FYN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.45660481
2neuron cell-cell adhesion (GO:0007158)5.86597512
3amino acid import (GO:0043090)5.40466591
4* activated T cell proliferation (GO:0050798)4.74790287
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71156859
6negative regulation of cell killing (GO:0031342)4.59972759
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.59972759
8L-amino acid import (GO:0043092)4.52668950
9regulation of gamma-delta T cell differentiation (GO:0045586)4.22080783
10regulation of B cell receptor signaling pathway (GO:0050855)4.21742758
11exploration behavior (GO:0035640)4.20956399
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02228263
13regulation of gamma-delta T cell activation (GO:0046643)3.94642540
14regulation of isotype switching to IgG isotypes (GO:0048302)3.88799324
15tolerance induction (GO:0002507)3.86576839
16negative T cell selection (GO:0043383)3.81672126
17leukocyte aggregation (GO:0070486)3.78239240
18negative thymic T cell selection (GO:0045060)3.71329528
19negative regulation of T cell mediated immunity (GO:0002710)3.68377768
20dermatan sulfate biosynthetic process (GO:0030208)3.66647020
21interferon-gamma production (GO:0032609)3.64767034
22negative regulation of lymphocyte mediated immunity (GO:0002707)3.62201775
23antigen processing and presentation of endogenous antigen (GO:0019883)3.58979768
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58073698
25neuron recognition (GO:0008038)3.52617623
26positive regulation of tolerance induction (GO:0002645)3.52087753
27negative regulation of axon extension (GO:0030517)3.50933308
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.42419392
29presynaptic membrane assembly (GO:0097105)3.41238306
30myelination (GO:0042552)3.39956574
31myelination in peripheral nervous system (GO:0022011)3.36694354
32peripheral nervous system axon ensheathment (GO:0032292)3.36694354
33ensheathment of neurons (GO:0007272)3.31683196
34axon ensheathment (GO:0008366)3.31683196
35negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.31501549
36cellular response to epinephrine stimulus (GO:0071872)3.30047763
37regulation of tolerance induction (GO:0002643)3.29552270
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.29487768
39dermatan sulfate metabolic process (GO:0030205)3.26760116
40positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24892122
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.23393731
42positive T cell selection (GO:0043368)3.21265117
43negative regulation of leukocyte mediated immunity (GO:0002704)3.17530154
44transmission of nerve impulse (GO:0019226)3.14436415
45dendritic spine morphogenesis (GO:0060997)3.14001213
46axonal fasciculation (GO:0007413)3.11118732
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.09503739
48presynaptic membrane organization (GO:0097090)3.08423561
49positive thymic T cell selection (GO:0045059)3.05018751
50positive regulation of granulocyte differentiation (GO:0030854)3.03750957
51regulation of alpha-beta T cell proliferation (GO:0046640)3.02903175
52Rap protein signal transduction (GO:0032486)3.01014494
53vocalization behavior (GO:0071625)3.00660806
54postsynaptic membrane organization (GO:0001941)3.00486272
55layer formation in cerebral cortex (GO:0021819)2.99996626
56negative regulation of axonogenesis (GO:0050771)2.99878349
57respiratory tube development (GO:0030323)2.98485443
58regulation of leukocyte mediated cytotoxicity (GO:0001910)2.93475672
59thymic T cell selection (GO:0045061)2.93087063
60regulation of synaptic vesicle exocytosis (GO:2000300)2.92576045
61* dendrite morphogenesis (GO:0048813)2.89517096
62neuronal ion channel clustering (GO:0045161)2.89247319
63T cell homeostasis (GO:0043029)2.89229716
64positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.89207758
65synaptic vesicle maturation (GO:0016188)2.88944527
66cellular response to interleukin-15 (GO:0071350)2.88525750
67heterotypic cell-cell adhesion (GO:0034113)2.87913446
68semaphorin-plexin signaling pathway (GO:0071526)2.86374158
69response to epinephrine (GO:0071871)2.85654045
70pyrimidine nucleobase catabolic process (GO:0006208)2.82914262
71T cell selection (GO:0045058)2.82677141
72* antigen receptor-mediated signaling pathway (GO:0050851)2.81621874
73regulation of short-term neuronal synaptic plasticity (GO:0048172)2.81289502
74regulation of cell killing (GO:0031341)2.80752475
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80425178
76axon ensheathment in central nervous system (GO:0032291)2.79850163
77central nervous system myelination (GO:0022010)2.79850163
78long-term synaptic potentiation (GO:0060291)2.78137419
79positive regulation of neurological system process (GO:0031646)2.76122410
80response to interleukin-15 (GO:0070672)2.76007543
81regulation of axon regeneration (GO:0048679)2.75761932
82regulation of neuron projection regeneration (GO:0070570)2.75761932
83regulation of B cell differentiation (GO:0045577)2.75403509
84positive regulation of cell killing (GO:0031343)2.75132492
85C4-dicarboxylate transport (GO:0015740)2.74277480
86regulation of glutamate receptor signaling pathway (GO:1900449)2.72449743
87negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.72234832
88negative regulation of neurotransmitter secretion (GO:0046929)2.71916408
89nerve growth factor signaling pathway (GO:0038180)2.71249907
90regulation of transmission of nerve impulse (GO:0051969)2.69376439
91protein localization to synapse (GO:0035418)2.68504570
92positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66956320
93response to methylmercury (GO:0051597)2.65861215
94glutamate receptor signaling pathway (GO:0007215)2.64830812
95establishment of nucleus localization (GO:0040023)2.64466065
96cortical actin cytoskeleton organization (GO:0030866)2.62601329
97substantia nigra development (GO:0021762)2.60589126
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59132478
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.58567282
100regulation of T cell mediated cytotoxicity (GO:0001914)2.57488149
101regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.56745426
102regulation of natural killer cell mediated immunity (GO:0002715)2.56745426
103positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.54943269
104positive regulation of natural killer cell mediated immunity (GO:0002717)2.54943269
105signal complex assembly (GO:0007172)2.54672598
106positive regulation of gamma-delta T cell activation (GO:0046645)2.54540548
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54210992
108* T cell receptor signaling pathway (GO:0050852)2.53901066
109synaptic vesicle exocytosis (GO:0016079)2.53007799
110positive regulation of B cell differentiation (GO:0045579)2.52050180
111negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.51939892
112negative regulation of adaptive immune response (GO:0002820)2.51502818
113regulation of T cell tolerance induction (GO:0002664)2.51031397
114negative regulation of B cell mediated immunity (GO:0002713)2.50770364
115negative regulation of immunoglobulin mediated immune response (GO:0002890)2.50770364
116regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.50466759
117negative regulation of neurotransmitter transport (GO:0051589)2.49387706
118regulation of extent of cell growth (GO:0061387)2.49226897
119regulation of collateral sprouting (GO:0048670)2.48721581
120T cell differentiation (GO:0030217)2.47638313
121alpha-beta T cell differentiation (GO:0046632)2.47320808
122positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.46415205
123cortical cytoskeleton organization (GO:0030865)2.45284909
124antigen processing and presentation via MHC class Ib (GO:0002475)2.43924291
125natural killer cell differentiation (GO:0001779)2.43876496
126B cell receptor signaling pathway (GO:0050853)2.43830815
127positive regulation of Rap GTPase activity (GO:0032854)2.42838626
128positive regulation of synapse assembly (GO:0051965)2.41854720
129regulation of regulatory T cell differentiation (GO:0045589)2.41618720
130cellular response to catecholamine stimulus (GO:0071870)2.41017796
131cellular response to monoamine stimulus (GO:0071868)2.41017796
132mast cell activation (GO:0045576)2.39786412
133* T cell costimulation (GO:0031295)2.39774341
134regulation of synaptic vesicle transport (GO:1902803)2.39254192
135negative regulation of neural precursor cell proliferation (GO:2000178)2.39215981
136cerebellar granule cell differentiation (GO:0021707)2.39195306
137positive regulation of interleukin-2 production (GO:0032743)2.38956802
138morphogenesis of an endothelium (GO:0003159)2.38857797
139endothelial tube morphogenesis (GO:0061154)2.38857797
140astrocyte differentiation (GO:0048708)2.38403152
141glutamate secretion (GO:0014047)2.38069895
142positive regulation of humoral immune response (GO:0002922)2.36943292
143regulation of axon extension (GO:0030516)2.36805580
144* lymphocyte costimulation (GO:0031294)2.36259778
145cerebellar Purkinje cell differentiation (GO:0021702)2.36067690
146T cell migration (GO:0072678)2.36038240
147positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.35302467
148regulation of interleukin-2 biosynthetic process (GO:0045076)2.35133536
149regulation of granulocyte differentiation (GO:0030852)2.34406586
150positive regulation of calcium-mediated signaling (GO:0050850)2.32939609
151regulation of Rap GTPase activity (GO:0032317)2.29624328
152negative regulation of erythrocyte differentiation (GO:0045647)2.29614846
153negative regulation of cAMP-mediated signaling (GO:0043951)2.27910731
154negative regulation of interleukin-12 production (GO:0032695)2.26651895
155positive regulation of T cell mediated cytotoxicity (GO:0001916)2.26111514
156pyrimidine ribonucleoside catabolic process (GO:0046133)2.23312432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.83043315
2EZH2_22144423_ChIP-Seq_EOC_Human3.45744915
3AR_21572438_ChIP-Seq_LNCaP_Human3.02527612
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71994915
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63934274
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.61355259
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49212078
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46487825
9RUNX_20019798_ChIP-Seq_JUKART_Human2.37156684
10DROSHA_22980978_ChIP-Seq_HELA_Human2.29392823
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24469650
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24469650
13GBX2_23144817_ChIP-Seq_PC3_Human2.21728014
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14963725
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09978300
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08236465
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.05367607
18RNF2_27304074_Chip-Seq_ESCs_Mouse1.99792246
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98860105
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.97369388
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.97179571
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96012514
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95206491
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90230704
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89814499
26* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89067228
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.87221224
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85589222
29* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85046372
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76760677
31MYB_26560356_Chip-Seq_TH2_Human1.72944337
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.72838112
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.70270402
34* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68057339
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67630905
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62042081
37UTX_26944678_Chip-Seq_JUKART_Human1.61709232
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59008680
39REST_21632747_ChIP-Seq_MESCs_Mouse1.58472264
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58397790
41MAF_26560356_Chip-Seq_TH1_Human1.57589741
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.56007475
43* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54948324
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52720545
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49726536
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48583673
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48071005
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48061198
49* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44485953
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43690669
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41720021
52KDM2B_26808549_Chip-Seq_DND41_Human1.39644748
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39126792
54MAF_26560356_Chip-Seq_TH2_Human1.38990694
55GATA3_27048872_Chip-Seq_THYMUS_Human1.38582052
56* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36552056
57TP53_16413492_ChIP-PET_HCT116_Human1.35986953
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34804055
59TCF7_22412390_ChIP-Seq_EML_Mouse1.33416892
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31999170
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31577296
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31315149
63TAF15_26573619_Chip-Seq_HEK293_Human1.31099864
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.30771431
65* PRDM14_20953172_ChIP-Seq_ESCs_Human1.30386383
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29104056
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28159731
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27629545
69MYB_26560356_Chip-Seq_TH1_Human1.26955571
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26659315
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26594678
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26594678
73SMAD4_21799915_ChIP-Seq_A2780_Human1.26265776
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25536867
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25466709
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.24810276
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23387362
78* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21701315
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.21150766
80MYC_22102868_ChIP-Seq_BL_Human1.20424881
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20346241
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.18811965
83* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17978899
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.17810546
85* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17264160
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.16217150
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14933348
88* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14765624
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13870074
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12816452
91* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12707787
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12606499
93SCL_19346495_ChIP-Seq_HPC-7_Human1.12531459
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.11902753
95P300_19829295_ChIP-Seq_ESCs_Human1.11261737
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10960943
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10472837
98* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10163784
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09506744
100VDR_24787735_ChIP-Seq_THP-1_Human1.08633192
101* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07991442
102* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06043766
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05880388
104AR_19668381_ChIP-Seq_PC3_Human1.04368164
105AHR_22903824_ChIP-Seq_MCF-7_Human1.04232049
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03854336
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02350741
108KDM2B_26808549_Chip-Seq_K562_Human1.02338006
109CBX2_27304074_Chip-Seq_ESCs_Mouse1.02269437
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01615542
111SPI1_23127762_ChIP-Seq_K562_Human0.99345837
112* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98015155
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.97847271
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97581503
115ZNF274_21170338_ChIP-Seq_K562_Hela0.97246755
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.96995309
117ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96795251
118ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96498787
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.96375299
120ER_23166858_ChIP-Seq_MCF-7_Human0.96247592
121* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95977664
122BP1_19119308_ChIP-ChIP_Hs578T_Human0.94018404
123RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93679585
124* STAT3_23295773_ChIP-Seq_U87_Human0.93367483
125* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93362341
126* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93174334
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93111538
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92515310
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92427474
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.92280377
131* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89823747
132MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89749660
133RUNX1_22412390_ChIP-Seq_EML_Mouse0.88600962
134PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87453715
135VDR_21846776_ChIP-Seq_THP-1_Human0.85102041
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84920753
137* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84585155
138NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83758019
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82808258
140SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81530157
141* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.80639920
142PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80349099
143VDR_24763502_ChIP-Seq_THP-1_Human0.76960237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.44001741
2MP0003880_abnormal_central_pattern3.74155771
3MP0000920_abnormal_myelination2.95695959
4* MP0003635_abnormal_synaptic_transmissio2.85951294
5MP0005423_abnormal_somatic_nervous2.63167798
6MP0004742_abnormal_vestibular_system2.60133655
7MP0005623_abnormal_meninges_morphology2.53884425
8* MP0000778_abnormal_nervous_system2.35621834
9MP0001835_abnormal_antigen_presentation2.35280698
10MP0003724_increased_susceptibility_to2.29275289
11MP0004134_abnormal_chest_morphology2.21060301
12* MP0002063_abnormal_learning/memory/cond2.20722190
13MP0003436_decreased_susceptibility_to2.19767266
14* MP0002064_seizures2.18532918
15* MP0009745_abnormal_behavioral_response2.17811671
16MP0003172_abnormal_lysosome_physiology2.17075277
17MP0004270_analgesia2.13559815
18MP0005387_immune_system_phenotype1.99962581
19MP0001790_abnormal_immune_system1.99962581
20MP0001486_abnormal_startle_reflex1.96194185
21MP0001440_abnormal_grooming_behavior1.94229114
22* MP0003763_abnormal_thymus_physiology1.93977789
23MP0004510_myositis1.86943769
24* MP0002572_abnormal_emotion/affect_behav1.85068005
25MP0002184_abnormal_innervation1.84996378
26MP0002272_abnormal_nervous_system1.81712914
27MP0004145_abnormal_muscle_electrophysio1.80376408
28MP0008569_lethality_at_weaning1.79213682
29MP0003329_amyloid_beta_deposits1.76167996
30MP0002405_respiratory_system_inflammati1.71980046
31MP0004381_abnormal_hair_follicle1.70298268
32MP0005025_abnormal_response_to1.68533236
33MP0003690_abnormal_glial_cell1.67956184
34MP0001968_abnormal_touch/_nociception1.62717330
35* MP0002452_abnormal_antigen_presenting1.61224945
36MP0000955_abnormal_spinal_cord1.59890800
37MP0004885_abnormal_endolymph1.59386395
38* MP0000716_abnormal_immune_system1.58484088
39MP0002734_abnormal_mechanical_nocicepti1.57940948
40MP0005171_absent_coat_pigmentation1.55280413
41MP0003634_abnormal_glial_cell1.55191499
42MP0002638_abnormal_pupillary_reflex1.51998672
43MP0003303_peritoneal_inflammation1.51283370
44MP0002067_abnormal_sensory_capabilities1.48541052
45MP0005257_abnormal_intraocular_pressure1.47598932
46MP0003787_abnormal_imprinting1.44390369
47MP0004185_abnormal_adipocyte_glucose1.41581242
48MP0009046_muscle_twitch1.41015085
49* MP0002419_abnormal_innate_immunity1.36585635
50MP0004858_abnormal_nervous_system1.32922986
51MP0000569_abnormal_digit_pigmentation1.31460221
52MP0005671_abnormal_response_to1.31312285
53MP0009785_altered_susceptibility_to1.30432089
54* MP0002882_abnormal_neuron_morphology1.29375241
55MP0001529_abnormal_vocalization1.28066017
56MP0004811_abnormal_neuron_physiology1.26196674
57MP0009780_abnormal_chondrocyte_physiolo1.24719013
58* MP0002722_abnormal_immune_system1.23520579
59MP0001958_emphysema1.21873658
60* MP0000689_abnormal_spleen_morphology1.20915878
61MP0001970_abnormal_pain_threshold1.20357314
62* MP0002557_abnormal_social/conspecific_i1.20190311
63MP0003091_abnormal_cell_migration1.16946444
64MP0002733_abnormal_thermal_nociception1.16207124
65MP0004924_abnormal_behavior1.13903315
66MP0005386_behavior/neurological_phenoty1.13903315
67MP0002736_abnormal_nociception_after1.13078017
68MP0003385_abnormal_body_wall1.12608025
69MP0001299_abnormal_eye_distance/1.12455833
70* MP0002066_abnormal_motor_capabilities/c1.11990938
71* MP0002152_abnormal_brain_morphology1.09440153
72MP0010155_abnormal_intestine_physiology1.09217258
73* MP0002429_abnormal_blood_cell1.08111121
74MP0009333_abnormal_splenocyte_physiolog1.07435480
75MP0003632_abnormal_nervous_system1.06982004
76MP0009384_cardiac_valve_regurgitation1.06757139
77MP0002735_abnormal_chemical_nociception1.04478101
78MP0002089_abnormal_postnatal_growth/wei1.04316403
79MP0001485_abnormal_pinna_reflex1.04049628
80MP0000604_amyloidosis1.03754343
81MP0000751_myopathy1.03504686
82MP0003866_abnormal_defecation1.03095534
83MP0002009_preneoplasia1.01454276
84MP0004142_abnormal_muscle_tone1.00935153
85MP0002653_abnormal_ependyma_morphology0.97854642
86MP0004947_skin_inflammation0.96168705
87MP0000631_abnormal_neuroendocrine_gland0.94768704
88MP0005409_darkened_coat_color0.94054406
89MP0002822_catalepsy0.92685878
90MP0003045_fibrosis0.90603325
91MP0006276_abnormal_autonomic_nervous0.90587413
92MP0003300_gastrointestinal_ulcer0.90108119
93* MP0000703_abnormal_thymus_morphology0.89810879
94MP0003631_nervous_system_phenotype0.89252305
95MP0001501_abnormal_sleep_pattern0.87743831
96MP0001533_abnormal_skeleton_physiology0.87159510
97MP0000733_abnormal_muscle_development0.86651161
98MP0003121_genomic_imprinting0.85626727
99MP0001348_abnormal_lacrimal_gland0.84856140
100MP0003633_abnormal_nervous_system0.84772228
101MP0003861_abnormal_nervous_system0.83042402
102MP0001845_abnormal_inflammatory_respons0.82534659
103MP0006082_CNS_inflammation0.81828299
104MP0003122_maternal_imprinting0.81648256
105MP0001851_eye_inflammation0.78271038
106MP0005464_abnormal_platelet_physiology0.78252923
107* MP0002420_abnormal_adaptive_immunity0.77601521
108MP0001879_abnormal_lymphatic_vessel0.77404144
109MP0001819_abnormal_immune_cell0.76743563
110MP0004130_abnormal_muscle_cell0.76691270
111* MP0002148_abnormal_hypersensitivity_rea0.75808806
112MP0001943_abnormal_respiration0.75543132
113MP0002282_abnormal_trachea_morphology0.75183003
114MP0002998_abnormal_bone_remodeling0.75152745
115* MP0002752_abnormal_somatic_nervous0.74733212
116MP0001502_abnormal_circadian_rhythm0.74443195
117MP0003868_abnormal_feces_composition0.73706137
118MP0001963_abnormal_hearing_physiology0.72676747
119MP0003136_yellow_coat_color0.72674980
120* MP0001800_abnormal_humoral_immune0.72463872
121MP0005645_abnormal_hypothalamus_physiol0.72162082
122* MP0002398_abnormal_bone_marrow0.71922791
123MP0001984_abnormal_olfaction0.71670943
124MP0005310_abnormal_salivary_gland0.71581700
125MP0001986_abnormal_taste_sensitivity0.71148548
126MP0002166_altered_tumor_susceptibility0.70993190
127MP0000685_abnormal_immune_system0.69551847
128MP0002933_joint_inflammation0.68566269
129MP0008260_abnormal_autophagy0.67260812
130* MP0005000_abnormal_immune_tolerance0.67073762
131MP0000465_gastrointestinal_hemorrhage0.66853572
132* MP0002723_abnormal_immune_serum0.63778978
133MP0001873_stomach_inflammation0.62830949

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.47446836
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.46046490
3Degeneration of the lateral corticospinal tracts (HP:0002314)3.46046490
4Abnormality of the corticospinal tract (HP:0002492)3.45023185
5Severe combined immunodeficiency (HP:0004430)3.42801854
6Peripheral hypomyelination (HP:0007182)3.34504576
7Atonic seizures (HP:0010819)3.32359055
8Myositis (HP:0100614)3.23576567
9Epiphyseal dysplasia (HP:0002656)3.15813238
10Optic neuritis (HP:0100653)3.12805818
11Retrobulbar optic neuritis (HP:0100654)3.12805818
12Abnormality of T cells (HP:0002843)3.10038456
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.03881243
14Leukocytosis (HP:0001974)3.00983034
15Supranuclear gaze palsy (HP:0000605)2.98968101
16Neurofibrillary tangles (HP:0002185)2.96587847
17Focal seizures (HP:0007359)2.91767166
18Abnormality of eosinophils (HP:0001879)2.91671262
19Gastrointestinal infarctions (HP:0005244)2.87761492
20Focal motor seizures (HP:0011153)2.85323483
21Recurrent fungal infections (HP:0002841)2.85269608
22Orchitis (HP:0100796)2.81313485
23Spontaneous hematomas (HP:0007420)2.79216955
24Deep palmar crease (HP:0006191)2.77808702
25Cerebral inclusion bodies (HP:0100314)2.72937908
26Encephalitis (HP:0002383)2.71619436
27Akinesia (HP:0002304)2.70559375
28Obstructive sleep apnea (HP:0002870)2.66154656
29Action tremor (HP:0002345)2.65036623
30Spastic gait (HP:0002064)2.64660031
31Insidious onset (HP:0003587)2.63748418
32Termporal pattern (HP:0011008)2.63748418
33Meningitis (HP:0001287)2.62794766
34T lymphocytopenia (HP:0005403)2.62687596
35Broad ribs (HP:0000885)2.61870595
36Hypoplasia of the thymus (HP:0000778)2.61743506
37Autoimmune hemolytic anemia (HP:0001890)2.61340790
38Abnormality of binocular vision (HP:0011514)2.60594267
39Diplopia (HP:0000651)2.60594267
40Absent speech (HP:0001344)2.59271025
41Sensory axonal neuropathy (HP:0003390)2.58620178
42Chronic mucocutaneous candidiasis (HP:0002728)2.54962555
43Recurrent cutaneous fungal infections (HP:0011370)2.54962555
44Increased IgM level (HP:0003496)2.54924294
45Visual hallucinations (HP:0002367)2.53060995
46Pulmonary infiltrates (HP:0002113)2.53057361
47Ankle clonus (HP:0011448)2.49189610
48Abnormality of T cell number (HP:0011839)2.48757075
49Eosinophilia (HP:0001880)2.47832817
50IgG deficiency (HP:0004315)2.45769145
51Recurrent abscess formation (HP:0002722)2.44164496
52Microglossia (HP:0000171)2.43391787
53Myokymia (HP:0002411)2.42974540
54Small epiphyses (HP:0010585)2.42904415
55Vasculitis (HP:0002633)2.40200851
56Premature skin wrinkling (HP:0100678)2.36266071
57Broad-based gait (HP:0002136)2.34579299
58Thyroiditis (HP:0100646)2.34549836
59Dysmetria (HP:0001310)2.33948243
60Combined immunodeficiency (HP:0005387)2.31859283
61Recurrent bacterial skin infections (HP:0005406)2.31115975
62Fetal akinesia sequence (HP:0001989)2.30903629
63Abnormality of the 4th metacarpal (HP:0010012)2.30456122
64Lymphopenia (HP:0001888)2.29507733
65Abnormality of the parathyroid morphology (HP:0011766)2.27659410
66Pachygyria (HP:0001302)2.26681954
67Short 4th metacarpal (HP:0010044)2.25326942
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.25326942
69Genetic anticipation (HP:0003743)2.24133428
70Hemoptysis (HP:0002105)2.21899444
71Amyotrophic lateral sclerosis (HP:0007354)2.19332464
72Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19328560
73Pulmonary embolism (HP:0002204)2.18286631
74Chronic obstructive pulmonary disease (HP:0006510)2.17672216
75Obstructive lung disease (HP:0006536)2.17672216
76Granulocytopenia (HP:0001913)2.16995152
77Megalencephaly (HP:0001355)2.16084990
78Gingivitis (HP:0000230)2.14917434
79Abnormality of cells of the lymphoid lineage (HP:0012140)2.12950189
80Progressive cerebellar ataxia (HP:0002073)2.12858480
81Urinary urgency (HP:0000012)2.12197544
82Recurrent bronchitis (HP:0002837)2.11982655
83Keratoconjunctivitis sicca (HP:0001097)2.11752094
84Chest pain (HP:0100749)2.11553484
85Mediastinal lymphadenopathy (HP:0100721)2.06640625
86Arterial tortuosity (HP:0005116)2.06626259
87Open mouth (HP:0000194)2.02988366
88Chin dimple (HP:0010751)2.02668028
89Aplasia/Hypoplasia of the brainstem (HP:0007362)1.99598813
90Hypoplasia of the brainstem (HP:0002365)1.99598813
91Adrenal hypoplasia (HP:0000835)1.99083217
92Stomatitis (HP:0010280)1.99081808
93Abnormality of macrophages (HP:0004311)1.99078730
94Pustule (HP:0200039)1.98781438
95Recurrent viral infections (HP:0004429)1.98724446
96Vitreoretinal degeneration (HP:0000655)1.97433325
97Epileptic encephalopathy (HP:0200134)1.96691238
98Recurrent gram-negative bacterial infections (HP:0005420)1.96636838
99Supernumerary bones of the axial skeleton (HP:0009144)1.96385347
100Mild short stature (HP:0003502)1.95592329
101Drooling (HP:0002307)1.95194472
102Excessive salivation (HP:0003781)1.95194472
103Macroorchidism (HP:0000053)1.94128727
104Keratoconjunctivitis (HP:0001096)1.94059573
105Recurrent skin infections (HP:0001581)1.93166579
106Lower limb asymmetry (HP:0100559)1.90692704
107Febrile seizures (HP:0002373)1.88269922
108Scanning speech (HP:0002168)1.88166444
109Intention tremor (HP:0002080)1.87754177
110Aqueductal stenosis (HP:0002410)1.86283363
111Mutism (HP:0002300)1.86051570
112Stereotypic behavior (HP:0000733)1.85892929
113Abnormality of the fingertips (HP:0001211)1.84938345
114Hypochromic anemia (HP:0001931)1.84885403
115Agammaglobulinemia (HP:0004432)1.83773797
116Relative macrocephaly (HP:0004482)1.83543883
117Dysdiadochokinesis (HP:0002075)1.82081677
118Hemiplegia (HP:0002301)1.81764818
119Vascular tortuosity (HP:0004948)1.80995710
120Supernumerary nipples (HP:0002558)1.80019420
121Scapular winging (HP:0003691)1.79137972
122Anomalous pulmonary venous return (HP:0010772)1.77447721
123Lower limb muscle weakness (HP:0007340)1.76548026
124Generalized hypotonia (HP:0001290)1.76369743
125Increased IgE level (HP:0003212)1.76321535
126Peritonitis (HP:0002586)1.76283564
127Apathy (HP:0000741)1.76136228
128Prolonged bleeding time (HP:0003010)1.75923336
129Oligodactyly (hands) (HP:0001180)1.75896192
130Heterochromia iridis (HP:0001100)1.75391342
131Urinary bladder sphincter dysfunction (HP:0002839)1.75074309
132Trigonocephaly (HP:0000243)1.74585330
133Progressive inability to walk (HP:0002505)1.72460345
134Increased density of long bones (HP:0006392)1.71037088
135Sporadic (HP:0003745)1.70449535
136Abnormality of oral frenula (HP:0000190)1.69737016
137Panhypogammaglobulinemia (HP:0003139)1.69529420
138Bowel incontinence (HP:0002607)1.69130957
139Impaired vibration sensation in the lower limbs (HP:0002166)1.68390144
140Blue irides (HP:0000635)1.66450998
141Hypoplasia of the iris (HP:0007676)1.65829859
142Plagiocephaly (HP:0001357)1.64510964
143Inflammation of the large intestine (HP:0002037)1.64427150
144Mitral regurgitation (HP:0001653)1.63718837
145Truncal ataxia (HP:0002078)1.63642755
146Hypoplastic pelvis (HP:0008839)1.62112488
147Gastrointestinal inflammation (HP:0004386)1.61735411
148Onion bulb formation (HP:0003383)1.61704938
149Elevated erythrocyte sedimentation rate (HP:0003565)1.61140348
150Papilledema (HP:0001085)1.60600667
151Lower limb amyotrophy (HP:0007210)1.59512641
152Pointed chin (HP:0000307)1.59442037
153Abnormal auditory evoked potentials (HP:0006958)1.59289284
154Abnormality of the intervertebral disk (HP:0005108)1.58981070
155Increased variability in muscle fiber diameter (HP:0003557)1.58950671
156Supernumerary ribs (HP:0005815)1.58655207
157Absent hand (HP:0004050)1.57860189
158Dislocated radial head (HP:0003083)1.57795223
159Lissencephaly (HP:0001339)1.56239983
160Centrally nucleated skeletal muscle fibers (HP:0003687)1.55982560
161Overgrowth (HP:0001548)1.55600181
162Abnormal eating behavior (HP:0100738)1.55473544
163Hypergammaglobulinemia (HP:0010702)1.55437461
164Joint swelling (HP:0001386)1.55220597
165Hyperthyroidism (HP:0000836)1.55053278
166Vertebral arch anomaly (HP:0008438)1.55009562
167Congenital hip dislocation (HP:0001374)1.53343805
168Limb dystonia (HP:0002451)1.53267269
169Tented upper lip vermilion (HP:0010804)1.53144580
170Diminished motivation (HP:0000745)1.53106904
171Gaze-evoked nystagmus (HP:0000640)1.51790957
172Slow saccadic eye movements (HP:0000514)1.51629522

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.30272739
2MARK13.47828952
3EPHB12.49529504
4TXK2.26061585
5MAPK132.24783931
6NTRK22.22845138
7ICK1.96113029
8MAP4K11.94197921
9PKN11.85543928
10SIK21.83970640
11RIPK41.77060862
12CASK1.74567608
13IRAK21.72615550
14EPHA41.68585809
15NTRK31.63597121
16PRKCH1.60604170
17STK391.57069826
18ITK1.54458071
19MAP3K41.53861890
20MINK11.52251620
21PAK61.50252706
22BTK1.50127041
23MARK21.47969936
24TYK21.46312025
25MAP3K101.45708403
26TAOK31.42835821
27IRAK11.41557343
28* TYRO31.40564480
29* CSK1.40348094
30UHMK11.39000178
31DMPK1.38868060
32KSR11.38444161
33TRIB31.37879167
34SYK1.34749290
35PRKCQ1.34423179
36PNCK1.33843183
37PRPF4B1.33785322
38CAMKK21.30883676
39MAP3K91.30365928
40KSR21.30287620
41ROCK21.28727185
42RET1.26117988
43RIPK11.25896539
44JAK31.24190434
45NTRK11.19062796
46EPHA31.18271258
47SGK21.12122572
48SIK31.07573567
49FGR1.07363232
50NLK1.04348205
51SGK2231.03644491
52SGK4941.03644491
53CDK51.01296773
54TEC1.00796961
55PAK30.97313321
56ROCK10.95917904
57* LCK0.95739228
58JAK20.92499296
59BLK0.92302726
60JAK10.92178475
61IKBKE0.91951441
62CSNK1G20.91383083
63TAOK10.91118770
64LIMK10.88967554
65HIPK20.88426128
66MAP3K130.87037725
67SGK30.86223011
68CAMK1G0.85493115
69PHKG10.84919034
70PHKG20.84919034
71ALK0.83580617
72IRAK40.81320628
73MARK30.80888740
74PLK20.80020425
75PKN20.79396716
76BRD40.78260915
77CSNK1G30.77303276
78TNK20.76827449
79* LYN0.76685604
80HCK0.76652898
81FGFR40.76309529
82MAP3K110.75664537
83GRK60.75152454
84MOS0.73102593
85FGFR30.72876216
86CSNK1A1L0.72710201
87STK110.72399768
88* FYN0.71011101
89* FES0.70709257
90PTK20.69910677
91PIM10.68425151
92MAP2K70.67352180
93KDR0.66523142
94PTK2B0.66314441
95* INSR0.64113627
96DYRK1A0.63604398
97NEK60.63532207
98CDK140.62670393
99DYRK20.61430730
100MAP3K70.61361276
101CAMKK10.60836707
102* PDGFRB0.60124897
103DYRK1B0.59924220
104MAP3K10.59664793
105MAPK70.59412114
106YES10.58294561
107MAP3K20.57719623
108FGFR20.57711073
109PDK10.56831662
110CLK10.56336098
111PRKD20.55240974
112PTK60.55170922
113CSNK1G10.55006058
114WNK10.53819106
115EPHB20.53780651
116SGK10.53696272
117PDGFRA0.53347065
118MAPK120.51939446
119STK380.51842365
120CDK150.51690593
121CAMK2A0.51466983
122MAPK100.50971478
123DAPK20.50577848
124GSK3A0.49200835
125ZAP700.48697392
126CDK180.48688693
127CAMK40.48340116
128MAP2K30.48043592
129OXSR10.47657526
130RAF10.47457166
131PASK0.47149881
132STK100.46984806
133PRKD30.46857814
134CDK11A0.46458127
135EEF2K0.45515238
136* SRC0.44255822
137KIT0.43516483
138BMPR20.43464827
139MAP2K40.43188026
140CAMK10.42184007
141CDK120.39571635
142PRKCZ0.39238930
143LRRK20.38856979
144CDK190.37061423

Predicted pathways (KEGG)

RankGene SetZ-score
1* T cell receptor signaling pathway_Homo sapiens_hsa046602.08574999
2Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.95436121
3* Axon guidance_Homo sapiens_hsa043601.80778272
4Glutamatergic synapse_Homo sapiens_hsa047241.80338741
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74270708
6Long-term potentiation_Homo sapiens_hsa047201.67659137
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67656043
8* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63903044
9Primary immunodeficiency_Homo sapiens_hsa053401.59221259
10Long-term depression_Homo sapiens_hsa047301.54276745
11Renal cell carcinoma_Homo sapiens_hsa052111.52722767
12* Cholinergic synapse_Homo sapiens_hsa047251.52141553
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44873177
14Nicotine addiction_Homo sapiens_hsa050331.43021808
15Dopaminergic synapse_Homo sapiens_hsa047281.41115372
16Morphine addiction_Homo sapiens_hsa050321.35344884
17Choline metabolism in cancer_Homo sapiens_hsa052311.31820429
18Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31369241
19Circadian entrainment_Homo sapiens_hsa047131.31273496
20Colorectal cancer_Homo sapiens_hsa052101.30625077
21B cell receptor signaling pathway_Homo sapiens_hsa046621.29574744
22Oxytocin signaling pathway_Homo sapiens_hsa049211.26293310
23* Viral myocarditis_Homo sapiens_hsa054161.25390914
24GABAergic synapse_Homo sapiens_hsa047271.24171194
25Glioma_Homo sapiens_hsa052141.23439187
26Hematopoietic cell lineage_Homo sapiens_hsa046401.20735288
27VEGF signaling pathway_Homo sapiens_hsa043701.20715655
28Pancreatic cancer_Homo sapiens_hsa052121.20325691
29Gastric acid secretion_Homo sapiens_hsa049711.19943819
30Leishmaniasis_Homo sapiens_hsa051401.17134194
31Notch signaling pathway_Homo sapiens_hsa043301.16018013
32Salivary secretion_Homo sapiens_hsa049701.15723346
33Renin secretion_Homo sapiens_hsa049241.14908615
34Endometrial cancer_Homo sapiens_hsa052131.12474935
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.12265884
36Olfactory transduction_Homo sapiens_hsa047401.11709229
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11601504
38ErbB signaling pathway_Homo sapiens_hsa040121.10198897
39Antigen processing and presentation_Homo sapiens_hsa046121.10070302
40GnRH signaling pathway_Homo sapiens_hsa049121.09512356
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09497617
42Type I diabetes mellitus_Homo sapiens_hsa049401.09320537
43Dorso-ventral axis formation_Homo sapiens_hsa043201.08931775
44Chemokine signaling pathway_Homo sapiens_hsa040621.08390055
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08361516
46Malaria_Homo sapiens_hsa051441.08091723
47Estrogen signaling pathway_Homo sapiens_hsa049151.06841026
48* Phospholipase D signaling pathway_Homo sapiens_hsa040721.06601803
49Gap junction_Homo sapiens_hsa045401.06523877
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06481583
51Serotonergic synapse_Homo sapiens_hsa047261.05944656
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04664572
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04402792
54Amphetamine addiction_Homo sapiens_hsa050311.02981046
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02871775
56* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02673087
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01171973
58* Platelet activation_Homo sapiens_hsa046111.00826800
59Graft-versus-host disease_Homo sapiens_hsa053320.99726274
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.98779843
61* Sphingolipid signaling pathway_Homo sapiens_hsa040710.98556735
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.98273971
63Synaptic vesicle cycle_Homo sapiens_hsa047210.98247138
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98168260
65Chronic myeloid leukemia_Homo sapiens_hsa052200.97192596
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96862492
67FoxO signaling pathway_Homo sapiens_hsa040680.92975785
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92854743
69Shigellosis_Homo sapiens_hsa051310.92713731
70Non-small cell lung cancer_Homo sapiens_hsa052230.92292340
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89971622
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86740885
73Allograft rejection_Homo sapiens_hsa053300.86354822
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86327483
75* Focal adhesion_Homo sapiens_hsa045100.86016873
76MAPK signaling pathway_Homo sapiens_hsa040100.84230892
77TNF signaling pathway_Homo sapiens_hsa046680.83929527
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83630233
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.83451338
80cAMP signaling pathway_Homo sapiens_hsa040240.83157494
81* Osteoclast differentiation_Homo sapiens_hsa043800.81947090
82Ras signaling pathway_Homo sapiens_hsa040140.81920673
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81599861
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.81222128
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80722035
86Rap1 signaling pathway_Homo sapiens_hsa040150.80187825
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79958276
88Cocaine addiction_Homo sapiens_hsa050300.79708991
89* Measles_Homo sapiens_hsa051620.79631141
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78235877
91Endocytosis_Homo sapiens_hsa041440.77678335
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77424662
93Acute myeloid leukemia_Homo sapiens_hsa052210.76285409
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75760268
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75198740
96Tuberculosis_Homo sapiens_hsa051520.73729608
97Prolactin signaling pathway_Homo sapiens_hsa049170.72925300
98MicroRNAs in cancer_Homo sapiens_hsa052060.71502185
99Type II diabetes mellitus_Homo sapiens_hsa049300.71469635
100Ether lipid metabolism_Homo sapiens_hsa005650.70701963
101mTOR signaling pathway_Homo sapiens_hsa041500.69030075
102Autoimmune thyroid disease_Homo sapiens_hsa053200.68359086
103Staphylococcus aureus infection_Homo sapiens_hsa051500.67696626
104Calcium signaling pathway_Homo sapiens_hsa040200.67111742
105Prostate cancer_Homo sapiens_hsa052150.66738226
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66186577
107Melanogenesis_Homo sapiens_hsa049160.65373108
108Toxoplasmosis_Homo sapiens_hsa051450.64568487
109Dilated cardiomyopathy_Homo sapiens_hsa054140.63973006
110Apoptosis_Homo sapiens_hsa042100.63838434
111Inositol phosphate metabolism_Homo sapiens_hsa005620.63606044
112HTLV-I infection_Homo sapiens_hsa051660.63572415
113Pancreatic secretion_Homo sapiens_hsa049720.61786758
114ECM-receptor interaction_Homo sapiens_hsa045120.61305415
115Steroid biosynthesis_Homo sapiens_hsa001000.60480501
116Insulin secretion_Homo sapiens_hsa049110.59911462
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58348610
118Herpes simplex infection_Homo sapiens_hsa051680.57425644
119Hepatitis B_Homo sapiens_hsa051610.56524866
120Influenza A_Homo sapiens_hsa051640.56022243
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55372887
122Salmonella infection_Homo sapiens_hsa051320.55162541
123Proteoglycans in cancer_Homo sapiens_hsa052050.54819825
124Wnt signaling pathway_Homo sapiens_hsa043100.54589826

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