FYTTD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.87834369
2cilium or flagellum-dependent cell motility (GO:0001539)6.84473688
3male meiosis (GO:0007140)6.27562974
4synaptonemal complex organization (GO:0070193)6.02589547
5DNA methylation involved in gamete generation (GO:0043046)5.75132809
6synaptonemal complex assembly (GO:0007130)5.72801975
7regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.22306520
8regulation of DNA endoreduplication (GO:0032875)4.80654287
9regulation of meiosis I (GO:0060631)4.17004674
10interleukin-6-mediated signaling pathway (GO:0070102)4.16028771
11meiotic nuclear division (GO:0007126)4.15906705
12acrosome assembly (GO:0001675)4.13529525
13COPII vesicle coating (GO:0048208)4.08038110
14chromosome organization involved in meiosis (GO:0070192)4.07259761
15ER overload response (GO:0006983)4.05210747
16positive regulation of mitochondrial fission (GO:0090141)4.01632311
17male meiosis I (GO:0007141)4.01409133
18fusion of sperm to egg plasma membrane (GO:0007342)3.95322926
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.88284132
20actin-myosin filament sliding (GO:0033275)3.84348115
21muscle filament sliding (GO:0030049)3.84348115
22epithelial cilium movement (GO:0003351)3.81987074
23gonadal mesoderm development (GO:0007506)3.73959544
24sperm motility (GO:0030317)3.71700148
25spermatid development (GO:0007286)3.67793073
26axonemal dynein complex assembly (GO:0070286)3.65964250
27binding of sperm to zona pellucida (GO:0007339)3.54308052
28sperm-egg recognition (GO:0035036)3.49827232
29snRNA transcription (GO:0009301)3.49597732
30cilium movement (GO:0003341)3.46679597
31regulation of skeletal muscle contraction (GO:0014819)3.42857484
32ribonucleoprotein complex disassembly (GO:0032988)3.41933433
33monoubiquitinated protein deubiquitination (GO:0035520)3.41898744
34plasma membrane fusion (GO:0045026)3.39173011
35definitive hemopoiesis (GO:0060216)3.33407682
36intraciliary transport (GO:0042073)3.32973346
37protein K11-linked deubiquitination (GO:0035871)3.32176762
38negative regulation of glucose import (GO:0046325)3.31171731
39positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30771759
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.30771759
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30771759
42gene silencing by RNA (GO:0031047)3.30222681
43positive regulation of translational initiation (GO:0045948)3.29915951
44regulation of relaxation of muscle (GO:1901077)3.27835001
45skeletal muscle contraction (GO:0003009)3.26199816
46actin-mediated cell contraction (GO:0070252)3.25906861
47regulation of sarcomere organization (GO:0060297)3.25454144
48sarcoplasmic reticulum calcium ion transport (GO:0070296)3.25401609
49nuclear pore complex assembly (GO:0051292)3.22364554
50mitotic sister chromatid cohesion (GO:0007064)3.21193005
51nuclear pore organization (GO:0006999)3.19268096
52intra-Golgi vesicle-mediated transport (GO:0006891)3.14349835
53regulation of fibroblast apoptotic process (GO:2000269)3.13728786
54meiosis I (GO:0007127)3.12011420
55lipid particle organization (GO:0034389)3.05019041
56nerve growth factor signaling pathway (GO:0038180)3.04317275
57sarcomere organization (GO:0045214)3.03192458
58regulation of cilium movement (GO:0003352)3.03192374
59positive regulation of protein autophosphorylation (GO:0031954)3.02738682
60acrosome reaction (GO:0007340)3.02356787
61cellular response to ethanol (GO:0071361)2.99067929
62signal peptide processing (GO:0006465)2.97050893
63meiotic chromosome segregation (GO:0045132)2.95701769
64regulation of glucokinase activity (GO:0033131)2.93040720
65regulation of hexokinase activity (GO:1903299)2.93040720
66regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.92575382
67cell-cell recognition (GO:0009988)2.92184348
68DNA double-strand break processing (GO:0000729)2.89932725
69positive regulation of meiosis (GO:0045836)2.89654203
70endoplasmic reticulum organization (GO:0007029)2.89449056
71short-chain fatty acid metabolic process (GO:0046459)2.89324788
72negative regulation of DNA repair (GO:0045738)2.88395430
73negative regulation of organelle assembly (GO:1902116)2.86941034
74protein localization to cilium (GO:0061512)2.86872019
75regulation of energy homeostasis (GO:2000505)2.86195489
76inositol phosphate catabolic process (GO:0071545)2.84346557
77inositol metabolic process (GO:0006020)2.83440303
78succinate metabolic process (GO:0006105)2.83200701
79histone H2A ubiquitination (GO:0033522)2.81474838
80ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.80022231
81regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.79411298
82germ cell development (GO:0007281)2.79099809
83regulation of centriole replication (GO:0046599)2.76255157
84cellular response to antibiotic (GO:0071236)2.74207714
85establishment of protein localization to Golgi (GO:0072600)2.73941674
86keratinocyte development (GO:0003334)2.73865774
87negative regulation of glucose transport (GO:0010829)2.72704827
88negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.71833864
89retrograde transport, vesicle recycling within Golgi (GO:0000301)2.71724756
90inositol phosphate dephosphorylation (GO:0046855)2.70972707
91phosphorylated carbohydrate dephosphorylation (GO:0046838)2.70972707
92magnesium ion transport (GO:0015693)2.70658474
93organelle disassembly (GO:1903008)2.69966786
94innervation (GO:0060384)2.68022501
95ER to Golgi vesicle-mediated transport (GO:0006888)2.67757621
96meiotic cell cycle process (GO:1903046)2.67014451
97sphingosine metabolic process (GO:0006670)2.66677146
98Rap protein signal transduction (GO:0032486)2.64969654
99positive regulation of meiotic cell cycle (GO:0051446)2.64150898
100sister chromatid cohesion (GO:0007062)2.63981619
101labyrinthine layer development (GO:0060711)2.63205965
102peroxisome fission (GO:0016559)2.62777210
103nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.61670264
104RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.60352724
105UDP-N-acetylglucosamine metabolic process (GO:0006047)2.60208321
106positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.59721693
107regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.59721693
108regulation of acyl-CoA biosynthetic process (GO:0050812)2.58757377
109protein K6-linked ubiquitination (GO:0085020)2.58660252
110response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.56514917
111carnitine shuttle (GO:0006853)2.55695714
112COPI coating of Golgi vesicle (GO:0048205)2.55456320
113Golgi transport vesicle coating (GO:0048200)2.55456320
114muscle organ morphogenesis (GO:0048644)2.54244290
115positive regulation of glycolytic process (GO:0045821)2.53867447
116response to inactivity (GO:0014854)2.53718701
117motile cilium assembly (GO:0044458)2.53657244
118Golgi to endosome transport (GO:0006895)2.53237454
119negative regulation of neurotransmitter secretion (GO:0046929)2.53099192
120spermatogenesis (GO:0007283)2.53089761
121male gamete generation (GO:0048232)2.53076091
122DNA alkylation (GO:0006305)2.52403264
123DNA methylation (GO:0006306)2.52403264
124cellular response to glucose starvation (GO:0042149)2.52220261
125negative regulation of NF-kappaB import into nucleus (GO:0042347)2.51035344
126calcium ion-dependent exocytosis (GO:0017156)2.48452902
127protein K63-linked deubiquitination (GO:0070536)2.47946715
128microtubule severing (GO:0051013)2.47818818
129cellular process involved in reproduction in multicellular organism (GO:0022412)2.46755239
130multicellular organism reproduction (GO:0032504)2.45806951
131regulation of protein polyubiquitination (GO:1902914)2.40195946
132layer formation in cerebral cortex (GO:0021819)2.39097713
133resolution of meiotic recombination intermediates (GO:0000712)2.37997935
134ventricular system development (GO:0021591)2.37704204
135negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.36860276
136regulation of RNA export from nucleus (GO:0046831)2.34601471
137chaperone-mediated protein complex assembly (GO:0051131)2.34085519
138meiotic cell cycle (GO:0051321)2.33824982
139regulation of short-term neuronal synaptic plasticity (GO:0048172)2.33715734
140seminiferous tubule development (GO:0072520)2.33256648
141synaptic vesicle docking involved in exocytosis (GO:0016081)2.31769854
142microtubule-based movement (GO:0007018)2.30481440
143gamete generation (GO:0007276)2.30213190
144regulation of synaptic vesicle exocytosis (GO:2000300)2.27268348
145genitalia morphogenesis (GO:0035112)2.27003965
146regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.26295914
147regulation of microtubule-based movement (GO:0060632)2.24935420
148positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.24827012
149negative regulation of inclusion body assembly (GO:0090084)2.24147474
150peptidyl-lysine dimethylation (GO:0018027)2.23779109
151synaptic vesicle exocytosis (GO:0016079)2.21254841
152synapsis (GO:0007129)2.21053735
153pore complex assembly (GO:0046931)2.19840702
154vesicle transport along microtubule (GO:0047496)2.17273967
155cilium morphogenesis (GO:0060271)2.16868643
156axon extension (GO:0048675)2.16574707
157histone H2A acetylation (GO:0043968)2.15438758
158cullin deneddylation (GO:0010388)2.14031446
159lactate metabolic process (GO:0006089)2.13286357
160positive regulation of male gonad development (GO:2000020)2.12836523
161microtubule depolymerization (GO:0007019)2.11893581
162sex differentiation (GO:0007548)2.10828664
163establishment of nucleus localization (GO:0040023)2.10349447
164cell wall macromolecule catabolic process (GO:0016998)2.10123323
165cell wall macromolecule metabolic process (GO:0044036)2.10123323
166regulation of potassium ion transmembrane transporter activity (GO:1901016)2.07899022
167cell recognition (GO:0008037)2.07855436
168gene silencing (GO:0016458)2.06676229
169fertilization (GO:0009566)2.05744840
170protein localization to synapse (GO:0035418)2.05453435
171glutamate secretion (GO:0014047)2.05235065
172DNA methylation or demethylation (GO:0044728)2.04918148
173positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.04538224
174protein targeting to Golgi (GO:0000042)2.01931136
175body morphogenesis (GO:0010171)2.00893078
176cilium organization (GO:0044782)2.00877221
177axoneme assembly (GO:0035082)2.00753954
178neuron cell-cell adhesion (GO:0007158)2.00211838
179nucleus localization (GO:0051647)1.98913135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.65629617
2EZH2_22144423_ChIP-Seq_EOC_Human4.64024223
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.01591161
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.90181681
5ZNF274_21170338_ChIP-Seq_K562_Hela2.82804580
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.76923766
7ELK1_19687146_ChIP-ChIP_HELA_Human2.49925948
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48051197
9FUS_26573619_Chip-Seq_HEK293_Human2.29663719
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19566320
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.18083662
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15654804
13GBX2_23144817_ChIP-Seq_PC3_Human2.15009690
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.12522759
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08653515
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.06092988
17TAF15_26573619_Chip-Seq_HEK293_Human2.04380659
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97781859
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86999735
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.82360718
21RNF2_27304074_Chip-Seq_NSC_Mouse1.81795760
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75183219
23* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74726151
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71993778
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71981462
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.71886869
27VDR_23849224_ChIP-Seq_CD4+_Human1.70929831
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69017597
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.68389771
30SMAD4_21799915_ChIP-Seq_A2780_Human1.62206802
31RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.60691737
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60501603
33EWS_26573619_Chip-Seq_HEK293_Human1.60102964
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57432463
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57432463
36P300_19829295_ChIP-Seq_ESCs_Human1.56313422
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.55338223
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.53781376
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53725062
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53191425
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52888943
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52120812
43GATA1_22025678_ChIP-Seq_K562_Human1.50511623
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49651180
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49079499
46* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47068906
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46456473
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.46252061
49* ER_23166858_ChIP-Seq_MCF-7_Human1.46045087
50* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.44237230
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.40859770
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40796553
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40508171
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39578787
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37788019
56BCAT_22108803_ChIP-Seq_LS180_Human1.36110749
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36087791
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35594413
59VDR_22108803_ChIP-Seq_LS180_Human1.34476100
60TFEB_21752829_ChIP-Seq_HELA_Human1.33807211
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33356256
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.31959693
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30710193
64CBP_20019798_ChIP-Seq_JUKART_Human1.30710193
65STAT3_23295773_ChIP-Seq_U87_Human1.29275299
66TCF4_23295773_ChIP-Seq_U87_Human1.28678618
67SOX9_26525672_Chip-Seq_HEART_Mouse1.27564657
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26935765
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26103809
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.25655911
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25640848
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25509787
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25133562
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.24060560
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.21786222
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.20916891
77REST_21632747_ChIP-Seq_MESCs_Mouse1.20258419
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.20040887
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18939141
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18557835
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17572917
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17572917
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17553855
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.17475246
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17250747
86BRD4_25478319_ChIP-Seq_HGPS_Human1.16457274
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16319584
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.16277005
89CDX2_22108803_ChIP-Seq_LS180_Human1.15079598
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15029022
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14714691
92IGF1R_20145208_ChIP-Seq_DFB_Human1.13598115
93* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13499323
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13458730
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12303182
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12152873
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11504636
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11160018
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.09472854
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09288800
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08588435
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08426176
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.08114980
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07973345
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07665308
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06671085
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06621409
108TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06119021
109ELF5_23300383_ChIP-Seq_T47D_Human1.05956652
110NMYC_18555785_Chip-Seq_ESCs_Mouse1.05590182
111GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05255820
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04932489
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04731449
114* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04253987
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.03975936
116OCT4_18555785_Chip-Seq_ESCs_Mouse1.03385610
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.03096020
118* DCP1A_22483619_ChIP-Seq_HELA_Human1.03034703
119P300_18555785_Chip-Seq_ESCs_Mouse1.02682457
120RUNX2_22187159_ChIP-Seq_PCA_Human1.02446965
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.02408946
122REST_19997604_ChIP-ChIP_NEURONS_Mouse1.01980803
123SALL4_22934838_ChIP-ChIP_CD34+_Human1.01744346
124SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01289581
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01007957
126IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00993099
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00524065
128TCF4_22108803_ChIP-Seq_LS180_Human1.00272041
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00235587
130YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00102237
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99819753
132P53_22387025_ChIP-Seq_ESCs_Mouse0.99552699
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.99181545
134CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99099218
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98076918
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.97382240
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96501980
138JUN_21703547_ChIP-Seq_K562_Human0.95105086
139POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94839256
140CMYC_18555785_Chip-Seq_ESCs_Mouse0.93991554
141AR_21572438_ChIP-Seq_LNCaP_Human0.93760767
142PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93366347
143ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92423416
144TP53_16413492_ChIP-PET_HCT116_Human0.92256953
145SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91256818
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.90604208
147AR_25329375_ChIP-Seq_VCAP_Human0.90597376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.24031495
2MP0003646_muscle_fatigue3.42854173
3MP0005410_abnormal_fertilization3.01314120
4MP0003123_paternal_imprinting2.63685815
5MP0003950_abnormal_plasma_membrane2.63088258
6MP0003122_maternal_imprinting2.59627759
7MP0002009_preneoplasia2.50324208
8MP0000015_abnormal_ear_pigmentation2.28849075
9MP0003121_genomic_imprinting2.24676872
10MP0003698_abnormal_male_reproductive2.18725674
11MP0005623_abnormal_meninges_morphology2.16847772
12MP0003221_abnormal_cardiomyocyte_apopto2.15502116
13MP0003656_abnormal_erythrocyte_physiolo2.09075901
14MP0002210_abnormal_sex_determination2.02415414
15MP0000537_abnormal_urethra_morphology2.00358145
16MP0001929_abnormal_gametogenesis1.99862812
17MP0010678_abnormal_skin_adnexa1.99390989
18MP0004145_abnormal_muscle_electrophysio1.99078374
19MP0002102_abnormal_ear_morphology1.95069483
20MP0003045_fibrosis1.92445935
21MP0002877_abnormal_melanocyte_morpholog1.88336132
22MP0002332_abnormal_exercise_endurance1.88263444
23MP0003787_abnormal_imprinting1.80038884
24MP0005379_endocrine/exocrine_gland_phen1.79493024
25MP0004859_abnormal_synaptic_plasticity1.76770123
26MP0004233_abnormal_muscle_weight1.72106948
27MP0004270_analgesia1.71043765
28MP0001529_abnormal_vocalization1.69139567
29MP0000751_myopathy1.67050746
30MP0003880_abnormal_central_pattern1.66239018
31MP0001145_abnormal_male_reproductive1.63147147
32MP0004808_abnormal_hematopoietic_stem1.61259768
33MP0000372_irregular_coat_pigmentation1.59657092
34MP0004084_abnormal_cardiac_muscle1.59393680
35MP0005187_abnormal_penis_morphology1.56303325
36MP0000383_abnormal_hair_follicle1.52852702
37MP0002269_muscular_atrophy1.51703293
38MP0002837_dystrophic_cardiac_calcinosis1.50629057
39MP0002166_altered_tumor_susceptibility1.50250058
40MP0005075_abnormal_melanosome_morpholog1.49950841
41MP0004215_abnormal_myocardial_fiber1.45098171
42MP0003635_abnormal_synaptic_transmissio1.45045816
43MP0009780_abnormal_chondrocyte_physiolo1.43180624
44MP0000653_abnormal_sex_gland1.41058866
45MP0000013_abnormal_adipose_tissue1.39763625
46MP0004272_abnormal_basement_membrane1.39434576
47MP0000759_abnormal_skeletal_muscle1.39149014
48MP0005330_cardiomyopathy1.36738709
49MP0000778_abnormal_nervous_system1.36304110
50MP0002972_abnormal_cardiac_muscle1.36261791
51MP0001299_abnormal_eye_distance/1.34890492
52MP0004484_altered_response_of1.33256785
53MP0002095_abnormal_skin_pigmentation1.30447443
54MP0001727_abnormal_embryo_implantation1.29800271
55MP0002063_abnormal_learning/memory/cond1.29622120
56MP0004134_abnormal_chest_morphology1.29574751
57MP0004036_abnormal_muscle_relaxation1.25391550
58MP0009046_muscle_twitch1.22585639
59MP0002160_abnormal_reproductive_system1.22155705
60MP0002282_abnormal_trachea_morphology1.21701665
61MP0008995_early_reproductive_senescence1.21535828
62MP0004130_abnormal_muscle_cell1.21132072
63MP0005503_abnormal_tendon_morphology1.18868452
64MP0002127_abnormal_cardiovascular_syste1.18445334
65MP0000733_abnormal_muscle_development1.16889355
66MP0010352_gastrointestinal_tract_polyps1.16658149
67MP0002184_abnormal_innervation1.16398011
68MP0003763_abnormal_thymus_physiology1.15854827
69MP0005266_abnormal_metabolism1.15757476
70MP0006276_abnormal_autonomic_nervous1.14163536
71MP0003890_abnormal_embryonic-extraembry1.14077528
72MP0002161_abnormal_fertility/fecundity1.13782095
73MP0003385_abnormal_body_wall1.12215960
74MP0005174_abnormal_tail_pigmentation1.12001959
75MP0002734_abnormal_mechanical_nocicepti1.11831389
76MP0002108_abnormal_muscle_morphology1.11207572
77MP0005645_abnormal_hypothalamus_physiol1.10789495
78MP0000427_abnormal_hair_cycle1.10589942
79MP0008057_abnormal_DNA_replication1.10473136
80MP0005423_abnormal_somatic_nervous1.10368165
81MP0006036_abnormal_mitochondrial_physio1.10248856
82MP0000569_abnormal_digit_pigmentation1.09281856
83MP0001879_abnormal_lymphatic_vessel1.08987733
84MP0000747_muscle_weakness1.08656430
85MP0010234_abnormal_vibrissa_follicle1.07642022
86MP0006072_abnormal_retinal_apoptosis1.07604779
87MP0005551_abnormal_eye_electrophysiolog1.07006870
88MP0009745_abnormal_behavioral_response1.05652121
89MP0001191_abnormal_skin_condition1.05380627
90MP0000749_muscle_degeneration1.04811119
91MP0001661_extended_life_span1.04346414
92MP0001188_hyperpigmentation1.02851108
93MP0009697_abnormal_copulation1.01870064
94MP0000371_diluted_coat_color1.01214256
95MP0003567_abnormal_fetal_cardiomyocyte1.00677689
96MP0009250_abnormal_appendicular_skeleto0.99812004
97MP0002163_abnormal_gland_morphology0.99795700
98MP0005620_abnormal_muscle_contractility0.99622959
99MP0001984_abnormal_olfaction0.99057624
100MP0008775_abnormal_heart_ventricle0.98414259
101MP0002572_abnormal_emotion/affect_behav0.97771174
102MP0001968_abnormal_touch/_nociception0.97029202
103MP0010307_abnormal_tumor_latency0.97023137
104MP0003942_abnormal_urinary_system0.96272509
105MP0002106_abnormal_muscle_physiology0.95043604
106MP0002006_tumorigenesis0.94008409
107MP0003941_abnormal_skin_development0.93025913
108MP0003937_abnormal_limbs/digits/tail_de0.92827597
109MP0003861_abnormal_nervous_system0.91668659
110MP0005253_abnormal_eye_physiology0.91015998
111MP0001440_abnormal_grooming_behavior0.90866999
112MP0004811_abnormal_neuron_physiology0.90332052
113MP0005369_muscle_phenotype0.90102768
114MP0002234_abnormal_pharynx_morphology0.89663342
115MP0010094_abnormal_chromosome_stability0.89487770
116MP0008058_abnormal_DNA_repair0.88641615
117MP0002084_abnormal_developmental_patter0.86687924
118MP0002557_abnormal_social/conspecific_i0.86660712
119MP0002751_abnormal_autonomic_nervous0.86635212
120MP0000631_abnormal_neuroendocrine_gland0.86061108
121MP0005171_absent_coat_pigmentation0.85539888
122MP0010386_abnormal_urinary_bladder0.85417430
123MP0004085_abnormal_heartbeat0.84819087
124MP0001919_abnormal_reproductive_system0.84643640
125MP0002067_abnormal_sensory_capabilities0.84428282
126MP0002736_abnormal_nociception_after0.84184773
127MP0000377_abnormal_hair_follicle0.83290599
128MP0004197_abnormal_fetal_growth/weight/0.82237107
129MP0002152_abnormal_brain_morphology0.82158776
130MP0003786_premature_aging0.81454888
131MP0000750_abnormal_muscle_regeneration0.81312489
132MP0005275_abnormal_skin_tensile0.79682753
133MP0003315_abnormal_perineum_morphology0.79511855
134MP0003943_abnormal_hepatobiliary_system0.79233059
135MP0002064_seizures0.78443433
136MP0003755_abnormal_palate_morphology0.77780461
137MP0004087_abnormal_muscle_fiber0.77514546
138MP0001177_atelectasis0.77448088
139MP0002735_abnormal_chemical_nociception0.77339972
140MP0003119_abnormal_digestive_system0.76414710
141MP0003137_abnormal_impulse_conducting0.76393988
142MP0002233_abnormal_nose_morphology0.75867014
143MP0004924_abnormal_behavior0.75381409
144MP0005386_behavior/neurological_phenoty0.75381409
145MP0003183_abnormal_peptide_metabolism0.74915269
146MP0002653_abnormal_ependyma_morphology0.74832626
147MP0005389_reproductive_system_phenotype0.74253780
148MP0002882_abnormal_neuron_morphology0.74163200
149MP0005385_cardiovascular_system_phenoty0.73148780
150MP0001544_abnormal_cardiovascular_syste0.73148780
151MP0008007_abnormal_cellular_replicative0.73061182
152MP0002272_abnormal_nervous_system0.72759344
153MP0000647_abnormal_sebaceous_gland0.71780622
154MP0002177_abnormal_outer_ear0.70536528
155MP0001835_abnormal_antigen_presentation0.69239818
156MP0001216_abnormal_epidermal_layer0.67698698
157MP0002168_other_aberrant_phenotype0.67532300
158MP0002693_abnormal_pancreas_physiology0.67505272
159MP0001944_abnormal_pancreas_morphology0.66818132
160MP0002075_abnormal_coat/hair_pigmentati0.64320672
161MP0003868_abnormal_feces_composition0.63879815
162MP0000465_gastrointestinal_hemorrhage0.60826671
163MP0000627_abnormal_mammary_gland0.60232374
164MP0006035_abnormal_mitochondrial_morpho0.58621040
165MP0000358_abnormal_cell_content/0.58545595

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.68706833
2Absent/shortened dynein arms (HP:0200106)4.25917878
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.25917878
4Gonadotropin excess (HP:0000837)3.43662709
5Abnormal respiratory motile cilium physiology (HP:0012261)3.37792151
6Curly hair (HP:0002212)3.30809691
7Abnormality of the lower motor neuron (HP:0002366)3.28005141
8Distal arthrogryposis (HP:0005684)3.24370108
9Myoglobinuria (HP:0002913)3.18569322
10Shoulder girdle muscle weakness (HP:0003547)3.15954783
11Abnormal respiratory epithelium morphology (HP:0012253)3.02366248
12Abnormal respiratory motile cilium morphology (HP:0005938)3.02366248
13Cutaneous melanoma (HP:0012056)2.98551939
14Abnormality of the left ventricular outflow tract (HP:0011103)2.98451204
15Subaortic stenosis (HP:0001682)2.98451204
16Horizontal nystagmus (HP:0000666)2.95355448
17Rhinitis (HP:0012384)2.93205467
18Abnormal protein glycosylation (HP:0012346)2.91434775
19Abnormal glycosylation (HP:0012345)2.91434775
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.91434775
21Abnormal protein N-linked glycosylation (HP:0012347)2.91434775
22Reduced antithrombin III activity (HP:0001976)2.91253027
23Hyporeflexia of lower limbs (HP:0002600)2.77629924
24Nephronophthisis (HP:0000090)2.73055243
25Fibular hypoplasia (HP:0003038)2.72163020
26Abnormal ciliary motility (HP:0012262)2.70618003
27Rhabdomyolysis (HP:0003201)2.68120919
28EMG: myopathic abnormalities (HP:0003458)2.66593621
29Bundle branch block (HP:0011710)2.63350931
30Papillary thyroid carcinoma (HP:0002895)2.61783259
31Cystic hygroma (HP:0000476)2.58623909
32Amyotrophic lateral sclerosis (HP:0007354)2.58246258
33Neck muscle weakness (HP:0000467)2.54981082
34Volvulus (HP:0002580)2.52888791
35Frequent falls (HP:0002359)2.52434739
36Albinism (HP:0001022)2.46580069
37Hypokinesia (HP:0002375)2.43923373
38Medial flaring of the eyebrow (HP:0010747)2.40752525
39Type I transferrin isoform profile (HP:0003642)2.38864277
40Infertility (HP:0000789)2.37089772
4111 pairs of ribs (HP:0000878)2.36929400
42Azoospermia (HP:0000027)2.33709100
43Absent phalangeal crease (HP:0006109)2.33671711
44Microglossia (HP:0000171)2.32336756
45Abnormal spermatogenesis (HP:0008669)2.30944432
46Pelvic girdle muscle weakness (HP:0003749)2.30256868
47Renal cortical cysts (HP:0000803)2.25761170
48Gait imbalance (HP:0002141)2.24450378
49Aplasia/Hypoplasia of the fibula (HP:0006492)2.22377442
50Abnormality of the musculature of the pelvis (HP:0001469)2.20649212
51Abnormality of the hip-girdle musculature (HP:0001445)2.20649212
52Exercise-induced myalgia (HP:0003738)2.16965505
53Type 1 muscle fiber predominance (HP:0003803)2.13084297
54Deep philtrum (HP:0002002)2.12694190
55Metaphyseal dysplasia (HP:0100255)2.11826525
56Exercise-induced muscle cramps (HP:0003710)2.08084315
57Limb-girdle muscle weakness (HP:0003325)2.08051723
58Congenital primary aphakia (HP:0007707)2.06740616
59Abnormality of dentin (HP:0010299)2.05764800
60Chronic bronchitis (HP:0004469)2.05564993
61Bell-shaped thorax (HP:0001591)2.05035519
62Long clavicles (HP:0000890)2.04875540
63Nemaline bodies (HP:0003798)2.04239753
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.03571633
65Rimmed vacuoles (HP:0003805)2.03497215
66Exocrine pancreatic insufficiency (HP:0001738)1.99591789
67Muscle fiber inclusion bodies (HP:0100299)1.99109488
68Fair hair (HP:0002286)1.98713102
69EMG: neuropathic changes (HP:0003445)1.97362939
70Septate vagina (HP:0001153)1.96950242
71Freckling (HP:0001480)1.96925566
72Scotoma (HP:0000575)1.96812044
73Conjunctival hamartoma (HP:0100780)1.96566695
74Muscle hypertrophy of the lower extremities (HP:0008968)1.95874756
75Abnormality of the calf musculature (HP:0001430)1.95619631
76Meningioma (HP:0002858)1.95310778
77Melanoma (HP:0002861)1.94208035
78Progressive inability to walk (HP:0002505)1.92879448
79Absent eyebrow (HP:0002223)1.92000301
80Abnormality of midbrain morphology (HP:0002418)1.91810723
81Molar tooth sign on MRI (HP:0002419)1.91810723
82Areflexia of lower limbs (HP:0002522)1.91660859
83Atonic seizures (HP:0010819)1.91601686
84Methylmalonic acidemia (HP:0002912)1.90028453
85Missing ribs (HP:0000921)1.89086081
86Abnormality of the renal medulla (HP:0100957)1.89057950
87Calf muscle hypertrophy (HP:0008981)1.88936985
88Proximal tubulopathy (HP:0000114)1.88716186
89Progressive cerebellar ataxia (HP:0002073)1.87951953
90Gaze-evoked nystagmus (HP:0000640)1.86975871
91Genital tract atresia (HP:0001827)1.86837798
92Abnormality of the renal cortex (HP:0011035)1.86335488
93Hamartoma of the eye (HP:0010568)1.86209866
94Abnormal finger flexion creases (HP:0006143)1.84451893
95Diminished movement (HP:0002374)1.84173901
96Abnormality of methionine metabolism (HP:0010901)1.82442889
97Supernumerary spleens (HP:0009799)1.81215917
98Central scotoma (HP:0000603)1.79405535
99Sudden death (HP:0001699)1.79039280
100Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78562194
101Hypoplasia of the brainstem (HP:0002365)1.78562194
102Vaginal atresia (HP:0000148)1.77501018
103Relative macrocephaly (HP:0004482)1.77456066
104Hypoplastic ischia (HP:0003175)1.73184822
105Nephrogenic diabetes insipidus (HP:0009806)1.73083225
106Hypoproteinemia (HP:0003075)1.71250917
107Abnormality of macular pigmentation (HP:0008002)1.71228296
108Thyroid carcinoma (HP:0002890)1.69533890
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69280704
110Degeneration of the lateral corticospinal tracts (HP:0002314)1.69280704
111Neonatal respiratory distress (HP:0002643)1.68807231
112Difficulty climbing stairs (HP:0003551)1.68724186
113Poor coordination (HP:0002370)1.67239250
114Delayed gross motor development (HP:0002194)1.64896123
115Urinary urgency (HP:0000012)1.64741517
116Epileptic encephalopathy (HP:0200134)1.63903072
117Drooling (HP:0002307)1.63800635
118Excessive salivation (HP:0003781)1.63800635
119Congenital stationary night blindness (HP:0007642)1.62644435
120Pheochromocytoma (HP:0002666)1.62346353
121Type II lissencephaly (HP:0007260)1.62060054
122Breast carcinoma (HP:0003002)1.62033311
123Buphthalmos (HP:0000557)1.61913002
124Proximal amyotrophy (HP:0007126)1.61868915
125Abnormality of vitamin B metabolism (HP:0004340)1.61441327
126Vitreoretinal degeneration (HP:0000655)1.60520457
127Postaxial hand polydactyly (HP:0001162)1.60356175
128Facial cleft (HP:0002006)1.60210227
129Acute myeloid leukemia (HP:0004808)1.58764885
130Hypothermia (HP:0002045)1.58528338
131Scapular winging (HP:0003691)1.58123721
132Dental crowding (HP:0000678)1.57681458
133Fetal akinesia sequence (HP:0001989)1.57650068
134Inability to walk (HP:0002540)1.57618310
135Subacute progressive viral hepatitis (HP:0006572)1.56967799
136Abnormality of the vitamin B12 metabolism (HP:0004341)1.56478102
137Abnormality of the labia minora (HP:0012880)1.56133909
138Focal motor seizures (HP:0011153)1.55752899
139Lissencephaly (HP:0001339)1.55279570
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.55043905
141Facial diplegia (HP:0001349)1.55009013
142Fatigable weakness (HP:0003473)1.54800962
143Abnormality of the neuromuscular junction (HP:0003398)1.54800962
144Colon cancer (HP:0003003)1.54538582
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.54351100
146Short ribs (HP:0000773)1.53897972
147Limb-girdle muscle atrophy (HP:0003797)1.53616466
148Autoamputation (HP:0001218)1.53107067
149Postaxial foot polydactyly (HP:0001830)1.51862358
150Occipital encephalocele (HP:0002085)1.51761106
151Atrophy/Degeneration involving motor neurons (HP:0007373)1.51710728
152Menstrual irregularities (HP:0000858)1.51483612
153Termporal pattern (HP:0011008)1.51136651
154Insidious onset (HP:0003587)1.51136651
155Abnormality of the intrinsic pathway (HP:0010989)1.50859194
156Bifid tongue (HP:0010297)1.50098909
157Generalized hypopigmentation of hair (HP:0011358)1.50060296
158Retinal dysplasia (HP:0007973)1.49961867
159Abnormality of chromosome stability (HP:0003220)1.49410304
160Neuroendocrine neoplasm (HP:0100634)1.48949003
161Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.48908253
162Pachygyria (HP:0001302)1.48837384
163Abnormality of the shoulder girdle musculature (HP:0001435)1.47815928
164Follicular hyperkeratosis (HP:0007502)1.47208207
165Tongue fasciculations (HP:0001308)1.46110466
166Hematochezia (HP:0002573)1.46092328
167Thyroiditis (HP:0100646)1.45997978
168Abnormality of the ischium (HP:0003174)1.45974164
169Selective tooth agenesis (HP:0001592)1.45891631
170Embryonal renal neoplasm (HP:0011794)1.45814106
171Biliary tract neoplasm (HP:0100574)1.45263799
172Absent frontal sinuses (HP:0002688)1.45015566
173Tubular atrophy (HP:0000092)1.44645226
174Abnormality of the anterior horn cell (HP:0006802)1.44613267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.49197316
2PDK35.49197316
3EIF2AK33.96417558
4PDK23.47182267
5CAMKK22.53885372
6PIK3CG2.51498936
7MARK12.36666137
8PNCK2.18540579
9CDC72.18212401
10MAP3K42.16957927
11MST42.11053957
12MUSK2.09974579
13PLK22.03938601
14PRKD32.02001706
15TRIM281.95973392
16NEK11.94958933
17ERBB31.93169465
18ACVR1B1.92529632
19MAP3K141.82426466
20NTRK31.82365557
21KSR11.78130240
22FER1.72920326
23BCR1.72548023
24BMPR21.71466174
25TESK11.70515807
26NEK91.60897254
27CCNB11.58629276
28MINK11.50942096
29FLT31.50719348
30MAP2K71.48911567
31AKT31.48433879
32MAP4K21.46485510
33OBSCN1.37586263
34MET1.36538049
35PLK31.27747359
36WNK41.25663891
37PTK2B1.21191216
38STK391.20407150
39CASK1.19143022
40SCYL21.17755242
41MAPK131.17592206
42WNK31.17513512
43TRPM71.16903309
44LIMK11.11245722
45MAPKAPK31.07330333
46PINK11.06395268
47STK38L1.06331176
48FRK1.05174069
49MAP2K41.03308346
50SIK31.02134402
51BMPR1B1.00532316
52STK240.97946440
53JAK10.97846726
54EIF2AK20.97398455
55PAK30.95335243
56IKBKE0.86476558
57TAOK30.86134216
58BRSK20.85640620
59NTRK20.85635663
60TEC0.85306575
61WNK10.84871976
62IRAK10.81015443
63CSNK1G20.80734994
64NEK20.80070393
65FGFR10.79257877
66WEE10.76912537
67PKN20.75541824
68RPS6KB20.75225874
69MAP3K50.75085476
70PHKG10.74754981
71PHKG20.74754981
72CDK60.73162381
73DYRK1A0.70859528
74PRPF4B0.69585901
75PASK0.67905913
76MAPKAPK50.66900876
77MAP2K60.66777490
78CSNK1A1L0.66465398
79CLK10.62946881
80STK30.62697411
81EPHA30.59797874
82SRPK10.59758185
83CDK140.59415815
84TGFBR10.59102284
85PRKCG0.58966539
86PAK60.58347718
87BRD40.57731681
88SGK20.56623525
89ABL10.55486180
90RPS6KB10.55482863
91DDR20.55064074
92INSRR0.54784399
93MKNK20.54744080
94ATM0.54438567
95CDC42BPA0.54157131
96YES10.53578713
97MKNK10.53531568
98EPHA40.53132851
99TAOK20.51234283
100PLK40.50456610
101ICK0.50043787
102TTK0.49228845
103DYRK30.48951513
104PRKAA10.48807945
105IGF1R0.47975574
106PIK3CA0.47788529
107PBK0.47125801
108NME10.47087981
109CDK50.46664007
110MAP3K120.46262432
111LATS10.45797941
112* CHEK10.45667369
113CHEK20.45327099
114NEK60.45248670
115TTN0.44266031
116PLK10.43803648
117CAMK2A0.43514683
118CDK180.43507454
119CHUK0.42633006
120TBK10.42584359
121TYK20.41982037
122IKBKB0.41765986
123TSSK60.41697266
124CSNK1G30.41176127
125BRSK10.40687868
126CDK80.40500372
127ADRBK20.40132940
128MAP3K20.40110094
129ATR0.39698679
130PRKAA20.39258230
131PRKCE0.38950596
132MAP2K10.38202412
133RET0.38067299
134UHMK10.37829721
135EIF2AK10.37664993
136KIT0.37153388
137PRKDC0.36868755
138CDK10.36381360
139CDK150.36379990
140CSNK1G10.35823092
141MAPK100.35815094
142SGK2230.35783057
143SGK4940.35783057
144SGK10.35219808
145MYLK0.31327348
146CSF1R0.30777943
147MELK0.30072767
148IRAK20.29483301
149EGFR0.27059199

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of autophagy_Homo sapiens_hsa041402.43715687
2Oocyte meiosis_Homo sapiens_hsa041142.18522023
3Nicotine addiction_Homo sapiens_hsa050332.17218147
4Non-homologous end-joining_Homo sapiens_hsa034502.10586823
5Phototransduction_Homo sapiens_hsa047442.09724596
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.02291896
7Long-term potentiation_Homo sapiens_hsa047201.94334560
8Synaptic vesicle cycle_Homo sapiens_hsa047211.94022422
9Amphetamine addiction_Homo sapiens_hsa050311.76754811
10Selenocompound metabolism_Homo sapiens_hsa004501.75839462
11Dopaminergic synapse_Homo sapiens_hsa047281.72041523
12Cardiac muscle contraction_Homo sapiens_hsa042601.71536565
13Butanoate metabolism_Homo sapiens_hsa006501.70331649
14Basal transcription factors_Homo sapiens_hsa030221.70306518
15Circadian entrainment_Homo sapiens_hsa047131.66106921
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64998174
17RNA transport_Homo sapiens_hsa030131.63405560
18mRNA surveillance pathway_Homo sapiens_hsa030151.62329562
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60847978
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56091227
21N-Glycan biosynthesis_Homo sapiens_hsa005101.54629422
22Prolactin signaling pathway_Homo sapiens_hsa049171.53658925
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51166021
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50628154
25Glucagon signaling pathway_Homo sapiens_hsa049221.50041216
26Olfactory transduction_Homo sapiens_hsa047401.47823297
27Sulfur metabolism_Homo sapiens_hsa009201.46083271
28GABAergic synapse_Homo sapiens_hsa047271.46048594
29Renin secretion_Homo sapiens_hsa049241.44901085
30Dorso-ventral axis formation_Homo sapiens_hsa043201.43958499
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38554413
32Huntingtons disease_Homo sapiens_hsa050161.38459739
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36552126
34Fatty acid elongation_Homo sapiens_hsa000621.36456447
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33379440
36Dilated cardiomyopathy_Homo sapiens_hsa054141.29573992
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28712371
38Oxytocin signaling pathway_Homo sapiens_hsa049211.26669041
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25945959
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24172201
41Morphine addiction_Homo sapiens_hsa050321.22412790
42Glutamatergic synapse_Homo sapiens_hsa047241.22293620
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21471056
44Insulin secretion_Homo sapiens_hsa049111.18536439
45Serotonergic synapse_Homo sapiens_hsa047261.18080123
46Hippo signaling pathway_Homo sapiens_hsa043901.17917504
47Axon guidance_Homo sapiens_hsa043601.16215591
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.14889188
49Cell cycle_Homo sapiens_hsa041101.14830882
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14219532
51Vibrio cholerae infection_Homo sapiens_hsa051101.11988322
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09769422
53Tight junction_Homo sapiens_hsa045301.09485906
54SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08109380
55Measles_Homo sapiens_hsa051621.07709642
56Primary immunodeficiency_Homo sapiens_hsa053401.07379624
57Pyruvate metabolism_Homo sapiens_hsa006201.07315082
58B cell receptor signaling pathway_Homo sapiens_hsa046621.04789840
59Wnt signaling pathway_Homo sapiens_hsa043101.04531987
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04412984
61FoxO signaling pathway_Homo sapiens_hsa040681.02229749
62Long-term depression_Homo sapiens_hsa047301.02129215
63Alcoholism_Homo sapiens_hsa050341.01904378
64Intestinal immune network for IgA production_Homo sapiens_hsa046721.01709105
65p53 signaling pathway_Homo sapiens_hsa041151.01078230
66Taste transduction_Homo sapiens_hsa047421.00400051
67Cholinergic synapse_Homo sapiens_hsa047250.98321710
68Proteasome_Homo sapiens_hsa030500.96616349
69TGF-beta signaling pathway_Homo sapiens_hsa043500.96134054
70Calcium signaling pathway_Homo sapiens_hsa040200.94938265
71Fanconi anemia pathway_Homo sapiens_hsa034600.93866475
72Estrogen signaling pathway_Homo sapiens_hsa049150.93490724
73Adherens junction_Homo sapiens_hsa045200.92989163
74Melanogenesis_Homo sapiens_hsa049160.92593548
75Endometrial cancer_Homo sapiens_hsa052130.92429393
76T cell receptor signaling pathway_Homo sapiens_hsa046600.91847383
77Spliceosome_Homo sapiens_hsa030400.90791795
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.90432920
79Gap junction_Homo sapiens_hsa045400.90137058
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89556606
81Parkinsons disease_Homo sapiens_hsa050120.87639953
82Sphingolipid metabolism_Homo sapiens_hsa006000.87626120
83Glioma_Homo sapiens_hsa052140.87426401
84Insulin resistance_Homo sapiens_hsa049310.86589010
85Hedgehog signaling pathway_Homo sapiens_hsa043400.86481507
86Collecting duct acid secretion_Homo sapiens_hsa049660.86200646
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85999198
88Shigellosis_Homo sapiens_hsa051310.85823582
89Colorectal cancer_Homo sapiens_hsa052100.85635893
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85121309
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83632435
92RNA degradation_Homo sapiens_hsa030180.83609972
93ECM-receptor interaction_Homo sapiens_hsa045120.83594059
94Chronic myeloid leukemia_Homo sapiens_hsa052200.80037400
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79942855
96ErbB signaling pathway_Homo sapiens_hsa040120.79293391
97Legionellosis_Homo sapiens_hsa051340.79027217
98Oxidative phosphorylation_Homo sapiens_hsa001900.78871924
99Focal adhesion_Homo sapiens_hsa045100.76062996
100Basal cell carcinoma_Homo sapiens_hsa052170.75586450
101Circadian rhythm_Homo sapiens_hsa047100.75415571
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75289090
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73430241
104Cocaine addiction_Homo sapiens_hsa050300.73241729
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72566153
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72469215
107Renal cell carcinoma_Homo sapiens_hsa052110.71787957
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71783918
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.70773733
110Alzheimers disease_Homo sapiens_hsa050100.70591903
111Salivary secretion_Homo sapiens_hsa049700.69301108
112cAMP signaling pathway_Homo sapiens_hsa040240.68661901
113Hepatitis B_Homo sapiens_hsa051610.68345208
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67887753
115Type II diabetes mellitus_Homo sapiens_hsa049300.66560222
116Hepatitis C_Homo sapiens_hsa051600.66499033
117Protein export_Homo sapiens_hsa030600.66482339
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.66192830
119Gastric acid secretion_Homo sapiens_hsa049710.66159363
120Homologous recombination_Homo sapiens_hsa034400.63186864
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62388145
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.61284828
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60876956
124mTOR signaling pathway_Homo sapiens_hsa041500.60864764
125Pancreatic cancer_Homo sapiens_hsa052120.60837156
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60681146
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60132654
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60076165
129Platelet activation_Homo sapiens_hsa046110.59631792
130Insulin signaling pathway_Homo sapiens_hsa049100.59507709
131Influenza A_Homo sapiens_hsa051640.58319831
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57805878
133GnRH signaling pathway_Homo sapiens_hsa049120.57443622
134Thyroid cancer_Homo sapiens_hsa052160.56880116
135AMPK signaling pathway_Homo sapiens_hsa041520.56190633
136Proteoglycans in cancer_Homo sapiens_hsa052050.55392728
137Nucleotide excision repair_Homo sapiens_hsa034200.55373738
138TNF signaling pathway_Homo sapiens_hsa046680.54838340
139HIF-1 signaling pathway_Homo sapiens_hsa040660.54587917
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.54201988
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53726492
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53006314
143Prostate cancer_Homo sapiens_hsa052150.52246477
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52160905
145Melanoma_Homo sapiens_hsa052180.50933278
146ABC transporters_Homo sapiens_hsa020100.50665980
147Propanoate metabolism_Homo sapiens_hsa006400.50134056
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49806299
149Inositol phosphate metabolism_Homo sapiens_hsa005620.49247755
150Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47677923
151One carbon pool by folate_Homo sapiens_hsa006700.46192458
152Viral myocarditis_Homo sapiens_hsa054160.44717672
153Small cell lung cancer_Homo sapiens_hsa052220.41727874
154Herpes simplex infection_Homo sapiens_hsa051680.41283716
155Toxoplasmosis_Homo sapiens_hsa051450.39477105
156Epstein-Barr virus infection_Homo sapiens_hsa051690.38074811
157Viral carcinogenesis_Homo sapiens_hsa052030.38012364
158Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37122980
159Acute myeloid leukemia_Homo sapiens_hsa052210.36131138
160Fatty acid metabolism_Homo sapiens_hsa012120.35397005

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