FZD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lung epithelium development (GO:0060428)5.39511391
2axonal fasciculation (GO:0007413)5.30395102
3presynaptic membrane assembly (GO:0097105)5.28875716
4dendritic spine morphogenesis (GO:0060997)5.05042563
5presynaptic membrane organization (GO:0097090)4.96634207
6pyrimidine nucleobase catabolic process (GO:0006208)4.93565121
7negative regulation of axon guidance (GO:1902668)4.88732658
8limb bud formation (GO:0060174)4.53791238
9response to pheromone (GO:0019236)4.46731334
10neuron recognition (GO:0008038)4.42308568
11negative regulation of axon extension involved in axon guidance (GO:0048843)4.26185602
12positive regulation of oligodendrocyte differentiation (GO:0048714)4.17675065
13dopaminergic neuron differentiation (GO:0071542)4.13372137
14establishment of nucleus localization (GO:0040023)4.11742929
15central nervous system projection neuron axonogenesis (GO:0021952)4.07311546
16astrocyte differentiation (GO:0048708)3.96977402
17behavioral response to nicotine (GO:0035095)3.96465609
18retinal ganglion cell axon guidance (GO:0031290)3.87584261
19negative regulation of oligodendrocyte differentiation (GO:0048715)3.85836180
20neuron fate determination (GO:0048664)3.84141819
21embryonic foregut morphogenesis (GO:0048617)3.83076197
22axon extension involved in axon guidance (GO:0048846)3.80640445
23neuron projection extension involved in neuron projection guidance (GO:1902284)3.80640445
24negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.79440303
25nonmotile primary cilium assembly (GO:0035058)3.76143281
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.75114057
27regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.71445931
28neuronal stem cell maintenance (GO:0097150)3.69996910
29urogenital system development (GO:0001655)3.60757773
30midbrain development (GO:0030901)3.57241994
31somite development (GO:0061053)3.57198528
32nucleobase catabolic process (GO:0046113)3.56975693
33positive regulation of gastrulation (GO:2000543)3.56312959
34negative chemotaxis (GO:0050919)3.55569833
35regulation of axon guidance (GO:1902667)3.53995098
36lateral sprouting from an epithelium (GO:0060601)3.53935520
37cell proliferation involved in metanephros development (GO:0072203)3.53556028
38intraciliary transport (GO:0042073)3.49725722
39regulation of oligodendrocyte differentiation (GO:0048713)3.47566937
40artery development (GO:0060840)3.45632516
41regulation of mesenchymal cell apoptotic process (GO:2001053)3.37854382
42negative regulation of axon extension (GO:0030517)3.36383870
43neuron cell-cell adhesion (GO:0007158)3.36228495
44epithelial cilium movement (GO:0003351)3.36143228
45auditory behavior (GO:0031223)3.35675259
46transmission of nerve impulse (GO:0019226)3.34695231
47calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.34148811
48innervation (GO:0060384)3.34005968
49forebrain neuron differentiation (GO:0021879)3.33692747
50regulation of chemokine-mediated signaling pathway (GO:0070099)3.31914287
51vocalization behavior (GO:0071625)3.30190024
52neuroblast proliferation (GO:0007405)3.26877506
53myotube differentiation (GO:0014902)3.26581446
54lung-associated mesenchyme development (GO:0060484)3.23447359
55cell migration in hindbrain (GO:0021535)3.21227833
56positive regulation of synapse assembly (GO:0051965)3.20433418
57cranial nerve morphogenesis (GO:0021602)3.15422329
58spinal cord development (GO:0021510)3.14458718
59cell proliferation in forebrain (GO:0021846)3.13867967
60synapse assembly (GO:0007416)3.13402995
61cerebral cortex radially oriented cell migration (GO:0021799)3.11948037
62olfactory bulb development (GO:0021772)3.11579757
63central nervous system neuron axonogenesis (GO:0021955)3.04379196
64negative regulation of microtubule polymerization (GO:0031115)3.03792696
65cerebellum development (GO:0021549)3.00021454
66regulation of NFAT protein import into nucleus (GO:0051532)2.99799614
67neurotransmitter-gated ion channel clustering (GO:0072578)2.99732065
68thalamus development (GO:0021794)2.99409708
69dendritic spine organization (GO:0097061)2.99405336
70regulation of synapse assembly (GO:0051963)2.99241035
71regulation of axon extension involved in axon guidance (GO:0048841)2.98501856
72positive regulation of embryonic development (GO:0040019)2.96275974
73layer formation in cerebral cortex (GO:0021819)2.95896763
74response to auditory stimulus (GO:0010996)2.95327370
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.94533795
76planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92728548
77cilium movement (GO:0003341)2.90894519
78sequestering of actin monomers (GO:0042989)2.89873861
79appendage development (GO:0048736)2.89050340
80limb development (GO:0060173)2.89050340
81nucleus localization (GO:0051647)2.88295666
82regulation of respiratory system process (GO:0044065)2.85680036
83negative regulation of axonogenesis (GO:0050771)2.85155049
84hindbrain development (GO:0030902)2.84964149
85spinal cord association neuron differentiation (GO:0021527)2.83410535
86regulation of respiratory gaseous exchange (GO:0043576)2.82112120
87axon extension (GO:0048675)2.81884876
88lens fiber cell development (GO:0070307)2.80490493
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.79984309
90startle response (GO:0001964)2.79945044
91paraxial mesoderm development (GO:0048339)2.77565485
92regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76398739
93positive regulation of neuroblast proliferation (GO:0002052)2.76344801
94establishment of mitochondrion localization (GO:0051654)2.75832167
95cilium assembly (GO:0042384)2.73651228
96cilium organization (GO:0044782)2.73016699
97protein localization to synapse (GO:0035418)2.71199623
98adult walking behavior (GO:0007628)2.69405045
99lung lobe morphogenesis (GO:0060463)2.69286903
100protein polyglutamylation (GO:0018095)2.69158923
101central nervous system neuron development (GO:0021954)2.68641919
102negative regulation of smooth muscle cell differentiation (GO:0051151)2.67459245
103neural tube formation (GO:0001841)2.67152224
104protein localization to cilium (GO:0061512)2.66808014
105ephrin receptor signaling pathway (GO:0048013)2.65514051
106homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.65034700
107substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.64971266
108substrate-independent telencephalic tangential migration (GO:0021826)2.64971266
109hippocampus development (GO:0021766)2.64860370
110regulation of long-term neuronal synaptic plasticity (GO:0048169)2.64206815
111mechanosensory behavior (GO:0007638)2.63874868
112smoothened signaling pathway (GO:0007224)2.63427361
113gamma-aminobutyric acid transport (GO:0015812)2.62224676
114regulation of short-term neuronal synaptic plasticity (GO:0048172)2.61441811
115ionotropic glutamate receptor signaling pathway (GO:0035235)2.60271367
116regulation of development, heterochronic (GO:0040034)2.60095958
117dorsal/ventral neural tube patterning (GO:0021904)2.59723338
118negative regulation of organelle assembly (GO:1902116)2.59072537
119* neuron migration (GO:0001764)2.58686362
120G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58460889
121cerebellar Purkinje cell differentiation (GO:0021702)2.58069883
122regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56977712
123central nervous system myelination (GO:0022010)2.56647263
124axon ensheathment in central nervous system (GO:0032291)2.56647263
125cilium morphogenesis (GO:0060271)2.56258824
126synaptic transmission, glutamatergic (GO:0035249)2.56257151
127dendrite morphogenesis (GO:0048813)2.55917634
128neuronal action potential propagation (GO:0019227)2.55295392
129regulation of synapse organization (GO:0050807)2.55161272
130branching involved in salivary gland morphogenesis (GO:0060445)2.54551106
131positive regulation of dendritic spine morphogenesis (GO:0061003)2.54242299
132embryonic hindlimb morphogenesis (GO:0035116)2.53809454
133prostate gland growth (GO:0060736)2.53584007
134renal system development (GO:0072001)2.53372223
135postsynaptic membrane organization (GO:0001941)2.52676789
136mesenchymal cell proliferation (GO:0010463)2.52426568
137negative regulation of chemotaxis (GO:0050922)2.51442157
138negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51251001
139regulation of axon extension (GO:0030516)2.50699386
140tongue development (GO:0043586)2.50161509
141glutamate receptor signaling pathway (GO:0007215)2.48951740
142negative regulation of glial cell differentiation (GO:0045686)2.48205097
143negative regulation of astrocyte differentiation (GO:0048712)2.46420708
144negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.45968801
145regulation of non-canonical Wnt signaling pathway (GO:2000050)2.45864374
146cell differentiation in spinal cord (GO:0021515)2.45610887
147negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.44400445
148negative regulation of translation, ncRNA-mediated (GO:0040033)2.44400445
149regulation of translation, ncRNA-mediated (GO:0045974)2.44400445
150regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.43708386
151kidney morphogenesis (GO:0060993)2.43072868
152otic vesicle formation (GO:0030916)2.41572817
153cerebral cortex cell migration (GO:0021795)2.40831927
154synapse organization (GO:0050808)2.40466320
155positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.40034197
156regulation of timing of cell differentiation (GO:0048505)2.39945125
157head development (GO:0060322)2.38960372
158dorsal/ventral axis specification (GO:0009950)2.38324826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.02370330
2EZH2_27304074_Chip-Seq_ESCs_Mouse3.17167540
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.01448617
4GBX2_23144817_ChIP-Seq_PC3_Human2.95658398
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.81307439
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75456406
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.73470992
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.66137955
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61467922
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56488684
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55411403
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46120205
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45348798
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45348798
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44751981
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43819411
17IGF1R_20145208_ChIP-Seq_DFB_Human2.43760360
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39000543
19* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.32780608
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.32708124
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.26525219
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.22246881
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20184181
24* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.19595515
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16388867
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09877081
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01583348
28RNF2_27304074_Chip-Seq_NSC_Mouse2.00300488
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96569590
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92112719
31VDR_22108803_ChIP-Seq_LS180_Human1.90610439
32REST_21632747_ChIP-Seq_MESCs_Mouse1.87195396
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86319268
34* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81352640
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80446108
36ZNF274_21170338_ChIP-Seq_K562_Hela1.78549156
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73094672
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72701644
39TAF15_26573619_Chip-Seq_HEK293_Human1.65746254
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.65118290
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.62488837
42OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.62090208
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61135289
44P300_19829295_ChIP-Seq_ESCs_Human1.56813273
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56458144
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55967892
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55665527
48* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51323270
49* RING1B_27294783_Chip-Seq_ESCs_Mouse1.50922029
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.44602861
51* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40589601
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40092384
53IRF1_19129219_ChIP-ChIP_H3396_Human1.35124932
54AR_21572438_ChIP-Seq_LNCaP_Human1.34847216
55DROSHA_22980978_ChIP-Seq_HELA_Human1.33387940
56* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32785990
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30373514
58* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29475564
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.29140228
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28929144
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25062891
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.24993681
63* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24669375
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.22791886
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22361882
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22210474
67RUNX2_22187159_ChIP-Seq_PCA_Human1.21268639
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.21148638
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21093180
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.20891450
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19378912
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.19326823
73* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18808054
74ISL1_27105846_Chip-Seq_CPCs_Mouse1.18471702
75* SOX2_16153702_ChIP-ChIP_HESCs_Human1.17098450
76* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16143690
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15969299
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15700498
79CBP_20019798_ChIP-Seq_JUKART_Human1.15700498
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15696833
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15020490
82ER_23166858_ChIP-Seq_MCF-7_Human1.13389223
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.12607360
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12294441
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10610581
86FUS_26573619_Chip-Seq_HEK293_Human1.09839399
87SMAD4_21799915_ChIP-Seq_A2780_Human1.09295069
88* TCF4_23295773_ChIP-Seq_U87_Human1.09237867
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08483421
90TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07632553
91TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07252689
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06997894
93SOX9_26525672_Chip-Seq_HEART_Mouse1.06728240
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06164230
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05653386
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04931529
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03797798
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.03671572
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.03496414
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03220703
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03220703
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.03047010
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02999799
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02389717
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02344493
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.02008793
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01270247
108EWS_26573619_Chip-Seq_HEK293_Human1.01252890
109AHR_22903824_ChIP-Seq_MCF-7_Human1.00735070
110* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00147573
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99698495
112P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99499071
113BCAT_22108803_ChIP-Seq_LS180_Human0.99255936
114* AR_19668381_ChIP-Seq_PC3_Human0.98655877
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98615300
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98382368
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97780779
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96793460
119AR_25329375_ChIP-Seq_VCAP_Human0.94988929
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94762000
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94720744
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94421755
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93453291
124STAT3_23295773_ChIP-Seq_U87_Human0.93264100
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92799885
126CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92519461
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92298101
128ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92247262
129POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.91795753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.22576832
2MP0000566_synostosis4.22377515
3MP0003283_abnormal_digestive_organ3.79130832
4MP0002234_abnormal_pharynx_morphology3.02576780
5MP0010030_abnormal_orbit_morphology2.99200148
6* MP0000778_abnormal_nervous_system2.93997807
7MP0002102_abnormal_ear_morphology2.84202278
8MP0003121_genomic_imprinting2.80662064
9MP0002653_abnormal_ependyma_morphology2.77955883
10MP0000537_abnormal_urethra_morphology2.72380054
11MP0003880_abnormal_central_pattern2.61873087
12MP0003136_yellow_coat_color2.57267895
13MP0004859_abnormal_synaptic_plasticity2.51801438
14MP0000569_abnormal_digit_pigmentation2.08895946
15MP0009053_abnormal_anal_canal1.99136009
16MP0005248_abnormal_Harderian_gland1.96702890
17MP0003890_abnormal_embryonic-extraembry1.85205638
18MP0002282_abnormal_trachea_morphology1.78631413
19MP0004270_analgesia1.78439488
20MP0002751_abnormal_autonomic_nervous1.75950216
21MP0002822_catalepsy1.75235460
22MP0006276_abnormal_autonomic_nervous1.74441016
23MP0003635_abnormal_synaptic_transmissio1.73894132
24MP0002938_white_spotting1.73857732
25MP0004133_heterotaxia1.73762869
26MP0003315_abnormal_perineum_morphology1.62110908
27MP0005646_abnormal_pituitary_gland1.61511282
28MP0002063_abnormal_learning/memory/cond1.61496843
29MP0008961_abnormal_basal_metabolism1.60863294
30MP0006072_abnormal_retinal_apoptosis1.58652586
31MP0003938_abnormal_ear_development1.57658712
32MP0002184_abnormal_innervation1.56328996
33MP0003119_abnormal_digestive_system1.54956517
34* MP0003861_abnormal_nervous_system1.52520782
35MP0005423_abnormal_somatic_nervous1.51387274
36MP0002557_abnormal_social/conspecific_i1.48488763
37MP0004885_abnormal_endolymph1.47237471
38* MP0001529_abnormal_vocalization1.45967460
39MP0000462_abnormal_digestive_system1.45302423
40MP0000631_abnormal_neuroendocrine_gland1.44487144
41MP0008877_abnormal_DNA_methylation1.43068449
42MP0002735_abnormal_chemical_nociception1.42827198
43MP0004142_abnormal_muscle_tone1.40971398
44MP0001346_abnormal_lacrimal_gland1.39129605
45MP0005076_abnormal_cell_differentiation1.38880315
46MP0005645_abnormal_hypothalamus_physiol1.34757044
47MP0005253_abnormal_eye_physiology1.34078020
48MP0002249_abnormal_larynx_morphology1.33919823
49MP0005551_abnormal_eye_electrophysiolog1.31826942
50MP0000049_abnormal_middle_ear1.31722305
51MP0009780_abnormal_chondrocyte_physiolo1.31672661
52MP0000467_abnormal_esophagus_morphology1.31062743
53MP0003942_abnormal_urinary_system1.30095960
54* MP0000955_abnormal_spinal_cord1.29876709
55MP0001486_abnormal_startle_reflex1.29442323
56MP0001485_abnormal_pinna_reflex1.27390101
57* MP0002152_abnormal_brain_morphology1.26589987
58MP0001293_anophthalmia1.26130515
59MP0003115_abnormal_respiratory_system1.24451347
60MP0006292_abnormal_olfactory_placode1.21780436
61MP0005171_absent_coat_pigmentation1.21637862
62MP0002572_abnormal_emotion/affect_behav1.20706062
63MP0001188_hyperpigmentation1.20671063
64MP0004811_abnormal_neuron_physiology1.17697920
65MP0001968_abnormal_touch/_nociception1.16513966
66* MP0000026_abnormal_inner_ear1.16467667
67MP0002116_abnormal_craniofacial_bone1.16287264
68MP0003937_abnormal_limbs/digits/tail_de1.16158404
69MP0008789_abnormal_olfactory_epithelium1.15576329
70MP0002064_seizures1.14856421
71* MP0002882_abnormal_neuron_morphology1.14738850
72MP0008995_early_reproductive_senescence1.12676119
73MP0005391_vision/eye_phenotype1.10792496
74MP0002233_abnormal_nose_morphology1.09788440
75MP0002932_abnormal_joint_morphology1.09717686
76MP0004233_abnormal_muscle_weight1.08309325
77MP0005499_abnormal_olfactory_system1.08235986
78MP0005394_taste/olfaction_phenotype1.08235986
79MP0005377_hearing/vestibular/ear_phenot1.07826193
80MP0003878_abnormal_ear_physiology1.07826193
81MP0003755_abnormal_palate_morphology1.07662693
82MP0005195_abnormal_posterior_eye1.07441612
83MP0000383_abnormal_hair_follicle1.07346045
84MP0001984_abnormal_olfaction1.06902756
85MP0009745_abnormal_behavioral_response1.05072267
86MP0004742_abnormal_vestibular_system1.02692629
87MP0009379_abnormal_foot_pigmentation1.00783213
88MP0002734_abnormal_mechanical_nocicepti1.00090738
89MP0005187_abnormal_penis_morphology0.99077997
90MP0002638_abnormal_pupillary_reflex0.98759442
91MP0001963_abnormal_hearing_physiology0.96920307
92MP0000534_abnormal_ureter_morphology0.95720316
93MP0001970_abnormal_pain_threshold0.95308227
94MP0003567_abnormal_fetal_cardiomyocyte0.93778558
95MP0002067_abnormal_sensory_capabilities0.93185295
96MP0001299_abnormal_eye_distance/0.91665030
97MP0001286_abnormal_eye_development0.91398774
98MP0003787_abnormal_imprinting0.89031546
99MP0000428_abnormal_craniofacial_morphol0.87514502
100MP0002092_abnormal_eye_morphology0.85974551
101MP0003123_paternal_imprinting0.84155517
102* MP0004924_abnormal_behavior0.83350136
103* MP0005386_behavior/neurological_phenoty0.83350136
104MP0002272_abnormal_nervous_system0.83096002
105* MP0002752_abnormal_somatic_nervous0.83057513
106* MP0002081_perinatal_lethality0.81337887
107MP0003385_abnormal_body_wall0.80615033
108MP0002697_abnormal_eye_size0.79274459
109MP0009046_muscle_twitch0.79004625
110MP0003935_abnormal_craniofacial_develop0.78930753
111MP0001324_abnormal_eye_pigmentation0.78491434
112MP0002066_abnormal_motor_capabilities/c0.75932005
113MP0003137_abnormal_impulse_conducting0.74521255
114MP0001440_abnormal_grooming_behavior0.74003751
115MP0000647_abnormal_sebaceous_gland0.73323975
116MP0002736_abnormal_nociception_after0.72371893
117MP0002084_abnormal_developmental_patter0.71571353
118MP0009250_abnormal_appendicular_skeleto0.70209306
119MP0002733_abnormal_thermal_nociception0.70038320
120MP0002177_abnormal_outer_ear0.68990923
121MP0010678_abnormal_skin_adnexa0.68464059
122* MP0002085_abnormal_embryonic_tissue0.68372661
123MP0001502_abnormal_circadian_rhythm0.67947150

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)3.53902773
2Abnormality of the labia minora (HP:0012880)3.52477361
3Abnormal number of incisors (HP:0011064)3.44858439
4Pancreatic fibrosis (HP:0100732)3.29439431
5Narrow nasal bridge (HP:0000446)3.25116177
6Anophthalmia (HP:0000528)3.23445414
7Molar tooth sign on MRI (HP:0002419)3.22121791
8Abnormality of midbrain morphology (HP:0002418)3.22121791
9Tented upper lip vermilion (HP:0010804)3.10698257
10Pancreatic cysts (HP:0001737)3.06748961
11Nephronophthisis (HP:0000090)3.04778773
12Medial flaring of the eyebrow (HP:0010747)2.92576124
13Failure to thrive in infancy (HP:0001531)2.80896500
14Growth hormone deficiency (HP:0000824)2.78831495
15Optic nerve hypoplasia (HP:0000609)2.77245872
16Labial hypoplasia (HP:0000066)2.76777697
17Maternal diabetes (HP:0009800)2.74121143
18Sleep apnea (HP:0010535)2.61643086
19Protruding tongue (HP:0010808)2.59011122
20Genital tract atresia (HP:0001827)2.57731877
21Specific learning disability (HP:0001328)2.56770917
22Abnormality of the renal medulla (HP:0100957)2.55194676
23Vaginal atresia (HP:0000148)2.55165380
24Polyphagia (HP:0002591)2.54018349
25Chronic hepatic failure (HP:0100626)2.52279538
26Hypoplastic female external genitalia (HP:0012815)2.49025960
27Nephrogenic diabetes insipidus (HP:0009806)2.48405148
28Colon cancer (HP:0003003)2.48014188
29Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.40265141
30Rib fusion (HP:0000902)2.38367432
31Oligodactyly (hands) (HP:0001180)2.37928382
32Postaxial hand polydactyly (HP:0001162)2.37229691
33Focal motor seizures (HP:0011153)2.35831147
34Shoulder girdle muscle weakness (HP:0003547)2.31023227
35Lissencephaly (HP:0001339)2.27051057
36Megalencephaly (HP:0001355)2.26846344
37Anencephaly (HP:0002323)2.24655311
38Sclerocornea (HP:0000647)2.24313563
39Cystic liver disease (HP:0006706)2.23274299
40Hyperglycinemia (HP:0002154)2.20451382
41Oligodactyly (HP:0012165)2.18698388
42Absent septum pellucidum (HP:0001331)2.17586995
43Exotropia (HP:0000577)2.16537941
44Hepatoblastoma (HP:0002884)2.16032436
45Split foot (HP:0001839)2.14999138
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.14848366
47Supernumerary spleens (HP:0009799)2.14469693
48Anteriorly placed anus (HP:0001545)2.14314748
49Abnormality of the astrocytes (HP:0100707)2.10487715
50Astrocytoma (HP:0009592)2.10487715
51Renal duplication (HP:0000075)2.10243091
52Aqueductal stenosis (HP:0002410)2.10077418
53Short 4th metacarpal (HP:0010044)2.07996455
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07996455
55Cortical dysplasia (HP:0002539)2.07040877
56Poor coordination (HP:0002370)2.06901149
57Hemivertebrae (HP:0002937)2.06427926
58Epileptic encephalopathy (HP:0200134)2.01172982
59Type II lissencephaly (HP:0007260)2.01095182
60Ankle clonus (HP:0011448)2.00590548
61High anterior hairline (HP:0009890)2.00052394
62Vitreoretinal degeneration (HP:0000655)1.99066821
63Hypoplastic pelvis (HP:0008839)1.98066424
64Decreased lacrimation (HP:0000633)1.97901217
65Broad foot (HP:0001769)1.97451600
66Esotropia (HP:0000565)1.94850629
67Abnormality of chromosome segregation (HP:0002916)1.94837859
68Focal seizures (HP:0007359)1.94581777
69Anosmia (HP:0000458)1.94282756
70Abnormality of the aortic arch (HP:0012303)1.94213583
71Abnormality of the incisor (HP:0000676)1.93809127
72Excessive salivation (HP:0003781)1.92318965
73Drooling (HP:0002307)1.92318965
74Absent speech (HP:0001344)1.92021014
75Septo-optic dysplasia (HP:0100842)1.91729124
76Abnormality of the 4th metacarpal (HP:0010012)1.91379154
77Short philtrum (HP:0000322)1.91274868
78Alacrima (HP:0000522)1.91229011
79Febrile seizures (HP:0002373)1.91123003
80Esophageal atresia (HP:0002032)1.90734682
81Retinal dysplasia (HP:0007973)1.89886561
82Ependymoma (HP:0002888)1.89481925
83Gait imbalance (HP:0002141)1.89418226
84Abnormal respiratory epithelium morphology (HP:0012253)1.87579424
85Abnormal respiratory motile cilium morphology (HP:0005938)1.87579424
86Abnormal ciliary motility (HP:0012262)1.87178583
87Pachygyria (HP:0001302)1.87080551
88Intestinal atresia (HP:0011100)1.87039303
89Glioma (HP:0009733)1.86837425
90Deep palmar crease (HP:0006191)1.86581017
91Coronal craniosynostosis (HP:0004440)1.86542773
92Anterior segment dysgenesis (HP:0007700)1.86203413
93Preaxial hand polydactyly (HP:0001177)1.86115201
94Gastrointestinal atresia (HP:0002589)1.84979028
95Hemiparesis (HP:0001269)1.84863927
96Abnormal eating behavior (HP:0100738)1.84372384
97Bifid tongue (HP:0010297)1.84052659
98Limb dystonia (HP:0002451)1.83928545
99Obsessive-compulsive behavior (HP:0000722)1.83553065
100Myokymia (HP:0002411)1.82349344
101True hermaphroditism (HP:0010459)1.82193472
102Aplasia/Hypoplasia of the tibia (HP:0005772)1.82188171
103Trigonocephaly (HP:0000243)1.81586600
104Cerebellar dysplasia (HP:0007033)1.80936555
105Patellar aplasia (HP:0006443)1.79710318
106Narrow forehead (HP:0000341)1.79330913
107Abnormality of the septum pellucidum (HP:0007375)1.78562279
108Progressive cerebellar ataxia (HP:0002073)1.78295152
109Congenital primary aphakia (HP:0007707)1.77792655
110Renal dysplasia (HP:0000110)1.77499163
111Atonic seizures (HP:0010819)1.77135229
112Abnormality of the diencephalon (HP:0010662)1.75331039
113Midline defect of the nose (HP:0004122)1.75254131
114Hypoplasia of the brainstem (HP:0002365)1.75022958
115Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75022958
116Elfin facies (HP:0004428)1.73523550
117Neoplasm of the heart (HP:0100544)1.72390691
118Bronchomalacia (HP:0002780)1.72137306
119Abnormal pancreas size (HP:0012094)1.71092871
120Occipital encephalocele (HP:0002085)1.71061856
121Epileptiform EEG discharges (HP:0011182)1.70665008
122Scrotal hypoplasia (HP:0000046)1.69964844
123Abnormality of the labia (HP:0000058)1.69856198
124Agitation (HP:0000713)1.69743319
125Dandy-Walker malformation (HP:0001305)1.69576752
126Decreased testicular size (HP:0008734)1.69479278
127Short tibia (HP:0005736)1.68147291
128Pelvic girdle muscle weakness (HP:0003749)1.67504176
129Synostosis of carpal bones (HP:0005048)1.67265549
130Overriding aorta (HP:0002623)1.67182983
131Male pseudohermaphroditism (HP:0000037)1.66530073
132Mixed hearing impairment (HP:0000410)1.66326095
133Holoprosencephaly (HP:0001360)1.66316085
134Pendular nystagmus (HP:0012043)1.66072091
135EEG with generalized epileptiform discharges (HP:0011198)1.65597208
136Hypsarrhythmia (HP:0002521)1.65580549
137Preaxial foot polydactyly (HP:0001841)1.65497475
138Broad-based gait (HP:0002136)1.65023495
139Open mouth (HP:0000194)1.64717991
140Congenital hepatic fibrosis (HP:0002612)1.64677735
141Abnormal biliary tract physiology (HP:0012439)1.64655285
142Bile duct proliferation (HP:0001408)1.64655285
143Cutaneous finger syndactyly (HP:0010554)1.64497349
144Renal hypoplasia (HP:0000089)1.64041175
145Abnormal respiratory motile cilium physiology (HP:0012261)1.63622910
146Hyperventilation (HP:0002883)1.60584107
147Thickened helices (HP:0000391)1.60435135
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.58556437
149Cutaneous syndactyly (HP:0012725)1.58086055
150Abnormal hair whorl (HP:0010721)1.55904876
151Facial cleft (HP:0002006)1.55135563
152Truncal ataxia (HP:0002078)1.54913522
153Truncus arteriosus (HP:0001660)1.54195350
154Amblyopia (HP:0000646)1.53643307
155Autism (HP:0000717)1.53404877
156Micropenis (HP:0000054)1.52902935
157Volvulus (HP:0002580)1.52671710
158Postaxial foot polydactyly (HP:0001830)1.52543642

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK36.01232637
2KSR15.19356516
3BCR4.33200154
4EPHB24.29184505
5MARK13.65747362
6NTRK22.61009952
7FGFR22.58990834
8PASK2.52771960
9MAP3K92.33687661
10MINK12.15983447
11UHMK12.14759933
12MKNK21.84818265
13IRAK21.80423595
14NTRK31.75377415
15TYRO31.69526198
16DYRK21.68501092
17MAP3K41.66020251
18CDK191.61006911
19TRIM281.59128263
20ERBB21.50530314
21ICK1.49142296
22ERBB31.48080902
23WNK31.45736666
24MAPK151.41961979
25MAP4K21.40985317
26PINK11.40086457
27WEE11.38476540
28MAPK131.37938321
29CASK1.24412357
30VRK11.24381764
31INSRR1.15846626
32FRK1.15043977
33CCNB11.14916186
34MAP2K71.12749212
35IRAK11.07046843
36CDK181.06574182
37DYRK31.05722089
38STK38L1.04746418
39SIK11.02183687
40PAK61.01906126
41EPHA41.00329703
42BRD40.96697358
43ADRBK20.96341291
44GRK10.93217895
45MAP3K120.92750036
46FGFR10.91277706
47CAMK1G0.89930272
48WNK40.86754437
49DYRK1B0.85831975
50BRSK10.83125154
51NUAK10.81565440
52DMPK0.80475671
53NTRK10.78881608
54ZAK0.78373679
55TAOK20.77181017
56CDK140.76864440
57CAMKK10.76519768
58SRPK10.76037946
59DYRK1A0.74883419
60TNIK0.74840258
61PNCK0.73857012
62SGK20.73618516
63PDGFRA0.72860255
64CDK150.72859909
65CDK50.71722642
66CSNK1G20.70833331
67PRKCE0.70230657
68CSNK1G30.70209463
69PAK30.70035527
70CAMK1D0.69997353
71LIMK10.68645609
72PLK40.68413165
73RPS6KA40.68153160
74CSNK1A1L0.67684298
75PKN10.67490159
76BCKDK0.66859224
77MAP2K40.66071526
78PRPF4B0.64778222
79CDK11A0.63804411
80STK390.59624445
81NEK20.58802291
82ROCK20.57827331
83PLK30.57681159
84PLK10.56676108
85CDC70.55494891
86PLK20.55339643
87BRSK20.55125833
88TSSK60.54083134
89MKNK10.53240823
90STK110.51687758
91CDK30.51209790
92BMPR1B0.50878912
93NEK60.50314320
94ATR0.46804539
95AKT30.45310491
96EPHA30.44938312
97ACVR1B0.43359700
98DAPK20.42856423
99SGK2230.42603994
100SGK4940.42603994
101PRKCG0.42480724
102CHEK20.41276985
103MAP3K100.41189046
104CSNK1A10.41112780
105PRKCZ0.40909938
106LATS20.40842005
107OXSR10.40151925
108STK160.38964828
109MAPK90.38509832
110CAMK10.38086573
111SIK20.37857935
112TAF10.37082009
113PRKACA0.36757144
114AKT20.36609698
115LATS10.36264134
116ROCK10.36127272
117PRKACB0.35794342
118CSNK1D0.34523278
119FER0.33795566
120DAPK10.32535766
121CSNK1G10.32201002
122AURKA0.31474886
123CSNK1E0.30685735
124RET0.29928913
125FYN0.29283062
126CAMK2B0.28986566
127CDK10.27826358
128CAMKK20.27797793
129PAK40.27220780
130DDR20.26362217
131TGFBR10.25928721
132FGFR40.23874001
133CAMK2A0.21519783
134CDC42BPA0.21331434

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052173.34931536
2Hedgehog signaling pathway_Homo sapiens_hsa043403.16085757
3Axon guidance_Homo sapiens_hsa043603.11278365
4Nicotine addiction_Homo sapiens_hsa050332.75402346
5* Hippo signaling pathway_Homo sapiens_hsa043902.12277618
6Protein export_Homo sapiens_hsa030602.09669031
7Steroid biosynthesis_Homo sapiens_hsa001002.02312653
8Phototransduction_Homo sapiens_hsa047442.01206332
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00731335
10Notch signaling pathway_Homo sapiens_hsa043301.97422954
11Cocaine addiction_Homo sapiens_hsa050301.93920526
12Circadian entrainment_Homo sapiens_hsa047131.92071925
13* Wnt signaling pathway_Homo sapiens_hsa043101.89497333
14Insulin secretion_Homo sapiens_hsa049111.76259415
15Dopaminergic synapse_Homo sapiens_hsa047281.75582315
16* Melanogenesis_Homo sapiens_hsa049161.74286166
17Butanoate metabolism_Homo sapiens_hsa006501.72540272
18GABAergic synapse_Homo sapiens_hsa047271.72000201
19Amphetamine addiction_Homo sapiens_hsa050311.68752056
20* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.67854830
21Glutamatergic synapse_Homo sapiens_hsa047241.65773370
22Fanconi anemia pathway_Homo sapiens_hsa034601.65391665
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65338566
24Oxidative phosphorylation_Homo sapiens_hsa001901.64384363
25Parkinsons disease_Homo sapiens_hsa050121.57522196
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.57417912
27Synaptic vesicle cycle_Homo sapiens_hsa047211.53553986
28Propanoate metabolism_Homo sapiens_hsa006401.52990319
29Morphine addiction_Homo sapiens_hsa050321.52761936
30Alcoholism_Homo sapiens_hsa050341.51965033
31Oocyte meiosis_Homo sapiens_hsa041141.49057584
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48737052
33Colorectal cancer_Homo sapiens_hsa052101.48093025
34Cardiac muscle contraction_Homo sapiens_hsa042601.47636267
35Gap junction_Homo sapiens_hsa045401.45765634
36Spliceosome_Homo sapiens_hsa030401.44896537
37ErbB signaling pathway_Homo sapiens_hsa040121.43875142
38mRNA surveillance pathway_Homo sapiens_hsa030151.41234688
39Nitrogen metabolism_Homo sapiens_hsa009101.38425982
40Long-term potentiation_Homo sapiens_hsa047201.36284070
41Basal transcription factors_Homo sapiens_hsa030221.36219727
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30364006
43Huntingtons disease_Homo sapiens_hsa050161.27618202
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25897477
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22488581
46Endometrial cancer_Homo sapiens_hsa052131.18594546
47Cholinergic synapse_Homo sapiens_hsa047251.17782588
48RNA degradation_Homo sapiens_hsa030181.15556995
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15428775
50Serotonergic synapse_Homo sapiens_hsa047261.14837800
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14314962
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13176422
53Cell cycle_Homo sapiens_hsa041101.12739871
54Glioma_Homo sapiens_hsa052141.12543169
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12518404
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12090658
57Olfactory transduction_Homo sapiens_hsa047401.10798436
58Type II diabetes mellitus_Homo sapiens_hsa049301.10564439
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08983729
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08420922
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05977532
62Dorso-ventral axis formation_Homo sapiens_hsa043201.03768298
63Estrogen signaling pathway_Homo sapiens_hsa049151.03189927
64Linoleic acid metabolism_Homo sapiens_hsa005911.02480240
65Alzheimers disease_Homo sapiens_hsa050101.02472101
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00099530
67Long-term depression_Homo sapiens_hsa047300.99570787
68Taste transduction_Homo sapiens_hsa047420.99488965
69Homologous recombination_Homo sapiens_hsa034400.97418737
70Oxytocin signaling pathway_Homo sapiens_hsa049210.97044741
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96004745
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94456320
73Renal cell carcinoma_Homo sapiens_hsa052110.93891315
74* MicroRNAs in cancer_Homo sapiens_hsa052060.92964303
75Ribosome_Homo sapiens_hsa030100.92804810
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92106695
77Ether lipid metabolism_Homo sapiens_hsa005650.90464249
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90174087
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88821223
80Salivary secretion_Homo sapiens_hsa049700.88723030
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.86923236
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86292063
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.85649664
84Circadian rhythm_Homo sapiens_hsa047100.85522835
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85135449
86N-Glycan biosynthesis_Homo sapiens_hsa005100.85016374
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82748503
88GnRH signaling pathway_Homo sapiens_hsa049120.82203867
89Non-homologous end-joining_Homo sapiens_hsa034500.81481003
90Vibrio cholerae infection_Homo sapiens_hsa051100.79336655
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78207311
92Choline metabolism in cancer_Homo sapiens_hsa052310.77977287
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77480438
94Renin secretion_Homo sapiens_hsa049240.76572004
95Non-small cell lung cancer_Homo sapiens_hsa052230.75191261
96Adherens junction_Homo sapiens_hsa045200.74890839
97cAMP signaling pathway_Homo sapiens_hsa040240.72825443
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72685821
99Peroxisome_Homo sapiens_hsa041460.71679558
100Bladder cancer_Homo sapiens_hsa052190.71579743
101Calcium signaling pathway_Homo sapiens_hsa040200.69892365
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.69402318
103* Pathways in cancer_Homo sapiens_hsa052000.68771726
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66849181
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66618503
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66053246
107TGF-beta signaling pathway_Homo sapiens_hsa043500.65432890
108RNA polymerase_Homo sapiens_hsa030200.65325206
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63065076
110Tight junction_Homo sapiens_hsa045300.59410366
111Ras signaling pathway_Homo sapiens_hsa040140.59383034
112Chronic myeloid leukemia_Homo sapiens_hsa052200.59199673
113* Proteoglycans in cancer_Homo sapiens_hsa052050.59021747
114beta-Alanine metabolism_Homo sapiens_hsa004100.58796698
115mTOR signaling pathway_Homo sapiens_hsa041500.57316119
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56897199
117DNA replication_Homo sapiens_hsa030300.56693002
118Gastric acid secretion_Homo sapiens_hsa049710.56361523
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56205455
120Base excision repair_Homo sapiens_hsa034100.56120300
121VEGF signaling pathway_Homo sapiens_hsa043700.56067846
122Systemic lupus erythematosus_Homo sapiens_hsa053220.55743673
123Regulation of autophagy_Homo sapiens_hsa041400.54414178
124Mismatch repair_Homo sapiens_hsa034300.53034708
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52537375
126RNA transport_Homo sapiens_hsa030130.51782855
127* HTLV-I infection_Homo sapiens_hsa051660.51623428
128Glucagon signaling pathway_Homo sapiens_hsa049220.51274159
129Nucleotide excision repair_Homo sapiens_hsa034200.51205781
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50761632
131MAPK signaling pathway_Homo sapiens_hsa040100.50114046
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.49960252
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.49653735
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49059651
135Selenocompound metabolism_Homo sapiens_hsa004500.49004577
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.48933588
137Thyroid hormone synthesis_Homo sapiens_hsa049180.48673757
138Insulin signaling pathway_Homo sapiens_hsa049100.48580316
139Rap1 signaling pathway_Homo sapiens_hsa040150.48514236
140Tryptophan metabolism_Homo sapiens_hsa003800.46608387
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46414742
142Pancreatic cancer_Homo sapiens_hsa052120.46193557
143Prion diseases_Homo sapiens_hsa050200.44630129
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41196304
145Caffeine metabolism_Homo sapiens_hsa002320.38568892
146Lysine degradation_Homo sapiens_hsa003100.36005260

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