FZD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)6.04640987
2regulation of sequestering of triglyceride (GO:0010889)5.95888712
3fatty acid transmembrane transport (GO:1902001)5.45175652
4valine metabolic process (GO:0006573)5.29035416
5positive regulation of fatty acid beta-oxidation (GO:0032000)5.04296934
6carnitine shuttle (GO:0006853)5.01118285
7biotin metabolic process (GO:0006768)5.00219684
8triglyceride catabolic process (GO:0019433)4.87818257
9positive regulation of fatty acid oxidation (GO:0046321)4.84526567
10fatty acid beta-oxidation (GO:0006635)4.84385361
11neutral lipid catabolic process (GO:0046461)4.49093888
12acylglycerol catabolic process (GO:0046464)4.49093888
13brown fat cell differentiation (GO:0050873)4.45303911
14fatty acid oxidation (GO:0019395)4.38044944
15alpha-linolenic acid metabolic process (GO:0036109)4.33142173
16lipid oxidation (GO:0034440)4.29548772
17endothelium development (GO:0003158)4.22883606
18fatty acid catabolic process (GO:0009062)4.15582385
19carnitine transmembrane transport (GO:1902603)4.06021157
20white fat cell differentiation (GO:0050872)4.05514907
21regulation of fatty acid oxidation (GO:0046320)4.05004542
22amino-acid betaine transport (GO:0015838)4.00708464
23carnitine transport (GO:0015879)4.00708464
24branched-chain amino acid metabolic process (GO:0009081)3.97718303
25lysine catabolic process (GO:0006554)3.90533560
26lysine metabolic process (GO:0006553)3.90533560
27regulation of fatty acid beta-oxidation (GO:0031998)3.90295613
28branched-chain amino acid catabolic process (GO:0009083)3.87975302
29regulation of cholesterol storage (GO:0010885)3.86420171
302-oxoglutarate metabolic process (GO:0006103)3.85149394
31* retina vasculature morphogenesis in camera-type eye (GO:0061299)3.85033558
32acetyl-CoA metabolic process (GO:0006084)3.78034781
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.77004282
34ovulation from ovarian follicle (GO:0001542)3.70106231
35lymphangiogenesis (GO:0001946)3.66665612
36positive regulation of lipid catabolic process (GO:0050996)3.59398343
37plasma lipoprotein particle clearance (GO:0034381)3.58852549
38monocarboxylic acid catabolic process (GO:0072329)3.55578962
39tricarboxylic acid metabolic process (GO:0072350)3.53241416
40complement activation, alternative pathway (GO:0006957)3.53074404
41blood vessel maturation (GO:0001955)3.52397246
42negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.49614339
43regulation of triglyceride catabolic process (GO:0010896)3.46617052
44quaternary ammonium group transport (GO:0015697)3.45747198
45fatty acid homeostasis (GO:0055089)3.44277493
46lipid particle organization (GO:0034389)3.43934944
47diacylglycerol metabolic process (GO:0046339)3.42518963
48short-chain fatty acid metabolic process (GO:0046459)3.41567724
49triglyceride biosynthetic process (GO:0019432)3.36703541
50vascular endothelial growth factor signaling pathway (GO:0038084)3.31984032
51positive regulation of fatty acid metabolic process (GO:0045923)3.31641734
52acylglycerol biosynthetic process (GO:0046463)3.31489251
53neutral lipid biosynthetic process (GO:0046460)3.31489251
54transcytosis (GO:0045056)3.29711322
55triglyceride homeostasis (GO:0070328)3.29305310
56acylglycerol homeostasis (GO:0055090)3.29305310
57ethanol oxidation (GO:0006069)3.23426823
58tricarboxylic acid cycle (GO:0006099)3.23159864
59triglyceride metabolic process (GO:0006641)3.22031876
60sulfur amino acid catabolic process (GO:0000098)3.18990121
61intracellular lipid transport (GO:0032365)3.17372034
62glycerolipid catabolic process (GO:0046503)3.16782225
63oxaloacetate metabolic process (GO:0006107)3.15000008
64carnitine metabolic process (GO:0009437)3.14955751
65negative regulation of fibrinolysis (GO:0051918)3.13799443
66glomerular filtration (GO:0003094)3.13631331
67acyl-CoA biosynthetic process (GO:0071616)3.10264711
68thioester biosynthetic process (GO:0035384)3.10264711
69L-phenylalanine catabolic process (GO:0006559)3.10194331
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.10194331
71amino-acid betaine metabolic process (GO:0006577)3.09949458
72lipid storage (GO:0019915)3.06834769
73regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.06012804
74acylglycerol metabolic process (GO:0006639)3.04086970
75positive regulation of lipid storage (GO:0010884)3.03974590
76growth hormone receptor signaling pathway (GO:0060396)3.03775291
77NADH metabolic process (GO:0006734)3.03194328
78triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.02803362
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.01595578
80L-phenylalanine metabolic process (GO:0006558)3.01595578
81regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.00028074
82lymph vessel development (GO:0001945)2.99603666
83neutral lipid metabolic process (GO:0006638)2.98532336
84regulation of plasminogen activation (GO:0010755)2.96436073
85cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.95477424
86regulation of lipoprotein metabolic process (GO:0050746)2.94233051
87positive regulation of glomerulus development (GO:0090193)2.93767788
88basement membrane organization (GO:0071711)2.90232116
89negative regulation of protein autophosphorylation (GO:0031953)2.90022076
90succinate metabolic process (GO:0006105)2.87997691
91negative regulation of fatty acid transport (GO:2000192)2.86965843
92renal filtration (GO:0097205)2.86198163
93epoxygenase P450 pathway (GO:0019373)2.86072994
94regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.85611950
95fatty-acyl-CoA biosynthetic process (GO:0046949)2.84939504
96positive regulation of endothelial cell apoptotic process (GO:2000353)2.83669836
97phospholipid homeostasis (GO:0055091)2.83162486
98endothelial cell morphogenesis (GO:0001886)2.83110220
99homocysteine metabolic process (GO:0050667)2.82509747
100cysteine metabolic process (GO:0006534)2.81949886
101positive regulation of cellular response to insulin stimulus (GO:1900078)2.79860247
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.79746860
103fatty-acyl-CoA metabolic process (GO:0035337)2.77964479
104protein carboxylation (GO:0018214)2.77218620
105peptidyl-glutamic acid carboxylation (GO:0017187)2.77218620
106apoptotic cell clearance (GO:0043277)2.76906935
107polyol transport (GO:0015791)2.75643898
108coenzyme A biosynthetic process (GO:0015937)2.75300630
109insulin-like growth factor receptor signaling pathway (GO:0048009)2.73759890
110glyoxylate metabolic process (GO:0046487)2.72096325
111negative regulation of lipase activity (GO:0060192)2.71777350
112positive regulation of triglyceride metabolic process (GO:0090208)2.70993145
113regulation of triglyceride metabolic process (GO:0090207)2.70649202
114cellular response to epinephrine stimulus (GO:0071872)2.69426418
115protein heterotrimerization (GO:0070208)2.68819587
116carboxylic acid catabolic process (GO:0046395)2.67691736
117organic acid catabolic process (GO:0016054)2.67691736
118regulation of triglyceride biosynthetic process (GO:0010866)2.67659649
119response to dietary excess (GO:0002021)2.66671242
120positive regulation of glycolytic process (GO:0045821)2.66129281
121long-chain fatty acid transport (GO:0015909)2.66010607
122blood coagulation, intrinsic pathway (GO:0007597)2.65403781
123regulation of cAMP-dependent protein kinase activity (GO:2000479)2.64639244
124acyl-CoA metabolic process (GO:0006637)2.63605566
125regulation of protein activation cascade (GO:2000257)2.63533812
126regulation of complement activation (GO:0030449)2.60411078
127embryonic retina morphogenesis in camera-type eye (GO:0060059)2.59986274
128regulation of fibrinolysis (GO:0051917)2.59838998
129protein localization to cell surface (GO:0034394)2.59820448
130positive regulation of triglyceride lipase activity (GO:0061365)2.58977218
131positive regulation of lipoprotein lipase activity (GO:0051006)2.58977218
132ethanol metabolic process (GO:0006067)2.54502957
133regulation of glycogen (starch) synthase activity (GO:2000465)2.53501078
134protein-lipid complex remodeling (GO:0034368)2.48208713
135macromolecular complex remodeling (GO:0034367)2.48208713
136plasma lipoprotein particle remodeling (GO:0034369)2.48208713
137very-low-density lipoprotein particle assembly (GO:0034379)2.46527705
138response to epinephrine (GO:0071871)2.45770503
139regulation of cholesterol esterification (GO:0010872)2.45507205
140cell migration involved in heart development (GO:0060973)2.43393826
141positive regulation of glucose import (GO:0046326)2.43171809
142regulation of macrophage derived foam cell differentiation (GO:0010743)2.42539461
143cardiac myofibril assembly (GO:0055003)2.40991001
144response to phenylpropanoid (GO:0080184)2.39040502
145negative regulation of protein activation cascade (GO:2000258)2.37582111
146negative regulation of DNA biosynthetic process (GO:2000279)2.35460215
147cell proliferation involved in metanephros development (GO:0072203)2.32957535
148negative regulation of metanephros development (GO:0072217)2.28895331
149endocardial cushion development (GO:0003197)2.28089801
150regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.28058947
151negative regulation of smooth muscle cell migration (GO:0014912)2.27409869
152positive regulation of cholesterol efflux (GO:0010875)2.26862358
153regulation of apoptotic cell clearance (GO:2000425)2.26469137
154negative regulation of cartilage development (GO:0061037)2.26417988
155negative regulation of blood vessel endothelial cell migration (GO:0043537)2.26270501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.71906152
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.28331505
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.43858547
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.21947506
5CLOCK_20551151_ChIP-Seq_293T_Human3.93455731
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.77169024
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.54892520
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.95746372
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.74659055
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.61835040
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32210283
12EGR1_23403033_ChIP-Seq_LIVER_Mouse1.98545889
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.98523088
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96303216
15TP63_17297297_ChIP-ChIP_HaCaT_Human1.90071562
16EP300_21415370_ChIP-Seq_HL-1_Mouse1.88090639
17GATA1_22025678_ChIP-Seq_K562_Human1.78990196
18PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.73987455
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.70126004
20BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.67427865
21TBX20_22080862_ChIP-Seq_HEART_Mouse1.64709393
22TBX20_22328084_ChIP-Seq_HEART_Mouse1.64709393
23PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64254389
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.63226815
25* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57068999
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55440578
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.51566418
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49934332
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48221353
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.48179974
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47172535
32ZNF263_19887448_ChIP-Seq_K562_Human1.42311302
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39647227
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.37867841
35* CJUN_26792858_Chip-Seq_BT549_Human1.37599531
36* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.37538505
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.35675790
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33984357
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28294287
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.26873942
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24117804
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21654198
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20788395
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20710497
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19847758
46CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19691622
47GBX2_23144817_ChIP-Seq_PC3_Human1.18418745
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16244959
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14774484
50* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14545671
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13371698
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12845235
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12845235
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11267880
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10078211
56* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06734443
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06351341
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.03972147
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00858736
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00281041
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98339657
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95873285
63SMAD_19615063_ChIP-ChIP_OVARY_Human0.95369312
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94771970
65SOX2_20726797_ChIP-Seq_SW620_Human0.94308846
66* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93860377
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92103982
68RXR_22108803_ChIP-Seq_LS180_Human0.91841698
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91391635
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91107935
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90434896
72TP53_16413492_ChIP-PET_HCT116_Human0.90027049
73GATA1_19941826_ChIP-Seq_K562_Human0.88687131
74FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88116333
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87741244
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87605312
77VDR_24787735_ChIP-Seq_THP-1_Human0.87389104
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86723725
79* SMAD3_21741376_ChIP-Seq_HESCs_Human0.85518089
80BCAT_22108803_ChIP-Seq_LS180_Human0.85392157
81GATA4_25053715_ChIP-Seq_YYC3_Human0.85169007
82* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85140651
83AHR_22903824_ChIP-Seq_MCF-7_Human0.84802176
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84581526
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84581526
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84581526
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83767915
88TCF4_18268006_ChIP-ChIP_LS174T_Human0.83744590
89ISL1_27105846_Chip-Seq_CPCs_Mouse0.83732667
90WT1_19549856_ChIP-ChIP_CCG9911_Human0.83616419
91AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83257180
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83190899
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81759425
94HNF4A_19822575_ChIP-Seq_HepG2_Human0.81751489
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80680772
96CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80601746
97* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.80412442
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79846375
99* SMAD4_21741376_ChIP-Seq_HESCs_Human0.79764812
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79398042
101* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79196399
102WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78079829
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78064034
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77430461
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76473204
106P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76353673
107CDX2_20551321_ChIP-Seq_CACO-2_Human0.75408240
108* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.73938648
109* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.73938648
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73274947
111BP1_19119308_ChIP-ChIP_Hs578T_Human0.72202365
112* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.71421140
113GATA2_19941826_ChIP-Seq_K562_Human0.70634395
114SALL1_21062744_ChIP-ChIP_HESCs_Human0.70211806
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.70051414
116GATA3_24758297_ChIP-Seq_MCF-7_Human0.69455950
117* ELK3_25401928_ChIP-Seq_HUVEC_Human0.69252180
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68110670
119BRD4_25478319_ChIP-Seq_HGPS_Human0.67493279
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.67406703
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.67066052
122SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.66658387
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.66282469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.24993390
2MP0005666_abnormal_adipose_tissue3.81249954
3MP0004130_abnormal_muscle_cell3.77900552
4MP0008438_abnormal_cutaneous_collagen3.41424284
5MP0005360_urolithiasis3.24531328
6MP0002139_abnormal_hepatobiliary_system3.18600622
7MP0004185_abnormal_adipocyte_glucose3.04978083
8MP0002837_dystrophic_cardiac_calcinosis3.04379564
9MP0005375_adipose_tissue_phenotype2.80874776
10MP0010329_abnormal_lipoprotein_level2.70444291
11MP0005365_abnormal_bile_salt2.68565195
12MP0010368_abnormal_lymphatic_system2.67557520
13MP0004272_abnormal_basement_membrane2.58540454
14MP0003705_abnormal_hypodermis_morpholog2.57539570
15MP0000013_abnormal_adipose_tissue2.49497579
16MP0002971_abnormal_brown_adipose2.32321280
17MP0005275_abnormal_skin_tensile2.32151228
18MP0001879_abnormal_lymphatic_vessel2.24770604
19MP0003191_abnormal_cellular_cholesterol2.23622271
20MP0002876_abnormal_thyroid_physiology2.17586469
21MP0005085_abnormal_gallbladder_physiolo2.04871083
22MP0000003_abnormal_adipose_tissue2.00999487
23MP0003868_abnormal_feces_composition1.94012337
24MP0000751_myopathy1.83853465
25MP0003252_abnormal_bile_duct1.80976211
26MP0002118_abnormal_lipid_homeostasis1.80513358
27MP0009115_abnormal_fat_cell1.80427991
28MP0003941_abnormal_skin_development1.63783895
29MP0005334_abnormal_fat_pad1.62896478
30MP0005332_abnormal_amino_acid1.62651442
31MP0003828_pulmonary_edema1.62613706
32MP0003646_muscle_fatigue1.59434874
33MP0004084_abnormal_cardiac_muscle1.56978936
34MP0003724_increased_susceptibility_to1.55451045
35MP0006138_congestive_heart_failure1.55279555
36MP0001661_extended_life_span1.52636865
37MP0004215_abnormal_myocardial_fiber1.52313789
38MP0005167_abnormal_blood-brain_barrier1.49674477
39MP0008875_abnormal_xenobiotic_pharmacok1.48783966
40MP0005330_cardiomyopathy1.40426246
41MP0008775_abnormal_heart_ventricle1.39853930
42MP0000609_abnormal_liver_physiology1.38695355
43MP0004036_abnormal_muscle_relaxation1.35385298
44MP0005620_abnormal_muscle_contractility1.34148102
45MP0005409_darkened_coat_color1.32111277
46MP0010030_abnormal_orbit_morphology1.32053486
47MP0005535_abnormal_body_temperature1.29465358
48MP0005385_cardiovascular_system_phenoty1.28614835
49MP0001544_abnormal_cardiovascular_syste1.28614835
50MP0002970_abnormal_white_adipose1.25657576
51MP0003011_delayed_dark_adaptation1.25248842
52* MP0004087_abnormal_muscle_fiber1.22168565
53MP0006054_spinal_hemorrhage1.18211485
54MP0001958_emphysema1.18119869
55MP0009643_abnormal_urine_homeostasis1.17993624
56MP0000750_abnormal_muscle_regeneration1.17927406
57MP0004147_increased_porphyrin_level1.17891186
58MP0002933_joint_inflammation1.15461835
59MP0002972_abnormal_cardiac_muscle1.15375341
60MP0009780_abnormal_chondrocyte_physiolo1.15235853
61MP0005319_abnormal_enzyme/_coenzyme1.15123897
62MP0003186_abnormal_redox_activity1.14769701
63MP0002127_abnormal_cardiovascular_syste1.14190179
64MP0001756_abnormal_urination1.14022603
65MP0009384_cardiac_valve_regurgitation1.13955366
66MP0000749_muscle_degeneration1.10384989
67MP0003959_abnormal_lean_body1.09324415
68* MP0002128_abnormal_blood_circulation1.08367899
69MP0003566_abnormal_cell_adhesion1.07858864
70MP0010630_abnormal_cardiac_muscle1.03788021
71MP0004019_abnormal_vitamin_homeostasis1.03407225
72MP0003279_aneurysm1.02823542
73MP0002138_abnormal_hepatobiliary_system1.01197360
74MP0003950_abnormal_plasma_membrane0.99416910
75MP0008961_abnormal_basal_metabolism0.98944312
76* MP0001614_abnormal_blood_vessel0.98096718
77MP0002332_abnormal_exercise_endurance0.97869456
78MP0005584_abnormal_enzyme/coenzyme_acti0.96788634
79MP0002108_abnormal_muscle_morphology0.95979122
80MP0000343_altered_response_to0.95727951
81MP0001915_intracranial_hemorrhage0.95445790
82MP0002078_abnormal_glucose_homeostasis0.95041923
83MP0002896_abnormal_bone_mineralization0.92758409
84MP0003091_abnormal_cell_migration0.91907406
85MP0004484_altered_response_of0.86263905
86MP0006036_abnormal_mitochondrial_physio0.85405328
87* MP0000759_abnormal_skeletal_muscle0.84654845
88MP0002295_abnormal_pulmonary_circulatio0.83655097
89MP0003045_fibrosis0.83299649
90MP0005448_abnormal_energy_balance0.82493456
91MP0003385_abnormal_body_wall0.82325335
92MP0000230_abnormal_systemic_arterial0.82308224
93MP0005023_abnormal_wound_healing0.80481533
94MP0004043_abnormal_pH_regulation0.79272536
95MP0000266_abnormal_heart_morphology0.78722961
96MP0000733_abnormal_muscle_development0.78594129
97* MP0002925_abnormal_cardiovascular_devel0.78302460
98MP0004233_abnormal_muscle_weight0.78180893
99MP0002168_other_aberrant_phenotype0.77703901
100MP0002166_altered_tumor_susceptibility0.77308885
101MP0005503_abnormal_tendon_morphology0.77030025
102MP0002106_abnormal_muscle_physiology0.76893598
103MP0002060_abnormal_skin_morphology0.76516827
104MP0005508_abnormal_skeleton_morphology0.76458996
105MP0004085_abnormal_heartbeat0.76417421
106MP0005623_abnormal_meninges_morphology0.75677195
107MP0003195_calcinosis0.75134715
108MP0001666_abnormal_nutrient_absorption0.74572675
109MP0000534_abnormal_ureter_morphology0.73895614
110MP0002796_impaired_skin_barrier0.73057488
111MP0005452_abnormal_adipose_tissue0.72603400
112MP0005595_abnormal_vascular_smooth0.72273741
113MP0005369_muscle_phenotype0.71504932
114MP0000249_abnormal_blood_vessel0.71498310
115MP0002269_muscular_atrophy0.71376242
116MP0003948_abnormal_gas_homeostasis0.71070790
117MP0001764_abnormal_homeostasis0.70160723
118MP0005164_abnormal_response_to0.69563972
119MP0001299_abnormal_eye_distance/0.68902422
120MP0000747_muscle_weakness0.68205535
121MP0003300_gastrointestinal_ulcer0.67766268
122MP0004145_abnormal_muscle_electrophysio0.66914610
123MP0003221_abnormal_cardiomyocyte_apopto0.65476620
124MP0005165_increased_susceptibility_to0.65271859
125MP0004782_abnormal_surfactant_physiolog0.65065843
126MP0000767_abnormal_smooth_muscle0.64740345
127MP0000163_abnormal_cartilage_morphology0.64464878
128MP0002136_abnormal_kidney_physiology0.63354279

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)4.93271823
2Oligomenorrhea (HP:0000876)4.46023558
3Acanthosis nigricans (HP:0000956)4.17567483
4Abnormality of glycine metabolism (HP:0010895)4.17290910
5Abnormality of serine family amino acid metabolism (HP:0010894)4.17290910
6Hypoglycemic coma (HP:0001325)4.06290955
7Myoglobinuria (HP:0002913)3.99709318
8Abnormality of fatty-acid metabolism (HP:0004359)3.92263297
9Ketoacidosis (HP:0001993)3.76595869
10Hypertriglyceridemia (HP:0002155)3.74448895
11Ketosis (HP:0001946)3.71541015
12Increased connective tissue (HP:0009025)3.69203181
13Complement deficiency (HP:0004431)3.65445757
14Hypoalphalipoproteinemia (HP:0003233)3.56244808
15Muscle fiber splitting (HP:0003555)3.40408190
16Vascular tortuosity (HP:0004948)3.40238073
17Hyperammonemia (HP:0001987)3.38383184
18Xanthomatosis (HP:0000991)3.31575461
19Difficulty running (HP:0009046)3.30493594
20Arterial tortuosity (HP:0005116)3.29221648
21Joint hemorrhage (HP:0005261)3.25218789
22Broad metatarsal (HP:0001783)3.16257860
23Deep venous thrombosis (HP:0002625)3.14853265
24Rhabdomyolysis (HP:0003201)3.14753314
25Hyperlipoproteinemia (HP:0010980)3.06911022
26Hyperglycinemia (HP:0002154)3.03250540
27Exercise-induced myalgia (HP:0003738)2.95758230
28Dicarboxylic aciduria (HP:0003215)2.93664021
29Abnormality of dicarboxylic acid metabolism (HP:0010995)2.93664021
30Hyporeflexia of lower limbs (HP:0002600)2.93287200
31Type 1 muscle fiber predominance (HP:0003803)2.90104273
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.86390180
33Lymphangioma (HP:0100764)2.83018160
34Hydroxyprolinuria (HP:0003080)2.81479084
35Abnormality of proline metabolism (HP:0010907)2.81479084
36Epidermoid cyst (HP:0200040)2.80439435
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.74724557
38Insulin-resistant diabetes mellitus (HP:0000831)2.74441264
39Right ventricular cardiomyopathy (HP:0011663)2.72917529
40Cervical subluxation (HP:0003308)2.65775968
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.62218029
42Cerebral aneurysm (HP:0004944)2.61681043
43Lipoatrophy (HP:0100578)2.58040121
44Abnormality of purine metabolism (HP:0004352)2.57099150
45Shallow orbits (HP:0000586)2.48780942
46Polycythemia (HP:0001901)2.47233981
47Abnormality of complement system (HP:0005339)2.46168771
48Exercise-induced muscle cramps (HP:0003710)2.45978895
49Myocardial infarction (HP:0001658)2.45635761
50Hypolipoproteinemia (HP:0010981)2.44075854
51Increased variability in muscle fiber diameter (HP:0003557)2.44063432
52Generalized aminoaciduria (HP:0002909)2.43988993
53Abnormality of carpal bone ossification (HP:0006257)2.43495587
54Abnormality of the intrinsic pathway (HP:0010989)2.43286902
55Increased purine levels (HP:0004368)2.43020618
56Hyperuricemia (HP:0002149)2.43020618
57Insulin resistance (HP:0000855)2.42432799
58Prolonged partial thromboplastin time (HP:0003645)2.41955655
59Overgrowth (HP:0001548)2.41570919
60Bone cyst (HP:0012062)2.37975810
61Aortic aneurysm (HP:0004942)2.37811424
62Protrusio acetabuli (HP:0003179)2.35870856
63Hematochezia (HP:0002573)2.35378593
64Nausea (HP:0002018)2.34571397
65Esophageal varix (HP:0002040)2.31791070
66Hypercholesterolemia (HP:0003124)2.26462902
67Proximal tubulopathy (HP:0000114)2.26369244
68Hyperglycemia (HP:0003074)2.25542153
69Skin nodule (HP:0200036)2.25365436
70Asymmetric septal hypertrophy (HP:0001670)2.23804150
71Back pain (HP:0003418)2.22452630
72Soft skin (HP:0000977)2.22020975
73Vertebral compression fractures (HP:0002953)2.21849423
74Cardiovascular calcification (HP:0011915)2.20624660
75Wormian bones (HP:0002645)2.18953399
76Reduced subcutaneous adipose tissue (HP:0003758)2.18377385
77Gout (HP:0001997)2.17406274
78Striae distensae (HP:0001065)2.17405736
79Abnormality of skeletal muscle fiber size (HP:0012084)2.17139367
80Limited hip movement (HP:0008800)2.15697698
81Sudden death (HP:0001699)2.15451139
82Spinal rigidity (HP:0003306)2.13724605
83Glomerulonephritis (HP:0000099)2.13702527
84Ventricular tachycardia (HP:0004756)2.11144120
85Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.10743460
86Muscle stiffness (HP:0003552)2.10481700
87Abnormality of the common coagulation pathway (HP:0010990)2.10339764
88Growth hormone excess (HP:0000845)2.10280343
89Skull defect (HP:0001362)2.10183211
90Muscle fiber inclusion bodies (HP:0100299)2.09072446
91Intrahepatic cholestasis (HP:0001406)2.08831375
92Abnormal cartilage morphology (HP:0002763)2.08514296
93Abnormality of the calf musculature (HP:0001430)2.07510127
94Neck muscle weakness (HP:0000467)2.07250015
95Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06501919
96Mitral stenosis (HP:0001718)2.06109987
97Facial diplegia (HP:0001349)2.05326199
98Calf muscle hypertrophy (HP:0008981)2.03023270
99Premature rupture of membranes (HP:0001788)2.02822083
100Ectopia lentis (HP:0001083)2.02707589
101Aneurysm (HP:0002617)2.02363930
102Aortic dissection (HP:0002647)2.01862810
103Nemaline bodies (HP:0003798)2.01810479
104Visceral angiomatosis (HP:0100761)1.98465813
105Metabolic acidosis (HP:0001942)1.98297233
106Hypoplasia of the iris (HP:0007676)1.97861962
107Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97052337
108Atrioventricular block (HP:0001678)1.95959914
109Potter facies (HP:0002009)1.95490880
110Facial shape deformation (HP:0011334)1.95490880
111Rectal prolapse (HP:0002035)1.95488691
112Wrist flexion contracture (HP:0001239)1.95034319
113Vascular calcification (HP:0004934)1.94280049
114Pulmonary artery stenosis (HP:0004415)1.93519257
115Abnormality of the acetabulum (HP:0003170)1.91002934
116Infantile muscular hypotonia (HP:0008947)1.89040605
117Blue sclerae (HP:0000592)1.88872676
118Neonatal death (HP:0003811)1.87876729
119Abnormal ossification of hand bones (HP:0005921)1.86772309
120Abnormal delivery (HP:0001787)1.85972801
121Bundle branch block (HP:0011710)1.85937386
122Coxa vara (HP:0002812)1.85186106
123Ankle contracture (HP:0006466)1.85049693
124Myotonia (HP:0002486)1.84584088
125Muscle hypertrophy of the lower extremities (HP:0008968)1.84046578
126Hypokalemic alkalosis (HP:0001949)1.83810323
127Hemangiomatosis (HP:0007461)1.83148110
128Hip contracture (HP:0003273)1.83131275
129Increased muscle lipid content (HP:0009058)1.82801268
130Portal hypertension (HP:0001409)1.82653360
131Mildly elevated creatine phosphokinase (HP:0008180)1.81577008
132Pancreatitis (HP:0001733)1.81397865
133Abnormal hand bone ossification (HP:0010660)1.81263931
134Abnormality of serum amino acid levels (HP:0003112)1.81213462
135Mitral valve prolapse (HP:0001634)1.81029794
136Dilated cardiomyopathy (HP:0001644)1.79487294
137Hypoglycemic seizures (HP:0002173)1.78650960
138Venous abnormality (HP:0002624)1.77984680
139Menorrhagia (HP:0000132)1.77981133
140Hepatocellular carcinoma (HP:0001402)1.77424045
141Ovoid vertebral bodies (HP:0003300)1.76278630
142Round ear (HP:0100830)1.76028285
143Delayed CNS myelination (HP:0002188)1.75869462
144Wide anterior fontanel (HP:0000260)1.75592102
145Cavernous hemangioma (HP:0001048)1.75459172
146Cerebral hemorrhage (HP:0001342)1.75148485
147Prenatal maternal abnormality (HP:0002686)1.74810758
148Dilatation of the ascending aorta (HP:0005111)1.74736841
149Systemic lupus erythematosus (HP:0002725)1.74428717
150Abnormal atrioventricular conduction (HP:0005150)1.74416643
151Vomiting (HP:0002013)1.74321322
152Lethargy (HP:0001254)1.74273347
153Abnormality of nucleobase metabolism (HP:0010932)1.73044914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.75589440
2TRIB34.01825114
3CAMK1D3.67345902
4BCKDK3.59056032
5SIK13.12705644
6KDR2.74279816
7CAMK1G2.66861553
8TGFBR22.47621136
9RIPK12.46002760
10PDK32.37308721
11PDK42.37308721
12TTN2.28242651
13AKT32.23930454
14LATS12.19690235
15INSRR2.11125350
16ERN11.94633632
17LMTK21.93451859
18OBSCN1.91937171
19PDK21.90970433
20EEF2K1.81124327
21PDGFRA1.64876489
22FRK1.63297637
23WNK41.61601627
24FGFR21.57667172
25EPHB21.56360436
26PRKAA21.55748982
27MST1R1.55192155
28FGFR41.53385215
29PKN21.52612679
30FGFR31.47615170
31MYLK1.45691793
32PHKG11.41332351
33PHKG21.41332351
34PIK3CA1.27460273
35NEK91.26022839
36DDR21.21920947
37STK38L1.20666496
38MAPKAPK31.15406216
39ICK1.12606131
40FER1.10266561
41MAP2K31.09647743
42PTK61.05441374
43CDK61.01753393
44PTK2B1.00641996
45DMPK0.96587320
46NLK0.92473318
47EPHA20.90118442
48TGFBR10.89631566
49NTRK10.88639690
50PRKAA10.88574142
51MET0.87699816
52WNK30.87000611
53STK30.85045204
54MAP3K70.79806064
55JAK10.78970447
56CAMK10.77859372
57CDK90.76533131
58STK390.75860122
59OXSR10.75754822
60PINK10.74190654
61LATS20.73374408
62MAPK120.71657820
63CDC42BPA0.68874094
64MAP2K10.67142699
65EPHB10.66766096
66PDPK10.65961495
67PRKD10.65825415
68JAK20.65561131
69MAP3K30.65065765
70PRKCH0.64306783
71GSK3A0.63784048
72PDGFRB0.63381895
73ERBB40.63204627
74TRPM70.62166326
75PIK3CG0.61268029
76MTOR0.58499076
77MARK20.58425857
78TYRO30.58005016
79MAP3K60.57499017
80IGF1R0.56977705
81PAK40.56865043
82MAPK110.56392946
83FGFR10.56257148
84RET0.55396886
85MAP2K40.54610955
86PRKD30.54557397
87MAPK40.54316660
88FLT30.49237075
89SGK30.48165581
90PRKG20.46744089
91MAPK70.46277553
92PRKG10.43965363
93NEK10.43049268
94PRKACG0.42584281
95PAK20.42547255
96AKT20.40566697
97WNK10.40373781
98LRRK20.39466131
99PDK10.39022787
100PTK20.38219510
101CSK0.37965864
102TESK10.35915525
103IRAK30.35762866
104STK380.34648850
105ILK0.33597316
106EPHA30.33259304
107STK240.32728482
108ROCK10.31723776
109SGK2230.31320844
110SGK4940.31320844
111GRK50.31264518
112BMX0.30895568
113ABL20.30659088
114INSR0.29925814
115GRK10.29688220
116PRKCE0.29198006
117CDK40.29119842
118CAMK40.27074877
119RPS6KA20.26762220
120PAK30.26544789
121SGK20.26517911
122ADRBK10.26114350
123SRC0.25340124

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.85661052
2PPAR signaling pathway_Homo sapiens_hsa033203.40526809
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.36695978
4Fatty acid degradation_Homo sapiens_hsa000713.30830198
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.10350990
6Fatty acid metabolism_Homo sapiens_hsa012123.05842526
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.81507273
8Fatty acid biosynthesis_Homo sapiens_hsa000612.50637793
9Nitrogen metabolism_Homo sapiens_hsa009102.45406755
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.43012324
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42536628
12Pyruvate metabolism_Homo sapiens_hsa006202.07057864
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.01976696
14Butanoate metabolism_Homo sapiens_hsa006501.98124521
15Tryptophan metabolism_Homo sapiens_hsa003801.94696048
16beta-Alanine metabolism_Homo sapiens_hsa004101.93348436
17Arginine biosynthesis_Homo sapiens_hsa002201.88417136
18Peroxisome_Homo sapiens_hsa041461.82934593
19Glycerolipid metabolism_Homo sapiens_hsa005611.80820924
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76906076
21Carbon metabolism_Homo sapiens_hsa012001.72028454
22Caffeine metabolism_Homo sapiens_hsa002321.60035740
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58202254
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57653846
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.55637427
26Complement and coagulation cascades_Homo sapiens_hsa046101.49222711
27Fat digestion and absorption_Homo sapiens_hsa049751.43144917
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42847131
29Fatty acid elongation_Homo sapiens_hsa000621.33151479
30AMPK signaling pathway_Homo sapiens_hsa041521.29786706
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.29701170
32Phenylalanine metabolism_Homo sapiens_hsa003601.28719788
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21856554
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21626453
35Insulin resistance_Homo sapiens_hsa049311.18089411
36Starch and sucrose metabolism_Homo sapiens_hsa005001.16792098
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16649892
38Staphylococcus aureus infection_Homo sapiens_hsa051501.10346989
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08191827
40Bile secretion_Homo sapiens_hsa049761.07596892
41Tyrosine metabolism_Homo sapiens_hsa003501.06918492
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06122096
43Lysine degradation_Homo sapiens_hsa003101.04034365
44ECM-receptor interaction_Homo sapiens_hsa045120.96755986
45ABC transporters_Homo sapiens_hsa020100.90906712
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.89539712
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82323886
48Insulin signaling pathway_Homo sapiens_hsa049100.80621969
49Protein digestion and absorption_Homo sapiens_hsa049740.80451701
50Biosynthesis of amino acids_Homo sapiens_hsa012300.78182851
51Chemical carcinogenesis_Homo sapiens_hsa052040.78007031
52Sulfur metabolism_Homo sapiens_hsa009200.77907921
53Glucagon signaling pathway_Homo sapiens_hsa049220.77061388
54Retinol metabolism_Homo sapiens_hsa008300.75802921
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75784193
56Circadian rhythm_Homo sapiens_hsa047100.75425015
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71732390
58Focal adhesion_Homo sapiens_hsa045100.71012263
59Vitamin B6 metabolism_Homo sapiens_hsa007500.64741459
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64312966
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63579629
62Histidine metabolism_Homo sapiens_hsa003400.63124769
63Dilated cardiomyopathy_Homo sapiens_hsa054140.60913819
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60519669
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57894687
66Vitamin digestion and absorption_Homo sapiens_hsa049770.57379418
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53302863
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.51802905
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50607700
70Steroid biosynthesis_Homo sapiens_hsa001000.47308921
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.47076820
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46939970
73Adherens junction_Homo sapiens_hsa045200.46647202
74Pentose phosphate pathway_Homo sapiens_hsa000300.46244258
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45209410
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43463295
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42210583
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42162140
79Arginine and proline metabolism_Homo sapiens_hsa003300.41764489
80Ovarian steroidogenesis_Homo sapiens_hsa049130.40937340
81Sulfur relay system_Homo sapiens_hsa041220.40152577
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.39978961
83Prion diseases_Homo sapiens_hsa050200.39576678
84Selenocompound metabolism_Homo sapiens_hsa004500.39375390
85Rap1 signaling pathway_Homo sapiens_hsa040150.37212657
86Renin secretion_Homo sapiens_hsa049240.37186097
87Type II diabetes mellitus_Homo sapiens_hsa049300.37033800
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36151680
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35920370
90Axon guidance_Homo sapiens_hsa043600.35774825
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.35737928
92* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35237939
93Platelet activation_Homo sapiens_hsa046110.34838363
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.34417211
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33423112
96Malaria_Homo sapiens_hsa051440.32560573
97Amoebiasis_Homo sapiens_hsa051460.32519052
98* Hippo signaling pathway_Homo sapiens_hsa043900.32034268
99cAMP signaling pathway_Homo sapiens_hsa040240.30142551
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.29820605
101Other glycan degradation_Homo sapiens_hsa005110.29793015
102Glutathione metabolism_Homo sapiens_hsa004800.27517463
103Small cell lung cancer_Homo sapiens_hsa052220.27192807
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27111671
105* Pathways in cancer_Homo sapiens_hsa052000.26541094
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24898553
107Viral myocarditis_Homo sapiens_hsa054160.24688536
108Fructose and mannose metabolism_Homo sapiens_hsa000510.23751123
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.22775666
110Thyroid hormone synthesis_Homo sapiens_hsa049180.22366256
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20721834
112* Proteoglycans in cancer_Homo sapiens_hsa052050.20616223
113HIF-1 signaling pathway_Homo sapiens_hsa040660.20190383
114Dorso-ventral axis formation_Homo sapiens_hsa043200.19665104
115Tight junction_Homo sapiens_hsa045300.19542331
116Metabolic pathways_Homo sapiens_hsa011000.18602871
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.17826199
118Renin-angiotensin system_Homo sapiens_hsa046140.14541550
119FoxO signaling pathway_Homo sapiens_hsa040680.13395113
120TGF-beta signaling pathway_Homo sapiens_hsa043500.11855703
121mTOR signaling pathway_Homo sapiens_hsa041500.11732504

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