FZD10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)5.67076278
2regulation of posttranscriptional gene silencing (GO:0060147)5.67076278
3regulation of gene silencing by miRNA (GO:0060964)5.67076278
4viral transcription (GO:0019083)4.93990514
5epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.86781772
6pre-miRNA processing (GO:0031054)4.80181326
7paraxial mesoderm development (GO:0048339)4.78779225
8translational termination (GO:0006415)4.77388412
9sequestering of actin monomers (GO:0042989)4.72091353
10establishment of apical/basal cell polarity (GO:0035089)4.70194554
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38672336
12lateral sprouting from an epithelium (GO:0060601)4.21539372
13planar cell polarity pathway involved in neural tube closure (GO:0090179)4.21026609
14cornea development in camera-type eye (GO:0061303)4.12200335
15establishment or maintenance of monopolar cell polarity (GO:0061339)4.01785973
16establishment of monopolar cell polarity (GO:0061162)4.01785973
17cotranslational protein targeting to membrane (GO:0006613)3.98139845
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.97448862
19midbrain development (GO:0030901)3.95581969
20presynaptic membrane assembly (GO:0097105)3.94126688
21regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.89847982
22protein targeting to ER (GO:0045047)3.88641945
23anterior/posterior axis specification, embryo (GO:0008595)3.83962533
24limb bud formation (GO:0060174)3.83215206
25translational elongation (GO:0006414)3.76879888
26embryonic process involved in female pregnancy (GO:0060136)3.72784354
27polarized epithelial cell differentiation (GO:0030859)3.72732201
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.72390700
29retinal ganglion cell axon guidance (GO:0031290)3.71662875
30regulation of hippo signaling (GO:0035330)3.70783203
31notochord development (GO:0030903)3.67252338
32ATP synthesis coupled proton transport (GO:0015986)3.66418076
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.66418076
34neuron fate determination (GO:0048664)3.65300501
35regulation of sister chromatid cohesion (GO:0007063)3.63726061
36presynaptic membrane organization (GO:0097090)3.62166840
37endocardial cushion morphogenesis (GO:0003203)3.61912922
38negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.57114987
39neuronal stem cell maintenance (GO:0097150)3.56251196
40viral life cycle (GO:0019058)3.55165469
41cellular protein complex disassembly (GO:0043624)3.53691294
42negative regulation of axon guidance (GO:1902668)3.53455136
43protein localization to endoplasmic reticulum (GO:0070972)3.53346150
44molting cycle (GO:0042303)3.53341356
45hair cycle (GO:0042633)3.53341356
46negative regulation of axon extension involved in axon guidance (GO:0048843)3.53055493
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.52742861
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.52742861
49Notch signaling involved in heart development (GO:0061314)3.51534942
50nodal signaling pathway (GO:0038092)3.51436004
51thalamus development (GO:0021794)3.47083959
52positive regulation of catenin import into nucleus (GO:0035413)3.46405317
53heterochromatin organization (GO:0070828)3.46180540
54mitotic sister chromatid segregation (GO:0000070)3.45645255
55DNA unwinding involved in DNA replication (GO:0006268)3.45325173
56spinal cord development (GO:0021510)3.44776979
57protein localization to kinetochore (GO:0034501)3.44626737
58convergent extension (GO:0060026)3.42852789
59glomerulus development (GO:0032835)3.42540387
60postsynaptic membrane organization (GO:0001941)3.41587578
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.40969322
62head development (GO:0060322)3.36438232
63nuclear pore organization (GO:0006999)3.35576791
64somite development (GO:0061053)3.35198699
65formation of translation preinitiation complex (GO:0001731)3.33133247
66trophectodermal cell differentiation (GO:0001829)3.32696304
67proximal/distal pattern formation (GO:0009954)3.31971856
68mesenchyme morphogenesis (GO:0072132)3.31752634
69proline biosynthetic process (GO:0006561)3.29771696
70DNA replication-dependent nucleosome organization (GO:0034723)3.27938139
71DNA replication-dependent nucleosome assembly (GO:0006335)3.27938139
72positive regulation of gastrulation (GO:2000543)3.27382959
73kidney mesenchyme development (GO:0072074)3.26694487
74ribosomal small subunit assembly (GO:0000028)3.25940154
75negative regulation of mRNA processing (GO:0050686)3.25617086
76nuclear pore complex assembly (GO:0051292)3.24135343
77transcription from mitochondrial promoter (GO:0006390)3.22345059
78sister chromatid segregation (GO:0000819)3.21437360
79pattern specification involved in kidney development (GO:0061004)3.20197268
80axonal fasciculation (GO:0007413)3.20135063
81embryonic camera-type eye development (GO:0031076)3.19312160
82histone H4-K12 acetylation (GO:0043983)3.19074980
83spliceosomal tri-snRNP complex assembly (GO:0000244)3.18215373
84histone arginine methylation (GO:0034969)3.18175312
85regulation of non-canonical Wnt signaling pathway (GO:2000050)3.16785076
86lymph vessel development (GO:0001945)3.16765053
87radial glial cell differentiation (GO:0060019)3.16533989
88protein complex disassembly (GO:0043241)3.14293567
89positive regulation of embryonic development (GO:0040019)3.13745932
90mesenchymal cell development (GO:0014031)3.12499723
91eyelid development in camera-type eye (GO:0061029)3.12278580
92negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.08521914
93translational initiation (GO:0006413)3.08094532
94establishment of planar polarity (GO:0001736)3.04912773
95establishment of tissue polarity (GO:0007164)3.04912773
96replication fork processing (GO:0031297)3.04679280
97cochlea morphogenesis (GO:0090103)3.04237969
98negative regulation of epidermis development (GO:0045683)3.04149697
99cardiac epithelial to mesenchymal transition (GO:0060317)3.02263998
100face development (GO:0060324)3.01742506
101negative regulation of RNA splicing (GO:0033119)3.01373752
102epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00392614
103hematopoietic stem cell proliferation (GO:0071425)2.98919743
104establishment of protein localization to mitochondrial membrane (GO:0090151)2.98684676
105negative regulation of hormone biosynthetic process (GO:0032353)2.98560787
106macromolecular complex disassembly (GO:0032984)2.97291179
107dosage compensation (GO:0007549)2.96470359
108regulation of translational fidelity (GO:0006450)2.96086317
109DNA duplex unwinding (GO:0032508)2.96021624
110hindlimb morphogenesis (GO:0035137)2.95167751
111limb development (GO:0060173)2.94952818
112appendage development (GO:0048736)2.94952818
113Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.94944716
114DNA geometric change (GO:0032392)2.94798663
115regulation of gene silencing (GO:0060968)2.93577717
116anatomical structure regression (GO:0060033)2.93197436
117peptidyl-arginine omega-N-methylation (GO:0035247)2.92206434
118positive regulation of SMAD protein import into nucleus (GO:0060391)2.91524651
119mitotic nuclear envelope disassembly (GO:0007077)2.90999290
120somite rostral/caudal axis specification (GO:0032525)2.90252885
121lens fiber cell development (GO:0070307)2.90203795
122dendritic spine morphogenesis (GO:0060997)2.89269813
123primitive streak formation (GO:0090009)2.87952511
124behavioral response to nicotine (GO:0035095)2.86799810
125outer ear morphogenesis (GO:0042473)2.86340650
126digestive tract morphogenesis (GO:0048546)2.85552712
127regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.84075506
128maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83543565
129embryonic hindlimb morphogenesis (GO:0035116)2.82212374
130desmosome organization (GO:0002934)2.81922367
131keratinization (GO:0031424)2.81801556
132neural crest cell development (GO:0014032)2.81752709
133regulation of establishment of planar polarity (GO:0090175)2.81448243
134cranial suture morphogenesis (GO:0060363)2.81412210
135cell migration involved in gastrulation (GO:0042074)2.80677971
136stem cell development (GO:0048864)2.80650173
137chromatin assembly (GO:0031497)2.80432014
138anterior/posterior axis specification (GO:0009948)2.80366168
139regulation of double-strand break repair (GO:2000779)2.80359116
140metanephric mesenchyme development (GO:0072075)2.79695960
141regulation of stem cell maintenance (GO:2000036)2.78419641
142apoptotic process involved in morphogenesis (GO:0060561)2.78244813
143bone morphogenesis (GO:0060349)2.77553871
144cell surface receptor signaling pathway involved in heart development (GO:0061311)2.75669508
145otic vesicle formation (GO:0030916)2.75610691
146regulation of RNA export from nucleus (GO:0046831)2.74543744
147regulation of axon guidance (GO:1902667)2.74410304
148DNA strand renaturation (GO:0000733)2.73707383
149negative regulation of oligodendrocyte differentiation (GO:0048715)2.72593590
150camera-type eye morphogenesis (GO:0048593)2.71864673
151regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.71353809
152post-anal tail morphogenesis (GO:0036342)2.70452656
153nuclear envelope disassembly (GO:0051081)2.70350517
154membrane disassembly (GO:0030397)2.70350517
155mitotic G1 DNA damage checkpoint (GO:0031571)2.70145413
156regulation of hair follicle development (GO:0051797)2.69812310
157neural tube closure (GO:0001843)2.69496582
158intracellular estrogen receptor signaling pathway (GO:0030520)2.68983371
159lung-associated mesenchyme development (GO:0060484)2.68788565
160RNA stabilization (GO:0043489)2.68572381
161mRNA stabilization (GO:0048255)2.68572381
162negative regulation of mRNA metabolic process (GO:1903312)2.66863244
163bone trabecula formation (GO:0060346)2.66077843
164regulation of DNA damage checkpoint (GO:2000001)2.66027502
165tube closure (GO:0060606)2.65707829
166spinal cord association neuron differentiation (GO:0021527)2.63993884
167regulation of axon extension involved in axon guidance (GO:0048841)2.63631208
168spermatid nucleus differentiation (GO:0007289)2.63610005
169* non-canonical Wnt signaling pathway (GO:0035567)2.63438208
170protein targeting to membrane (GO:0006612)2.63362095
171regulation of nuclear cell cycle DNA replication (GO:0033262)2.63167533
172nonmotile primary cilium assembly (GO:0035058)2.62806138
173protein localization to chromosome, centromeric region (GO:0071459)2.61417916
174positive regulation of chromosome segregation (GO:0051984)2.60799493
175regulation of helicase activity (GO:0051095)2.60540817
176pituitary gland development (GO:0021983)2.58552472
177DNA strand elongation involved in DNA replication (GO:0006271)2.58277188
178neuron recognition (GO:0008038)2.52295796
179neuron fate specification (GO:0048665)2.52123563
180ventricular septum morphogenesis (GO:0060412)2.51956027
181cell migration involved in heart development (GO:0060973)2.50039253
182G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.49829631
183urogenital system development (GO:0001655)2.49692157
184cell-cell signaling involved in cell fate commitment (GO:0045168)2.48814855
185cochlea development (GO:0090102)2.48561699
186negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48179087
187ribosomal small subunit biogenesis (GO:0042274)2.47332951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.01031962
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.78964459
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.19209942
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.19209942
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.19209942
6EZH2_22144423_ChIP-Seq_EOC_Human4.16954579
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.55143308
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.47126943
9CBX2_27304074_Chip-Seq_ESCs_Mouse3.32086277
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.30328784
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.23227400
12EZH2_27304074_Chip-Seq_ESCs_Mouse3.15633800
13MYC_18555785_ChIP-Seq_MESCs_Mouse3.10202927
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.93342977
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.84895671
16* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.73750580
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.73024484
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62874843
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.61682732
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.61576069
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61486517
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.55718023
23SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.50650655
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49220907
25TP63_19390658_ChIP-ChIP_HaCaT_Human2.48621740
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.47024423
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46551022
28* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.43101467
29* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36389019
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35938788
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.34938461
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.31715881
33BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31405981
34* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30849116
35* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30849116
36RNF2_27304074_Chip-Seq_ESCs_Mouse2.27657400
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26595226
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24419843
39RNF2_27304074_Chip-Seq_NSC_Mouse2.23163750
40JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19632508
41* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.09583945
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06572962
43NANOG_18555785_ChIP-Seq_MESCs_Mouse2.06088001
44SOX2_18555785_ChIP-Seq_MESCs_Mouse2.05319846
45MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00434367
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.99783685
47* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98778754
48* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.96392530
49* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.96107988
50* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.94910286
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93522832
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92819765
53FUS_26573619_Chip-Seq_HEK293_Human1.87915458
54* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87772801
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87285555
56* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.85212770
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84146197
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83306335
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79647847
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.77990104
61EWS_26573619_Chip-Seq_HEK293_Human1.77046751
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73869201
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.73257607
64* VDR_22108803_ChIP-Seq_LS180_Human1.70654384
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69747849
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69124365
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68869167
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.68065457
69* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.67782973
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66538495
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66369182
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65989924
73MYC_22102868_ChIP-Seq_BL_Human1.63546621
74TAF15_26573619_Chip-Seq_HEK293_Human1.62715644
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60939448
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58949809
77* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55609403
78* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.54259881
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.54206074
80* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.52678978
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52592805
82SOX2_18692474_ChIP-Seq_MEFs_Mouse1.48465346
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.47148149
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.46894025
85IGF1R_20145208_ChIP-Seq_DFB_Human1.45909193
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44913898
87* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.43280502
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.41859423
89NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40343179
90* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.39614374
91NANOG_18692474_ChIP-Seq_MEFs_Mouse1.39337417
92XRN2_22483619_ChIP-Seq_HELA_Human1.38422180
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.37842347
94* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37047927
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36556885
96EGR1_19374776_ChIP-ChIP_THP-1_Human1.35856381
97* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35706471
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.33819384
99GBX2_23144817_ChIP-Seq_PC3_Human1.33318463
100* SMAD3_21741376_ChIP-Seq_EPCs_Human1.30612236
101* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.30472562
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28345404
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28288869
104P300_19829295_ChIP-Seq_ESCs_Human1.27399306
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.27208991
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27125827
107* TP53_20018659_ChIP-ChIP_R1E_Mouse1.25877318
108* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25290430
109* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23377237
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22733075
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22558781
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21987196
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21135076
114* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20098532
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19969714
116* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.19604332
117MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19112820
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.18872717
119HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18516929
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16694045
121E2F1_21310950_ChIP-Seq_MCF-7_Human1.16657865
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16614814
123TTF2_22483619_ChIP-Seq_HELA_Human1.16033825
124* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14654611
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14035851
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14035851
127AR_21909140_ChIP-Seq_LNCAP_Human1.12807636
128E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11568232
129POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11146226
130ERG_21242973_ChIP-ChIP_JURKAT_Human1.10288219
131* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09912931
132ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09558354
133* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09393233
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08464009
135ZNF274_21170338_ChIP-Seq_K562_Hela1.07898567
136* BCAT_22108803_ChIP-Seq_LS180_Human1.05849996
137TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04992556
138TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04052856
139* NANOG_16153702_ChIP-ChIP_HESCs_Human1.04018978
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03542980
141VDR_21846776_ChIP-Seq_THP-1_Human1.03341957
142SOX9_26525672_Chip-Seq_HEART_Mouse1.03091182
143TP53_18474530_ChIP-ChIP_U2OS_Human1.02897917
144RACK7_27058665_Chip-Seq_MCF-7_Human1.02826515
145NANOG_16518401_ChIP-PET_MESCs_Mouse1.02576953
146MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01867893
147* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01848289
148EST1_17652178_ChIP-ChIP_JURKAT_Human1.00654629
149TCF4_18268006_ChIP-ChIP_LS174T_Human1.00308674
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00081739
151YY1_21170310_ChIP-Seq_MESCs_Mouse0.99183934
152NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98449586
153EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98419780
154HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95795200
155MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95043646
156SMAD4_21799915_ChIP-Seq_A2780_Human0.94115120
157OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93948218
158MYC_18940864_ChIP-ChIP_HL60_Human0.93431635
159RING1B_27294783_Chip-Seq_NPCs_Mouse0.93132073
160AR_25329375_ChIP-Seq_VCAP_Human0.92919978
161SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92526719
162HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92395656
163UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92176980
164RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91609590
165ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91496471
166LXR_22292898_ChIP-Seq_THP-1_Human0.91486919
167TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91408145
168* SOX2_16153702_ChIP-ChIP_HESCs_Human0.91291806
169TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90716315
170MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90555826
171LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90486122
172GABP_17652178_ChIP-ChIP_JURKAT_Human0.90432191
173YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89887339
174CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87622654
175KAP1_27257070_Chip-Seq_ESCs_Mouse0.85982705
176THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85608883
177SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.85481831
178ELK3_25401928_ChIP-Seq_HUVEC_Human0.85422623
179KDM5A_27292631_Chip-Seq_BREAST_Human0.85322495
180* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84871803
181CHD1_26751641_Chip-Seq_LNCaP_Human0.84695800

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.00348728
2MP0003136_yellow_coat_color3.66047765
3MP0008057_abnormal_DNA_replication2.97816402
4MP0002653_abnormal_ependyma_morphology2.94951149
5MP0009053_abnormal_anal_canal2.69101593
6MP0003941_abnormal_skin_development2.63110242
7MP0009379_abnormal_foot_pigmentation2.37604809
8MP0002796_impaired_skin_barrier2.35180384
9MP0003705_abnormal_hypodermis_morpholog2.34423353
10MP0000579_abnormal_nail_morphology2.31892824
11MP0004957_abnormal_blastocyst_morpholog2.31631553
12MP0003890_abnormal_embryonic-extraembry2.28798102
13MP0010094_abnormal_chromosome_stability2.12597949
14MP0003119_abnormal_digestive_system2.11157092
15MP0000778_abnormal_nervous_system2.10456717
16MP0002254_reproductive_system_inflammat2.07211572
17MP0001346_abnormal_lacrimal_gland2.05089883
18MP0002249_abnormal_larynx_morphology2.05053468
19MP0005171_absent_coat_pigmentation1.99842288
20MP0010352_gastrointestinal_tract_polyps1.98610248
21MP0003111_abnormal_nucleus_morphology1.97918703
22MP0000537_abnormal_urethra_morphology1.96397476
23MP0003123_paternal_imprinting1.93068503
24MP0001293_anophthalmia1.92233697
25MP0004133_heterotaxia1.88585047
26MP0000762_abnormal_tongue_morphology1.86886169
27MP0004885_abnormal_endolymph1.83422580
28MP0002098_abnormal_vibrissa_morphology1.80592325
29MP0002084_abnormal_developmental_patter1.80421116
30MP0010234_abnormal_vibrissa_follicle1.78673463
31MP0002085_abnormal_embryonic_tissue1.75568082
32MP0000631_abnormal_neuroendocrine_gland1.74518932
33MP0003880_abnormal_central_pattern1.74191436
34MP0000049_abnormal_middle_ear1.70849639
35MP0005076_abnormal_cell_differentiation1.69907321
36MP0003077_abnormal_cell_cycle1.69741883
37MP0003878_abnormal_ear_physiology1.69008879
38MP0005377_hearing/vestibular/ear_phenot1.69008879
39MP0002111_abnormal_tail_morphology1.68226494
40MP0004197_abnormal_fetal_growth/weight/1.68096916
41MP0001849_ear_inflammation1.64819476
42MP0005501_abnormal_skin_physiology1.64475619
43MP0002932_abnormal_joint_morphology1.62619188
44MP0003937_abnormal_limbs/digits/tail_de1.62526537
45MP0003385_abnormal_body_wall1.58104604
46MP0000026_abnormal_inner_ear1.56835112
47MP0003283_abnormal_digestive_organ1.55348383
48MP0005380_embryogenesis_phenotype1.54076544
49MP0001672_abnormal_embryogenesis/_devel1.54076544
50MP0003755_abnormal_palate_morphology1.53649941
51MP0002638_abnormal_pupillary_reflex1.52171173
52MP0005187_abnormal_penis_morphology1.52168281
53MP0006072_abnormal_retinal_apoptosis1.51765658
54MP0000383_abnormal_hair_follicle1.51731575
55MP0003693_abnormal_embryo_hatching1.49493589
56MP0008932_abnormal_embryonic_tissue1.49163674
57MP0005275_abnormal_skin_tensile1.47230140
58MP0003453_abnormal_keratinocyte_physiol1.45765287
59MP0000350_abnormal_cell_proliferation1.44698362
60MP0004233_abnormal_muscle_weight1.42574201
61MP0000432_abnormal_head_morphology1.40870132
62MP0002234_abnormal_pharynx_morphology1.40375147
63MP0001730_embryonic_growth_arrest1.38978262
64MP0005503_abnormal_tendon_morphology1.38921144
65MP0000467_abnormal_esophagus_morphology1.38129405
66MP0000516_abnormal_urinary_system1.37888941
67MP0005367_renal/urinary_system_phenotyp1.37888941
68MP0003935_abnormal_craniofacial_develop1.37719122
69MP0001697_abnormal_embryo_size1.36796552
70MP0004264_abnormal_extraembryonic_tissu1.36764770
71MP0002282_abnormal_trachea_morphology1.36280455
72MP0001485_abnormal_pinna_reflex1.35206446
73MP0010678_abnormal_skin_adnexa1.34918894
74MP0002086_abnormal_extraembryonic_tissu1.34641509
75MP0003942_abnormal_urinary_system1.33253203
76MP0000566_synostosis1.32927164
77MP0000428_abnormal_craniofacial_morphol1.32206430
78MP0003121_genomic_imprinting1.30743016
79MP0005248_abnormal_Harderian_gland1.30411139
80MP0002116_abnormal_craniofacial_bone1.28196148
81MP0008007_abnormal_cellular_replicative1.28137667
82MP0000647_abnormal_sebaceous_gland1.25060492
83MP0009278_abnormal_bone_marrow1.24829433
84MP0006292_abnormal_olfactory_placode1.24450236
85MP0003315_abnormal_perineum_morphology1.23290222
86MP0001879_abnormal_lymphatic_vessel1.23137511
87MP0002088_abnormal_embryonic_growth/wei1.22799842
88MP0003984_embryonic_growth_retardation1.22483791
89MP0002909_abnormal_adrenal_gland1.22382298
90MP0002697_abnormal_eye_size1.21722454
91MP0002114_abnormal_axial_skeleton1.21558421
92MP0003938_abnormal_ear_development1.20607427
93MP0005391_vision/eye_phenotype1.19309365
94MP0001299_abnormal_eye_distance/1.18252448
95MP0005394_taste/olfaction_phenotype1.18237631
96MP0005499_abnormal_olfactory_system1.18237631
97MP0002060_abnormal_skin_morphology1.17440252
98MP0002092_abnormal_eye_morphology1.16883970
99MP0008789_abnormal_olfactory_epithelium1.16588582
100MP0004742_abnormal_vestibular_system1.14458815
101MP0001340_abnormal_eyelid_morphology1.13107790
102MP0002233_abnormal_nose_morphology1.12660279
103MP0009250_abnormal_appendicular_skeleto1.12249978
104MP0001286_abnormal_eye_development1.11750781
105MP0000377_abnormal_hair_follicle1.11557351
106MP0005423_abnormal_somatic_nervous1.10791754
107MP0003122_maternal_imprinting1.10683765
108MP0008058_abnormal_DNA_repair1.10012866
109MP0002938_white_spotting1.09188799
110MP0005197_abnormal_uvea_morphology1.08878341
111MP0001529_abnormal_vocalization1.07662396
112MP0004272_abnormal_basement_membrane1.06681839
113MP0003861_abnormal_nervous_system1.05777442
114MP0000955_abnormal_spinal_cord1.04861652
115MP0005508_abnormal_skeleton_morphology1.04597924
116MP0002080_prenatal_lethality1.01749944
117MP0002009_preneoplasia1.01496017
118MP0001216_abnormal_epidermal_layer1.00937185
119MP0003786_premature_aging0.98608960
120MP0003567_abnormal_fetal_cardiomyocyte0.98530916
121MP0000733_abnormal_muscle_development0.97806193
122MP0002184_abnormal_innervation0.95300547
123MP0005253_abnormal_eye_physiology0.95191757
124MP0009703_decreased_birth_body0.94113619
125MP0000534_abnormal_ureter_morphology0.91461759
126MP0002752_abnormal_somatic_nervous0.91400454
127MP0000678_abnormal_parathyroid_gland0.90987073
128MP0001486_abnormal_startle_reflex0.89687386
129MP0000462_abnormal_digestive_system0.88955079
130MP0002109_abnormal_limb_morphology0.88301663
131MP0002102_abnormal_ear_morphology0.87366520
132MP0002081_perinatal_lethality0.85858482
133MP0003566_abnormal_cell_adhesion0.85757209
134MP0006276_abnormal_autonomic_nervous0.83961830
135MP0010771_integument_phenotype0.82150653
136MP0002152_abnormal_brain_morphology0.81936777
137MP0002751_abnormal_autonomic_nervous0.78520096
138MP0005195_abnormal_posterior_eye0.77884715
139MP0001963_abnormal_hearing_physiology0.76661394
140MP0005646_abnormal_pituitary_gland0.76429831
141MP0001984_abnormal_olfaction0.71960047
142MP0000427_abnormal_hair_cycle0.70175439
143MP0002882_abnormal_neuron_morphology0.69324020
144MP0002095_abnormal_skin_pigmentation0.69160391
145MP0009384_cardiac_valve_regurgitation0.68050942

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.45680263
2Hypotrichosis (HP:0001006)3.58298661
3Selective tooth agenesis (HP:0001592)3.42587143
4Congenital, generalized hypertrichosis (HP:0004540)3.42349950
5Short 4th metacarpal (HP:0010044)3.36960441
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.36960441
7Concave nail (HP:0001598)3.15659905
8Septo-optic dysplasia (HP:0100842)3.11116245
9Ependymoma (HP:0002888)3.07941174
10Split foot (HP:0001839)3.01442194
11Milia (HP:0001056)2.98156598
12Rectal fistula (HP:0100590)2.96157456
13Rectovaginal fistula (HP:0000143)2.96157456
14Medulloblastoma (HP:0002885)2.94918755
15Reticulocytopenia (HP:0001896)2.94371561
16Bilateral microphthalmos (HP:0007633)2.93852898
17Renal duplication (HP:0000075)2.88602072
18Midline defect of the nose (HP:0004122)2.86056529
19Oligodactyly (hands) (HP:0001180)2.83519423
20Neoplasm of striated muscle (HP:0009728)2.77955539
21Supernumerary ribs (HP:0005815)2.75852006
22Abnormality of the 4th metacarpal (HP:0010012)2.75759306
23Short humerus (HP:0005792)2.70689329
24Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.69843569
25Aplasia/hypoplasia of the humerus (HP:0006507)2.69199989
26Neoplasm of the oral cavity (HP:0100649)2.65640682
27Intestinal fistula (HP:0100819)2.65199089
28Abnormality of the phalanges of the 2nd finger (HP:0009541)2.63678979
29Cutaneous finger syndactyly (HP:0010554)2.62418696
30Vertebral fusion (HP:0002948)2.59811141
31Woolly hair (HP:0002224)2.58154973
32Abnormality of cells of the erythroid lineage (HP:0012130)2.57835599
33Astrocytoma (HP:0009592)2.55953541
34Abnormality of the astrocytes (HP:0100707)2.55953541
35Aplasia involving bones of the upper limbs (HP:0009823)2.53931619
36Aplasia of the phalanges of the hand (HP:0009802)2.53931619
37Aplasia involving bones of the extremities (HP:0009825)2.53931619
38Abnormal number of incisors (HP:0011064)2.50720874
39Hemivertebrae (HP:0002937)2.50310558
40Supernumerary bones of the axial skeleton (HP:0009144)2.49716142
41Abnormality of the labia minora (HP:0012880)2.49505535
42High anterior hairline (HP:0009890)2.47973028
43Abnormal number of erythroid precursors (HP:0012131)2.47348776
44Anophthalmia (HP:0000528)2.47342263
45Vaginal fistula (HP:0004320)2.46220901
46Short 5th finger (HP:0009237)2.45459986
47Short hallux (HP:0010109)2.42914715
48Absent radius (HP:0003974)2.42446751
49Abnormality of the ischium (HP:0003174)2.42228483
50Partial duplication of thumb phalanx (HP:0009944)2.39487075
51Pili torti (HP:0003777)2.38859336
52Esophageal atresia (HP:0002032)2.38258471
53Oligodactyly (HP:0012165)2.37912123
54Coronal craniosynostosis (HP:0004440)2.37910628
55Short phalanx of the thumb (HP:0009660)2.36720207
56Broad metatarsal (HP:0001783)2.36149849
57Shawl scrotum (HP:0000049)2.35910287
58Turricephaly (HP:0000262)2.35713854
59Absent septum pellucidum (HP:0001331)2.35423398
60Trigonocephaly (HP:0000243)2.34737696
61Abnormality of the parietal bone (HP:0002696)2.31358845
62Absent forearm bone (HP:0003953)2.30713249
63Aplasia involving forearm bones (HP:0009822)2.30713249
64Cutaneous syndactyly (HP:0012725)2.30666045
65Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.28049968
66Rhabdomyosarcoma (HP:0002859)2.27641773
67Broad thumb (HP:0011304)2.26792373
68Ulnar bowing (HP:0003031)2.24257209
69Abnormality of the distal phalanx of the thumb (HP:0009617)2.23821008
70Aplasia/Hypoplasia of the hallux (HP:0008362)2.21993229
71Annular pancreas (HP:0001734)2.21448758
72Sex reversal (HP:0012245)2.20685466
73Abnormal sex determination (HP:0012244)2.20685466
74Short middle phalanx of the 5th finger (HP:0004220)2.19338579
75Macrocytic anemia (HP:0001972)2.17636912
76Optic nerve hypoplasia (HP:0000609)2.16411555
77Supernumerary spleens (HP:0009799)2.15290603
78Hypoplastic labia majora (HP:0000059)2.14200976
79Morphological abnormality of the middle ear (HP:0008609)2.13633396
80Atresia of the external auditory canal (HP:0000413)2.13283359
81Glioma (HP:0009733)2.12140474
82Hypoplastic ischia (HP:0003175)2.11441185
83Ankyloglossia (HP:0010296)2.10873975
84Lip pit (HP:0100267)2.09990222
85Basal cell carcinoma (HP:0002671)2.09935738
86Bifid tongue (HP:0010297)2.07800196
87Abnormality of the middle phalanges of the toes (HP:0010183)2.06649234
88Missing ribs (HP:0000921)2.06217603
89Fragile nails (HP:0001808)2.05863693
90Colon cancer (HP:0003003)2.05562823
91Abnormality of abdominal situs (HP:0011620)2.05445633
92Abdominal situs inversus (HP:0003363)2.05445633
93Skin tags (HP:0010609)2.02586046
94Facial hemangioma (HP:0000329)2.02390059
95Gastrointestinal atresia (HP:0002589)2.00857256
96Neoplasm of the heart (HP:0100544)2.00327263
97Hamartoma (HP:0010566)1.99521303
98Genital tract atresia (HP:0001827)1.99154909
99Broad hallux (HP:0010055)1.99077151
100Calcaneovalgus deformity (HP:0001848)1.98240053
101Partial duplication of the phalanx of hand (HP:0009999)1.96790058
102Broad toe (HP:0001837)1.96006517
103Abnormality of the salivary glands (HP:0010286)1.95482662
104Anencephaly (HP:0002323)1.94760191
105Abnormality of the labia majora (HP:0012881)1.94424427
106Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.93652029
107Preaxial foot polydactyly (HP:0001841)1.93418884
108Patellar aplasia (HP:0006443)1.93241055
109Skin pits (HP:0100276)1.91437020
110Down-sloping shoulders (HP:0200021)1.91283344
111Abnormality of the aortic arch (HP:0012303)1.91197169
112Fused cervical vertebrae (HP:0002949)1.91102909
113Pancreatic fibrosis (HP:0100732)1.91068333
114Aplasia/Hypoplasia of the patella (HP:0006498)1.90224625
115Nail dystrophy (HP:0008404)1.90208921
116Nephronophthisis (HP:0000090)1.89464061
117Morphological abnormality of the inner ear (HP:0011390)1.89419472
118Abnormality of the septum pellucidum (HP:0007375)1.88938847
119Abnormality of the nasolacrimal system (HP:0000614)1.88904719
120Alopecia of scalp (HP:0002293)1.88403890
121Pseudobulbar signs (HP:0002200)1.88385117
122Sparse scalp hair (HP:0002209)1.88102908
123Abnormal lung lobation (HP:0002101)1.87100232
124Stenosis of the external auditory canal (HP:0000402)1.86569559
125Hypoplasia of the ulna (HP:0003022)1.85457595
126Maternal diabetes (HP:0009800)1.85294503
127Squamous cell carcinoma (HP:0002860)1.84362720
128Vaginal atresia (HP:0000148)1.82394588
129Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.82158975
130Trismus (HP:0000211)1.81198199
131Abnormality of the nasal septum (HP:0000419)1.81082967
132Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80895459
133Carpal synostosis (HP:0009702)1.80343640
134Preauricular skin tag (HP:0000384)1.80331333
135Aplasia/Hypoplasia of the sternum (HP:0006714)1.79391374
136Plantar hyperkeratosis (HP:0007556)1.79314645
137Nephroblastoma (Wilms tumor) (HP:0002667)1.78631882
138Aqueductal stenosis (HP:0002410)1.78092080
139Hypochromic microcytic anemia (HP:0004840)1.76976920
140Intestinal atresia (HP:0011100)1.75176762
141Choanal stenosis (HP:0000452)1.73912633
142Hepatoblastoma (HP:0002884)1.73341313
143Humeroradial synostosis (HP:0003041)1.73093552
144Synostosis involving the elbow (HP:0003938)1.73093552
145Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.72903970
146Broad phalanges of the hand (HP:0009768)1.72048674
147Shallow orbits (HP:0000586)1.71600452
148White forelock (HP:0002211)1.71032602
149Abnormality of nail color (HP:0100643)1.70676985
150Abnormality of the pubic bones (HP:0003172)1.68056843
151Wide anterior fontanel (HP:0000260)1.68021304
152Labial hypoplasia (HP:0000066)1.67149674
153Depressed nasal tip (HP:0000437)1.66848873
154Myelomeningocele (HP:0002475)1.66208056
155Deformed tarsal bones (HP:0008119)1.64579833
156Alacrima (HP:0000522)1.64366919
157Duplication of thumb phalanx (HP:0009942)1.64204985
158Abnormality of midbrain morphology (HP:0002418)1.64024546
159Molar tooth sign on MRI (HP:0002419)1.64024546
160Abnormality of the lacrimal duct (HP:0011481)1.64007604
161Triphalangeal thumb (HP:0001199)1.63786436
162Long nose (HP:0003189)1.63618008
163Abnormality of the 2nd finger (HP:0004100)1.63594284
164Cupped ear (HP:0000378)1.62265001
165Abnormality of the renal medulla (HP:0100957)1.61869941
166Anterior segment dysgenesis (HP:0007700)1.60988668
167Aplasia/hypoplasia of the uterus (HP:0008684)1.60893687
168Meningocele (HP:0002435)1.60860947
169True hermaphroditism (HP:0010459)1.60787254
170Patchy hypopigmentation of hair (HP:0011365)1.58727920
171Tracheomalacia (HP:0002779)1.58418688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.63696625
2ICK4.14088192
3PNCK3.95018628
4DDR23.10563353
5CASK2.64233184
6CDC72.60238885
7TYRO32.57693808
8EPHA32.57026993
9MAP3K102.52297053
10EPHA22.42575176
11LATS22.34466978
12CDK72.26861171
13RPS6KB22.26823165
14TTK2.06649591
15LATS11.98518432
16TNIK1.92205092
17WNK31.86574362
18AKT31.84627914
19MAP3K41.80983504
20PDGFRA1.78389264
21MAP3K61.77347326
22VRK21.76634920
23STK241.69641238
24NEK21.66852679
25BMX1.65377147
26MARK11.59744229
27MATK1.57726260
28EPHA41.56709018
29STK391.55925753
30MKNK11.54205023
31VRK11.53694508
32WEE11.50963868
33PLK11.50803802
34BUB11.50680752
35NME11.48981481
36NEK11.46367241
37CDK31.45682748
38CDK61.44662671
39SRPK11.44205944
40CHEK21.43999261
41MAPK151.42447091
42MAP2K71.39349005
43EPHB21.31923866
44DYRK31.29446317
45DYRK1B1.29419384
46TRIM281.29419130
47PAK41.27790957
48NUAK11.26548282
49EEF2K1.25121753
50MTOR1.24889577
51MAP3K111.21765509
52BRD41.17515775
53CAMK1G1.16309375
54FGR1.15148342
55MKNK21.13188508
56NTRK11.09224065
57CHEK11.06684262
58ATR1.06665193
59FGFR11.06476407
60PRKCI1.04472592
61YES11.03782906
62UHMK11.01452258
63PAK31.01191231
64TSSK60.99460319
65KSR10.98872390
66ALK0.98826418
67NLK0.98030856
68CDK40.94733928
69AURKB0.94193891
70STK100.93467073
71CDK20.92908275
72CDK80.92031163
73ZAK0.90878219
74BMPR1B0.89839808
75PLK40.89696662
76TLK10.89585835
77STK38L0.88374282
78PASK0.88106520
79MET0.86052086
80MAPKAPK30.84830825
81AURKA0.84122721
82OXSR10.82187467
83TAF10.81177666
84PRKD20.81069306
85FGFR20.81049529
86MAP3K80.80409959
87RPS6KA40.80291749
88AKT20.79460190
89ATM0.78594304
90GRK60.76418155
91MAP2K40.75215388
92PIM10.73304426
93PINK10.72553979
94ERBB30.72244571
95CAMK1D0.71053803
96STK30.71039847
97RIPK10.71026660
98PLK30.69464470
99DAPK10.68775688
100CCNB10.68638787
101TAOK20.67710617
102CDK10.66304763
103CSNK1E0.65745599
104PTK20.65384729
105PRKCG0.63494818
106SIK20.62454971
107ERBB20.60427280
108GSK3A0.60076039
109RPS6KL10.58710578
110RPS6KC10.58710578
111SGK4940.57866825
112SGK2230.57866825
113TRIB30.54689417
114CSK0.54435311
115DYRK20.52483693
116MAPK130.52408347
117STK110.52230856
118FER0.52170346
119TGFBR10.52142202
120IRAK20.51944908
121MINK10.51940972
122RPS6KA10.51519913
123PAK20.51108780
124ADRBK20.50648873
125SIK10.50469977
126IRAK10.49488999
127MAP3K30.49216022
128MAPK140.47954451
129PIM20.46966763
130NTRK30.46130673
131MAPK10.45913115
132MAPK70.45489129
133CSNK1D0.44952061
134STK40.44116728
135CSNK2A20.43972952
136TTN0.42886692
137CDC42BPA0.42813664
138PTK60.42557039
139BCR0.42041592
140ADRBK10.41874423
141CSNK2A10.41629420
142AKT10.40467952
143MELK0.39501312
144RPS6KA60.39500165
145GSK3B0.37874556
146SGK20.37748134
147NTRK20.36424959
148PRKDC0.36259118
149STK160.32647913
150BRSK20.32606267
151MUSK0.32484733
152MAP4K20.31950167
153PLK20.31549990
154PRKCE0.29996218
155INSRR0.29781746
156GRK10.28784920
157PKN10.27322335
158CLK10.27219784
159MAPKAPK50.27008103
160PRKG10.26702685
161ILK0.26137328
162DYRK1A0.25292783
163MAP3K20.24112866
164PRKACA0.23373237

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.77158699
2* Basal cell carcinoma_Homo sapiens_hsa052173.74571670
3Hedgehog signaling pathway_Homo sapiens_hsa043403.55465798
4DNA replication_Homo sapiens_hsa030303.37910252
5Oxidative phosphorylation_Homo sapiens_hsa001903.29624844
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12295809
7Parkinsons disease_Homo sapiens_hsa050122.99185785
8Spliceosome_Homo sapiens_hsa030402.97584070
9RNA transport_Homo sapiens_hsa030132.85172626
10Base excision repair_Homo sapiens_hsa034102.82911458
11* Hippo signaling pathway_Homo sapiens_hsa043902.70538183
12mRNA surveillance pathway_Homo sapiens_hsa030152.50392551
13Cardiac muscle contraction_Homo sapiens_hsa042602.50044374
14Cell cycle_Homo sapiens_hsa041102.32820684
15* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.25024767
16Huntingtons disease_Homo sapiens_hsa050162.23329447
17Notch signaling pathway_Homo sapiens_hsa043302.11941113
18Protein export_Homo sapiens_hsa030602.04336300
19Nucleotide excision repair_Homo sapiens_hsa034202.02239567
20Ribosome_Homo sapiens_hsa030102.02067399
21Alzheimers disease_Homo sapiens_hsa050102.01110550
22p53 signaling pathway_Homo sapiens_hsa041151.86950405
23Adherens junction_Homo sapiens_hsa045201.85693052
24One carbon pool by folate_Homo sapiens_hsa006701.81020080
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77193860
26* Wnt signaling pathway_Homo sapiens_hsa043101.75305653
27Fanconi anemia pathway_Homo sapiens_hsa034601.73427676
28Homologous recombination_Homo sapiens_hsa034401.73346129
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72294913
30TGF-beta signaling pathway_Homo sapiens_hsa043501.66142015
31MicroRNAs in cancer_Homo sapiens_hsa052061.60621924
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57654656
33Thyroid cancer_Homo sapiens_hsa052161.51950824
34Folate biosynthesis_Homo sapiens_hsa007901.50942717
35Nitrogen metabolism_Homo sapiens_hsa009101.46713384
36mTOR signaling pathway_Homo sapiens_hsa041501.44108241
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42472222
38Bladder cancer_Homo sapiens_hsa052191.41158393
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36808876
40Nicotine addiction_Homo sapiens_hsa050331.31623029
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30378264
42Tight junction_Homo sapiens_hsa045301.29376120
43Fatty acid biosynthesis_Homo sapiens_hsa000611.28070875
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23095354
45RNA polymerase_Homo sapiens_hsa030201.20825253
46Colorectal cancer_Homo sapiens_hsa052101.20053697
47RNA degradation_Homo sapiens_hsa030181.18930753
48* Proteoglycans in cancer_Homo sapiens_hsa052051.18003610
49Cocaine addiction_Homo sapiens_hsa050301.14807105
50Oocyte meiosis_Homo sapiens_hsa041141.10456710
51* Pathways in cancer_Homo sapiens_hsa052001.09160484
52Basal transcription factors_Homo sapiens_hsa030221.06415760
53Small cell lung cancer_Homo sapiens_hsa052221.06046448
54Endometrial cancer_Homo sapiens_hsa052131.04252871
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02357001
56* HTLV-I infection_Homo sapiens_hsa051661.01800443
57Taste transduction_Homo sapiens_hsa047420.98841425
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94471334
59Lysine degradation_Homo sapiens_hsa003100.90558692
60Circadian entrainment_Homo sapiens_hsa047130.89886715
61Viral carcinogenesis_Homo sapiens_hsa052030.89109550
62* Melanogenesis_Homo sapiens_hsa049160.88971209
63Steroid biosynthesis_Homo sapiens_hsa001000.86792688
64Glutamatergic synapse_Homo sapiens_hsa047240.84934410
65Phototransduction_Homo sapiens_hsa047440.84553469
66Morphine addiction_Homo sapiens_hsa050320.83774923
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82899814
68Melanoma_Homo sapiens_hsa052180.80341103
69Chronic myeloid leukemia_Homo sapiens_hsa052200.79805620
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.79597719
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79558439
72Biosynthesis of amino acids_Homo sapiens_hsa012300.79443755
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.77067699
74GABAergic synapse_Homo sapiens_hsa047270.76317177
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74667226
76VEGF signaling pathway_Homo sapiens_hsa043700.71115728
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70871641
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.70799154
79Axon guidance_Homo sapiens_hsa043600.68546323
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68202313
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67631764
82Systemic lupus erythematosus_Homo sapiens_hsa053220.67300368
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66955782
84Prostate cancer_Homo sapiens_hsa052150.65699465
85Ovarian steroidogenesis_Homo sapiens_hsa049130.65195876
86Fructose and mannose metabolism_Homo sapiens_hsa000510.61195272
87Serotonergic synapse_Homo sapiens_hsa047260.60077000
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59638894
89ECM-receptor interaction_Homo sapiens_hsa045120.58362082
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57689874
91Epstein-Barr virus infection_Homo sapiens_hsa051690.57573269
92cAMP signaling pathway_Homo sapiens_hsa040240.57456646
93Pyrimidine metabolism_Homo sapiens_hsa002400.57203792
94Viral myocarditis_Homo sapiens_hsa054160.56975040
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56902424
96Focal adhesion_Homo sapiens_hsa045100.56251992
97Rap1 signaling pathway_Homo sapiens_hsa040150.56125587
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56022017
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54416805
100Herpes simplex infection_Homo sapiens_hsa051680.54280200
101Renin secretion_Homo sapiens_hsa049240.53940528
102Purine metabolism_Homo sapiens_hsa002300.53110136
103Cholinergic synapse_Homo sapiens_hsa047250.52744699
104Acute myeloid leukemia_Homo sapiens_hsa052210.52536976
105Non-small cell lung cancer_Homo sapiens_hsa052230.51275528
106Dilated cardiomyopathy_Homo sapiens_hsa054140.48747769
107ErbB signaling pathway_Homo sapiens_hsa040120.48744329
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46891306
109Non-homologous end-joining_Homo sapiens_hsa034500.46030484
110Selenocompound metabolism_Homo sapiens_hsa004500.45177550
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44535611
112Dorso-ventral axis formation_Homo sapiens_hsa043200.44346647
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44237624
114Insulin secretion_Homo sapiens_hsa049110.43548706
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41990010
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.41117961
117Olfactory transduction_Homo sapiens_hsa047400.40620160
118Gap junction_Homo sapiens_hsa045400.40539577
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39765885
120AMPK signaling pathway_Homo sapiens_hsa041520.39672123
121Propanoate metabolism_Homo sapiens_hsa006400.38312554
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37968287
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.37693975
124Sulfur relay system_Homo sapiens_hsa041220.37180557
125Calcium signaling pathway_Homo sapiens_hsa040200.37003025
126Butanoate metabolism_Homo sapiens_hsa006500.36429073
127Thyroid hormone synthesis_Homo sapiens_hsa049180.36230319
128Proteasome_Homo sapiens_hsa030500.35720128
129Protein digestion and absorption_Homo sapiens_hsa049740.34095482
130Amoebiasis_Homo sapiens_hsa051460.33697708
131Alcoholism_Homo sapiens_hsa050340.33375392
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32657659
133Amphetamine addiction_Homo sapiens_hsa050310.31902174
134Oxytocin signaling pathway_Homo sapiens_hsa049210.31288807
135Linoleic acid metabolism_Homo sapiens_hsa005910.31234807
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31171085
137Bile secretion_Homo sapiens_hsa049760.31050708
138MAPK signaling pathway_Homo sapiens_hsa040100.30645483
139Circadian rhythm_Homo sapiens_hsa047100.29892116
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29555398
141Dopaminergic synapse_Homo sapiens_hsa047280.27871583
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26958941
143Pancreatic cancer_Homo sapiens_hsa052120.26504942
144Pyruvate metabolism_Homo sapiens_hsa006200.25904970
145Shigellosis_Homo sapiens_hsa051310.25843123
146Choline metabolism in cancer_Homo sapiens_hsa052310.25226592
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25132860
148Glioma_Homo sapiens_hsa052140.24114430
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.24083825
150Arachidonic acid metabolism_Homo sapiens_hsa005900.23808996
151Apoptosis_Homo sapiens_hsa042100.23664721
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22354329
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22003580
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21754043
155Insulin signaling pathway_Homo sapiens_hsa049100.20512520

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