FYTTD1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of protein activation cascade (GO:2000257)8.97181896
2regulation of complement activation (GO:0030449)8.61230000
3drug catabolic process (GO:0042737)8.33328938
4exogenous drug catabolic process (GO:0042738)8.08505132
5omega-hydroxylase P450 pathway (GO:0097267)7.56929099
6regulation of fibrinolysis (GO:0051917)7.53806573
7negative regulation of fibrinolysis (GO:0051918)7.20520712
8epoxygenase P450 pathway (GO:0019373)7.07023534
9blood coagulation, intrinsic pathway (GO:0007597)6.94405212
10cellular glucuronidation (GO:0052695)6.61227364
11urea metabolic process (GO:0019627)6.51920984
12glucuronate metabolic process (GO:0019585)6.22708915
13uronic acid metabolic process (GO:0006063)6.22708915
14negative regulation of cholesterol transport (GO:0032375)6.07765742
15negative regulation of sterol transport (GO:0032372)6.07765742
16nitrogen cycle metabolic process (GO:0071941)6.02617512
17peptidyl-glutamic acid carboxylation (GO:0017187)5.98361827
18protein carboxylation (GO:0018214)5.98361827
19oxidative demethylation (GO:0070989)5.92204995
20fibrinolysis (GO:0042730)5.85014029
21bile acid biosynthetic process (GO:0006699)5.75625978
22protein activation cascade (GO:0072376)5.60439507
23urea cycle (GO:0000050)5.58756081
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.58537192
25L-phenylalanine catabolic process (GO:0006559)5.53039559
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.53039559
27glyoxylate metabolic process (GO:0046487)5.35401795
28negative regulation of protein activation cascade (GO:2000258)5.35232188
29imidazole-containing compound metabolic process (GO:0052803)5.32682455
30bile acid metabolic process (GO:0008206)5.25362312
31regulation of humoral immune response (GO:0002920)5.23748168
32regulation of cholesterol esterification (GO:0010872)5.22602396
33complement activation (GO:0006956)5.16407291
34drug metabolic process (GO:0017144)5.12734301
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.01861902
36L-phenylalanine metabolic process (GO:0006558)5.01861902
37low-density lipoprotein particle remodeling (GO:0034374)4.97935797
38bile acid and bile salt transport (GO:0015721)4.97445354
39phospholipid efflux (GO:0033700)4.84148571
40arginine catabolic process (GO:0006527)4.82839146
41regulation of bile acid biosynthetic process (GO:0070857)4.80123795
42cholesterol efflux (GO:0033344)4.76312604
43complement activation, classical pathway (GO:0006958)4.74016928
44high-density lipoprotein particle remodeling (GO:0034375)4.73340749
45positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.71479526
46protein-lipid complex remodeling (GO:0034368)4.70329142
47macromolecular complex remodeling (GO:0034367)4.70329142
48plasma lipoprotein particle remodeling (GO:0034369)4.70329142
49aromatic amino acid family catabolic process (GO:0009074)4.63664399
50phosphate ion transmembrane transport (GO:0035435)4.61481478
51embryonic retina morphogenesis in camera-type eye (GO:0060059)4.51505587
52glycine metabolic process (GO:0006544)4.47741978
53phospholipid homeostasis (GO:0055091)4.42820187
54reverse cholesterol transport (GO:0043691)4.40451507
55negative regulation of hemostasis (GO:1900047)4.36468686
56negative regulation of blood coagulation (GO:0030195)4.36468686
57serine family amino acid catabolic process (GO:0009071)4.26564295
58negative regulation of complement activation (GO:0045916)4.26137326
59arginine metabolic process (GO:0006525)4.19587172
60cytolysis (GO:0019835)4.14485522
61intestinal cholesterol absorption (GO:0030299)4.13173775
62regulation of apoptotic cell clearance (GO:2000425)4.11883110
63opsonization (GO:0008228)4.10949619
64acute-phase response (GO:0006953)4.06371900
65S-adenosylmethionine metabolic process (GO:0046500)4.03976189
66phosphate ion transport (GO:0006817)3.97452015
67alkaloid metabolic process (GO:0009820)3.95342698
68negative regulation of coagulation (GO:0050819)3.93634090
69regulation of triglyceride catabolic process (GO:0010896)3.93199588
70negative regulation of wound healing (GO:0061045)3.91752156
71flavonoid metabolic process (GO:0009812)3.86747078
72plasma lipoprotein particle assembly (GO:0034377)3.85737159
73indole-containing compound catabolic process (GO:0042436)3.84219812
74indolalkylamine catabolic process (GO:0046218)3.84219812
75tryptophan catabolic process (GO:0006569)3.84219812
76triglyceride homeostasis (GO:0070328)3.83020611
77acylglycerol homeostasis (GO:0055090)3.83020611
78regulation of hexokinase activity (GO:1903299)3.81760837
79regulation of glucokinase activity (GO:0033131)3.81760837
80serine family amino acid metabolic process (GO:0009069)3.81702778
81glutamate metabolic process (GO:0006536)3.80360074
82plasma lipoprotein particle clearance (GO:0034381)3.78276126
83regulation of acute inflammatory response (GO:0002673)3.73182305
84response to vitamin A (GO:0033189)3.70924429
85regulation of plasminogen activation (GO:0010755)3.69510780
86negative regulation of lipase activity (GO:0060192)3.64552117
87killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.64431578
88disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.64431578
89plasma lipoprotein particle organization (GO:0071827)3.58469975
90very-low-density lipoprotein particle assembly (GO:0034379)3.55911353
91amino-acid betaine metabolic process (GO:0006577)3.52541799
92alpha-linolenic acid metabolic process (GO:0036109)3.51160558
93pyrimidine nucleobase catabolic process (GO:0006208)3.49035739
94positive regulation of hemostasis (GO:1900048)3.46839182
95positive regulation of blood coagulation (GO:0030194)3.46839182
96negative regulation of digestive system process (GO:0060457)3.40721614
97heme transport (GO:0015886)3.39120345
98alpha-amino acid catabolic process (GO:1901606)3.35431881
99protein-lipid complex assembly (GO:0065005)3.31610984
100complement activation, alternative pathway (GO:0006957)10.4973496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.35726522
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.94185452
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.17626736
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.66654663
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.32033211
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.15144305
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.78134043
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.23143168
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.13925782
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.75055595
11NFE2_27457419_Chip-Seq_LIVER_Mouse2.46980532
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39934580
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.33635826
14GATA1_22025678_ChIP-Seq_K562_Human2.31499184
15FOXA2_19822575_ChIP-Seq_HepG2_Human2.22620273
16TAF15_26573619_Chip-Seq_HEK293_Human2.20685341
17SUZ12_27294783_Chip-Seq_NPCs_Mouse2.17048540
18EZH2_27294783_Chip-Seq_NPCs_Mouse2.00230414
19TCF4_18268006_ChIP-ChIP_LS174T_Human1.97958132
20HNF4A_19822575_ChIP-Seq_HepG2_Human1.92202772
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.76264250
22GBX2_23144817_ChIP-Seq_PC3_Human1.75923404
23CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.68457000
24HNFA_21074721_ChIP-Seq_CACO-2_Human1.63642197
25CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.63516806
26NFYA_21822215_ChIP-Seq_K562_Human1.63505568
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61850606
28ER_23166858_ChIP-Seq_MCF-7_Human1.59853592
29PHF8_20622853_ChIP-Seq_HELA_Human1.58683595
30GATA6_21074721_ChIP-Seq_CACO-2_Human1.57345575
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55991302
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54959239
33CBX2_22325352_ChIP-Seq_293T-Rex_Human1.50719239
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46764722
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.46203963
36GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.45694516
37SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.44293309
38ETV1_20927104_ChIP-Seq_GIST48_Human1.42099244
39E2F1_18555785_Chip-Seq_ESCs_Mouse1.41849186
40OCT4_18555785_Chip-Seq_ESCs_Mouse1.41036293
41NFYB_21822215_ChIP-Seq_K562_Human1.39599185
42P53_22387025_ChIP-Seq_ESCs_Mouse1.37613329
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.36153360
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35710334
45OCT4_21477851_ChIP-Seq_ESCs_Mouse1.35664249
46P300_18555785_Chip-Seq_ESCs_Mouse1.35256565
47SMAD1_18555785_Chip-Seq_ESCs_Mouse1.34148184
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33620278
49PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.33485164
50IRF1_19129219_ChIP-ChIP_H3396_Human1.33405561
51CRX_20693478_ChIP-Seq_RETINA_Mouse1.32749418
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32551780
53RBPJ_21746931_ChIP-Seq_IB4_Human1.31434710
54KLF4_18555785_Chip-Seq_ESCs_Mouse1.30912095
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.29178590
56ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28789862
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.28233017
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27947277
59PU1_27457419_Chip-Seq_LIVER_Mouse1.26611500
60SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25910696
61TBL1_22424771_ChIP-Seq_293T_Human1.25196904
62SOX2_18555785_Chip-Seq_ESCs_Mouse1.23458578
63NMYC_18555785_Chip-Seq_ESCs_Mouse1.22657183
64IGF1R_20145208_ChIP-Seq_DFB_Human1.21766512
65RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21441466
66CTCF_18555785_Chip-Seq_ESCs_Mouse1.21262320
67ZFX_18555785_Chip-Seq_ESCs_Mouse1.20555161
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17794024
69HTT_18923047_ChIP-ChIP_STHdh_Human1.16939980
70TP53_18474530_ChIP-ChIP_U2OS_Human1.16265428
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15415382
72TP53_16413492_ChIP-PET_HCT116_Human1.13764614
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12662682
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09668814
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09208559
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07871668
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06541955
78CBP_20019798_ChIP-Seq_JUKART_Human1.06541955
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04384826
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04222704
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03155542
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97855590
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97284458
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96879130
85GATA4_25053715_ChIP-Seq_YYC3_Human0.95568655
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95253373
87PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91960611
88FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91163132
89KAP1_22055183_ChIP-Seq_ESCs_Mouse0.91052918
90NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90291024
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90291024
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89486250
93VDR_22108803_ChIP-Seq_LS180_Human0.87007572
94GATA6_25053715_ChIP-Seq_YYC3_Human0.86268574
95SALL1_21062744_ChIP-ChIP_HESCs_Human0.83846404
96FOXA1_25552417_ChIP-Seq_VCAP_Human0.83824785
97BCAT_22108803_ChIP-Seq_LS180_Human0.81768130
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80803649
99STAT3_23295773_ChIP-Seq_U87_Human0.80114294
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78762179

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.85437725
2MP0002138_abnormal_hepatobiliary_system7.98003708
3MP0005085_abnormal_gallbladder_physiolo6.22439332
4MP0003195_calcinosis5.76625660
5MP0005365_abnormal_bile_salt5.31668702
6MP0003252_abnormal_bile_duct4.98199150
7MP0008875_abnormal_xenobiotic_pharmacok3.88958987
8MP0005360_urolithiasis3.68321780
9MP0010368_abnormal_lymphatic_system3.59114571
10MP0001666_abnormal_nutrient_absorption3.05347741
11MP0010329_abnormal_lipoprotein_level2.89938817
12MP0003868_abnormal_feces_composition2.73909930
13MP0002876_abnormal_thyroid_physiology2.09541862
14MP0001661_extended_life_span2.04436428
15MP0005332_abnormal_amino_acid1.84881155
16MP0000609_abnormal_liver_physiology1.68848832
17MP0003890_abnormal_embryonic-extraembry1.66113422
18MP0002118_abnormal_lipid_homeostasis1.65091896
19MP0002254_reproductive_system_inflammat1.64416710
20MP0003191_abnormal_cellular_cholesterol1.52100274
21MP0009697_abnormal_copulation1.40710650
22MP0005408_hypopigmentation1.38320623
23MP0001764_abnormal_homeostasis1.32398555
24MP0000604_amyloidosis1.27994230
25MP0000566_synostosis1.18949911
26MP0001915_intracranial_hemorrhage1.12609198
27MP0005187_abnormal_penis_morphology1.06834433
28MP0003690_abnormal_glial_cell1.06813933
29MP0002928_abnormal_bile_duct1.05561146
30MP0000598_abnormal_liver_morphology1.02252168
31MP0008057_abnormal_DNA_replication1.01407020
32MP0005319_abnormal_enzyme/_coenzyme0.99497714
33MP0005670_abnormal_white_adipose0.97344821
34MP0005376_homeostasis/metabolism_phenot0.93001649
35MP0002971_abnormal_brown_adipose0.91268341
36MP0004019_abnormal_vitamin_homeostasis0.90243404
37MP0009840_abnormal_foam_cell0.88889448
38MP0004133_heterotaxia0.88523513
39MP0005647_abnormal_sex_gland0.86037700
40MP0003943_abnormal_hepatobiliary_system0.85142547
41MP0003011_delayed_dark_adaptation0.80440281
42MP0005220_abnormal_exocrine_pancreas0.78210980
43MP0009642_abnormal_blood_homeostasis0.77451978
44MP0005164_abnormal_response_to0.77123590
45MP0002168_other_aberrant_phenotype0.76836860
46MP0003656_abnormal_erythrocyte_physiolo0.74458679
47MP0001879_abnormal_lymphatic_vessel0.73837247
48MP0008469_abnormal_protein_level0.73057888
49MP0005584_abnormal_enzyme/coenzyme_acti0.71261592
50MP0002078_abnormal_glucose_homeostasis0.69724650
51MP0005266_abnormal_metabolism0.67820015
52MP0005395_other_phenotype0.67727889
53MP0004883_abnormal_blood_vessel0.65815302
54MP0003950_abnormal_plasma_membrane0.63320251
55MP0005451_abnormal_body_composition0.63027662
56MP0005636_abnormal_mineral_homeostasis0.62938369
57MP0009643_abnormal_urine_homeostasis0.59563938
58MP0001346_abnormal_lacrimal_gland0.56812154
59MP0005334_abnormal_fat_pad0.55877137
60MP0009115_abnormal_fat_cell0.55848777
61MP0001944_abnormal_pancreas_morphology0.55708299
62MP0005535_abnormal_body_temperature0.55597788
63MP0003632_abnormal_nervous_system0.55194967
64MP0004272_abnormal_basement_membrane0.52649646
65MP0003959_abnormal_lean_body0.52473618
66MP0003646_muscle_fatigue0.50708117
67MP0001919_abnormal_reproductive_system0.50698392
68MP0002132_abnormal_respiratory_system0.48102116
69MP0001324_abnormal_eye_pigmentation0.47342115
70MP0009763_increased_sensitivity_to0.47213457
71MP0003953_abnormal_hormone_level0.45611917
72MP0003638_abnormal_response/metabolism_0.45252259
73MP0000920_abnormal_myelination0.44022031
74MP0004130_abnormal_muscle_cell0.43834049
75MP0005464_abnormal_platelet_physiology0.41842307
76MP0004233_abnormal_muscle_weight0.40688459
77MP0005084_abnormal_gallbladder_morpholo0.40271774
78MP0004147_increased_porphyrin_level0.38248523
79MP0002089_abnormal_postnatal_growth/wei0.38018737
80MP0005379_endocrine/exocrine_gland_phen0.37646137
81MP0002938_white_spotting0.36092177
82MP0000569_abnormal_digit_pigmentation0.35682417
83MP0003186_abnormal_redox_activity0.34489054
84MP0003633_abnormal_nervous_system0.34058732
85MP0003183_abnormal_peptide_metabolism0.31074964
86MP0003122_maternal_imprinting0.30585968
87MP0003699_abnormal_female_reproductive0.30523641
88MP0002697_abnormal_eye_size0.28995849
89MP0002128_abnormal_blood_circulation0.28504566
90MP0000249_abnormal_blood_vessel0.27034833
91MP0005023_abnormal_wound_healing0.26945680
92MP0003631_nervous_system_phenotype0.26781618
93MP0003123_paternal_imprinting0.25731370
94MP0000639_abnormal_adrenal_gland0.25109939
95MP0008961_abnormal_basal_metabolism0.24360338
96MP0005551_abnormal_eye_electrophysiolog0.23838700
97MP0004924_abnormal_behavior0.23823046
98MP0005386_behavior/neurological_phenoty0.23823046
99MP0005197_abnormal_uvea_morphology0.23591983
100MP0006276_abnormal_autonomic_nervous0.23041040

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.78846244
2Abnormality of complement system (HP:0005339)7.76674033
3Conjugated hyperbilirubinemia (HP:0002908)6.99773930
4Hypobetalipoproteinemia (HP:0003563)6.66592378
5Glomerulonephritis (HP:0000099)6.58981072
6Intrahepatic cholestasis (HP:0001406)6.13042591
7Abnormality of the common coagulation pathway (HP:0010990)5.78299824
8Joint hemorrhage (HP:0005261)5.76954776
9Abnormality of pyrimidine metabolism (HP:0004353)5.72476008
10Osteomalacia (HP:0002749)5.37351207
11Systemic lupus erythematosus (HP:0002725)4.94931270
12Abnormality of aromatic amino acid family metabolism (HP:0004338)4.64842167
13Fat malabsorption (HP:0002630)4.52107785
14Generalized aminoaciduria (HP:0002909)4.51954957
15Spontaneous abortion (HP:0005268)4.45164140
16Xanthomatosis (HP:0000991)4.25433399
17Nephritis (HP:0000123)4.02924919
18Abnormality of the intrinsic pathway (HP:0010989)3.98488262
19Hypolipoproteinemia (HP:0010981)3.73137067
20Hypercholesterolemia (HP:0003124)3.39413305
21Steatorrhea (HP:0002570)3.38660620
22Abnormality of nucleobase metabolism (HP:0010932)3.37779152
23Rickets (HP:0002748)3.34072969
24Recurrent gram-negative bacterial infections (HP:0005420)3.15049781
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.04146406
26Abnormal biliary tract physiology (HP:0012439)3.03671298
27Bile duct proliferation (HP:0001408)3.03671298
28Arthropathy (HP:0003040)2.99846344
29Menorrhagia (HP:0000132)2.83158680
30Hepatocellular carcinoma (HP:0001402)2.77628697
31Gingival bleeding (HP:0000225)2.73002710
32Acanthocytosis (HP:0001927)2.61239997
33Vascular calcification (HP:0004934)2.59980025
34Hyperlipoproteinemia (HP:0010980)2.56315498
35Hyperammonemia (HP:0001987)2.47777675
36Abnormality of vitamin metabolism (HP:0100508)2.47169840
37Epidermoid cyst (HP:0200040)2.44953630
38Hyperphosphaturia (HP:0003109)2.44523442
39Delayed CNS myelination (HP:0002188)2.42508231
40Hypophosphatemic rickets (HP:0004912)2.41132918
41Elevated alkaline phosphatase (HP:0003155)2.39879485
42Decreased subcutaneous fat (HP:0001002)2.39374090
43Cholelithiasis (HP:0001081)2.34079355
44Abnormality of purine metabolism (HP:0004352)2.30209760
45Increased serum ferritin (HP:0003281)2.28812883
46Cardiovascular calcification (HP:0011915)2.26123510
47Hyperbilirubinemia (HP:0002904)2.20949117
48Scanning speech (HP:0002168)2.20756064
49Abnormal gallbladder morphology (HP:0012437)2.18592902
50Abnormality of alkaline phosphatase activity (HP:0004379)2.16721982
51Abnormal enzyme/coenzyme activity (HP:0012379)2.13448835
52Hypoalphalipoproteinemia (HP:0003233)2.11688918
53Abnormality of urine glucose concentration (HP:0011016)2.11278124
54Glycosuria (HP:0003076)2.11278124
55Abnormality of methionine metabolism (HP:0010901)2.09116270
56Poikilocytosis (HP:0004447)2.06864659
57Cholecystitis (HP:0001082)2.03448090
58Abnormal gallbladder physiology (HP:0012438)2.03448090
59Mitral stenosis (HP:0001718)2.00559079
60Deep venous thrombosis (HP:0002625)11.4276460
61Complement deficiency (HP:0004431)10.1687220
62Prolonged partial thromboplastin time (HP:0003645)10.0462952
63Abnormality of iron homeostasis (HP:0011031)1.98305320
64Sensorimotor neuropathy (HP:0007141)1.98259622
65Abnormal tarsal ossification (HP:0008369)1.96951522
66Fair hair (HP:0002286)1.96731561
67Thrombophlebitis (HP:0004418)1.93329595
68Myocardial infarction (HP:0001658)1.93078458
69Abnormal urine phosphate concentration (HP:0012599)1.92680629
70Peritonitis (HP:0002586)1.90231590
71Decreased muscle mass (HP:0003199)1.89912097
72Enlarged kidneys (HP:0000105)1.89157658
73Wrist flexion contracture (HP:0001239)1.87668938
74Purpura (HP:0000979)1.86298237
75Abnormality of transition element cation homeostasis (HP:0011030)1.85203275
76Bifid scrotum (HP:0000048)1.83494106
77Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81768494
78Hypophosphatemia (HP:0002148)1.78818164
79Toxemia of pregnancy (HP:0100603)1.78012114
80Hyperglycinemia (HP:0002154)1.74674727
81Hemorrhage of the eye (HP:0011885)1.72927838
82Gastrointestinal infarctions (HP:0005244)1.72475720
83Abnormality of subcutaneous fat tissue (HP:0001001)1.70820494
84Anorexia (HP:0002039)1.63465174
85Abnormality of aspartate family amino acid metabolism (HP:0010899)1.61725406
86Joint swelling (HP:0001386)1.58142265
87Acute hepatic failure (HP:0006554)1.57418242
88Neoplasm of the liver (HP:0002896)1.57296431
89Epistaxis (HP:0000421)1.56972317
90Seborrheic dermatitis (HP:0001051)1.56196699
91Reduced antithrombin III activity (HP:0001976)1.55933651
92Gout (HP:0001997)1.54325567
93Hyperglycinuria (HP:0003108)1.53623511
94Abnormality of serum amino acid levels (HP:0003112)1.52936966
95Proximal tubulopathy (HP:0000114)1.52928468
96Abnormality of serine family amino acid metabolism (HP:0010894)1.52840802
97Abnormality of glycine metabolism (HP:0010895)1.52840802
98Abnormal foot bone ossification (HP:0010675)1.50808727
99Skin nodule (HP:0200036)1.45598779
100Increased mean platelet volume (HP:0011877)1.41721343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.59091915
2FRK4.94800427
3PIK3CA3.34442828
4TAF12.87039258
5BRSK22.76673165
6WNK32.69196865
7PIK3CG2.57162108
8TAOK32.47844397
9AKT32.25342791
10GRK11.96074288
11CAMK1G1.92652514
12CAMKK21.85784415
13NEK91.85624563
14PNCK1.81260926
15PRKAA21.74851625
16NLK1.73320190
17FGFR41.71698523
18CAMK1D1.65264594
19STK381.60375805
20RIPK11.58171956
21FGFR21.50418868
22FGFR31.50389047
23CDK191.45164500
24MAP3K21.44559028
25WNK11.42020048
26CDK31.40793315
27PINK11.38226671
28PRKACG1.37947492
29WNK41.30792847
30BCR1.22444410
31JAK21.20975113
32PRKAA11.15592435
33PAK31.14584595
34NTRK31.13652663
35CHUK1.12327048
36PRKCG1.10831804
37ERBB41.06875027
38CSNK1E1.05415962
39EPHA31.03632715
40MAPK111.02955460
41YES10.98924427
42IGF1R0.85965004
43MUSK0.84375778
44KSR20.84316357
45EIF2AK10.80844680
46MAP3K40.78813642
47NEK10.78293199
48INSRR0.77125429
49MAP4K20.75502400
50DYRK1B0.74207252
51SGK2230.72542015
52SGK4940.72542015
53SCYL20.71578153
54TYK20.71276584
55CDK120.68272653
56ICK0.67885475
57BMPR1B0.67731678
58PRKG10.66963343
59JAK10.65282832
60CSNK1D0.62316800
61BRSK10.62214190
62FGFR10.60474705
63RPS6KB10.60305685
64LATS10.60081482
65MAP2K70.60017130
66PRKCB0.59962436
67PRKACB0.58047968
68KSR10.57295085
69PRKACA0.56376679
70FER0.56238785
71SGK20.55343268
72MTOR0.52099461
73STK110.52058015
74CAMK40.51563502
75PBK0.51123471
76ERBB20.50584499
77RPS6KA30.49688223
78SGK10.48410151
79PRKCZ0.48222408
80MAP2K10.48111286
81IRAK30.46217212
82CDK60.45586634
83MKNK20.44997383
84CSNK2A10.44271297
85CSF1R0.43680328
86CSNK2A20.42736921
87MST40.41762693
88FLT30.41648151
89ERN10.40118972
90RET0.40004783
91PRKCE0.39754049
92BRD40.39244581
93MAPK140.38378721
94CASK0.37732134
95PDPK10.37605473
96ADRBK20.34584297
97MAP2K40.33354751
98MAPK10.33079179
99OBSCN0.32722205
100PDK10.32282658

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.78454772
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.32247617
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.91577836
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.87021510
5Retinol metabolism_Homo sapiens_hsa008303.32331715
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.27323386
7Pentose and glucuronate interconversions_Homo sapiens_hsa000403.17927114
8Steroid hormone biosynthesis_Homo sapiens_hsa001402.96441324
9Chemical carcinogenesis_Homo sapiens_hsa052042.90279944
10Arginine biosynthesis_Homo sapiens_hsa002202.80398030
11Drug metabolism - other enzymes_Homo sapiens_hsa009832.60848675
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.49891210
13Caffeine metabolism_Homo sapiens_hsa002322.28127443
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.18804862
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10995691
16Histidine metabolism_Homo sapiens_hsa003402.00441039
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92798189
18Starch and sucrose metabolism_Homo sapiens_hsa005001.92079599
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.91847680
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.91244146
21Linoleic acid metabolism_Homo sapiens_hsa005911.89151547
22Bile secretion_Homo sapiens_hsa049761.86427530
23Staphylococcus aureus infection_Homo sapiens_hsa051501.85486304
24Butanoate metabolism_Homo sapiens_hsa006501.81222239
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77783555
26Phenylalanine metabolism_Homo sapiens_hsa003601.75938676
27Fatty acid degradation_Homo sapiens_hsa000711.72335324
28Tryptophan metabolism_Homo sapiens_hsa003801.62884327
29ABC transporters_Homo sapiens_hsa020101.41975661
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35207987
31Tyrosine metabolism_Homo sapiens_hsa003501.30522620
32PPAR signaling pathway_Homo sapiens_hsa033201.29769191
33Fat digestion and absorption_Homo sapiens_hsa049751.26762398
34beta-Alanine metabolism_Homo sapiens_hsa004101.19433100
35Peroxisome_Homo sapiens_hsa041461.19288629
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18733206
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18697262
38Prion diseases_Homo sapiens_hsa050201.15513075
39Vitamin B6 metabolism_Homo sapiens_hsa007501.12431530
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.01127820
41Fatty acid metabolism_Homo sapiens_hsa012120.96785954
42Arachidonic acid metabolism_Homo sapiens_hsa005900.93962714
43Biosynthesis of amino acids_Homo sapiens_hsa012300.93955429
44Arginine and proline metabolism_Homo sapiens_hsa003300.90631185
45Fatty acid biosynthesis_Homo sapiens_hsa000610.83906089
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.83372772
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82763996
48Selenocompound metabolism_Homo sapiens_hsa004500.81003217
49Propanoate metabolism_Homo sapiens_hsa006400.78978741
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75242462
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72056070
52Pyruvate metabolism_Homo sapiens_hsa006200.67108165
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54416922
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53562226
55Insulin resistance_Homo sapiens_hsa049310.51742179
56Carbon metabolism_Homo sapiens_hsa012000.50542578
57Pertussis_Homo sapiens_hsa051330.45681396
58Glucagon signaling pathway_Homo sapiens_hsa049220.44482630
59Glycerolipid metabolism_Homo sapiens_hsa005610.42511023
60Metabolic pathways_Homo sapiens_hsa011000.38568096
61Nitrogen metabolism_Homo sapiens_hsa009100.38450032
62Circadian rhythm_Homo sapiens_hsa047100.37803622
63Lysine degradation_Homo sapiens_hsa003100.37298106
64TGF-beta signaling pathway_Homo sapiens_hsa043500.34998860
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.34566214
66Vitamin digestion and absorption_Homo sapiens_hsa049770.33767027
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32327923
68One carbon pool by folate_Homo sapiens_hsa006700.31915685
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31771091
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30878958
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27770003
72Systemic lupus erythematosus_Homo sapiens_hsa053220.24091854
73Fatty acid elongation_Homo sapiens_hsa000620.23639627
74Sulfur relay system_Homo sapiens_hsa041220.23018051
75N-Glycan biosynthesis_Homo sapiens_hsa005100.20021388
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18168029
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16727266
78Fructose and mannose metabolism_Homo sapiens_hsa000510.16665122
79Sulfur metabolism_Homo sapiens_hsa009200.15408628
80Type II diabetes mellitus_Homo sapiens_hsa049300.15105541
81Dorso-ventral axis formation_Homo sapiens_hsa043200.13059412
82AMPK signaling pathway_Homo sapiens_hsa041520.10149121
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09960621
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08636693
85Galactose metabolism_Homo sapiens_hsa000520.08095234
86Serotonergic synapse_Homo sapiens_hsa047260.03257903
87Circadian entrainment_Homo sapiens_hsa047130.02016276
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1617058
89Pentose phosphate pathway_Homo sapiens_hsa00030-0.1395454
90Ether lipid metabolism_Homo sapiens_hsa00565-0.1298456
91Glutathione metabolism_Homo sapiens_hsa00480-0.1266270
92Sphingolipid metabolism_Homo sapiens_hsa00600-0.1078232
93Mineral absorption_Homo sapiens_hsa04978-0.0811086
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0760852
95Steroid biosynthesis_Homo sapiens_hsa00100-0.0688589
96Insulin signaling pathway_Homo sapiens_hsa04910-0.0677958
97Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0603930
98Renin-angiotensin system_Homo sapiens_hsa04614-0.0530993
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0454244
100Amoebiasis_Homo sapiens_hsa05146-0.0421698

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