_physiolo0.49477780
112MP0003566_abnormal_cell_adhesion0.49027642
113MP0003300_gastrointestinal_ulcer0.48214362
114MP0003941_abnormal_skin_development0.47118337
115MP0010352_gastrointestinal_tract_polyps0.46634210
116MP0005595_abnormal_vascular_smooth0.46083247
117MP0005623_abnormal_meninges_morphology0.45909825
118MP0002998_abnormal_bone_remodeling0.45619809
119MP0005451_abnormal_body_composition0.45585873
120MP0002168_other_aberrant_phenotype0.45583099
121MP0001299_abnormal_eye_distance/0.45430445
122MP0000249_abnormal_blood_vessel0.45080207
123MP0002009_preneoplasia0.44973561
124MP0002933_joint_inflammation0.43257458
125MP0002166_altered_tumor_susceptibility0.43124484
126MP0004858_abnormal_nervous_system0.41839822
127MP0009384_cardiac_valve_regurgitation0.41567212
128MP0000762_abnormal_tongue_morphology0.41184507
129MP0005166_decreased_susceptibility_to0.39459337
130MP0005083_abnormal_biliary_tract0.39203233
131MP0010234_abnormal_vibrissa_follicle0.39189494
132MP0001765_abnormal_ion_homeostasis0.38586713
133MP0001984_abnormal_olfaction0.38130041
134MP0001614_abnormal_blood_vessel0.37900221
135MP0002254_reproductive_system_inflammat0.36693943
136MP0005376_homeostasis/metabolism_phenot0.35871578
137MP0003959_abnormal_lean_body0.35155349

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.51573662
2Exercise-induced myalgia (HP:0003738)6.10147876
3Calf muscle hypertrophy (HP:0008981)5.68872960
4Atrial fibrillation (HP:0005110)5.56972388
5Muscle hypertrophy of the lower extremities (HP:0008968)5.33842808
6Ventricular tachycardia (HP:0004756)5.24341480
7Primary atrial arrhythmia (HP:0001692)5.15234713
8Exercise-induced muscle cramps (HP:0003710)4.95320427
9Distal arthrogryposis (HP:0005684)4.87397195
10Supraventricular tachycardia (HP:0004755)4.86481775
11Muscle fiber splitting (HP:0003555)4.76415205
12Myopathic facies (HP:0002058)4.75892679
13Supraventricular arrhythmia (HP:0005115)4.74737437
14Syncope (HP:0001279)4.67729959
15Abnormality of the calf musculature (HP:0001430)4.60645941
16Centrally nucleated skeletal muscle fibers (HP:0003687)4.55180902
17Round ear (HP:0100830)4.47382421
18Hyporeflexia of lower limbs (HP:0002600)4.41846374
19Myoglobinuria (HP:0002913)4.38315514
20Right ventricular cardiomyopathy (HP:0011663)4.17929880
21Abnormality of the left ventricular outflow tract (HP:0011103)4.16275767
22Subaortic stenosis (HP:0001682)4.16275767
23Ulnar deviation of the wrist (HP:0003049)4.16099352
24Prolonged QT interval (HP:0001657)4.06088464
25Lipoatrophy (HP:0100578)3.98185659
26Bundle branch block (HP:0011710)3.75068742
27Increased connective tissue (HP:0009025)3.66204021
28EMG: myopathic abnormalities (HP:0003458)3.65941230
29Difficulty running (HP:0009046)3.65089096
30Central scotoma (HP:0000603)3.60765038
31Asymmetric septal hypertrophy (HP:0001670)3.56859854
32Type 1 muscle fiber predominance (HP:0003803)3.49460663
33Dilated cardiomyopathy (HP:0001644)3.48098793
34Heart block (HP:0012722)3.42271129
35Congenital stationary night blindness (HP:0007642)3.39937049
36Muscle fiber inclusion bodies (HP:0100299)3.37926163
37Atrioventricular block (HP:0001678)3.32364268
38Ventricular arrhythmia (HP:0004308)3.29826734
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.21378582
40Abnormal atrioventricular conduction (HP:0005150)3.16852324
41Calcaneovalgus deformity (HP:0001848)3.16152525
42Abnormal EKG (HP:0003115)3.02595444
43EMG: neuropathic changes (HP:0003445)3.01461840
44Pigmentary retinal degeneration (HP:0001146)3.00055626
45Absent phalangeal crease (HP:0006109)2.99634017
46Palpitations (HP:0001962)2.95266493
47Rhabdomyolysis (HP:0003201)2.87909791
48Spinal rigidity (HP:0003306)2.82256605
49Deformed tarsal bones (HP:0008119)2.78162177
50Hypoplastic ischia (HP:0003175)2.68047285
51Malignant hyperthermia (HP:0002047)2.65793532
52Ventricular fibrillation (HP:0001663)2.63446252
53Slender build (HP:0001533)2.62828761
54Nemaline bodies (HP:0003798)2.62527693
55Myotonia (HP:0002486)2.62089262
56Bulbar palsy (HP:0001283)2.55561201
57Left ventricular hypertrophy (HP:0001712)2.54377534
58Ketoacidosis (HP:0001993)2.49834902
59Increased variability in muscle fiber diameter (HP:0003557)2.45451241
60Abnormal finger flexion creases (HP:0006143)2.45439139
61Scotoma (HP:0000575)2.44612266
62Abolished electroretinogram (ERG) (HP:0000550)2.41897314
63Alopecia of scalp (HP:0002293)2.39261816
64Hyperkalemia (HP:0002153)2.39240159
65Abnormality of the ischium (HP:0003174)2.35715214
66Distal lower limb muscle weakness (HP:0009053)2.31278837
67Muscle stiffness (HP:0003552)2.29438602
68Dyschromatopsia (HP:0007641)2.29014865
69Difficulty climbing stairs (HP:0003551)2.28219058
70Limb-girdle muscle atrophy (HP:0003797)2.27281371
71Abnormality of skeletal muscle fiber size (HP:0012084)2.25858522
72Frequent falls (HP:0002359)2.24915507
73Unilateral renal agenesis (HP:0000122)2.24049632
74Chorioretinal atrophy (HP:0000533)2.23970359
75Hypoglycemic coma (HP:0001325)2.20541436
76Ketosis (HP:0001946)2.19908236
77Aortic aneurysm (HP:0004942)2.19010032
78Decreased central vision (HP:0007663)2.17745025
79Insulin-resistant diabetes mellitus (HP:0000831)2.15681785
80Distal lower limb amyotrophy (HP:0008944)2.13737913
81Abnormality of the foot musculature (HP:0001436)2.13128866
82Weak cry (HP:0001612)2.08223177
83Follicular hyperkeratosis (HP:0007502)2.07560835
84Dysmetric saccades (HP:0000641)2.07357140
85Hypoalphalipoproteinemia (HP:0003233)2.05340951
86Foot dorsiflexor weakness (HP:0009027)2.04797655
87Protrusio acetabuli (HP:0003179)2.03828461
88Progressive muscle weakness (HP:0003323)2.02956905
89Fatigable weakness (HP:0003473)2.02805755
90Abnormality of the neuromuscular junction (HP:0003398)2.02805755
91Hyperglycemia (HP:0003074)1.99789501
92Generalized muscle weakness (HP:0003324)1.99474798
93Muscular dystrophy (HP:0003560)1.99437647
94Scapular winging (HP:0003691)1.98450497
95Broad metatarsal (HP:0001783)1.97960750
96Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97410787
97Palmoplantar keratoderma (HP:0000982)1.95854441
98Abnormality of the calcaneus (HP:0008364)1.95289631
99Bony spicule pigmentary retinopathy (HP:0007737)1.94436880
100Facial diplegia (HP:0001349)1.91382889
101Abnormal rod and cone electroretinograms (HP:0008323)1.88527389
102Abnormality of macular pigmentation (HP:0008002)1.88261494
103Hyperinsulinemic hypoglycemia (HP:0000825)1.88047607
104Abnormality of the shoulder girdle musculature (HP:0001435)1.81980356
105Sudden cardiac death (HP:0001645)1.79837198
106Waddling gait (HP:0002515)1.79748216
107Fetal akinesia sequence (HP:0001989)1.79352804
108Bradycardia (HP:0001662)1.78318383
109Popliteal pterygium (HP:0009756)1.77637808
110Ragged-red muscle fibers (HP:0003200)1.77555564
111Neck muscle weakness (HP:0000467)1.77054873
112Large for gestational age (HP:0001520)1.76122844
113Limited hip movement (HP:0008800)1.75965528
114Pendular nystagmus (HP:0012043)1.75646730
115Abnormality of fatty-acid metabolism (HP:0004359)1.75389543
116Areflexia of lower limbs (HP:0002522)1.74095738
117Proximal amyotrophy (HP:0007126)1.73240225
118Mildly elevated creatine phosphokinase (HP:0008180)1.71604879
119Absent eyebrow (HP:0002223)1.71373916
120Limb-girdle muscle weakness (HP:0003325)1.70431233
121Renal cortical cysts (HP:0000803)1.69788383
122Dicarboxylic aciduria (HP:0003215)1.68092874
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68092874
124Lymphangioma (HP:0100764)1.68070672
125Lower limb amyotrophy (HP:0007210)1.67820540
126Gowers sign (HP:0003391)1.67741614
127Congenital sensorineural hearing impairment (HP:0008527)1.67535912
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66380710
129Hip contracture (HP:0003273)1.66337214
130Rimmed vacuoles (HP:0003805)1.64390495
131Respiratory insufficiency due to muscle weakness (HP:0002747)1.59214679
132Metatarsus adductus (HP:0001840)1.56370976
133Generalized amyotrophy (HP:0003700)1.50681697
134Steppage gait (HP:0003376)1.47150870
135Cerebral aneurysm (HP:0004944)1.45661163
136Nonprogressive disorder (HP:0003680)1.41531900
137Achilles tendon contracture (HP:0001771)1.40333455
138Vascular tortuosity (HP:0004948)1.38547010
139Aneurysm (HP:0002617)1.38154823
140Stridor (HP:0010307)1.38133902
141Easy fatigability (HP:0003388)1.33830289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.25968409
2TTN3.77830388
3SIK13.09823217
4PHKG22.90570095
5PHKG12.90570095
6INSRR2.74891113
7DMPK2.55856520
8SIK32.42476965
9LATS12.39221814
10SIK22.15886686
11PINK12.15222996
12LMTK22.10887127
13EEF2K2.01544915
14PDK31.94385847
15PDK41.94385847
16CAMK1D1.86490096
17PIK3CA1.77435211
18CAMK1G1.75525083
19STK381.65926461
20STK38L1.61941640
21MAP3K71.61510863
22MAPKAPK31.60439765
23MYLK1.59185691
24MUSK1.53813918
25PRKAA21.43270481
26TIE11.38261669
27GRK71.34806348
28TGFBR21.31915513
29ZAK1.31154037
30PRKAA11.17912383
31CDK121.14354698
32PDK21.13718046
33WNK11.11179562
34SGK21.10523707
35MARK31.09630793
36BCKDK1.08328463
37MAP3K41.04214994
38CAMK41.04199628
39SGK31.03469737
40MAP3K131.01043281
41TRIB30.98011617
42CAMK10.97997748
43MAPK120.95360422
44JAK10.93839942
45NTRK30.93819232
46RIPK10.90570428
47MAP2K40.90199532
48EPHA40.89746504
49PIK3CG0.87955144
50PRKD10.87588102
51MARK20.87397182
52ERN10.86297985
53CAMK2D0.85618633
54PKN20.82903689
55MAP3K60.80932782
56MAP3K30.76806855
57STK240.76392779
58CDC42BPA0.75579993
59LIMK10.73240416
60MOS0.70727800
61ZAP700.70310465
62MTOR0.70278307
63SGK10.69336914
64MAP3K50.67122308
65TAOK30.65836587
66PKN10.65602849
67TBK10.64625386
68TRPM70.63858687
69PRKD30.63242929
70AKT30.60962415
71CAMK2G0.60749796
72EPHA30.60692290
73BRD40.60521296
74GRK10.59680299
75MAP2K10.59292058
76NEK10.58279260
77PAK30.57676173
78ICK0.56088612
79FER0.55072936
80PRKCH0.54919686
81MAPK110.54824987
82PRKD20.54168215
83KSR20.54025974
84SGK4940.53907483
85SGK2230.53907483
86NLK0.53569658
87MAPK70.52397915
88CDK30.51647052
89MAPK40.51621155
90MAP2K70.51491950
91ROCK10.50574437
92MST1R0.50573702
93MAP2K60.50005708
94NUAK10.48800117
95CAMK2A0.48288728
96STK30.47968050
97DDR20.47937144
98NEK90.47653733
99LATS20.47519724
100TNIK0.47066199
101PRKG10.46851292
102FGFR40.46319188
103FGFR30.45494135
104PTK20.45026587
105TYK20.44171441
106PRKCE0.43806778
107MAP3K10.43753664
108DYRK1B0.41848153
109ERBB30.40980960
110MAP2K30.40666101
111PRPF4B0.40597604
112RPS6KA20.40487284
113PDGFRA0.40389746
114SMG10.40267754
115CDK80.39175190
116PDPK10.38944030
117PTK2B0.38551389
118RPS6KL10.38077862
119RPS6KC10.38077862
120PDGFRB0.37308624
121PAK20.36830105
122PRKACG0.36276836
123PRKACA0.35275446
124RPS6KA30.35227126
125AKT20.34947657
126PDK10.34352282
127WNK40.34334922
128PRKACB0.34040925
129EPHB10.31478602
130MAP3K100.30238288
131MET0.28381752
132RPS6KB20.26812460
133ROCK20.26792601
134MELK0.26586509
135RPS6KA60.25561104
136HIPK20.25077994
137NME10.24110211
138JAK30.23310237
139MAP3K140.22607348
140RPS6KB10.21952752

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.02658779
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.98443012
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.62436256
4Propanoate metabolism_Homo sapiens_hsa006402.43024113
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36491665
6Fatty acid degradation_Homo sapiens_hsa000712.32167090
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.31487934
8Cardiac muscle contraction_Homo sapiens_hsa042602.28049219
9Phototransduction_Homo sapiens_hsa047442.14635797
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06767401
11Lysine degradation_Homo sapiens_hsa003101.75848300
12Fatty acid metabolism_Homo sapiens_hsa012121.73979394
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69278524
14Type II diabetes mellitus_Homo sapiens_hsa049301.61714294
15Arginine biosynthesis_Homo sapiens_hsa002201.55014013
16PPAR signaling pathway_Homo sapiens_hsa033201.50159649
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43966630
18Circadian rhythm_Homo sapiens_hsa047101.43331505
19Pentose phosphate pathway_Homo sapiens_hsa000301.42587171
20Insulin resistance_Homo sapiens_hsa049311.39406860
21Calcium signaling pathway_Homo sapiens_hsa040201.37733092
22Phenylalanine metabolism_Homo sapiens_hsa003601.36225368
23Fructose and mannose metabolism_Homo sapiens_hsa000511.29051925
24Glucagon signaling pathway_Homo sapiens_hsa049221.24969204
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24601146
26Starch and sucrose metabolism_Homo sapiens_hsa005001.23213312
27Nitrogen metabolism_Homo sapiens_hsa009101.16982081
28Renin secretion_Homo sapiens_hsa049241.11869306
29ABC transporters_Homo sapiens_hsa020101.10698085
30Insulin secretion_Homo sapiens_hsa049111.08396512
31Circadian entrainment_Homo sapiens_hsa047131.08290183
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.06892127
33Fatty acid biosynthesis_Homo sapiens_hsa000611.04957580
34Oxytocin signaling pathway_Homo sapiens_hsa049211.04875468
35Amoebiasis_Homo sapiens_hsa051461.04716704
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03568491
37Tight junction_Homo sapiens_hsa045301.03097111
38Carbon metabolism_Homo sapiens_hsa012001.00811668
39cAMP signaling pathway_Homo sapiens_hsa040240.99009581
40Tryptophan metabolism_Homo sapiens_hsa003800.98100409
41Morphine addiction_Homo sapiens_hsa050320.93600873
42Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92289116
43Butanoate metabolism_Homo sapiens_hsa006500.91815030
44Insulin signaling pathway_Homo sapiens_hsa049100.90836885
45Pyruvate metabolism_Homo sapiens_hsa006200.90605395
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90220237
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88736250
48beta-Alanine metabolism_Homo sapiens_hsa004100.88541115
49Viral myocarditis_Homo sapiens_hsa054160.86142836
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.85997071
51Nicotine addiction_Homo sapiens_hsa050330.83357559
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.82428583
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81228587
54Platelet activation_Homo sapiens_hsa046110.81206434
55AMPK signaling pathway_Homo sapiens_hsa041520.80898446
56GABAergic synapse_Homo sapiens_hsa047270.79877742
57Proteoglycans in cancer_Homo sapiens_hsa052050.77523964
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77418420
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76225509
60Taste transduction_Homo sapiens_hsa047420.75237218
61Olfactory transduction_Homo sapiens_hsa047400.74234022
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73333130
63Other glycan degradation_Homo sapiens_hsa005110.72432468
64Bile secretion_Homo sapiens_hsa049760.71991230
65Gastric acid secretion_Homo sapiens_hsa049710.71467948
66Glutamatergic synapse_Homo sapiens_hsa047240.71441079
67Cholinergic synapse_Homo sapiens_hsa047250.71233564
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70988561
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70908536
70Ovarian steroidogenesis_Homo sapiens_hsa049130.70105249
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68513584
72Acute myeloid leukemia_Homo sapiens_hsa052210.64509525
73Biosynthesis of amino acids_Homo sapiens_hsa012300.64489115
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64407812
75Galactose metabolism_Homo sapiens_hsa000520.64162282
76VEGF signaling pathway_Homo sapiens_hsa043700.63956264
77Glycerolipid metabolism_Homo sapiens_hsa005610.63691319
78Peroxisome_Homo sapiens_hsa041460.62494434
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61936262
80Salivary secretion_Homo sapiens_hsa049700.60453531
81Tyrosine metabolism_Homo sapiens_hsa003500.60066625
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.58811146
83Histidine metabolism_Homo sapiens_hsa003400.58638868
84Focal adhesion_Homo sapiens_hsa045100.57842144
85Complement and coagulation cascades_Homo sapiens_hsa046100.57482726
86Endometrial cancer_Homo sapiens_hsa052130.57107916
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56247762
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55871369
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53348306
90HIF-1 signaling pathway_Homo sapiens_hsa040660.52941691
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.52573221
92Small cell lung cancer_Homo sapiens_hsa052220.52050596
93mTOR signaling pathway_Homo sapiens_hsa041500.51904834
94Non-small cell lung cancer_Homo sapiens_hsa052230.51379260
95Caffeine metabolism_Homo sapiens_hsa002320.51274803
96Adherens junction_Homo sapiens_hsa045200.51152797
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50939135
98Staphylococcus aureus infection_Homo sapiens_hsa051500.50500317
99Dorso-ventral axis formation_Homo sapiens_hsa043200.50410659
100Thyroid cancer_Homo sapiens_hsa052160.49760495
101Chronic myeloid leukemia_Homo sapiens_hsa052200.49333225
102Glioma_Homo sapiens_hsa052140.48908742
103ECM-receptor interaction_Homo sapiens_hsa045120.48898988
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48656037
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48472806
106Fatty acid elongation_Homo sapiens_hsa000620.48299471
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.47512775
108Pancreatic secretion_Homo sapiens_hsa049720.47402089
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47338800
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47207447
111Pancreatic cancer_Homo sapiens_hsa052120.44969293
112Mineral absorption_Homo sapiens_hsa049780.44160922
113Prostate cancer_Homo sapiens_hsa052150.42377470
114Inositol phosphate metabolism_Homo sapiens_hsa005620.40172709
115GnRH signaling pathway_Homo sapiens_hsa049120.38978394
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36533212
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.35971095
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35833307
119Protein digestion and absorption_Homo sapiens_hsa049740.35048094
120FoxO signaling pathway_Homo sapiens_hsa040680.34569056
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33957329
122Renal cell carcinoma_Homo sapiens_hsa052110.32803709
123Fat digestion and absorption_Homo sapiens_hsa049750.32363989
124Bladder cancer_Homo sapiens_hsa052190.32284021
125MAPK signaling pathway_Homo sapiens_hsa040100.31902219
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.31650051
127Osteoclast differentiation_Homo sapiens_hsa043800.31631048
128Arginine and proline metabolism_Homo sapiens_hsa003300.31354150
129Prolactin signaling pathway_Homo sapiens_hsa049170.31142998
130Choline metabolism in cancer_Homo sapiens_hsa052310.31104923
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30252104
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.29226570
133Melanogenesis_Homo sapiens_hsa049160.28854439
134Serotonergic synapse_Homo sapiens_hsa047260.28781638
135Long-term potentiation_Homo sapiens_hsa047200.28627032

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