FZD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial fragmentation involved in apoptotic process (GO:0043653)6.59953635
2* branching involved in labyrinthine layer morphogenesis (GO:0060670)6.38313621
3regulation of gene silencing by RNA (GO:0060966)6.18734985
4regulation of posttranscriptional gene silencing (GO:0060147)6.18734985
5regulation of gene silencing by miRNA (GO:0060964)6.18734985
6lung-associated mesenchyme development (GO:0060484)5.81405700
7inner cell mass cell proliferation (GO:0001833)5.15177563
8regulation of mesoderm development (GO:2000380)5.02930195
9nuclear pore complex assembly (GO:0051292)4.89411433
10nuclear pore organization (GO:0006999)4.82161914
11intestinal epithelial cell development (GO:0060576)4.53460168
12positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.47969148
13response to lipoprotein particle (GO:0055094)4.30733142
14centrosome duplication (GO:0051298)4.23472420
15heterochromatin organization (GO:0070828)4.20606741
16cell migration involved in gastrulation (GO:0042074)4.19747424
17prostate gland growth (GO:0060736)4.19335946
18regulation of hippo signaling (GO:0035330)4.09520539
19L-ascorbic acid metabolic process (GO:0019852)4.09005488
20otic vesicle formation (GO:0030916)4.05775532
21positive regulation of SMAD protein import into nucleus (GO:0060391)4.03960221
22trophectodermal cell differentiation (GO:0001829)4.02767085
23pre-miRNA processing (GO:0031054)3.93320410
24negative regulation of telomerase activity (GO:0051974)3.89988588
25serine family amino acid catabolic process (GO:0009071)3.87927453
26regulation of translational fidelity (GO:0006450)3.87458829
27synapsis (GO:0007129)3.85437137
28establishment of apical/basal cell polarity (GO:0035089)3.81458807
29regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.80941702
30ventricular septum development (GO:0003281)3.80267898
31paraxial mesoderm development (GO:0048339)3.77145808
32DNA replication checkpoint (GO:0000076)3.72194110
33signal transduction involved in regulation of gene expression (GO:0023019)3.65515923
34negative regulation of Rho protein signal transduction (GO:0035024)3.61079236
35positive regulation of mitochondrial fission (GO:0090141)3.60971001
36regulation of gene silencing (GO:0060968)3.59574123
37chromatin assembly (GO:0031497)3.58191606
38intestinal absorption (GO:0050892)3.56412425
39pore complex assembly (GO:0046931)3.55882603
40organ growth (GO:0035265)3.54977936
41embryonic process involved in female pregnancy (GO:0060136)3.54531457
42regulation of helicase activity (GO:0051095)3.53433539
43peripheral nervous system axon ensheathment (GO:0032292)3.49879712
44myelination in peripheral nervous system (GO:0022011)3.49879712
45embryonic foregut morphogenesis (GO:0048617)3.49699651
46glycine metabolic process (GO:0006544)3.46194481
47intestinal cholesterol absorption (GO:0030299)3.45850790
48regulation of SMAD protein import into nucleus (GO:0060390)3.42263202
49determination of adult lifespan (GO:0008340)3.41071520
50regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.38900251
51* anterior/posterior axis specification, embryo (GO:0008595)3.37100375
52chromatin remodeling at centromere (GO:0031055)3.36769007
53regulation of histone H3-K9 methylation (GO:0051570)3.35985337
54mitochondrion morphogenesis (GO:0070584)3.31089279
55regulation of integrin activation (GO:0033623)3.29893182
56positive regulation of cardiac muscle cell proliferation (GO:0060045)3.29612396
57regulation of cell proliferation involved in kidney development (GO:1901722)3.26811101
58folic acid-containing compound biosynthetic process (GO:0009396)3.25547106
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.25202112
60mitochondrial fission (GO:0000266)3.24763009
61DNA replication-dependent nucleosome organization (GO:0034723)3.21930903
62DNA replication-dependent nucleosome assembly (GO:0006335)3.21930903
63cellular response to BMP stimulus (GO:0071773)3.19688954
64response to BMP (GO:0071772)3.19688954
65somite development (GO:0061053)3.19581674
66regulation of energy homeostasis (GO:2000505)3.18562139
67regulation of RNA export from nucleus (GO:0046831)3.18400616
68mitotic nuclear envelope disassembly (GO:0007077)3.18082237
69female gonad development (GO:0008585)3.15590485
70positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.14615400
71protein localization to kinetochore (GO:0034501)3.12422737
72mitotic spindle organization (GO:0007052)3.12254834
73dorsal/ventral axis specification (GO:0009950)3.11741871
74somatic hypermutation of immunoglobulin genes (GO:0016446)3.10634950
75somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10634950
76regulation of non-canonical Wnt signaling pathway (GO:2000050)3.09863133
77negative regulation of histone methylation (GO:0031061)3.07796061
78regulation of gastrulation (GO:0010470)3.07502584
79peroxisome fission (GO:0016559)3.06979991
80establishment or maintenance of monopolar cell polarity (GO:0061339)3.05890553
81establishment of monopolar cell polarity (GO:0061162)3.05890553
82histone H2A monoubiquitination (GO:0035518)3.05471902
83regulation of sister chromatid cohesion (GO:0007063)3.05129702
84CENP-A containing nucleosome assembly (GO:0034080)3.05092487
85notochord development (GO:0030903)3.03574858
86negative regulation of androgen receptor signaling pathway (GO:0060766)3.03133501
87positive regulation of cardiac muscle tissue growth (GO:0055023)3.02588308
88embryonic placenta development (GO:0001892)3.02295368
89mitochondrial fusion (GO:0008053)3.00879106
90regulation of cell fate specification (GO:0042659)2.98014858
91DNA unwinding involved in DNA replication (GO:0006268)2.97894207
92branching involved in mammary gland duct morphogenesis (GO:0060444)2.95123006
93nuclear envelope disassembly (GO:0051081)2.93694024
94membrane disassembly (GO:0030397)2.93694024
95regulation of protein polyubiquitination (GO:1902914)2.93294598
96regulation of mitotic spindle organization (GO:0060236)2.92442447
97DNA geometric change (GO:0032392)2.90633978
98regulation of cardiac muscle cell proliferation (GO:0060043)2.89672303
99spindle assembly (GO:0051225)2.89505670
100DNA duplex unwinding (GO:0032508)2.88588247
101polarized epithelial cell differentiation (GO:0030859)2.87347759
102histone exchange (GO:0043486)2.87044277
103epithelial cell-cell adhesion (GO:0090136)2.85067658
104hemidesmosome assembly (GO:0031581)2.84557326
105interferon-gamma secretion (GO:0072643)2.83430614
106spindle assembly involved in mitosis (GO:0090307)2.82515250
107negative regulation of gene silencing (GO:0060969)2.82302309
108cardiac septum development (GO:0003279)2.82152175
109regulation of stem cell maintenance (GO:2000036)2.81388785
110* apoptotic process involved in morphogenesis (GO:0060561)2.81229929
111regulation of inositol phosphate biosynthetic process (GO:0010919)2.80742091
112negative regulation of keratinocyte proliferation (GO:0010839)2.80377326
113regulation of activin receptor signaling pathway (GO:0032925)2.76652067
114mitotic G2/M transition checkpoint (GO:0044818)2.76537830
115cell proliferation in forebrain (GO:0021846)2.75547126
116gland morphogenesis (GO:0022612)2.73819069
117sister chromatid segregation (GO:0000819)2.73747484
118positive regulation of mitotic sister chromatid separation (GO:1901970)2.71982443
119positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71982443
120positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71982443
121positive regulation of chromosome segregation (GO:0051984)2.69836190
122regulation of telomerase activity (GO:0051972)2.67353515
123positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.67273311
124negative regulation of translation, ncRNA-mediated (GO:0040033)2.66889896
125regulation of translation, ncRNA-mediated (GO:0045974)2.66889896
126negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66889896
127histone H4-K12 acetylation (GO:0043983)2.65022398
128dosage compensation (GO:0007549)2.64973300
129hippo signaling (GO:0035329)2.64106899
130mitotic sister chromatid segregation (GO:0000070)2.63735811
131digestive tract morphogenesis (GO:0048546)2.61543953
132response to UV-C (GO:0010225)2.59726894
133lipoprotein transport (GO:0042953)2.58554803
134regulation of spindle organization (GO:0090224)2.58514843
135nodal signaling pathway (GO:0038092)2.57955431
136regulation of telomere maintenance via telomerase (GO:0032210)2.57704579
137positive regulation of heart growth (GO:0060421)2.57415679
138negative regulation of activin receptor signaling pathway (GO:0032926)2.56311878
139mitochondrial respiratory chain complex I assembly (GO:0032981)2.55966599
140NADH dehydrogenase complex assembly (GO:0010257)2.55966599
141mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55966599
142somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.55055790
143somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.55055790
144isotype switching (GO:0045190)2.55055790
145branching involved in salivary gland morphogenesis (GO:0060445)2.55037672
146flavonoid metabolic process (GO:0009812)2.54645735
147DNA double-strand break processing (GO:0000729)2.54258966
148mitotic sister chromatid cohesion (GO:0007064)2.54143658
149mitotic G1 DNA damage checkpoint (GO:0031571)2.53965916
150negative regulation of DNA repair (GO:0045738)2.53444124
151response to gonadotropin (GO:0034698)2.53000579
152prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.52578676
153virion attachment to host cell (GO:0019062)2.52045549
154adhesion of symbiont to host cell (GO:0044650)2.52045549
155* cell differentiation involved in embryonic placenta development (GO:0060706)2.52002840
156IMP biosynthetic process (GO:0006188)2.51950572
157bundle of His cell to Purkinje myocyte communication (GO:0086069)2.49722590
158microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.48968616
159NLS-bearing protein import into nucleus (GO:0006607)2.47664553
160cranial suture morphogenesis (GO:0060363)2.47582091
161negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.45889243
162mitotic G1/S transition checkpoint (GO:0044819)2.45633426
163intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.44215740
164protein localization to chromosome, centromeric region (GO:0071459)2.43777592
165establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.43070693
166negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.43038478
167proline biosynthetic process (GO:0006561)2.42748936
168vitamin A metabolic process (GO:0006776)2.41567326
169intracellular estrogen receptor signaling pathway (GO:0030520)2.41021460
170RNA stabilization (GO:0043489)2.39754371
171mRNA stabilization (GO:0048255)2.39754371
172mitotic chromosome condensation (GO:0007076)2.38570432
173regulation of cholesterol homeostasis (GO:2000188)2.36617415
174regulation of chromatin silencing (GO:0031935)2.35960597
175DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.34030058
176establishment or maintenance of apical/basal cell polarity (GO:0035088)2.33753295
177establishment or maintenance of bipolar cell polarity (GO:0061245)2.33753295
178mitotic metaphase plate congression (GO:0007080)2.32042977
179nuclear envelope organization (GO:0006998)2.31551155
180response to hepatocyte growth factor (GO:0035728)2.31549388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.58291395
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.25128935
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.03055877
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.92979549
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.92979549
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.92979549
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.65895483
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.60329401
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.52247554
10* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.11968850
11* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.97793823
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.86045733
13* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.71831866
14* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.67289378
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.60940660
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.58258145
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.46402227
18NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.44803614
19* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.43300062
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.42230727
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32980008
22NANOG_16153702_ChIP-ChIP_HESCs_Human2.31397211
23STAT3_1855785_ChIP-Seq_MESCs_Mouse2.30666417
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25707068
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25063675
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21635565
27SOX2_16153702_ChIP-ChIP_HESCs_Human2.21115669
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.20980558
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.13025196
30IRF1_19129219_ChIP-ChIP_H3396_Human2.09972982
31* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08862651
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06929058
33* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02100809
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.96096164
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94536953
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91954691
37GATA1_26923725_Chip-Seq_HPCs_Mouse1.91763116
38AR_21909140_ChIP-Seq_LNCAP_Human1.91469985
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.90410555
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.90016370
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.88904696
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.86862970
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.86364927
44NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.80942940
45MYC_18940864_ChIP-ChIP_HL60_Human1.80546949
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.73380347
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69061801
48NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.62506016
49SMAD3_21741376_ChIP-Seq_HESCs_Human1.61016581
50* FUS_26573619_Chip-Seq_HEK293_Human1.56153318
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56005954
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.54768564
53* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.52158857
54* GATA6_25053715_ChIP-Seq_YYC3_Human1.48323008
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.47609331
56* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.44993995
57* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.43652892
58* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.42828552
59* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40288638
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39551362
61LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39526403
62* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38949152
63TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.38865645
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38825898
65* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38795479
66* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37588996
67ZNF263_19887448_ChIP-Seq_K562_Human1.37434236
68* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.36854581
69SMAD4_21741376_ChIP-Seq_HESCs_Human1.31869385
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31431385
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.30448140
72ZNF274_21170338_ChIP-Seq_K562_Hela1.28308417
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28231017
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.27119423
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25613519
76ATF3_27146783_Chip-Seq_COLON_Human1.24235380
77EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.22717331
78* E2F1_21310950_ChIP-Seq_MCF-7_Human1.21980595
79* CDX2_20551321_ChIP-Seq_CACO-2_Human1.20750234
80MYC_22102868_ChIP-Seq_BL_Human1.19223048
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18315783
82TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17411963
83CLOCK_20551151_ChIP-Seq_293T_Human1.17400797
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16867059
85POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.16303086
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15446910
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15089211
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14731304
89* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14716685
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13747900
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10719121
92* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10338134
93* KAP1_27257070_Chip-Seq_ESCs_Mouse1.10163934
94* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09124596
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.08307097
96PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08291312
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08099172
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.06299532
99* P300_19829295_ChIP-Seq_ESCs_Human1.05904130
100* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04738845
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04571098
102* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04312522
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04051501
104* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03518942
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.02788078
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01522227
107TTF2_22483619_ChIP-Seq_HELA_Human1.01093998
108TRIM28_21343339_ChIP-Seq_HEK293_Human1.00894232
109ELK1_19687146_ChIP-ChIP_HELA_Human1.00761623
110FOXP3_21729870_ChIP-Seq_TREG_Human1.00742512
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00082126
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.99929510
113SMAD3_21741376_ChIP-Seq_EPCs_Human0.99719948
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98394146
115RACK7_27058665_Chip-Seq_MCF-7_Human0.98308865
116EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98197612
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97389826
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96549072
119EOMES_21245162_ChIP-Seq_HESCs_Human0.96493419
120* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96237503
121MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96229987
122GATA4_25053715_ChIP-Seq_YYC3_Human0.95813651
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95070010
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95070010
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94554062
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93989974
127CHD1_26751641_Chip-Seq_LNCaP_Human0.93979421
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93931616
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91655578
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91576548
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91183720
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90589601
133* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90396928
134* NANOG_16518401_ChIP-PET_MESCs_Mouse0.88705983
135SMAD4_21741376_ChIP-Seq_EPCs_Human0.88279485
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87483419
137CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86970250
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86402601
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85838094
140ESR2_21235772_ChIP-Seq_MCF-7_Human0.85508677
141HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84879967
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84810386
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84676229
144FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84339491
145RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84174562
146NCOR1_26117541_ChIP-Seq_K562_Human0.83451336
147* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83418461
148* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.82436185
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80815757
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80213105
151KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79517733
152EWS_26573619_Chip-Seq_HEK293_Human0.78451423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.67197697
2MP0003705_abnormal_hypodermis_morpholog3.92942444
3MP0010352_gastrointestinal_tract_polyps3.92436739
4MP0003315_abnormal_perineum_morphology2.99631546
5MP0004264_abnormal_extraembryonic_tissu2.87828943
6MP0010234_abnormal_vibrissa_follicle2.84920437
7MP0005670_abnormal_white_adipose2.62430708
8MP0001485_abnormal_pinna_reflex2.42402657
9MP0004957_abnormal_blastocyst_morpholog2.32445054
10MP0005076_abnormal_cell_differentiation2.32046524
11MP0003136_yellow_coat_color2.25979074
12MP0008057_abnormal_DNA_replication2.24680884
13MP0003941_abnormal_skin_development2.13031477
14MP0000537_abnormal_urethra_morphology2.10960431
15MP0005499_abnormal_olfactory_system2.09670784
16MP0005394_taste/olfaction_phenotype2.09670784
17MP0000049_abnormal_middle_ear2.03894558
18MP0003693_abnormal_embryo_hatching2.01348820
19MP0003111_abnormal_nucleus_morphology1.98453510
20MP0003566_abnormal_cell_adhesion1.96793183
21MP0010030_abnormal_orbit_morphology1.92951745
22MP0010307_abnormal_tumor_latency1.92650503
23MP0008789_abnormal_olfactory_epithelium1.83297758
24MP0004185_abnormal_adipocyte_glucose1.81267763
25MP0003806_abnormal_nucleotide_metabolis1.77168838
26MP0001293_anophthalmia1.75460309
27MP0009053_abnormal_anal_canal1.72654351
28MP0010094_abnormal_chromosome_stability1.72067771
29MP0003077_abnormal_cell_cycle1.70159444
30MP0003950_abnormal_plasma_membrane1.67255617
31MP0005360_urolithiasis1.64009009
32MP0002233_abnormal_nose_morphology1.63528785
33MP0000350_abnormal_cell_proliferation1.62891387
34MP0000462_abnormal_digestive_system1.62785521
35* MP0002086_abnormal_extraembryonic_tissu1.61851755
36MP0003119_abnormal_digestive_system1.60827283
37MP0003453_abnormal_keratinocyte_physiol1.60418898
38MP0005023_abnormal_wound_healing1.58980491
39MP0001730_embryonic_growth_arrest1.58933214
40MP0004197_abnormal_fetal_growth/weight/1.57749812
41MP0002084_abnormal_developmental_patter1.56749980
42MP0001849_ear_inflammation1.56576068
43MP0001672_abnormal_embryogenesis/_devel1.55231265
44MP0005380_embryogenesis_phenotype1.55231265
45MP0002796_impaired_skin_barrier1.53354708
46MP0001661_extended_life_span1.50858105
47MP0003890_abnormal_embryonic-extraembry1.49322206
48MP0010678_abnormal_skin_adnexa1.49080555
49MP0002085_abnormal_embryonic_tissue1.47728166
50MP0002139_abnormal_hepatobiliary_system1.43545923
51MP0003283_abnormal_digestive_organ1.42783088
52MP0003984_embryonic_growth_retardation1.39797242
53MP0003718_maternal_effect1.38969206
54MP0002088_abnormal_embryonic_growth/wei1.37726309
55MP0002697_abnormal_eye_size1.36836234
56MP0005501_abnormal_skin_physiology1.34947971
57MP0002653_abnormal_ependyma_morphology1.33851155
58MP0003938_abnormal_ear_development1.32329763
59MP0001666_abnormal_nutrient_absorption1.32174043
60MP0003122_maternal_imprinting1.28964112
61MP0001697_abnormal_embryo_size1.27570869
62MP0005248_abnormal_Harderian_gland1.25332493
63* MP0000490_abnormal_crypts_of1.24881662
64MP0005275_abnormal_skin_tensile1.24433657
65MP0000516_abnormal_urinary_system1.23974450
66MP0005367_renal/urinary_system_phenotyp1.23974450
67MP0002132_abnormal_respiratory_system1.23704599
68MP0002160_abnormal_reproductive_system1.19768392
69MP0002254_reproductive_system_inflammat1.19302766
70MP0004133_heterotaxia1.18942921
71MP0001299_abnormal_eye_distance/1.18810471
72MP0002938_white_spotting1.18089896
73MP0002092_abnormal_eye_morphology1.15628684
74MP0002098_abnormal_vibrissa_morphology1.13488662
75MP0002751_abnormal_autonomic_nervous1.10692971
76* MP0000477_abnormal_intestine_morphology1.10130553
77MP0000383_abnormal_hair_follicle1.09524647
78MP0004147_increased_porphyrin_level1.09461950
79MP0008438_abnormal_cutaneous_collagen1.09258343
80MP0000566_synostosis1.06170189
81MP0009840_abnormal_foam_cell1.05390705
82MP0002111_abnormal_tail_morphology1.04902640
83MP0002060_abnormal_skin_morphology1.04791250
84MP0003123_paternal_imprinting1.03887632
85MP0005623_abnormal_meninges_morphology1.03103537
86* MP0002080_prenatal_lethality1.02614934
87MP0000627_abnormal_mammary_gland1.02341027
88MP0001286_abnormal_eye_development1.02260958
89MP0003937_abnormal_limbs/digits/tail_de1.02138469
90MP0000432_abnormal_head_morphology1.01485620
91MP0002877_abnormal_melanocyte_morpholog1.00836781
92MP0002138_abnormal_hepatobiliary_system1.00611640
93MP0005377_hearing/vestibular/ear_phenot1.00476604
94MP0003878_abnormal_ear_physiology1.00476604
95MP0008877_abnormal_DNA_methylation0.99119536
96MP0005257_abnormal_intraocular_pressure0.98066423
97MP0008932_abnormal_embryonic_tissue0.97869572
98MP0000631_abnormal_neuroendocrine_gland0.97115909
99MP0000467_abnormal_esophagus_morphology0.95871056
100MP0002009_preneoplasia0.95189187
101MP0003861_abnormal_nervous_system0.94708141
102MP0004272_abnormal_basement_membrane0.94676102
103MP0009672_abnormal_birth_weight0.93876602
104MP0008007_abnormal_cellular_replicative0.93669097
105MP0003195_calcinosis0.92028462
106MP0001216_abnormal_epidermal_layer0.90826022
107MP0005085_abnormal_gallbladder_physiolo0.89827960
108MP0000377_abnormal_hair_follicle0.89738696
109MP0003300_gastrointestinal_ulcer0.89604975
110MP0000579_abnormal_nail_morphology0.87787345
111MP0003567_abnormal_fetal_cardiomyocyte0.87312273
112MP0000733_abnormal_muscle_development0.86364085
113MP0003115_abnormal_respiratory_system0.86052064
114MP0003936_abnormal_reproductive_system0.85753982
115MP0008004_abnormal_stomach_pH0.85127610
116* MP0002925_abnormal_cardiovascular_devel0.84691173
117MP0003091_abnormal_cell_migration0.84384765
118MP0000470_abnormal_stomach_morphology0.84338048
119MP0000762_abnormal_tongue_morphology0.84176570
120MP0002277_abnormal_respiratory_mucosa0.82306657
121MP0003121_genomic_imprinting0.81149450
122MP0003448_altered_tumor_morphology0.81123537
123MP0002282_abnormal_trachea_morphology0.80439728
124MP0005365_abnormal_bile_salt0.79398455
125MP0003755_abnormal_palate_morphology0.78850115
126MP0000013_abnormal_adipose_tissue0.78793985
127MP0009384_cardiac_valve_regurgitation0.78660666
128MP0008058_abnormal_DNA_repair0.76698557
129MP0005666_abnormal_adipose_tissue0.76522997
130MP0009765_abnormal_xenobiotic_induced0.76499301
131MP0000428_abnormal_craniofacial_morphol0.75556506
132MP0006054_spinal_hemorrhage0.75401514
133MP0009703_decreased_birth_body0.74819179
134MP0003935_abnormal_craniofacial_develop0.74605236
135MP0003786_premature_aging0.74515866
136MP0001243_abnormal_dermal_layer0.73737599
137MP0000858_altered_metastatic_potential0.72402186
138MP0002116_abnormal_craniofacial_bone0.69618510
139MP0004858_abnormal_nervous_system0.69532343
140MP0005084_abnormal_gallbladder_morpholo0.69352005
141MP0002234_abnormal_pharynx_morphology0.68572954
142MP0000778_abnormal_nervous_system0.68092126
143MP0008872_abnormal_physiological_respon0.67981684
144MP0003385_abnormal_body_wall0.65879510
145MP0005391_vision/eye_phenotype0.61787516
146MP0000647_abnormal_sebaceous_gland0.61293735
147MP0001177_atelectasis0.59651369
148MP0001119_abnormal_female_reproductive0.59203016
149MP0001145_abnormal_male_reproductive0.58172873

Predicted human phenotypes

RankGene SetZ-score
1Stenosis of the external auditory canal (HP:0000402)6.16983299
2Abnormality of the parathyroid morphology (HP:0011766)5.19721584
3Carpal bone hypoplasia (HP:0001498)4.91760953
4Ectopic kidney (HP:0000086)4.76722662
5Rectovaginal fistula (HP:0000143)4.38442902
6Rectal fistula (HP:0100590)4.38442902
7Ependymoma (HP:0002888)4.20433494
8Vaginal fistula (HP:0004320)4.07364092
9Horseshoe kidney (HP:0000085)3.89932195
10Short hallux (HP:0010109)3.62614124
11Abnormality of the astrocytes (HP:0100707)3.53962078
12Astrocytoma (HP:0009592)3.53962078
13Absent thumb (HP:0009777)3.35701364
14Aplasia/Hypoplasia of the hallux (HP:0008362)3.33337015
15Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.29262262
16Abnormality of the labia minora (HP:0012880)3.27686344
17Osteomalacia (HP:0002749)3.24403205
18Maternal diabetes (HP:0009800)3.20890429
19Duplicated collecting system (HP:0000081)3.20144832
20Ulnar bowing (HP:0003031)3.19390615
21Abnormality of the renal collecting system (HP:0004742)3.16119224
22Reticulocytopenia (HP:0001896)3.11259126
23Choanal stenosis (HP:0000452)3.05823080
24Biliary tract neoplasm (HP:0100574)2.98759228
25Short humerus (HP:0005792)2.97356715
26Neoplasm of the oral cavity (HP:0100649)2.96762330
27Meckel diverticulum (HP:0002245)2.95432967
28Intestinal atresia (HP:0011100)2.94195400
29Preaxial foot polydactyly (HP:0001841)2.92908005
30Esophageal atresia (HP:0002032)2.89433863
31Septo-optic dysplasia (HP:0100842)2.88416288
32Acanthocytosis (HP:0001927)2.85151187
33Rib fusion (HP:0000902)2.84380265
34Short thumb (HP:0009778)2.82983440
35Triphalangeal thumb (HP:0001199)2.82748750
36Synostosis of carpal bones (HP:0005048)2.82205660
37Right ventricular cardiomyopathy (HP:0011663)2.81314525
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.80453002
39Abnormality of the ileum (HP:0001549)2.80274183
40Anophthalmia (HP:0000528)2.79043187
41Aplasia/hypoplasia of the humerus (HP:0006507)2.78121457
42Abnormality of DNA repair (HP:0003254)2.73558489
43Hypoplasia of the ulna (HP:0003022)2.71121228
44Glioma (HP:0009733)2.68475831
45Aplasia/Hypoplasia involving the musculature (HP:0001460)2.67067229
46Ileus (HP:0002595)2.66162561
47Abnormality of the salivary glands (HP:0010286)2.63269371
48Vitreoretinal degeneration (HP:0000655)2.63122854
49Selective tooth agenesis (HP:0001592)2.62599901
50Absent radius (HP:0003974)2.58262633
51Vertebral clefting (HP:0008428)2.56814605
52Hypoalphalipoproteinemia (HP:0003233)2.56779561
53Aqueductal stenosis (HP:0002410)2.55518857
54Oligodactyly (hands) (HP:0001180)2.54710851
55Double outlet right ventricle (HP:0001719)2.54542620
56Congenital malformation of the right heart (HP:0011723)2.54542620
57Metaphyseal cupping (HP:0003021)2.52363548
58Malignant gastrointestinal tract tumors (HP:0006749)2.50169512
59Gastrointestinal carcinoma (HP:0002672)2.50169512
60Absent forearm bone (HP:0003953)2.48025499
61Aplasia involving forearm bones (HP:0009822)2.48025499
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.47792724
63Duplication of thumb phalanx (HP:0009942)2.46742960
64Rhabdomyosarcoma (HP:0002859)2.44430754
65Medulloblastoma (HP:0002885)2.43609848
66Renal agenesis (HP:0000104)2.38029886
67Hepatoblastoma (HP:0002884)2.32823781
68Abnormality of pyrimidine metabolism (HP:0004353)2.32393699
69Abnormality of chromosome stability (HP:0003220)2.31841063
70Pili torti (HP:0003777)2.29678024
71Shawl scrotum (HP:0000049)2.29445589
72Missing ribs (HP:0000921)2.28488314
73Abnormality of the distal phalanx of the thumb (HP:0009617)2.28311440
74Alopecia of scalp (HP:0002293)2.28213733
75Abnormality of the carotid arteries (HP:0005344)2.27592867
76Rectal prolapse (HP:0002035)2.26370912
77Optic nerve coloboma (HP:0000588)2.25605030
78Aplasia/Hypoplasia of the ulna (HP:0006495)2.25520321
79Deviation of the thumb (HP:0009603)2.24899115
80Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.24825480
81Abnormality of the duodenum (HP:0002246)2.24269568
82Renal hypoplasia (HP:0000089)2.23200628
83Neoplasm of striated muscle (HP:0009728)2.19885152
84Malnutrition (HP:0004395)2.19057126
85Abnormal biliary tract morphology (HP:0012440)2.18135772
86Pseudobulbar signs (HP:0002200)2.17865180
87Atrophic scars (HP:0001075)2.17475112
88Vertebral hypoplasia (HP:0008417)2.16751419
89Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.16751419
90Protrusio acetabuli (HP:0003179)2.14445679
91Chromsome breakage (HP:0040012)2.12857231
92Milia (HP:0001056)2.11341015
93Abnormality of the preputium (HP:0100587)2.11009438
94Breast hypoplasia (HP:0003187)2.10488692
95Abnormal pancreas size (HP:0012094)2.09153761
96Colon cancer (HP:0003003)2.08044240
97Proximal placement of thumb (HP:0009623)2.07938231
98Abnormality of the middle phalanges of the toes (HP:0010183)2.06472118
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04800395
100Carpal synostosis (HP:0009702)2.03944666
101Agnosia (HP:0010524)2.02115955
102Fused cervical vertebrae (HP:0002949)1.99615716
103Cerebral aneurysm (HP:0004944)1.99317719
104Progressive inability to walk (HP:0002505)1.98788940
105Bowed forearm bones (HP:0003956)1.98447996
106Bowing of the arm (HP:0006488)1.98447996
107Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.97355028
108Short 1st metacarpal (HP:0010034)1.97355028
109Chin dimple (HP:0010751)1.95173140
110Abnormality of the 1st metacarpal (HP:0010009)1.95060285
111Hypolipoproteinemia (HP:0010981)1.94337438
112Ureteral duplication (HP:0000073)1.94149640
113Uterine neoplasm (HP:0010784)1.94118199
114Abnormality of the proximal phalanges of the hand (HP:0009834)1.93986824
115Short phalanx of the thumb (HP:0009660)1.93399226
116Uterine leiomyosarcoma (HP:0002891)1.92584593
117Leiomyosarcoma (HP:0100243)1.92584593
118Mixed hearing impairment (HP:0000410)1.91861145
119Small intestinal stenosis (HP:0012848)1.90547311
120Duodenal stenosis (HP:0100867)1.90547311
121Abdominal situs inversus (HP:0003363)1.87263653
122Abnormality of abdominal situs (HP:0011620)1.87263653
123Abnormal vertebral ossification (HP:0100569)1.86012878
124Ankle contracture (HP:0006466)1.85778260
125Woolly hair (HP:0002224)1.85497600
126Vertebral fusion (HP:0002948)1.85205556
127Spastic diplegia (HP:0001264)1.84957362
128Urethral obstruction (HP:0000796)1.84028012
129Oligodactyly (HP:0012165)1.80574262
130Choanal atresia (HP:0000453)1.79647989
131Impulsivity (HP:0100710)1.79259039
132Tibial bowing (HP:0002982)1.79127228
133Transitional cell carcinoma of the bladder (HP:0006740)1.77962762
134Labial hypoplasia (HP:0000066)1.77120626
135Pigmentary retinal degeneration (HP:0001146)1.76849304
136Hypoplastic labia majora (HP:0000059)1.76112663
137Genu recurvatum (HP:0002816)1.75957427
138Facial asymmetry (HP:0000324)1.75877296
139Chorioretinal atrophy (HP:0000533)1.75456369
140Gastrointestinal atresia (HP:0002589)1.75137633
141Large earlobe (HP:0009748)1.74487204
142Shallow orbits (HP:0000586)1.74248887
143Basal cell carcinoma (HP:0002671)1.73862330
144Anal atresia (HP:0002023)1.72925842
145Radial bowing (HP:0002986)1.72154484
146Abnormality of cochlea (HP:0000375)1.71437314
147Supernumerary ribs (HP:0005815)1.71375877
148Heterotopia (HP:0002282)1.71242300
149Esophageal varix (HP:0002040)1.71054354
150Abnormality of the nasal septum (HP:0000419)1.70814667
151Preaxial hand polydactyly (HP:0001177)1.70496389
152Trismus (HP:0000211)1.70344784
153Hypoplastic female external genitalia (HP:0012815)1.69136901
154Premature rupture of membranes (HP:0001788)1.65789348
155Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.64713013
156Hemivertebrae (HP:0002937)1.64386037
157Abnormality of glutamine family amino acid metabolism (HP:0010902)1.63904727
158Skull defect (HP:0001362)1.63631597
159Anal stenosis (HP:0002025)1.63617638
160Abnormal number of incisors (HP:0011064)1.63069580
161Intestinal fistula (HP:0100819)1.62551524
162Abnormality of monocarboxylic acid metabolism (HP:0010996)1.61923226
163Hypochromic microcytic anemia (HP:0004840)1.60160834
164Ovarian neoplasm (HP:0100615)1.59794795
165Pendular nystagmus (HP:0012043)1.58719614
166Increased connective tissue (HP:0009025)1.57522363
167Aneurysm (HP:0002617)1.57314489
168Delayed puberty (HP:0000823)1.57163964
169Abnormality of the calcaneus (HP:0008364)1.56315552
170Hand muscle atrophy (HP:0009130)1.55773467
171Abnormality of the labia majora (HP:0012881)1.55378283
172Widely patent fontanelles and sutures (HP:0004492)1.54705682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.09281192
2CDK124.98264321
3PDK24.26218972
4LATS13.10855359
5TRIM282.78562851
6GRK12.70705778
7AKT32.68029450
8MKNK22.52474281
9BRSK22.34043849
10MKNK12.32863403
11TTK2.06251674
12WNK32.04842642
13CDK191.96815034
14LMTK21.96348336
15RPS6KB21.95887752
16BMPR1B1.93240225
17DDR21.90277192
18CDC71.89294855
19STK161.88428416
20MET1.87837653
21TNIK1.86794015
22STK101.85880386
23ICK1.83531474
24PKN21.81401198
25MST41.81045298
26MAP3K101.68393912
27FRK1.65031515
28RIPK11.64864548
29CDK71.59968548
30PLK41.57760473
31BMX1.56220523
32NEK21.54267175
33SRPK11.42704088
34STK31.41945563
35CDK61.39980525
36PAK41.39407709
37EPHA41.39223615
38NLK1.35073716
39BRD41.33817566
40ERBB41.32772719
41NEK11.30473157
42MTOR1.28234684
43CHEK21.27846764
44PDGFRA1.26457801
45MAP3K81.24268874
46FLT31.23316584
47PLK21.22597234
48WEE11.20113150
49TAF11.15933618
50AURKB1.12974267
51STK38L1.11216829
52SIK11.10178085
53EEF2K1.07779809
54STK41.07314034
55LATS21.06410409
56ERN11.01480212
57CDK41.00673400
58PLK10.99787038
59ALK0.98595531
60PTK60.98371647
61PIM10.96935646
62GRK60.96003073
63PRKG20.95860049
64CHEK10.95853370
65ZAK0.93298807
66EPHB20.93179612
67MAP2K20.91692334
68MELK0.90290014
69PTK20.88646399
70BCR0.87832710
71SCYL20.87104143
72VRK10.83963641
73TYRO30.83483297
74VRK20.82853817
75DYRK1B0.82320635
76ATR0.81954293
77BRSK10.81950571
78PAK20.81703874
79PIK3CA0.81601764
80FGFR10.81347665
81GSK3A0.80916654
82CASK0.80132577
83TTN0.80121687
84PRKCI0.80106686
85FER0.78688109
86CAMK1G0.78058415
87MAP3K40.78008260
88FGR0.77915381
89TLK10.74707978
90MST1R0.73557575
91TGFBR10.72209747
92PASK0.71639725
93ATM0.71478906
94EPHB10.68846488
95CDK20.68086698
96MAP2K10.67437249
97CHUK0.67148126
98MAP3K30.64447886
99CSNK1G10.62744573
100PDGFRB0.62151808
101CSNK1D0.61486726
102AKT20.61092709
103CAMK1D0.60428427
104CSNK1A10.60304954
105ACVR1B0.60176315
106TSSK60.57875964
107MATK0.57719491
108FGFR20.54834571
109PRKDC0.54577825
110LRRK20.52977663
111CSK0.52520045
112PLK30.52243696
113DYRK30.52049196
114TESK20.51174873
115ERBB20.49274167
116MAPK10.49201644
117CDK90.48411528
118PNCK0.48197417
119CSNK2A10.47407897
120SGK4940.46177375
121SGK2230.46177375
122NUAK10.45933391
123EIF2AK30.44957509
124MAP3K20.44815950
125EPHA30.43918677
126CSNK1E0.42575714
127RPS6KA40.42381166
128CDK10.42167457
129CLK10.41391611
130BRAF0.41066250
131BUB10.40027808
132DYRK20.39428922
133EIF2AK20.38906941
134MAP3K110.38857535
135MAP2K70.38450041
136AURKA0.38018950
137PAK10.37404305
138MAPK140.37068753
139SGK20.36924507
140PBK0.35578680
141MAPK110.35489441
142INSR0.34923068
143INSRR0.33131294
144GSK3B0.32891958
145OXSR10.32590856
146FGFR40.30428456
147MAP3K90.29959133
148CSNK1A1L0.29726632
149PRKCG0.28369950
150SGK30.27993476
151PRKCE0.27077469

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.39839428
2One carbon pool by folate_Homo sapiens_hsa006702.39315307
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33895042
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.24387827
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13625734
6Fat digestion and absorption_Homo sapiens_hsa049752.11546325
7Adherens junction_Homo sapiens_hsa045202.01435705
8Renin-angiotensin system_Homo sapiens_hsa046141.99916243
9Mineral absorption_Homo sapiens_hsa049781.94308264
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93955092
11Systemic lupus erythematosus_Homo sapiens_hsa053221.87012644
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86354730
13RNA transport_Homo sapiens_hsa030131.81681100
14Pyruvate metabolism_Homo sapiens_hsa006201.79823048
15DNA replication_Homo sapiens_hsa030301.72228229
16Nitrogen metabolism_Homo sapiens_hsa009101.70571844
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.70541754
18Bladder cancer_Homo sapiens_hsa052191.69517385
19p53 signaling pathway_Homo sapiens_hsa041151.66930218
20* Hippo signaling pathway_Homo sapiens_hsa043901.64123550
21Cell cycle_Homo sapiens_hsa041101.59902232
22* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59868364
23MicroRNAs in cancer_Homo sapiens_hsa052061.57021261
24Folate biosynthesis_Homo sapiens_hsa007901.55149069
25Steroid biosynthesis_Homo sapiens_hsa001001.54365821
26Propanoate metabolism_Homo sapiens_hsa006401.50769731
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47277743
28Lysine degradation_Homo sapiens_hsa003101.47122099
29Vitamin digestion and absorption_Homo sapiens_hsa049771.46589742
30Retinol metabolism_Homo sapiens_hsa008301.45157524
31Tight junction_Homo sapiens_hsa045301.42654754
32Small cell lung cancer_Homo sapiens_hsa052221.37863995
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37619847
34Fructose and mannose metabolism_Homo sapiens_hsa000511.37297890
35TGF-beta signaling pathway_Homo sapiens_hsa043501.35640415
36Viral carcinogenesis_Homo sapiens_hsa052031.33215315
37ECM-receptor interaction_Homo sapiens_hsa045121.29462202
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27586992
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27255693
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26893795
41Protein digestion and absorption_Homo sapiens_hsa049741.26040528
42Selenocompound metabolism_Homo sapiens_hsa004501.25356527
43Fatty acid degradation_Homo sapiens_hsa000711.24111410
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23883485
45Galactose metabolism_Homo sapiens_hsa000521.23764778
46Spliceosome_Homo sapiens_hsa030401.23239414
47Base excision repair_Homo sapiens_hsa034101.21487587
48mRNA surveillance pathway_Homo sapiens_hsa030151.21395241
49Caffeine metabolism_Homo sapiens_hsa002321.20575728
50* Basal cell carcinoma_Homo sapiens_hsa052171.20042007
51Notch signaling pathway_Homo sapiens_hsa043301.18027990
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15772857
53Thyroid cancer_Homo sapiens_hsa052161.12776155
54Basal transcription factors_Homo sapiens_hsa030221.09922648
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07973712
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.06444931
57Fanconi anemia pathway_Homo sapiens_hsa034601.04427048
58Fatty acid biosynthesis_Homo sapiens_hsa000611.04162677
59Biosynthesis of amino acids_Homo sapiens_hsa012301.01904516
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00844482
61Nucleotide excision repair_Homo sapiens_hsa034200.99358129
62RNA polymerase_Homo sapiens_hsa030200.98555086
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96484104
64Homologous recombination_Homo sapiens_hsa034400.94753868
65Glutathione metabolism_Homo sapiens_hsa004800.92544815
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92239605
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91894239
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91818787
69Fatty acid metabolism_Homo sapiens_hsa012120.91115811
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.90756183
71mTOR signaling pathway_Homo sapiens_hsa041500.90726540
72Arginine and proline metabolism_Homo sapiens_hsa003300.90354885
73Hedgehog signaling pathway_Homo sapiens_hsa043400.89722353
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88940531
75beta-Alanine metabolism_Homo sapiens_hsa004100.86015718
76Focal adhesion_Homo sapiens_hsa045100.85812145
77Peroxisome_Homo sapiens_hsa041460.85724002
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84826782
79* Proteoglycans in cancer_Homo sapiens_hsa052050.84226991
80* Wnt signaling pathway_Homo sapiens_hsa043100.83794748
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83672065
82Bile secretion_Homo sapiens_hsa049760.82446586
83Starch and sucrose metabolism_Homo sapiens_hsa005000.82226138
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.81027357
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80653038
86Arginine biosynthesis_Homo sapiens_hsa002200.80651395
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79803280
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78812093
89Butanoate metabolism_Homo sapiens_hsa006500.77017582
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76580724
91Prostate cancer_Homo sapiens_hsa052150.73515860
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72796514
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.70156233
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.68846568
95Chronic myeloid leukemia_Homo sapiens_hsa052200.68468973
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66842055
97Sulfur relay system_Homo sapiens_hsa041220.66109120
98Ether lipid metabolism_Homo sapiens_hsa005650.65894154
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65333607
100* Pathways in cancer_Homo sapiens_hsa052000.65082048
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64967058
102Colorectal cancer_Homo sapiens_hsa052100.64295479
103Oocyte meiosis_Homo sapiens_hsa041140.63752398
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61773090
105Sulfur metabolism_Homo sapiens_hsa009200.61489057
106Endometrial cancer_Homo sapiens_hsa052130.61435675
107Apoptosis_Homo sapiens_hsa042100.60030837
108Glycerolipid metabolism_Homo sapiens_hsa005610.59765139
109Amoebiasis_Homo sapiens_hsa051460.59359811
110Non-homologous end-joining_Homo sapiens_hsa034500.59284270
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59006145
112Pentose phosphate pathway_Homo sapiens_hsa000300.58974977
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.58362008
114Complement and coagulation cascades_Homo sapiens_hsa046100.57917764
115Pyrimidine metabolism_Homo sapiens_hsa002400.55468484
116Melanoma_Homo sapiens_hsa052180.55193108
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54474726
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54217351
119RNA degradation_Homo sapiens_hsa030180.53446456
120* HTLV-I infection_Homo sapiens_hsa051660.52094120
121Metabolic pathways_Homo sapiens_hsa011000.51607048
122N-Glycan biosynthesis_Homo sapiens_hsa005100.51606881
123Carbon metabolism_Homo sapiens_hsa012000.51540183
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51049785
125Axon guidance_Homo sapiens_hsa043600.50190315
126Proteasome_Homo sapiens_hsa030500.50131966
127Tryptophan metabolism_Homo sapiens_hsa003800.49543346
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48837543
129Collecting duct acid secretion_Homo sapiens_hsa049660.47500367
130Herpes simplex infection_Homo sapiens_hsa051680.47011362
131Histidine metabolism_Homo sapiens_hsa003400.46146581
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44980740
133Alcoholism_Homo sapiens_hsa050340.44570274
134Legionellosis_Homo sapiens_hsa051340.43057808
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.41410375
136Chemical carcinogenesis_Homo sapiens_hsa052040.41274555
137PPAR signaling pathway_Homo sapiens_hsa033200.40576860
138Pancreatic cancer_Homo sapiens_hsa052120.39942842
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39608942
140Viral myocarditis_Homo sapiens_hsa054160.39116265
141AMPK signaling pathway_Homo sapiens_hsa041520.38907749
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38566020
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37953317

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